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KCNA1 / Kv1.1 Antibody (Aa256-305) Rabbit Polyclonal Antibody Catalog # ALS14838

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KCNA1 / Kv1.1 Antibody (Aa256-305) Rabbit Polyclonal Antibody Catalog # ALS14838 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 KCNA1 / Kv1.1 Antibody (aa256-305) Rabbit Polyclonal Antibody Catalog # ALS14838 Specification KCNA1 / Kv1.1 Antibody (aa256-305) - Product Information Application WB, IHC Primary Accession Q09470 Reactivity Human, Mouse, Rat Host Rabbit Clonality Polyclonal Calculated MW 56kDa KDa KCNA1 / Kv1.1 Antibody (aa256-305) - Additional Information Western blot of extracts from Gene ID 3736 HUVEC/MCF-7/HeLa cells, using KCNA1 Antibody. Other Names Potassium voltage-gated channel subfamily A member 1, Voltage-gated K(+) channel HuKI, Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv1.1, KCNA1 Target/Specificity KCNA1 Antibody detects endogenous levels of total KCNA1 protein. Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Anti-KCNA1 / Kv1.1 antibody IHC of human Precautions KCNA1 / Kv1.1 Antibody (aa256-305) is for brain, cerebellum, Purkinje cells. research use only and not for use in diagnostic or therapeutic procedures. KCNA1 / Kv1.1 Antibody (aa256-305) - Background KCNA1 / Kv1.1 Antibody (aa256-305) - Protein Voltage-gated potassium channel that Information mediates transmembrane potassium transport in excitable membranes, primarily in the brain Name KCNA1 and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the Function regulation of the membrane potential and Voltage-gated potassium channel that nerve signaling, and prevents neuronal mediates transmembrane potassium hyperexcitability (PubMed:17156368). Forms transport in excitable membranes, primarily tetrameric potassium- selective channels in the brain and the central nervous Page 1/5 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 system, but also in the kidney (PubMed:<a through which potassium ions pass in href="http://www.uniprot.org/citations/1990 accordance with their electrochemical 3818" target="_blank">19903818</a>). gradient. The channel alternates between Contributes to the regulation of the opened and closed conformations in response membrane potential and nerve signaling, to the voltage difference across the membrane and prevents neuronal hyperexcitability (PubMed:19912772). Can form functional (PubMed:<a href="http://www.uniprot.org/c homotetrameric channels and itations/17156368" heterotetrameric channels that contain target="_blank">17156368</a>). Forms variable proportions of KCNA1, KCNA2, KCNA4, tetrameric potassium-selective channels KCNA5, KCNA6, KCNA7, and possibly other through which potassium ions pass in family members as well; channel properties accordance with their electrochemical depend on the type of alpha subunits that are gradient. The channel alternates between part of the channel (PubMed:12077175, opened and closed conformations in PubMed:17156368). Channel properties are response to the voltage difference across the membrane (PubMed:<a href="http://ww modulated by cytoplasmic beta subunits that w.uniprot.org/citations/19912772" regulate the subcellular location of the alpha target="_blank">19912772</a>). Can form subunits and promote rapid inactivation of functional homotetrameric channels and delayed rectifier potassium channels heterotetrameric channels that contain (PubMed:12077175, PubMed:17156368). In variable proportions of KCNA1, KCNA2, vivo, membranes probably contain a mixture of KCNA4, KCNA5, KCNA6, KCNA7, and heteromeric potassium channel complexes, possibly other family members as well; making it difficult to assign currents observed channel properties depend on the type of in intact tissues to any particular potassium alpha subunits that are part of the channel channel family member. Homotetrameric (PubMed:<a href="http://www.uniprot.org/c KCNA1 forms a delayed-rectifier potassium itations/12077175" channel that opens in response to membrane target="_blank">12077175</a>, depolarization, followed by slow spontaneous PubMed:<a href="http://www.uniprot.org/ci channel closure (PubMed:19912772, tations/17156368" PubMed:19968958, PubMed:19307729, target="_blank">17156368</a>). Channel PubMed:19903818). In contrast, a properties are modulated by cytoplasmic heterotetrameric channel formed by KCNA1 beta subunits that regulate the subcellular and KCNA4 shows rapid inactivation location of the alpha subunits and promote (PubMed:17156368). Regulates neuronal rapid inactivation of delayed rectifier excitability in hippocampus, especially in potassium channels (PubMed:<a href="http mossy fibers and medial perforant path axons, ://www.uniprot.org/citations/12077175" preventing neuronal hyperexcitability. target="_blank">12077175</a>, Response to toxins that are selective for PubMed:<a href="http://www.uniprot.org/ci KCNA1, respectively for KCNA2, suggests that tations/17156368" target="_blank">17156368</a>). In vivo, heteromeric potassium channels composed of membranes probably contain a mixture of both KCNA1 and KCNA2 play a role in heteromeric potassium channel complexes, pacemaking and regulate the output of deep making it difficult to assign currents cerebellar nuclear neurons (By similarity). May observed in intact tissues to any particular function as down- stream effector for G potassium channel family member. protein-coupled receptors and inhibit Homotetrameric KCNA1 forms a GABAergic inputs to basolateral amygdala delayed-rectifier potassium channel that neurons (By similarity). May contribute to the opens in response to membrane regulation of neurotransmitter release, such as depolarization, followed by slow gamma-aminobutyric acid (GABA) release (By spontaneous channel closure (PubMed:<a h similarity). Plays a role in regulating the ref="http://www.uniprot.org/citations/19912 generation of action potentials and preventing 772" target="_blank">19912772</a>, hyperexcitability in myelinated axons of the PubMed:<a href="http://www.uniprot.org/ci vagus nerve, and thereby contributes to the tations/19968958" regulation of heart contraction (By similarity). target="_blank">19968958</a>, Required for normal neuromuscular responses PubMed:<a href="http://www.uniprot.org/ci (PubMed:11026449, PubMed:17136396). Page 2/5 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 tations/19307729" Regulates the frequency of neuronal action target="_blank">19307729</a>, potential firing in response to mechanical PubMed:<a href="http://www.uniprot.org/ci stimuli, and plays a role in the perception of tations/19903818" pain caused by mechanical stimuli, but does target="_blank">19903818</a>). In not play a role in the perception of pain due to contrast, a heterotetrameric channel heat stimuli (By similarity). Required for formed by KCNA1 and KCNA4 shows rapid normal responses to auditory stimuli and inactivation (PubMed:<a href="http://www. precise location of sound sources, but not for uniprot.org/citations/17156368" sound perception (By similarity). The use of target="_blank">17156368</a>). toxins that block specific channels suggest that Regulates neuronal excitability in it contributes to the regulation of the axonal hippocampus, especially in mossy fibers release of the neurotransmitter dopamine (By and medial perforant path axons, similarity). Required for normal postnatal brain preventing neuronal hyperexcitability. development and normal proliferation of Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests neuronal precursor cells in the brain (By that heteromeric potassium channels similarity). Plays a role in the reabsorption of composed of both KCNA1 and KCNA2 play a Mg(2+) in the distal convoluted tubules in the role in pacemaking and regulate the output kidney and in magnesium ion homeostasis, of deep cerebellar nuclear neurons (By probably via its effect on the membrane similarity). May function as down-stream potential (PubMed:23903368, effector for G protein-coupled receptors and PubMed:19307729). inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May KCNA1 / Kv1.1 Antibody (aa256-305) - contribute to the regulation of References neurotransmitter release, such as gamma-aminobutyric acid (GABA) release Ramaswami M.,et al.Mol. Cell. Neurosci. (By similarity). Plays a role in regulating the 1:214-223(1990). generation of action potentials and Scherer S.E.,et al.Nature 440:346-351(2006). preventing hyperexcitability in myelinated Mural R.J.,et al.Submitted (SEP-2005) to the axons of the vagus nerve, and thereby EMBL/GenBank/DDBJ databases. contributes to the regulation of heart Freeman S.N.,et al.Biochem. Soc. Trans. contraction (By similarity). Required for 18:891-892(1990). normal neuromuscular responses Rasband M.N.,et al.J. Comp. Neurol. (PubMed:<a href="http://www.uniprot.org/c 429:166-176(2001). itations/11026449" target="_blank">11026449</a>, PubMed:<a href="http://www.uniprot.org/ci tations/17136396" target="_blank">17136396</a>). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal
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