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Book of Abstracts 11rH CONGRESS OF THE INTERNATIONAL SOCIETY FOR AUTONOMIC NEUROSCIENCE BOOK OF JULY 25 - 27, 2019 I LOS ANGELES, CALIFORNIA ABSTRACTS Confocal microscopic image of a mouse dorsal root ganglion labeled with a multicolor adeno-associated virus-based approach. Neurons within the dorsal root ganglia are critical for processing sensory information from visceral organs. Image courtesy of Pradeep Rajendran and Rosemary Challis of the Shivkumar Lab at UCLA and the Gradinaru Lab at Caltech. isan2019.org 11rH CONGRESS OF THE INTERNATIONAL SOC IETY FOR AUTONOMIC NEUROSCIENCE JULY 25 - 27 , 2019 LOS ANGELES , CALIFORNIA TABLE OF CONTENTS ORAL PRESENTATIONS 4 POSTER PRESENTATIONS THURSDAY JULY 25 60 FRIDAY JULY 26 82 SATURDAY JULY 27 112 TECHNOLOGY SHOWCASE 142 AUTHOR INDEX 154 11TH CONGRESS OF THE INTERNATIONAL SOCIETY FOR AUTONOMIC NEUROSCIENCE JULY 25-27, 2019 | LOS ANGELES CALIFORNIA 2 ORAL PRESENTATIONS isan2019.org ORAL PRESENTATIONS SESSION: ENTERIC NEURAL CIRCUITRY IN MOUSE AND HUMAN COLON: THE CHANGING FACE OF MORPHOLOGY, FUNCTION AND THERAPEUTIC LEADS JULY 25, 2019 | 9:20 AM–11:20 AM ISAN19.003 ISAN19.005 REFINING ENTERIC NEURAL CIRCUITRY BY VISUALIZING THE HUMAN ENTERIC NERVOUS SYSTEM QUANTITATIVE MORPHOLOGY, TRANSCRIPTOMICS IN 3-DIMENSIONS: NEW WAYS TO THINK ABOUT AND FUNCTION IN MICE AUTONOMIC NEUROPATHY Marthe Howard, Andrea L. Kalinoski, Joseph F. Margiotta, Kahleb Graham1, Silvia Huerta Lopez1, Rajarshi Sengupta1, Samantha Mckee, Kalina Venkova, Alexander Hristov Archana Shenoy1, Christina M. Wright1, Sabine Schneider1, Michael D. Feldman2, Emma E. Furth3, Federico University of Toledo Health Sciences, Neurosciences, Toledo, 2 4 1 UNITED STATES OF AMERICA Valdivieso , Amanda Lemke , Benjamin J. Wilkins , Marthe Howard5, Pierre A. Russo6, Edward J. Doolin1, Robert Heuckeroth7 Abstract: The enteric nervous system (ENS) is comprised 1The Children’s Hospital of Philadelphia and The Perelman School of a network of ganglia located within the wall of the of Medicine at the University of Pennsylvania, Philadelphia, UNITED 2 gastrointestinal (GI) tract that control peristalsis, secretion, STATES OF AMERICA, The Perelman School of Medicine at the blood flow, nutrient transport and immune function. University of Pennsylvania, Pathology and Laboratory Medicine, Philadelphia, UNITED STATES OF AMERICA, 3The Perelman School Studies conducted primarily in Guinea pig small intestine of Medicine at the University of Pennsylvania, Philadelphia, UNITED have provided significant information on the function and STATES OF AMERICA, 4The Children’s Hospital of Philadelphia, architecture of enteric neural circuitry including neurochemical Pediatrics, Philadelphia, UNITED STATES OF AMERICA, 5University coding, electrophysiology and integrated function. However, of Toledo College of Medicine, Neurosciences, Toledo, UNITED recent evidence suggests significant differences between the STATES OF AMERICA, 6The Children’s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, small intestine and colon as well as between species. With 7 the advent of molecular genetics, use of mouse models to Pathology, Philadelphia, UNITED STATES OF AMERICA, The Children’s Hospital of Philadelphia and The Perelman School of investigate ENS function and architecture has gained much Medicine at the University of Pennsylvania, Pediatrics, Philadelphia, interest. Using confocal imaging and 3D reconstruction we UNITED STATES OF AMERICA have mapped in detail the mouse colon. We show that there are significant differences in neuron number, neurochemical coding and neural network architecture between the Abstract: Background: Bowel motility disorders are common proximal and distal colon. We have identified several and debilitating, but remain poorly understood. One major “new” neuronal types based on neurochemical code, when problem is that many cell types work together to control compared to the Guinea pig, and have identified functional bowel motility, but these cells are buried in the bowel wall and classes of neurotransmitter receptors previously thought difficult to see without sectioning. Once sectioning is done, not to function in the ENS. Based on 3D reconstruction three dimensional structures that control motility are almost and GCaMP imaging we have demonstrated both intra and impossible to understand. Objective: To develop highly interganglionic synaptic connectivity. Based on RNA-Seq reproducible methods to visualize enteric neurons, glia, and from wildtype colonic ganglia and compared to FACSorted other cells that control bowel motility in human colon, without cell type-specific neurons, we have determined patterns of sectioning. Method: We established a robust pipeline to make expression of neurotransmitter receptors, genes associated the colon transparent, stain with antibodies, and visualize with neurotransmission, neuromodulators and immune many cell types that control bowel motility by confocal markers for various GI disorders. The overarching goal of imaging. We pursued detailed anatomic analysis of enteric our studies is to generate a predictive neural circuit map of nervous system structure to define “normal” in adult human the mouse colon. colon. Results: We generated hundreds of three dimensional images that provide unprecedented views of human colon Disclosure: No significant relationships. enteric nervous system (ENS). Quantitative analyses provide a new “gold standard” for normal ENS structure. We validated 16 antibodies that work well with our method. Discussion: Even after decades of studying the ENS, we were stunned by the new images generated. Disclosure: No significant relationships. 11TH CONGRESS OF THE INTERNATIONAL SOCIETY FOR AUTONOMIC NEUROSCIENCE JULY 25-27, 2019 | LOS ANGELES CALIFORNIA 4 ORAL PRESENTATIONS SESSION: AUTONOMIC CONTROL OF INFLAMMATION - NEW INSIGHTS INTO PATHWAYS AND MECHANISMS JULY 25, 2019 | 9:20 AM–11:20 AM ISAN19.012 THE SPLANCHNIC ANTI-INFLAMMATORY PATHWAY: MAPPING ITS PERIPHERAL AND CENTRAL BRANCHES Davide Martelli1, David G.S. Farmer2, Michael J. Mckinley3, Robin M. Mcallen4 1Università di Bologna, Department of Biomedical and Neuromotor Sciences, Bologna, ITALY, 2Florey Institute of Neuroscience and Mental Health, Parkville, VIC, AUSTRALIA, 3Florey Institute of Neuroscience and Mental Health, Parkville VIC, AUSTRALIA, 4Florey Institute of Neuroscience and Mental Health, Parkville, VIC, AUSTRALIA Abstract: The nervous and immune systems are both critical for life and health, and naturally, they affect one another. The brain exerts control over the amount of inflammation induced by an immune challenge in two main ways: 1) activating the hypothalamic-pituitary-adrenal axis to release glucocorticoids, which suppress inflammation; 2) via a mechanism that has been termed the inflammatory reflex. The inflammatory reflex is a classic neural reflex that is activated in response to a systemic immune challenge and its function is to dampen down the ensuing inflammation. Its efferent motor pathway, termed the splanchnic anti-inflammatory pathway (SAIP), travels in the splanchnic sympathetic nerves. The SAIP is endogenously activated by immune challenge, but can also be engaged exogenously by electrical stimulation of vagal afferent nerve fibers - a promising strategy for treating inflammatory conditions. While much background evidence implicates the spleen as the principal target organ where sympathetic nerves inhibit immune function, we recently showed in rats that the SAIP functions effectively in splenectomized animals. We found that the anti-inflammatory influence of the SAIP is distributed among several, if not all, organs and tissues within the abdomen. We are now investigating which pre-motor sympathetic pathways in the CNS drive the SAIP. Our preliminary results indicate that the key premotor neurons may not be in the hypothalamus, as initially hypothesized, but in the brainstem. Disclosure: No significant relationships. 11TH CONGRESS OF THE INTERNATIONAL SOCIETY FOR AUTONOMIC NEUROSCIENCE JULY 25-27, 2019 | LOS ANGELES CALIFORNIA 5 ORAL PRESENTATIONS SESSION: SYMPOSIA-RELATED ORAL PRESENTATIONS: ENTERIC NEURAL CIRCUITRY IN MOUSE AND HUMAN COLON: THE CHANGING FACE OF MORPHOLOGY, FUNCTION AND THERAPEUTIC LEADS JULY 25, 2019 | 11:20 AM–11:40 AM ISAN19.019 ISAN19.020 NICOTINIC ACETYLCHOLINE RECEPTORS MEDIATE IDENTIFICATION OF NOVEL MARKERS FOR ENTERIC AND MODULATE CHOLINERGIC CIRCUIT ACTIVITY IN NEURONS IN HEALTHY HUMAN ADULTS USING RNA- MOUSE MYENTERIC GANGLIA SEQUENCING Joseph Margiotta, Andrea L. Kalinoski, Marthe Howard Aaron May-Zhang, E. Michelle Southard-Smith, Karen K. Deal University of Toledo College of Medicine, Neurosciences, Toledo, UNITED STATES OF AMERICA Vanderbilt University Medical Center, Nashville, UNITED STATES OF AMERICA Abstract: Cholinergic nicotinic acetylcholine receptors (nAChRs) mediate the bulk of transmission in myenteric Abstract: The enteric nervous system (ENS) or “second ganglia, making them critical components of enteric circuitry brain” is the network of neurons and glia in the intestinal producing rhythmic, reciprocal activation of intestinal wall that coordinates the essential functions of the bowel. To longitudinal and circular muscles. To probe cholinergic expand our limited understanding of neuronal diversity within myenteric circuits in-situ, colon strips from mice engineered the human ENS, we generated a transcriptome catalog of all to express GCaMP6f in cholinergic neurons were challenged genes enriched in enteric ganglia from the duodenum,
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