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Immune Function FEATURE ARTICLES 7 Personal Approach to Healthy Immunity 28 Lactoferrin Defends against Viruses ;@ ))1*!Ļ*$*%*#ƈ!0/+"!(0+*%* 48 Boost Cellular Super Oxide Dismutase LifeExtension.com June 2020 68 Collagen-Forming Topical Peptides 77 Curb Artery-Blocking Adhesion Factors Natural Methods to Enhance IMMUNE FUNCTION PLUS: Magnesium Regenerates Synaptic Brain Connections LEMJUN20pCVR.indd 1 4/14/20 7:26 AM Humans don’t manufacture vitamin C internally, so it must be obtained through dietary sources or supplements. Vitamin C is water soluble and needs to be constantly replenished.* A highly-absorbable form of quercetin complements vitamin C’s activity in the body. Each tablet provides , mg of vitamin C and mg of Bio-Quercetin Phytosome. Item # • vegetarian tablets bottle $. * * Limited Supplies Available. One bottle will be initially shipped with the balance to follow upon our re-supply. For full product description and to order Vitamin C and Bio-Quercetin Phytosome, call --- or visit www.LifeExtension.com * PLoS Med. Sep;():e;author reply e. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. LEMJUN20pIFC.indd 1 4/14/20 11:57 AM CONTENTS LifeExtension.com June 2020 REPORTS 26 ON THE COVER NATURAL METHODS TO ENHANCE IMMUNE FUNCTION Immune senescence underlies many diseases of aging. Life Extension® has worked with 28 38 48 58 68 77 scientists for decades seeking to restore youthful immune function. 28 LACTOFERRIN HELPS PROTECT AGAINST VIRUSES Lactoferrin, a protein found in mother’s milk, shows antiviral activity in preclinical trials. It impedes viral binding to cell membranes, while activating immune defenses. 38 IMMUNE-BOOSTING EFFECTS OF MELATONIN As melatonin levels diminish with age, immune function declines. Boosting melatonin levels can help rejuvenate immune function. 48 BOOST INTERNAL ANTIOXIDANT DEFENSES Oxidative stress damages cells and accelerates certain aging processes. Two botanicals increase cellular levels of superoxide dismutase (SOD) to boost the body’s internal oxidant defense system. 58 MAGNESIUM RESTORES SYNAPTIC BRAIN STRUCTURES A patented, bioavailable form of magnesium, developed by scientists at MIT, increases synaptic plasticity and reduces brain aging by 9 years. 68 TOTAL COLLAGEN CARE RESTORES YOUTHFUL SKIN A topical formula with a trio of peptides has been shown to synthesize all major collagen types to revitalize aging skin. 77 FISH OIL REDUCES ARTERIAL ADHESION MOLECULES 26 Adhesion molecules are a contributing factor to atherosclerosis and heart disease. Fish oil can reduce adhesion molecules by up to 28%. DEPARTMENTS 7 AS WE SEE IT: 19 IN THE NEWS A PERSONAL APPROACH Vitamin D improves cancer survival TO HEALTHIER IMMUNITY rate; lactoferrin fights infectious dis- In this editorial, Bill Faloon eases; quercetin lowers blood pressure; describes his personal anti- metformin reduces acne in women; viral protocol that has apparently optimism reduces cardiovascular risk. 19 worked for the past 37 years. 83 ASK THE DOCTOR Drs. Albani and Fogle discuss two new, innovative tests that provide insight into your microbiome and toxic chemical levels. 7 83 JUNE 2020 | LIFE EXTENSION | 1 LEMJUN20p.indd 1 4/14/20 12:07 PM Volume 26 • Number Six LifeExtension.com June 2020 Publisher • LE Publications, Inc. Editorial Editor-in-Chief • Philip Smith Executive Managing Editor • Renee Price Medical Editor • Hernando Latorre, MD, MSc Senior Editor • Dan Jewel Senior Staff Writer • Michael Downey Department Editor • Laurie Mathena Associate Editor • Rivka Rosenberger, EdD Creative Director • Robert Vergara Facebook.com/LifeExtension Twitter.com/LifeExtension Art Director • Alexandra Maldonado For instant access to special For up-to-the-minute health offers and promotions, product tips, breaking industry news, Chief Medical Officer Chief Scientific Officer news, and exclusive health and the latest updates in Steven Joyal, MD Andrew Swick, MS, PhD and wellness information. medical research. Scientific Advisory Board Örn Adalsteinsson, PhD • Richard Black, DO • John Boik, PhD These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Aubrey de Grey, PhD • Deborah F. Harding, MD • Steven B. 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US $60 in other countries. Mail subscriptions or address changes to: LE Publications, Inc., P.O. Box 407198, Fort Lauderdale, FL 33340-7198, USA. Or phone us toll-free at: 1-800-841-5433. Canada Subscriptions: Publications mail agreement num- ber 40028967. Return undeliverable Canadian addresses to PO Box 503, RPO West Beaver Creek, Richmond Hill, ON L4B4R6. You will be sent your first issue within six weeks after LE Publications, Inc. receives your subscription fee. Periodicals Postage paid at Fort Lauderdale, FL and at additional mailing offices. POSTMASTER: Send address changes to Life Extension, P.O. Box 407198, Ft. Lauderdale, Florida 33340-7198, USA. Printed in USA. The articles in this magazine are intended for informational purposes only. They are not intended to replace the attention or advice of a physi- cian or other health-care professional. Anyone who wishes to embark on any dietary, drug, exercise, or other lifestyle change intended to prevent or treat a specific disease or condition should first consult with and seek clearance from a qualified health-care professional. LEGAL NOTICE: Health claims contained in articles and advertisements in this publication have not been approved by the FDA with the exception of FDA-approved, qualified health claims for calcium, antioxidant vitamins, folic acid and EPA and DHA omega-3 fatty acids, and selenium as noted where applicable. Life Extension ® Magazine does not endorse any of the businesses or the products and/or services that may appear in advertisements for non-Life Extension branded products or services contained in it, except to state that they are advertisers who may have paid Life Extension for placement of an advertisement in this publication. Life Extension disclaims any and all responsibilities or warranties as to the accuracy of information contained in advertisements for non-Life Extension branded products or services. For Canadian customers send change of address information and blocks of undeliverable copies to P.O. Box 1051, Fort Erie, ON L2A 6C7. 2 | LIFE EXTENSION | JUNE 2020 LEMJUN20p.indd 2 4/10/20 2:48 PM EFEND YOUR HEALTH Item # • , IU • softgels bottle $. VITAMIN D3 bottles $. each Systemic support for For full product description youthful cell function, bone and to order Vitamin D, health, and normal insulin and call --- or visit www.LifeExtension.com blood-sugar levels. CAUTION: Individuals consuming more than mcg ( IU)/day of vitamin D (from diet and supplements) should periodically obtain a serum -hydroxy vitamin D measurement. Do not exceed IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with high blood calcium levels. 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