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FEATURE ARTICLES 7 COVID-19: What to Ask Your Doctor :@ *0%Ļ#%*#ƈ!0/+"%0$%1) ;> $!* ))1*!1*0%+*ŭ((/+ƈ(%ƈŭ 48 Impact of DHEA on Longevity 58 Combat Immune Senescence LifeExtension.com July 2020 71 Leukemia Patient Case Report 78 Stress Can Increase Infection Risk The Science of Youthful Immune Function PLUS: Many COVID-19 Tests Yield Misleading Results LEMJUL20pCVR.indd 1 5/13/20 9:52 AM BROAD-SPECTRUM IMMUNE SUPPORT Lactoferrin is HJVTWVULU[VMwhey protein ILZ[RUV^UMVYP[Zimmune benefits. (UHYYH`VMW\ISPZOLKZ[\KPLZKLZJYPILZ OV^lactoferrin\WYLN\SH[LZPUUH[L HUKHKHW[P]LimmuneYLZWVUZLZ[VH ]HYPL[`VMHU[PNLUZ For full product description and to order Item #01681TNJHWZ\SLZ Lactoferrin Caps, call 1-800-544-4440 IV[[SL$45 IV[[SLZ$40 each or visit www.LifeExtension.com (Two-Month Supply) These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. LEMJUL20pIFC.indd 1 5/18/20 1:30 PM CONTENTS LifeExtension.com July 2020 REPORTS 7 ON THE COVER WHAT DOCTORS MAY CONSIDER IF COVID-19 SYMPTOMS WORSEN There are currently available therapies to discuss with physicians that may reduce the risk of a SARS-CoV-2 patient requiring ventilator support. 28 36 48 58 71 78 We also discuss COVID-19 tests 28 LITHIUM: CRITICAL FOR OVERALL HEALTH that are not the panacea portrayed By inhibiting the enzyme GSK-3, lithium can promote longevity, slow by the media and government. brain aging, and improve health parameters. 36 WHEN IMMUNE FUNCTION “FALLS OFF A CLIFF” Standardized botanicals have been shown to improve protective immune factors while reducing pro-inflammatory cytokines such as interleukin-6 (IL-6). 48 DHEA PROMOTES QUALITY OF LIFE Low levels of the hormone DHEA are associated with systemic aging and mortality. DHEA replacement can improve quality of life and reduce degenerative risks. 58 NATURAL APPROACHES TO IMPROVE IMMUNE FUNCTION Three plant-based compounds can improve immune function by several complementary mechanisms to combat immune senescence. 71 CASE REPORT: LEUKEMIA PATIENT ACHIEVES COMPLETE REMISSION Personalized precision immunotherapy results in complete remission in a terminal leukemia patient. 78 REDUCE THE ADVERSE EFFECTS OF STRESS 7 Ongoing stress triggers high levels of cortisol, which can weaken immune function. DEPARTMENTS 19 IN THE NEWS 89 SUPER FOODS Blood pressure meds best taken at Technically a fruit, pecans are rich in night; extra virgin olive oil benefits protein and healthy fats, including the brain; lactoferrin may combat oleic acid. Human and lab studies cancer; obesity-related cancers seen show they can reduce LDL and total at younger ages; even light exercise cholesterol and may cut the risk of boosts longevity. breast cancer. 19 89 JULY 2020 | LIFE EXTENSION | 1 LEMJUL20p.indd 1 5/18/20 2:12 PM Volume 26 • Number Seven LifeExtension.com July 2020 Publisher • LE Publications, Inc. Editorial Editor-in-Chief • Philip Smith Executive Managing Editor • Renee Price Medical Editor • Hernando Latorre, MD, MSc Senior Editor • Dan Jewel Senior Staff Writer • Michael Downey Department Editor • Laurie Mathena Associate Editor • Rivka Rosenberger, EdD Creative Director • Robert Vergara Facebook.com/LifeExtension Twitter.com/LifeExtension Art Director • Alexandra Maldonado For instant access to special For up-to-the-minute health offers and promotions, product tips, breaking industry news, Chief Medical Officer Chief Scientific Officer news, and exclusive health and the latest updates in Steven Joyal, MD Andrew Swick, MS, PhD and wellness information. medical research. Scientific Advisory Board Richard Black, DO • John Boik, PhD • Aubrey de Grey, PhD These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Deborah F. Harding, MD • Steven B. Harris, MD • Sandra C. Kaufmann, MD Peter H. Langsjoen, MD, FACC • Dipnarine Maharaj, MD Customer care is available to take your calls L. Ray Matthews, MD, FACS • Ralph W. Moss, PhD 24 hours a day, 7 days a week: 1-800-678-8989 Michael D. Ozner, MD, FACC • Jonathan V. Wright, MD • Xiaoxi Wei, PhD Visit the Life Extension® Contributors Nutrition Center Store East Cypress Creek Rd. Michael Downey • William Faloon • Sarah Lewis N Dipnarine Maharaj, MD, FACP • Laurie Mathena Life Extension • The Most Complete Line of 2 Nutrition Center Jason Meyers • Stepanie Myers Life Extension Supplements Advertising • Blood Testing and Analysis Vice President of Marketing • Rey Searles • [email protected] Federal Highway • Personal Consultation with Atlantic Ocean National Advertising Manager • JT Hroncich • 404-347-4170 Life Extension Product/ East Commercial Blvd. Wellness Specialist Senior Director of Sales and Business Development Carolyn Bouchard • [email protected] • 954-202-7685 Nutrition Center of Florida, Inc., 5990 North Federal Highway, Circulation & Distribution Fort Lauderdale, FL 33308-2633 • Phone: 954-766-8144 Life Extension • 3600 West Commercial Blvd., Ft. Lauderdale, FL 33309 Hours: Monday-Friday 9 am-8 pm, Saturday 9 am-6 pm, Sunday 11 am-5 pm Editorial offices: 954-766-8433 • fax: 954-491-5306 Customer Service: 800-678-8989 • Email: [email protected] Wellness specialists: 800-226-2370 • Email: [email protected] #1 Rated Catalog/Internet Merchant—3-Time Winner Ratings based on results of Life Extension® Magazine values your opinion and welcomes feedback. the 2020 ConsumerLab.com survey Please mail your comments to Life Extension Magazine, Attn: of supplement users. More information at Letters to the Editor, PO Box 407198, Fort Lauderdale, FL 33340 www.ConsumerLab.com/survey. or email us: [email protected] LIFE EXTENSION (ISSN 1524-198X) Vol. 26, No. 7 ©2020 is published monthly except bi-monthly in April by LE Publications, Inc. at 3600 West Commercial Blvd., Fort Lauderdale, FL 33309-3338. LE Publications, Inc. All rights reserved. Published 13 times a year. Subscription rate: $40 per year in the United States. US $47 in Canada. US $60 in other countries. Mail subscriptions or address changes to: LE Publications, Inc., P.O. Box 407198, Fort Lauderdale, FL 33340-7198, USA. Or phone us toll-free at: 1-800-841-5433. Canada Subscriptions: Publications mail agreement num- ber 40028967. Return undeliverable Canadian addresses to PO Box 503, RPO West Beaver Creek, Richmond Hill, ON L4B4R6. You will be sent your first issue within six weeks after LE Publications, Inc. receives your subscription fee. Periodicals Postage paid at Fort Lauderdale, FL and at additional mailing offices. POSTMASTER: Send address changes to Life Extension, P.O. Box 407198, Ft. Lauderdale, Florida 33340-7198, USA. Printed in USA. The articles in this magazine are intended for informational purposes only. They are not intended to replace the attention or advice of a physi- cian or other health-care professional. Anyone who wishes to embark on any dietary, drug, exercise, or other lifestyle change intended to prevent or treat a specific disease or condition should first consult with and seek clearance from a qualified health-care professional. LEGAL NOTICE: Health claims contained in articles and advertisements in this publication have not been approved by the FDA with the exception of FDA-approved, qualified health claims for calcium, antioxidant vitamins, folic acid and EPA and DHA omega-3 fatty acids, and selenium as noted where applicable. Life Extension ® Magazine does not endorse any of the businesses or the products and/or services that may appear in advertisements for non-Life Extension branded products or services contained in it, except to state that they are advertisers who may have paid Life Extension for placement of an advertisement in this publication. Life Extension disclaims any and all responsibilities or warranties as to the accuracy of information contained in advertisements for non-Life Extension branded products or services. For Canadian customers send change of address information and blocks of undeliverable copies to P.O. Box 1051, Fort Erie, ON L2A 6C7. 2 | LIFE EXTENSION | JULY 2020 LEMJUL20p.indd 2 5/14/20 2:07 PM LLow-Costow-Cost Enzymatically Active Vitamins BioActive Complete B-Complex provides BBiologicallyiologically enzymatically active forms of meaningful AActivective potencies of each B vitamin. This includes the pyridoxal ’-phosphate form of vitamin B shown to protect lipids and proteins against glycation and the most biologically active form of folate called -methyltetrahydrofolate (-MTHF), which is up to times more bioavailable than folic acid.* Item # • vegetarian capsules CCOMPLEXOMPLEX bottle $ B bottles $ each For full product description and to order BioActive Complete B-Complex, call --- or visit www.LifeExtension.com Reference * Br J Pharmacol. 2004 Mar;141(5):825-30. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. LEMJUL20p.indd 3 5/13/20 4:55 PM MEDICAL ADVISORY BOARD Gustavo Tovar Baez, MD, operates the Life Mitchell J. Ghen, DO, PhD, holds a doc- Herbert Pardell, DO, FAAIM, practices internal Extension Clinic in Caracas, Venezuela. He is torate in holistic health and anti-aging medicine at the Emerald Hills Medical Center the first physician in Caracas to specialize in and serves on the faculty of medicine in Hollywood, FL. He is a medical director of anti-aging medicine. at the Benemerita Universidad Autonoma the Life Extension