PROGRAM GUIDE Aug. 3-6, 2017 | Boston, MA Co-organizers
The Center for Engineering in The American Society of Charlotte Banks is a research Medicine is headquartered at Mechanical Engineers represents initiative at the University of Massachusetts General Hospital an engineering community of more North Carolina Charlotte that and affiliated with Harvard and than 140,000 members worldwide. aims to cryopreserve whole MIT. organs and large tissues. Learn more at Learn more at asme.org Learn more at massgeneral.org/CEM charlottebanks.org
Partners
Society for Cryobiology X-therma, Inc. Ossium societyforcryobiology.org x-therma.com Health
Association of Organ International Institute for the Procurement Organizations Advancement of Medicine aopo.org iiam.org
Supporters
Principal Organizer
The Organ Preservation Alliance is a 501(c)3 non-profit dedicated to catalyzing breakthroughs in organ and tissue preservation. Learn more at organpreservationalliance.org Human Ingenuity + Human Tissue = Successful Research
IIAM provides non-transplantable, normal and diseased human organs and tissues authorized for purposes of medical research, education, and development. Human tissues in research enable the faster development of more efficacious drugs with improved safety profiles and enhanced understanding of basic disease processes that directly affect humans. Talk to us about your research needs by contacting Dolores Baldasare at [email protected] or 845-694-8440
800-486-IIAM (4426) www.iiam.org IIAM is a Non-Profit Organization Background on the Summit: Meeting a Grand Challenge
The Summit on Organ Banking through Converging Technologies brings together scientists, engineers, key stakeholders from government and industry, and leaders from non-profits focused on human health, with the aim of addressing the challenge of banking organs and large tissue systems for transplantation, research, regenerative medicine, and other applications. Together we will outline new and emerging research strategies that can overcome the remaining scientific sub-challenges in organ banking, with the hope of benefiting millions of patients each year worldwide.
“Millions of people each Organ “Organ banking would year worldwide Transplantation be perhaps the could benefit from Trauma Basic most important organ replacement. Care Research breakthrough in The public health transplantation implications in the last ORGAN of these Tissue Emergency 50 years.” BANKING technologies Engineering Preparedness RESEARCH are nothing short of - Dr. David Nelson Drug staggering.” Cancer Chief of Heart Transplantation, Care Discovery Baptist Integris Medical Center -Dr. George Church Reconstructive Former board member, Professor of Genetics, Surgery United Network of Organ Sharing, Harvard Medical School American Society of Transplantation
See organpreservationalliance.org/media for more background information, e.g. in: Venues
AUGUST 3 Hyatt Regency Boston, 3rd floor Martha’s Vineyard
AUGUST 4 Joseph B. Martin Conference Center, main auditorium Joseph B. Martin Conference Center Shuttles available: Harvard Medical School, 77 Avenue Louis Pasteur Hyatt front lobby, Boston, MA 02115 starting at 8:00 a.m.
AUGUST 5 Hyatt Regency Boston, 4th floor ballroom terrace
AUGUST 6 Hyatt Regency Hyatt Regency Boston Boston, 4th floor 1 Avenue de Lafayette ballroom terrace Boston, MA 02111 Program Agenda and Description AUGUST 4 AUGUST 5 AUGUST 6
Summit on Organ Banking through Converging Technologies: PART 1
The grand challenge of organ banking Outlining unmet needs and setting goals for organ banking research
Organ and tissue preservation presents a cross- in cryopreservation, hypometabolism, ex vivo cutting unmet need in biology and medicine. perfusion, and related areas. Diverse areas of public health would be transformed by advances in this field, spanning transplantation, During the Aug. 4 sessions, speakers from many of tissue engineering and regenerative medicine, fields of biomedicine affected will discuss ways that trauma care and emergency preparedness, this research effort can advance their respective cancer care, drug discovery, and basic biomedical areas. Special focus will be given to organ research. transplantation, which has already saved hundreds of thousands of patients through the heroic efforts While the benefits of preservation advances of organ procurement organizations, the United vary across these areas, their needs can be met Network of Organ Sharing, transplant centers, by a common set of technologies and research and others – even while facing severe logistical challenges. Just as agriculture, fertility, molecular constraints imposed by organ preservation times biology, and other areas were revolutionized by that are measured in hours. Leaders across many the ability to cryopreserve and bank cells, much of aspects organ transplantation will discuss what biomedicine could be revolutionized by the ability organ banking could mean for the ability of this to scale cryobanking to larger tissue systems and field to reach its lifesaving potential. whole organs. These speakers will be joined by experts in As one example, over 80% of the U.S. National cryopreservation, ex vivo perfusion and other Institutes of Health budget goes to institutes and fields. Together they will outline needs and goals centers whose missions are directly impacted for organ banking research, setting the stage by the “organ banking” research effort. This for a cohesive organ banking “Apollo Program” effort aims to make fundamental advances to distributed across research labs and clinics extend preservation times across a variety of worldwide. organ and tissue systems, combining advances AUGUST 4 AUGUST 5 AUGUST 6
Session 1: The grand challenge of organ banking
SESSION CHAIR AND MODERATOR: LOCATION: Dr. Andrew Marshall Joseph B. Martin Chief Editor, Nature Biotechnology Conference Center Ampitheater
Introduction: the Jedediah Lewis 9:00 promise of organ and President and Chief Executive Officer, tissue preservation to Organ Preservation Alliance transform medicine
Organ banking 101 Dr. Erik Woods 9:15 Crash course talk Past President, Society for Cryobiology Chief Science Officer and Co-founder, Ossium Health
Dr. Sebastian Giwa 9:35 Is organ banking within reach? Chairman and Co-founder, Organ Preservation Alliance, Sylvatica Biotech, Ossium Health
Achieving organ 9:55 Dr. Korkut Uygun Dr. Shaf Keshavjee banking: proofs of Assistant Professor, Professor, principle and paths Harvard Medical School University of Toronto forward Deputy Director of Chief Medical Officer, Lightning talks and Research, Perfusix panel discussion Shriners Hospitals for Children Dr. Kenneth Storey MODERATOR: Dr. Greg Fahy Professor, Dr. Andrew Marshall Carleton University Chief Editor, Chief Science Officer, 21st Century Medicine Canada Research Chair Nature Biotechnology in Molecular Physiology Dr. Nir Shani PANELISTS: Dr. John Bischof Dr. Helen Picton Director, Professor, Microsurgery and Plastic University of Minnesota Professor, Surgery Lab, Leeds University School Tel Aviv Sourasky Medical of Medicine Center AUGUST 4 AUGUST 5 AUGUST 6
Enabling organ banking Dr. Mehmet Toner 10:40 by combining the best of Professor, academia and the best Harvard Medical School of industry
Networking Break 10:55 Snacks and Beverages
Session 2: Steps toward realizing organ transplantation’s full potential
SESSION CHAIR AND MODERATOR: LOCATION: Dr. Joren Madsen Joseph B. Martin Director, Transplant Center, Massachusetts General Hospital Conference Center Past President, American Society of Transplantation Ampitheater Associate Editor, American Journal of Transplantation
Fireside chat with Charity Sunshine Dr. Sebastian Giwa 11:25 Tillemann-Dick Charity Sunshine Chairman and Co-founder, Tillemann-Dick Professional opera singer Organ Preservation Alliance, Two-time double lung Sylvatica Biotech, transplant recipient Ossium Health
Transforming Dr. James Markmann 11:50 transplantation through (recorded remarks) ex vivo preservation and Chief, Division of Transplantation, organ banking Massachusetts General Hospital
Bringing Dr. Gerald Brandacher 12:00 transplantation Scientific Director, to new frontiers Johns Hopkins Reconstructive Transplantation Program
Logistical needs in Elling Eidbo 12:10 organ recovery and Chief Executive Officer, transplantation Association of Organ Crash course talk Procurement Organizations AUGUST 4 AUGUST 5 AUGUST 6
Taking advantage Dr. David Klassen 12:25 of increased organ Chief Medical Officer, preservation time: United Network of Organ OPTN/UNOS Sharing perspectives
Envisioning a new Dr. Shaf Keshavjee 12:40 logistical framework Professor, for organ recovery and University of Toronto transplantation Chief Medical Officer, Perfusix
The impact of PANELISTS: 12:55 organ banking on David Hartell Elling Eidbo transplantation Executive Director, Chief Executive Officer, Panel discussion Canadian National Association of Organ Transplant Research Procurement Organizations MODERATOR: Program Dr. Joren Madsen Dr. Gerald Brandacher Dr. David Klassen Director, Transplant Associate Professor of Center, Chief Medical Officer, Plastic and Reconstructive Massachusetts General United Network of Organ Surgery, Hospital Sharing Johns Hopkins School of Medicine Past President, Dr. Shaf Keshavjee American Society of Dr. David Nelson Transplantation Professor, University of Toronto Chief of Heart Associate Editor, Transplantation, American Journal of Chief Medical Officer, Perfusix Baptist Integris Medical Transplantation Center
Lunch Main Lobby 1:25 AUGUST 4 AUGUST 5 AUGUST 6
Session 3: Enabling diverse new technologies through organ banking
SESSION CHAIR AND MODERATOR: LOCATION: Dr. Orla Smith Joseph B. Martin Editor, Science Translational Medicine Conference Center Ampitheater
Off-the-shelf Dr. George Church 2:20 xenotransplantation: Professor, making “organs on Harvard Medical School demand” a reality
Immune tolerance Dr. David Sachs 2:40 induction through (recorded remarks) organ banking: moving Professor, transplantation from a Columbia University treatment to a cure School of Medicine Professor Emeritus, Harvard Medical School
Envisioning new 2:55 PANELISTS: possibilities for regenerative medicine Rony Thomas Dr. Anthony Letai and research Chief Executive Officer, Associate Professor, Panel discussion LifeNet Health Harvard Medical School Dr. Wendy Dean Dr. Claudia Zylberberg MODERATOR: Dr. Orla Smith Medical Officer, Tissue Chief Executive Officer, Injury and Regenerative Carleton University Akron Editor, Medicine Program, Biotech Science Translational U.S. Department of Medicine Defense Gina Dunne Smith Executive Director, International Institute for the Advancement of Medicine
3:20 Department of Dr. Wendy Dean Defense interest in Medical Officer, Tissue Injury and tissue preservation and Regenerative Medicine Program, biomanufacturing U.S. Department of Defense AUGUST 4 AUGUST 5 AUGUST 6
Dr. Clark Colton 3:35 Increasing the quality and shelf-life of Professor, pancreatic islets: Massachusetts Institute of Technology What we learned from encapsulation studies
Perspectives on ovarian 3:50 Dr. Helen Picton and testicular tissue Professor, cryopreservation Leeds University School of Medicine
Networking Break 4:05 Snacks and Beverages
Session 4: Meeting a grand challenge
SESSION CHAIR AND MODERATOR: LOCATION: Dr. Robert Kruger Joseph B. Martin Editor, Cell Conference Center Ampitheater
Fireside chat: How Dr. Ed Boyden Dr. Robert Kruger 4:35 to think about large- Assistant Professor, Editor, scale challenges in Massachusetts Institute Cell biomedicine of Technology 2016 Breakthrough Prize recipient
Charlotte Banks: first Dr. Gloria Elliott 5:05 steps toward building Professor, a convergence-based University of North Carolina Charlotte research program Director, Charlotte Banks Research Initiative
Launching an organ Jedediah Lewis 5:15 banking Apollo Program President and Chief Executive Officer, Organ Preservation Alliance
Poster session, Main Lobby 5:30 Networking and cocktails New Research Building, Harvard Medical School AUGUST 4 AUGUST 5 AUGUST 6
Summit on Organ Banking through Converging Technologies: PART 2
The scientific deep dive Designing an organ banking Apollo Program
These “deep dive” sessions have two objectives:
1. To allow those outside the field to become Talks are intended to be short, jargon-free, familiar with the remaining scientific and and kept at the level of an overview. The engineering challenges of organ banking. For aim is to focus on articulating the overall instance, new researchers will gain knowledge approach, proofs of principle, and reasons they need to launch projects in the organ banking for optimism that the approach could yield space, while potential funders, investors, and progress. At the end of every session, other supporters will gain an understanding of an interactive panel Q&A will allow for the kinds of projects they can help accelerate. collaborative brainstorming among session speakers and audience members, with 2. To allow researchers from diverse the main goal of (together) answering the backgrounds to gain insight into each other’s question: approaches and identify opportunities for collaboration. Speakers from within the fields of cryopreservation and organ preservation will give “How could these approaches talks along with many researchers completely new and technologies be leveraged to this challenge, integrating knowledge from to create organ banking many domains (engineering, physics, chemistry, breakthroughs?” cell and molecular biology, computational biology, pathology, etc.). AUGUST 4 AUGUST 5 AUGUST 6
Session 5: Limiting cryoprotectant and osmotic toxicity
SESSION CO-CHAIRS: LOCATION: Dr. Janet Elliott Dr. Greg Fahy Hyatt Regency Boston Professor, University of Alberta Chief Science Officer, 4th floor grand ballroom Canada Research Chair in 21st Century Medicine Thermodynamics Associate Editor, Cryobiology
Welcome, agenda, session Jedediah Lewis 8:00 format President and Chief Executive Officer, Organ Preservation Alliance
Ice formation and cryoprotectant Dr. Janet Elliott 8:10 toxicity in tissue cryopreservation Professor, Crash course talk University of Alberta Canada Research Chair in Thermodynamics Associate Editor, Cryobiology
Cooling injury in rabbit kidneys Dr. Greg Fahy 8:30 below -22°C Chief Science Officer, 21st Century Medicine
Mechanisms of intracellular ice Dr. Jens Karlsson 8:40 formation in tissues Professor, University of Villanova
Designing the next generation of Dr. Robert Ben 8:50 cryoprotectants to meet the needs Professor, for emerging cellular therapies and University of Ottawa tissue engineering
Ice-binding-proteins and their Dr. Ido Braslavsky 9:00 interaction with ice crystals Professor, Hebrew University of Jerusalem
Development of organ perfusion Dr. Adam Higgins 9:10 strategies to reduce CPA toxicity Associate Professor, Oregon State University AUGUST 4 AUGUST 5 AUGUST 6
Interactive panel discussion Dr. Greg Fahy , Dr. Jens Karlsson, 9:20 and Q&A Dr. Robert Ben, Dr. Ido Braslavsky and Dr. Adam Higgins
Networking Break 9:45 Snacks and Beverages
Session 6: Strategies for controlling physical effects during organ cryobanking
SESSION CHAIR: LOCATION: Dr. Yoed Rabin Hyatt Regency Boston Professor, Carnegie Mellon University 4th floor grand ballroom
Physical effects in cryopreservation: Dr. Yoed Rabin 10:15 an engineering approach Professor, Crash course talk Carnegie Mellon University
Nanoparticle heating for improved Dr. John Bischof 10:35 cell and tissue preservation Professor and Department Chair, University of Minnesota Associate Director, Institute for Engineering in Medicine
Ice-free vitrification of complex Dr. Kelvin Brockbank 10:45 large tissues Chief Executive Officer, Tissue Testing Technologies
Thawing for cryopreserved Dr. Girish Srinivas 10:55 tissues Partner and Director of Technology, TDA Research
Factors affecting the success Dr. Nir Shani 11:05 of organ cryobanking Director, Microsurgery and Plastic Surgery Lab, Tel Aviv Sourasky Medical Center AUGUST 4 AUGUST 5 AUGUST 6
Interactive panel discussion Dr. Yoed Rabin , Dr. John Bischof, 11:15 and Q&A Dr. Kelvin Brockbank, Dr. Girish Srinivas and Dr. Nir Shani
Banquet Lunch 4th floor ballroom terrace 11:35
Session 7: Nature-inspired induction of hypometabolism
SESSION CHAIR: LOCATION: Dr. Kenneth Storey Hyatt Regency Boston Professor, Carleton University 4th floor grand ballroom Canada Research Chair in Molecular Physiology
Turning the switch to OFF: Dr. Kenneth Storey 12:35 hypometabolism of organs at Professor, Carleton University any temperature Canada Research Chair in Crash course talk Molecular Physiology
Hacking temperature to extend Dr. Korkut Uygun 12:55 and enhance preservation Assistant Professor, Harvard Medical School Deputy Director of Research, Shriners Hospitals for Children
Partial freezing: a nature-inspired Dr. Shannon Tessier 1:05 strategy for organ banking Research fellow, Mehmet Toner Lab, Massachusetts General Hospital
Identification of non-coding RNAs Dr. Pier Jr. Morin 1:15 modulated at low temperatures in Associate Professor, animal models of cold adaptation Université de Moncton
Preserving vascular function during Dr. Guillermo García-Cardeña 1:25 organ procurement and storage Associate Professor, guided by physiological systems Harvard Medical School AUGUST 4 AUGUST 5 AUGUST 6
Interactive panel discussion and Dr. Kenneth Storey, Dr. Korkut Uygun, 1:35 Q&A Dr. Shannon Tessier, Dr. Pier Jr. Morin and Dr. Guillermo García-Cardeña
Break 1:55
Session 8: Protecting key biological systems during organ banking
SESSION CO-CHAIRS: LOCATION: Dr. Janet Elliott Dr. Julie Stacey Hyatt Regency Boston Professor, University of Alberta Editor-in-Chief, 4th floor grand ballroom Canada Research Chair in EBioMedicine Thermodynamics Associate Editor, Cryobiology
Cryopreservation of Dr. Janet Elliott 2:00 endothelial cells Professor, University of Alberta Canada Research Chair in Thermodynamics Associate Editor, Cryobiology
Copolymer surfactant catalyzed Dr. Raphael Lee 2:10 membrane sealing linked to Professor, reduction in interfacial tension University of Chicago
Cell adhesion and Dr. David Calderwood 2:20 the cytoskeleton Associate Professor, Yale School of Medicine
Interactive panel discussion Dr. Janet Elliott, Dr. Raphael Lee 2:30 and Q&A and Dr. David Calderwood MODERATOR: Dr. Julie Stacey Editor-in-Chief, EBioMedicine
Break 2:45 AUGUST 4 AUGUST 5 AUGUST 6
Session 9: Enhancing stress tolerance and aiding tissue recovery
SESSION CHAIR: LOCATION: Dr. John G. Baust Hyatt Regency Boston Professor, 4th floor grand ballroom Binghamton University, State University of New York
Understanding cryoinjury Dr. John G. Baust 3:15 and cell stress pathways Professor, Crash course talk Binghamton University State University of New York
Enhancing stress tolerance Dr. John M. Baust 3:35 and aiding recovery Chief Executive Officer, CPSI Biotech
Utilizing the amino acid response Dr. Malcolm Whitman 3:45 to induce organ cytoprotection Professor, Harvard Medical School
Prophylactic treatment of Dr. Ivan Sammut 3:55 ischaemically stored organs with Associate Professor, novel organic carbon monoxide University of Otago donor molecules
Nanomedicine for improving cell Dr. Thomas Webster 4:05 and tissue preservation Professor and Department Chair, Northwestern University
Induction of synthetic lethality Dr. Markus Siegelin 4:15 in glioblastoma Assistant Professor, Columbia University Medical Center AUGUST 4 AUGUST 5 AUGUST 6
Interactive panel discussion Dr. John G. Baust, Dr. John M. Baust, 4:25 and Q&A Dr. Malcolm Whitman, Dr. Ivan Sammut, Dr. Thomas Webster and Dr. Markus Siegelin
Break 4:50
Breakthrough Ideas in Organ Banking 4:55 Hackathon: Finalist Presentations
Break 5:40
Cocktail reception 7:30 4th floor foyer AUGUST 4 AUGUST 5 AUGUST 6
Session 10: Unlocking a new world of transplant capabilities through organ perfusion platforms
SESSION CHAIR: LOCATION: Dr. Barry Fuller Hyatt Regency Boston Professor, 4th floor grand ballroom University College London Medical School
Morning announcements Jedediah Lewis 8:00 President and Chief Executive Officer, Organ Preservation Alliance
Organ perfusion technologies Dr. Barry Fuller 8:05 - improving the physiology of Professor, transplant preservation and University College London Medical School creating opportunities for organ cryopreservation? Crash course talk
How to create and measure Dr. Jayan Nagendran 8:25 normal physiology outside of the Assistant Professor and Director of body Research, Division of Cardiac Surgery, University of Alberta
Ovine model of prolonged Dr. Álvaro Rojas-Peña 8:35 normothermic ex situ heart Assistant Research Scientist and perfusion and support for 72 Extracorporeal Life Support hours Laboratory Manager, University of Michigan
Novel, non-obvious applications Dr. Michael Taylor 8:45 of perfusion technology Chief Science Officer, Sylvatica Biotech
Gaseous oxygen perfusion as an Dr. Klearchos Papas 8:55 organ preservation method Professor, University of Arizona College of Medicine AUGUST 4 AUGUST 5 AUGUST 6
Interactive panel discussion Dr. Barry Fuller, Dr. Jayan Nagendran, Dr. 9:05 and Q&A Álvaro Rojas-Peña, Dr. Michael Taylor and Dr. Klearchos Papas
Networking Break 9:25 Snacks and Beverages
Session 11: Assessing preservation needs and outcomes
SESSION CHAIR: LOCATION: Dr. Jason Acker Hyatt Regency Boston President, Society for Cryobiology 4th floor grand ballroom Professor, University of Alberta
3D imaging of whole organs Todd Huffman 9:55 at single-cell resolution Chief Executive Officer, 3Scan
Measuring viability and Dr. Clark Colton 10:05 functional status of tissues for Professor, transplantation Massachusetts Institute of Technology
Should consideration be given to the Dr. Jason Acker 10:15 role that donor factors may play in President, the cryobiological response of cells, Society for Cryobiology tissues and organs? Professor, University of Alberta
Molecular mapping of tissue Dr. Peggi Angel 10:25 histological features by imaging mass Assistant Professor, spectrometry as a tool for tissue and Medical University of South Carolina organ transplant studies
Interactive panel discussion Todd Huffman, Dr. Clark Colton, 10:35 and Q&A Dr. Peggi Angel and Dr. Jason Acker
Break 10:55 AUGUST 4 AUGUST 5 AUGUST 6
Session 12: New tools for organ cryopreservation
SESSION CHAIR: LOCATION: Dr. Ramón Risco Delgado Hyatt Regency Boston Professor, Universidad de Sevilla 4th floor grand ballroom Research Director and Founder, Safe Preservation
Pressure-aided preservation: Dr. Brad Weegman 11:00 adding thermodynamic Lab Director, degrees of freedom Sylvatica Biotech
XT-ViVoTM-next generation nature- Dr. Xiaoxi Wei 11:10 inspired ice prevention for better Chief Executive Officer, biobanking X-Therma
Avoiding recrystallization in Dr. Ramón Risco Delgado 11:20 organs by selective targeting of Professor, ice through magnetic ice-binding Universidad de Sevilla proteins Research Director and Founder, Safe Preservation
Non-newtonian, shear-thickening Dr. Peter Kilbride 11:30 behaviour with cryoprotectant Senior Research Scientist, solutions Asymptote Ltd.
Interactive panel discussion Dr. Brad Weegman, Dr. Xiaoxi Wei, 11:40 and Q&A Dr. Ramón Risco Delgado and Dr. Peter Kilbride MODERATOR: Dr. Luis Alvarez Director, Organ Manufacturing United Therapeutics
Closing, 12:00 Hackathon winners announced Notes: Proudly sponsored by
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Creating tissue cellular and regenerative medicine solutions that save lives, restore health, LifeNet Health Institute of and give hope to REGENERATIVE millions. MEDICINE
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For other sponsors who helped make this summit possible, see page 2.