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Certificate ISO 14001 From CERTIFICATE This is to certify that Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany with the organizational units/sites as listed in the annex has implemented and maintains an Environmental Management System. Scope: Development, production and distribution of pharmaceuticals, chemical products and analytical systems. Through an audit, documented in a report, it was verified that the management system fulfills the requirements of the following standard: ISO 14001 : 2015 Certificate registration no. 005356 UM15 Valid from 2020-12-17 Valid until 2023-12-16 Date of certification 2020-11-18 DQS GmbH Markus Bleher Managing Director Accredited Body: DQS GmbH, August-Schanz-Straße 21, 60433 Frankfurt am Main, Germany 1 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 005356 Development, production and distribution of Merck KGaA pharmaceuticals, chemical products and Frankfurter Straße 250 analytical systems. 64293 Darmstadt Including: Real Estate GmbH Merck Performance Materials Germany GmbH Merck Healthcare KGaA With regional offices at: Roesslerstrasse 96 64293 Darmstadt Waldstrasse 3 64331 Weiterstadt 450237 Merck S.A. Production and distribution of pharmaceuticals Estrada dos Bandeirantes, 1099 and chemical products. Rio de Janeiro - RJ 22710-571 Brazil 450240 Merck Serono SA Production and distribution of Zone Industrielle de l´Ouriettaz pharmaceuticals. 1170 Aubonne Switzerland 450325 Merck Serono SA Development and production of Corsier-sur-Vevey pharmaceuticals. Rte de Fenil 25 1804 Fenil-sur-Vevey Switzerland This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 2 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 450241 Merck & Cie Production of chemical products. Weisshausmatte 6460 Altdorf Switzerland 450324 Merck & Cie Development and production of chemical Im Laternenacker 5 products. 8200 Schaffhausen Switzerland 527490 Sigma-Aldrich Chemie GmbH Development, manufacturing and distribution Industriestrasse 25 of reagents and chemicals for research, 9470 Buchs SG development, production and analytical Switzerland purposes. 530377 Sigma-Aldrich Production GmbH Development, manufacturing and distribution Industriestrasse 25 of reagents and chemicals for research, 9470 Buchs SG development, production and analytical Switzerland purposes. 514696 Merck Display Materials (Shanghai) Ltd. Design, development, manufacture and First Floor and Second Floor Area B of distribution of liquid crystal materials; 14th Building East Side and 15th building, distribution of other chemical materials. No. 211 Qinqiao Road, Free Trade Zone 201206 Shanghai P.R. China 518298 Merck Electronic Materials (Suzhou) Ltd. Production of photoresist products, edge bead No. 70, Longpu Road, Industrial Park rinse thinner, remover used for electronic 215021 Suzhou City, Jiangsu Province industry. P.R. China This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 3 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 543386 Merck Pharmaceutical Manufacturing Pharma manufacturing (production and (Jiangsu) Co., Ltd. package). No. 168 Hexing Road NETDA 226010 Nantong, Jiangsu P.R. China 527728 Sigma-Aldrich Biochemie GmbH Development, manufacturing and distribution Georg-Heyken-Strasse 14 of reagents for the synthesis of 21147 Hamburg oligonucleotides and other Life Science Germany Products. 240237 Merck KGaA Development, production and distribution of Mainzer Strasse 41 chemical products. 64579 Gernsheim Germany 518299 Merck Performance Materials GmbH Design and development, production and Rheingaustrasse 190 - 196 supply of photoresist and process chemicals 65203 Wiesbaden for the electronic and printing industry. Germany 505611 Merck Life Science GmbH Development, manufacture and distribution of Lilienthalstrasse 16 culture media and systems for microbiology. 69214 Eppelheim Germany 002955 Merck Schuchardt OHG Production and distribution of chemical Eduard-Buchner-Strasse 14 - 20 products. 85662 Hohenbrunn Germany This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 4 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 527592 Sigma-Aldrich Produktions GmbH Development and production of Riedstrasse 2 pharmaceuticals, chemical products and 89555 Steinheim analytical systems. Germany 527503 Sigma-Adrich Chemie GmbH Production and distribution of Riedstrasse 2 pharmaceuticals, chemical products and 89555 Steinheim analytical systems. Germany 450321 Merck S.L.U. Production and distribution of pharmaceuticals Polígono Industrial Merck and chemical products. 08100 Mollet del Valles (Barcelona) Spain 426638 Merck S.L.U. Development and production of Calle de Batanes No 1 pharmaceuticals. 28760 Tres Cantos (Madrid) Spain 450274 Merck Biodevelopment S.A.S. Development and production of biological 1 rue Jacques Monod molecules for therapeutic use. 33650 Martillac Cedex France 478742 Merck Santé S.A.S. Development and production of Le Pressoir Vert pharmaceuticals. 45402 Semoy France This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 5 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 518302 Merck Performance Materials SAS Design, production and sale of colloidal silica L'Usine de la Motte 1 Rue du Flottage 60350 Trosly Breuil France 450275 Merck Santé S.A.S. Production of chemical products. 5, rue Clément Ader 62100 Calais France 492648 Millipore S.A.S. Manufacturing of devices and media for fluid 39, Route Industrielle de la Hardt analysis and purification. 67120 Molsheim Manufacturing of water purification systems for France laboratories. Engineering of filtration equipment. Validation and scientific support to users. 450276 Merck Santé S.A.S. Production of chemical products and 10 Av. de Lattre de Tassigny distribution of pharmaceuticals. 69330 Meyzieu France 527761 Sigma-Aldrich Co. Ltd. Manufacture of custom oligonucleotides. Sales Homefield Road and support of custom biomolecules and life Haverhill, Suffolk science research products. CB9 8QP United Kingdom This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 6 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 505626 Millipore (UK) Ltd. Development, manufacture and sale of clinical 3 Fleming Road diagnostic products derived from biological Kirkton Campus sources products and cell culture media and Livingston reagents. EH54 7BN United Kingdom 527496 Sigma-Aldrich Co. Ltd. The manufacture of cell culture related critical T/A SAFC raw materials for the global health care Second Avenue industry. Heatherhouse Industrial Estate Irvine KA12 8NB United Kingdom 450286 P.T. Merck Tbk. Development, production and distribution of Jl. TB. Simatupang no. 8 pharmaceuticals and chemical products. Pasar Rebo Jakarta 13760 Indonesia 540290 PT Merck Chemicals and Life Sciences Sales, marketing and distribution of Life Jl. TB. Simatupang No. 8 Science and Performance Material products. Pasar Rebo Jakarta 13760 Indonesia 518300 Merck Performance Materials Pvt. Ltd. Design, development, manufacturing, Khopoli Site marketing and sales of silicon resins Survey No 109, 110, 112 Savroli Village, (polysilazanes and silazanes) and Taluka Khalapur, Dist. Raigad formulations. Maharashtra 410 203 India This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 7 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 501956 Merck Life Science Private Limited Manufacturing of filtration equipment and 50 A & 51, 2nd Phase, Ring Road, Peenya related products for biopharm, process Bangalore 560 058 solutions, biomonitoring, lab water, bioscience, India laboratory testing, validation and compliance services. 530393 Sigma Aldrich Chemicals Private Limited Development, manufacture, sales and # 12, Bommasandra Jigani Link Road distribution of specialty and fine chemicals. Bangalore, Karnataka State 560100 India 505619 Merck Millipore Ltd. Manufacture of filtration products for the Tullagreen pharmaceutical, food, beverage, electronic Carrigtwohill and analytical industries. Manufacture of T45 KD29 County Cork chromatography adsorbents, immobilized Ireland enzymes and other ligands for modification and purification of biomolecules. 527495 Sigma-Aldrich Ireland Ltd. The manufacture and supply of advanced Vale Road pharmaceutical intermediates and active Arklow, County Wicklow pharmaceutical ingredients and the Ireland procurement, sales and distribution of reagents and chemicals for research, development, production and analytical purposes. 450291 Inter-Lab Ltd. Development and distribution of Hakishon St. No. 18 pharmaceuticals. 81220 Yavneh 81101 Israel This annex (edition: 2020-11-18) is only valid in connection with the above-mentioned certificate. 8 / 19 Annex to certificate Registration No. 005356 UM15 Merck KGaA Frankfurter Strasse 250 64293 Darmstadt Germany Location Scope 527758 Sigma-Aldrich Israel Ltd. Development and manufacture
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