INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary Report

SEIZED MATERIALS 2015/1 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3 NPS reported by ICE participants Page 4 Codes and Abbreviations Page 7 Sample 1 Analysis Page 8 Identified substances Page 8 Statement of findings Page 12 Identification methods Page 21 Summary Page 26 Z-Scores Page 27 Sample 2 Analysis Page 31 Identified substances Page 31 Statement of findings Page 35 Identification methods Page 44 Summary Page 49 Z-Scores Page 50 Sample 3 Analysis Page 53 Identified substances Page 53 Statement of findings Page 55 Identification methods Page 60 Summary Page 65 Sample 4 Analysis Page 66 Identified substances Page 66 Statement of findings Page 71 Identification methods Page 80 Summary Page 85 Z-Scores Page 86 Full test Samples Information

Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 5.2 % (w/w) cocaine base. The test sample also contained glucose, caffeine, lidocaine, procaine and trace amounts of creatine and levamisole.

Sample 2 SM-2 was prepared from a seizure containing 5.5 % (w/w) amfetamine base. The test sample also contained caffeine and creatine.

Sample 3 SM-3 was a blank test sample containing no substances from the ICE menu.

Sample 4 SM-4 was prepared from a seizure containing 72.2%(w/w) heroin base. the seizure also contained acetylcodeine, 6-monoacetylmorphine, papaverine, noscapine and trace amounts of morphine.

Samples Substances to be identified from ICE menu Concentrations Comments on substances Sample 1 Caffeine 0 % quantification not required Cocaine 5.2 % Lidocaine (Lignocaine) 0 % quantification not required Procaine 0 % quantification not required Sample 2 Amfetamine 5.5 % Caffeine 0 % quantification not required Sample 3 [blank sample] Sample 4 Heroin 72.2 % Morphine minor component 0 % quantification not required

Introduction

An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries, to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enables UNODC to tailor technical support in the laboratory sector for greatest impact.

Comments from the International Panel of Forensic Experts

Participation of Laboratories

In the 2015/1 round of the ICE programme, results were submitted within both the Seized materials (SM) and Biological Specimens (BS) test groups by 207 laboratories in 66 countries. Within the SM test group, there were 177 participating laboratories from 65 countries and within the BS test group, results were submitted by 85 laboratories from 46 countries.

Qualitative Analysis

The analytical technique most commonly used for screening of test samples in the SM test group was the marquis reagent (41% of participants), while GC-MS (90%) was the most commonly used technique for identification/confirmation of the components in the test samples followed by FTIR (36%). The results for the qualitative identification of the controlled substances were excellent for all test samples in the SM group as shown in the table 1.

Table 1. Performance of participants for the qualitative analysis in the 2015/1 round of ICE.

SM-1 SM-2 SM-4 Test sample (Cocaine) (Amfetamine) SM-3 (Blank) (Heroin) Correct identification 98% 92% N/A 98% by participants

With regard to the false positive results for controlled substances in the ICE menu there were a total of thirteen, (two each for SM-1 and SM-4, three for SM-2 and six for the blank test sample of plant material (SM-3). There were a total of eighteen false negative results in the three SM test samples containing controlled substances, 67% of which were for SM-2 where the amfetamine was not identified. While the overall number of false positive/negative results reported by ICE participants is encouragingly low, Laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken in order to continuously improve performance.

Quantitative Analysis

The proportion of participants who carried out quantitative analysis, 127 (72%) for SM-1, 93 (53%) for SM-2 and 122 (69%) for SM-4 continues to be encouraging, particularly the high percentage of participants who quantified the cocaine in SM-1. It is also encouraging to note that 130 (73%) of participants in the SM test group performed quantitation and of these, 94 (72%) quantified all three test samples. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 53% used GC-FID, 27% used HPLC and 19% used GC-MS. z-scores obtained by participants in quantification are shown in the table 2 (Percentage and number of laboratories are indicated).

Table 2. Performance of participants for quan titative analysis in the 2015/1 round of ICE .

Test sample z-score SM-1 (Cocaine) SM-2 (Amfetamine) SM-4 (Heroin) |z| < 2, satisfactory 81% (103) 82% (76) 80% (98) 2 ≤ |z| ≤ 3, questionable 7% (9) 6% (6) 7% (7) |z| > 3, unsatisfactory 12% (15) 12% (11) 12% (12)

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation. Participants with z-scores outside acceptable limits should review their quantification procedures.

In the 2014/2 round of ICE, nine laboratories obtained questionable z-scores with 2 ≤ |z| < 3. Of these laboratories, eight (100%) who performed quantification obtained acceptable z-scores with |z| < 2 in the current 2015/1 round of ICE for at least one substance. However, two of these laboratories still obtained questionable z-scores and two laboratories also obtained unsatisfactory z-scores in 2015/1.

Fourteen laboratories obtained unsatisfactory z-scores in ICE 2014/2 with |z| ≥ 3, and of these, ten (71%) improved their performance in quantification in the current 2015/1 ICE round in at least one substance, although seven (50%) still obtained unsatisfactory z-scores in at least one substance in 2015/1.

Laboratories that need to perform quantitation routinely are encouraged to participate regularly in external proficiency testing or collaborative exercises such as the ICE programme. This will enable laboratories to assess the quality of their quantitative methods through the z-score values obtained. Laboratories reporting false positive or false negative results should investigate the root causes and corrective actions taken promptly in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions. UNODC would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme.

New Psychoactive Substances (NPS) reported by laboratories participating in the 2015/1 round of the ICE programme

During the 2015/1 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 246 reports of 118 substances. The most commonly reported substances were synthetic cannabinoids (33%) followed by synthetic cathinones (29%) and phenethylamine group substances (19%) as shown in figure 1. In general, this is the same trend that was reported in the 2014/2 round of ICE.

2% 2% 2% Synthetic cannabinoids 9% Phenethylamines 4% 33% Synthetic cathinones

Tryptamines

Others

Piperazines 29% Ketamine and phencyclidine type substances 19% Aminoindanes

Figure 1. NPS reported by ICE laboratories during the 2015/1 round of ICE

NPS most commonly reported by laboratories participating in ICE 2015/1

The substance most often reported by ICE participants was the synthetic cathinone methylone followed by the phenethylamines DOC (2,5-Dimethoxy-4-chloroamphetamine) and 25I-NBOMe. These were followed by the synthetic cannabinoids, 5F-AKB-48 and AB-CHMINACA. All these are shown in table 3.

Table 3. NPS most commonly reported by ICE participants in the 2015/1 round of ICE

Substance IUPAC name Structure

1-(1,3-benzodioxol-5-yl)-2- Methylone (methylamino)propan-1-one

2-(4-iodo-2,5-dimethoxyphenyl)-N-(2- 25I-NBOMe methoxybenzyl)ethan-1-amine

1-(4-chloro-2,5-dimethoxyphenyl)propan-2- DOC amine

N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H- 5F-AKB-48 indazole-3-carboxamide

(S)-N-(1-amino-3-methyl-1-oxobutan-2-yl)-1- AB-CHMINACA (cyclohexylmethyl)-1H-indazole-3-carboxamide

ICE participants can obtain further details of all the NPS reported to UNODC by logging on to the UNODC ICE portal and selecting the icon for the Early Warning Advisory on New Psychoactive Substances

6 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Codes and Abbreviations

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained. (-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.

Tech Code Name 140 Colorimetric reactions 141 Marquis reagent (sulphuric acid, formaldehyde) 142 Cobalt thiocyanate 150 Thin Layer Chromatography 160 High/Ultra High Performance Liquid Chromatography 161 High Performance Liquid Chromatography with diode array detection 170 Gas Chromatography NPD 171 Gas Chromatography FID 172 Gas Chromatography ECD 180 Gas Chromatography/Mass Spectrometry 190 Fourier Transform Infrared Spectrometry 200 Spectrophotometry (visible, UV) 210 Others (specify) 211 NMR 220 Microcrystal test 230 Liquid chromatography/mass spectrometry 231 Liquid chromatography/tandem mass spectrometry

Sample 1 Analysis

Identified substances for Test Sample 1

Code Identified Substances 0B00MA COCAINE 0BPIQK Cocaine 15KHZZ Cocaine 1NBQEB cocaine 1OFS4X Cocaine 1X1W9X Cocaine 20222K Cocaine 2C5GCK Cocaine 2JJEMT cocaine, procaine, lidocaine, caffeine 2KHKFK cocaine 333WNF Cocaine, Lidocaine, Procaine, Caffeine 3I4END Cocaine 3XMCSS COCAINE 4IHDMJ cocaine 4MQGMT cocaine 4QDDDD cocaine hydrochloride 4WAP4I cocaine 5B9R5Q Cocaine 5D5Q5X COCAINE 6HXWOM Cocaine 6I9L3N cocaine 6P0WWW Cocaine, Caffeine, Lidocaine and Procaine 6TZBOI cocaine 72SXT7 Cocaine 7CVHQG Cocaine 88CBR8 Cocaine 8EKCQE cocaine 8P8J9S Cocaine 8Z1D82 Cocaine 999FTE cocaine 9AQQ5Z Cocaine 9E9RV9 Cocaine, Caffeine, Lidocaine and Procaine 9G1IGG cocaine A55MTH cocaine AFUPAX Cocaine HCl AG4RDN Cocaine AGX9RJ Cocaine AM75RV Cocaine, Procaine, Lidocaine and Caffeine ASAZSF Cocaine ATMMIK Cocaine

Code Identified Substances AXEI96 Cocaine, Lidocaine, Procaine and Caffeine BCQF5M cocaine BFDDDR Cocaine BUBXUF COCAÍNE C0ZZJN COCAINE C77B7S cocaine CLWMLL cocaïne CML6FN Cocaine CRVCAC cocaine,caffeine,lidocaine,procaine DF8IPB cocaine DPMUDD Cocaine, purity 5% DSTAS1 COCAINE DXGEZT cocaine EAEWNG cocaine EGOAAA cocaine EH8THK Cocaine EIUUUK cocaine EK1CYF Cocaine EKXNNH cocaine ERGL66 cocaine, caffeine, lignocaine, procaine FG6OYO cocaine FSLFBU Cocaine FSOGSM Cocaine FUEK6X COCAINE AND LODOCAINE G5W4WW Cafeine + Lidocaine + Procaine+ Cocaine GB3OEY Cocaine GBX7ZC Cocaine GFXM5C Cocaina GGUVGQ Cocaine GMGJSG Cocaine GOT2LZ cocaine GTTTTX COCAINE 5,1% + CAFFEINE + LIDOCAINE + PROCAINE H22O82 cocaine HFQF1Q cocain HKZ1VR Cocaine, Caffeine, Lidocaine. HPMMRG COCAINE HUA51A cocaine HV22C2 cocaine ICJJYI Cocaine ILI0KV cocaine INVI3H cocaine IO7IOO caffeine, lidocaine and cocaine IPDQJN Cocaine ISSSPG COCAINE

Code Identified Substances ITHPL9 cocaine IUPHSS Cocaine IWH4C5 Cocaine IWII3P Cocain JBOJJJ Cocaine JSAGFJ COCAINE JZAFXP Amphetamine KFXSJH cocaína KHBFT2 Cocaine KHMABJ cocaine LHLHFD Cocaine LZIOS8 Cocaine MHLLML Cocaine MMUMRC cocaine N8RGKU cocaine NANRGN COCAINE, PROCAINE, LIDOCAINE NSUV95 Cocaine NXTOSM cocaine NYXHZT COCAINE ODCD2V cocaine ODZFBN Cocaine OIXWB8 cocaine OWVZ9H COCAINE P5ABC7 COCAINE,CAFFEINE, LIDOCAINE, PROCAINE P659G5 cocaine, cafeine, lidocaine, procaine and lactose PVZFPA Cocaine, Procaine, Lidocaine and Caffeine Q772TV Cocaine Q8LGQQ Cocaine QCYBCZ Cocaine and Caffeine QHH5X6 cocaine QK1XXA cinnamonyl cocaine - procaine QMWQTQ Cocaine QRWM3W Cocaine QRXCOO Pseudococaine, Caffeine, Lidocaine QVHXRP COCAINE QYI8XO COCAINE QYYLCY Cocaine R2EIGV Cocaine RB8OK5 cocaine RHRRWR cocaine, caffeine, lidocaine, procaine RIJIJC COCAINE RJRT8O cocaine RNIHSP Cocaine RQJY2X cocaine, lidocaine, caffeine and procaine

Code Identified Substances RQQ9IG cocaine RRERCL cocaine RV1ATU Cocaine S6JCMD cocaine SEQGAQ cocaine SFILGT cocaine, lidocaine,procaine, caffeine SWTTQX Cocaine TEKB5H cocaine TFLCTJ cocaine TK1XDK Cocaine TMIOPH cocaine TNQR0R Cocaine TOTXN0 Cocaine TRJR2R Cocaine UJJUU1 COCAINE UJZXBO Cocaine UU0EDU cocain V0TJCT Cocaine V5A5C5 cocaine V7777W Cocaine V7UKSS cocaine VHRVSQ Cocaine hydrochloride VIBSI3 COCAINE VJEFF1 Cocaine VVRYSV Cocaine, Lidocaine, Procaine, Caffeine and Glucose VWKVJV cocaine VWVVHY Cocaine WATIXT chlorhydrate cocaine WH4B44 Cocaine WVV99T COCAINE X1WS11 cocaine XI5JGO Cocaine XIXNGM cocaine XKKPPR cocaine XNJQCT Cocaine XY5KFG ocaine Y6HBAA Cocaine, Lidocaine , Procaine YSMOUG Cocaine YSNVND Cocaine YZSZMS Cocaína Z9MTOM Cocaine ZCYZZA COCAINA ZO7E6M cocaine HCl

Statement of findings for Test Sample 1

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) 0B00MA + + - - Cocaine hcl, Caffeine, Creatine, purity 3,7+/-0,43 % (w/w)as base cocaine 0BPIQK + + + - It has been detected the presence of cocaine in the sample. 15KHZZ + + + + White powder containing cocaine. Also detected caffeine, procaine, lidocaine and cinnamoylcocaine. 1NBQEB + + + + After analyzing the sample with colorimetrics tests and confirmation with GC/MS methods and subsequent quantifcation with GC/FID, we confident that the sample contains 6.38% of cocaine base. Other substances: caffeine, lidocaine and procaine. 1OFS4X + + + + Sample contains 5.10 ± 0.20 % cocaine base. Caffeine, lidocaine, procaine and creatine were also detected. 1QHP1K ANP ANP ANP ANP

1X1W9X + + + + Sample contains 5.3% of cocain 20222K + + + + The sample contains 5.5% ± 3.6 % of Cocaine. Also contain Caffeine, Lidocaine and Procaine (trace amounts) 2C5GCK + + + + Presence of cocaine hydrochloride, caffeine, creatine, glucose was detected in the sample. 2JJEMT + + + + cocaine and adulterants usually found in cocaine seizures 2KHKFK + + + + we found cocaine, lidocaine, procaine and caffeine in the sample 333WNF + + + +

3I4END + + + + Caffeine, Lidocaine, Procaine

3XMCSS + + + + In the sample there are also glucose. 4IHDMJ + + + + Powder containing cocaine 4MQGMT + + + + also includes procaine, lidocaine and caffeine 4QDDDD + + + + Sample also include caffeine, creatine, lidocaine and procaine. 4WAP4I + + + - cocained existed in salt form. we were found caffeine and lidocaine in the sample 5B9R5Q - + + + Analysis detected the presence of cocaine with an approximate purity of 6% (as base). Lidocaine and procaine were also detected. 5D5Q5X + + + + The sample contains a controlled substance as cocaine and other substances besides cutting caffeine, procaine and lidocaine

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) 6HXWOM + + + + Caffeine, procaine and lidocaine are also detected.It is a sample of steet cocaine ( as is has common adulterants) with low concentration of cocaine 6I9L3N + + + + The sample contains cocaine, caffeine, lidocaine and procaine 6P0WWW + + + + Cocaine 5.29%, Caffeine, Lidocaine, Procaine and Glucose 6TZBOI + + + + The sample also contain creatine. 72SXT7 + + + + Test sample 2015/1/SM-1 contains cocaine base 5.59 %, m/m, procaine, caffeine, lidocaine and ceratinine. 7CVHQG + + + - Lidocaine,Caffeine, Creatinine and trace amount of Glucose 88CBR8 + + + + we have found cocaine, caffeine, lidocaine and procaine by using GC-MS. 8EKCQE + + + + also contains lidocaine, procaine and cafeine analyzed by GCMS and HPTLC 8P8J9S + + + + Sample contains cocaine hydrochloride (6.76% as base), caffeine, lidocaine, procaine and glucose. 8Z1D82 + + + - The sample SM1 was found to contain the controlled substance Cocaine. In addition it was found to contain Caffeine and Lidocaine. 999FTE + + + + procaine, caffeine, lidocaine, levamisole 9AQQ5Z + + + + By using LC-MS and LC-MS-MS , the sample contain Cocaine 5.2 % w/w, Caffiene, Procaine and Lidocaine. 9E9RV9 + + + + Cobalt thiocyanate (CT) positive, GC/MS retention time and mass charge ratio (M/Z) similar characteristics with the substances used as standard or pattern 9G1IGG + + + +

A55MTH + + + + We have not received LSD standard AFUPAX + + + - SM1 contains Cocaine HCl with 5.4 % Cocaine base. SM1 also contains Lidocaine, Caffeine, Creatinine, Glucose and trace amounts of Procaine AG4RDN + + + + This sample is cocaine. AGX9RJ + + + + Was found Caffeine, lidocaine and procaine. Cocaine Quantification results: 5.43 +-3.4 AM75RV + + + + SM-1 gives positive blue color to Cobalt Thiocyanate test. Identification with TLC and GCMS, SM-1 contains Cocaine, Lidocaine, Procaine and Caffeine. Quantitation with GC, SM-1 contains Cocaine base 5.25%, Caffeine 4.95%, Lidocaine 3.8% and Procaine 1.08%. ASAZSF + + + - Sample also contain caffeine, lidocaine

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) ATMMIK - + + + A sample of the powder was analysed and found to contain cocaine, which had a purity of 5%. This sample was also found to contain caffeine, lidocaine and procaine AXEI96 + + + + Cocaine, Lidocaine, Procaine and Caffeine detected in sample 2015/1/SM-1. Quantitative analysis not performed. BCQF5M + + + - SM-1 is positive for cocaine. BFDDDR ANP + - - The sample obtains with positive result with cobalt thiocyanate reagent. TLC: The Rf sample obtain with the same Rf Cocaine Standard. GC: The Rt sample obtain with the same Rt Cocaine Standard.

BUBXUF + + + - The results of the tests of SM1 (58) received confirmed that the mentioned sample contains cocaína with 6.9 percentage by weight (6.9%).The sample 1 contains also caffeín and lidocaíne as not controlled drugs. C0ZZJN + + + + Sample 2015/1/SM-1, a white, odourless powder, gave a positive result for cocaine, a controlled substance under national legislation on drugs. C77B7S + + + + Identified cocaine CLWMLL + + + - The powder contains 6% og cocaïne as free base, lidocaïne 4%, caféine 5% and glucose. Cocaïne is a controlled substance in France. CML6FN ANP + ANP ANP Quantity of white powder weighing 0.22grams analysed and confirmed to contain Cocaine. Procaine, Lignocaine and caffeine were indicated however not confirmed.Cocaine is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971. CRVCAC + + + +

CXZ7SL - + - +

DF8IPB + + + - - Primary screening revealed cocaïne - GC/MS alowed identification of cocaïne and cutting agents :(lidocaine and caffeine) DPMUDD + + + + Cocaine is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971. DSTAS1 + + + - COCAINE DXGEZT + + + + Cocaine is controlled by law (K.B. 31/12/1930, changed by K.B. 8/10/1963) EAEWNG + + + - found cocaine with 5.2%ww EGOAAA + + + + cocaine, lidocaine, procaine, caffeine EH8THK + + + + The sample contains cocaine. The content of cocaine (as cocainehydrochloride) is determined to 6 %. Cocaine is a controlled substance in Norway. EIUUUK + + + + The sample also contains caffeine, lidocaine, procaine and creatine-monohydrate.

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) EK1CYF + + + - sample found to contain cocaine, caffeine and lidocaine EKXNNH + + + + The sample contains Cocaine, Lidocaine, Procaine and Caffeine. ERGL66 + + + + Powder was found to contain cocaine. purity was determined to be 5% calculated as base. FG6OYO + + + + the sample contains cocaine (scheduled as illicit drug in France), caffeine, lidocaine, procaine, creatine, glucose, mannitol FSLFBU + + + + The white powder was analysed and found to contain cocaine. FSOGSM + + + - Test sample 2015/1/SM-1 contains cocaine, a dangerous drug. It also contains caffeine and lidocaine. FUEK6X + + + - THE SAMPLE SM-1 WAS ANALYSED AND FOUND TO TO CONTAIN COCAINE AND LIDOCAINE

G5W4WW + + + + For sample 2015/1/SM-1 was first a preliminary test to determine the presence of what kind of drugs we have used two Scott reagent tests (tyocianato of Cobalte) and the Marquis reagent. After a TLC and to that end we used a 20 × 20, silica as a solvent dichloromethane was used and how the Methanol eluent. Finally there was a gas chromatography using flame Ionization Detector (GC- FID), in the preparation of the samples used as solvent, chloroform/ethanol mixture and tetracosano (internal standard), and the column TRACSIL TRB-50 (50%) Diphenyl-(50%) dimethyl polysiloxane, Flow Rate of 1.5 ml/min and Pressure of 14.7 psi. GB3OEY + + + - One glass bottle containing 0.23 grammes of a powder containing 0.01 grammes of cocaine. GBX7ZC ANP + ANP ANP

GFXM5C + + + - The chemical tests and the coincidence in the time of retention and mass fragmentogram with the material of reference used in the same conditions that the analyzed sample, indicate in this one the cocaine presence. GGUVGQ + + - +

GMGJSG + + + + cocaine+Procaine+Lidocaine+Cafine GOT2LZ + + + + COCAINE 5.9% AS BASE, caffeine, lidocaine and procaine GTTTTX + + + +

H22O82 + + + - The sample contained 5.1% w/w Cocaine. Substances detected include Caffeine and Lidocaine. HFQF1Q + + + - lidocain 4.8 %, caffein 5.08%, parcetamol 1.4 % HKZ1VR + + + - The Sample ICE2015/1/SM1 was found to contain Cocaine, Caffeine and Lidocaine. HPMMRG + + + - LIDOCAINE AND CAFEINE

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) HUA51A + + + - cocaine, caffeine, lidocaine HV22C2 + + + + cocaine(5%), cafeine, procaine (1%),lidocaine(4%) ICJJYI + + + - quantification results: 5,1% +/- 0,5 ILI0KV + + + - cocaine was detected by GC/MS screening and it was quantified by GC/FID using calibration curve INVI3H + + + - a substance is related to drug - cocaine IO7IOO + + + ANP the sample SM1 contains caffeine, lidocaine and cocaine IPDQJN + + + - Cocaine ISSSPG + + + - COCAINE-LIDOCAINE Y CAFFEINE ITHPL9 + - + + contained glucose, caffeine, lidocaine, procaine IUPHSS + + + - The sample contains cocaine IWH4C5 + + + + Lidocaine, Procaine, Caffeine IWII3P + + + + 6.5% JBOJJJ + + + + The sample contains cocaine (5.6%), lidocaine, caffeine and procaine. JMMMUB + + + -

JSAGFJ - + - - Field Test was performed employing Cobalt Thiocynate test gave a positive result for the presence of Cocaine. JZAFXP - - - - Sample no1 contains stimulant (Amphetamine) KFXSJH + + + + pruebas cromáticas, marquis, Scott instrumentales: GC-MS, ESPECTROMETRIA UV KHBFT2 ANP + ANP ANP Contains Cocaine. KHMABJ + + + - The sample contains cocaine, creatine, caffeine and lidocaine. LHLHFD + + + + Cocaine, Lidocaine, Procaine and Caffeine LZIOS8 + + + + The percentage of cocaine is 6.1 % MHLLML + + + + Usual substance and adulterants. MMUMRC + + + + contained caffeine, lidocaine, procaine, methylecgonidine,glucose,creatinine

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) N8RGKU + + + + Sample 2015/1/SM-1 consists of white powder. Cocaine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. NANRGN + + + + In the sample are caffeine, levamisole and other cinnamoleocaina such as cis-, and trans-cinnamo leocaine NSUV95 + + + + The exhibit were found to contain Cocaine, Methyl Ester Ecgonidine, Lidocaine, Procaine and Caffeine. NXTOSM + + + ANP

NYXHZT + + + + PROCAINE, LIDOCAINE, CAFFEINE ODCD2V + + + + Cocaine, caffeine, lidocaine, procaine, phenyltetrahydroimidathiazole, creatine, and dextrose confirmed in 1 unit tested of 1 unit received. ODZFBN + + + + The sample contains cocaine, caffeine, procaine, lidocaine and creatine. OIXWB8 + + + + cocaine 5.8%ww, caffeine, lidocaine, procaine, glucose OWVZ9H + + - + White powder that contains controlled substance COCAINE. P5ABC7 + + + + WHITE POWDER SAMPLE ANALYZED CONTAINS : COCAINE,CAFFEINE, LIDOCAINE, PROCAINE. P659G5 + + + +

PVZFPA + + + + Examination revealed the presence of Cocaine, Procaine and Lidocaine Q772TV + + + - Caffeine and Lidocaine Q8LGQQ + + + + *Results of screening tests were positive for cocaine. *Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with cocaine, lidocaine, procaine and caffeine. QCYBCZ + + - - Caffeine is not included in UN notified precursor chemicals. But in our country, Myanmar, we notified it as precursor chemical. QHH5X6 + + + + white powder containing caffeine and cocaine QK1XXA + + + -

QMWQTQ + + + + Cocaine was identified in the sample and also Caffeine, Lidocaine and Procaine were identified.Further analysis revealed that the percentage of cocaine is 36.3. QRWM3W + + + + Caffeine, Lidocine and procaine QRXCOO + + + - Blue color appear with Cobalt Thiocyanate test and blue color reappear in the lower chloroform layer by modified Cobalt Thiocyanate test which indicates possible presence of Cocaine.Purple color with Amalic Acid test indicates possible presence of caffeine. Analysis by GCMS show the similarity as pseudococaine, caffeine and lidocaine. 17 2015/1-SM Copyright (c) 2015 UNODC INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) QVHXRP + + + + CREATINE, CAFFEINE AND OTHER COCA PRODUCTS WERE IDENTIFIED QYI8XO + + + + The sample contains ; Cocaine , Lidocaine, Caffeine and Procaine QYYLCY + + + + the sample contains cocaine,caféine, lidocaine,et procaine. Cocaine is scheduled as illicit drug. R2EIGV + + + + In the test sample 2015/1/SM-1 were detected cocaine, caffeine, lidocaine and procaine RB8OK5 + + + - No determinado con creatina monohidrato, lidocaina y cafeina RHRRWR + + + + The sample was found to contain cocaine, lidocaine, procaine and caffeine. RIJIJC + + + - the powder is a mixture of cocaine hydrochloride, glucose, creatine hydrate, caffeine and lidocaine. The concentration of cocaine, as free base, in the sample is 6.5% by weight. RJRT8O + + + + Cocaine was as hydrochloride form RNIHSP + + + +

RQJY2X + + + + In the sample labeled as 2015/1 / SM-1 was found cocaine, procaine, lidocaine and caffeine. RQQ9IG + + + ANP after chemical analysis was performed the sample contain . 1- cocaine 7.55% 2- caffeine 3- lidocaine

RRERCL + + + +

RV1ATU + + + + Presence of caffeine, lidocaine and procaine. FTIR analysis detected the presence of creatine. S6JCMD + + + + The sample was found to contain 5.3% of cocaine (as base). The sample was also found to contain caffeine, lidocaine, procaine, fructose and glucose. SEQGAQ - + - - sample contained cocaine HCl as a controlled drug SFILGT + + + +

SWTTQX + + - - Cocaine and caffeine are detected. TEKB5H + + + - the white powder contains cocaine (5.2%ww) which is controlled by national laws. In addition caffeine and lidocaine have been found in the sample. TFLCTJ + + + +

TK1XDK - + + - The sample found to contain Cocaine TMIOPH + + + - The sample contain cocaine, caffeine, lidocaine and creatine.

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) TNQR0R + + + + contained cocaine, lidocaine, cofeine, procaine, creatinine and trace of methylecgonidine, cinnamoilcocaine. cis-cinnamoilcocaine

TOTXN0 + + + + The sample contains cocaine, lidocaine, procaine and caffeine. TRJR2R + + + + caffeine creatine lidocaine procaine UJJUU1 + + + - Cocaine is a Class A controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). UJZXBO + + + + The test sample 2015/1/SM-1 was found to contain the controlled drug cocaine. The sample was also found to contain caffeine, lidocaine and procaine. UU0EDU + + + + adulterant/diluents: caffeine, creatine, prokain, lidokain V0TJCT + + + +

V5A5C5 + + + + the sample is mxture of cocaine with lidocaine, procaine, caffeine and creatinine V7777W + + + + The powder was found to contain 5% cocaine; caffeine, lignocaine and procaine were also detected. Cocaine is controlled by the Misuse of Drugs Act (as amended) as a Class A drug. Caffeine, lignocaine and procaine are not controlled by the Misuse of Drugs Act 1971 (as amended). V7UKSS + + + - Narcotics: cocaine, approximately 6 % as free base VHRVSQ + + + + Item 2015/1/SM-1 contained Cocaine hydrochloride, at a purity of six per cent. VIBSI3 + + + -

VJEFF1 - + + - The sample contains cocaine which is listed as a controlled drug according to french order, appendix I of February 22nd 1990. VVRYSV + + + + The Test sample 2015/1/SM-1 was analyzed by colour test and Thin Layer Chromatography technique and found to contain Cocaine, Lidocaine, Procaine, Caffeine and Glucose. VWKVJV + + + +

VWVVHY + + + +

WATIXT + + + + chlorhydrate cocaïne is present (6.3% w/w as base) with caffeine lidocaine procaïne creatine and glucose. WH4B44 ANP + ANP ANP - WVV99T + + + + White powder containing Cocaine (List I CU 1961) 5.63% and other substances as adulterants: Caffeine, Lidocaine and Procaine

Lidocaine Code Caffeine Cocaine Procaine (Lignocaine) X1WS11 ANP + ANP ANP

XI5JGO + + + -

XIXNGM + + + + ./. XKKPPR + + + + white powder, other compounds - caffeine, lidocaine and procaine XNJQCT + + + + The sample contained cocaine with lidocaine, procaine and caffeine. XODXXJ + + + +

XRRKRK + + + +

XY5KFG ANP + ANP + There was evidence that the test sample 2015/1/SM-1 contained cocaine Y6HBAA + + + + The sample contains Cocaine Hydrochloride (8.2% as base) with Lidocaine, Procaine and Caffeine. YN88GB - - ANP ANP No se detectó YSMOUG + + + + Based on the above analysis, the sample was found to contain cocaine, lidocaine, procaine, caffeine and levamisole. YSNVND + + + + We found cocaine as controlled drug and also lidocaine, procaine, and caffeine as adulterants YZSZMS + + + - La muestra contiene además cafeína y lidocaína Z9MTOM + + + + caffeine, lidocaine, procaine, glucose and creatine ZCYZZA + + + + CAFEINA - LIDOCAINA - PROCAINA ZO7E6M + + + + additional substances: creatine, lidocaine, procaine, caffeine

Identification methods for Test Sample 1

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Analytical Technique Codes Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 0B00MA S S S I I I XRD 0BPIQK SI I 15KHZZ S I I SI 1NBQEB SI SI S I I 1OFS4X S SI I SI SI 1X1W9X SI 20222K S I I 2C5GCK SI I I I 2JJEMT SI I 2KHKFK I SI I 333WNF S S S I I 3I4END I SI 3XMCSS SI I 4IHDMJ SI 4MQGMT SI SI 4QDDDD S I I I 4WAP4I S I I I 5B9R5Q S S S I I 5D5Q5X S I SI 6HXWOM I I SI I 6I9L3N S S S I S 6P0WWW S I 6TZBOI S SI SI I 72SXT7 I SI 7CVHQG S I I 88CBR8 SI 8EKCQE SI SI I I 8P8J9S S S I 8Z1D82 I S 999FTE SI 9AQQ5Z SI I 9E9RV9 S S S I 9G1IGG SI I A55MTH I

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 AFUPAX I S I I AG4RDN S I I AGX9RJ S S S I I AM75RV S S S I I ASAZSF SI ASAP-TOF ATMMIK S S I S Miscroscopy AXEI96 S SI BCQF5M S I BFDDDR S S S I BUBXUF S S S I I C0ZZJN S S S I C77B7S S S S SI CLWMLL I I I S I GC MS + Derivatization CML6FN S I CRVCAC I SI SI CXZ7SL S I DF8IPB S I I DPMUDD S S S I DSTAS1 SI I DXGEZT S I S EAEWNG SI EGOAAA SI EH8THK I I EIUUUK S SI SI I EK1CYF S I I I EKXNNH S S S I SI I ERGL66 I I FG6OYO S I I I FSLFBU S I I FSOGSM S S S I I I Chen Kao Reagent FUEK6X S S I I G5W4W S S S I I W GB3OEY S S SI GBX7ZC I GFXM5C S S S I GGUVGQ SI GMGJSG I S ION-SCAN GOT2LZ S S S I GTTTTX S S S SI I I

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 H22O82 S S S I I I HFQF1Q SI HKZ1VR S S S I I HPMMRG I SI HUA51A S S S SI I SI HV22C2 S I I ICJJYI S I ILI0KV SI INVI3H SI IO7IOO S S S I S Tanred IPDQJN I SI SI ISSSPG S S S I I ITHPL9 SI IUPHSS I SI I IWH4C5 SI I IWII3P SI JBOJJJ S S S I I JMMMUB S S SI I I I JSAGFJ S S S I I I S TEST STRIPS JZAFXP I SI SI immunoassay KFXSJH S S SI I I KHBFT2 S S S I I KHMABJ S S SI SI I LHLHFD SI SI I LZIOS8 S S S I I SI S I Tollens reag. MHLLML S I I I SI FEHLING MMUMRC SI N8RGKU S S I I I NANRGN S S I I I cloruro de mercurio NSUV95 I I S NXTOSM S S S I NYXHZT S S S SI I ODCD2V I SI I ODZFBN I I OIXWB8 I I SI OWVZ9H S S I I P5ABC7 S S I P659G5 S S I I PVZFPA S SI

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 Q772TV S I Q8LGQQ S S S I I QCYBCZ I I SI QHH5X6 SI QK1XXA S S S SI SI I I QMWQT I S S I I I I I fast blue B Q QRWM3 I SI W QRXCOO S S S I SI Amalic Acid test QVHXRP I SI I QYI8XO S I I QYYLCY I SI I R2EIGV I RB8OK5 S I I RHRRWR S I RIJIJC I I I SI I SI XRD RJRT8O SI RNIHSP S S I I RQJY2X S S I RQQ9IG S S I RRERCL S S S I I RV1ATU I I I SI S6JCMD SI I ELSD SEQGAQ S S I I S n.a. SFILGT I SI I SWTTQX S S I TEKB5H I I SI TFLCTJ I SI TK1XDK S S I TMIOPH S SI I SI I TNQR0R SI TOTXN0 SI TRJR2R SI SI UJJUU1 S S I I S PIPERAZINES UJZXBO S S S I I UU0EDU I SI SI V0TJCT S I I V5A5C5 S S SI I I I I V7777W S S I

Code 140 141 142 150 160 161 170 171 180 190 200 211 230 231 210 V7UKSS I SI I VHRVSQ S I I VIBSI3 SI S VJEFF1 I I VVRYSV S S I S Fast Blue B Salt Test VWKVJV SI VWVVHY S I WATIXT I I WH4B44 SI WVV99T S S S I SI X1WS11 SI SI SI I XI5JGO S S SI XIXNGM I SI SI XKKPPR SI I XNJQCT SI XODXXJ SI I XRRKRK S S I S Duquenois levin XY5KFG SI I Y6HBAA SI S S I I YN88GB S S I I YSMOUG S I S Simon reagent YSNVND S S SI I S Duquinoise YZSZMS S S S I I Z9MTOM S I I ZCYZZA S I I ZO7E6M SI I XRD

Summary for test sample 1 The response summary of all 177 participating laboratories for the identification of SM-1, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 1: Response Summary Participants: 177

Caffeine: 160 Cocaine: 173 Lidocaine (Lignocaine): 159 Procaine: 116

False positives for Test Sample 1

Code Name Technique ITHPL9 C annabidiol 180 JZAFXP Amfetamine 161/180

False negatives for SM-1 (techinque(s) used or ANP)

Code: ITHPL (180), JZAFXP (161/180), YN88GB (150), IQHPIK (ANP)

Frequency of use of screening and identification techniques: Response Summary Response Summary Participants:Response Summary 130 Participants:Participants: 177171 142 150 160 161 190 200 220 SectionSection 140140141 141142 142150 150160 160161 161170 170171 171180 180190 190200 200211 211230 231231 210 210 Screening 67 72 62 20 0 2 1 3 71 11 3 0 1 1 15 37.9% 40.7% 35.0% 11.3% 0.0% 1.1% 0.6% 1.7% 40.1% 6.2% 1.7% 0.0% 0.6% 0.6% 8.5% Identification 9 3 2 44 12 19 2 29 159 60 5 2 1 4 13 5.1% 1.7% 1.1% 24.9% 6.8% 10.7% 1.1% 16.4% 89.8% 33.9% 2.8% 1.1% 0.6% 2.3% 7.3% # labs using 73 72 62 51 12 19 2 30 160 63 8 2 1 4 23 this technique 41.2% 40.7% 35.0% 28.8% 6.8% 10.7% 1.1% 16.9% 90.4% 35.6% 4.5% 1.1% 0.6% 2.3% 13.0% 26

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 1 Cocaine Cocaine Deviation Code Concentration Deviation from Code Concentration z-score from robust z-score (mass%) robust average (mass%) average BFDDDR 1.45 4.0 -8.4 DPMUDD 5.30 0.1 -0.3 GGUVGQ 2.70 2.7 -5.8 QYYLCY 5.30 0.1 -0.3 0B00MA 3.70 1.7 -3.7 S6JCMD 5.30 0.1 -0.3 JSAGFJ 4.04 1.4 -3.0 TNQR0R 5.30 0.1 -0.3 VIBSI3 4.20 1.2 -2.6 VJEFF1 5.30 0.1 -0.3 9G1IGG 4.40 1.0 -2.2 XODXXJ 5.34 0.1 -0.2 HUA51A 4.50 0.9 -2.0 QRXCOO 5.37 0.0 -0.2 GB3OEY 4.60 0.8 -1.8 QRWM3W 5.38 0.0 -0.2 ODCD2V 4.70 0.7 -1.6 4IHDMJ 5.40 0.0 -0.1 DSTAS1 4.70 0.7 -1.6 AFUPAX 5.40 0.0 -0.1 RJRT8O 4.80 0.6 -1.4 NXTOSM 5.40 0.0 -0.1 WH4B44 4.85 0.6 -1.3 ODZFBN 5.40 0.0 -0.1 88CBR8 4.86 0.5 -1.3 R2EIGV 5.40 0.0 -0.1 3XMCSS 4.90 0.5 -1.2 VWVVHY 5.40 0.0 -0.1 2KHKFK 5.00 0.4 -1.0 XIXNGM 5.40 0.0 -0.1 CML6FN 5.00 0.4 -1.0 XKKPPR 5.40 0.0 -0.1 ERGL66 5.00 0.4 -1.0 AGX9RJ 5.43 0.0 -0.1 FG6OYO 5.00 0.4 -1.0 4QDDDD 5.45 0.0 0.0 HV22C2 5.00 0.4 -1.0 V7UKSS 5.45 0.0 0.0 TRJR2R 5.00 0.4 -1.0 ATMMIK 5.46 0.1 0.0 UJJUU1 5.00 0.4 -1.0 QHH5X6 5.46 0.1 0.0 V7777W 5.00 0.4 -1.0 20222K 5.50 0.1 0.1 X1WS11 5.09 0.3 -0.8 4WAP4I 5.50 0.1 0.1 1OFS4X 5.10 0.3 -0.8 5B9R5Q 5.50 0.1 0.1 4MQGMT 5.10 0.3 -0.8 ISSSPG 5.50 0.1 0.1 8Z1D82 5.10 0.3 -0.8 IWH4C5 5.50 0.1 0.1 GFXM5C 5.10 0.3 -0.8 RB8OK5 5.50 0.1 0.1 GTTTTX 5.10 0.3 -0.8 IUPHSS 5.56 0.2 0.2 H22O82 5.10 0.3 -0.8 MHLLML 5.58 0.2 0.3 ICJJYI 5.10 0.3 -0.8 72SXT7 5.59 0.2 0.3 MMUMRC 5.10 0.3 -0.8 999FTE 5.59 0.2 0.3 Q8LGQQ 5.10 0.3 -0.8 IO7IOO 5.60 0.2 0.3 RV1ATU 5.10 0.3 -0.8 JBOJJJ 5.60 0.2 0.3 Z9MTOM 5.10 0.3 -0.8 TOTXN0 5.60 0.2 0.3 RV1ATU 5.10 0.3 -0.7 CRVCAC 5.62 0.2 0.3 A55MTH 5.15 0.3 -0.6 HFQF1Q 5.63 0.2 0.4 P659G5 5.19 0.2 -0.6 WVV99T 5.63 0.2 0.4 9AQQ5Z 5.20 0.2 -0.5 2C5GCK 5.70 0.3 0.5 EAEWNG 5.20 0.2 -0.5 DXGEZT 5.70 0.3 0.5 EH8THK 5.20 0.2 -0.5 AG4RDN 5.72 0.3 0.6 TEKB5H 5.20 0.2 -0.5 6HXWOM 5.80 0.4 0.7 VWKVJV 5.20 0.2 -0.5 EKXNNH 5.80 0.4 0.7 3I4END 5.23 0.2 -0.5 KHMABJ 5.80 0.4 0.7 QVHXRP 5.24 0.2 -0.5 OIXWB8 5.80 0.4 0.7 AM75RV 5.25 0.2 -0.4 YZSZMS 5.80 0.4 0.7 333WNF 5.28 0.1 -0.4 ITHPL9 5.81 0.4 0.7 IPDQJN 5.28 0.1 -0.4 NYXHZT 5.83 0.4 0.8 6P0WWW 5.29 0.1 -0.4 GOT2LZ 5.90 0.5 0.9 RRERCL 5.29 0.1 -0.4 1X1W9X 5.30 0.1 -0.3 6I9L3N 5.30 0.1 -0.3 27 2015/1-SM Copyright (c) 2015 UNODC INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Cocaine Deviation Code Concentration from robust z-score (mass%) average 7CVHQG 6.00 0.6 1.1 8EKCQE 6.00 0.6 1.1 CLWMLL 6.00 0.6 1.1 VHRVSQ 6.00 0.6 1.1 LZIOS8 6.10 0.7 1.4 Q772TV 6.10 0.7 1.4 ILI0KV 6.27 0.9 1.7 C77B7S 6.30 0.9 1.8 WATIXT 6.30 0.9 1.8 ZO7E6M 6.30 0.9 1.8 1NBQEB 6.40 1.0 1.9 IWII3P 6.50 1.1 2.2 RIJIJC 6.50 1.1 2.2 XI5JGO 6.70 1.3 2.6 8P8J9S 6.76 1.4 2.7 BUBXUF 6.90 1.5 3.0 0BPIQK 7.00 1.6 3.3 RQQ9IG 7.55 2.2 4.4 V5A5C5 7.56 2.2 4.4 5D5Q5X 7.90 2.5 5.1 DF8IPB 7.98 2.6 5.3 Y6HBAA 8.20 2.8 5.8 TFLCTJ 9.85 4.5 9.3 KFXSJH 11.30 5.9 12.3 BCQF5M 13.42 8.0 16.8 FUEK6X 14.96 9.6 20.0 INVI3H 35.65 30.3 63.6 QMWQTQ 36.30 30.9 65.0

Round: 2015/1 Robust average = 5.4% UNODC value = 5.2% Substance: SM-1; Cocaine

4.0 3.3 3.0 3.0 2.7 2.6 2.2 2.2

2.0 1.9 1.8 1.8 1.8 1.7 1.4 1.4 1.1 1.1 1.1 1.1

1.0 0.9 0.8 0.7 0.7 0.7 0.7 0.7 0.7 0.6 0.5 0.5 0.4 0.4 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.2 0.1 0.1 0.1 0.1 0.1 0.1 8.4 0.0 0.0 ‐ 0.0 4.4 5.1 5.8 12.3 20 65 5.3 9.3 16.8 63.6 0.0 0.0 4.4 0.1 ‐ 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ 0.2 0.2 ‐ ‐ 3 0.2 ‐ 0.3 0.3 0.3 0. 0.3 0.3 0.3 0.4 0.4 ‐ ‐ ‐ ‐ ‐ ‐ ‐ 0.4 0.4 ‐ ‐ ‐ ‐ 0.4 0.5 ‐ 0.5 ‐ ‐ 0.5 0.5 0.5 0.5 0.5 ‐ 0.6 ‐ ‐ ‐ ‐ ‐ 0.6 ‐ 0.7 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 ‐ 0.8 ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐

‐1.0 ‐ 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ 1.2 ‐ 1.3 1.3 ‐ ‐ 1.4 ‐ 1.6 1.6 ‐ ‐

‐2.0 1.8 ‐ 2.0 ‐ 2.2 ‐ 2.6 ‐3.0 ‐ 3.0 ‐ 3.7 ‐4.0 ‐ ICJJYI RIJIJC JBOJJJ ILI0KV 772TV VIBSI3 IWII3P TFLCTJ ISSSPG LZIOS8 JSAGFJ VJEFF1 ITHPL9 6I9L3N 8P8J9S INVI3H XI5JGO DF8IPB KFXSJH IUPHSS 999FTE TRJR2R R2EIGV 72SXT7 IO7IOO 0BPIQK 3I4END IPDQJN RRERCL 20222K UJJUU1 RJRT8O C77B7S QYYLCY AGX9RJ GTTTTX ERGL66 1OFS4X 8Z1D82 DSTAS1 XODXXJ V7UKSS XKKPPR 2KHKFK 9G1IGG 88CBR8 FUEK6X TEKB5H 4IHDMJ P659G5 GOT2LZ YZSZMS 8EKCQE DXGEZT WATIXT V5A5C5 NYXHZT HV22C2 2C5GCK EH8THK Q 4WAP4I S6JCMD RB8OK5 AFUPAX 5B9R5Q CRVCAC RQQ9IG RV1ATU H22O82 TOTXN0 GB3OEY RV1ATU IWH4C5 3XMCSS 5D5Q5X Y6HBAA BUBXUF X1WS11 OIXWB8 BFDDDR 9AQQ5Z TNQR0R ODZFBN CML6FN FG6OYO HFQF1Q 1NBQEB QVHXRP XIXNGM VWKVJV KHMABJ EKXNNH VHRVSQ HUA51A 1X1W9X QHH5X6 V7777W GFXM5C ODCD2V ZO7E6M 0B00MA 333WNF AG4RDN 7CVHQG WVV99T AM75RV ATMMIK A55MTH CLWMLL QRXCOO Q8LGQQ WH4B44 BCQF5M MHLLML NXTOSM 4QDDDD VWVVHY EAEWNG GGUVGQ Z9MTOM DPMUDD 4MQGMT 6HXWOM 6P0WWW QMWQTQ MMUMRC QRWM3W

z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43- 1:1997(E) as follows: |z| < 2 = satisfactory 2 ≤ |z| ≤ 3 = questionable |z| > 3 = unsatisfactory

Z-Score Report per Sample per Substance

Round: 2015/1

Dispersion of z-scores using different analytical techniques for the quantification of cocaine in 2015/1 SM-1 10.0

8.0

6.0

4.0

2.0

0.0 z-score

-2.0

-4.0

-6.0

-8.0 HPLC GC-FID GC/MS -10.0

30 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Sample 2 Analysis

Identified substances for Test Sample 2

Code Identified Substances 0B00MA AMPHETAMINE 0BPIQK amphetamine 15KHZZ Amphetamine 1NBQEB amphetamine 1OFS4X Amfetamine 1X1W9X Amphetamine 20222K Amfetamine 2C5GCK Amphetamine 2JJEMT amphetamine, caffeine 2KHKFK Amphetamine 333WNF Amphetamine, Caffeine 3I4END Amphetamine 3XMCSS AMPHETAMINE 4IHDMJ amphetamine 4MQGMT amphetamine 4QDDDD amphetamine sulphate 4WAP4I amfetamine 5B9R5Q Amphetamine 5D5Q5X AMPHETAMINE 6HXWOM Amphetamine 6I9L3N anfetamine 6P0WWW Amphetamine and Caffeine 6TZBOI amphetamine 72SXT7 Amphetamine 7CVHQG Amfetamin 88CBR8 amfetamine 8EKCQE amfetamine 8P8J9S Amphetamine 8Z1D82 Amphetamine 999FTE amphetamine 9AQQ5Z Amphtamine 9E9RV9 Caffeine 9G1IGG amphetamine AFUPAX Amfetamine Sulphate AG4RDN Amphetamine AGX9RJ amphetamine AM75RV Amphetamine and Caffeine ASAZSF Amphetamine ATMMIK Amphetamine AXEI96 Amphetamine and Caffeine

Code Identified Substances BCQF5M Amphetamine BFDDDR Amphetamine BUBXUF AMPHETAMINE C0ZZJN AMPHETAMINE C77B7S Amphetamine CLWMLL Amfétamine CML6FN Amphetamine CRVCAC amfetamine,caffeine DF8IPB Amphetamine DPMUDD Amfetamine, purity 5% DSTAS1 AMFETAMINE DXGEZT Amfetamine EAEWNG amfetamine EGOAAA amphetamines EH8THK Amphetamine EIUUUK amfetamine EK1CYF Amphetamine EKXNNH Amfetamine ERGL66 Amphetamine, caffeine FG6OYO amphetamine FSLFBU Amphetamine FSOGSM Amphetamine G5W4WW Methanphetamine + Cafeine GB3OEY Amphetamine GBX7ZC Anphetamine GFXM5C Amfetamine GGUVGQ Amphetamine GMGJSG Amfetamine GOT2LZ amphetamine GTTTTX ANFETAMINE 5,9 % + CAFFEINE H22O82 Amphetamine HFQF1Q amfetamin HKZ1VR Amphetamine, Caffeine. HPMMRG AMPHETAMINE HUA51A amfetamine HV22C2 amphetamine ICJJYI amphetamine ILI0KV amfetamine IO7IOO amphetamine and caffeine IPDQJN Amphetamine ISSSPG AMFETAMINE ITHPL9 amfetamine IUPHSS Amphetamine IWH4C5 Amphetamine

Code Identified Substances IWII3P Amphetamine JBOJJJ Amfetamine JSAGFJ Amphetamine and Paracetamol JZAFXP cocaine, lidocaine, procaine, caffeine KFXSJH ANFETAMINA KHBFT2 Amphetamine KHMABJ amphetamine LHLHFD Amfetamine LZIOS8 Amfetamine MHLLML Amphetamine MMUMRC amfetamine N8RGKU amfetamine NANRGN amphetamine NXTOSM amfetamine NYXHZT AMFETAMINE ODCD2V d,l amphetamine ODZFBN Amphetamine OIXWB8 d-l-amfetamine OWVZ9H AMPHETAMINE P5ABC7 AMPHETAMINE, CAFFEINE P659G5 amphetamine and cafeine PVZFPA Amphetamine and Caffeine Q772TV Amphetamine Q8LGQQ Amfetamine QCYBCZ Caffeine QHH5X6 amfetamine QK1XXA n- benzyl -2 methyl aziridin QRWM3W Amfetamine QRXCOO Amfetamine, Caffeine QVHXRP AMFETAMINE QYI8XO Amfetamine QYYLCY Amphetamine R2EIGV Amfetamine RB8OK5 amfetamine RHRRWR amphetamine, caffeine RIJIJC amfetamine RJRT8O amfetamine RNIHSP Amphetamine RQJY2X caffeine and amphetamine RQQ9IG amphetamine RRERCL amphetamine RV1ATU Amphetamine S6JCMD amphetemine SEQGAQ amfetamine

Code Identified Substances SFILGT amphetamine, caffeine SWTTQX Alpha Methyl Benzeneethanamine and caffeine are detected. TEKB5H amfetamine TFLCTJ amfetamine TK1XDK Amphetamine TMIOPH amphetamine TNQR0R Amfetamine TOTXN0 Amfetamine TRJR2R amfetamine UJJUU1 AMPHETAMINE UJZXBO Amphetamine UU0EDU amphetamine V0TJCT Amfetamine V5A5C5 amphetamine V7777W Amphetamine V7UKSS amphetamine VHRVSQ Amphetamine VIBSI3 amfetamine VJEFF1 Amfetamine VVRYSV Caffeine VWKVJV sulfat amphetamine VWVVHY Amphetamine WATIXT sulphate amfetamine WH4B44 Amfetamine WVV99T Amfetamine X1WS11 anfetamine XI5JGO Amphetamine XIXNGM AMFETAMINE XKKPPR amphetamine XNJQCT Amphetamine XY5KFG Mescaline Y6HBAA Amphetamine YN88GB Cafeína YSMOUG Amphetamine YSNVND Amphetamine YZSZMS Amfetamina Z9MTOM amfetamine ZCYZZA ANFETAMINA ZO7E6M amphetamine sulphate

Statement of findings for Test Sample 2

Code Amfetamine Caffeine 0B00MA + + Amphetamine sulphate, Caffeine, Creatine purity 6,4% as base amphetamine 0BPIQK + + It has been detected the presence of amphetamine in the sample. 15KHZZ + + White powder containing amphetamine. Also detected caffeine. 1NBQEB + + After analyzing the sample with colorimetrics tests and confirmation with GC/MS methods and subsequent quantifcation with GC/FID, we confident that the sample contains 5.01% of amphetamine base. Other substances: caffeine. 1OFS4X + + Sample contains 5.55 ± 0.43 % amfetamine base. Caffeine and creatine were also detected. 1QHP1K ANP ANP

1X1W9X + + Sample contains 5.6 % of amphetamine 20222K + + Also contain Caffeine 2C5GCK + + Presence of amphetamine sulphate, caffeine, creatine was detected in the sample. 2JJEMT + +

2KHKFK + + we found amphetamine and caffeine in the sample 333WNF + +

3I4END + + Caffeine 3XMCSS + +

4IHDMJ + + Powder containing amphetamine 4MQGMT + + also includes caffeine 4QDDDD + + Sample also include caffeine, creatine. 4WAP4I + + we were found caffeine in the sample 5B9R5Q + + Analysis detected the presence of amphetamine with an approximate purity of 24% (as base). Caffeine was also detected. 5D5Q5X + + The sample contains a controlled substance as well as substance amphetamine and caffeine cutting 6HXWOM + + Caffeine is also detected. It is a sample of street amphetamine with low concentration of amphetamine

Code Amfetamine Caffeine 6I9L3N + + The sample contains anfetamine and caffeine 6P0WWW + + Amphetamine 4,89% and Caffeine 6TZBOI + + The sample also contain creatine. 72SXT7 + + Test sample 2015/1/SM-2 contains amphetamine base 5.52 %, m/m, caffeine and ceratinine. 7CVHQG + + Caffeine and Creatinine 88CBR8 + + We have found amfetamine and caffeine by using GC-MS. 8EKCQE + + also contains cafeine analyzed by GCMS 8P8J9S + + Sample contains Amphetamine Sulfate and caffeine. Amphetamine is below the level of quantification for our laboratory (<0.04%). Quantitative analysis was performed by GC-FID. 8Z1D82 + + The sample SM2 was found to contain the controlled substance Amphetamine. In addition it was found to contain Caffeine. 999FTE + + caffeine 9AQQ5Z + + By using LC-MS and LC-MS-MS , the sample contain Amphetamine 5.3 % w/w and Caffiene. 9E9RV9 - + Cobalt thiocyanate (CT) negative, GC/MS retention time and mass charge ratio (M/Z) similar characteristics with the substances used as standard or pattern 9G1IGG + +

A55MTH - +

AFUPAX + + SM2 contains Amfetamine Sulphate with 6.22 % Amfetamine base. SM2 also contains Caffeine and Creatinine AG4RDN + + This sample is amphetamine. AGX9RJ + + was found caffeine AM75RV + + SM-2 gives positive to Marquis' and Simon's test. Identification with TLC and GCMS, SM-2 contains Amphetamine and Caffeine. Quantitation with GC, SM-2 contains Amphetamine base 5.74% and Caffeine 28.59%. ASAZSF + + Sample also contain caffeine ATMMIK + + A sample of this powder was analysed and found to contain amphetamine at purity of 4%. This sample was also found to contain caffeine. AXEI96 + + Amphetamine and Caffeine detected in sample 2015/1/SM-2. Quantitative analysis not performed. BCQF5M + + SM-2 is positive for amphetamine.

Code Amfetamine Caffeine BFDDDR + ANP The sample obtains with positive result with Marquis reagent. TLC: The Rf sample obtain with the same Rf Amphetamine Standard. GC: The Rt sample obtain with the same Rt Amphetamine Standard.

BUBXUF + + The results of the tests of SM2 (62) received confirmed that the mentioned sample contains amphetamine but we are not able to give a cuantification result .The sample 2 contains also caffeín as not controlled drug. C0ZZJN + + Sample 2015/1/SM-2, a white powder with acrid odour, gave a positive result for amphetamine, a controlled substance under national legislation on drugs. C77B7S + + Identified Amphetamine and coffeine CLWMLL + + The powder contains amfétamine and caféine. Amfétamine is a controlled substance in France. CML6FN + ANP Quantity of off-white powder weighing 0.21grams analysed and confirmed to contain Amphetamine. Caffeine was indicated however not confirmed. Amphetamine is a class B controlled drug within the provisions of the Misuse of Drugs Act 1971. CRVCAC + +

CXZ7SL - -

DF8IPB + + - Primary screening revealed Amphetamine - GC/MS and HPLC allowed identification of Amphetamine and Caffeine

DPMUDD + + Amfetamine is a Class B controlled drug subject to the provisions of the Misuse of Drugs Act 1971. DSTAS1 + + AMFETAMINE DXGEZT + + Amfetamine is controlled by law (K.B. 22/1/1998) EAEWNG + + found amfetamine with 5.1%ww EGOAAA + + amphetamine, cafeine EH8THK + + The sample contains amphetamine. The content of amphetamine (as amphetaminesulphate) is determined to 7 %. Amphetamine is a controlled substance in Norway. EIUUUK + + The sample also contains caffeine and creatine-monohydrate. EK1CYF + + sample found to contain amphetamine and caffeine EKXNNH + + The sample contains Amfetamine and Caffeine. ERGL66 + + Powder was found to contain amphetamine. FG6OYO + + the sample contains amphetamine (scheduled as ilicit drug in France), caffeine and creatine

Code Amfetamine Caffeine FSLFBU + + The white powder was analsyed and found to contain amphetamine. FSOGSM + + Test sample 2015/1/SM-2 contains amphetamine, a dangerous drug. It also contains caffeine. FUEK6X - +

G5W4WW - + For sample 2015/1/SM-2 was first a preliminary test to determine the presence of what kind of drugs we have used two Scott reagent tests (tyocianato of Cobalte) and the Marquis reagent. After a TLC and to that end we used a 20 × 20, silica as a solvent dichloromethane was used and how the Methanol eluent. Finally there was a gas chromatography using flame Ionization Detector (GC- FID), in the preparation of the samples used as solvent, chloroform/ethanol mixture and tetracosano (internal standard), and the column TRACSIL TRB-50 (50%) Diphenyl-(50%) dimethyl polysiloxane, Flow Rate of 1.5 ml/min and Pressure of 14.7 psi. GB3OEY + + One glass bottle containing 0.23 grammes of a powder containing 0.01 grammes of amphetamine. GBX7ZC + ANP

GFXM5C + - The chemical tests and the coincidence in the time of retention and mass fragmentogram with the material of reference used in the same conditions that the analyzed sample, indicate in this one the amfetamine presence. GGUVGQ + -

GMGJSG + + Amfetamine+Cafeine GOT2LZ + + AMPHETAMINE 5.7% AS BASE, CAFFEINE GTTTTX + +

H22O82 + + -Analysis of quantification on Amphetamine is not routinely carried out by our laboratory. -Substance detected include Caffeine. HFQF1Q + + caffein 30 % HKZ1VR + + The sample ICE2015/1/SM2 was found to contain Amphetamine and Caffeine. HPMMRG + + CAFEINE. HUA51A + + amfetamine, caffeine HV22C2 + + amphetamine(5%),cafeine ICJJYI + - Not quantificated ILI0KV + + amfetamine was detected by GC/MS screening and it was quantified by LC/MS/MS INVI3H + +

IO7IOO + + the sample SM2 contains amphetamine and caffeine

Code Amfetamine Caffeine IPDQJN + +

ISSSPG + + AMFETAMINE Y CAFEINE ITHPL9 + + contained caffeine IUPHSS + + The sample contains amphetamine IWH4C5 + + Caffeine IWII3P + + 5.02% JBOJJJ + + The sample contains amfetamine (5.6%) and caffeine. JMMMUB - +

JSAGFJ + - Field test employing the Marquis test showed positive. TLC analysis and HPLC was employed to confirm.

JZAFXP - + sample no 2 contain cocaine and some bulking agents. KFXSJH + + PRUEBAS CROMATICAS: MARQUIS, SCOTT, SIMON´S INSTRUMENTALES: FT-IR, GC-MS KHBFT2 + ANP Contains Amphetamine. KHMABJ + + The sample contains amphetamine, caffeine and creatine. LHLHFD + + Amfetamine and Caffeine LZIOS8 + + The percentage of amfetamine is 5.7 % MHLLML + + Usual as well. MMUMRC + + contained caffeine, creatinine N8RGKU + + Sample 2015/1/SM-2 consists of white powder. Amfetamine, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample. NANRGN + + In the sample is detected amphetamine and caffeine, NSUV95 - + The exhibit were found to contain caffeine and N-Methyliminopropylbenzene but no controlled substances. NXTOSM + +

NYXHZT + + CAFFEINE

Code Amfetamine Caffeine ODCD2V + + d,l amphetamine, caffeine, and creatine confirmed in 1 unit tested of 1 unit received. ODZFBN + + The sample contains amphetamine, caffeine and creatine. OIXWB8 + + amfetamine 5.4%ww, caffeine OWVZ9H + + Dark white powder that contains controlled substance AMPHETAMINE. P5ABC7 + + CREAM WHITE POWDER SAMPLE ANALYZED CONTAINS: AMPHETAMINE AND CAFFEINE.

P659G5 + +

PVZFPA + + Examination revealed the presence of Amphetamine Q772TV + + Caffeine Q8LGQQ + + *Results of screening tests were positive for primary amphetamines. *Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with amfetamine and caffeine. QCYBCZ - + Caffeine is not included in UN notified precursor chemicals. But in our country, Myanmar, we notified it as precursor chemical. QHH5X6 + + white powder containing caffeine and amfetamine QK1XXA + +

QMWQTQ - + Caffeine was identified in the sample QRWM3W + + Caffeine QRXCOO + + Orange color appear with Marquis test and purple color appear by Simon test with Acetone which indicates possible presence of Amfetamine.Purple color with Amalic Acid test indicates possible presence of Caffeine. Analysis by GCMS shows similarity as Amfetamine and Caffeine. QVHXRP + + CREATINE AND CAFFEINE WERE IDENTIFIED QYI8XO + + The sample contains : amphetamine and caffeine QYYLCY + + The sample contains amphétamine and cafein. Amphetamine is a scheduled as illicit drug. R2EIGV + + In the test sample 2015/1/SM-2 were detected amfetamine and caffeine RB8OK5 + + No determinada pureza, con creatina monohidrato y cafeina RHRRWR + + The sample was found to contain amphetamine and caffeine.

Code Amfetamine Caffeine RIJIJC + + the powder is a mixture of amfetamine sulfate, creatine hydrate, and caffeine. The concentration of amfetamine, as free base, in the sample is 5.4% by weight. RJRT8O + + amfetamine was as sulphat form RNIHSP + +

RQJY2X + + In the sample labeled as 2015/1 / SM-2 was found amphetamine and caffeine. RQQ9IG + + after chemical analysis was performed the sample contain . 1- amphetamine 5.1 % 2-caffeine RRERCL + +

RV1ATU + + Presence of caffeine. FTIR analysis detected the presence of creatine. S6JCMD + + The sample was found to contain amphetamine, caffeine and fructose. SEQGAQ + - sample contained amfetamine as a controlled drug SFILGT + +

SWTTQX + + Alpha Methyl Benzeneethanamine and caffeine are detected. TEKB5H + + the yellow powder contains amfetamine (4.6%ww) which is controlled by national law. The sample contains caffeine too. TFLCTJ + +

TK1XDK + + The sample found to contain Amphetamine TMIOPH + + The sample contain amphetamine, caffeine and creatine. TNQR0R + + contained amfetamine and cofeine TOTXN0 + + The sample contains amphetamine and caffeine. TRJR2R + + caffeine creatine UJJUU1 + + Amphetamine is a Class B controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). UJZXBO + + The test sample 2015/1/SM-2 was found to contain the controlled drug amphetamine. The sample was also found to contain caffeine. UU0EDU + + adulterant/diluents: caffeine, creatine V0TJCT + +

Code Amfetamine Caffeine V5A5C5 + + the sample contains amphetamine, caffeine, creatinine V7777W + + The powder was found to contain less than 5% amphetamine; caffeine was also detected. Amphetamine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class B drug. Caffeine is not controlled by the Misuse of Drugs Act 1971 (as amended). V7UKSS + + Narcotics: amphetamine, approximately 6 % as free base VHRVSQ + + Item 2015/1/SM-2 contained Amphetamine, at a purity of six per cent. VIBSI3 + +

VJEFF1 + + The sample contains amfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990. VVRYSV - + The Test sample 2015/1/SM-2 was analyzed by colour test and Thin Layer Chromatography technique and found to contain Caffeine. VWKVJV + +

VWVVHY + +

WATIXT + + sulphate amfetamine is present (6.8% w/w as base) with caffeine and creatine WH4B44 + ANP - WVV99T + + White powder containing Amfetamine (List II C 1971) 5.16% and other substance as adulterant: Caffeine X1WS11 + ANP

XI5JGO + +

XIXNGM + + ./. XKKPPR + + white powder, other compounds caffeine and creatine XNJQCT + + The sample contained amphetamine with caffeine. XODXXJ + +

XRRKRK + +

XY5KFG - ANP Mescaline was detected from sample 2015/1/SM-2. However the results are not indicated in the Analytical Results Form because it is not among the list of of drugs provided Y6HBAA + + The sample contains Amphetamine Hydrochloride (5.8% as base) with Caffeine. YN88GB - + La sustancia decomisada contiene cafeína

Code Amfetamine Caffeine YSMOUG + + Based on the above analysis, the sample was found to contain amphetamine and caffeine. YSNVND + + We found amphetamine as controlled drug and caffeine as adulterants YZSZMS + + La muestra contiene además cafeína Z9MTOM + + caffeine and creatine ZCYZZA + + CAFEINA ZO7E6M + + additional substances: creatine, caffeine

Identification methods for Test Sample 2

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Summary for test sample 2 The response summary of all 177 participating laboratories for the identification of SM- 2, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 2: Response Summary Participants: 177

Caffeine: 163 Amfetamine 163

False positives for Test Sample 2

Code Name Technique QK1XXA N-benzyl-2methylaziridine 150/180 NSUV95 N-methyliminopropylbenzene 190/180 G5W4WW Metamfetamine 150/171 JZAFXP Cocaine 161/180 XY5KFG Mescaline 141 CXZ7SL Heroin 150

False negatives for SM-2 (techinque(s) used or ANP)

Code: 9E9RV9 (180) A55MTH (180), FUEK6X (180), G5W4WW (150/171), JMMMUB (150) JZAFXP (180), NSUV95 (190), QCYBCZ (150), QMWQTQ (171), VVRYSV (150), XY5KFG (141), YN88GB (150) CXZ7SL (150) 1GHP1K (ANP)

Frequency of use of screening and identification techniques: Response Summary ResponseResponse Summary Summary Participants: 130 Participants:Participants: 177 171

SectionSection 140 141141142142 142 150150 150 160160 160 161161 161170 170171 171180 180190190 190 200200 200211 211220230 231 231 210 Screening 67 72 62 20 0 2 1 3 71 11 3 0 1 1 15 37.9% 40.7% 35.0% 11.3% 0.0% 1.1% 0.6% 1.7% 40.1% 6.2% 1.7% 0.0% 0.6% 0.6% 8.5% Identification 9 3 2 44 12 19 2 29 159 60 5 2 1 4 13 5.1% 1.7% 1.1% 24.9% 6.8% 10.7% 1.1% 16.4% 89.8% 33.9% 2.8% 1.1% 0.6% 2.3% 7.3% # labs using 73 72 62 51 12 19 2 30 160 63 8 2 1 4 23 this technique 41.2% 40.7% 35.0% 28.8% 6.8% 10.7% 1.1% 16.9% 90.4% 35.6% 4.5% 1.1% 0.6% 2.3% 13.0% 49

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Amfetamine Amfetamine Deviation Deviation Concentra Concentra Code from Code from tion z-score tion z-score robust robust (mass%) (mass%) average average GGUVGQ 0.61 5.0 -7.0 V7UKSS 5.65 0.1 0.0 4WAP4I 3.50 2.1 -2.9 DXGEZT 5.70 0.1 0.1 BFDDDR 3.69 1.9 -2.7 GOT2LZ 5.70 0.1 0.1 0BPIQK 4.00 1.6 -2.3 LZIOS8 5.70 0.1 0.1 V7777W 4.00 1.6 -2.3 RV1ATU 5.70 0.1 0.1 ATMMIK 4.40 1.2 -1.7 TRJR2R 5.70 0.1 0.1 333WNF 4.51 1.1 -1.5 X1WS11 5.70 0.1 0.1 TEKB5H 4.60 1.0 -1.4 RV1ATU 5.70 0.1 0.1 4QDDDD 4.68 0.9 -1.3 QRWM3W 5.73 0.1 0.2 C77B7S 4.80 0.8 -1.1 AM75RV 5.74 0.1 0.2 XI5JGO 4.80 0.8 -1.1 CRVCAC 5.77 0.2 0.2 6P0WWW 4.89 0.7 -1.0 QVHXRP 5.79 0.2 0.2 VWKVJV 4.90 0.7 -1.0 Y6HBAA 5.80 0.2 0.2 Z9MTOM 4.90 0.7 -1.0 XODXXJ 5.85 0.3 0.3 CML6FN 5.00 0.6 -0.9 ODCD2V 5.80 0.2 0.3 FG6OYO 5.00 0.6 -0.9 GB3OEY 5.90 0.3 0.4 HV22C2 5.00 0.6 -0.9 GTTTTX 5.90 0.3 0.4 1NBQEB 5.01 0.6 -0.9 EKXNNH 6.00 0.4 0.5 IWII3P 5.02 0.6 -0.8 UJJUU1 6.00 0.4 0.5 EAEWNG 5.10 0.5 -0.7 VHRVSQ 6.00 0.4 0.5 MMUMRC 5.10 0.5 -0.7 3I4END 6.05 0.5 0.6 RQQ9IG 5.10 0.5 -0.7 AG4RDN 6.14 0.5 0.7 XKKPPR 5.10 0.5 -0.7 2C5GCK 6.20 0.6 0.8 YZSZMS 5.10 0.5 -0.7 AFUPAX 6.22 0.6 0.8 WH4B44 5.14 0.5 -0.7 RJRT8O 6.30 0.7 0.9 WVV99T 5.16 0.4 -0.6 0B00MA 6.40 0.8 1.1 3XMCSS 5.20 0.4 -0.6 88CBR8 6.48 0.9 1.2 ILI0KV 5.25 0.4 -0.5 2KHKFK 6.50 0.9 1.2 9AQQ5Z 5.30 0.3 -0.4 DSTAS1 6.70 1.1 1.5 6HXWOM 5.40 0.2 -0.3 MHLLML 6.71 1.1 1.5 8Z1D82 5.40 0.2 -0.3 WATIXT 6.80 1.2 1.6 9G1IGG 5.40 0.2 -0.3 KHMABJ 7.10 1.5 2.1 EH8THK 5.40 0.2 -0.3 5D5Q5X 7.16 1.6 2.1 OIXWB8 5.40 0.2 -0.3 NYXHZT 7.92 2.3 3.2 RIJIJC 5.40 0.2 -0.3 HUA51A 8.30 2.7 3.7 999FTE 5.46 0.1 -0.2 QRXCOO 8.62 3.0 4.2 4IHDMJ 5.50 0.1 -0.2 TFLCTJ 8.62 3.0 4.2 4MQGMT 5.50 0.1 -0.2 DF8IPB 8.79 3.2 4.4 DPMUDD 5.50 0.1 -0.2 7CVHQG 9.00 3.4 4.7 ODZFBN 5.50 0.1 -0.2 INVI3H 19.48 13.9 19.2 TNQR0R 5.50 0.1 -0.2 IUPHSS 23.21 17.6 24.4 RRERCL 5.51 0.1 -0.2 5B9R5Q 23.90 18.3 25.4 72SXT7 5.52 0.1 -0.1 BCQF5M 27.83 22.2 30.8 IPDQJN 5.53 0.1 -0.1 R2EIGV 5.53 0.1 -0.1 1OFS4X 5.55 0.0 -0.1 ITHPL9 5.56 0.0 -0.1 1X1W9X 5.60 0.0 0.0 IWH4C5 5.60 0.0 0.0 JBOJJJ 5.60 0.0 0.0 50 2015/1-SM Copyright (c) 2015 UNODC Z-Score Report per Sample per Substance

Round: 2015/1 Robust average = 5.6% UNODC value = 5.5% Substance: SM-2; Amfetamine

4.0 3.7 3.2

3.0 2.1 2.1 2.0 1.6 1.5 1.5 1.2 1.2 1.1 0.9 0.8

1.0 0.8 0.7 0.6 0.5 0.5 0.5 0.4 0.4 0.3 2 0.3 0.2 0.2 0. 0.2 0.2 0.1 ‐7.0 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 4.2 4.7 24.4 30.8 4.2 4.4 19.2 25.4 0.0 0.0 0.0 0.1 0.1 0.1 0.1 ‐ 0.1 ‐ 0.2 0.2 0.2 0.2 0.2 0.2 ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ 0.2 ‐ 0.3 0.3 0.3 0.3 0.3 0.3 ‐ ‐ ‐ ‐ ‐ ‐ 0.4 ‐ 0.5 ‐ 0.6 ‐ 0.6 0.7 ‐ ‐ 0.7 0.7 0.7 0.7 0.7

‐1.0 ‐ ‐ ‐ ‐ ‐ 0.8 0.9 0.9 0.9 0.9 ‐ ‐ ‐ ‐ ‐ 1.0 1.0 1.0 ‐ ‐ ‐ 1.1 1.1 ‐ ‐ 1.3 ‐ 1.4 ‐ 1.5 ‐ 1.7 ‐2.0 ‐ 2.3 2.3 ‐ ‐ 2.7 ‐3.0 ‐ 2.9 ‐

‐4.0 RIJIJC JBOJJJ ILI0KV IWII3P TFLCTJ LZIOS8 ITHPL9 INVI3H DF8IPB XI5JGO IUPHSS TRJR2R 999FTE 72SXT7 R2EIGV IPDQJN 0BPIQK 3I4END C77B7S RJRT8O RRERCL UJJUU1 1OFS4X 8Z1D82 GTTTTX DSTAS1 XKKPPR 88CBR8 2KHKFK 4IHDMJ V7UKSS GOT2LZ XODXXJ TEKB5H 9G1IGG YZSZMS DXGEZT 2C5GCK NYXHZT WATIXT 4WAP4I HV22C2 EH8THK CRVCAC 5B9R5Q RQQ9IG IWH4C5 AFUPAX RV1ATU Y6HBAA RV1ATU GB3OEY 5D5Q5X 3XMCSS ODZFBN TNQR0R X1WS11 BFDDDR OIXWB8 FG6OYO CML6FN 1NBQEB 9AQQ5Z 1X1W9X QVHXRP EKXNNH VHRVSQ HUA51A VWKVJV KHMABJ ODCD2V V7777W 0B00MA 7CVHQG 333WNF AG4RDN WVV99T AM75RV ATMMIK BCQF5M QRXCOO WH4B44 MHLLML 4QDDDD EAEWNG GGUVGQ Z9MTOM DPMUDD 4MQGMT 6HXWOM 6P0WWW MMUMRC QRWM3W

Round: 2015/1

Dispersion of z-scores using different analytical techniques for the quantification of amfetamine in 2015/1 SM-2

10.0

8.0

6.0

4.0

2.0

0.0 z-score

-2.0

-4.0

-6.0

HPLC GC-FID GC/MS -8.0

-10.0

52 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Sample 3 Analysis

Identified substances for Test Sample 3

Code Identified Substances 15KHZZ None 1X1W9X No drug was found 333WNF Heroin 4QDDDD None. 8EKCQE anp 9E9RV9 None controlled drugs AM75RV None ATMMIK None BUBXUF NONE C0ZZJN - CLWMLL None DSTAS1 Negative G5W4WW Blank, no substance from the ICE menu included HKZ1VR NIL HPMMRG NONE HUA51A - INVI3H amphetamine ITHPL9 drugs not found IWII3P - JSAGFJ None detected. KHMABJ / LHLHFD - LZIOS8 SM-3 is a blank sample MHLLML None MMUMRC drugs not found NANRGN none OWVZ9H NONE Q772TV No found QCYBCZ - QMWQTQ JWH 073 QRXCOO 2-Propan-1-one QYI8XO The sample does not contain controlled substances RQJY2X none SWTTQX None TMIOPH - WH4B44 Heroin XI5JGO None XY5KFG Amphetamine Y6HBAA Nil YSMOUG None

Code Identified Substances YSNVND - ZO7E6M none

Statement of findings for Test Sample 3

Code [blank sample] 0B00MA 0BPIQK Any drug of abuse has been detected. 15KHZZ Green powder, negative for drugs. Detected traces of caffeine. 1NBQEB Negative 1OFS4X Sample does not contain any controlled drugs. 1QHP1K 1X1W9X Sample doesn`t contain any illegal substances 20222K No substance from the ICE menu included 2C5GCK Presence of substances from the ICE menu was not detected in the sample. Blank test sample is plant powder. 2JJEMT 2KHKFK there is no controlled substances in the sample 333WNF 3I4END 3XMCSS 4IHDMJ 4MQGMT no drugs can be found 4QDDDD 4WAP4I 5B9R5Q The powder was analysed for the presence of a range of controlled drugs but none could be confirmed. 5D5Q5X In this sample has not identified any drug, it has detected the presence of stigmasterol / sitosterol 6HXWOM No substance of toxicological interest is detected 6I9L3N the sample does not contain any controlled drugs 6P0WWW 6TZBOI 72SXT7 Test sample 2015/1/SM-3 contains plant material. 7CVHQG 88CBR8 We haven't found any drug in SM-3. 8EKCQE anp 8P8J9S Sample contains lactose 8Z1D82 999FTE 9AQQ5Z By using LC-MS and LC-MS-MS , the sample is free from any drugs 9E9RV9 Colorimetric reactions (CR) Negative, GC/MS retention time, and mass charge ratio (M/Z) No similar characteristics with the subtances used as pattern 9G1IGG A55MTH AFUPAX SM3 contains Glucose and Zaccharose AG4RDN This sample does not contain drugs.

Code [blank sample] AGX9RJ No drugs found AM75RV SM-3 gives negative to Marquis' test. No spot on TLC and no peak by GC and GCMS. No specific matched to controlled substances on FTIR ASAZSF No drugs found on the analyzed sample ATMMIK A sample of the vegetable matter was analysed and found to contain no controlled substance(s). AXEI96 No controlled drugs detected in sample 2015/1/SM-3 BCQF5M SM-3 is blank BFDDDR BUBXUF We have not found any controlled drug in the SM 3 (97) C0ZZJN Sample 2015/1/SM-3, a green powder with fruity odour, was not found to contain any controlled substance under national legislation on drugs. C77B7S CLWMLL The powder doesn't contain controlled substance in France. CML6FN Quantity of green powder weighing 0.22grams was analysed for the presence of controlled drugs within the provisions of the Misuse of Drugs Act 1971 with a negative result. There were no non- controlled drugs indicated in the sample also. CRVCAC CXZ7SL DF8IPB - Primary screening allowed negative results - GC/MS and HPLC allowed negative results - Iode test and FTIR (code 190) revealed strach DPMUDD No controlled substances were detected. DSTAS1 Negative DXGEZT Sample is a herbal mixture. EAEWNG EGOAAA EH8THK The sample is not identified. With the methods used, no controlled substance are detected in the sample. EIUUUK EK1CYF sample found to contain pthalate EKXNNH The sample does not contain any drugs. ERGL66 No controlled drugs detected. FG6OYO No illicit drug was detected in the sample. FSLFBU The green material was analysed for controlled drugs with a negative result. FSOGSM Test sample 2015/1/SM-3 does not contain dangerous drugs. FUEK6X G5W4WW For sample 2015/1/SM-3 was first a preliminary test to determine the presence of what kind of drugs we have used two Scott reagent tests (tyocianato of Cobalte) and the Marquis reagent. After a TLC and to that end we used a 20 × 20, silica as a solvent dichloromethane was used and how the Methanol eluent. Finally there was a gas chromatography using flame Ionization Detector (GC- FID), in the preparation of the samples used as solvent, chloroform/ethanol mixture and tetracosano (internal standard), and the column TRACSIL TRB-50 (50%) Diphenyl-(50%) dimethyl polysiloxane, Flow Rate of 1.5 ml/min and Pressure of 14.7 psi. GB3OEY One glass bottle containing 0.21 grammes of a solid which did not contain any substances controlled under the Dangerous Drugs Ordinance. GBX7ZC

Code [blank sample] GFXM5C GGUVGQ GMGJSG GOT2LZ GTTTTX H22O82 The sample did not contain any controlled substance HFQF1Q CELLULOSE , vegetal substance HKZ1VR The Sample ICE2015/1/SM3 was to contain no drug. HPMMRG IT IS CONTAINING PLANT MATERIALS HUA51A - HV22C2 henna ICJJYI not found any psycothropic or narcotic substance ILI0KV INVI3H a substance is related to drug - amphetamine IO7IOO the sample SM3 hasn't got drugs IPDQJN Negative ISSSPG ITHPL9 drugs not found IUPHSS IWH4C5 IWII3P - JBOJJJ No controlled drugs detected. JMMMUB JSAGFJ No drug was found. JZAFXP KFXSJH PRUEBAS CROMATICAS: MARQUIS, SCOTT, SIMON´S, CHEN CAO, DUQUENOIS-LEVINE. INSTRUMENTALES: FT-IR, GC-MS, UV-VISIBLE KHBFT2 Negative for controlled drugs. KHMABJ The sample is plant material. No drugs found in the samples. LHLHFD - LZIOS8 MHLLML Nothing relevant found. MMUMRC drugs not found

N8RGKU Sample 2015/1/SM-3 consists of green powder. No prohibited substances are detected in this sample. NANRGN Sample 2015/1 / SM-3 is pulverized plant material NSUV95 NXTOSM NYXHZT ODCD2V

Code [blank sample] ODZFBN Plant material without drugs. OIXWB8 OWVZ9H Olive green powder that contains none controlled substance. P5ABC7 GREEN POWDER SAMPLE ANALYZED NOT CONTAINS CONTROLLED DRUGS. P659G5 arabic gum PVZFPA Examination did not reveal the presence of any controlled substances. Q772TV Q8LGQQ Spectroscopic parameters obtained with sample are equivalent to those obtained with lactose. QCYBCZ QHH5X6 green vegetable material containing no substances in the ICE list QK1XXA QMWQTQ A synthetic Cannabinoid JWH 073 was identified in the sample. The percentage of JWH 073 in the sample was 3.68 . QRWM3W QRXCOO No reaction with Marquis test, Simon test, Chen-Kao test and Fast Blue B Salt test. Analysis by GCMS shows similarity as 2-Propan,1-One. QVHXRP QYI8XO The sample does not contain controlled substances QYYLCY R2EIGV In the test sample 2015/1/SM-3 were not detected substances RB8OK5 sin identificar, sustancia o material vegetal RHRRWR The sample did not contain any drugs. RIJIJC the powder doesn't contain controlled drugs RJRT8O RNIHSP RQJY2X In the sample labeled as 2015/1 / SM-3 no drugs were found RQQ9IG RRERCL RV1ATU S6JCMD No common controlled drug was detected. SEQGAQ sample was found to contain no drugs of abuse SFILGT SWTTQX Hexadecanoic Acid was detected. TEKB5H the green powder doesn't contain drugs controlled by national law. TFLCTJ TK1XDK no drugs found TMIOPH The sample is negative. TNQR0R Drugs not found TOTXN0 TRJR2R

Code [blank sample] UJJUU1 Not controlled drugs were detected in this powder. UJZXBO The test sample 2015/1/SM-3 do not found to contain the controlled drugs as well as the substances listed in the menu of ICE 2015/1. UU0EDU V0TJCT V5A5C5 mixture of spices V7777W Nothing of significance was detected. V7UKSS Negative VHRVSQ No controlled drug were detected in item 2015/1/SM-3. VIBSI3 VJEFF1 The analysis did not reveal any controlled drug according to french order, decree of February 22nd 1990. VVRYSV The Test sample 2015/1/SM-3 was analyzed by colour test and Thin Layer Chromatography technique and found not to contain the drug listed under Seized Material Samples VWKVJV VWVVHY None controlled substance was detected. WATIXT WH4B44 - WVV99T Herbal mixture possibly containing a synthetic cannabinoid that it was not possible to identify X1WS11 XI5JGO XIXNGM XKKPPR green powder - negative XNJQCT The sample contained traces of caffeine. XODXXJ XRRKRK XY5KFG Test sample 2015/1/SM-3 showed evidence that it contained amphetamines Y6HBAA No drugs Detected in the sample. YN88GB Se trata de restos vegetales. No fue posible identificar en qué tipo de vegetal consisten estos restos. YSMOUG Based on the above analysis, the sample was found to contain no controlled drug. YSNVND no drug content found in test sample YZSZMS Z9MTOM ZCYZZA CARBOHIDRATOS ZO7E6M methods used for identification: GC-MS, ATR, XRD, QTOF

Identification methods for Test Sample 3

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Summary for test sample 3 The response summary of all 177 participating laboratories for the identification of SM- 3, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 3:

Response Summary Participants: 177

SM-3 was a blank test sample prepared from plant material

False positives for Test Sample 3

Code Name Technique 333WNF Heroin 150/180 INVI3H Amfetamine 180 QMWQTQ JWH-073 171/180 WH4B44 Heroin 180 XY5KFG Amfetamine 141 JMMMUB JWH-073 160/180

Analyses not performed SM-3 Code: 8EKCQE

Frequency of use of screening and identification techniques: Response Summary ResponseResponse Summary Summary Participants: 130 Participants:Participants: 177 171 142 150 160 161 190 200 220

SectionSection 140140141 141142 142 150 160 161 170 171171180 180190 190200 200211 211230 231 231 210 Screening 67 72 62 20 0 2 1 3 71 11 3 0 1 1 15 37.9% 40.7% 35.0% 11.3% 0.0% 1.1% 0.6% 1.7% 40.1% 6.2% 1.7% 0.0% 0.6% 0.6% 8.5% Identification 9 3 2 44 12 19 2 29 159 60 5 2 1 4 13 5.1% 1.7% 1.1% 24.9% 6.8% 10.7% 1.1% 16.4% 89.8% 33.9% 2.8% 1.1% 0.6% 2.3% 7.3% # labs using 73 72 62 51 12 19 2 30 160 63 8 2 1 4 23 this technique 41.2% 40.7% 35.0% 28.8% 6.8% 10.7% 1.1% 16.9% 90.4% 35.6% 4.5% 1.1% 0.6% 2.3% 13.0% 65

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Sample 4 Analysis

Identified substances for Test Sample 4

Code Identified Substances 0B00MA HEROIN 0BPIQK heroin and products of acetalization of morphine 15KHZZ Heroin 1NBQEB heroine 1OFS4X Heroin, 6-MAM 1X1W9X Heroine 20222K Heroin 2C5GCK Heroine 2JJEMT heroine, monoacetylmorphine 2KHKFK Heroine 333WNF Heroin 3I4END Heroine 3XMCSS HEROIN 4IHDMJ heroin 4MQGMT heroin, morphine 4QDDDD Heroine free base. 4WAP4I heroin 5B9R5Q Heroin 5D5Q5X HEROIN 6HXWOM Heroin 6I9L3N heroin 6P0WWW Heroin 6TZBOI heroine, 6-monoacetylmorphine 72SXT7 Heroin 7CVHQG Heroin 88CBR8 heroin 8EKCQE heroin and codeine 8P8J9S Heroin 8Z1D82 Heroin 999FTE heroine, 6-MAM 9AQQ5Z Heroin 9E9RV9 Heroine, codeine acetate, 6-mono acetyl morphine, Papaverine and Noscapine. 9G1IGG heroine A55MTH Heroin, morphine AFUPAX Heroin base AG4RDN Heroin AGX9RJ Heroin AM75RV Heroin and Acetyl codeine ASAZSF Heroin ATMMIK Diacetylmorphine

Code Identified Substances AXEI96 Heroin BCQF5M Heroin BFDDDR Heroine BUBXUF HEROÍN C0ZZJN HEROIN C77B7S Heroine,acetylcodeine,6 monoacetylmorphine CLWMLL Heroin CML6FN Diamorphine (Heroin) CRVCAC heroin DF8IPB Heroine DPMUDD Heroin (Diamorphine), purity 74% DSTAS1 HEROIN DXGEZT Heroin EAEWNG heroin EGOAAA heroin EH8THK Heroine EIUUUK heroin EK1CYF Heroin, Morphine EKXNNH Heroin ERGL66 Diamorphine FG6OYO heroin FSLFBU Diamorphine (heroin) FSOGSM Heroin FUEK6X DIACETYLMORPHINE G5W4WW Heroine + nimetazepam GB3OEY Heroin GBX7ZC Heroin GFXM5C Heroine GGUVGQ Heroin GMGJSG Heroine GOT2LZ HEROIN GTTTTX HEROIN 69,1 % + 6-MONOACETYLMORPHINE + ACETYLCODEINE + NOSCAPINE + PAPAVERINE H22O82 Heroin HFQF1Q HEROIN HKZ1VR Heroin, 6-Acetylcodeine HPMMRG HEROINE, MONOACETILMORPHINE HUA51A heroine HV22C2 heroin(69%) ICJJYI heroin ILI0KV heroin INVI3H heroin IO7IOO Heroin, acetylcodeine, monoacetylmorphine and papaverine IPDQJN Diamorphine ISSSPG HEROINE

Code Identified Substances ITHPL9 heroin IUPHSS Heroin IWH4C5 Heroine IWII3P Heroin JBOJJJ Heroin JSAGFJ Heroin, Morphine and Codeine JZAFXP Heroine, 6MAM, Noscapine, Papaverine, acetylcodeine KFXSJH HEROINA KHBFT2 Heroin KHMABJ heroine LHLHFD Heroin LZIOS8 Heroine MHLLML Heroine MMUMRC heroin N8RGKU heroin NANRGN HEROINE NSUV95 Heroin NXTOSM heroine NYXHZT HEROIN ODCD2V heroin ODZFBN Heroine OIXWB8 heroin OWVZ9H HEROINE P5ABC7 HEROIN, ACETHYL MORPHINE, ACETHYL CODEINE. P659G5 Heroine and acetylcodein PVZFPA Heroin, Acetyl Codeine, Monoacetylmorphine, Noscapine and Papaverine Q772TV Heroine Q8LGQQ Heroin QCYBCZ Heroin. HCl QHH5X6 heroine, morphine, 6-monoacetylmorphine QK1XXA morphine( trace)- codeine( trace) papaverine- 6- acetyl mophine - meconin - noscapine- acetyl codeine QMWQTQ Heroin Base and Morphine QRWM3W Heroin QRXCOO Heroin QVHXRP HEROIN QYI8XO Heroin QYYLCY Heroin base R2EIGV Heroin RB8OK5 heroin RHRRWR Heroin RIJIJC heroin RJRT8O heroin RNIHSP heroine, morphine

Code Identified Substances RQJY2X heroin RQQ9IG heroin RRERCL heroin RV1ATU Heroin S6JCMD diamorphine SEQGAQ heroin SFILGT heroin, morphine, 6-MAM, noscapine, acetylcodeine, papaverine SWTTQX Heroin TEKB5H heroin TFLCTJ heroin TK1XDK Heroin TMIOPH heroin TNQR0R Heroine TOTXN0 Heroin TRJR2R heroin UJJUU1 DIAMORPHINE (HEROIN) UJZXBO Heroin UU0EDU heroin V0TJCT Heroin V5A5C5 heroine V7777W Diamorphine V7UKSS Heroine VHRVSQ Diamorphine VIBSI3 heroin VJEFF1 Heroin VVRYSV Heroin, Acetyl Codeine, 6-monoacetyl Morphine and Papaverine VWKVJV heroin VWVVHY Heroin WATIXT heroin WH4B44 Heroin,Morphine WVV99T Heroin X1WS11 Heroine XI5JGO Heroin XIXNGM Heroin XKKPPR heroin XNJQCT Heroine XY5KFG Morphine, cocaine Y6HBAA Diamorphine, Morphine, 6-monoacetylmorphine and Acetylcodeine YN88GB Heroína YSMOUG Heroin and monoacetylmorphine YSNVND Heroin YZSZMS Heroina Z9MTOM heroin ZCYZZA HEROINA - ACETILCODEINA

Code Identified Substances ZO7E6M heroin base

Statement of findings for Test Sample 4

Code Heroin Morphine minor comp. 0B00MA + - Base Heroin, Acetyilcodeine, 6.Monoacetylmorphine, Papaverine and Noscapine, purity 72,6+/- 3,29% (w/w) 0BPIQK + + It has been detected the presence of heroin and subproducts of the acetalization of morphine in the sample. 15KHZZ + - Beige powder containing heroin. Also detected acetylcodeine, monoacetylmprphine, papaverine and noscapine. 1NBQEB + - After analyzing the sample with colorimetrics tests and confirmation with GC/MS methods and subsequent quantifcation with GC/FID, we confident that the sample contains 74.64 % of heroine base. Other substances caffeine 1OFS4X + - Sample contains 72.2 ± 4.2 % heroin base. 6-monoacetylmorphine, acetylcodeine, papaverine and noscapine were also detected. 1QHP1K ANP ANP

1X1W9X + - Sample contain 82.8 % of heroine 20222K + - Trace amounts of Acetilcodeine 2C5GCK + - Presence of heroine was detected in the sample. The sample also contained acetylcodeine, 6- MAM, papaverine, noscapine and trace amounts of meconine, morphine and acetylthebaol. 2JJEMT + - acetilcodeine traces 2KHKFK + - we found heroine, 6-MAM, acetylcodeine, papeverine and noscapine in the sample 333WNF + -

3I4END + - 6-monoacetylmorphine acethylcodeine 3XMCSS + - In the sample there are all the opium alcaloids: 6-MAM, ACETYLCODEINE, MORPHINE, PAPAVERINE, NARCOTINE 4IHDMJ + - Powder containing heroin 4MQGMT + + includes a few (<%1) morphine as trace 4QDDDD + - Sample also include codeine, papaverine, noscapine and 6-acetylomorphine. 4WAP4I + - we were found MAM-6 and Acetyl codeine in the sample 5B9R5Q + - Analysis detected the presence of heroin (diamorphine) with an approximate purity of 68% (as base).

Code Heroin Morphine minor comp. 5D5Q5X + ANP The sample contains a controlled substance as heroin, and other substances such as codeine and noscapine 6HXWOM + + 6-MAM, morphine, acetylcodeine, papaverine and noscapine are also detected. It is a sample of semi synthetic heroine as acetylcodeine is detected, partially degradated (6-MAM is detected) with an "usual" concentration of heroin in street samples. 6I9L3N + ANP The sample contains heroine 6P0WWW + - Heroin 72,79%, Acetylcodeine and Monoacetylmorphine. 6TZBOI + - The sample also contain acetylcodeine, noscapine, papaverine. 72SXT7 + - Test sample 2015/1/SM-1 contains heroin base 75.92 %, m/m with impurities. 7CVHQG + - Acetylcodeine and Lactose 88CBR8 + - We have found heroin and acetylcodeine by using GC-MS. 8EKCQE + - analyzed by GCMS 8P8J9S + - Sample contains heroin base (72,9%), 6-acetylmorphine, 6-acetylcodeine, papaverine and noscapine. 8Z1D82 + - The sample SM4 was found to contain the controlled substance Heroin. 999FTE + - meconine, acetylcodeine, noscapine, popaverine 9AQQ5Z + + By using LC-MS and LC-MS-MS , th esample contain Heroin 80 % w/w , 6-monoacetylmorphine, Papaverine and Noscapine. Morphine found in trace amount. 9E9RV9 + - Cobalt thiocyanate (CT) and Marquis reagent (MR), GC/MS retention time and mass charge ratio (M/Z) similar characteristics with the substances used as standard or pattern 9G1IGG + -

A55MTH + +

AFUPAX + - SM4 contains 70.4 % Heroine base AG4RDN + - This sample is heroin. AGX9RJ + - acetylcodeine, papaverine, noscapine, 6-O-monoacetylmorphine AM75RV + - SM-4 gives positive to Marquis', Mecke and Froehde reagent. By TLC, found spots of Heroin and Acetyl Codeine. By GCMS, found peaks of Heroin, Acetyl Codeine and traces of codeine, 6-MAM and papaverine. Quantitaion with GC, SM-4 contains Heroin base 73.15%

Code Heroin Morphine minor comp. ASAZSF + - Sample also contain 6-monoacetylmorphine, acetylcodeine ATMMIK + - A sample of this powder was analysed an found to contain diacetylmorphine at a purity of 71%. AXEI96 + - Sample 2015/1/SM-1 contain 68.1% +/- 7.4% Heroin. BCQF5M + - SM-4 is positive for heroin. BFDDDR + - The sample obtains with positive result with Marquis reagent. TLC: The Rf sample obtain with the same Rf Heroine Standard. GC: The Rt sample obtain with the same Rt Heroine Standard.

BUBXUF + - The results of the tests of SM4 (45) received confirmed that the mentioned sample contains heroín with 72.7 percentage by weight (72.7%). C0ZZJN + - Sample 2015/1/SM-4, a beige odourless powder, gave a positive result for heroin, a controlled substance under national legislation on drugs. C77B7S + - Identified Heroine,acetylcodeine,6 monoacetylmorphine and noscapine CLWMLL + - The powder contains 74% of héroïne as free base and 15% of narcotine. Heroïne is a controlled substance in France. CML6FN + - Quantity of brown powder weighing 0.19 grams analysed and confirmed to contain Diamorphine. Diamorphine is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971. CRVCAC + -

CXZ7SL + -

DF8IPB + - - Primary screening allowed positive results for Heroine - GC/MS , FTIR and HPLC confirmed above results DPMUDD + - Diamorphine is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971. DSTAS1 + - HEROIN DXGEZT + - Heroin is controlled by law (K.B. 31/12/1930, changed by K.B. 8/10/1963) EAEWNG + - found heroin with 69.4%ww EGOAAA + - heroin EH8THK + - The sample contains heroine. The content of heroine (as heroinebase) is determined to 83 %. Heroine is a controlled substance in Norway. EIUUUK + - The sample also contains acetil-codeine, noscapine, papaverin and 6-MAM (6-monoacetilmorphine).

Code Heroin Morphine minor comp. EK1CYF + + sample found to contain Heroin, Morphine, Acetylcodeine and 6-monoacetylmorphine EKXNNH + - The sample contains Heroin, Papaverine, Noscapine, 6-acetylmorphine and Acetylcodein. ERGL66 + - Powder was found to contain diamorphine, purity was determined to be 69% calculated as base. FG6OYO + - the sample contains heroin (scheduled as illicit drug in France)and noscapine FSLFBU + - The brown powder was analysed and found to contain diamorphine. FSOGSM + - Test sample 2015/1/SM-4 contains heroin. FUEK6X + - THE SAMPLE SM-4 WAS ANALYSED AND FOUND TO TO CONTAIN DIACETYLMORPHINE A DRUG G5W4WW + - For sample 2015/1/SM-4 was first a preliminary test to determine the presence of what kind of drugs we have used two Scott reagent tests (tyocianato of Cobalte) and the Marquis reagent. After a TLC and to that end we used a 20 × 20, silica as a solvent dichloromethane was used and how the Methanol eluent. Finally there was a gas chromatography using flame Ionization Detector (GC- FID), in the preparation of the samples used as solvent, chloroform/ethanol mixture and tetracosano (internal standard), and the column TRACSIL TRB-50 (50%) Diphenyl-(50%) dimethyl polysiloxane, Flow Rate of 1.5 ml/min and Pressure of 14.7 psi. GB3OEY + - One glass bottle containing 0.22 grammes of a powder containing 0.15 grammes of heroin. GBX7ZC + ANP

GMGJSG + - Heroin+6MAM+Acetyl-Codein+Papaverine+Noscapine GOT2LZ - - HEROIN 79.4% AS BASE GTTTTX + -

H22O82 + - The sample contained 67.3% w/w Heroin. HFQF1Q + - NOSCAPINE 17%, ACETYLCODEINE, PAPAVERIN, O6 MAM HKZ1VR + - The sample ICE2015/1/SM4 was found to contain Heroin and 6- Acetylcodeine. HPMMRG + - CODEINE, PAPAVERINE, NOSCAPINE AND TEBAINE HUA51A + - acetylcodeine, monoacetylmorphine, papaverine, noscapine HV22C2 + ANP heroin(69%), papaverine,noscapine

Code Heroin Morphine minor comp. ICJJYI + - quantification results: 76% +/-7 ILI0KV + - heroin was detected by GC/MS screening and it was quantified by GC/FID using calibration curve. INVI3H + - a substance is related to drug - heroin IO7IOO + - the sample SM4 contains Heroin, acetylcodeine, monoacetylmorphine and papaverine IPDQJN + - Diamorphine (commonly known as Herion) ISSSPG + - HEROIN ITHPL9 + - contained acetylcodeine, 6-monoacetylmorphine, papaverine, noscapine IUPHSS + - The sample contains heroin IWH4C5 + - Acetylcodeine, 6-MAM, Noscapine, Papaverine IWII3P + - 71.8% JBOJJJ + - The sample contains heroin (70.8%). JMMMUB + -

JSAGFJ + +

Field test employing Marquis test was positive, TLC AND HPLC analysis performed to confirm. JZAFXP + - sample no4 contains heroin, its origination is from opium without extraction KFXSJH + ANP PRUEBAS CROMATICAS: MARQUIS, MECKE, MICROCRISTALES INSTRUMENTALES: ESPECTROMETRIA UV, FT-IR, GC-MS KHBFT2 + - Contains Heroin (Diamorphine). KHMABJ + - The sample contains heroine, acetyl codeine, monoacetylmorphine, papaverine, noscapine. LHLHFD + - Heroin LZIOS8 + - The percentage of heroine is 63 % MHLLML + - Usual substance, unusual high potency. MMUMRC + - contained acetylcodeine, 6-monoacetylmorphine, papaverine, noscapine N8RGKU + - Sample 2015/1/SM-4 consists of light-brown powder. Heroin, a prohibited substance included in the National Law for Narcotics, is found to be present in this sample.

Code Heroin Morphine minor comp. NANRGN + - Sample 2015/1 / SM-4 is positive for heroin and also alcaloidales impurities such as 6- and acetylcodeine detected monoacetylmorphine NSUV95 + + The exhibit were found to contain Diacetylmorphine (heroin), 6-Monoacetylmorphine, Acetylcodeine, Morphine, Noscapine and meconin. NXTOSM + ANP

NYXHZT + - ACETYLCODEINE ODCD2V + - Heroin base confirmed in 1 unit tested of 1 unit received. ODZFBN + - The sample contains heroine (6-monoacetylmorphine, diacetylmorphine, papaverine, noscapine). OIXWB8 + - heroin 70.7%ww, 6-MAM (5,0%ww), acetyl-codeine OWVZ9H + - Light brown powder that conatins controlled substance HEROINE. P5ABC7 + - BROWN POWDER SAMPLE ANALYZED CONTAINS: HEROIN, ACETHYL MORPHINE, ACETHYL CODEINE. P659G5 + -

PVZFPA + - Examination revealed the presence of Heroin. Q772TV + - AcetylCodeine and Narcotine Q8LGQQ + - *Results of screening tests were positive for opiates. *Retention time and fragmentation pattern obtained with sample are equivalent to those obtained with heroin, 6-monoacetylmorphine and acetylcodeine. QCYBCZ + -

QHH5X6 + + brown powder containing heroine, morphine and 6-monoacethylmorphine, acethylcodeine, papaverine, noscapine QK1XXA + -

QMWQTQ + + Heroin (diacetylmorphine) and Morphine were identified in the sample. The percentage of the heroin in the sample was 66.88. QRWM3W + - acetycodenine, 6-monoacetylmorphine, papaverin and noscapine QRXCOO + - Violet color with Marquis test and yellow changing to light green color with Nitric Acid test indicates possible presence of Heroin. Analysis by GCMS shows the similarity as Heroin. QVHXRP + - HEROIN IS PRESENT IN BASE FORM. ACETYLCODEINE, 6-MAM, PAPAVERINE AND NOSCAPINE WERE IDENTIFIED QYI8XO + - The sample contains Heroin

Code Heroin Morphine minor comp. QYYLCY + - The sample contains heroin base ,6- mono-acetyl morphine and acetyl-codeine. Heroin is a scheduled as illicit drug. R2EIGV + - In the test sample 2015/1/SM-4 were detected heroin, 6-monoacetylmorphine and acetylcodeine RB8OK5 + - base, con acetato de codeina y monoacetil morfina como impurezas RHRRWR + ANP The sample was found to contain 67.90 % of heroin. RIJIJC + - The powder contains heroin and other opiates. The concentration of heroin, as free base, in the sample is 68.3% by weight. RJRT8O + ANP Heroin was as free base form RNIHSP + +

RQJY2X + - In the sample labeled as 2015/1 / SM-4 was found heroin, noscapine and papaverine. RQQ9IG + - after chemical analysis was performed the sample contain . 1- heroin 90.3% 2- alkaloid substance RRERCL + -

RV1ATU + - The GC/MS detected acetylcodeine, monoacetylmorphine and papaverine, but one can't confirm this substances because it haven't the standards. S6JCMD + - The sample was found to contain 72.0% of diamorphine (as base). The sample was also found to contain O6-MAM, papaverine and narcotine. SEQGAQ + - sample contained heroin HCl as a controlled drug SFILGT + +

SWTTQX + + Heroin detected. TEKB5H + - the light-brown powder contains heroin (69.1%ww) and 6-MAM (5.3%) which are substances controlled by national law. TFLCTJ + -

TK1XDK + - The sample found to contain Heroin TMIOPH + - The sample contain heroin. TNQR0R + - contained heroine and trace of acetylcodeine, 6-monoacetylmorphine, papaverine, noscapine TOTXN0 + - The sample contains heroin, acetylcodeine, papaverine and 6-monoacetylmorphine. TRJR2R + -

Code Heroin Morphine minor comp. UJJUU1 - - Diamorphine (Heroin) is a Class A controlled drug under the provisions of the Misuse of Drugs Act 1971 (as amended). UJZXBO + - The test sample 2015/1/SM-4 was found to contain the controlled drug heroin. UU0EDU + - others: 6-MAM, acetil-codeine, papaverine, noscapine V0TJCT + -

V5A5C5 + - sample contains heroin, acetylcodeine,6monoacetylmorphine,papaverine and noscapine V7777W + - The powder was found to contain 71% diamorphine. Diamorphine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class A drug. V7UKSS + - Narcotics: heroine, approximately 68 % as free base VHRVSQ + - Item 2015/1/SM-4 contained Diamorphine (commonly known as "heroin"), at a purity of seventy-one per cent. VIBSI3 + -

VJEFF1 + - The sample contains heroin which is listed as a controlled drug according to french order, appendix I of February 22nd 1990. VVRYSV + - The Test sample 2015/1/SM-1 was analyzed by colour test and Thin Layer Chromatography technique and found to contain Heroin, Acetyl Codeine, 6-monoacetyl Morphine and Papaverine. VWKVJV + -

VWVVHY + -

WATIXT + - Heroin base is present (74% w/w) with noscapine papaverine 6MAM and acetylcodeine WH4B44 + ANP - WVV99T + - Brown powder containing Heroin (List I & IV CU 1961) X1WS11 + ANP

XI5JGO + -

XIXNGM + - ./. XKKPPR + - brownish powder, other compounds - acetylcodeine, 6-MAM, papaverine and noscapine XNJQCT + - The sample contained heroine with 6-Acetylmorphine, Acetylcodeine, Papaverine and Noscapine. XODXXJ + -

Code Heroin Morphine minor comp. XRRKRK + -

XY5KFG - + There was evidence that sample 2015/1/SM-4 contained morphine and cocaine Y6HBAA + + The sample contains Diamorphine (63.5% as base), Morphine, 6-Monoacetylmorphine, Papaverine and Acetylcodeine which are constituents of Heroin. YN88GB + ANP La sustancia decomisada contiene heroína. YSMOUG + - Based on the above analysis, the sample was found to contain heroin, monoacetylmorphine, acetylcodeine, papaverine and noscapine. YSNVND + - We found Heroin as controlled drug and also found acetylcodeine, Monoacetylmorphine (MAM), papaverine, and noscapine in test sample YZSZMS + -

Z9MTOM + - acetilcodeine, 6-MAM, noscapine ZCYZZA + -

ZO7E6M + - 6-monoacethylmorphine, acethylcodeine

Identification methods for Test Sample 4

Legend: S ... used for Screening I ... used for Identification SI ... used for both

Summary for test sample 4 The response summary of all 177 participating laboratories for the identification of SM- 4, frequency of use of screening and identification techniques and false positives and negatives: Identification of test sample 4:

Response Summary Participants: 177

Heroin 173 Morphine (minor component) 15

False positives for Test Sample 4

Code Name Technique XY5KFG Cocaine 141/200 G5W4WW Nimetazepam 150/171

False negatives for SM-4 (technique(s) used or ANP) Code: UJJUU1 (180/190), XY5KFG) (141/200), 1QHP1K (ANP)

Frequency of use of screening and identification techniques: Response Summary ResponseResponse Summary Summary Participants: 130 Participants:Participants:Section 177 171140 142142 150 150 160 160 161 161 170 171 180190 190 200 200 211220 231

Section 140140141 141142 142150 150 160 161 170 171 180 190 200200211 211230 231 231 210 Screening 67 72 62 20 0 2 1 3 71 11 3 0 1 1 15 37.9% 40.7% 35.0% 11.3% 0.0% 1.1% 0.6% 1.7% 40.1% 6.2% 1.7% 0.0% 0.6% 0.6% 8.5% Identification 9 3 2 44 12 19 2 29 159 60 5 2 1 4 13 5.1% 1.7% 1.1% 24.9% 6.8% 10.7% 1.1% 16.4% 89.8% 33.9% 2.8% 1.1% 0.6% 2.3% 7.3% # labs using 73 72 62 51 12 19 2 30 160 63 8 2 1 4 23 this technique 41.2% 40.7% 35.0% 28.8% 6.8% 10.7% 1.1% 16.9% 90.4% 35.6% 4.5% 1.1% 0.6% 2.3% 13.0%

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 4

Heroin Heroin Deviation Deviation Concentrat Concentrat Code from Code from ion z-score ion z-score robust robust (mass%) (mass%) average average 4MQGMT 0.10 70.9 -17.4 QVHXRP 70.40 0.6 -0.1 A55MTH 0.16 70.8 -17.4 RRERCL 70.60 0.4 -0.1 JSAGFJ 1.14 69.9 -17.1 VWVVHY 70.60 0.4 -0.1 DF8IPB 9.99 61.0 -14.9 XODXXJ 70.60 0.4 -0.1 FUEK6X 23.85 47.2 -11.5 OIXWB8 70.70 0.3 -0.1 BFDDDR 24.58 46.4 -11.4 JBOJJJ 70.80 0.2 0.0 A55MTH 27.93 43.1 -10.5 XIXNGM 70.80 0.2 0.0 HUA51A 41.20 29.8 -7.3 EKXNNH 71.00 0.0 0.0 7CVHQG 59.05 12.0 -2.9 ITHPL9 71.00 0.0 0.0 RB8OK5 60.00 11.0 -2.7 V7777W 71.00 0.0 0.0 RJRT8O 62.30 8.7 -2.1 VHRVSQ 71.00 0.0 0.0 5D5Q5X 63.00 8.0 -1.9 VJEFF1 71.00 0.0 0.0 LZIOS8 63.00 8.0 -1.9 ILI0KV 71.02 0.0 0.0 Y6HBAA 63.50 7.5 -1.8 MHLLML 71.16 0.2 0.1 0BPIQK 64.00 7.0 -1.7 IWH4C5 71.20 0.2 0.1 JZAFXP 64.00 7.0 -1.7 3I4END 71.28 0.3 0.1 KHMABJ 65.80 5.2 -1.3 AG4RDN 71.32 0.3 0.1 ZO7E6M 65.95 5.1 -1.2 GB3OEY 71.40 0.4 0.1 UJJUU1 66.00 5.0 -1.2 ATMMIK 71.42 0.4 0.1 WVV99T 66.82 4.2 -1.0 XKKPPR 71.50 0.5 0.1 QMWQTQ 66.88 4.1 -1.0 88CBR8 71.78 0.8 0.2 YZSZMS 66.90 4.1 -1.0 DSTAS1 71.80 0.8 0.2 X1WS11 67.24 3.8 -0.9 IWII3P 71.80 0.8 0.2 H22O82 67.30 3.7 -0.9 RV1ATU 71.90 0.9 0.2 V7UKSS 67.75 3.3 -0.8 RV1ATU 71.90 0.9 0.2 5B9R5Q 67.90 3.1 -0.7 S6JCMD 72.00 1.0 0.3 RHRRWR 67.90 3.1 -0.7 1OFS4X 72.20 1.2 0.3 AXEI96 68.10 2.9 -0.7 4MQGMT 72.20 1.2 0.3 4QDDDD 68.27 2.7 -0.7 CRVCAC 72.20 1.2 0.3 RIJIJC 68.30 2.7 -0.7 C77B7S 72.30 1.3 0.3 QHH5X6 68.62 2.4 -0.6 ODCD2V 72.90 1.9 0.4 IPDQJN 68.70 2.3 -0.6 0B00MA 72.60 1.6 0.4 R2EIGV 68.90 2.1 -0.5 BUBXUF 72.70 1.7 0.4 QRWM3W 68.99 2.0 -0.5 6P0WWW 72.79 1.8 0.5 CML6FN 69.00 2.0 -0.5 MMUMRC 72.80 1.8 0.5 DXGEZT 69.00 2.0 -0.5 8P8J9S 72.90 1.9 0.5 ERGL66 69.00 2.0 -0.5 FG6OYO 73.00 2.0 0.5 HV22C2 69.00 2.0 -0.5 Q8LGQQ 73.00 2.0 0.5 GTTTTX 69.10 1.9 -0.5 VWKVJV 73.00 2.0 0.5 TEKB5H 69.10 1.9 -0.5 KFXSJH 73.04 2.0 0.5 EAEWNG 69.40 1.6 -0.4 AM75RV 73.15 2.2 0.5 2C5GCK 69.70 1.3 -0.3 Z9MTOM 73.30 2.3 0.6 4IHDMJ 69.80 1.2 -0.3 333WNF 73.43 2.4 0.6 NYXHZT 69.81 1.2 -0.3 6I9L3N 73.70 2.7 0.7 GGUVGQ 70.00 1.0 -0.2 999FTE 73.77 2.8 0.7 6HXWOM 70.10 0.9 -0.2 4WAP4I 73.80 2.8 0.7 VIBSI3 70.20 0.8 -0.2 CLWMLL 74.00 3.0 0.7 AFUPAX 70.40 0.6 -0.1 DPMUDD 74.00 3.0 0.7 WATIXT 74.00 3.0 0.7 TNQR0R 74.10 3.1 0.8 ODZFBN 74.30 3.3 0.8

Heroin Deviation Concentrat Code from ion z-score robust (mass%) average 2KHKFK 74.50 3.5 0.9 1NBQEB 74.64 3.6 0.9 BCQF5M 74.96 4.0 1.0 9G1IGG 75.00 4.0 1.0 72SXT7 75.92 4.9 1.2 ICJJYI 76.00 5.0 1.2 WH4B44 76.00 5.0 1.2 NXTOSM 76.30 5.3 1.3 IUPHSS 77.66 6.7 1.6 8Z1D82 78.00 7.0 1.7 GOT2LZ 79.40 8.4 2.1 HFQF1Q 79.43 8.4 2.1 9AQQ5Z 80.00 9.0 2.2 INVI3H 80.49 9.5 2.3 TRJR2R 82.00 11.0 2.7 1X1W9X 82.80 11.8 2.9 EH8THK 83.40 12.4 3.1 V5A5C5 83.52 12.5 3.1 XI5JGO 84.30 13.3 3.3 TFLCTJ 86.30 15.3 3.8 QRXCOO 89.54 18.5 4.6 RQQ9IG 90.30 19.3 4.7 3XMCSS 92.80 21.8 5.4

*) Concentration: w/w %

Round: 2015/1 Robust average = 71.1% UNODC value = 72.2% Substance: SM-4; Heroin

4.0 3.8 3.3 3.1 3.1

3.0 2.9 2.7 2.3 2.2 2.1 2.1 2.0 1.7 1.6 1.3 1.2 1.2 1.2 1.0 1.0 0.9 0.9

1.0 0.8 0.8 0.7 0.7 0.7 0.7 0.7 0.7 0.6 0.6 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.5 0.5 0.4 0.4 0.3 0.3 0.3 0.3 0.3 1 0.2 0.2 0.2 0.2 0.2 0. 0.1 0.1 17.4 0.1 17.4 7.3 0.1 ‐ 17.1 14.9 0.1 11.5 0.1 ‐ ‐ ‐ ‐ 0.0 11.4 10.5 0.0 0.0 0.0 0.0 0.0 ‐ ‐ ‐ 0.0 4.6 4.7 5.4 0.0 0.0 0.1 0.1 0.1 0.1 ‐ ‐ ‐ ‐ 0.1 0.1 ‐ ‐ 0.2 0.2 ‐ 0.2 ‐ ‐ 0.3 0.3 0.3 ‐ ‐ ‐ 0.4 ‐ 0.5 0.5 0.5 0.5 0.5 0.5 0.5 ‐ ‐ 0.5 ‐ ‐ ‐ ‐ ‐ ‐ 0.6 0.6 ‐ ‐ 0.7 0.7 ‐ 0.7 ‐ ‐ 0.7 0.7

‐1.0 0.8 ‐ ‐ ‐ 0.9 0.9 ‐ ‐ 1.0 1.0 1.0 ‐ ‐ ‐ 1.2 1.2 ‐ 1.3 ‐ ‐ 1.7 1.7

‐2.0 ‐ ‐ 1.8 ‐ 1.9 1.9 ‐ ‐ 2.1 ‐ 2.7 ‐3.0 ‐ 2.9 ‐

‐4.0 JBOJJJ ILI0KV VIBSI3 TFLCTJ JSAGFJ LZIOS8 INVI3H JZAFXP 999FTE R2EIGV RJRT8O RRERCL UJJUU1 8Z1D82 DSTAS1 FUEK6X 9G1IGG 88CBR8 V7UKSS TEKB5H 4IHDMJ V5A5C5 DXGEZT WATIXT HV22C2 RQQ9IG 5B9R5Q CRVCAC RV1ATU IWH4C5 OIXWB8 ODZFBN 1NBQEB HFQF1Q X1WS11 1X1W9X VWKVJV QVHXRP EKXNNH VHRVSQ KHMABJ QHH5X6 0B00MA ODCD2V 333WNF AG4RDN ATMMIK 7CVHQG AM75RV A55MTH WH4B44 Q8LGQQ NXTOSM 4QDDDD EAEWNG GGUVGQ DPMUDD 4MQGMT 4MQGMT QMWQTQ MMUMRC

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken88 that an anomaly has occurred that requires investigation.

Z-Score Report per Sample per Substance

Round: 2015/1

Dispersion of z-scores using different analytical techniques for the quantification of heroin in 2015/1 SM-4 10.0

8.0

6.0

4.0

2.0

0.0 z-score

-2.0

-4.0

-6.0

HPLC -8.0 GC-FID GC/MS

-10.0

89 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

The Laboratory and Scientific Section UNODC, International Centre Wagramer Strasse 5, P.O. Box 500 A-1400, Vienna, AUSTRIA Email: [email protected]