SCIENTIFIC and TECHNICAL NOTES Colour Tests for Precursor
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
House Bill No. 2191
SECOND REGULAR SESSION HOUSE BILL NO. 2191 99TH GENERAL ASSEMBLY INTRODUCED BY REPRESENTATIVE QUADE. 5582H.01I D. ADAM CRUMBLISS, Chief Clerk AN ACT To repeal section 579.060, RSMo, and to enact in lieu thereof one new section relating to controlled substances, with penalty provisions. Be it enacted by the General Assembly of the state of Missouri, as follows: Section A. Section 579.060, RSMo, is repealed and one new section enacted in lieu 2 thereof, to be known as section 579.060, to read as follows: 579.060. 1. A person commits the offense of unlawful sale, distribution, or purchase of 2 over-the-counter methamphetamine precursor drugs if he or she knowingly: 3 (1) Sells, distributes, dispenses, or otherwise provides any number of packages of any 4 drug product containing detectable amounts of ephedrine, levomethamphetamine, 5 phenylpropanolamine, propylhexedrine, or pseudoephedrine, or any of their salts, optical 6 isomers, or salts of optical isomers, in a total amount greater than nine grams to the same 7 individual within a thirty-day period, unless the amount is dispensed, sold, or distributed 8 pursuant to a valid prescription; or 9 (2) Purchases, receives, or otherwise acquires within a thirty-day period any number of 10 packages of any drug product containing any detectable amount of ephedrine, 11 levomethamphetamine, phenylpropanolamine, propylhexedrine, or pseudoephedrine, or any 12 of their salts or optical isomers, or salts of optical isomers in a total amount greater than nine 13 grams, without regard to the number of transactions, unless the amount is purchased, received, 14 or acquired pursuant to a valid prescription; or 15 (3) Purchases, receives, or otherwise acquires within a twenty-four-hour period any 16 number of packages of any drug product containing any detectable amount of ephedrine, 17 levomethamphetamine, phenylpropanolamine, propylhexedrine, or pseudoephedrine, or any EXPLANATION — Matter enclosed in bold-faced brackets [thus] in the above bill is not enacted and is intended to be omitted from the law. -
Powerpoint Slides
Welcome to the 2021 IDS Forensic Science Education Series • Do today: Attorneys – if you would like CLE credit, report your attendance to me using the link that I email you and I will submit your information to the bar. The State Bar will invoice you for $3.50 per hour of CLE credit at the end of the credit year. 60 min of general CLE credit is anticipated. You may only receive credit for attending the live (not recorded) version of the webinar. • Do later: For participants who complete 10 or more webinars in this year’s series and report their credit to me, you’ll receive acknowledgement that you completed this course of forensic education. For this certificate, watching the recorded version is fine. Please report this attendance to me in Dec. 2021. • I will email you the link to report your attendance to me. • Questions? Email [email protected] Edward G. Brown, Ph.D. NC Indigent Defense Services CLE April 1, 2021 Edward G. Brown, Ph.D. Dr. Brown obtained his Bachelor of Science degree in Chemistry from U.C. Berkeley in 1980 and his Doctoral degree in Organic Chemistry from U.C. Davis in 1988. Two post- doctoral chemistry research fellowships from University of Auckland, New Zealand, and Yale University furthered his academic studies in medicinal chemistry and analytical chemistry techniques through 1990. Dr. Brown’s productivity during his career as a medicinal and organic chemistry researcher in academics and while working at several pharmaceutical companies and other laboratories has led to his co-inventorship on ten US patents and his co- authorship on over thirty research articles and conference presentations. -
Screening/Spot Test of Narcotics
Indian Journal of Forensic and Community Medicine 2020;7(4):160–165 Content available at: https://www.ipinnovative.com/open-access-journals Indian Journal of Forensic and Community Medicine Journal homepage: https://www.ipinnovative.com/journals/IJFCM Review Article Screening/spot test of narcotics A K Jaiswal1,*, Kamna Sharma2, Rohit Kanojia3, Sally Lukose4 1Dept. of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India 2Galgotias University, Greater Noida, Uttar Pradesh, India 3Dept. of Chemistry, University of Delhi, New Delhi, India 4CTM-IRTE, Faridabad, Haryana, India ARTICLEINFO ABSTRACT Article history: Narcotics are the substances used to treat moderate to severe pain. They could be natural like opiates such Received 25-11-2020 as morphine, codeine etc., synthetic like fentanyl, methadone etc., and semi-synthetic like oxycodone, Accepted 02-12-2020 hydrocodone etc. These drugs act as pain relievers, induces the state of stupor or sleep, and increase Available online 08-01-2021 the physical dependence on them. In forensic autopsy case, the forensic pathologist may require a complete toxicological investigation for different poisons including stimulants. In India, Forensic Science Laboratories run by Government under the Home ministry usually carry out this. The samples must be Keywords: analysed by the forensic toxicologist/chemists/scientist. This article deals with the screening/spot test for Narcotics narcotics. It attempts to simplify the standard procedures in a step-wise manner, which can be of handy Screening reference for the forensic toxicologist. Spot test Drugs © This is an open access article distributed under the terms of the Creative Commons Attribution Opioids etc License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. -
The Stimulants and Hallucinogens Under Consideration: a Brief Overview of Their Chemistry and Pharmacology
Drug and Alcohol Dependence, 17 (1986) 107-118 107 Elsevier Scientific Publishers Ireland Ltd. THE STIMULANTS AND HALLUCINOGENS UNDER CONSIDERATION: A BRIEF OVERVIEW OF THEIR CHEMISTRY AND PHARMACOLOGY LOUIS S. HARRIS Dcparlmcnl of Pharmacology, Medical College of Virginia, Virginia Commonwealth Unwersity, Richmond, VA 23298 (U.S.A.) SUMMARY The substances under review are a heterogenous set of compounds from a pharmacological point of view, though many have a common phenylethyl- amine structure. Variations in structure lead to marked changes in potency and characteristic action. The introductory material presented here is meant to provide a set of chemical and pharmacological highlights of the 28 substances under con- sideration. The most commonly used names or INN names, Chemical Abstract (CA) names and numbers, and elemental formulae are provided in the accompanying figures. This provides both some basic information on the substances and a starting point for the more detailed information that follows in the individual papers by contributors to the symposium. Key words: Stimulants, their chemistry and pharmacology - Hallucinogens, their chemistry and pharmacology INTRODUCTION Cathine (Fig. 1) is one of the active principles of khat (Catha edulis). The structure has two asymmetric centers and exists as two geometric isomers, each of which has been resolved into its optical isomers. In the plant it exists as d-nor-pseudoephedrine. It is a typical sympathomimetic amine with a strong component of amphetamine-like activity. The racemic mixture is known generically in this country and others as phenylpropanolamine (dl- norephedrine). It is widely available as an over-the-counter (OTC) anti- appetite agent and nasal decongestant. -
Drug Chemistry Procedure Manual 1
Drug Chemistry Procedure Manual 1 SECTION A: Preliminary Tests Marquis Reagent ..................................................................................................... A - 1 Duquenois-Levine Reagent .................................................................................... A - 2 Cobalt Thiocyanate Reagent .................................................................................. A - 3 Ferric Chloride Reagent ......................................................................................... A - 4 Koppanyi Reagent................................................................................................... A - 5 Potassium Permanganate Reagent ...................................................................... A - 6 p-Dimethylaminobenzaldehyde Reagent (PDMAB) .............................................. A - 7 Froehde’s Reagent.................................................................................................. A - 8 Mecke’s Reagent..................................................................................................... A - 9 Silver Nitrate Reagent............................................................................................. A - 10 Zwikker Reagent...................................................................................................... A - 11 Barium Chloride Reagent ....................................................................................... A - 12 Methanolic Potassium Hydroxide Reagent ......................................................... -
Pseudoephedrine Smurfing Fuels Surge in Large-Scale
ARCHIVED LIMITED OFFICIAL USE-LAW ENFORCEMENT SENSITIVE//FOR OFFICIAL USE ONLY U.S. Department of Justice National Drug Intelligence Center June 2009 Situation Report Product No. 2009-S0787-007 Pseudoephedrine Smurfing Fuels Surge in Large-Scale Methamphetamine Production in California Preface This Situation Report is in response to a request from the Office of National Drug Control Policy for information regarding pseudoephedrine smurfing in California. The National Drug Intelligence Center collected and analyzed data and reporting from 2007 through May 2009 related to metham- phetamine production and pseudoephedrine smurfing. This report draws upon data from the National Seizure System (NSS) as well as information obtained through interviews with federal, state, and local law enforcement officers. Executive Summary Pseudoephedrine smurfinga has become increasingly organized and widespread in California, par- ticularly since 2007, fueling an increase in the number of large-scale methamphetamine laboratories in the state.1 Among the increased number of large-scale laboratories are those operated by Mexican criminal groups that have relocated to California from Mexico since 2007. Mexican criminal groups and some independent operators are increasingly acquiring bulk quantities of pseudoephedrine through smurfing. Despite strong efforts by law enforcement to curtail smurfing, there is no indication that this practice will decline in the near term. In fact, pseudoephedrine acquired through smurfing in California in 2009 was sent in bulk to methamphetamine producers in Mexico, an indication that some criminal groups in Mexico still find it easier to acquire pseudoephedrine through smurfing in California than from other sources. Discussion Pseudoephedrine smurfing increased significantly in California in 2008 and early 2009. -
Methamphetamine Manufactured from Pseudoephedrine; Both As Double
2019 Methamphetamine Manufactured from Pseudoephedrine; Both as Double- Edged Swords Fanak Fahimi* *Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Received: 2019-12-20, Revised: 2019-12-21, Accept: 2019-12-22, Published: 2019-12-31 A R T I C L E I N F O Article type: Editorial J Pharm Care 2019; 7(4):80-81. Please cite this paper as: Fahimi F. Methamphetamine Manufactured from Pseudoephedrine; Both as Double-Edged Swords. J Pharm Care 2019; 7(4): 80-81. Methamphetamine, or meth, is a potent stimulant that meth. The regulation was effective from September 2006 is prescribed for psychiatric conditions such as attention (8). So, by law the following were required: deficit hyperactivity disorder (ADHD) and weight issues. All pseudoephedrine containing OTC medicines should Contrariwise, this agent is more used recreationally for be sold from behind a sales counter and limits of 3.6 energy boosting and feelings of strength it creates. grams per day or 9 grams per 30 days. The medicine is Pseudoephedrine (PSE) is the key ingredient used to only sold to patient who presents a formal identification produce methamphetamine. Pseudoephedrine has one card and provide personal information which will be kept less hydroxyl group compared to another commonly used in the pharmacy for 2 years. sympathomimetic in cold and allergy products which Meth lab numbers dropped by more than 65% in 2007 results in a more lipid soluble molecule and thus more following this law. Sadly, meth lab events remained high or central nervous system (CNS) availability (1). -
INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report
INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report SEIZED MATERIALS 2015/1 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3 NPS reported by ICE participants Page 4 Codes and Abbreviations Page 7 Sample 1 Analysis Page 8 Identified substances Page 8 Statement of findings Page 12 Identification methods Page 21 Summary Page 26 Z-Scores Page 27 Sample 2 Analysis Page 31 Identified substances Page 31 Statement of findings Page 35 Identification methods Page 44 Summary Page 49 Z-Scores Page 50 Sample 3 Analysis Page 53 Identified substances Page 53 Statement of findings Page 55 Identification methods Page 60 Summary Page 65 Sample 4 Analysis Page 66 Identified substances Page 66 Statement of findings Page 71 Identification methods Page 80 Summary Page 85 Z-Scores Page 86 Full test Samples Information Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 5.2 % (w/w) cocaine base. The test sample also contained glucose, caffeine, lidocaine, procaine and trace amounts of creatine and levamisole. Sample 2 SM-2 was prepared from a seizure containing 5.5 % (w/w) amfetamine base. The test sample also contained caffeine and creatine. Sample 3 SM-3 was a blank test sample containing no substances from the ICE menu. Sample 4 SM-4 was prepared from a seizure containing 72.2%(w/w) heroin base. the seizure also contained acetylcodeine, -
For Peer Review 19 Studies
Drug Testing and Analysis A review of chemical ‘spot’ tests: a presumptive illicit drug identification technique Journal:For Drug Peer Testing and Analysis Review Manuscript ID DTA-17-0289.R1 Wiley - Manuscript type: Review Date Submitted by the Author: n/a Complete List of Authors: Philp, Morgan; University of Technology Sydney, Centre for Forensic Science Fu, Shanlin; University of Technology Sydney, Centre for Forensic Science presumptive identification, color test, new psychoactive substances, Keywords: chemistry Chemical ‘spot’ tests are a presumptive illicit drug identification technique commonly used by law enforcement, border security personnel, and forensic laboratories. The simplicity, low cost and rapid results afforded by these tests make them particularly attractive for presumptive identification globally. In this paper, we review the development of these long- established methods and discuss color test recommendations and guidelines. A search of the scientific literature revealed the chemical Abstract: reactions occurring in many color tests are either not actively investigated or reported as unknown. Today, color tests face many challenges, from the appearance of new psychoactive substances to concerns regarding selectivity, sensitivity, and safety. Advances in technology have seen color test reagents used in digital image color analysis, solid sensors and microfluidic devices for illicit drug detection. This review aims to summarize current research and suggest the future of presumptive color testing. http://mc.manuscriptcentral.com/dta Page 1 of 34 Drug Testing and Analysis 1 2 3 A review of chemical ‘spot’ tests: a presumptive illicit drug identification 4 5 technique 6 7 Morgan Philp and Shanlin Fu 8 9 10 11 Short title: Review of chemical spot tests for illicit drug detection 12 13 Chemical ‘spot’ tests are a presumptive illicit drug identification technique commonly used 14 by law enforcement, border security personnel, and forensic laboratories. -
Recommended Methods for the Identification and Analysis Of
Vienna International Centre, P.O. Box 500, 1400 Vienna, Austria Tel: (+43-1) 26060-0, Fax: (+43-1) 26060-5866, www.unodc.org RECOMMENDED METHODS FOR THE IDENTIFICATION AND ANALYSIS OF AMPHETAMINE, METHAMPHETAMINE AND THEIR RING-SUBSTITUTED ANALOGUES IN SEIZED MATERIALS (revised and updated) MANUAL FOR USE BY NATIONAL DRUG TESTING LABORATORIES Laboratory and Scientific Section United Nations Office on Drugs and Crime Vienna RECOMMENDED METHODS FOR THE IDENTIFICATION AND ANALYSIS OF AMPHETAMINE, METHAMPHETAMINE AND THEIR RING-SUBSTITUTED ANALOGUES IN SEIZED MATERIALS (revised and updated) MANUAL FOR USE BY NATIONAL DRUG TESTING LABORATORIES UNITED NATIONS New York, 2006 Note Mention of company names and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. ST/NAR/34 UNITED NATIONS PUBLICATION Sales No. E.06.XI.1 ISBN 92-1-148208-9 Acknowledgements UNODC’s Laboratory and Scientific Section wishes to express its thanks to the experts who participated in the Consultative Meeting on “The Review of Methods for the Identification and Analysis of Amphetamine-type Stimulants (ATS) and Their Ring-substituted Analogues in Seized Material” for their contribution to the contents of this manual. Ms. Rosa Alis Rodríguez, Laboratorio de Drogas y Sanidad de Baleares, Palma de Mallorca, Spain Dr. Hans Bergkvist, SKL—National Laboratory of Forensic Science, Linköping, Sweden Ms. Warank Boonchuay, Division of Narcotics Analysis, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand Dr. Rainer Dahlenburg, Bundeskriminalamt/KT34, Wiesbaden, Germany Mr. Adrian V. Kemmenoe, The Forensic Science Service, Birmingham Laboratory, Birmingham, United Kingdom Dr. Tohru Kishi, National Research Institute of Police Science, Chiba, Japan Dr. -
1This Action Arises Under the Patent Laws of the United States. See 35 U.S.C
IN THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF PENNSYLVANIA MCNEIL-PPC, INC., : Plaintiff, : CIVIL ACTION : v. : : L. PERRIGO COMPANY, : and PERRIGO COMPANY, : No. 01-1100 Defendants. : OPINION AND ORDER SCHILLER, J. June , 2002 This is a patent infringement action. Plaintiff McNeil-PPC, Inc. (“McNeil”) alleges Defendants L. Perrigo Company and Perrigo Company (collectively “Perrigo”) infringe four McNeil patents covering a popular version of the Imodium® Advanced antidiarrheal. In a Memorandum and Order issued April 3, 2002, I construed certain disputed claim terms pursuant to Markman v. Westview Instruments, Inc. , 517 U.S. 370 (1996). Beginning April 22, 2002, this matter was tried without a jury, and I enter the following Findings of Fact and Conclusions of Law as required by Rule 52(a) of the Federal Rules of Civil Procedure. 1 FINDINGS OF FACT I. BACKGROUND This action pits a manufacturer of national brand pharmaceuticals against its competitor, a generic drug manufacturer. Four patents owned by Plaintiff McNeil are at issue in this case: United States Patents 5,248,505 (“the ’505 patent”)(PTX1) and 5,612,054 (“the ’054 patent”)(PTX2) are 1This action arises under the patent laws of the United States. See 35 U.S.C. § 271(e)(2) and 21 U.S.C. § 355(j). Jurisdiction is based on 28 U.S.C. §§ 1331 and 1338(a). Venue is proper in this Court pursuant to 28 U.S.C. §§ 1391(c) and 1400(b). referred to as “the Garwin patents”; 2 United States Patents 5,679,376 (“the ’376 patent”)(PTX3) and 5,716,641 (“the ’641 patent”)(PTX4) are referred to as “the Stevens patents.” A. -
Seized Drugs Technical Manual
Seized Drugs Technical Manual Approval Date: 06/12/2019 Document Number: 4561 Approved By: David Gouldthorpe, David Johnson, Cassandra Robertson Revision Number: 12 Date Published: 06/12/2019 Las Vegas Metropolitan Police Department Forensic Laboratory 5605 W. Badura Ave. Ste. 120B Las Vegas, NV 89118 Seized Drugs Technical Manual ARCHIVED Uncontrolled Copy if not located in Qualtrax Page 1 of 167 Seized Drugs Technical Manual Approval Date: 06/12/2019 Document Number: 4561 Approved By: David Gouldthorpe, David Johnson, Cassandra Robertson Revision Number: 12 Date Published: 06/12/2019 Table of Contents Chapter Title Introduction ANALYTICAL TECHNIQUES 1.1 Color Tests 1.2 Chromatography 1.3 Mass Spectrometry (MS) 1.4 Infrared Spectroscopy (IR) 1.5 X-Ray Fluorescence (XRF) 1.6 Raman Spectroscopy QUALITY CONTROL 2.1 Reference Materials and Supplies 2.2 Reference Material Inventory Audit 2.3 Color Test Reagent Quality Control 2.4 Quality Control Plan SEIZED DRUG ANALYSIS 3.1 Seized Drugs Analysis Quality Control 3.2 Sampling 3.3 Identification Criteria 3.4 Evidence Discrepancies and Preliminary Field Test Errors 3.5 Marijuana Analysis 3.6 Opium Analysis 3.7 Analysis of Fentanyl and Fentanyl Related Substances CLANDESTINE LABORATORIES 4.1 Clandestine Laboratory Response 4.2 ARCHIVEDClandestine Laboratory Analysis REPORTING AND TECHNICAL REVIEW 5.1 Reporting 5.2 Technical Review 6 Retraining 7 Recipes and Derivatizing Agents PROCEDURES 8.1 Logging Reference Materials into LIMS Uncontrolled Copy if not located in Qualtrax Page 2 of 167 Seized