( 12 ) United States Patent
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US009833513B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 ,833 ,513 B2 Larson et al. (45 ) Date of Patent: Dec . 5 , 2017 ( 54 ) LIQUID PROTEIN FORMULATIONS FOR CO7K 16 /241 ( 2013 .01 ) ; CO7K 16 / 2839 INJECTION COMPRISING ( 2013 . 01 ) ; COZK 16 /2863 (2013 .01 ) ; COOK 1 -BUTYL - 3 -METHYLIMIDAZOLIUM 16 / 2887 ( 2013 .01 ) ; CO7K 16 / 32 ( 2013 . 01 ) ; METHANESULFONATE AND USES A61K 38/ 00 ( 2013 .01 ) THEREOF (58 ) Field of Classification Search ( 71 ) Applicant : EAGLE BIOLOGICS , INC ., None Woodcliff Lake, NJ (US ) See application file for complete search history . (72 ) Inventors: Alyssa M . Larson , Dana Point, CA (US ) ; Kevin Love, Boston , MA (US ) ; (56 ) References Cited Alisha K . Weight, Mill Creek , WA (US ) ; Alan Crane , Waban , MA (US ) ; U . S . PATENT DOCUMENTS Robert S . Langer, Newton , MA (US ) ; 3 ,682 , 174 A 8 / 1972 Cohen Alexander M . Klibanov, Boston , MA 4 ,092 ,410 A 5 / 1978 Ogata et al . 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Pure Appl . Chem ., 72 ( 7 ) : 1391 - 8 ( 2000 ) . A61K 39 /395 ( 2006 .01 ) (Continued ) A61K 47 /06 ( 2006 .01 ) A61K 47 / 24 ( 2006 .01 ) A61K 9 /00 ( 2006 .01 ) Primary Examiner — Yunsoo Kim A61K 47 / 20 ( 2006 . 01 ) ( 74 ) Attorney , Agent, or Firm — Baker & Hostetler LLP A61K 47 / 22 ( 2006 . 01 ) CO7K 16 /22 ( 2006 .01 ) COOK 16 / 24 ( 2006 . 01 ) (57 ) ABSTRACT COZK 16 / 28 ( 2006 . 01 ) A61K 47 / 18 ( 2017 .01 ) Concentrated , low - viscosity , low - volume liquid pharmaceu A61K 9 / 19 ( 2006 .01 ) tical formulations of proteins have been developed . Such CO7K 16 /32 ( 2006 . 01 ) formulations can be rapidly and conveniently administered A61K 38 /00 ( 2006 .01 ) by subcutaneous or intramuscular injection , rather than by (52 ) U . S . CI. lengthy intravenous infusion . These formulations include CPC . .. A61K 47 / 06 ( 2013 .01 ) ; A61K 9 / 0019 low -molecular -weight and / or high -molecular - weight pro (2013 .01 ) ; A61K 9 / 19 (2013 .01 ) ; A61K teins , such as mAbs, and viscosity - reducing ionic liquids. 39 / 3955 ( 2013 .01 ) ; A61K 47/ 186 ( 2013 .01 ) ; A61K 47/ 20 (2013 . 01) ; A61K 47 / 22 (2013 . 01) ; A61K 47 / 24 ( 2013 .01 ) ; C07K 16 / 22 ( 2013 .01 ) ; 26 Claims, No Drawings US 9 ,833 Page, 513 2 B2 (56 ) References Cited 2016 /0074515 Al 3 /2016 Soane et al . 2016 /0090419 Al 3 / 2016 Morichika et al. U . S . PATENT DOCUMENTS 2016 /0193346 A17 / 2016 Houston et al . 2016 /0367675 Al 12 /2016 Liu et al. 5 , 773 ,571 A 6 / 1998 Nielsen et al. 2017 /0049888 AL 2 /2017 Liu et al. 5 , 779 ,668 A 7 / 1998 Grabenkort 5 , 786 , 571 A 7 / 1998 Bethel et al. FOREIGN PATENT DOCUMENTS 5 ,819 , 988 A 10 / 1998 Sawhney et al. 5 . 871, 736 A 2 / 1999 Bruegger et al . EP 2538973 1 / 2013 5 , 962 ,405 A 10 / 1999 Seelich wo W00244321 A2 6 / 2002 6 ,065 ,645 A 5 /2000 Sawhney et al . 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