Winter/Spring 2020

Forewords from the Head

Dear DoCS:

 Faculty & Staff Updates This has been a remarkable  Awards/Congratulations year, but with the changes  Grants in how meetings are run,  Books, Papers and has given me the Accomplishments opportunity to see how  In the News Departmental meetings  Postdoc, Graduate Student work at the cabinet, group & Resident News and individual level.  Who Am I Hopefully, that will make the  Other News and Updates transition easier. At this point, it seems as if we are going to have to get used to the new zoom-dominated environment for a long time to come. I want to thank the faculty, staff, house officers, and graduate students for all of their efforts to keep teaching and clinical commitments going. I realize this has been an immense effort, and I am grateful for everyone’s team spirit. Hopefully, we can all learn new teaching techniques that will become a part of how we approach students in the future. I have realized more than ever what a remarkable department DoCS is, and I am proud to have been selected to lead us forward.

I want to particularly thank Lizette for all of her guidance over the transition. Fortunately for all of us, she will remain at NC State, and will continue on as co-Assistant Department Head (with Greg Lewbart) within the MSM group. I am in the process of moving into the Department office, so if you are in the CVM, please feel free to drop by for an impromptu socially-distanced meeting!

Best wishes to everyone as new challenges approach in the upcoming Fall semester

--Anthony ______

Faculty & Staff Updates

New Employees  Dr. Mariea Ross-Estrada started on December 19, 2019 as an Assistant Clinical Professor of Small Animal General Practice.

1  Dr. Diane Deresienski started on December 30, 2019 as an Associate Clinical Professor of Small Animal General Practice.  Dr. Alix Berglund moved into a Research Scholar position on January 1, 2020.  Dr. Nicholas de Castro started on January 10, 2020 as a Research Associate in Dr. Duncan Lascelles Lab.  Dr. Yu Ueda started on February 3, 2020 as an Assistant Clinical Professor of Emergency and Critical Care.  Dr. LaTisha Knight started on March 2, 2020 as an Assistant Clinical Professor of Ophthalmology.  Dr. Katarzyna Dembek started on March 31 2020 as an Assistant Professor of Equine Internal Medicine.  Dr. Allison Kendall started on June 1, 2020 as an Assistant Clinical Professor of Small Animal Internal Medicine.

Departing Faculty and Staff  Beth Lubeck – December 7, 2019  Dr. Freya Mowat – December 31, 2019  Dr. Caitlin O’Shea – January 16, 2020

Faculty Recruitment Updates  Dr. Jose Len has been hired as an Assistant Professor of Theriogenology. He will start in 2020.  Dr. Sarah Ozawa will start on August 31, 2020 as an Assistant Clinical Professor of Avian-Exotic Medicine.  Dr. Annie Oh will start on August 31, 2020 as an Assistant Clinical Professor of Ophthalmology.  We are in the process of recruiting for a faculty position in Dentistry and Oral Surgery, and hope to re-open searches for faculty positions in Dermatology, Cardiology, and Equine Orthopedics. The latter searches were closed earlier this year due to Covid-19 restrictions. ______

Awards/Congratulations was promoted to Research (December 2019 – May 2020) Dr. Ricardo Maggi Professor effective July 1, 2020. Dr. Anthony Blikslager received the AVMA Dr. Steve Marks received the Huffman Clinical Research Award, American Veterinary th Medical Association in Schaumburg, IL. May Leadership Award at the 36 Annual CVM 2020. Awards Ceremony.

Dr. Laura Nelson received the Class of 2021 Dr. Dianne Dunning was promoted to Clinical th Professor effective July 1, 2020. CVM Faculty Award at the 36 Annual CVM Awards Ceremony. Dr. Lizette Hardie received the AAVC Faculty Award. Dr. Thierry Olivry was awarded the European College of Veterinary Dermatology (ECVD) Dr. Karyn Harrell received the Class of 2020 Lifetime Career Award. This award is given CVM Faculty Award at the 36th Annual CVM every four years to a senior ECVD diplomate Awards Ceremony. who has made major scholarly, scientific, educational or political contributions to Dr. Kate Meurs has been named Senior veterinary dermatology in Europe and the Associate Dean and Director for Research and World. Graduate Studies. The new addition to her title - “Senior” - is in recognition of her nearly 10 Dr. Barbara Qurollo was promoted to years of service to the college, and the Associate Research Professor effective July 1, extensive additional responsibilities she has 2020. taken on in the past few years.

2 Dr. Lauren Schnabel was awarded the NCSU pain in Sled Dogs, and determine its use as a 2020 Zoetis Award for Veterinary Research prognostic marker. $4,000. Excellence at the 36th Annual CVM Awards Ceremony. Gruen ME (PI), Lascelles BDX (Co-I). Do dog breeds differ in pain sensitivity? Separating fact Dr. Amy Snyder was promoted to Associate from perception. We will test the assumption Clinical Professor effective July 1, 2020. that dog breeds differ in sensitivity. We will achieve this primarily through QST applied to Dr. Sarah Townsend became a diplomate of various breeds, and concurrently gather ‘omic the American College of Veterinary Surgeons- and microbiome data to help understand Small Animal. differences we find. We will also test this ______assumption through an analysis of clinical data on pain scores and analgesic use across Grants Received different breeds. $104,147.

(December 2019 – May 2020) Lascelles BDX (PI). A pilot multi-center, Chiu KW, Duffy DJ (PI), Chang YC, Fisher masked, randomized clinical field study to MB. Description of novel locking tenorrhaphy evaluate the effectiveness and safety of patterns for canine flexor tendon repair. resiniferatoxin (rtx) compared to a sham Investigator Grant for research for $12,000 injection for the control of pain associated with awarded at Veterinary Orthopedic Society osteoarthritis. This is pilot work to assess our conference in Sun Valley, Idaho, February capability in performing a larger clinical trial. 2020. Duffy: Mentor, Lead Investigator, $16,751. Corresponding author. Lascelles BDX (PI). Prevalence of Harms C. Temporary threshold shifts in hearing osteoarthritis in young dogs and response to in aquatic turtles. Prime: US Navy-ONR; Direct: treatment. We will determine the prevalence of Woods Hole Oceanographic Institution. 2020- the disease of osteoarthritis in dogs less than 4 21. $12,677. years old, and also determine the prevalence of pain associated with this. $508,230. Harrison TM (Co-I). NIH supplement. Characterization of elephant tumor evolution. Mishra SK, Olivry T - Co-PI. Investigations on 2019; $20,014. the role of the indoor environmental stressor house dust mite in atopic dermatitis. NCSU Harrison TM (Co-PI). TriCEM, A cross species Center for Human Health and the Environment, analysis of the mutational landscape of cancer. Raleigh, North Carolina. 2020-2021; $25,000. 2020; $7,000. Schnabel LV - PI, Messenger K – Co-I. Lascelles BDX (PI). A wearable sensor study Grayson-Jockey Club Research Foundation, to measure response of a therapeutic food in Inc. “Enhancing the efficacy of MSCs for tendon overweight adult dogs with osteoarthritis. healing.” 2020-2022; $100,686. We will assess the benefit of a therapeutic food in terms of minimizing the signs of osteoarthritis Schnabel LV - PI, Gilbertie J – CO-I. NIH pain in dogs, and concurrently develop (NIAID) STTR with Direct Sponsor Synoxa algorithms for the detection of osteoarthritis Sciences, Inc (Pierce). “Development of natural pain using high-frequency longitudinal product inspired adjuvants to treat tolerant accelerometry data acquisition. $315,094. infections.” 2020-2022; $235,266. ______Lascelles BDX (PI). Investigating artemin: a potential diagnostic marker for osteoarthritis Abstracts, Books, Papers associated joint pain in sled dogs. We will evaluate the role of artemin in osteoarthritis Published and Accomplishments

3 (December 2019 – May 2020) 10.1016/j.domaniend.2020.106470. Epub 2020 Mar 6. PMID: 32408050 Krüger L, Pridgen TA, Taylor ER, Garman ES, Blikslager AT. Lubiprostone protects Duffy DJ, (PI) Curcillo CP, Chang YJ, Gaffney esophageal mucosal from acid injury in porcine L, Fisher MB, Moore GE. Biomechanical esophagus. Am J Physiol Gastrointest Liver evaluation of an autologous flexor digitorum Physol 2020;3218:G613-G623. lateralis graft to augment the surgical repair of gastrocnemius tendon laceration in a canine ex Plundrich NJ, Smith AR, Borst LB, Snider DB, vivo model [published online ahead of print, Kaeser T, Dellon ES, Blikslager AT, Odle J, 2020 Jun 14]. Vet Surg. Lila MA, Laster SM. Oesophageal eosinophilia 2020;10.1111/vsu.13453. accompanies food allergy to hen egg white doi:10.1111/vsu.13453. protein in young pigs. Clin Exp Allergy. 2020;50:95-104. Duffy DJ, (PI) Moore GE. Influence of Blikslager AT, Mair TS. Trends in the oversewing the transverse staple line during management of horses referred for evaluation functional end-to-end stapled intestinal of colic: 2004-2017. Equine Vet Educ, Epub anastomoses in dogs [published online ahead ahead of print, 2020. of print, 2020 Jun 5]. Vet Surg. 2020;10.1111/vsu.13451. Jin Y, Blikslager AT. The regulation of doi:10.1111/vsu.13451. intestinal mucosal barrier by myosin light chain kinase/rho kinases. Int J Mol Sci. Duffy DJ, (PI) Chang YJ, Balko JA, Moore GE. 2020;21:E3550. Effect of presurgical storage conditions on leakage pressures of enterotomy sites closed Slifer ZM, Blikslager AT. The integral role of with unidirectional barbed suture material in tight junction proteins in the repair of injured fresh, chilled, and frozen-thawed cadaveric intestinal epithelium. Int J Mol Sci canine jejunal specimens. Am J Vet Res. 2020;21:E972. 2020;81(3):220-226.

Caston SC. Sponseller BA, Dembek KA, Duffy DJ, (PI) Chang YJ, Moore GE. Influence Hostetter JM. Evaluation of locally injected of closure technique on leakage pressures in an Mycobacterium cell wall fraction in horses with ex vivo canine typhlectomy model [published sarcoids. J Equine Vet Sci . 2020 online ahead of print, 2020 Apr 7]. Vet Surg. Jul;90:103102. doi: 2020;10.1111/vsu.13405. 10.1016/j.jevs.2020.103102. Epub 2020 Apr 22. doi:10.1111/vsu.13405. PMID: 32534762 DOI: 10.1016/j.jevs.2020.10310 Duffy DJ*, (PI) Cocca CJ*, Kersh ME, Moore GE. Influence of Interlocking Horizontal Müller V, Toribio RE, Dembek K, Moraes BSS, Mattress Epitendinous Suture Placement on Mousquer MA, Curcio BR, Nogueira CEW. Tendinous Biomechanical Properties in a Serum cortisol and thyroid hormone Canine Common Calcaneal Laceration Model. concentrations and survival in foals born from Vet Comp Orthop Traumatol. 2020;33(3):205- mares with experimentally induced ascending 211. doi:10.1055/s-0040-1702141 *Indicates placentitis. J Vet Intern Med. 2020 Equal Authorship. May;34(3):1332-1338. doi: 10.1111/jvim.15758. Epub 2020 Apr 27. PMID: 32339347 Chu KL, Duffy DJ, (PI) Vieson MD, Moore GE. Ex vivo comparison of leakage pressures and Kamr AM, Dembek KA, Gilsenan W, leakage location with a novel technique for Bozorgmanesh R, Hassan HY, Rosol TJ, creation of functional side-to-side canine small Toribio RE. C-terminal telopeptide of type I intestinal anastomoses [published online ahead collagen, osteocalcin, alkaline phosphatase, of print, 2020 Apr 7]. Vet Surg. and parathyroid hormone in healthy and 2020;10.1111/vsu.13408. hospitalized foals. Domest Anim Endocrinol. doi:10.1111/vsu.13408. 2020 Jul;72:106470. doi: 4 Duffy DJ, (PI) Chang YJ, Balko JA, Moore GE. Spense J, Dekaney C, Buchon N, and Ex vivo comparison of the effect of storage Sethupathy P. Enteroendocrine progenitor cell temperature on canine intestinal leakage enriched microRNA-7 is a rheostat of Xiap and pressures. Vet Surg. 2020;49(3):496-501. intestinal epithelial proliferation. Cellular and doi:10.1111/vsu.13339. Molecular Gastroenterology and Hepatology 2020;9(3):447-464. PMID: 31756561. Duffy DJ (PI), Curcillo C, Chang YJ, Moore GE. Effect of core suture size on the biomechanical Wahltinez SJ, Newton AL, Harms CA, Lahner properties of flexor tendon repairs in a canine LL, Stacy NI. 2020. Coelomic fluid evaluation in cadaveric model. Accepted Am J Vet Res. 2019 Pisaster ochraceus affected by Sea Star Manuscript ID AJVR-19-10-0169. Wasting Syndrome: evidence of osmodysregulation, calcium homeostasis Chang YJ, Duffy DJ (PI), Gaffney LS, Fisher derangement, and coelomocyte responses. MB, Moore GE. Use of a novel staple device for Front Vet Sci 7: 313, doi: extra-tendinous augmentation of a primary core 10.3389/fvets.2020.00131. tendon repair in an ex-vivo canine flexor tendon laceration model. Accepted Am J Vet Res. 2019 Minter LJ, Ange-van Heugten K, Harms CA, Manuscript ID AJVR-19-10-0171.R1. Stoskopf MK. 2020. Digestible energy intake and digestive efficiency of human managed Maxwell E, Duffy DJ, Dugat D, Walten B, North American river otters (Lontra Spector D, Petrovsky B, Payton M. Outcomes canadensis). Vet Med Int 2020, Article ID of dogs undergoing immediate or delayed 4307456, 7 pp, surgical treatment for gastrointestinal foreign https://doi.org/10.1155/2020/4307456. body obstruction: A Retrospective Study by the Society of Veterinary Soft Tissue Surgery. Niemuth JN, Harms CA, Macdonald JM, Accepted Veterinary Surgery. 2019 Manuscript Stoskopf MK. 2020. NMR-based metabolomic ID is VSU-19-208.R3. profile of cold stun syndrome in loggerhead Carreta carreta, green Chelonia mydas, and Duffy DJ (PI), Chang YJ, Fisher MB, Moore Kemp’s ridley Lepidochelys kempii sea turtles in GE. Effect of partial vs complete circumferential North Carolina, USA. Wildl Biol 2020: epitendinous suture placement on the wlb.00587, doi: 10.2981/wlb.00587. biomechanical properties and gap formation of canine cadaveric tendons. Accepted Veterinary Scott G, Law M, Christiansen EF, Lewbart GA, Surgery. Manuscript ID is VSU-20-123.R2. Harms CA. 2020. Evaluation of localized inflammatory reactions secondary to Gonzalez LM*, Baker WT, Hughes FE, intramuscular injections of enrofloxacin in Blikslager AT, Fogle CA. Histomorphometric striped bass (Morone saxatilis). J Zoo Wildl Comparison of Dorsal Colon and Pelvic Flexure Med 51: 46-52. Biopsies in Equine Large Colon Volvulus Cases that Underwent Resection. American Journal of Lively MJ, Westermeyer HD, Harms CA, Veterinary Research 2020 (accepted). Christiansen EF. 2019. Ophthalmic lesions in a population of cold-stunned sea turtles (Chelonia Orr KE, Baker WT, Lynch TM, Hughes FE, mydas, Lepidochelys kempii, Caretta caretta). Clark CK, Slone DE, Fogle CA, Gonzalez LM. Vet Ophthal 22: 910-915. DOI: Prognostic Value of Colonic and Peripheral 10.1111/vop.12672. Venous Lactate Measurements in Horses with Large Colon Volvulus. Veterinary Surgery 2020 Hopewell E, Harrison SH, Posey R, Duke L, Apr;49(3):474-479. doi:10.0000/vsu.13361. Troan B, Harrison TM. Analysis of published PMID: 31916608. amphibian neoplasia case reports. 2020. Journal of Herpetological Medicine and Singh A, Hung Y, Shanahan M, Kanke M, Surgery. In press. Bonfini A, Dame M, Biraud M, Pek B, Oyesola O, Freund J, Cuitt R, Curry E, Gonzalez L, Hepps Keeney CM, Intile JL, Simms C, Bewick G, Tait-Wojno E, Kurios N, Ding S, Harrison TM. Lymphoid leukemia in five 5 bearded dragons (Pogona vitticeps). 2020. Early Evidence From Naturally Occurring JAVMA. In press. Osteoarthritis-Associated Chronic Pain in Dogs. Front. Neurosci., 13 February 2020. Kedrowicz AA, Royal K. (In Press). A https://doi.org/10.3389/fnins.2020.00077 comparison of public perceptions of physicians and veterinarians. Veterinary Sciences. Nolan MW, Kelsey KL, Enomoto M, Hongyu R, Geiger TL, Lascelles BDX. Pet dogs with McCool KE, Kedrowicz AA. (In Press). subclinical acute radiodermatitis experience Evaluation of veterinary students’ widespread sensitization. Radiation Research, communication skills with a service dog handler 2020 Mar;193(3):241-248. PMID: 31877255. in a simulated client scenario. Journal of Veterinary Medical Education. Eskander BS, Barbar M, Evans RB, Enomoto M, Lascelles BDX, Conzemius M. Translation Kedrowicz AA, Taylor J. (2019). Ideologies of of Activity Monitoring in Normal Dogs Towards Gender: Culture Clash Between the Disciplines Distance Traveled. Can J Vet Res. 2020 In M. Mathison (Ed.), Sojourning in Disciplinary Jan;84(1):44-51. PMID: 31920217. Cultures: A Case Study of Teaching Writing in Engineering. Logan, UT: University Press of Williams MD, Lascelles BDX. Early Neonatal Colorado. Pain—A Review of clinical and experimental implications on painful conditions later in life. Coleman AE, DeFrancesco TC, Lascelles Frontiers in Pediatrics, 07 February 2020. BDX, Kleisch DJ, Sauer J, Griffith EH, Atkins https://doi.org/10.3389/fped.2020.00030. CE, Keene BW. Atenolol in cats with subclinical hypertrophic cardiomyopathy: A double-blind, Steagall PVM, Benito J, Monteiro B, Lascelles placebo-controlled, randomized clinical trial of D, Kronen PW, Murrell JC, Robertson S, Wright effect on quality of life, activity, and cardiac B, Yamashita K. Intraperitoneal and incisional biomarkers. Journal of Veterinary Cardiology. analgesia in small animals: simple, cost- Accepted, April 2020. effective techniques. J Small Anim Pract. J Small Anim Pract. 2020 Jan;61(1):19-23. doi: Risselada M, Tuohy J, Law M, Lascelles BDX. 10.1111/jsap.13084. Epub 2019 Nov 18. Local administration of carboplatin in poloxamer Review. PMID: 31737915. 407 after an ulnar osteosarcoma removal in a dog. Accepted, JAAHA, April 2019. Womble MA, Lewbart GA, Shive HR. 2020. Pathological lesions of the Budgett’s Frog Enomoto M, Lascelles BDX, Gruen ME. (Lepidobatrachus laevis), an emerging Development of a checklist for the detection of laboratory animal model. Comparative Medicine degenerative joint disease-associated pain in doi.org/10.30802/AALAS-CM-19-000071 cats. J Feline Med Surg. 2020 Mar 3:1098612X20907424. doi: Cerreta AJ, Houck EL, Stowe DM, Lewbart 10.1177/1098612X20907424. [Epub ahead of GA. 2020. Hematology of the keeled box turtle print] PMID: 32122226. (Cuora mouhotii). Veterinary Clinical Pathology DOI: 10.1111/vcp.12857 Nolan MW, Green NA, DiVito EM, Lascelles BDX, Haney SM. Impact of radiation dose and Veilleux J, Dombrowski D, Allender M, Lewbart pre-treatment pain levels on survival in dogs GA. 2020. Diagnosis, treatment, and post- undergoing radiotherapy with or without release monitoring of an eastern black rat chemotherapy for presumed extremity snake (Pantherophis alleghaniensis) with osteosarcoma. Vet Comp Oncol. 2020 Feb 11. ophidiomycosis and traumatic injuries. Vet Rec doi: 10.1111/vco.12576. [Epub ahead of print] Case Rep. doi:10.1136/vetreccr-2019-000954 PMID: 32048435. Baja A, Lewbart GA, Luff J, Nolan M. 2020. Minemma L, Wheeler J, Pitake S, Enomoto M, Unexpected but transient tumor enlargement Mishra S, Lascelles BDX. Correlation of preceded complete regression and long-term Artemin and GFRα3 With Osteoarthritis Pain: control after irradiation of squamous cell 6 carcinoma in a red-eared slider (Trachemys Syndromic surveillance of the burden scripta elegans). Vet Rec Case Rep. brachycephalic dogs on ICU resources. J Vet doi:10.1136/vetreccr-2019-000954. Emerg Crit Care 2019;31(S1): S2

Beachler TM, Gracz HS, Morgan DR, Olivry T, Mueller RS. Critically appraised topic Bembenek-Bailey SA, Borst L, Ellis K, Von on adverse food reactions of companion Dollen KA, Lyle SK, Nebel A, Andrews NC, animals (9): Time to flare of cutaneous signs Koipalli J, Gadsby JE, Bailey CS. Plasma after a dietary challenge in dogs and cats with metabolomic profiling of healthy pregnant food allergies. BMC Veterinary Research 2020; mares and mares with experimentally induced 16:158. PMID: 32448251. DOI: placentitis. First published: 18 March 2020 10.1186/s12917-020-02379-3. https://doi.org/10.1111/evj.13262 High EJ, Olivry T. Development and validation Rossi G, Stachel A, Lynch AM, Olby NJ. of a graphic two-dimensional investigator’s Intervertebral disc disease and aortic global assessment instrument for grading the thromboembolism are the most common overall severity of atopic dermatitis in dogs. causes of acute paralysis in dogs and cats Veterinary Dermatology 2020; 31: 207-e43. presenting to an emergency clinic. [published PMID: 31833143. DOI: 10.1111/vde.12824. online ahead of print, 2020 May 29]. Vet Rec. (Corresponding author with resident trainee first 2020;vetrec-2019-105844. author).

Pavlides S, Lynch AM, Snowden K, Leissenger Favrot C, Fischer N, Olivry T, Zwickl L, M. Evaluation of an emergency medicine- Audergon S, Rostaher A. Atopic dermatitis in focused clinical pathology training course for West Highland white terriers - Part I: natural non-clinical pathology house officers. J Vet history of atopic dermatitis in the first three Emerg Crit Care 2020;30(2):165‐169. years of life. Veterinary Dermatology 2020; doi:10.1111/vec.12938. 31:106-110. PMID: 31646697. DOI: 10.1111/vde.12801. Granick M, Lynch AM, Cohen E. Extrahepatic biliary tract obstruction secondary to a Mishra SK, Wheeler J, Pitake S, Ding H, Jiang diaphragmatic rent in a dog. Vet Record Case C, Fukuyama T, Paps JS, Ralph P, Coyne J, Reports 2020;8(2): e001060. Parkington M, DeBrecht J, Ehrhardt-Humbert LC, Cruse GP, Bäumer W, Ji RR, Ko MC, DiDomenico AE, Stowe DM, Lynch AM. What Olivry T. Periostin activation of integrin is your diagnosis? Abdominal fluid from a dog. receptors on sensory neurons induces allergic Vet Clin Path 2020;49(1):164-166 itch. Cell Reports 2020; 31: 107472. PMID: 32268102; DOI: 10.1016/j.celrep.2020.03.036. Davy R, Campos S, Lynch AM. Acute chlorfenapyr toxicity in 3 dogs from a single Cugmas B, Olivry T, Olivrī A, Spīgulis J. household. J Vet Emerg Crit Care 2019; Skimager for the objective erythema estimation 29(6):686-689. in atopic dogs. Proceedings Photonics in Dermatology and Plastic Surgery (SPIE BioS) Campos S, Allen-Durrance AE, Lynch AM, 2020, 1121110. DOI: 10.1117/12.2544664. Schaer M. Retrospective evaluation of Micrurus fulvius (Eastern coral snake) envenomation and Leeb T, Leuthard F, Jagannathan V, Kiener S, the use of mechanical ventilation in dogs and a Letko A, Roosje P, Welle MM, Gailbreath KL , cat: 8 cases (2011-2016). J Vet Emerg Crit Cannon AG, Linek, M, Banovic F, Olivry T, Care 2019; 29(6): 662-667 White SD, Batcher K, Bannasch D, Minor KM, Mickelson JR, Hytönen MK, Lohi H, Mauldin Barchard-Couts A, Brainard B, Buckley G, Daly EA, Casal ML. A missense variant affecting the M, Kursch L, Heinz J, Londono L, Lynch A, C-terminal tail of UNC93B1 in dogs with Mazzaferro E, Rozanski E, Rudloff E, Rutter C, exfoliative cutaneous lupus erythematosus. Sharp C, Siegel N, Silverstein D, Wayne A. The Genes 2020; 11: 159. PMID: 32028618; DOI: Brachycephalic Summer Study Group. 10.3390/genes11020159. 7 High EJ, Olivry T. The prevalence of bacterial pneumothorax: 110 cases (2009-2019). infections during ciclosporin therapy in dogs: A Accepted to JAVMA 5/11/20. critically appraised topic. Canadian Veterinary Journal, accepted, May 2020. (Corresponding Diamond D, Scharf VF*, Chiu KW, Hash JA, author with resident trainee first author). Mathews KG. Evaluation of fixed- versus variable-angle endoscopy for exploratory Smith CM, Olivry T, Lawhon SD, Rodrigues- thoracoscopy in canine cadavers. Accepted to Hoffman A. Malassezia species dysbiosis in Vet Surg 5/2/20. natural and allergen-induced atopic dermatitis in dogs. Medical Mycology. ePub ahead of Patel NJ, Scharf VF*, Brady R. Single-incision print, December 2019. PMID: 31782778. DOI: laparoscopic decortication and omentalization 10.1093/mmy/myz118. of a cystic renal adenoma in a dog. Accepted to JAAHA 5/4/20. Von Fricken ME, Qurollo BA, Boldbaatar B, Wang YW, Jiang RR, Lkhagvatseren S, Koehler Scharf VF*, Oblak ML, Hoffman K, Skinner OT, JW, Moore TC, Nymadawa P, Anderson BD, Neal KM, Cocca CJ, Duffy DJ, Wallace ML. Matulis G, Jiang JF, Gray GC. Genetic diversity Clinical features and outcome of functional of Anaplasma and Ehrlichia bacteria found in thyroid tumors in 70 dogs. Accepted to JSAP Dermacentor and Ixodes ticks in Mongolia. 5/20/20. Ticks and Tick Borne Dis. 2020 Jan;11(1):101316. Scharf VF*, Milovancev M, Townsend K, Luff J. Use of a bipolar sealing device to seal partial Qurollo BA, Stillman BA, Beall MJ, Foster P, cystectomy with and without augmentation with Hegarty BC, Breitschwerdt EB, a single-layer simple continuous suture pattern Chandrashekar R. Comparison of Anaplasma in an ex vivo canine model. Accepted to Vet and Ehrlichia species-specific peptide ELISA Surg in March 2020 (already available online). assays to immunofluorescent assays for serological diagnosis of canine anaplasmosis Cheng K, Tang J, Su T, Qiao L, Huang K, and ehrlichiosis. 2020 In Press AJVR. Wrona E, Shen D, Liang H, Mathews K, Scharf V, Freytes D. An off-the-shelf artificial cardiac Tyrrell JD, Qurollo BA, Mowat FM, Kennedy- patch improves cardiac repair after myocardial Stoskopf S. Molecular Prevalence of Selected infarction in rats and pigs. Accepted to Sci Vector-Borne Organisms in Captive Red Transl Med in March 2020. Wolves (Canis rufus). 2020 in press JZWM. Chambers A, Skinner O, Mickelson M, Schlag Ernst E, Qurollo B, Olech C, Breitschwerdt E. A, Butler RJ, Wallace M, Moyer A, Vinayak A, Bartonella rochalimae, a Newly Recognized Samuel N, Kennedy K, Oakes K, Scharf V, Pathogen in Dogs. 2020. Accepted for Parker L, Wustefeld-Janssens B. Adherence to publication JVIM follow-up recommendations for dogs with anal https://doi.org/10.1111/jvim.15793 sac adenocarcinoma: a multicenter retrospective study. Accepted to VCO in March Dickson R, Scharf VF*, Nelson N, Petrovich N, 2020. Keenihan E, Mathews K. The effect of patient positioning during computed tomography on Dinh PC, Paudel D, Brochu H, Cores J, Huang identification of pulmonary bullae associated K, Hensely MT, Harrell E, Vandergriff AC, with spontaneous pneumothorax in dogs: 15 Barrio R, Allen TA, Blackburn K, Caranasos cases (2013-2019). Vet Radiol Ultrasoun. TG, Peng X, Schnabel LV, Adler KB, Lobo LJ, Accepted 6/2/2020. Goshe M, Cheng K. Inhalation of Lung Spheroid Cell Secretome and Exosomes Dickson R, Scharf VF*, Michael AE, Walker M, Promotes Lung Repair in Models of Pulmonary Thomson C, Grimes J, Singh A, Oblak M, Fibrosis. Nature Communications 2020 Feb Brisson B, Case JB. Surgical management and 28;11(1):1064. doi: 10.1038/s41467-020- outcome of dogs with primary spontaneous 14344-7.

8 Gilbertie JM, Schaer TP, Schubert AG, Jacob Meet Dr. Sarah Townsend! ME, Menegatti S, Lavoie RA, Schnabel LV. ______Platelet-rich plasma lysate displays anti-biofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro. J Orthop Staff, Post-doc, Graduate Res 2020 Jun;38(6):1365-1374. doi: Student & Resident News 10.1002/jor.24584. Epub 2020 Jan 14. Dr. Alix Berglund Research Connection Walker KK, Pusey AE. 2020. Inbreeding risk and maternal support have opposite effects on Dr. Alix Berglund was recently recognized by female chimpanzee dispersal. Current Biology, the NIH with a Mentored Research Scientist 30(2), R62-R63. Career Development Award (K Award) for her ______work on understanding immune aspects of stem cell therapy using the horse as a model.

In the News Research Connection Dr. Adam Eby

Rhinos continue to be poached for their horns , (Mentor) – Winner of the Mark at alarming rates. Groundbreaking anatomical Eby A Duffy DJ Bloomberg Resident Research Award to research in South Africa from Drs. Mat Gerard, present at the Veterinary Orthopedic Society Anthony Blikslager and students Dina conference in Sun Valley, Idaho, February Ibrahim, Haley Dodson and Kelsie Dougherty, 2020. For work entitled “Influence of barbed will help many survive. epitendinous suture placement in combination

with a core locking loop suture for flexor tendon Dr. Anthony Blikslager offered insight on the repair in a canine cadaveric laceration model.” different types of equine colic.

Carrie Emke was nominated for the 2020 CVM Researchers including Drs. Ed Breitschwerdt Award for Excellence. and Erin Lashnits found a high amount of Bartonella bacteria in tumors and tissues in of the received dogs with hemangiosarcoma. John Freund Gonzalez Lab the 2020 CVM Award for Excellence for

efficiency and innovation. Dr. Diane Deresienski set the record straight with WRAL about flea and tick medication risks. 3rd year resident received the Dr. Endya High Peter J. Ihrke Resident Research Award for Dr. Jody Gookin discussed canine gallbladder Clinical Sciences following her resident mucoceles, an increasingly common and research project presentation at the 2019 North potentially deadly disease, with the Morris American Veterinary Dermatology Forum in Animal Foundation. April 2019. Publication title: Development and

validation of a graphic 2D investigator's global Dr. Margaret Gruen spoke with Woman’s Day assessment instrument for grading the overall about the complexities of canine intelligence. severity of atopic dermatitis in dogs.

Dr. Tara Harrison and her team Research successfully defended her Connection Dr. Laura Minemma PhD thesis (The role of GFRα3/artemin in

chronic osteoarthritis-associated pain) in March A new CVM study led by Dr. April Kedrowicz 2020. shows the positive results of team training DVM students during surgery. and Drs. Pradeep Neupane Ed Breitschwerdt Research Connection The World Small Animal Veterinary Association launches a scholarship for those dedicated to Dr. Pradeep Neupane was recently awarded veterinary pain management, said Dr. Duncan an AKC-CHF Fellowship for his work in Dr. Ed Lascelles. Breitschwerdt’s lab on Immunodiagnotics. 9 Dr. Jennifer Niemuth, PhD student, was selected as the winner of the 2019 WDA- Personal News

IAAAM joint award for the best student- authored aquatic animal paper published in the Journal of Wildlife Diseases for her paper Sea Turtle Tears: A Novel, Minimally Invasive Sampling Method for 1H-NMR Metabolomics Investigations with Cold Stun Syndrome as a Case Example.

Dr. Jennifer Niemuth successfully completed her PhD and also passed the ACZM boards.

Ophthalmology resident, Dr. Annie Oh, received the Best Clinical Manuscript Award at the American College of Veterinary Ophthalmologists Conference.

Andrea Thomson of the Lascelles Lab received the 2020 CVM Award for Excellence for customer service. Dr. Early’s daughter, Zoe, graduated from the Dr. Morika Williams successfully defended her University of Pennsylvania as a 4-year scholar PhD thesis (Long-Term Effects of Neonatal athlete. She has already started her MPH Pain on Chronically Painful Conditions) in program there this summer. February 2020 under the direction of Dr. Duncan Lascelles. His son, Kobe, graduated from Cary High School as their most highly decorated wrestler Dr. Morika Williams accepted a position at ever. His career record was 198-1. He was a UNC Chapel Hill in the Division of Comparative 3X State Champ and 4X State Finalist. He was Medicine as a Clinical Fellow, which she started a 2X National High School All-American. He April 1, 2020. graduated with a 4.21 GPA and will be attending Appalachian State University this fall. Dr. Morika Williams was interviewed for a newsletter entitled "Systemic Change in STEM Faculty": https://provost.ncsu.edu/news/2020/06/systemi c-change-in-stem-faculty/ ______

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Brittany Thomas of the Vector Borne welcomed baby Brewer David Disease Lab Thomas (7lb, 8oz) on December 17th, 2019. His Drs. Chris and Kara Walker welcomed their twin 4 year-old sisters are thrilled to finally have baby boy, Reed Gregory Walker (7lb, 6oz) on a little brother. December 27, 2019!

Who Am I

Dr. Katarzyna Dembek, Assistant Professor of Equine Internal Medicine Dr. Katarzyna Dembek received her Doctor of Veterinary Medicine (DVM) degree from Warsaw University (Poland) in 2005. She completed a one year equine internship at Lisadell Equine Hospital (Ireland). Then she moved to Saudi Arabia for 3 years where she worked in private equine practice as a general practitioner. In 2012, Dr. Dembek completed a combined Equine Internal Medicine Residency and Master of Science training program at The Ohio State University. The same year Dr. Dembek began a PhD training program in equine endocrinology at OSU. In 2016, Dr. Dembek moved to Iowa where she worked as an assistant professor in Equine Medicine at Iowa State University until joining the equine medicine team at NCSU in 2020.

Dr. Diane Deresienski, Associate Clinical Professor of Small Animal General Practice Dr. Diane Deresienski (Dr. D.) received her B.S. from Boston College and her VMD from the University Of Pennsylvania School Of Veterinary Medicine. Dr. D. practiced for 3 years in a Florida mixed- animal practice in Florida prior to joining Dr. Bowman at the Bowman Animal Hospital in 1993, where she practices for nearly 27 years. Dr. D. has always had an interest in wildlife conservation and was a founding board member of the Piedmont Wildlife Center in Durham, NC.

In 2000, Dr. D. became a specialist in Canine and Feline Practice through the American Board of Veterinary Practitioners. Dr. D. enjoys surgery, and has been trained in Juvenile Pubic Symphysiodesis, a surgery to help prevent hip dysplasia in dogs. In 2007, she received

11 her PennHip Certification, qualifying her to perform the unique radiographic testing method that can identify dogs at risk for hip dysplasia.

She is thrilled to be a faculty member in the General Practice service and looks forward to getting to know her new friends and colleagues in the department!

When not working, Dr. D. enjoys yoga, getting away to the coast, international travel, flipping houses, and her season tickets to the North Carolina Ballet.

Dr. LaTisha Knight, Assistant Clinical Professor of Ophthalmology Dr. Knight pursued her undergraduate studies at the University of Florida, then completed a veterinary degree at Purdue University in 2011. She spent a year at Iowa State University completing a small animal rotating internship then returned to Purdue to complete her residency in comparative Ophthalmology in July 2015. Concurrent with her residency, Dr. Knight completed a Master’s of Science degree exploring the use of high frequency ultrasound for detection of uveal cysts in dogs. Since graduating Dr. Knight has worked in private practice, first in Nashville, TN then in Wilmington, NC. During her spare time, Dr. Knight enjoys visiting her family and traveling to unique places. She loves trying new foods or cuisine.

Dr. Mariea Ross-Estrada, Assistant Clinical Professor of Small Animal General Practice Dr. Ross-Estrada received her undergraduate degree from Ohio Wesleyan University in 2002 and her veterinary degree from Cornell University in 2006. Following graduation, she moved to Northern Virginia, where she worked in private practice until she joined the general practice service at NCSU in December 2019. Outside of work, Dr. Ross-Estrada enjoys cooking, reading, traveling, and spending time with her family which includes her daughter, dog (Frijoles Negros), red eared slider (Apollo) and friends.

Dr. Yu Ueda, Assistant Clinical Professor of Emergency and Critical Care Dr. Ueda received his undergraduate degree from Colorado State University and veterinary degree from Washington State University. Following graduation, he completed a one year small animal rotating internship at Auburn University followed by a residency in small animal emergency and critical care at the University of California-Davis. He achieved board certification in small animal emergency and critical care in 2015. He then stayed at the University of California-Davis as a PhD student while working as a staff veterinarian at the teaching hospital. In 2020, he completed his PhD program and joined the small animal emergency and critical care team at NC State.

Outside of work, Dr. Ueda enjoys watching sports, running, traveling, and spending time with friends, family, and his wife, two kids, and his dog.

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12 Other News and Updates

Chancellor Randy Woodson visited TAU and the hospital in April to highlight the great work that was still happening on campus in the midst of COVID-19.

The Class of 2019 gave back to the SimLab that gave so much to them!

30 years ago, the CVM changed the way zoological medicine was practiced and taught. Today, we remain an unmatched force in the field.

When a 6-week-old rescued kitten was brought to the hospital, she had severe trauma to her hind legs. Thanks for our orthopedic surgery team, she can walk again! And she has a new home.

Semper Fi-Do: A Marine K-9’s journey from serious injury to remarkable recovery.

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Justine Tillerson, Newsletter Editor Next Issue: Summer/Fall 2020

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