47Th Annual Meeting PROGRAM

47th Annual Meeti ng of the German Society for Immunology

CELEBRATING

12–15 September 2017 l ERLANGEN PROGRAM

www.immunology-conference.de SAVE THE DATE

2019 II Joint Annual Meeting of the

German Society for Immunology (DGfl) and the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)

10–13 SEPTEMBER 2019 l MUNICH

Friedrich-Alexander University Erlangen-Nürnberg (Erlangen/DE)

German Society for Immunology (DGfI)

German Research Foundati on (DFG)

DFG Research Training Group GRK1660 “Key Signals of Adapti ve Immune Response” (Erlangen/DE)

DFG Clinical Resarch Unit KFO 257 “Molecular Pathogenesis and Opti mised Therapy of Inﬂ ammatory Bowel Diseases” (Erlangen/DE)

Medical Immunology Campus Erlangen (MICE) (Erlangen/DE)

Collaborati ve Research Center CRC (SFB) 1181 “Checkpoints for Resoluti on of Inﬂ ammati on” (Erlangen/DE)

DFG Integrated Research Training Group GRK-SFB1181 “Checkpoints for Resoluti on of Inﬂ ammati on” (Erlangen/DE)

Collaborati ve Research Center SFB769 “Reprogramming of Host Cells by Microbial Eﬀ ectors” (Erlangen/DE)

Collaborati ve Research Center TRR130 “B cells – Immunity and Autoimmunity” (Erlangen/DE)

DFG Integrated Research Training Group IRTG-TRR130 “B cells and Beyond”

University Hospital Erlangen (Erlangen/DE)

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Organizati on and Imprint ...... 5

Welcome Note of the Congress President ...... 6

Invitati on to the General Assembly of the DGfI...... 7

Assemblies & Press Conference ...... 8

Program Overview Tuesday, 12 September...... 10 Wednesday, 13 September ...... 11 Thursday, 14 September ...... 12 Friday, 15 September ...... 13

Scienti ﬁ c Program Tuesday, 12 September...... 14 Wednesday, 13 September ...... 22 Thursday, 14 September ...... 34 Friday, 15 September ...... 46

Poster Sessions ...... 54 Wednesday, 13 September ...... 56 Thursday, 14 September ...... 78 Friday, 15 September ...... 94

General Informati on ...... 100

General Hints for Authors and Presenters ...... 104

Sponsors ...... 107

Exhibitors ...... 108

Plan of Exhibiti on and Posters ...... 110

Social Program ...... 112

Index of Chairs, Invited Speakers and presenti ng Abstract Authors ...... 113

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Venue and Date Heinrich-Lades-Halle Rathausplatz 1 • 91052 Erlangen (DE) 12–15 September 2017

Congress Website www.immunology-conference.de

Scienti ﬁ c Organizer German Society for Immunology (DGfI) www.dgﬁ .org

Congress President Prof. Dr. rer. nat. Hans-Marti n Jäck Division of Molecular Immunology University Hospital Erlangen Friedrich-Alexander University Erlangen-Nürnberg Erlangen (DE)

Honorary Congress Presidents Prof. Dr. med. Dr. h.c.mult. Joachim Kalden (Erlangen/DE) Prof. Dr. med. Marti n Röllinghoﬀ (Erlangen/DE)

Conference Organizati on and Industrial Exhibiti on Conventus Congressmanagement & Marketi ng GmbH Nadia Al-Hamadi, Claudia Ibold Carl-Pulfrich-Strasse 1 • 07745 Jena (DE) Phone +49 3641 31 16 315 • Fax +49 3641 31 16 243 [email protected] • www.conventus.de

Design/Layout Layout krea.ti f-studio UG (limited liability) Print siblog – Gesellschaft für Dialogmarketi ng, Fulﬁ llment & Lett ershop mbH Circulati on 1.200 Editorial deadline 30 August 2017

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Dear colleagues and friends,

On behalf of the board of the German Society for Immunology (DGfI), we are delighted to invite you to parti cipate in our 47th Annual Meeti ng to be held in Erlangen from 12–15 September 2017. The Huguenot town of Erlangen, a modern baroque city, where ancient charm meets innovati ve ideas, is in the heart of the Nürnberg Metropolitan Region. Erlan- gen hosts one of the oldest and most charming outdoor beer festi vals and is home to the Friedrich-Alexander University (FAU) Erlangen-Nürnberg and high-tech ventures such as Siemens Healthineers, the Fraunhofer Insti tute for Integrated Circuits (known for its inven- ti on of the MP3), and the Max Planck Insti tute for the Science of Light. Erlangen with a long traditi on in basic and clinical immunology has developed under former DGfI presidents, Joachim Kalden and Marti n Röllinghoff , into an internati onally recognized research center. More than 50 groups in 13 independent clinics and departments at the University Hospital Erlangen and the Friedrich-Alexander University Erlangen-Nürnberg are part of the interdisciplinary research center “Medical Immunology Campus Erlangen” (MICE). The extramural funding from the Deutsche Forschungsgemeinschaft (DFG) in the fi eld of immunology and infecti ous disease ranks number 2 in Germany and includes 5 collaborati ve research groups focusing on B cells (TRR 130), resoluti on of infl ammati on (SFB 1181), microbial eff ectors (SFB 796), infl ammatory bowel diseases (KFO 257), and osteoimmunology (SPP 1468). Additi onally, there are 3 doctoral training groups with research topics in adapti ve immune responses (GRK-1660), B cells (GRK-TRR 130), and infl ammati on (GRK-SFB 1181). The 47th Annual Meeti ng will be held at the Heinrich-Lades-Halle located in the center of Erlangen just a few minutes from the main railway stati on, hotels, and restaurants. The highlight of the 2017 meeti ng will be the celebrati on of the 50th birthday of our society. To salute this special occasion, the organizing committ ee has compiled an exciti ng scienti fi c program highlighti ng current research topics in basic and translati onal immunology in plenary sessions, main symposia, and workshops. The exhibiti on “The Birth of Immunol- ogy” and a Festschrift will commemorate the history of our society and the highlights of Immunology in Germany. We will fi nish with an unforgett able birthday party on the last evening of the congress. We cordially invite everyone to join us in Erlangen for this exciti ng event. All Erlanger immunologists are looking forward to welcoming you to our city with the charm of a small baroque town. We hope to make this special meeti ng a memorable event!

Sincerely yours,

Hans-Marti n Jäck l Congress President 6 I��

Thursday, 14 September, 19:00–20:45 • Kleiner Saal

Dear members of the German Society for Immunology,

On behalf of the DGfI board we invite you to our 2017 General members’ assembly. The following topics are on the agenda:

TOP 1 Approval of the agenda TOP 2 Approval of the minutes of the last general assembly of 28 September 2016 (see www.dgﬁ .org, members’ area) TOP 3 Report of the secretary general 1. Member stati sti cs 2. DGfI travel grants 3. Homepage 4. Financial report (annual accounts 2016) TOP 4 Discharge of the board TOP 5 New DGfI panels (DGfI Senators and DGfI young immunologists) TOP 6 Animal experimentati on in biomedical research/ Acti viti es of DGfI study groups TOP 7 New journal published by the DGfI – Trillium Immunologie TOP 8 Additi onal qualiﬁ cati on Immunology TOP 9 Bilateral meeti ngs/Guest symposia (AAI/Australia/Argenti na/China/Japan) TOP 10 Internati onal umbrella organizati ons (EFIS, IUIS) TOP 11 ECI2018 Amsterdam TOP 12 AOB

We look forward to your parti cipati on.

With kind regards, Prof. Dr. Michael Lohoﬀ l President DGfI

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Tuesday, 12 September Deutsche Gesellschaft für Immunologie (Hrsg.) 12:30–13:30 Assembly of DGfI Research Focus Group (AKPI): Pediatric Immunology Immunologie in Room Konferenz 1+2 Deutschland Geschichte einer Wissenschaft und Wednesday, 13 September ihrer Fachgesellschaft

10:30–11:15 Assembly of DGfI Research Focus Group (AKS): Signal Transducti on Room Konferenz 7

12:30–14:30 Assembly of DGfI Research Focus Group (AKVI): Veterinary Immunology Room Konferenz 1+2

14:15–15:15 Press Conference (in German) Room Konferenz 7

Thursday, 14 September

12:30–13:30 Assembly of DGfI Research Focus Group (AKTuI): Tumor Immunology 368 Seiten Room Konferenz 1+2 gebunden, 32,- € 14:00–15:00 Assembly of DGfI Research Focus Group (AKDC): Dendriti c Cells Room Konferenz 1+2 ISBN 978-3-95410-097-2 14:00–15:00 Assembly of DGfI Research Focus Group (AKI): Infecti on Immunology Room Konferenz 7 Das 50-jährige Jubiläum der Deutschen sammenführung nach der Wiederverei- 19:00–20:45 General Assembly of the DGfI Gesellschaft für Immunologie bietet nigung in den Blick genommen, sondern Room Kleiner Saal die einmalige Chance, sowohl die wis- auch der Zeitraum von der Entdeckung Immunologie in Deutschland senschaftlichen Triumphe als auch die und der ersten klinischen Anwendung Entwicklung des Fachs Immuno logie in der Antikörper durch Emil von Behring, der deutschen Forschungslandschaft Shibasaburo¯ Kitasato und Paul Ehrlich von der Vergangenheit bis zur Gegen- über den unglaubliche Niedergang der wart näher zu beleuchten. Immunologie mit dem Exodus hervor- In diesem Sammelband wird nicht nur ragender klinischer Immunologen nach die Entwicklung der immunologischen 1930 bis hin zur Entwicklung der Hybri- Fachgesellschaften in der ehemaligen domtechnik durch Georges Köhler und BRD und DDR nach 1945 und deren Zu- Cesar Milstein im Jahre 1975.

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bebra-Anz_Immunologie_A5.indd 1 28.08.17 11:16 Deutsche Gesellschaft für Immunologie (Hrsg.) Immunologie in Deutschland Geschichte einer Wissenschaft und ihrer Fachgesellschaft

368 Seiten gebunden, 32,- €

ISBN 978-3-95410-097-2

Das 50-jährige Jubiläum der Deutschen sammenführung nach der Wiederverei- Gesellschaft für Immunologie bietet nigung in den Blick genommen, sondern die einmalige Chance, sowohl die wis- auch der Zeitraum von der Entdeckung Immunologie in Deutschland senschaftlichen Triumphe als auch die und der ersten klinischen Anwendung Entwicklung des Fachs Immuno logie in der Antikörper durch Emil von Behring, der deutschen Forschungslandschaft Shibasaburo¯ Kitasato und Paul Ehrlich von der Vergangenheit bis zur Gegen- über den unglaubliche Niedergang der wart näher zu beleuchten. Immunologie mit dem Exodus hervor- In diesem Sammelband wird nicht nur ragender klinischer Immunologen nach die Entwicklung der immunologischen 1930 bis hin zur Entwicklung der Hybri- Fachgesellschaften in der ehemaligen domtechnik durch Georges Köhler und BRD und DDR nach 1945 und deren Zu- Cesar Milstein im Jahre 1975.

www.bebra-wissenschaft.de 9

bebra-Anz_Immunologie_A5.indd 1 28.08.17 11:16 P�� • T��, 12 S��

Großer Saal Kleiner Saal Konferenz 5 Konferenz 3+4 09:00–13:30 08:55–12:05 09:00–12:00 Joint Satellite Guest Symposium Joint Satellite Meeting Symposium AKKI and 09:30–13:30 DGfI‐SAI DGAKI and DGfI AKPI Satellite Symposium AKTuI Challenges in Infection Innate and Adaptive Exploring the Human Medicine Immunity in Immune News and Views of Allergy System Tumor Immunology and Immunotherapies

p. 14 p. 16

p. 15 p. 17

14:30–16:05 Opening Ceremony Welcome to Immunology 2017

p. 18

16:30–18:08 Key Symposium Plenary Session Young Immunologists Main Symposium DGfI Session Workshop Lunch Session p. 19 Poster Session Social Program 18:30–20:15 President’s Symposium with DGfI Awards

p. 19 20:15–21:30 Welcome Reception and Meeting the Industrial Exhibitors p. 20

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Großer Saal Kleiner Saal Konferenz 5 Konferenz 3+4 Konferenz 1+2 08:30–10:30 08:30–10:30 08:30–10:30 08:30–10:30 08:30–10:30 T Cell Plasticity and Onco‐immunology Myeloid Mucosal Responses video feed from Lineage Commitment Differentiation and Konferenz 5: Plasticity Myeloid Differentiation and Plasticity

p. 22 p. 22 p. 23 p. 23 p. 23 10:30–11:00 Industrial Exhibition and Coffee Break 11:00–12:30 11:00–12:30 11:00–12:30 11:00–12:30 11:00–12:30 Infection I Activating Immune Antigen Presentation B Cells I Transplantation Cells against Tumors

p. 24 p. 24 p. 25 p. 26 p. 27 12:30–13:30 12:30–13:30 12:30–15:00 12:30–13:30 12:30–13:30 Career Lunch: Time Takara Bio Europe DFG Funding Miltenyi Biotec Industrial Exhibition Management for GmbH and Lunch Break Immunologists p. 28 p. 27 p. 28 13:30–15:30 Poster Session I Antigen Presentation, B Cells I, Chronic Inflammation & Autoimmunity I Immune Diagnostics and Monitoring, Immunodeficiency, Infection I, p. 28 Innate Receptors and Sensors, Microbiome and Immunity, NK Cells and other Innate Immune Cells I, T Cells I, Transplantation, Tumor Immunology and Immunotherapy I, Vaccination p. 56 15:30–17:00 15:30–17:00 15:30–17:00 15:30–17:00 15:30–17:00 T Cell Development Innate Immune Cells Microbiome and Chronic Vaccination and Effector Function Immunity Inflammation and Autoimmunity I

p. 29 p. 30 p. 30 p. 31 p. 32 17:00–17:30 Coffee Break 17:30–19:00 B Cells

p. 33

20:00–22:00 Young Immunologists Science‐Dating Kitzmann BräuSchänke (Südliche Stadtmauerstr. 25, 91054 Erlangen) within 5 minutes walking distance p. 33

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Großer Saal Kleiner Saal Konferenz 5 Konferenz 3+4 Konferenz 1+2 08:30–10:30 08:30–10:30 08:30–10:30 08:30–10:30 08:30–10:30 Post‐transcrip‐ From Naive to Detection of Damage Inflammatory video feed from tional and post‐ Memory B Cells and and Danger Diseases Konferenz 5: translational Con‐ Plasma Cells Detection of Damage trol in the Immune and Danger System

p. 34 p. 34 p. 35 p. 35 p. 35 10:30–11:00 Industrial Exhibition and Coffee Break 11:00–12:30 11:00–12:30 11:00–12:30 11:00–12:30 11:00–12:30 Infection II Helper Cells and Treg Chronic B Cells II Complement Cells Inflammation and Autoimmunity II

p. 36 p. 37 p. 37 p. 38 p. 39 12:30–13:30 12:30–13:30 12:30–14:00 12:30–13:30 10x Genomics Agilent Technologies Acteria Alumni Lunch Industrial Exhibition Sales & Service GmbH & Session and Lunch Break p. 40 Co. KG p. 40 13:30–15:30 Poster Session II p. 40

B Cells II, Chronic Inflammation and Autoimmunity II, Complement, Dendritic Cells, Infection II, NK Cells and other Innate Immune Cells II, Signaling and transcriptional Regulation in Immune Cells, Tumor Immunology and Immunotherapy II, Veterinary Immunology

p. 78 15:30–17:00 15:30–17:00 15:30–17:00 15:30–17:00 15:30–17:00 Signaling and NK Cells Tumor Evasion Dendritic Cells Veterinary transcriptional Immunology Regulation in Immune Cells p. 41 p. 42 p. 42 p. 43 p. 44 17:00–17:30 Coffee Break 17:30–19:00 Infection

p. 44 19:00–20:45 General Aassembly of the DGfI

p. 44

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Großer Saal Kleiner Saal Konferenz 5 Konferenz 3+4 Konferenz 1+2 08:30–10:30 08:30–10:30 08:30–10:30 08:30–10:30 08:30–10:30 Immune Tolerance Antimicrobial Allergy: Mechanisms Metabolic Control of video feed from Effector Functions and Diagnostics Immune Responses Konferenz 5: Allergy: Mechanisms and Diagnostics

p. 46 p. 46 p. 47 p. 47 p. 47 10:30–11:00 Industrial Exhibition and Coffee Break 11:00–12:30 11:00–12:30 11:00–12:30 11:00–12:30 11:00–12:30 Cytotoxic T Cells Innate Receptors and Allergy and Regulatory Immune Neuroimmunology Sensors Immuno‐ Cells deficiencies

p. 48 p. 48 p. 49 p. 50 p. 51 12:30–13:30 12:30–13:30 12:30–13:30 Industrial Exhibition AYOXXA NanoString Techno‐ and Lunch Break Biosystems GmbH logies Germany GmbH p. 52 p. 52 13:30–16:00 Poster Session III

Allergy, Neuroimmunology, Regulatory Immune Cells , T Cells II

p. 97 16:00–17:00 Award of Poster Prizes p. 53 Key 17:00–18:30 Plenary Session Clinical Immunology Main Symposium DGfI Session Workshop Lunch Session p. 53 Poster Session 18:30–19:00 Social Program Closing Remarks p. 53 from 19:15 Scientific Plenary Debate followed by Social Evening E‐Werk Erlangen (Fuchsenwiese 1, 91054 Erlangen/DE) within 15 minutes walking distance p. 53

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08:55–12:05 Guest Symposium DGfI-SAI • Challenges in Infecti on Medicine Room Konferenz 5 Chairs Tim Sparwasser (Hannover/DE), Virginia Elena Rivero (Córdoba/AR)

08:55 Welcome note Tim Sparwasser (Hannover/DE), Virginia Elena Rivero (Córdoba/AR)

09:00 Eﬀ ector and regulatory pathways involved in the development of CD8+ T cell responses during Trypanosoma cruzi infecti on Eva Acosta Rodriguez (Córdoba/AR)

09:15 Human γδ T cells are quickly reconsti tuted aft er stem cell transplantati on and show adapti ve clonal expansion in response to viral infecti on Immo Prinz (Hannover/DE)

09:30 Trypanosoma cruzi infecti on: role of the Wnt/β-catenin and the Aryl hydrocarbon Receptor (AhR) signaling pathways in the control of parasite replicati on and the development of protecti ve immune response Claudia Cristi na Motran (Córdoba/AR)

09:45 Metabolic reprogramming of myeloid cells during infecti on Luciana Berod (Hannover/DE)

10:00 Functi onal analyses of a novel isoform of Dlg2 expressed diﬀ erenti ally in IFNβ producing plasmacytoid dendriti c cells Stefanie Scheu (Düsseldorf/DE)

10:15–10:45 Coﬀ ee Break

10:45 Development of an oral vaccine platf orm based on protecti ve and adjuvant properti es of surface proteins of the intesti nal parasite Giardia lamblia Hugo D. Luján (Córdoba/AR)

11:00 Krüppel-like factor 2 controls plasma cell homeostasis Wolfgang Schuh (Erlangen/DE)

11:15 Galecti n-3 deﬁ ciency drives lupus-like disease by promoti ng spontaneous germinal centers formati on via IFN-γ Adriana Gruppi (Córdoba/AR)

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11:30 Development of a Shiga toxin neutralizing equine hyperimmune serum for an emergency treatment of infecti ons with Shiga toxin-producing Escherichia coli Ulrich Kalinke (Hannover/DE)

11:45 Pathogenic and regulatory mechanisms underlying male genital tract infecti on with Chlamydia Virginia Elena Rivero (Córdoba/AR)

12:00 Closing remarks Tim Sparwasser (Hannover/DE), Virginia Elena Rivero (Córdoba/AR)

09:00–13:30 Joint Satellite Symposium AKKI & AKPI • Exploring the Human Immune System Room Großer Saal Chairs Tim Niehues (Krefeld/DE), Bimba Hoyer (Berlin/DE)

09:00 From episomal DNA to clinical phenotyping – screening for immunodeﬁ ciency Stephan Borte (Leipzig/DE), Leif Hanitsch (Berlin/DE)

10:00 Multi colour ﬂ ow cytometry and repertoire analysis – T and B cell defects and dysregulati on Christi na Zielinski (Munich/DE), Hanna Ijspeert (Rott erdam/NL)

11:00–11:30 Break

11:30 Telomer length determinati on – telomeropathies Tim Brümmendorf (Aachen/DE), Marcin Wlodarski (Freiburg/DE)

12:30 Closing remarks

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09:00–12:00 Joint Satellite Meeti ng DGAKI & DGfI • Innate and Adapti ve Immunity in Allergy Room Konferenz 3+4 Chairs Niklas Engels (Götti ngen/DE), Wolfgang Pfützner (Marburg/DE)

09:00 Innate and adapti ve mechanisms in regulati on of allergen tolerance Carsten Schmidt-Weber (Munich/DE)

09:25 Factors determining the allergenic acti vity of an anti gen Rudi Valenta (Vienna/AT)

09:50 Innate immune signaling to allergens in the upper airway epithelium Stefanie Gilles (Munich/DE)

10:05 “The good, the bad and the ugly” – how diﬀ erent microbes shape cutaneous immune responses in atopic dermati ti s Thomas Volz (Munich/DE)

10:20 Tissue stress and -damage responses as key players in the development of contact hypersensiti vity reacti ons Philipp Esser (Freiburg/DE)

10:35 Mast cells orchestrate innate and adapti ve responses to contact allergens Anne Dudeck (Magdeburg/DE)

10:50 IL-17 producing cells in pulmonary sensiti zati on Melanie Albrecht (Hannover/DE)

11:05 Control of ROR(γt)+ Treg inducti on is criti cal for intesti nal homeostasis Caspar Ohnmacht (Munich/DE)

11:20 Modulati on of T and B cell responses induced by allergen-speciﬁ c immunotherapy Christi an Möbs (Marburg/DE)

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09:30–13:30 Satellite Symposium AKTuI • News and Views of Tumor Immunology and Immunotherapies Room Kleiner Saal Chairs Diana Dudziak (Erlangen/DE), Jörg Wischhusen (Würzburg/DE)

09:30 Introducti on: news and views of immune escape and immunotherapies Barbara Seliger (Halle/DE)

09:45 MicroRNAs regulati ng the expression of HLA class I anti gen processing components in melanoma Maria-Filothei Lazaridou (Halle/DE)

10:00 Warburg phenotype induces high inﬁ ltrati on of regulatory T cells in human OSCC Katrin Singer (Regensburg/DE)

10:15 Blocking lactate secreti on by simultaneous inhibiti on of MCT1 and MCT4 with diclofenac preserves T cell eﬀ ector functi ons and improves checkpoint therapy Kathrin Renner (Regensburg/DE)

10:30 Tumour ischaemia by interferon-ƴ resembles physiological blood vessel regression Thomas Kammertoens (Berlin/DE)

10:50 A new functi on for Kallikrein as acti vator of chemokine CCL14 Dagmar Quandt (Halle/DE)

11:05–11:30 Coﬀ ee Break

Chairs Marina Kreutz (Regensburg/DE), Michael Bachmann (Dresden/DE)

11:30 In-depth analysis of human ti ssue DCs for bett er cancer vaccine design Diana Dudziak (Erlangen/DE)

11:45 Retargeti ng of human T lymphocytes to EGFR-expressing cancer cells via nanobody-based target modules using the universal chimeric anti gen receptor technology Susann Albert (Dresden/DE)

12:05 Of CARs and TRUCKs: new generati on of CAR T cells Hinrich Abken (Cologne/DE)

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12:20 The costi mulatory domain in chimeric anti gen receptor modiﬁ ed T lymphocytes deﬁ nes their resistance to immunosuppression by regulatory T cells Alexandra Kegler (Dresden/DE)

12:35 Using the novel universal CAR platf orm technology „UNICAR“ to target tumors overexpressing disialoganglioside (GD2) Nicola Mitwasi (Dresden/DE)

12:55 Roadblocks to cancer immunotherapy? Jörg Wischhusen (Würzburg/DE)

14:30–16:05 Opening Ceremony • Welcome to Immunology 2017 Room Großer Saal Chairs Hans-Marti n Jäck (Erlangen/DE), Michael Lohoﬀ (Marburg/DE)

Musical interlude

14:33 Welcome to 50 years DGfI by the Congress President Hans-Marti n Jäck (Erlangen/DE)

14:53 Welcome to Erlangen by the Lord Mayor Florian Janik (Erlangen/DE)

15:00 Welcome to the Friedrich-Alexander University Erlangen-Nürnberg by the Vice President of Educati on FAU Erlangen-Nürnberg Friedrich Paulsen (Erlangen/DE)

15:08 Welcome to Erlangen by the Parliamentary State Secretary for Educati on & Research Stefan Müller (Erlangen/DE)

Musical interlude

15:16 Immunology@Erlangen Christi an Bogdan (Erlangen/DE)

15:30 From anti toxins to monoclonal anti bodies Georg Friedrich Melchers (Berlin/DE)

Musical interlude

16:05–16:30 Coﬀ ee Break

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16:30–18:08 Symposium • Young Immunologists Room Großer Saal Chairs Kirsten Dietze-Schwonberg (Mainz/DE), Marco Cavallari (Freiburg/DE)

16:30 How to publish a paper Cate Livingston (Managing Editor, European Journal of Immunology)

Musical interlude

16:53 Somati c hypermutati on serves two independent functi ons: anti body YI1 maturati on away from binding self and towards binding foreign Deborah Burnett (Darlinghurst/AU)

17:08 Translati onal repression of pre-formed cytokine mRNA prevents chronic YI2 acti vati on of memory T cells Monika Wolkers (Amsterdam/NL)

17:23 Dominant low avidity clonotypes arise from reverse TCR repertoire YI3 evoluti on during chronic CMV infecti on Kilian Schober (Munich/DE)

17:38 Microbiota stably imprint inﬂ ammati on-resistant tolerogenic properti es YI4 within mesenteric lymph node stromal cells during the neonatal phase Mangge Zou (Braunschweig/DE)

17:53 Eﬀ ecti ve Treg therapy of severe acute gastrointesti nal graft -versus-host YI5 disease Christi n Riegel (Regensburg/DE)

18:08–18:30 Break

18:30–20:15 President’s Symposium with DGfI Awards Room Großer Saal Chair Michael Lohoﬀ (Marburg/DE)

Musical interlude

18:33 Welcome by the DGfI President Michael Lohoﬀ (Marburg/DE)

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18:43 Ott o-Westphal Award

18:45 Ott o-Westphal Awardee Award1 CD8 T cells orchestrate pDC - XCR1 DC spati al and functi onal cooperati vity to opti mize priming Anna Brewitz (Bonn/DE)

18:51 Hans-Hench Award

18:53 Hans-Hench Awardee Award2 Characterizati on of IL-17-producing enthesis-resident gd T cells Annika Reinhardt (Hannover/DE)

18:59 Fritz-und-Ursula-Melchers Award

19:01 Fritz-und-Ursula-Melchers Awardee Award3 Human Treg speciﬁ city directs tolerance versus allergy against aeroanti gens Petra Bacher (Berlin/DE)

19:07 Herbert-Fischer Award

19:09 Herbert-Fischer Awardee Award4 Sall1 is a transcripti onal regulator deﬁ ning microglia identi ty and functi on Anne Butt gereit (Zurich/CH)

19:15 Georges-Köhler Award

19:17 Georges-Köhler Awardee Broadly Neutralizing Anti bodies targeti ng HIV-1 Florian Klein (Cologne/DE)

Musical interlude

19:26 Award of Honorary DGfI Memberships

19:42 My years of “Fortschritt ” in immunology – a journey measured in friends, not kilometers Tak Wah Mak (Toronto/CA)

20:15–21:30 Welcome Recepti on and meet the Industrial Exhibitors (see p. 112)

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Acteria Prizes Acteria Alumni Lunch Session 2018 Thursday September 14, 2017 l 12:30–14:00 awarded by EFIS Lecture Room K3+4

Singling out Europe‘s Chances and Challenges of a young talents in Immunology & Allergology

chairs Stefanie Eyerich Dietmar Zehn deadline: Anne Hosmalin December 31, 2017 Topics covered in round table discussion:

• www.acteriaprizes.net • Topics YOU selected:

Lunch VOUCHER

the Acteria Session Box at the DGfI Booth or submit it under www.umfrageonline.com/s/acteria 21 S�� • W��, 13 S��

08:30–10:30 Main Symposium • T Cell Plasti city and Lineage Commitment (sponsored by GRK1660) Room Großer Saal Chairs Jochen Hühn (Braunschweig/DE), Hansjörg Schild (Mainz/DE)

08:30 Follicular regulatory T cells control humoral autoimmunity when NFATc1 overcomes Blimp1-mediated CXCR5 suppression Friederike Berberich-Siebelt (Würzburg/DE)

09:00 Lineage tracing of endogenous hematopoiesis from stem cells Katrin Busch (Heidelberg/DE)

09:30 The role of IRF4 during Th cell diﬀ erenti ati on Michael Lohoﬀ (Marburg/DE)

10:00 Memory T cell diﬀ erenti ati on in acute and chronic infecti ons Dietmar Zehn (Freising/DE)

08:30–10:30 Main Symposium • Onco-immunology (sponsored by MICE Erlangen) Room Kleiner Saal Chairs Andreas Mackensen (Erlangen/DE), Gert Riethmüller (Munich/DE)

08:30 Opti mal choice of T cell subsets and safeguard mechanisms for adopti ve T cell therapy Dirk H. Busch (Munich/DE)

09:00 Myeloid-derived suppressor cells (MDSC) – criti cal cells that link obesity to cancer and drive immune suppression in the tumor microenvironment Suzanne Ostrand-Rosenberg (Balti more, MD/US) (Guest society AAI)

09:30 Dendriti c cell vaccines as a component of personalized cancer therapy Gerold Schuler (Erlangen/DE)

10:00 CAR T cell therapy of cancer Claudia Rössig (Münster/DE)

22 S�� • W��, 13 S��

08:30–10:30 Main Symposium • Myeloid Diﬀ erenti ati on and Plasti city Rooms Konferenz 5, video feed to Konferenz 1+2 Chairs Stefanie Scheu (Düsseldorf/DE), Manfred Lutz (Würzburg/DE)

08:30 On the role of slan-positi ve myeloid cells in cancer Marco A. Cassatella (Verona/IT) (Guest society SIICA)

09:00 Dampening adapti ve immune responses by targeti ng suppressive myeloid cell to lymph nodes Reinhold Förster (Hannover/DE)

09:30 Development and plasti city of plasmacytoid dendriti c cell Anne B. Krug (Planegg-Marti nsried/DE)

10:00 Single cell genomics to bett er understand myeloid diﬀ erenti ati on and p l a s ti c i t y Joachim L. Schultze (Bonn/DE)

08:30–10:30 Main symposium • Mucosal Responses (sponsored by CRC (SFB) 1181) Room Konferenz 3+4 Chairs Ellen D. Renner (Augsburg/DE), David Vöhringer (Erlangen/DE)

08:30 Regulati on of intesti nal immunity through the aryl hydrocarbon receptor repressor Irmgard Förster (Bonn/DE)

09:00 Anti body mediated sterilizing immunity in the strictest sense aft er mucosal viral exposure Klaus Überla (Erlangen/DE)

09:30 Unique regulati on of innate and adapitve lung immunity Manfred Kopf (Schlieren/CH)

10:00 Inﬂ ammatory bowel diseases Markus F. Neurath (Erlangen/DE)

10:30–11:00 Industrial Exhibiti on and Coﬀ ee Break

23 S�� • W��, 13 S��

11:00–12:30 Workshop • Infecti on I Room Großer Saal Chairs Ger van Zandbergen (Langen, Mainz/DE), Clarissa da Costa (Munich/DE)

11:00 Inhibiti on of neutrophil necrosis controls Mycobacterium tuberculosis O14 growth aft er removal by macrophages Tobias Dallenga (Borstel/DE)

11:15 Type I interferon-IL-10 axis curbs anti -infecti on immunity during chronic O15 liver inﬂ ammati on Zeinab Abdullah (Bonn/DE)

11:30 Helminth-induced interference with vaccinati on eﬃ cacy and the role of O16 type 1 regulatory T cells Wiebke Hartmann (Hamburg/DE)

11:45 Systemic modulati on of human anti -fungal Th17 responses by Candida O17 albicans via cross-reacti ve T cells Petra Bacher (Berlin/DE)

12:00 Characterizati on of naturally-acquired anti -glycan anti bodies O18 Tim Rollenske (Heidelberg/DE)

12:15 Hypoxia-induced dormancy in Coxiella burneti i is regulated by the O19 acti vati on status of STAT3 Fabian Fischer (Erlangen/DE)

11:00–12:30 Workshop • Acti vati ng Immune Cells against Tumors Room Kleiner Saal Chairs Barbara Seliger (Halle/DE), Jörg Wischhusen (Würzburg/DE)

11:00 Skin-resident memory T cells and melanoma surveillance O8 Thomas Gebhardt (Melbourne/AU)

11:15 TGF-β enhances the cytotoxic acti vity of Vδ2 T cells O9 Christi an Peters (Kiel/DE)

11:30 RNA-transfecti on of γ/δ T cells with a chimeric anti gen receptor or an O10 α/β T-cell receptor: a safer alternati ve to geneti cally engineered α/β T cells for the immunotherapy of melanoma Niels Schaft (Erlangen/DE)

24 S�� • W��, 13 S��

11:45 Comprehensive approach for identi fying the T-cell subset origin of CD3 O11 and CD28 anti body-acti vated chimeric anti gen receptor-modiﬁ ed T-cells Michael Schmueck-Henneresse (Berlin/DE; Houston, TX/US)

12:00 A novel TLR agonist as a potent anti -cancer therapeuti c agent O12 Jutt a Petschenka (Mainz/DE)

12:15 Combining in situ vaccinati on with immune checkpoint blockade induces O13 long-term regression of lymphoma tumors Linda Hammerich (New York, NY/US)

11:00–12:30 Workshop • Anti gen Presentati on Room Konferenz 5 Chairs Marcus Groett rup (Konstanz/DE), Christi an Kurts (Bonn/DE)

11:00 The immunoproteasome subunit LMP7 is required in the thymus for O26 ﬁ lling up a hole in the T cell repertoire Michael Basler (Konstanz/DE; Kreuzlingen/CH)

11:15 The distributi on of C-type lecti n receptors in the dendriti c cell membrane O27 Jennifer J. Lühr (Erlangen/DE)

11:30 Orchestrati on of nucleic acid sensing pathways in HSV-speciﬁ c O28 CD8+ T cell priming Annabell Bachem (Melbourne/AU)

11:45 An alternati ve Batf 3-independent cross-presentati on mechanism in the O29 spleen can acti vates cytotoxic T lymphocytes Marika Enders (Bonn/DE)

12:00 Drug-induced, ubiquiti n-dependent degradati on of stable anti gens O30 enhances their direct presentati on on MHC class I molecules Christopher Schliehe (Rott erdam/NL)

12:15 Indirect presentati on of Y-chromosome anti gen Dby is regulated by Hsc70 O31 and mediated through CD63 positi ve exosomes Sascha Kretschmann (Erlangen/DE)

25 S�� • W��, 13 S��

11:00–12:30 Workshop • B Cells I Room Konferenz 3+4 Chairs Marta Rizzi (Freiburg/DE), Dirk Mielenz (Erlangen/DE)

11:00 Binding of WIP to acti n is required for B cell acti n cytoskeleton plasti city, O1 thereby inﬂ uencing migrati on and anti body producti on Selina Keppler (Munich/DE)

11:13 BAFF- and TACI-dependent processing of BAFFR by ADAM proteases O2 regulates the survival of B cells Cristi an Roberto Smulski (Freiburg/DE)

11:26 Deregulati on of PAX5 causes abnormal B cell lymphopoiesis and O3 spontaneous precursor B cell lymphoma development in mice Anselm Enders (Canberra/AU)

11:39 Regulati on of transcripti on factors Foxp1, E2A and Egr-1 by microRNA-191 O4 constrains B lymphocyte development and suppresses development of diﬀ use large B cell lymphoma Marcin Lyszkiewicz (Hannover, Munich/DE)

11:52 MyD88 expression is largely required for the hBtk-mediated increase in O5 cytokine-positi ve splenic B cells Jasper Rip (Rott erdam/NL)

12:05 CD21low B cells: a T-bet positi ve B cell populati on O6 Baerbel Keller (Freiburg/DE)

12:18 The role of Krueppel-like factor 2 in B cell acti vati on and plasma cell O7 homeostasis Wolfgang Schuh (Erlangen/DE)

26 S�� • W��, 13 S��

11:00–12:30 Workshop • Transplantati on Room Konferenz 1+2 Chairs Reinhard Schwinzer (Hannover/DE), Michaela Lucas (Perth/AU)

11:00 Averted NFATc1 sumoylati on in alloreacti ve T cells ameliorates aGVHD O20 Musga Qureischi (Würzburg/DE)

11:15 Graft -versus-host disease (GVHD) preventi on by in vitro-generated O21 myeloid-derived suppressor cells (MDSCs) is preferenti ally mediated by the CD11b+CD11c+Gr-1int subpopulati on Jasmin Scheurer (Ulm/DE)

11:30 Normothermic oxygenated ex vivo lung perfusion signiﬁ cantly reduces O22 ischemia/reperfusion injury in lung recipients by promoti ng cytokine antagonists Christi ne Falk (Hannover, Braunschweig/DE) Ramon Bellmàs Sanz (Hannover/DE)

11:45 CXCR4-SDF1α Blockade reduces the severity of murine heart allograft O23 r e j e c ti o n Jian Fu (Haikou/CN)

12:00 Understanding ti ssue residency in organ transplantati on O24 Michaela Lucas (Perth/AU)

12:15 Maternal: fetal tolerance is disrupted in preeclampti c pregnancies O25 Andrea Loewendorf (Pasadena, CA/US)

12:30–13:30 Lunch Symposium* • Takara Bio Europe Room Kleiner Saal

Proﬁ ling TCR and BCR repertoires with SMARTer NGS technology Sara Gonzalez-Hilarion (St. Germain-en-Laye/FR)

*Lunch will be provided by sponsor. 27 S�� • W��, 13 S��

12:30–13:30 Lunch Symposium* • Miltenyi Biotec GmbH Take your Research to the next Level – new Tools in Immunology Room Konferenz 3+4

12:30 Innovati ons for straightf orward and ﬂ exible magneti c cell separati on: TILs from solid tumors and lymphocytes directly from blood Anne Richter (Bergisch Gladbach/DE)

13:00 Regulati on of ILC2 during ﬁ broinﬂ ammatory and infecti ous diseases Stefan Wirtz (Erlangen/DE)

12:30–13:30 Career Lunch • Time Management for Immunologists Room Großer Saal Organizers Christi an Schütz (Langen/DE), Carsten Krieg (Zurich/CH) Speaker Michael Hübler (Fürth/DE)

I. Setti ng prioriti es • ... between urgent and important • ... between perfecti onism and realism

II. Eﬃ cient workﬂ ows

III. Customized work techniques • ... why plan if things go diﬀ erent? • ... control by task lists • ... organize desk space • ... manage your emails

IV. How to deal with “ti me thiefs”

12:30–15:00 Lunch Seminar • DFG Funding Room Konferenz 5

DFG Funding Opportuniti es Katharina Hartmann (DFG)

12:30–13:30 Industrial Exhibiti on and Lunch Break

*Lunch will be provided by sponsor. 28 S�� • W��, 13 S��

13:30–15:30 Poster Session I Anti gen Presentati on P10–P20 p. 56 B Cells I P22–P43 p. 57 Chronic Inﬂ ammati on & Autoimmunity I P67–P96 p. 58 Immune Diagnosti cs and Monitoring P159–P164 p. 61 Immunodeﬁ ciency P165–P172 p. 61 Infecti on I P173–P206 p. 63 Innate Receptors and Sensors P237–P249 p. 65 Microbiome and Immunity P250–P260 p. 66 NK Cells & other Innate Immune Cells I P274–P288 p. 67 T Cells I P347–P394 p. 68 Transplantati on P425–P435 p. 72 Tumor Immunology & Immunotherapy I P436–P460 p. 73 Vaccinati on P477–P489 p. 75

15:30–17:00 Workshop • T Cell Development and Eﬀ ector Functi on Room Großer Saal Chairs Eva Tolosa (Hamburg/DE), Burkhardt Schraven (Magdeburg/DE)

15:30 NIK promotes the generati on of functi onal eﬀ ector T-cells O32 Sonja Lacher (Mainz/DE)

15:45 Glutathione primes T cell metabolism for inﬂ ammati on O33 Dirk Brenner (Esch-sur-Alzett e/LU; Odense/DK)

16:00 mTOR-dependent RNA biosynthesis in proliferati ng T cells O34 Stefanie Pennavaria (Planegg-Marti nsried/DE)

16:15 Senti nels of the oral epithelium: elucidati ng the development and O35 functi on of γδ T cells Anneke Wilharm (Hannover/DE)

16:30 A single microRNA controls MAIT cell development O36 Samantha Winter (Frankfurt/DE)

16:45 Dual role of IL-10 signaling for the control of CD4+ T cells O37 Tanja Bedke (Hamburg/DE)

29 S�� • W��, 13 S��

15:30–17:00 Workshop • Innate Immune Cells Room Kleiner Saal Chairs Alexander Steinle (Frankfurt/DE), Stefan Wirtz (Erlangen/DE)

15:30 Single-cell RNA-sequencing reveals novel potenti al regulators of innate O56 lymphoid cell functi on Antonia Wallrapp (Boston, MA/US)

15:45 ILC2 regulate adapti ve Th2 cell functi ons via PD-L1 checkpoint control O57 Christi an Schwartz (Dublin/IE)

16:00 Skin Langerhans cells sense the human pathogen Staphylococcus aureus O58 through the C-type lecti n receptor langerin (CD207) Nina van Sorge (Utrecht/NL)

16:15 Role of inﬂ ammati on-induced cytokines and CD4+ T cells in the functi on O59 of hepati c type 2 innate lymphoid cells Marek Schoedsack (Hamburg/DE)

16:30 Macrophage acti vati on and Entamoeba histolyti ca induced liver damage O60 are inﬂ uenced by sex and apolipoprotein A1 Jill Noll (Hamburg/DE)

16:45 Unique functi onal phenotype of iMATE-deﬁ ning monocytes and their O61 contributi on to local T cell proliferati on in the liver Kim Pawelka (Munich/DE)

15:30–17:00 Workshop • Microbiome and Immunity Room Konferenz 5 Chairs Mario Zaiss (Erlangen/DE), Oliver Pabst (Aachen/DE)

15:30 Intranasal applicati on of commensal bacteria restores murine microbiota O44 disturbed by anti bioti c treatment and mycobacterium tuberculosis i n f e c ti o n Matt hias Hauptmann (Borstel/DE)

15:45 Pseudomonas aeruginosa modulates the anti viral response of airway O45 epithelial cells Alexander Dalpke (Heidelberg/DE)

16:00 Kerati nocyte expression of JunB is a gatekeeper of immune-microbiota O46 crosstalk during systemic inﬂ ammati on Özge Uluçkan (Madrid/ES)

30 S�� • W��, 13 S��

16:15 Disti nct bacteria dictati ng mucosal TGF-beta and IgA inducti on O47 Hyun-Dong Chang (Berlin/DE)

16:30 Spontaneous gut commensal translocati on in systemic autoimmunity O48 that is preventable by vaccinati on Marti n Kriegel (New Haven, CT/US)

16:45 Salt-responsive gut commensal modulates TH17 axis and disease O49 Ralf Linker (Erlangen/DE), Dominik N. Müller (Berlin/DE)

15:30–17:00 Workshop • Chronic Inﬂ ammati on & Autoimmunity I Room Konferenz 3+4 Chairs Bimba Hoyer (Berlin/DE), Bernhard Manger (Erlangen/DE)

15:30 Pathogenic role of CD11b+ and Ly6C+ myeloid cells in chemically induced O38 mouse models of dermal ﬁ brosis Jessica Haub (Mainz/DE)

15:45 The role of IFNγ in the immune pathogenesis of primary sclerosing O39 cholangiti s Gevitha Ravichandran (Hamburg/DE)

16:00 Caloric restricti on inhibits pro-inﬂ ammatory monocyte egress from bone O40 marrow Stefan Jordan (New York, NY/US)

16:15 T-cell derived TNF inhibits IL-22 driven ti ssue repair during autoimmune O41 c o l i ti s Andrey Kruglov (Berlin/DE; Moscow/RU)

16:30 Is type I interferon-dependent systemic autoimmunity in absence of O42 Trex1 triggered by endogenous nucleic acids arising from retroelements or during DNA repair? Rayk Behrendt (Dresden/DE)

16:45 Biased T cell receptor (TCR) repertoire and changes in the course of O43 autoimmune disease aft er antenatal corti costeroid treatment (ACS) Anna Gieras (Hamburg/DE)

31 S�� • W��, 13 S��

15:30–17:00 Workshop • Vaccinati on Room Konferenz 1+2 Chairs Klaus Überla (Erlangen/DE), Damon Tumes (Adelaide/AU)

15:30 Anti gen targeti ng of Fc-receptors induces strong T cell responses in vivo O50 independent of ITAM signaling but dependent on dendriti c cell subset Christi an H. K. Lehmann (Erlangen/DE)

15:45 Decti n-1 positi ve dendriti c cells expand aft er infecti on with Leishmania O51 major parasites and represent promising targets for vaccine development Uwe Ritt er (Regensburg/DE)

16:00 A new RNA-based adjuvant enhances virus-speciﬁ c vaccine responses by O52 locally acti vati ng DC and inducing type I IFN responses TLR- and RLH-dependently Annett Ziegler (Hannover/DE)

16:15 Interleukin-23 promotes protecti ve multi functi onal CD4 memory T cell O53 responses aft er subunit Mycobacterium tuberculosis vaccinati on independently of interleukin-17A Kristi na Ritt er (Borstel/DE)

16:30 IL-1β as mucosal vaccine adjuvant: the speciﬁ c inducti on of O54 ti ssue-resident memory T cells leads to an enhanced protecti on against heterologous IAV Dennis Lapuente (Erlangen, Bochum/DE)

16:45 RNAi-mediated suppression of HBV restores HBV-speciﬁ c immunity and O55 enhances the eﬃ cacy of therapeuti c vaccinati on Anna Kosinska (Munich/DE)

17:00–17:30 Break

17:30–19:00 Plenary Session • B Cells (sponsored by TRR130) Room Großer Saal Chairs Hedda Wardemann (Heidelberg/DE), Falk Nimmerjahn (Erlangen/DE)

17:30 Autoanti bodies, mutati ons and excepti onal response to CTLA4-Ig therapy Christopher C. Goodnow (Sydney/AU) (Guest society ASI)

32 S�� • W��, 13 S��

18:00 B cell receptors, their Epstein-Barr viral mimics and lymphoproliferati ve disease Klaus Rajewsky (Berlin/DE)

18:30 A layer of splenic IgM „memory“ B cells is generated in the mouse from persistent mucosal immune responses Claude-Agnes Reynaud (Paris/FR) (Guest society SFI)

20:00–22:00 Young Immunologists Science-Dati ng Kitzmann BräuSchänke Südliche Stadtmauerstraße 25 | 91054 Erlangen within 5 min walking distance from venue parti cipati on at own expense

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08:30–10:30 Main Symposium • Post-transcripti onal and post-translati onal Control in the Immune System (sponsored by GRK1660) Room Großer Saal Chairs Susanne Heinzel (Parkville/AU), Ingo Schmitz (Braunschweig/DE)

08:30 Functi onal diversity of macrophage/monocyte subsets Shizuo Akira (Osaka/JP) (Guest society JSI)

09:00 Post-transcripti onal control of T cell diﬀ erenti ati on and Treg functi on Vigo Heissmeyer (Planegg-Marti nesried/DE)

09:30 Cholesterol regulates the acti vity of the TCR by an allosteric mechanism Wolfgang Schamel (Freiburg/DE)

10:00 Novel signalling pathways controlling T cell adhesion and migrati on Victor Tybulewicz (London/GB) (Guest society BSI)

08:30–10:30 Main Symposium • From Naive to Memory B Cells and Plasma Cells (sponsored by TRR130-IRTG) Room Kleiner Saal Chair Lars Nitschke (Erlangen/DE), Andreas Radbruch (Berlin/DE)

08:30 Biophysical compartmentalizati on of BCR signaling proteins promotes human anti body responses Jürgen Wienands (Götti ngen/DE)

09:00 Transcripti onal control of germinal centre development and plasma cell diﬀ erenti ati on Axel Kallies (Melbourne/AU) (Guest society ASI)

09:30 Dynamics of plasma cell niches Anja Hauser (Berlin/DE)

10:00 The multi functi onal and double-edged role of plasma cell derived IL-10 during inﬂ ammati on and infecti on Rudolf A. Manz (Lübeck/DE)

34 S�� • T��, 14 S��

08:30–10:30 Main Symposium • Detecti on of Damage and Danger Rooms Konferenz 5, video feed to Konferenz 1+2 Chairs Evelyn Ullrich (Frankfurt/DE), Carsten Watzl (Dortmund/DE)

08:30 MelLec: a new receptor for fungal infecti ons Gordon Brown (Aberdeen/GB) (Guest society BSI)

09:00 Detecti on of danger by acti vati ng NK cell receptors Adelheid Cerwenka (Heidelberg/DE)

09:30 Inﬂ ammasome signalling in the human system Veit Hornung (Munich/DE)

10:00 Sensing ti ssue damage through C-type lecti n receptors Sho Yamasaki (Fukuoka/JP) (Guest society JSI)

08:30–10:30 Main Symposium • Inﬂ ammatory Diseases (sponsored by IRTG-SFB1181) Room Konferenz 3+4 Chairs Gerd-Rüdiger Burmester (Berlin/DE), Reinhold Ernst Schmidt (Hannover/DE)

08:30 The role of ﬁ broblasts in the persistence of inﬂ ammati on Christopher Buckley (Edgbaston/GB) (Guest society BSI) 70. Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) e. V. 19.–21. Februar 2018 • Ruhr-Universität Bochum Tagungspräsidenten: Prof. Dr. med. Jan Buer Universitätsklinikum Essen Prof. Dr. med. Sören Gatermann Ruhr-Universität Bochum Prof. Dr. med. Frauke Mattner Kliniken der Stadt Köln gGmbH

Abstractdeadline: 31.10.2017 www.dghm-kongress.de l wikimedia org Branson l fotolia.com/Bill • 39012914 l reeel © 9919327 l Sebastian Kaulitzki 35 S�� • T��, 14 S��

09:00 Control of TH17 cells and associated cytokines in intesti nal inﬂ ammati on Samuel Huber (Hamburg/DE)

09:30 Targeti ng plasma cells as new treatment strategy in SLE and other anti body-mediated diseases Reinhard Edmund Voll (Freiburg/DE)

10:00 The role of Il-1 and IL-17 in autoimmunity Ari Waisman (Mainz/DE)

10:30–11:00 Industrial Exhibiti on and Coﬀ ee Break

11:00–12:30 Workshop • Infecti on II Room Großer Saal Chairs Anca Dorhoi (Greifswald/DE), Stella E. Autenrieth (Tübingen/DE)

11:00 Infecti on status vs. type I IFN producti on in plasmacytoid dendriti c cell in O70 MCMV infecti on Anja Schulze (Düsseldorf/DE)

11:15 Inﬂ uenza A virus infecti on during pregnancy: high progesterone levels O71 during pregnancy increase mortality in pregnant inﬂ uenza infected mice Alexandra Maximiliane Hierweger (Hamburg/DE)

11:30 Intravital lung imaging to study the interacti ons between immune cells O72 and Aspergillus fumigatus Sophie Henneberg (Essen/DE)

11:45 A unique interplay between PD-1+ leukocytes and human primary O73 myeloid cells during Leishmania infecti on Christodoulos Filippis (Langen/DE)

12:00 CYLD-deﬁ ciency protects from experimental cerebral malaria O74 Gopala Nishanth (Magdeburg/DE)

12:15 Wnt6-induced signaling drives formati on of triacylgylcerol-rich lipid O75 bodies and promotes survival of Mycobacterium tuberculosis in macrophages Julius Brandenburg (Borstel/DE)

36 S�� • T��, 14 S��

11:00–12:30 Workshop • Helper Cells and Treg Cells Room Kleiner Saal Chairs Christi na Zielinski (Munich/DE), Tobias Bopp (Mainz/DE)

11:00 Genome-wide comparison of human T helper cells and functi onal O88 characterizati on of newly identi ﬁ ed diﬀ erenti ally methylated regions Anna Ntalli, Stefan Floess (Braunschweig/DE)

11:15 Inducti on of regulatory T cells via T cell surface co-receptor CD43 O89 Madhura Modak (Vienna/AT)

11:30 Gut microbiota-derived metabolite butyrate induces expression of IFN-γ O90 and T-bet in T cells Alexander Visekruna (Marburg/DE)

11:45 Role of interferon regulatory factor 4 for memory T cell survival and O91 maintenance of their diﬀ erenti ati on state Aenne Harberts (Hamburg/DE)

12:00 The transcripti on factor NFATc3 promotes intesti nal inﬂ ammati on by O92 suppression of regulatory T cells Katharina Gerlach (Erlangen/DE)

12:15 Th1 transcripti on factor T-bet as a new target for Crohn’s disease therapy O93 Vanessa Popp (Erlangen/DE)

11:00–12:30 Workshop • Chronic Inﬂ ammati on & Autoimmunity II Room Konferenz 5 Chairs Alexander Steinkasserer (Erlangen/DE), Gerhild Wildner (Munich/DE)

11:00 Smoking is associated with low serum levels of soluble PD-L1 in O76 rheumatoid arthriti s Caroline Wasén (Gothenborg/SE)

11:15 Immunomodulatory functi on of the nuclear phosphor protein ANP32B in O77 mice Elisabeth Zinser (Erlangen/DE)

11:30 Novel anti -inﬂ ammatory properti es of the LIM-only protein Fhl2 O78 Viktor Wixler (Münster/DE)

11:45 Acti vati on of pyruvate kinase isoform M2 (PKM2) in myeloid cells O79 protects from Concanavalin A-mediated liver injury Jan Philipp Weltzsch, Andrea Kristi na Horst (Hamburg/DE) 37 S�� • T��, 14 S��

12:00 Interleukin 9 producing type 2 innate lymphoid cells are essenti al O80 mediators during resoluti on of inﬂ ammati on Andreas Ramming (Erlangen/DE)

12:15 CD101 inhibits chronic intesti nal inﬂ ammati on O81 Jochen Matt ner (Erlangen/DE)

11:00–12:30 Workshop • B Cells II Room Konferenz 3+4 Chairs Hermann Eibel (Freiburg/DE), Adriana Gruppi (Córdoba/AR)

11:00 Caveolin-1-dependent BCR nanoscale organizati on prevents B cell O82 malfuncti onand autoimmunity Susana Minguet (Freiburg/DE)

11:15 Molecular requirements of the B cell anti gen receptor for sensing O83 monovalent anti gens Jianying Yang (Freiburg/DE)

11:30 Insights into the functi on of IgD on human B cells from individuals with O84 heterozygous mutati ons in IGHD Henner Morbach (Würzburg/DE)

11:45 miR-148a controls plasma cell diﬀ erenti ati on and survival O85 Katharina Pracht (Erlangen/DE)

12:00 Salmonella remotely suppresses long-lasti ng humoral immunity O86 Koji Tokoyoda (Berlin/DE)

12:15 Regulati on of the IgE responses against helminths O87 Michaela Schmitt (Erlangen/DE)

38 S�� • T��, 14 S��

11:00–12:30 Workshop • Complement Room Konferenz 1+2 Chairs Jörg Köhl (Lübeck/DE), Peter F. Zipfel (Jena/DE)

11:00 Osteoblasts are target cells for complement component C5a in fracture O62 healing Anna Rapp (Ulm/DE)

11:11 The secreted S. aureus SplB disrupts host complement att ack by direct O63 cleavage and inacti vati on of complement proteins Prasad Dasari (Jena/DE)

11:22 Promoti ng adapti ve immunity: A new aspect to immune adherence? O64 Steven Broadley (Lübeck/DE)

11:32 Rati onally engineered proteins to potently regulate anti body-mediated O65 complement acti vati on Christoph Schmidt (Ulm/DE)

11:44 Monitoring C3aR expression using a ﬂ oxed tdTomato-C3aR reporter O66 knock-in mouse Yves Laumonnier (Lübeck/DE)

11:55 Candida albicans induces extracellular vesicles in human O67 monocytes/macrophages by exposure of b-glucan Luke Donald Halder (Jena/DE)

12:06 C5aR1 as a target to suppress the development and pathogenicity of O68 autoanti bodies in experimental epidermolysis bullosa acquisita Balint Kovacs (Lübeck/DE)

12:17 Free C3d enhances anti -tumor cellular immunity by blocking O69 tumor-induced immunossupression Marilia Cascalho (Ann Arbor, MI/US)

39 S�� • T��, 14 S��

12:30–13:30 Lunch Symposium* • 10x Genomics Room Großer Saal

Exploring immunology in high deﬁ niti on with the 10x chromium single cell genomics platf orms Brian Fritz (Basel/CH)

12:30–13:30 Lunch Symposium* • Agilent Technologies Sales & Service GmbH & Co. KG. Room Kleiner Saal

Opening up live-cell kineti c windows by applying metabolic readouts to fundamental immune processes of acti vati on, proliferati on and diﬀ erenti ati on David A. Ferrick (North Billerica, MA/US)

12:30–14:00 Lunch Symposium* • Acteria Alumni Lunch Session Chances and Challenges of a successful scienti ﬁ c Career Room Konferenz 3+4 Chairs Stefanie Eyerich (Berlin/DE), Dietmar Zehn (Munich/DE) Anne Hosmalin (Paris/FR)

Topics covered in round table discussion: • How to combine your scienti ﬁ c carrier with your private life • How and when to start as an independent investi gator • Topics YOU selected – see p. 21 how to submit a questi on

12:30–13:30 Industrial Exhibiti on and Lunch Break

*Lunch will be provided by sponsor. 40 S�� • T��, 14 S��

13:30–15:30 Poster Session II B Cells II P44–P66 p. 78 Chronic Inﬂ ammati on & Autoimmunity II P97–P118 p. 80 Complement P119–P132 p. 81 Dendriti c Cells P133–P157 p. 83 Infecti on II P207–P236 p. 85 NK Cells & other Innate Immune Cells II P289–P299 p. 87 Signaling and transcripti onal Regulati onin Immune Cells P321–P346 p. 88 Tumor Immunology & Immunotherapy II P461–P476 p. 90 Veterinary Immunology P490–P506 p. 92

14:00–15:00 1st Sekt & Selters Networking-Meeti ng Room Konferenz 5 Organizers Charlott e Esser (Düsseldorf/DE), Johannes vom Berg (Zurich/CH) DGfI Committ ee on Career Equality and Career Support patricipati on by pre-registrati on only (spaces are limited)

15:30–17:00 Workshop • Signaling and transcripti onal Regulati on in Immune Cells Room Großer Saal Chairs Ott mar Janßen (Kiel/DE), Marco Herold (Melbourne/AU)

15:30 A disti nct inhibitory functi on for miR-18a in Th17 cell diﬀ erenti ati on O100 Dirk Baumjohann (Planegg-Marti nsried/DE)

15:45 The serine/threonine phosphatase PP1α regulates nuclear import of O101 NF-kB via coﬁ lin dephosphorylati on in human T-cells Guido Wabnitz (Heidelberg/DE)

16:00 A complex of neuroplasti n and plasma membrane calcium ATPase O102 controls T cell acti vati on Mark Korthals (Magdeburg/DE)

16:15 Systems immunology approach reveals MEOX1 as a novel Treg-cell O103 speciﬁ c transcripti on factor Kevin Baßler (Bonn/DE)

16:30 TNFR2-acti vati on leads to TNF-induced TNFR1-mediated necroptosis in O104 murine macrophages Juliane Kums (Würzburg/DE)

16:45 Identi ﬁ ying novel regulators of the p53 induced tumour suppressor O105 network Marco Herold (Melbourne/AU)

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15:30–17:00 Workshop • NK Cells Room Kleiner Saal Chairs Dieter Kabelitz (Kiel/DE), Ulrike Schleicher (Erlangen/DE)

15:30 Evoluti on of HLA-C regulatory elements for NK-speciﬁ c expression: O106 implicati ons for NK self-educati on Stephen Anderson (Frederick, MD/US)

15:45 Chymase-producing cells of the innate immune system are required for O107 decidual vascular remodeling and fetal growth Nicole Meyer (Magdeburg/DE)

16:00 Pepti de-speciﬁ c recogniti on of human cytomegalovirus by adapti ve O108 natural killer cells Quirin Hammer (Berlin/DE)

16:15 Quanti tati ve analysis of NK cell reacti vity using latex beads O109 Carsten Watzl (Dortmund/DE)

16:30 Acti vated ti ssue-resident mesenchymal stromal cells regulate natural O110 killer cell immune and ti ssue regenerati ve functi on Alexander Maximilian Hackel (Essen/DE)

16:45 S100A4 – a novel key component of eﬀ ector immune cell synapses O111 Maxi Heyner (Braunschweig/DE)

15:30–17:00 Workshop • Tumor Evasion Room Konferenz 5 Chairs Hans-Georg Rammensee (Tübingen/DE), Thomas Gebhardt (Melbourne/AU)

15:30 Using in vivo photolabeling to uncover the fate of tumour-inﬁ ltrati ng O112 T cell migrati on in tumour immunity Tommaso Torcellan (Sydney/AU)

15:45 Inhibiti on of human T cells by the tumor metabolite MTA – mechanism of O113 acti on and MTAP-overexpression in T cells as putati ve strategy to improve a n ti t u m o r a c ti v i ty Carolin Strobl (Erlangen/DE)

16:00 ERAP1 overexpression in HPV-induced malignancies: a possible novel O114 immune evasion mechanism Angelika B. Riemer (Heidelberg/DE)

42 S�� • T��, 14 S��

16:15 The role of IL-33 on eﬀ ector regulator T cells in tumor immune evasion O115 Jonas Blume (Melbourne/AU)

16:30 High glycolyti c tumors evade immune destructi on by acidosis-dependent O116 inducti on of ICER in tumor-associated macrophages Toszka Bohn (Mainz/DE)

16:45 Helminth-induced intesti nal inﬂ ammati on facilitates tumor growth and O117 progression in coliti s-associated colon cancer Eva Pasti lle (Essen/DE)

15:30–17:00 Workshop • Dendriti c Cells Room Konferenz 3+4 Chairs Diana Dudziak (Erlangen/DE), Anne Dudeck (Magdeburg/DE)

15:30 Cellular reprogramming of human monocytes is regulated by O118 ti me-dependent IL4 signalling and NCOR2 Andreas Schlitzer (Bonn/DE)

15:45 Transcripti on factor Ikaros regulates the cDC2 lineage O119 Ben Roediger (Newtown/AU)

16:00 RelB-dependent CD117+ CD172a+ cDCs preferenti ally induce Th2 cell O120 responses Nico Andreas (Jena/DE)

16:15 Comparati ve analysis of human dendriti c cell subpopulati ons in steady O121 state and inﬂ ammati on Lukas Heger (Erlangen/DE)

16:30 Staphylococcus aureus PSM pepti des induce tolerogenic dendriti c cells O122 upon treatment with ligands of extracellular and intracellular TLRs Stella E. Autenrieth (Tübingen/DE)

16:45 Developmental heterogeneity of splenic dendriti c cells O123 Barbara Schraml (Planegg-Marti nsried/DE)

43 S�� • T��, 14 S��

15:30–17:00 Workshop • Veterinary Immunology Room Konferenz 1+2 Chairs Armin Saalmüller (Vienna/AT), Sonja Härtle (Munich/DE)

15:30 Detailed characterizati on of the chicken CCL16 orthologue O94 Sonja Härtle (Munich/DE)

15:45 CD28 expression and co-sti mulatory capacity in porcine T-cell subsets O95 Niklas Beyersdorf (Würzburg/DE)

16:00 Inﬂ uence of the mycotoxin deoxynivalenol (DON) on acti vati on and O96 cytokine producti on of porcine T cells in vitro Eleni Vatzia (Vienna/AT)

16:15 Host-speciﬁ c Mycoplasma mycoides induces interferon-related O97 response in embryonic bovine lung cells Jana Hänske (Insel Riems, Greifswald/DE)

16:30 Identi ﬁ cati on of porcine putati ve B-1 cells O98 Artur Summerﬁ eld (Mitt elhäusern/CH)

16:45 Inﬂ uence of the neonatal environment for the development of O99 respiratory immune cells Josephine Schlosser (Berlin/DE)

17:00–17:30 Break

17:30–19:00 Plenary Session • Infecti on (sponsered by MICE Erlangen) Room Großer Saal Chairs Christi an Bogdan (Erlangen/DE), Werner Solbach (Lübeck/DE)

17:30 Regulati on of inﬂ ammati on by MAMPs Gérard Eberl (Paris/FR) (Guest society SFI)

18:00 How to tackle the most successful pathogen on earth Stefan Kaufmann (Berlin/DE)

18:30 Mechanism of Potent mAb Treatment of Ebola Infecti on Nancy Sullivan (Bethesda, MD/US)

19:00–20:45 General Assembly of the DGfI Room Kleiner Saal (see p. 7)

44 S�� • T��, 14 S��www.conventus.de

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08:30–10:30 Main Symposium • Immune Tolerance (sponsored by GRK1660) Room Großer Saal Chairs Christi ne Falk (Hannover/DE) Hans-Reimer Rodewald (Heidelberg/DE)

08:30 Regulatory T cells in ti ssues Markus Feuerer (Heidelberg/DE)

09:00 TCR signaling, Treg, and autoimmunity Shimon Sakaguchi (Kyoto/JP) (Guest society JSI)

09:30 Learning the rules of programmed cell death to develop novel cancer therapeuti cs Andreas Strasser (Bundoora/AU) (Guest society ASI)

10:00 Natural Killer cell tolerance for self Wayne M. Yokoyama (St. Louis, MO/US) (Guest society AAI)

08:30–10:30 Main Symposium • Anti microbial Eﬀ ector Functi ons Room Kleiner Saal Chairs Virginia Elena Rivero (Córdoba/AR), Roland Lang (Erlangen/DE)

08:30 Skin infecti ons are eliminated by cooperati on of the ﬁ brinolyti c and innate immune systems Francesca Granucci (Milan/IT) (Guest society SIICA)

09:00 Interferon-dependent anti bacterial defense in lung infecti ons Basti an Opitz (Berlin/DE)

09:30 Interferon induced guanylate binding proteins as eﬀ ector molecules of immunity Klaus Dieter Pfeﬀ er (Düsseldorf/DE)

10:00 How cell-autonomous immunity defends the cytosol against bacteria Felix Randow (Cambridge/GB) (Guest society BSI)

46 S�� • F��, 15 S��

08:30–10:30 Main Symposium • Allergy: Mechanisms and Diagnosti cs Joint Symposium DGfI/DGAKI Rooms Konferenz 5, video feed to Konferenz 1+2 Chairs Stefan Marti n (Freiburg/DE), Winfried F. Pickl (Vienna/AT)

08:30 The concept of AllergoOncology Erika Jensen-Jarolim (Vienna/AT) (Guest society ÖGAI)

09:00 DC-epithelial interacti ons at the incepti on of asthma Bart Lambrecht (Gent/BE)

09:30 Environmental microbes, hygiene hypothesis, and asthma preventi on: molecular mechanisms Harald Renz (Marburg/DE)

10:00 Airborne allergens: the “ti p of the iceberg” escaping Treg mediated tolerance Alexander Scheﬀ old (Berlin/DE)

08:30–10:30 Main Symposium • Metabolic Control of Immune Responses (supported by GK1660) Room Konferenz 3+4 Chair Yvonne Samstag (Heidelberg/DE) Tim Sparwasser (Hannover/DE)

08:30 Manipulati ng the respiratory chain to acti vate immune responses and target cancer metabolism Olaf Groß (Munich/DE)

09:00 Elementary control of innate immunity by Na+ Jonathan Jantsch (Regensburg/DE)

09:30 The role of the GSK3/beta-Catenin signaling pathway in metabolic homeostasis of B cells Julia Jellusova (Freiburg/DE)

10:00 Warburg meets Immunology: lacti c acid blunts immune cell functi on Marina Kreutz (Regensburg/DE)

10:30–11:00 Industrial Exhibiti on and Coﬀ ee Break

47 S�� • F��, 15 S��

11:00–12:30 Workshop • Cytotoxic T Cells Room Großer Saal Chairs Magdalena Huber (Marburg/DE), Percy A. Knolle (Munich/DE)

11:00 Exhausti on of virus-speciﬁ c CXCR6+ liver-resident memory CD8 T cells O148 during persistent liver infecti on Nina Kallin (Munich/DE)

11:15 Eﬀ ector memory CD8+ T cells speciﬁ c for a single low-avidity epitope O149 confer immune protecti on in a cytomegalovirus-based vaccinati on model Katarzyna Sitnik (Braunschweig/DE)

11:30 Microbiota regulate the metabolic adaptati ons required for the transiti on O150 of eﬀ ector cells into circulati ng, but not ti ssue resident CD8+ T cell memory Sammy Bedoui (Parkville/AU)

11:45 Dimethyl fumarate limits Tc17 diﬀ erenti ati on via increased ROS levels and O151 metabolic reprogramming Christi na Lueckel (Marburg/DE)

12:00 Long-term anti gen-driven proliferati on of eﬀ ector T cells maintains O152 CD8 T cell memory in MCMV infecti on Luka Cicin-Sain (Braunschweig/DE)

12:15 Opti mal expansion of CD8+ memory precursors is dependent on O153 sustained anti gen presence Veit R. Buchholz (Munich/DE)

11:00–12:30 Workshop • Innate Receptors & Sensors Room Kleiner Saal Chairs Gunther Hartmann (Bonn/DE), Cecile King (Darlinghurst/AU)

11:00 C-reacti ve protein inhibits ATP-mediated maturati on and secreti on of O142 interleukin-1β in human monocytes Katrin Richter (Giessen/DE)

11:15 RIG I senses ribosomal RNA derived degradati on products O143 Stephanie Jung (Munich, Marburg/DE)

11:30 The nucleoprotein high-mobility group box 1 criti cally regulates the O144 immune response to bacterial infecti on Annika Volmari (Hamburg/DE)

48 S�� • F��, 15 S��

11:45 The pathogen speciﬁ c nucleoside 5”-methylthioinosine is a new TLR8 O145 ligand Gabi Köllisch (Marburg/DE)

12:00 Crystal-induced NLRP3-dependent inﬂ ammasome induces ILC3 O146 acti vati on and promotes local inﬂ ammati on Teresa Frasconi (Bonn/DE)

12:15 Bacterial signal pepti des detecti on by formyl pepti de receptors provides a O147 new mechanism for sensing pathogens Bernd Bufe (Zweibrücken, Homburg/DE)

11:00–12:30 Workshop • Allergy & Immunodeﬁ ciencies Room Konferenz 5 Chairs Stefanie Eyerich (Munich/DE), Bodo Grimbacher (Freiburg/DE)

11:00 Modulati on of the immune reponse to subcutaneous grass pollen-speciﬁ c O136 immunotherapy by vitamin D – data from a controlled clinical pilot trial Guido Heine (Berlin/DE)

11:15 Unexpected mechanism of glucocorti coid therapy in a mouse model of O137 allergic asthma Holger Reichardt (Götti ngen/DE)

11:30 Neutrophil extracellular traps may play a role in alum-adjuvanted O138 allergen-speciﬁ c immunotherapy Manuel Reithofer (Vienna/AT)

11:45 Single center experience in targeted NGS for geneti c diagnosis of primary O139 immunodeﬁ ciency Yu Xia (Shenzhen/CN; Stockholm/SE)

12:00 Hyper IgE syndrome-like phenotype in a pati ent with ARPC1B deﬁ ciency O140 Alexander Blank (Ulm/DE)

12:15 The impact of the absence of LRBA on immune regulatory mechanisms O141 Felicitas Felber (Freiburg/DE)

49 S�� • F��, 15 S��

11:00–12:30 Workshop • Regulatory Immune Cells Room Konferenz 3+4 Chairs Petra Hoﬀ mann (Regensburg/DE), Jürgen Ruland (Munich/DE)

11:00 Regulati on and functi on of Blimp1 in Foxp3+ regulatory T cells during O130 autoimmune CNS inﬂ ammati on Garima Garg (Munich/DE)

11:15 Deciphering vital functi ons of c-FLIP for regulatory T cells O131 Carlos Plaza Sirvent (Magdeburg, Braunschweig/DE)

11:30 Stromal cells of gut-draining lymph nodes stably att ain tolerogenic O132 properti es and modulate functi onal properti es of dendriti c cells Joern Pezoldt (Braunschweig/DE)

11:45 RORgt can be expressed on both thymus-derived and O133 peripherally-induced Foxp3+ regulatory T cells Juhao Yang (Braunschweig/DE; Beijing/CN)

12:00 Inﬂ uence of inﬂ uenza A virus infecti on on thymic development and O134 peripheral homeostasis of Foxp3+ tegulatory T cells Yassin Elfaki (Braunschweig/DE)

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12:15 Blockade of CTLA-4 impairs anti bacterial immunity by reducing CD8+ O135 T cell acti vati on and increasing IL-10 producti on by T cells in murine infecti on with Orienti a tsutsugamushi Christi an Keller (Marburg/DE)

11:00–12:30 Workshop • Neuroimmunology Room Konferenz 1+2 Chairs Ulrike Gimsa (Dummerstorf/DE), Anne Brüstle (Canberra/AU)

11:00 Multi plexed mass cytometry proﬁ ling of human post-mortem brain O124 microglia Choti ma Bött cher (Berlin/DE)

11:15 Role of novel immune checkpoint molecules in multi ple sclerosis O125 Ayse Nur Menevse (Regensburg/DE)

11:30 Inﬂ ammati on dependent upregulati on of CCL17 in hippocampal neurons O126 and its inﬂ uence on neuro-immune interacti ons Lorenz Fülle (Bonn/DE)

11:45 A spectrum of neural autoanti gens, newly identi ﬁ ed by O127 histo-immunoprecipitati on, mass spectrometry and recombinant cell-based indirect immunoﬂ uorescence Lars Komorowski (Lübeck/DE)

Flow Cytometry for bio medical research 12:00 OTUB1 ameliorates experimental autoimmune encephalomyeliti s by CyFlow® – new software and O128 inhibiti ng IFN-γ-dependent astrocyte acti vati on hardware solutions Xu Wang (Magdeburg/DE)

12:15 Age-dependent eff ects of dopamine on fi broblast aggressive phenotype Check out our new antibody webshop: O129 in arthriti s pati ents www.sysmex-fl owcytometry.com Silvia Capellino (Dortmund/DE)

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12:30–13:30 Lunch Symposium* • AYOXXA Biosystems GmbH More from less – multi plex Protein Detecti on in Inﬂ ammati on Room Kleiner Saal

Welcome

AYOXXA’s LUNARISTM protein multi plexing platf orm: an introducti on Oliver Gresch (AYOXXA Biosystems)

AYOXXA’s LUNARISTM protein multi plexing platf orm: analyzing diﬀ erent matrices Isabelle Koxholt (AYOXXA Biosystems)

Murine sepsis model: cytokines and their role for a poor outcome Marika Enders (Bonn/DE)

12:30–13:30 Lunch Symposium* • NanoString Technologies Germany GmbH Room Konferenz 3+4

NanoString Technology: empowering IO research with the new PanCancer IO 360 gene expression panel Sarah Warren (Seatt le, WA/US) First come, first serve Get your personal goody bag! 12:30–13:30 Industrial Exhibiti on and Lunch Break Meet us at booth No. 58 13:30–16:00 Poster Session III Allergy P1–P9 p. 94 Neuroimmunology P261–P273 p. 94 Regulatory Immune Cells P300–P320 p. 96 T Cells II P395–P424 p. 97

16:00–17:00 Award of Poster Prizes Room Großer Saal

Awarded by Hans-Marti n Jäck, Joachim Kalden Marti n Röllinghoﬀ & Michael Lohoﬀ

Krebskoffer

*Lunch will be provided by sponsor. 52 S�� • F��, 15 S��

17:00–18:30 Plenary Session • Clinical Immunology (sponsored by SFB1181) Room Großer Saal Chairs Joachim Kalden (Erlangen/DE), Thomas Kamradt (Jena/DE)

17:00 Targeti ng the mutanome for individualized cancer immunotherapy Ugur Sahin (Mainz/DE)

17:30 Microbiome at the edge of inﬂ ammati on and tumorigenesis Dirk Haller (Freising/DE)

18:00 Inducti on and resoluti on of inﬂ ammati on in the joints Georg Schett (Erlangen/DE)

18:30–19:00 Closing Remarks Room Großer Saal

19:15–04:00 Scienti ﬁ c Plenary Debate followed by Social Evening E-Werk Erlangen (see p. 112)

First come, first serve Get your personal goody bag! Meet us at booth No. 58

Krebskoffer

53 P��

Poster Session I • Wednesday, 13 September • 13:30–15:30 Anti gen Presentati on P10–P20 p. 56 B Cells I P22–P43 p. 57 Chronic Inﬂ ammati on & Autoimmunity I P67–P96 p. 58 Immune Diagnosti cs and Monitoring P159–P164 p. 61 Immunodeﬁ ciency P165–P172 p. 61 Infecti on I P173–P206 p. 63 Innate Receptors and Sensors P237–P249 p. 65 Microbiome and Immunity P250–P260 p. 66 NK Cells & other Innate Immune Cells I P274–P288 p. 67 T Cells I P347–P394 p. 68 Transplantati on P425–P435 p. 72 Tumor Immunology & Immunotherapy I P436–P460 p. 73 Vaccinati on P477–P489 p. 75

Poster Session II • Thursday, 14 September • 13:30–15:30 B Cells II P44–P66 p. 78 Chronic Inﬂ ammati on & Autoimmunity II P97–P118 p. 80 Complement P119–P132 p. 81 Dendriti c Cells P133–P157 p. 83 Infecti on II P207–P236 p. 85 NK Cells & other Innate Immune Cells II P289–P299 p. 87 Signaling and transcripti onal Regulati onin Immune Cells P321–P346 p. 88 Tumor Immunology & Immunotherapy II P461–P476 p. 90 Veterinary Immunology P490–P506 p. 92

Poster Session III • Friday, 15 September • 13:30–16:00 Allergy P1–P9 p. 94 Neuroimmunology P261–P273 p. 94 Regulatory Immune Cells P300–P320 p. 96 T Cells II P395–P424 p. 97

All presenti ng poster authors are kindly asked to be present during the assigned poster session. Thank you!

54 S�� • F��, 15 S�� SAVE THE DATE 2017 DZIF ACADEMY 5th TRANSLATIONAL DZIF-SCHOOL 22–24 November LÜBECK ATLANTIC HOTEL Key Topics • Emerging Infections • Tuberculosis • HIV • Healthcare-associated and Antibiotic-resistant bacterial Infections • Novel Antibiotics

www.dzif-autumn-school.de © 67795350 l Andreas Edelmann / 72696972 l Artalis-Kartographie / 69654140 l Michael l Fotolia.com

55 P�� I • W��, 13 S�� • 13:30–15:30

Anti gen Presentati on P10–P20 p. 56 B Cells I P22–P43 p. 57 Chronic Inﬂ ammati on & Autoimmunity I P67–P96 p. 58 Immune Diagnosti cs and Monitoring P159–P164 p. 61 Immunodeﬁ ciency P165–P172 p. 61 Infecti on I P173–P206 p. 63 Innate Receptors and Sensors P237–P249 p. 65 Microbiome and Immunity P250–P260 p. 66 NK Cells & other Innate Immune Cells I P274–P288 p. 67 T Cells I P347–P394 p. 68 Transplantati on P425–P435 p. 72 Tumor Immunology & Immunotherapy I P436–P460 p. 73 Vaccinati on P477–P489 p. 75

Anti gen Presentati on P10 Negati ve impact of homozygosity in HLA-DQB1 locus on HIV-associated tuberculosis Oksana Kolesova, Jelena Eglite, Inga Azina, Baiba Rozentale (Riga/LV) P11 Major role of the AAA-ATPas p97 (VCP) in direct anti gen processing and presentati on on MHC class I Annegret Bitzer (Konstanz/DE), Michael Basler Marcus Groett rup (Konstanz/DE; Kreuzlingen/CH) P12 Defi ning the interplay of phagocytes with L. major proliferati on using a new reporter system in vivo Sandrina Heyde, Pauline Formaglio (Magdeburg/DE) Andreas J. Müller (Magdeburg, Braunschweig/DE) P13 Systems biology of MHC class I anti gen presentati on studied in human cancer cell lines Jennifer Hahlbrock, Pedro Navarro, Meike Wagner, Sebasti an Boegel, Hansjörg Schild Ugur Sahin, Stefan Tenzer (Mainz/DE) P14 Generati on of stringent HLA class I-pepti de moti fs using primary ti ssue enabling identi fi cati on of allotypic pepti des for HLA class I typing Michael Ghosh, Moreno Di Marco, Heiko Schuster, Hans-Georg Rammensee Stefan Stevanović (Tübingen/DE) P15 Renal proximal tubular epithelial cells functi on as non-professional APCs and induce pro-infl ammatory CD4+ T-cell acti vati on Philippe Christophe Breda, Catherine Meyer-Schwesinger, Ulf Panzer, Gisa Tiegs Katrin Neumann (Hamburg/DE) P16 Characterizing the immunogenicity of DM-sensiti ve and DM-resistant anti gens and their role in anti tumor immunity Anna Luise Bernhardt, Sascha Kretschmann, Judith Bausenwein, Hannah Kranich Tabea Haug, Andreas Mackensen, Anita N. Kremer (Erlangen/DE) P17 Complete human leukocyte anti gen gene sequence determinati on by combining long range polymerase chain reacti on and next generati on sequencing Thomas M.C. Binder (Hamburg/DE), Reinhard Kelsch (Münster/DE) Sikder N. I. Rabbi (Dhaka/BD), Erwin Strasser (Erlangen/DE), Lena Krammes Tobias Roth (Birkenfeld/DE), Thomas H. Eiermann (Hamburg/DE), Marco Schäfer Wolfgang Peter (Birkenfeld/DE)

56 P�� I • W��, 13 S�� • 13:30–15:30

P18 Eﬀ ects of cigarett e smoke on proteasome-dependent MHC I anti gen presentati on Ilona Kammerl, Angela Dann, Christi na Lukas, Oliver Vosyka (Munich/DE), Judith Brands Marta Bueno Fernandez (Pitt sburgh, PA/US), Dorothee Brech, Elfriede Nössner Oliver Eickelberg (Munich/DE), Ana Mora (Pitt sburgh, PA/US), Silke Meiners (Munich/DE) P19 The role of ISG15 in proteasomal degradati on and MHC class I anti gen presentati on Tobias Held, Marcus Groett rup (Konstanz/DE) P20 Non-canonical ubiquiti nati on drives MHC class I processing and presentati on of the NY-ESO-1 cancer-testi s anti gen Richard Golnik, Andrea Lehmann, Peter-Michael Kloetzel, Frédéric Ebstein (Berlin/DE)

B Cells I P22 Identi fi cati on of novel STAT6-regulated proteins in mouse B cells by comparati ve transcriptome and proteome analysis Lavanya Mokada Gopal (Erlangen/DE), Alexander Boeser (Freiburg/DE) Christi an H. K. Lehmann, Diana Dudziak (Erlangen/DE), Betti na Warscheid (Freiburg/DE) David Vöhringer (Erlangen/DE) P23 TRK-fused gene (TFG) prevents ER stress, apoptosis and autophagy in CH12.LX mature B lymphoma cells Tobit Steinmetz, Dirk Mielenz (Erlangen/DE) P24 Infl uence of Swiprosin2/EFhd1 on the metabolic control of B cell diff erenti ati on and humoral immunity Sophia Urbanczyk, Merle Stein, Sebasti an Dütti ng, Dimitrios Mougiakakos, Michael Bösl Dorothea Reimer, Tobit Steinmetz, Wolfgang Schuh, Aline Bozec, Thomas Winkler Hans-Marti n Jäck, Dirk Mielenz (Erlangen/DE) P25 The role of Siglec proteins in autoimmunity and leukemia Hannah Seifried, Lars Nitschke (Erlangen/DE) P26 The infl uence of Sialic acids on the development and functi on of B and T cells: characterizati on of CMAS knockout mice Alexandra Weise (Erlangen/DE), Birgit Weinhold, Rita Gerardy-Schahn (Hannover/DE) Lars Nitschke (Erlangen/DE) P27 The importance of the NFAT5/TonEBP-mediated osmoti c stress response in B cells Ljiljana Rokvic (Erlangen/DE), Patrick Neubert, Jens Titze (Erlangen/DE; Nashville, TN/US) Hans-Marti n Jäck, Wolfgang Schuh (Erlangen/DE) P28 Identi fi cati on of DGCR8-dependent regulators of pro-B cell development and survival Sebasti an Schulz, Andreas Brandl, Patrick Daum, Sven Brenner (Erlangen/DE) Michael Bösl (Würzburg/DE), Jürgen Witt mann, Wolfgang Schuh Hans-Marti n Jäck (Erlangen/DE) P29 Characterizati on of the Cd22 and Siglec-G Interactome Sarah Mrotzek (Erlangen/DE), Alexander Böser, Lena Reimann Betti na Warscheid (Freiburg/DE), Lars Nitschke (Erlangen/DE) P30 CTLA4-Ig treatment induces modulati on on B cells functi on and diff erenti ati on Raquel Lorenzetti , Nadine Henneberger, Iga Janowska, Nils Venhoff , Jens Thiel Marta Rizzi (Freiburg/DE) P31 Study of the modulatory role of Fas in B cell acti vati on Julian Staniek, Jan Raabe, Iga Janowska, Raquel Lorenzetti , Cristi an Smulski (Freiburg/DE) Pascal Schneider (Lausanne/CH), Bénédicte Neven (Paris/FR), Luis M. Allende (Madrid/ES) Albert Català-Temprano (Barcelona/ES), Olaf Neth, Peter Olbrich (Sevilla/ES) Tomas Kalina (Prague/CZ), Anne Rensing-Ehl, Marta Rizzi (Freiburg/DE) 57 P�� I • W��, 13 S�� • 13:30–15:30

P32 miR-148a – Necessary for the generati on and maintenance of long-lived plasma cells? Julia Meinzinger, Katharina Pracht, Patrick Daum, Joana Côrte-Real, Manuela Hauke Sebasti an Schulz, Edith Roth, Jürgen Witt mann, Hans-Marti n Jäck (Erlangen/DE) P33 EFhd2 regulates the cytoskeleton of B lymphocytes and impact the germinal center reacti on Dorothea Reimer (Erlangen/DE), Raluca Niesner (Berlin/DE), Tobit Steinmetz Sebasti an Brachs, David Vöhringer, Dirk Mielenz (Erlangen/DE) P34 The microRNA processing subunit DGCR8 is required for immune response and germinal center formati on Patrick Daum, Julia Meinzinger, Katharina Pracht, Joana Cortê-Real, Manuela Hauke Jürgen Witt mann, Hans-Marti n Jäck (Erlangen/DE) P35 In vitro modeling of defects in early B cell development in primary anti body defi ciencies Arianna Troilo, Claudia Wehr, Iga Janowska, Klaus Warnatz, Justi na Rawluk, Ulrich Salzer Marta Rizzi (Freiburg/DE) P36 A new mechanism of anti body diversifi cati on Kathrin Pieper, Joshua Tan, Luca Piccoli, Mathilde Perez, Chiara Silacci Sonia Barbieri (Bellinzona/CH), Peter Crompton (Rockville, MD/US) Claudia Daudenberger (Basel/CH), Peter Bull (Cambridge/GB), Federica Sallusto Antonio Lanzavecchia (Bellinzona/CH) P37 Impact of nuclear hormone receptor acti vati on on human B cell diff erenti ati on Sandra Treptow, Joachim Grün, Andreas Radbruch, Guido Heine Margitt a Worm (Berlin/DE) P38 Cooperati on of Jak/STAT and NF-kB pathway acti vity regulates GOT2 expression and glutaminolysis in proliferati ng B cells Maren Feist (Götti ngen/DE), Philipp Schwarzfi scher, Paul Heinrich (Regensburg/DE) Judith Kemper (Götti ngen/DE), Paula Perez-Rubio, Katja Dett mer, Wolfram Gronwald Julia Engelmann, Rainer Spang, Peter Oefner (Regensburg/DE) Dieter Kube (Götti ngen/DE) P39 Leishmania infantum induces B cell IL-10 producti on which causes disease aggravati on in experimental visceral leishmaniasis Jennifer Heinemann, Heidi Sebald, Christi an Bogdan, Ulrike Schleicher (Erlangen/DE) P40 Nanoscale Organizati on of the BCR and inside-out signaling by Syk Kathrin Kläsener, Marco Cavallari, Jianying Yang, Michael Reth (Freiburg/DE) P41 Engineering cell functi ons with intracellular anti bodies Andrea L. J. Marschall, Natalie Lange, Rina M. Ötjengerdes, Stefan Dübel Michael Meyer-Hermann (Braunschweig/DE) P42 Taci polymorphisms associated with de novo alloanti bodies in humans and allograft rejecti on in mice Marilia Cascalho, Jeff rey Platt , Evan Farkash (Ann Arbor, MI/US) P43 The role of B cells for IgG sialylati on Anja Schaff ert, Falk Nimmerjahn (Erlangen/DE)

Chronic Inﬂ ammati on & Autoimmunity I P67 N-(2-hydroxyphenyl)-Acetamide improves adjuvant-induced arthriti s by suppressing exaggerated levels of proinﬂ ammatory cytokines and toll-like receptors (TLR-2 AND TLR-4) Shabana Simjee, Kahkashan Perveen, Huma Jawed (Karachi/PK)

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P69 The synthesis and characterisati on of helminth bioacti ve pepti des as potenti al therapeuti c treatments for autoimmune diseases Taylor Smallwood, Richard Clark, Jason Mulvenna, Johan Rosengren (Brisbane/AU) John Miles (Cairns/AU) P70 Low dose radiati on alters the infl ammatory phenotype of fi broblast-like synoviocytes and impacts on bone metabolism Lisa Deloch, Benjamin Frey, Jana Liberg, Anja Derer, Rainer Fietkau Udo S. Gaipl (Erlangen/DE) P71 Postt ranslati onal modifi cati ons of IgG auto-anti bodies Jasmin Knopf, Mona Biermann, Luis Munoz, Marti n Herrmann (Erlangen/DE) P72 Transcriptomic and proteomic profi ling of iris from pati ents with juvenile idiopathic arthriti s-associated uveiti s Lena Wildschütz, Doreen Ackermann, Anika Witt en, Maren Kasper, Marti n Busch Shirin Glander, Harut Melkonyan, Karoline Walscheid (Münster/DE) Christoph Tappeiner (Bern/CH), Solon Thanos (Münster/DE) Björn Laff er (Münster, Essen/DE), Dirk Bauer, Monika Stoll, Simone König (Münster/DE) Arnd Heiligenhaus (Münster, Essen/DE) P73 Disti nct microbial communiti es trigger coliti s development aft er damage to the intesti nal barrier via innate or adapti ve immune cells Till Strowig (Braunschweig/DE) P74 The role of B- and T-cells in a model of atopic dermati ti s Joerg U. Eberle, David Vöhringer (Erlangen/DE) P76 Varicella-Zoster-Virus (VZV)-specifi c cellular immune response in lymphocytes in vitro treated with Tofaciti nib Giovanni Almanzar, Felix Kienle, Frank Deininger, Marti na Prelog (Würzburg/DE) P77 Paracetamol and pregnancy – immunological consequences for mother and child Lars Bremer, Felix Stahl, Petra Arck, Gisa Tiegs (Hamburg/DE) P78 Siglec-H protects from virus-triggered severe systemic autoimmunity Heike Schmitt , Nadine Szumilas (Erlangen/DE), Odilia Corneth Rudi Hendriks (Rott erdam/NL), Thomas Winkler, Lars Nitschke (Erlangen/DE) P79 A novel murine model system trisomic for Hsa21 orthologous genes shows an immune phenotype partly similar to human Trisomy 21 pati ents Katharina Charlott e Reimer, Christi an Herbert, Kurt Lehmann (Erlangen/DE) Anna Baranska (Erlangen/DE; Marseille/FR), Gordon Frederik Heidkamp, Lukas Heger Jennifer Johanna Lühr, Inessa Schwab, Ariawan Purbojo, Robert Cesnjevar Falk Nimmerjahn, Diana Dudziak (Erlangen/DE) P80 The role of Siglec-E/9 in osteoclastogenesis and arthriti s Fabian Andes, Ulrike Harre, Lars Nitschke, Georg Schett (Erlangen/DE) P81 Characterizati on of the role of membrane expressed and soluble CD83 molecules in Foxp3+ regulatory T cell (Tregs) functi on in the context of infl ammatory bowel disease Christi na König, Marina Döbbeler, Matt hias Lechmann Alexander Steinkasserer (Erlangen/DE) P83 Elucidati on of the functi onal role of IDO in sCD83-mediated immune-modulati on in arthriti s Dmytro Royzman, Lena Sandrock (Erlangen/DE), Cecilia Engdahl (Gothenburg/SE) Alexander Steinkasserer, Elisabeth Zinser (Erlangen/DE) P84 Elucidati on of interacti on partners and biological functi on of CD83 Andreas Wild, Lena Krzyzak, Alexander Steinkasserer (Erlangen/DE) 59 P�� I • W��, 13 S�� • 13:30–15:30

P85 The role of Siglec-15 in inducti on and resoluti on of infl ammati on Marina Korn, Heike Schmitt , Michaela Seeling, Falk Nimmerjahn,Lars Nitschke (Erlangen/DE) P86 Low-level expression of IL-17A links psoriati c skin lesion development to cardiovascular disease Anna Brand, Rebecca Schüler (Mainz/DE), Christi an Wohn (Rott erdam/NL) Nathalie Diener, Ronald Backer, Susanne Karbach, Philip Wenzel, Ari Waisman Björn E. Clausen (Mainz/DE) P87 Autoreacti ve T cells induce autoanti bodies against known skin autoanti gens aft er transfer into nu/nu mice Stefanie Haeberle, Britt a Heckmann, Stefanie Marti nache, Alexander Enk Eva Hadaschik (Heidelberg/DE) P88 Semi-automated screening of organoid cultures to test eff ects of potenti al therapeuti cs on anti microbial functi ons and ti ssue regenerati on in the intesti ne Jenny Ostrop, Rosalie Zwiggelaar, Mara Marti n Alonso, Roos Spanjers (Trondheim/NO) Cheryl Arrowsmith (Toronto/CA), Menno Oudhoff (Trondheim/NO) P89 Ex-vivo evaluati on of the eff ect of high-density lipoprotein on the functi onal acti viti es of macrophage in human early type 1 diabetes Ibti ssem Benghalem, Warda Meziane, Zeyneb Hadjidj, Ahmed Belamri, Kheira Mouhadjer Mourad Aribi (Tlemcen/DZ) P90 Autoreacti ve T cell responses in membranous nephropathy Daniel Reimers, Rolf A. K. Stahl, Ulf Panzer, Elion Hoxha Hans-Willi Mitt rücker (Hamburg/DE) P91 Altered circulati ng and local expression of interleukin-21 and IL-21 receptor in granulomatosis with polyangiiti s Gesche Weppner, Konstanze Holl-Ulrich, Katrin Hasselbacher, Gabriela Riemekasten Peter Lamprecht, Antje Müller (Lübeck/DE) P92 CEACAM1 controls immune-mediated liver injury by promoti ng IL-2-dependent Treg inducti on Andrea Kristi na Horst, Claudia Wegscheid, Christoph Schaefers Birgit Schiller (Hamburg/DE), Karl Sebasti an Lang, Bernhard B. Singer (Essen/DE) Linda Diehl, Gisa Tiegs (Hamburg/DE) P93 The nuclear receptor Nr4a1 acts as microglia rheostat and serves as therapeuti c target in autoimmune-driven CNS infl ammati on Maria Faas (Erlangen/DE) P94 Eff ect of oxidati ve stress and pro-infl ammatory cytokines in the pathogenesis of type 2 diabetes Naureen Fati ma, Shaguft a Moin (Aligarh/IN) P95 T helper cells with specifi city for an anti gen in cardiomyocytes promote progression rom hypertrophy to heart failure aft er transverse aorti c constricti on independently of autoanti bodies Carina Gröschel, Charlott e Röhrborn, André Sasse, Sebasti an Monecke, Leslie Elsner Michael Didié, Karl Toischer, Wolfram-Hubertus Zimmermann, Gerd Hasenfuß Ralf Dressel (Götti ngen/DE) P96 GPR15 expression on T cells – impact on the pathogenesis of ulcerati ve coliti s Alexandra Adamczyk, Daniel Gageik, Annika Frede, Eva Pasti lle Wiebke Hansen (Essen/DE), Andreas Rüff er (Bad Bocklet-Großenbrach/DE) Jan Buer (Essen/DE), Jürgen Büning (Lübeck/DE), Jost Langhorst Astrid M. Westendorf (Essen/DE) 60 P�� I • W��, 13 S�� • 13:30–15:30

Immune Diagnosti cs and Monitoring P159 IFN- γ and IL-12 are decrease in relapsing pati ents with Hydati dosis – new approach diagnosti c and immunosurveillance Dalila Mezioug, Chafi a Touil (Algiers/DZ) P160 Development and characterizati on of Gaussia princeps luciferase (GpL) anti body fusion proteins specifi c for receptors of the TNF receptor superfamily Johannes Nelke, Juliane Kums, Benedikt Rüth, Viktoria Schäfer, Daniela Siegmund Harald Wajant (Würzburg/DE) P161 Diagnosti c value of seric purine catabolism by adenosine deaminase and xanthine oxidase acti viti es screening in Algerian cervical cancer pati ents Nabila Tounsi, Assia Benyelles-Boufennara, Bahia Djerdjouri (Algiers/DZ) P162 Altered B cell homeostasis in pati ents with major depressive disorder and normalizati on of regulatory B cell frequencies in treatment responders Diana Ahmetspahic, Kathrin Schwarte (Münster/DE) Oliver Ambree (Münster, Osnabrück/DE), Christi an Bürger, Vladislava Falcone Katharina Seiler, Mehrdad Rahbar Kooybaran, Laura Grosse, Fernand Roos Julia Scheff er, Silke Jörgens, Katja Koelkebeck, Udo Dannlowski, Volker Arolt (Münster/DE) Stefanie Scheu (Düsseldorf/DE), Judith Alferink (Münster/DE) P163 Indoleamine 2,3-Dioxygenase (Ido1) Acti vity is increased in early chronic phase chronic Myelogenous Leukemia (Cml) and predicts molecular response to niloti nib therapy Sieghart Sopper (Innsbruck/AT), Satu Mustjoki (Helsinki/FI), Simon Geisler Dietmar Fuchs, Hubertus Hackl, Zlatko Trajanoski (Innsbruck/AT) Andreas Hochhaus (Jena/DE), Dominik Wolf (Bonn/DE) P164 REAlease™ immunomagneti c separati on technology with reversible labeling for p o s i ti v e isolati on of leukocytes Philipp Steinbrueck, Zhong Yu, Ursula Bissa, Jennifer Brieden Christi an Dose (Bergisch Gladbach/DE)

Immunodefi ciency P165 STAT3 haploinsuffi ciency is associated with autosomal-dominant hyper IgE syndrome Manfred Fliegauf, Cristi na Glocker (Freiburg/DE), Shiva Saghafi (Tehran/IR) Sarah Gonschorek, Philipp Fröbel, Katrin Lammich, Jessica Rojas-Restrepo Johanna Neubauer, Alla Bulashevska (Freiburg/DE), Andre Franke Stephan Weidinger (Kiel/DE), Zahra Pourpak (Tehran/IR) Bodo Grimbacher (Freiburg/DE; London/GB) P166 A novel missense mutati on in the NADPH binding domain of CYBB abolishes the NADPH oxidase acti vity in a male primary immunodefi ciency pati ent with increased suscepti bility to infecti ons Kalsoom Kalsoom, Taj Ali Khan (Peshawar/PK), Huma Asif, Asif Iqbal (Sao Paulo/BR)

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P167 The German PID-NET Registry S. M. El-Helou, A. K. Biegner, S. Bode, S. Ehl, M. Heeg, H. Ritt erbusch, S. Rusch, R. Schmitt K. Warnatz (Freiburg/DE), N. T. Baerlecken, U. Baumann, R. Beider, D. Ernst S. Gerschmann, C. Klemann, G. Mielke, R. E. Schmidt, G. Schürmann D. Viemann (Hannover/DE), M. Albert, A. Eichinger, E. Eisl, F. Hauck, C. Klein F. Sollinger (Munich/DE), H. v. Bernuth, L. Hanitsch, R. Krüger C. Scheibenbogen (Berlin/DE), A. Avila, M. Borte, S. Borte, M. Fasshauer, A. Hauenherm N. Kellner, H. Müller, A. Ülzen (Leipzig/DE), P. Bader, S. Bakhti ar, U. Heß, J. Y. Lee R. Schubert, S. Voß, S. Zielen (Frankfurt/DE), K. Bienemann, P. Lankisch, H. J. Laws J. Neubert (Düsseldorf/DE), G. Dückers, B. Lamers, V. Langemeyer, T. Niehues (Krefeld/DE) M. Hönig, A. Schulz, K. Schwarz, S. Steinmann (Ulm/DE), D. Graf (Leipzig/DE), G. Haase J. G. Liese, H. Morbach, E. Schwaneck, H. P. Tony (Würzburg/DE), D. Föll, A. Hellige K. Masjosthusmann, M. Mohr, H. Witt kowski (Münster/DE), J. C. Fischer, C. M. Hedrich A. Rösen-Wolff , J. Roesler (Dresden/DE), U. Behrends, N. Rieber (Munich/DE) U. Schauer (Bochum/DE), C. Boesecke, D. Dilloo, A. Engelhardt, B. Hülsmann, J. Rockstroh C. Scholtes, S. Schönberger, J. C. Wasmuth (Bonn/DE), R. Handgreti nger, J. Henes, U. Holzer L. Kanz (Tübingen/DE), T. Ankermann, P. von Bismarck, S. Schreiber, R. Zeuner (Kiel/DE) H. I. Huppertz, P. Kaiser-Labusch (Bremen/DE), J. Greil, D. Jakoby A. E. Kulozik (Heidelberg/DE), N. Graf, S. Heine (Homburg/DE), B. Garwer, R. Kobbe K. Lehmberg, I. Müller, (Hamburg-Eppendorf/DE), F. Herrmann, G. Horneff , A. Klein J. Peitz, N. Schmidt (St. Augusti n/DE), K. Apel, S. Bielack, U. Groß-Wieltsch (Stutt gart/DE) P. Deutz, L. Lassay, D. Kamitz, A. Sti enen, K. Tenbrock, N. Wagner (Aachen/DE) C. F. Classen (Rostock/DE), M. Weiß (Cologne/DE), B. Bernbeck, B. Brummel E. Lara-Villacanas, E. Münstermann, D. Schneider, N. Tietsch M. Westkemper (Dortmund/DE), N. Naumann-Bartsch, M. Metzler B. Sobik (Erlangen/DE), I. Kühnle, S. Kullmann, C. Kramm (Götti ngen/DE) H. Girschick (Berlin/DE), S. Elbe, C. Specker, L. Vinnemeier-Laubenthal (Essen/DE) H. Haenicke, C. Schulz, L. Schweigerer (Berlin-Buch/DE), T. G. Müller (Halle/DE), G. Kindle B. Grimbacher (Freiburg/DE) P168 Haploinsuffi ciency of NF-κB1 subunit p50 in a CVID-aff ected family Claudia Schröder, Faranaz Atschekzei (Hannover/DE), Manfred Fliegauf (Freiburg/DE) Torsten Witt e, Roland Jacobs, Thilo Dörk (Hannover/DE), Bodo Grimbacher (Freiburg/DE) Reinhold E. Schmidt (Hannover/DE) P169 Development of mature B cells lacking B cell receptor expression in a pati ent with agammaglobulinemia Tina Emler, Oliver Andres, Stephan Rauthe, Klaus Schwarz, Christoph Klein, Johannes Liese Henner Morbach (Würzburg/DE) P170 Measurement of STAT1 and STAT3 phosphorylati on by Flow Cytometry and clinical indicati ons Michael Bitar, Andraes Boldt, Stefanie Binder, Michael Borte (Leipzig/DE) Karim Kentouche (Jena/DE), Stephan Borte, Ulrich Sack (Leipzig/DE) P171 Assessing functi onal relevance of novel disease-associated mutati ons in a TNF superfamily member in pati ents with common variable immunodefi ciency Zoya Eskandarian, Alla Bulashevska, Manfred Fliegauf, Michele Proietti , Klaus Warnatz Cristi an Roberto Smulski, Hermann Eibel, Bodo Grimbacher (Freiburg/DE) P172 Identi fi cati on of heterozygous Nfk b1 variants in cvid cohort using targeted next generati on sequencing Faranaz Atschekzei, Claudia Schröder, Torsten Witt e (Hannover/DE) Bodo Grimbacher (Freiburg/DE), E. Reinhold Schmidt (Hannover/DE) 62 P�� I • W��, 13 S�� • 13:30–15:30

Infecti on I P173 Human cytomegalovirus-induced degradati on of CYTIP modulates dendriti c cell adhesion and migrati on Linda Grosche, Christi na Draßner, Petra Mühl-Zürbes, Lisa Kamm (Erlangen/DE) Vu Thuy Khanh Le-Trilling, Mirko Trilling (Essen/DE), Alexander Steinkasserer Christi ane S. Heilingloh (Erlangen/DE) P174 H.pylori and S.mansoni – promiscuity of anti gen specifi c cells and the advantages of keeping old friends Sonakshi Bhatt acharjee, Eva Loff redo Verde, Raquel Mejias-Luque,Raphaela Semper Markus Gerhard, Clarissa Prazeres da Costa (Munich/DE) P175 Gut microbial translocati on corrupts myeloid cell functi on to control bacterial infecti on via the IFN-IL-10 axis Carl-Philipp Hackstein, Lisa Marike Assmus, Marc Beyer, Joachim Schulze Jonel Trebicka, Christi an Kurts, Wolfgang Kastenmüller (Bonn/DE) Percy A. Knolle (Bonn, Munich/DE), Zeinab Abdullah (Bonn/DE) P176 Characterizing innate immune cell acti vati on by fungal pathogens using live cell imaging Alessandra Marolda, Kersti n Hünninger, Naim Al-Zaben, Marc Thilo Figge Oliver Kurzai (Jena/DE) P177 Forensic immunology for the assessment of the source of HIV-1infecti on in transmission pairs Thomas Harrer, Katja Maurer, Sandra M. Müller-Schmucker, Silke Bergmann Jennifer Etschel, Bernd M. Spriewald, Ellen Harrer (Erlangen/DE) P178 The major immediate-early protein IE2 of human cytomegalovirus is suffi cient to induce proteasomal degradati on of CD83 on mature dendriti c cells Christi ane Heilingloh, Linda Grosche, Mirko Kummer, Petra Mühl-Zürbes, Lisa Kamm Myriam Scherer, Melanie Latzko, Thomas Stamminger Alexander Steinkasserer (Erlangen/DE) P179 Infl uenza virus co-infecti on impairs control of Mycobacterium tuberculosis and increases infl ammati on and immunopathology in the lungs Sarah Ring, Lars Eggers (Borstel/DE), Gülsah Gabriel (Hamburg/DE) Bianca Schneider (Borstel/DE) P180 Functi onal analysis of lymphotoxin β receptor-regulated eff ector molecules during the immune response against intracellular pathogens Anne Wichert, Ursula Sorg, Daniel Degrandi, Kristi na Behnke, Helmut Gabbert Klaus Pfeff er (Düsseldorf/DE) P181 Consequences of constant STAT6 signaling in macrophages and epithelial cells during helminth infecti on Christoph Koch, Branislav Krljanac, Manuel Ott e, David Vöhringer (Erlangen/DE) P182 Identi fi cati on of naturally presented T cell epitopes using an HCMV deleti on virus model Maren Lübke, Stefanie Souczek, Annika Nelde, Daniel J. Kowalewski (Tübingen/DE) Hartmut Hengel, Anne Halenius (Freiburg/DE), Stefan Stevanovic (Tübingen/DE) P183 Regulati on of type 2 immunity by IL-4/IL-13 secreti on from ILC2 and their functi onal modulati on by the killer cell lecti n-like receptor 1 Cornelia Symowski, David Vöhringer (Erlangen/DE) P184 Semaphorin 3E regulates both innate and adapti ve immune response in Lipopolysaccharide induced sepsis Ifeoma Okwor, Ashfaque Mohamed, Lianyu Shan, Abdelilah S. Gounni (Winnipeg/CA)

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P185 Eff ect of the Thymus vulgaris L. (thyme) extract and phytocompound thymol in the control of in vitro infecti on by Candida albicans in murine macrophages (RAW 264.7) Jonatas Rafael de Oliveira, Leandro Wagner Figueira, Fábia Lugli Sper Vanessa Marques Meccatti , Samira Esteves Afonso Camargo Luciane Dias de Oliveira (São José dos Campos/BR) P186 Infl ammatory monocytes are controlled by classical IL-6 signalingduring Listeria monocytogenes infecti on Karsten Lücke, Isabell Yan, Sonja Krohn, Annika Volmari, Stefanie Klinge Joanna Schmid, Valéa Schumacher, Oliver M. Steinmetz, Stefan Rose-John Hans-Willi Mitt rücker (Hamburg/DE) P187 Anti gen specifi city of the adapti ve immune response against helminths Natalie Thuma, David Vöhringer (Erlangen/DE) P188 Tyrosine kinases control growth of intracellular Mycobacterium tuberculosis in human macrophages despite profound T-cell inhibiti on Stephanie Kallert, Jan Kubis, Andreas Zimmermann (Ulm/DE), Heiko Bruns (Erlangen/DE) Daniel Mayer, Mark Grieshober, Steff en Stenger (Ulm/DE) P189 Linking TNF receptor signaling in virus-infected hepatocytes to celldeath for immune control of liver infecti on Sandra Kurz, Marianne K. Janas, Annika Schneider, Kersti n Lohr, Jennifer Wett marshausen Fabiana Perocchi, Percy A. Knolle, Dirk Wohlleber (Munich/DE) P190 The role of tumor-induced neutrophil polarizati on in anti -P.aeruginosa immunity Ekaterina Pylaeva, Ilona Spyra, Sharareh Bordbari, Stephan Lang Jadwiga Jablonska (Essen/DE) P191 Successful treatment of rituximab refractory, lyti c Epstein-Barr virus disease aft er allogeneic stem cell transplantati on using pepti de sti mulated, donor-derived E B V - s p e c i fi c T-cells Lisa Meintker, Wolf Rösler, Regina Gary, Anita Kremer, Michael Aigner, Stephanie Moi Stefanie Schaff er, Heidi Balzer, Robert Zimmermann, Julian Strobel, Jürgen Zingsem Andreas Mackensen (Erlangen/DE), Armin Gerbitz (Berlin/DE) P192 Treatment with azithromycin clears respiratory infecti on with Bordetella pertussis and att enuates innate and adapti ve immune response in a mouse model Lisa Borkner, Kingston H. G. Mills (Dublin/IE) P193 The role of SAMHD1 in retroviral restricti on and sensing in mice Alexandra Herrmann (Erlangen/DE), Rayk Behrendt (Dresden/DE) Sabine Witt mann (Erlangen/DE), Axel Roers (Dresden/DE) Thomas Gramberg (Erlangen/DE) P194 CRISPR/Cas9 genome editi ng using gold nanoparti cle-mediated laserporati on Berislav Bosnjak, Marc Permanyer Bosser, Maya K. Sethi, Melanie Galla, Tobias Maetzig Dag Heinemann, Stefani Willenzon, Reinhold Förster, Alexander Heisterkamp Stefan Kalies (Hannover/DE) P195 High salt conditi ons enhance the anti bacterial acti vity of macrophages in an NO-independent manner Patrick Neubert, Andrea Weichselbaum, Valenti n Schatz, Carmen Reiti nger Agnes Schröder, Jonathan Jantsch (Regensburg/DE) P196 Pepti doglycan recogniti on protein 2 knockout alters the innate immune response in mice and cause early death in Streptococcus pneumoniae lung infecti on Alexander Dabrowski, Ulrike Behrend, Anshu Shrivastav, Claudia Conrad (Berlin/DE) Nelli Baal, Holger Hackstein (Giessen/DE), Corinne Gurtner, Kristi na Dietert Achim Gruber, Sahar Aly, Katrin Reppe, Norbert Sutt orp, Janine Zahlten (Berlin/DE) 64 P�� I • W��, 13 S�� • 13:30–15:30

P197 Use of a new proliferati on reporter system to dissect the impact of the immune response on S. aureus proliferati on Elena A. Haas (Magdeburg/DE), Eva Medina (Braunschweig/DE) P198 The cell type specifi c role of IRF-1 during C. rodenti um-induced murine intesti nal infl ammati on Angelika Schmalzl, Stefan Wirtz (Erlangen/DE) P199 T cell responses to a commensal pathogen – (re-)balancing of T cell memory to Staphylococcus aureus by mode of anti gen delivery Julia Uebele, Christoph Stein (Langen/DE), Minh-Thu Nguyen Friedrich Götz (Tübingen/DE), Isabelle Bekeredjian-Ding (Langen/DE) P200 Chronic helminth infecti on during pregnancy epigeneti cally reprograms murine T cell diff erenti ati on Clarissa Parzeres da Costa, Kathrin Klar, Sophie Perchermeier, Matt Lacorcia (Munich/DE) P202 In vivo biosensors for pathogen viability and proliferati on reveal modes of containment that are dependent on the amplitude of immune acti vati on Pauline Formaglio, Sandrina Heyde (Magdeburg/DE), Philippe Bousso (Paris/FR) Andreas J. Müller (Magdeburg, Braunschweig/DE) P203 Protecti ve role of Annexin A1 pre-treatment in host defense against IAV Sebasti an Schloer, Dörthe Masemann, Christi na Ehrhardt, Stephan Ludwig Volker Gerke, Ursula Rescher (Münster/DE) P204 Dual role of the mycobacterial cord factor TDM in cross-regulati on of macrophage responses to IFNγ Barbara Killy, Alexandra Huber, Arif Ekici, Stefan Wirtz (Erlangen/DE) Alexander Dalpke (Heidelberg/DE), Roland Lang (Erlangen/DE) P205 Macrophage diff erenti ati on by corti sone – comparati ve studies with neonatal and adult monocytes Stephan Dreschers, Kim Ohl, Klaus Tenbrock, Thorsten Orlikowsky (Aachen/DE) P206 Producti on of monoclonal anti bodies that target Enterococcus faecalis polysaccharides Ermioni Kalfopoulou, Felipe Romero-Saavedra, Diana Laverde Johannes Huebner (Munich/DE)

Innate Receptors and Sensors P237 USP13 negati vely regulates anti viral responses by deconjugati ng K27-linked ubiquiti nati on of MITA/STING Bo Zhong (Wuhan/CN) P239 Innate recogniti on and inﬂ ammasome acti vati on in human myeloid immune cells by methanogenic archaea Tim Vierbuchen (Borstel/DE), Corinna Bang (Kiel/DE), Hanna Rosigkeit (Borstel/DE) Ruth Schmitz-Streit (Kiel/DE), Holger Heine (Borstel/DE) P240 Inhibiti on of ATP-induced monocyti c interleukin-1β release by canonical and novel non-canonical cholinergic agonists depends on diﬀ erent combinati ons of nicoti nic acetylcholine receptor subunits α7, α9 and α10 Katrin Richter, Anna Zakrzewicz, Alisa Agné, Sigrid Wilker, Kathrin Siebers Bijan Fink (Giessen/DE), Gabriela Krasteva-Christ (Giessen, Homburg/DE) Mike Althaus (Giessen/DE; Newcastle upon Tyne/GB), Winfried Padberg (Giessen/DE) Arik J. Hone, J. Michael McIntosh (Salt Lake City, UT/US), Veronika Grau (Giessen/DE)

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P241 Identi ﬁ cati on of an opti mized 2”-O-methylated tri-nucleoti de RNA moti f inhibiti ng Toll-like receptor 7 and 8 Felix Schmitt , Isabel Freund, Markus Weigand (Heidelberg/DE) Mark Helm (Mainz/DE), Alexander Dalpke, Tatjana Eigenbrod (Heidelberg/DE) P243 S. epidermidis-induced reducti on of S. aureus skin colonizati on depends on the acti vati on of Interleukin-1 receptor-induced innate immune signaling pathways Katharina Bitschar, Laura Klink, Birgit Schitt ek (Tübingen/DE) P244 Inhibiti on of Mincle expression by IL-4 – A possible mechanism of phagocyte control in TH2 responses? Judith Schick, Roland Lang, Thomas Hupfer (Erlangen/DE) P245 Toll like Receptor 3 Ligand induces Apoptosis and Necroptosis in presence of CHX and TWEAK Mohamed Mohamed, Daniela Siegmund, Harald Wajant (Würzburg/DE) P246 The AhR pathway aﬀ ects cytokine responses and trained immunity but not LPS tolerance Fabian Gondorf, Jessica König, Salie Maasewerd, Dominic Gosejacob, Julia Vorac Heike Weighardt, Irmgard Förster (Bonn/DE) P247 BTN3 isoforms cooperate in phosphoanti gen mediated acti vati on of Vγ9Vδ2T cells Mohindar Murugesh Karunakaran, Daniel Palett a, Lisa Starick Ingolf Berberich (Würzburg/DE), Marco J Herald (Parkville/AU) Thomas Herrmann (Würzburg/DE) P248 Functi onal and molecular conservati on of acti vati on ofγδ T cells by phosphorylated metabolites between humans and the new world camelid alpaca (Vicugna pacos) Alina Fichtner, Mohindar Murugesh Karunakaran, Lisa Starick (Würzburg/DE) Thomas Goebel (Munich/DE), Thomas Herrmann (Würzburg/DE) P249 Patt ern recogniti on of immune cells (PRI) – how to get more out of your multi -parametric cytometry data Yen Hoang, Stefanie Gryzik, Timo Lischke, Isabelle Kadner (Berlin/DE) Detlef Groth (Potsdam/DE), Ria Baumgrass (Berlin/DE)

Microbiome and Immunity P250 Impact of microbial colonisati on on the immune cell compositi on and barrier functi on in the gut Franziska Schmidt (Berlin/DE), Katja Dahlke (Nuthetal/DE), Arvind Batra, Jacqueline Keye Hao Wu, Marie Friedrich, Rainer Glauben (Berlin/DE), Christi ane Ring (Nuthetal/DE) Gunnar Loh (Karlsruhe/DE), Monika Schaubeck (Planegg-Marti nsried/DE) Thomas Clavel (Aachen/DE), Michael Schumann, Anja Kühl (Berlin/DE) Michael Blaut (Nuthetal/DE), Britt a Siegmund (Berlin/DE) P251 Analysis of the gut microbiome in Foxp3+ regulatory T cell depleted mice Davina Schoemer, Alexandra Adamczyk, Eva Pasti lle, Astrid Westendorf, Jan Buer Jan Kehrmann (Essen/DE) P252 The role of altered microbiota in PSC-associated coliti s Simon Bohmann, Tanja Bedke, Cathleen Haueis, Nicola Gagliani Samuel Huber (Hamburg/DE) P253 Commensal bacteria-derived metabolite pentanoate protects against T cell-mediated immunopathology Maik Luu, Elena Jenike, Agnieszka Zarzycka, Ulrich Steinhoﬀ Alexander Visekruna (Marburg/DE)

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P254 Dietary tryptophan depleti on inhibits infi ltrati on of autoreacti ve T cells into the central nervous system (CNS) Jana Katherina Sonner, Melanie Keil (Heidelberg/DE), Maren Falk-Paulsen Richa Bharti (Kiel/DE), Iris Oezen, Katrin Deumelandt (Heidelberg/DE) Anupam Sinha (Kiel/DE), Hendrik Wolff (Frankfurt/DE) Magdalena Kramer (Heidelberg/DE), Florian Wanke, Yilang Tang, Ines Brando Christoph Reinhardt, Florian Kurschus (Mainz/DE), Jürgen Okun, Wolfgang Wick Michael Platt en (Heidelberg/DE) P255 The gut microbiota mediates clearance of intesti nal C. rodenti um infecti on through acti vati on and homing of neutrophils into the gut lumen Ulrich Steinhoff , Agnes Zarzyka, Rossana Romero, Florence Fischer, Hans Mollenkopf Alexander Visekruna (Marburg/DE) P256 The impact of dietary fi ber on intesti nal microbiota and homeostasis Florence Fischer, Ulrich Steinhoff , Alexander Visekruna (Marburg/DE) Hans-Joachim Mollenkopf (Berlin/DE) P257 Role of the microbiome in CD4+ T cell mediated liver injury Birgit Schiller, Claudia Wegscheid, Laura Berkhout (Hamburg/DE), Agnieszka Zarzycka Ulrich Steinhoff (Marburg/DE), Nicole Fischer, Gisa Tiegs (Hamburg/DE) P258 Short chain fatt y acids are potent regulators of systemic bone mass and protect for pathological bone loss by inhibiti ng osteoclasts Sébasti en Lucas, Yasunori Omata, Marti n Bött cher, Jörg Hofmann, Brenda Krishnacoumar Gerhard Krönke, Dimitrios Mougiakakos (Erlangen/DE), Aida Iljazovic (Braunschweig/DE) Uwe Sonnewald (Erlangen/DE), Till Strowig (Braunschweig/DE), Georg Schett Mario Zaiss (Erlangen/DE) P259 Identi fi cati on of new natural products with anti -microbial acti vity against api-complexa and multi resistant gram-negati ve rods Shabnam Shaneh Sazzadeh, Sarah Schmidt, Karin Buchholz, Peter Proksch Klaus Pfeff er (Düsseldorf/DE) P260 mGBPs and interacti ng proteins in host defense Larissa Legewie, N. Steff ens, E. Kravets, D. Degrandi, K. Pfeff er (Düsseldorf/DE)

NK Cells & other Innate Immune Cells I P274 Investi gati on on the suppressive eff ect of AML blasts on NK cells Tobias Baumann, Christi na Krupka, Betti na Lindl, Percy A. Knolle, Marion Subklewe Basti an Höchst (Munich/DE) P275 The chemokine receptor CCR8 in migrati on and eff ector functi on of innate lymphoid cells type 2 Lisa Knipfer, Markus Kindermann, Tatjana Primbs, David Vöhringer, Markus F. Neurath Stefan Wirtz (Erlangen/DE) P276 Qualitati ve and quanti tati ve analysis of PMN/T-cell interacti ons by InFlow and super-resoluti on microscopy Emre Balta, Julian Stopp, Laura Castelletti , Henning Kirchgessner, Yvonne Samstag Guido H. Wabnitz (Heidelberg/DE) P277 NK killing effi ciency is enhanced by non-target bystander cells Bin Qu, Xiao Zhou, Renping Zhao (Homburg/DE) Karsten Schwarz (Saarbrücken/DE), Matt hieu Mangeat (Saarbrücken/DE; Talence/FR) Eva Schwarz (Homburg/DE), Mohamed Hamed (Saarbrücken, Rostock/DE) Ivan Bogeski (Homburg, Götti ngen/DE), Volkhard Helms, Heiko Rieger (Saarbrücken/DE) 67 P�� I • W��, 13 S�� • 13:30–15:30

P278 The conversion from eﬀ ector NK cells to tumor-induced memory-like NK cells Lisa Schwab, Marina Pal, Vanessa Borgmann, Maya C. André (Tübingen/DE) P279 ILC2s functi on as criti cal regulators of early anti -cryptococcal immune responses Markus Kindermann, Lisa Knipfer, Tatjana Primbs, David Vöhringer, Markus Neurath Stefan Wirtz (Erlangen/DE)

P280 Investi gati ons on the infl uence of the atypical NF-κB inhibitor protein IκBNS on NK cell-mediated immune responses within a Listeria monocytogenes infecti on Martha Böning, Sarah Frentzel (Magdeburg/DE) Ingo Schmitz (Braunschweig, Magdeburg/DE), Andreas Jeron (Magdeburg/DE) Dunja Bruder (Magdeburg, Braunschweig/DE) P281 Fatt y acid oxidati on compensates for LPS-induced Warburg eff ect in glucose-deprived monocytes Nora Raulien, Kathleen Friedrich, Sarah Strobel, Stefan Rubner, Sven Baumann Marti n von Bergen, Antje Körner, Marti n Krüger, Manuela Rossol, Ulf Wagner (Leipzig/DE) P282 Introducti on of 2D human leucocyte migrati on assays suited for the applicati on in the clinical setup Lea Bornemann, Charlyn Sobczak, Karl-Heinz Jöckel, Joachim Göthert, Marc Schuster Matt hias Gunzer (Essen/DE) P283 Androgens promote an il10/tgfb -expressing neutrophil immunomodulatory phenotype Maria Victoria Scalerandi, Carolina Leimgruber, Juan Pablo Nicola Nahuel Peinetti Cuello Rubio Mariana (Cordoba/AR), Oliver Soehnlein (Munich/DE) Gustavo B Menezes (Belo Horizonte/BR), Cristi na Maldonado Amado Quintar (Cordoba/AR) P285 Human NK cells from alloSCT pati ents show reduced acti vity against A. fumigatus compared to NK cells from healthy donors Lothar Marischen, Anna-Lena Schmitt , Anne Englert, Esther Weiß (Würzburg/DE) Kersti n Hünniger (Jena/DE), Oliver Kurzai, Hermann Einsele, Jürgen Löffl er (Würzburg/DE) P286 Individual NK cell immunity in HCV pati ents under DAA therapy Wenjie Bi, Maxi Heyner (Braunschweig/DE), Julia Hengst (Hannover/DE) Frank Klawonn (Braunschweig/DE), Heiner Wedemeyer (Hannover/DE) Lothar Jänsch (Braunschweig/DE) P287 A two-phase expansion protocol combining IL-15 and IL-21 improves NK Cell proliferati on and cytotoxicity against rhabdomyosarcoma Juliane Wagner, Viktoria Pfannensti el, Anja Waldmann, Winfried Wels, Peter Bader Evelyn Ullrich (Frankfurt/DE) P288 NK Cell anti -tumor effi cacy in multi ple myeloma pati ents before and aft er autologous stem cell transplantati on Sara Tognarelli, Ivana von Metzler, Bushra Rais (Frankfurt/DE) Benedikt Jacobs (Oslo/NO; Erlangen/DE), Peter Bader, Hubert Serve (Frankfurt/DE) Andreas Mackensen (Erlangen/DE), Evelyn Ullrich (Frankfurt/DE)

T Cells I P347 Moringa oleifera Lam. leaves extract reduces human T cell hyporesponsiveness and DNA damage induced by oxidati ve stress Kanchana Usuwanthim (Pithsanulok/TH) P348 Circadian regulati on of the adapti ve immune response Louise Ince, David Druzd, Wenyan He, Chien-Sin Chen, Ute Harrison (Munich/DE) Ling Yao (Berlin/DE), Naoto Kawakami (Munich/DE), Leif Erik Sander (Berlin/DE) Rainer Haas, Christoph Scheiermann (Munich/DE) 68 P�� I • W��, 13 S�� • 13:30–15:30

P349 T-cell and Interleukins-2 Receptors in Bronchial Asthmati c Children Laila Damanhouri (Jeddah/SA) P350 Sequence-functi on analysis of three T-cell receptors targeti ng theHIV-1 p17 epitope SLYNTVATL Christi ane Mummert, Christi an Hofmann, Angela G. Hückelhoven, Silke Bergmann Sandra M. Müller-Schmucker, Ellen G. Harrer, Jan Dörrie, Niels Schaft Thomas Harrer (Erlangen/DE) P351 RBPJ expression in regulatory T cells is criti cal for restraining TH2 responses Michael Delacher (Heidelberg/DE), Yonatan Herzig (Rehovot/IL), Fabian Brunk Danny Kägebein, Ulrike Träger, Ann-Cathrin Hofer, Achim Breiling Thomas Hielscher (Heidelberg/DE), Roland Schmid (Munich/DE), Guiseppina Federico Hermann-Josef Gröne (Heidelberg/DE), Jakub Abramson (Rehovot/IL) Markus Feuerer (Heidelberg/DE) P352 TCR signal strength modulated by microRNA miR-181a/b-1 imposes adevelopmental legacy on peripheral Treg cell functi on Natalia Zietara, Marcin Lyszkiewicz (Hannover, Munich/DE) Samantha Winter (Frankfurt/DE), Katrin Witzlau (Hannover/DE) Esther Imelmann (Frankfurt/DE), Akihiko Yoshimura (Tokyo/JP) Jochen Huehn (Braunschweig/DE), Immo Prinz (Hannover/DE) Siegfried Weiss (Hannover, Braunschweig/DE), Andreas Krueger (Frankfurt, Hannover/DE) P353 Dual pulse labeling using nucleoside analogues for cell cycle analysis of thymocytes Heike Kunze-Schumacher (Frankfurt/DE), Jonas Blume (Victoria/AU) Esther Imelmann, Andreas Krueger (Frankfurt/DE) P354 Reacti vati on of bone marrow resident memory CD4 T cells in immune niches of the bone marrow Francesco Siracusa, Mairi McGrath, Patrick Maschmeyer, Markus Bardua, Katrin Lehmann Gitt a Heinz, Pawel Durek, Frederik F. Heinrich, Mir-Farzin Mashreghi, Hyun-Dong Chang Koji Tokoyoda, Andreas Radbruch (Berlin/DE) P355 Profi lin 1 reduces CTL migrati on and survival under high tension Renping Zhao, Rouven Schoppmeyer, Xiao Zhou, Yan Zhou, Eva Schwarz Bin Qu (Homburg/DE) P356 MAIT cells – a new player in anti fungal immunity against Aspergillus fumigatus? Susanne Jahreis, Tobias Rachow, Silke Rummler, Andreas Hochhaus Marie von Lilienfeld-Toal (Jena/DE) P357 Bacteria-specifi c CD4+ T-cell responses of neonates, infants and dults show age-dependent characteristi cs Katrin Vogel, Franziska Braun, Mandy Pierau, Karin Lampe, Gerhard Jorch, Dirk Schlüter Christoph Arens, Monika C. Brunner-Weinzierl (Magdeburg/DE) P358 Eugenol regulates the balance between Th1-Th2 and Th17-Treg cytokines in collagen induced arthriti s Shaguft a Moin, Somaiya Mateen, Abul Faiz Faizy, Kafi l Akhtar Shahida Perween (Aligarh/IN) P359 Eff ects of extracorporeal photopheresis on monocytes and lymphocytes in an in vitro assay Franziska Wiese, Katharina Reinhardt-Heller, Ursula Holzer (Tübingen/DE) P360 MicroRNAs are essenti al for the maintenance of Tfh cell identi ty and germinal centers Julia Maul, Julia Niemitz, Frank Dahlström, Dirk Baumjohann (Planegg-Marti nsried/DE) P361 Neuropilin-1 and its role in intratumoral CD4+ T cell functi on Romy Barthel, Jan Buer, Wiebke Hansen (Essen/DE) 69 P�� I • W��, 13 S�� • 13:30–15:30

P362 How are resti ng memory Th cells generated? Jana Sarkander, Shintaro Hojyo, Mathias Mursell, Tsung Yen Wu, Koji Tokoyoda (Berlin/DE) P363 Identi fi cati on of cytokines criti cal for the maintenance of memory T helper cells Mathias Mursell, Shintaro Hojyo, Jana Sarkander, Tsung Yen Wu (Berlin/DE) Koichi Ikuta (Kyoto/JP), Toshinori Nakayama (Chiba/JP), Andreas Radbruch Koji Tokoyoda (Berlin/DE) P364 CD83 modulates regulatory T cell development Marina Döbbeler, Matt hias Lechmann, Alexander Steinkasserer Christi na König (Erlangen/DE) P365 The role of acid sphingomyelinase in T cell responses Matt hias Hose, Astrid Westendorf, Jan Buer, Wiebke Hansen (Essen/DE) P366 Characterizati on of the γδ-T-cell-mediated immune control in mCMV infecti ons Anne Maria Hahn, Sabrina Sell, Monika Dietz, Andrea Schneider, Michael Mach Thomas Winkler (Erlangen/DE) P367 T cell specifi c CD83 defi ciency correlates with increased CD4+ T cell acti vati on Katarina Liedtke, Wiebke Hansen (Essen/DE) P368 Staphylococcus aureus-derived proteins directly modulate CD4+ T cells Agnes Bonifacius (Braunschweig/DE), Silva Holtf reter, Barbara Broeker (Greifswald/DE) Stefan Floess, Jochen Huehn (Braunschweig/DE) P369 Dynein light intermediate chain 1 (LIC1) in T cell signalling and immunological synapse organisati on of Tregs Nicole Amsberg, Marco van Ham (Braunschweig/DE), Stefanie Kliche, Lars Philipsen Andreas Müller (Magdeburg/DE), Christi ne Falk (Hannover/DE), Jochen Hühn Lothar Jänsch (Braunschweig/DE)

P370 IκBNS is involved in the early stages of TΗ1 diff erenti ati on, but is not necessary for the functi on of terminally diff erenti ated cells Konstanti nos Katsoulis-Dimitriou, Carlos Plaza-Sirvent Ingo Schmitz (Braunschweig, Magdeburg/DE) P371 Functi onal acti vati on of T-cells by Jak2V617F Sissy Just, Gopala Krishna Nishanth, Denise Wolleschak, Corinna Fahldieck Thomas Fischer (Magdeburg/DE), Ann Mullally (Boston, MA/US) Florian Perner (Magdeburg, Jena/DE), Tina M. Schnöder, Florian H. Heidel (Jena/DE) Dirk Schlüter (Magdeburg, Braunschweig/DE) P372 Characterizati on of DUB-2 expression and its T cell-specifi c functi on Josephin Koschel, Gopala Krishna Nishanth, Sissy Just, Dirk Schlüter (Magdeburg/DE) P373 CD28 co-sti mulati on of memory CD4+ Th1 cells triggers IFNg secreti on in vivo Stephanie Haack, Daniela Langenhorst (Würzburg/DE), Fred Lühder (Götti ngen/DE) Thomas Hünig, Niklas Beyersdorf (Würzburg/DE) P374 Modulati on of the immune response via the HVEM network in experimental malaria Franziska Muscate, Nadine Stett er, Thomas Jacobs (Hamburg/DE) P375 Histone H2A deubiquiti nase Mysm1 in T helper cell development and autoimmunity Ioanna Krikki, Marti na Gatzka (Ulm/DE) P376 Interleukin-21 mediates immunometabolic eff ects in T cell Romy Loschinski, Marti n Bött cher, Domenica Saul, Heiko Bruns, Regina Jitschin Andreas Mackensen, Dimitrios Mougiakakos (Erlangen/DE) P377 Immunosuppressive eff ects of sulforaphane on primary human T cells Jie Liang, Beate Jahraus, Guido Wabnitz, Henning Kirchgessner, Emre Balta Christi an Orlik, Yvonne Samstag (Heidelberg/DE)

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P378 Comparison of regulatory properti es of CD4+ PD1+ T cells from malaria pati ents and healthy donors Lea Kaminski, Frederik Bitzer, Annemieke Abel, Thomas Jacobs Maria Sophia Mackroth (Hamburg/DE) P379 B cells infl uence on an environmental cue for IL-2-dependent generati on of resti ng memory T helper cells Shintaro Hojyo, Jana Sarkander, Tsung-Yen Wu, Mathias Mursell, Andreas Radbruch Max Löhning, Koji Tokoyoda (Berlin/DE) P380 Foxo1-dependent metabolic programming of liver-primed memory CD8+ T cells Michael Dudek (Munich/DE) P381 Anti gen-specifi c inducible Treg and not natural Treg tolerize autoreacti ve B cells via PD-L1 Ermanila Dhana, Janine Gotot (Bonn/DE), Hideo Yagita (Tokyo/JP), Isis Ludwig-Portugall Christi an Kurts (Bonn/DE) P382 NFATc1 Controls the Cytotoxicity of CD8+ T cells Stefan Klein-Hessling, Khalid Muhammad, Matt hias Goebeler, Andreas Kerstan Edgar Serfl ing (Würzburg/DE) P383 Repeti ti ve isolati on and transfer of proliferati ve eff ector CD8+ T cells from a single donor Lucas Ott ,o Gennadiy Zelinskyy, Marc Schuster, Ulf Ditt mer, Matt hias Gunzer (Essen/DE) P384 Identi fi cati on of subsets of terminally diff erenti ated eff ector CD8+ T cells (TEMRA) by mass cytometry (CyTOF) lisa Burkhardt, Iuliia Kotko, Stefan Schlickeiser, Desiree Kunkel, Karsten Jürchott Caroline Baumann, Hans-Dieter Volk (Berlin/DE) P385 Evidence of direct platelet – T-cell cross-talk in systemic autoimmune vasculiti s Anja Kerstein, Silke Pitann (Lübeck/DE), Sebasti an Klapa (Kronshagen/DE), Ralph Pries Barbara Wollenberg, Antje Müller, Gabriela Riemekasten, Peter Lamprecht (Lübeck/DE) P386 T cell quorum-sensing upon infecti on – A rheostat for balanced immune responses? Braun Julia, Simon Zenke, Peter Aichele (Freiburg/DE), Monika Wolkers (Amsterdam/NL) Joost Beltman (Leiden/NL), Ton Schumacher (Amsterdam/NL), Jan Rohr (Freiburg/DE)

P387 A novel pathway for the regulati on of ti ssue resident memory T cells (TRM) by ti ssue damage Regina Stark, Tom Wesselink, Felix M. Behr, Natasja A. M. Kragten (Amsterdam/NL) Friedrich Koch-Nolte (Hamburg/DE), Klaas P. J. M. van Gisbergen Rene A. W. van Lier (Amsterdam/NL) P388 A role for SLy1 in T-ALL development Daniel Schäll, Jackson Brougher, Sandra Beer-Hammer (Tübingen/DE) P389 The impact of Yersinia pseudotuberculosis and its derived proteins on the stability of regulatory T cells Ahmed ElFiky, Agnes Bonifacius, Pooja Sadana, Maria Pimenova, Paweena Chaoprasid Andrea Scrima, Petra Dersch, Maria Pasztoi, Jochen Huehn (Braunschweig/DE) P390 Modulati on of human conventi onal and regulatory T cells by pharmacological inhibiti on of the acid sphingomyelinase in vitro Fabio Dennstädt, Claudia Hollmann, Teresa Wiese, Saskia Stonawski Catherina Wurst (Würzburg/DE), Mathias Butt mann (Bad Mergentheim, Würzburg/DE) Andreas Menke, Jürgen Schneider-Schaulies, Niklas Beyersdorf (Würzburg/DE) P391 Mobilizati on of human ti ssue-resident memory T cells in response to systemic re-challenges Carla Cendón, Tobias Alexander, Anne Bruns, Axel Schulz, Ana Rao, Simon Reinke P von Roth, G Wassilew, Antje Blankenstein, Thomas Dörner, Farzin Mashreghi Hyun-Dong Chang, Andreas Radbruch, Jun Dong (Berlin/DE) 71 P�� I • W��, 13 S�� • 13:30–15:30

P392 TCR signal quality modulates fate decisions of single CD4+ T cells in a probabilisti c manner Yi-Li Cho, Michael Flossdorf, Lorenz Kretschmer (Munich/DE) Thomas Höfer (Heidelberg/DE), Dirk Busch, Veit Buchholz (Munich/DE) P393 Impaired ICOS+-T-cell diff erenti ati on is involved in the Pathogenesis of preterm labor Florian Kälble, Charlott e Mai, Miriam Wagner (Heidelberg/DE) Linda Schober (Mannheim/DE), Matt hias Schaier, Marti n Zeier, Julia Spratt e Herbert Fluhr, Andrea Steinborn (Heidelberg/DE) P394 Expression of co-inhibitory molecules defi nes a regulatory T eff ector cell subset in human Plasmodium falciparum malaria Annemieke Abel, Maria Mackroth, Thomas Jacobs (Hamburg/DE)

Transplantati on P425 Graft -Versus-Host Disease (GVHD) development aft er bone marrow transplantati on is not infl uenced by TH9 cells Tanja Reisser, Sylvia Muche, Ingrid Knape, Jasmin Scheurer, Frank Leithäuser Klaus-Michael Debati n, Gudrun Strauss (Ulm/DE) P426 The sti mulatory capacity of porcine anti gen presenti ng cells can be decreased by transgenic expression of the CTLA4.Ig derivate LEA29Y Rabea Hein, Claudia Pokoyski, Wiebke Baars, Heike Düvel Reinhard Schwinzer (Hannover/DE) P427 Quanti fi cati on of specifi c T cell responses allows treatment guidance of a pediatric pati ent with sequenti al GvHD, acute rejecti on and CMV infecti on following lung transplantati on Christi ne Falk, Carsten Müller, Igor Tudorache, Wiebke Sommer, Kersti n Daemen Jana Keil, Christi ne Neudörfl , Gesine Hansen, Axel Haverich, Gregor Warnecke Nicolaus Schwerk (Hannover/DE) P428 Preservati on soluti on aff ects the immunological milieu in lung transplantati on by changing the infl ammatory balance and recruiti ng diff erent T and NK cell subsets Ramon Bellmàs Sanz, Midas Seyda, Betti na Wiegmann, Christi ne Neudörfl , Axel Haverich Gregor Warnecke (Hannover/DE), Christi ne Falk (Hannover, Braunschweig/DE) P429 Rejecti on of human kidney allograft s according to BANFF classifi cati on is associated with high CXCL9, CXCL10 but low cytokine levels in biopsy ti ssue Christi ne Neudörfl , Kersti n Daemen, Jana Keil, Frank Lehner, Jan-Hinrich Bräsen Jessica Schmitz, Hermann Haller, Cornelia Blume (Hannover/DE) Christi ne Falk (Hannover, Braunschweig/DE) P430 Preventi on of acute Graft -versus-Host disease aft er allogeneic bone marrow transplantati on by molecular targeti ng of anti -apoptoti c proteins in acti vated donor T cells Ivan Odak, Maleen Beck, Matt hias Eder, Christi an Koenecke (Hannover/DE) P431 STRIDE – Stem cell TRansplantati on in CVID with severe Immune DysrEgulati on Marta Rizzi (Freiburg/DE), Virginie Courteille, Nizar Mahlaoui (Paris/FR) Arjen Lankester (Leiden/NL), Jürgen Finke, Klaus Warnatz, Claudia Wehr (Freiburg/DE) P432 Modulati on of human anti -pig immune responses by targeti ng porcine MHC class-II and CD45 molecules Claudia Pokoyski, Britt a Trautewig, Heike Düvel, Joachim Hundrieser Reinhard Schwinzer (Hannover/DE) P433 Tracing alloreacti ve T cells from priming site to target organ during aGvHD using photoconversion Katja Ott müller, Zeinab Mokhtari, Jürgen Pinnecker, Katrin Heinze Andreas Beilhack (Würzburg/DE) 72 P�� I • W��, 13 S�� • 13:30–15:30

P434 Interferon regulatory Factor 4 in Graft -versus-Host disease Jochen Frueh, Bushra Rais, Katja Stein, Ilja Ovsiy, Franziska Ganss (Frankfurt/DE) Michael Lohoﬀ (Marburg/DE), Evelyn Ullrich (Frankfurt/DE) P435 Dynamics of Torque Teno virus viremia could predict risk of complicati ons aft er allogeneic hematopoieti c stem cell transplantati on Ramona Gilles, Marco Herling, Udo Holti ck, Eva Heger, Sabine Awerkiew, Irina Fish Konstanti n Höller, Saleta Sierra, Elena Knops, Rolf Kaiser, Christof Scheid Veronica Di Cristanziano (Cologne/DE)

Tumor Immunology & Immunotherapy I P436 Immunological basis of local and abscopal anti tumor responses induced with radio-immunotherapy Michael Rückert, Benjamin Frey, Rainer Fietkau, Udo Gaipl (Erlangen/DE) P437 Phomoxanthone A, a promising candidate in anti -cancer drug development with immunosti mulatory and selecti ve cytotoxic eff ects on primary murine immune cells Lisa Richter, Marian Frank, Philip Böhler, Björn Stork, Sebasti an Wesselborg Peter Proksch, Stefanie Scheu (Düsseldorf/DE) P438 Immune checkpoint expression on lymphocyte populati ons in head and neck cancer p a ti e n t s Lisa K. Punti gam, Sandra S. Jeske, Cornelia Brunner, Thomas K. Hoff mann Patrick J. Schuler (Ulm/DE) P439 Head and neck cancer – the infl uence of adenosine on regulatory B cells Sandra S. Jeske, Lisa K. Punti gam, Marlene Wigand, Johannes Döscher, Cornelia Brunner Thomas K. Hoff mann, Patrick J. Schuler (Ulm/DE) P440 Generati on of high-avidity, WT1-reacti ve CD8+ cytotoxic T cell clones with anti -leukemic acti vity by streptamer tecnology Rebekka Wehner, Antje Tunger (Dresden/DE), Malte von Bonin (Dresden, Heidelberg/DE) Denise Kühn, Falk Heidenreich, Sarah Matko (Dresden/DE) Magdalena Nauerth (Munich/DE), Elke Rücker-Braun, Sevina Dietz, Cornelia Link Anne Eugster, Markus Odendahl (Dresden/DE), Dirk Bush (Munich/DE) Torsten Tonn (Dresden, Heidelberg/DE), Enzio Bonifacio (Dresden/DE) Lothar Germeroth (Götti ngen/DE), Johannes Schetelig (Dresden/DE) Marti n Bornhäuser, Marc Schmitz (Dresden, Heidelberg/DE) P441 Addressing tumor associated macrophages in a humanized mouse melanoma model using small molecules and siRNA encapsulated in nanoparti cles to achieve ana n ti -tumor response Jonathan Schupp, Corinna Bächle, Matt hias Voigt, Sven Kurch, Nadine Leber Detlef Schuppan, Rudolf Zentel (Mainz/DE), Thorsten Glaser (Bielefeld/DE) Wolfgang Tremel, Mark Helm, Andrea Tuett enberg (Mainz/DE) P442 Late-onset acute graft versus host disease is associated with enhanced graft versus tumor acti vity in a new mouse model Anna Uri (Würzburg/DE), Fred Lühder (Götti ngen/DE), Thomas Hünig, Thomas Kerkau Niklas Beyersdorf (Würzburg/DE) P443 Mixed-ligand coated gold nanoparti cles to improve effi cacy of a TLR7 agonist for cancer immunotherapy Inès Mott as (Geneva, Fribourg/CH), Ahmet Bekdemir (Lausanne/CH) Alessandra Cereghetti (Fribourg/CH), Lorenzo Spagnuolo (Geneva, Fribourg/CH) Marie Müller (Lausanne/CH), Carole Bourquin (Geneva, Fribourg /CH) Francesco Stellacci (Lausanne/CH) 73 P�� I • W��, 13 S�� • 13:30–15:30

P444 Analysis of tumor-infi ltrati ng T cells made easy – complete workfl ows improve the isolati on and analysis of tumor-infi ltrati ng T cells Cesar Evaristo, Ramona Siemer, David Agorku, Janina Brauner, Olaf Hardt Christi an Dose, Anne Richter (Bergisch Gladbach/DE) P445 The phenotypic and transcriptomic landscape of tumor associated myeloid cells during primary and relapsing ovarian cancer Olympia Papantonopoulou, Thomas Ulas, Anna Doeser, Michael Mallmann Walther Kuhn (Bonn/DE), Peter Mallmann (Cologne/DE), Kristi an Haendler Joachim Schultze, Andreas Schlitzer (Bonn/DE) P446 Microbial metabolites as a source of novel regulatory T cell inhibitors Fati ma Al-Naimi (Hannover/DE), Agnes Bonifacius (Braunschweig/DE), Judith Bartel Melanie Gohmert, Maxine Swallow, Jenny Freitag (Hannover/DE) Jochen Huehn (Braunschweig/DE), Tim Sparwasser (Hannover/DE) P447 Oncometabolite D-2HG impacts both metabolism and functi on of T cells Marti n Bött cher (Erlangen/DE), Kathrin Renner (Regensburg/DE) Kristi n Mentz (Erlangen/DE), Marina Kreutz (Regensburg/DE) Andreas Mackensen, Dimitrios Mougiakakos (Erlangen/DE) P448 Therapeuti c vaccinati on using a minimal HPV16 E7 epitope in a MHC-humanized mouse model Sebasti an Kruse, Marleen Büchler, Alexandra Klevenz, Philipp Scherer, Tammy C. T. Lan Ruwen Yang, Frank Rösl, Renata Blatnik, Angelika B. Riemer (Heidelberg/DE) P449 Hodgkin lymphoma cells trigger in vitro diff erenti ati on of human monocytes into macrophages of the M2-subtype Annekatrin Arlt, Frederike von Bonin, Meike Schaff rinski (Götti ngen/DE) Tobias Pukrop (Regensburg/DE), Jörg Wilti ng, Lorenz Trümper Dieter Kube (Götti ngen/DE) P450 Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells Hao Wu (Berlin/DE), Gerald Willimsky, Qin Zhihai (Beijing/CN), Britt a Siegmund Rainer Glauben (Berlin/DE) P451 Immunomonitoring peripheral blood and plasma of malignant melanoma pati ents in the course of immunotherapy Franziska Krebs, Heidrun Mitzel-Rink, Awena Schach, Juliane Behling (Mainz/DE) Markus Meissner (Frankfurt/DE), Stefan Tenzer, Stephan Grabbe Carmen Loquai Andrea Tuett enberg (Mainz/DE) P452 Interleukin-17A promotes tumor invasiveness by inducing epithelial to mesenchymal switch and MMP-9 acti vati on in laryngeal carcinoma Nora Kariche (Algiers/DZ), Nabila Moulai (Blida/DZ), Samir Benyahia (Algiers/DZ) Wahiba Ouahioune (Blida/DZ), Djamel Djennaoui, Chafi a Touil-Boukoff a Mehdi Bourouba (Algiers/DZ) P453 The IKZF1-IRF4 axis regulates macrophage polarizati on and macrophage–mediated anti -tumor immunity Heiko Bruns, Dimitrios Mougiakakos, Christi an Bach, Leonhard Busch, Marti n Bött cher Heidi Balzer, Katrin Bitt erer, Maike Bütt ner, Kolja Gelse (Erlangen/DE), Michael Rehli Julia Wimmer (Regensburg/DE), Jan Krönke (Ulm/DE), Markus Hoff mann (Erlangen/DE) Christi an Schütz (Langen/DE), Bernd Spriewald, Andreas Mackensen (Erlangen/DE) P454 The regulatory eff ect of Type I IFNs on neutrophil angiogenic capability in tumor microenvironment Sharareh Bordbari, Ekaterina Pylaeva, Ilona Spyra, Stephan Lang Jadwiga Jablonska-Koch (Essen/DE) 74 P�� I • W��, 13 S�� • 13:30–15:30

P455 BRAF and MEK inhibitors infl uence human immune cell phenotype and functi on Stefanie Hoyer, Valenti na Eberlein, Lek Babalija, Kersti n Gerer, Lisa Walter Gerold Schuler, Niels Schaft , Lucie Heinzerling, Jan Dörrie (Erlangen/DE) P456 A new functi on for kallikrein-related pepti dases as acti vators ofchemokine CCL14 Dagmar Quandt (Halle/DE), Mario Grünberg (Köthen/DE), Holger Cynis Hans-Ulrich Demuth (Halle/DE), Wolf-Georg Forssmann (Hannover/DE) Hans-Jürgen Mägert (Köthen/DE), Barbara Seliger (Halle/DE) P458 Warburg phenotype induces high infi ltrati on of regulatory T cells in human OSCC Katrin Singer, Gerrit Spanier, Sandra Schmidhofer, Almut Brand, Katrin Peter Kathrin Renner-Satt ler, Wolfgang Herr (Regensburg/DE) Wolfgang Müller-Klieser (Mainz/DE), Torsten Reichert, Marina Kreutz (Regensburg/DE) P459 A novel mouse model for human melanoma – new possibiliti es to test immunomodulatory anti bodies in the context of a human immune system Andrea Ipsen Escobedo, Diana Dudziak, Christi an Lehmann, Nils Schaft , Jan Dörrie Stefanie Groß, Ugur Uslu (Erlangen/DE), Raphael Clynes (New York, NY/US) Falk Nimmerjahn (Erlangen/DE) P460 Blocking lactate secreti on by simultaneous inhibiti on of MCT1 and MCT4 with diclofenac preserves T cell eff ector functi ons and improves checkpoint therapy Kathrin Renner (Regensburg/DE), Holger Becker (Kaiserslautern/DE), Matt hias Fante Lisa Hacker, Christi na Bruss, Lisa Aigle, Stephanie Faerber, Katrin Singer Petra Hoff mann (Regensburg/DE), Sven Lang (Freiburg/DE) Wolfgang Herr (Regensburg/DE), Mark Selby (San Francisco, CA/US) Marina Kreutz (Regensburg/DE)

Vaccinati on P477 Inducti on of protecti ve immunity against the zoonoti c Rift Valley fever Virus by opti mised DNA vaccinati on in a rodent model and in a natural host species Chrun Tiphany, Lacote Sandra (Lyon/FR), Urien Céline (Jouy-en-Josas/FR), Barc Céline Sarradin Pierre (Nouzilly/FR), Ferrier Audrey, Peyreﬁ tt e Christophe (Bréti gny-sur-Orge/FR) Pujols Joan (Barcelona/ES), Lakhdar Lati fa, Marianneau Philippe (Lyon/FR) Schwartz Isabelle (Jouy-en-Josas/FR) P478 Intrastructural help – harnessing heterologous T helper cells induced by licensed vaccines to improve the quality of HIV-1 Env anti body responses aft er immunizati on with virus-like parti cles incorporati ng T helper cell epitopes of the heterologous a n ti g e n Hassan Elsayed (Erlangen/DE; Dokki/EG), Vladimir Temchura (Erlangen/DE) Ghulam Nabi (Bochum/DE), Matt hias Tenbusch, Klaus Überla (Erlangen/DE) P479 Characterizati on of NF-κB-opti mized dendriti c cells expressing the truncated large T anti gen of Merkel cell polyomavirus for therapeuti c vaccinati on against Merkel cell carcinoma Kersti n F. Gerer, Michael Erdmann (Erlangen/DE), Sine R. Hadrup Rikke B. Lyngaa (Copenhagen/DK), Lena-Marie Marti n (Erlangen/DE) Reinhard E. Voll (Freiburg/DE), Beatrice Schuler-Thurner, Gerold Schuler Niels Schaft , Stefanie Hoyer, Jan Dörrie (Erlangen/DE)

75 P�� I • W��, 13 S�� • 13:30–15:30

P480 Identi fi cati on of polysaccharides from Clostridium diffi cile as targets for vaccinati on against anti bioti c-associated diarrhea Erik Wegner, Peter Seeberger, Jochen Matt ner (Erlangen/DE) P481 An improved vaccinati on strategy against infecti ous diseases Dagmar Hildebrand, Camila Metz Zumaran, Klaus Heeg (Heidelberg/DE) P483 Autologous whole tumor cell-based vaccines generated with high hydrostati c pressure bear immunogenic potenti al and act synergisti cally with radiotherapy to retard tumor growth Benjamin Frey, Christoph Seitz, Eva-Maria Weiss, Michael Rückert, Eberhard Schlücker Niels Schaft , Rainer Fietkau, Udo S. Gaipl (Erlangen/DE) P484 Vaccinati on for hepati ti s B in healthy adults, eff ect of sexe and age – two protocols of revaccinati on in nonresponders Jacques Choucair, Zaki Sleiman (Beirut/LB) P485 What do lebanese women know about cervical cancer and human papillomavirus?: a report on awareness levels in urban communiti es Jacques Choucair, Sarah Abboud (Beirut/LB) P486 Elite athletes show more pronounced inducti on of infl uenza-specifi c T cells aft er tetravalent infl uenza vaccinati on than controls Alexandra Ledo, David Schub, Tina Schmidt (Homburg/DE), Clemens Ziller Tanja Stenger (Saarbrücken/DE), Barbara Gärtner (Homburg/DE) Tim Meyer (Saarbrücken/DE), Marti na Sester (Homburg/DE) P487 A Japanese encephaliti s virus vaccine inducing anti bodies strongly enhancing in vitro infecti on is protecti ve in pigs Obdulio García-Nicolás, Meret E Ricklin, Mathias Liniger, Nathalie J. Vielle Sylvie Python (Mitt elhäusern, Bern /CH), Philippe Souque Pierre Charneau (Paris/FR), Artur Summerfi eld (Mitt elhäusern, Bern/CH) P488 Two novel iNKT cell depleti on approaches give insights to the kineti cs of alternati ve cross-priming Christoph Heuser (Bonn/DE), Christi na Courrèges (Bonn/DE; Cambridge/GB) Marie-Sophie Philipp (Bonn/DE), Christoph A. Thaiss (Bonn/DE; Rehovot/IL) Verena Dykstra, César Evaristo (Bonn, Bergisch Gladbach/DE) Christi an Kurts (Bonn/DE; Rehovot/IL) P489 Targeti ng of the C-type lecti n receptor Macrophage galactose-type lecti n (MGL) using MUC1-derived glycopepti des Gerard Arti gas Solé (Sapporo/JP), Joao Monteiro, Bernd Lepenies (Hannover/DE) Fayna García-Marti n (Sapporo/JP)

76 P��DC �� I • W��,2018 13 S�� • 13:30–15:30 15th International Symposium on DENDRITIC CELLS JOINTLY ORGANIZED BY DUTCH AND GERMAN SCIENTISTS

Main topics 1 – DC ontogeny & development 2 – Transcriptional & epigenetic regulation of DC 3 – Antigen processing & presentation 4 – T cell priming & polarization 5 – DC subsets & functional specialization 6 – DC interaction with commensal microbiota 7 – DC in tolerance & tissue homeostasis 8 – DC in allergy & autoimmunity 9 – DC in chronic infections 10 – DC in cancer & cancer immunotherapy 11 – DC vaccination & immunotherapy (beyond cancer) 12 – Omics approaches to dissect DC heterogeneity & networks Abstract submission on www.dc-2018.com

10 14 JUNE 2018 AACHEN • GERMANY OLD IMPERIAL CITY IN THE HEART OF EUROPE 77 P�� II • T��, 14 S�� • 13:30–15:30

B Cells II P44–P66 p. 78 Chronic Inﬂ ammati on & Autoimmunity II P97–P118 p. 80 Complement P119–P132 p. 81 Dendriti c Cells P133–P157 p. 83 Infecti on II P207–P236 p. 85 NK Cells & other Innate Immune Cells II P289–P299 p. 87 Signaling and transcripti onal Regulati on in Immune Cells P321–P346 p. 88 Tumor Immunology & Immunotherapy II P461–P476 p. 90 Veterinary Immunology P490–P506 p. 92

B Cells II P44 IL-10 producing B cells protect against LPS-induced intrauterine fetal death in B cell defi cient mice Mandy Busse, Desiree Nowak, Kersti n Wollschläger, Serban-Dan Costa Ana Claudia Zenclussen (Magdeburg/DE) P45 B cells play an important role in the protecti on against infecti on-induced preterm birth Mandy Busse, Ana Claudia Zenclussen (Magdeburg/DE) P46 High expression of SYK plays a criti cal role in consti tuti ve acti vati on oflow CD21 B cells Baerbel Keller, Ina Stumpf, Valenti na Strohmeier, Susanne Usadel (Freiburg/DE) Els Verhoeyen (Lyon/FR), Hermann Eibel, Klaus Warnatz (Freiburg/DE) P47 Strategies for effi cient FcγR-mediated anti body eff ector functi ons during persistent viral i n f e c ti o n Andreas Wieland, Alice Kamphorst, Jin-Hwan Han, Xiaojin Xu (Atlanta, GA/US) Biswa Choudhury (La Jolla, CA/US), Rafi Ahmed (Atlanta, GA/US) P48 Impact of TLR, IL-1R and TACI receptor signaling in a MyD88 L265P mutati on-driven murine model of diff use large B cell lymphoma O.-Oliver Wolz (Tübingen/DE), Gero Kitt el (Cologne/DE), Yamel Cardona Franziska Herster (Tübingen/DE), Hamid Kashkar, H. Christi an Reinhardt (Cologne/DE) Alexander N.R. Weber (Tübingen/DE) P49 BLIMP-1 induces negati ve selecti on and prevents the development of autoreacti ve B cells Corinna Setz (Ulm/DE), Eva Hug (Ulm, Freiburg/DE), Hend Abdelrasoul Mayas Bilal, Ahmad Khadour (Ulm/DE), Thomas Wossning (Freiburg/DE) Hassan Jumaa (Ulm, Freiburg/DE) P50 Complete block of early B cell diff erenti ati on in mice lacking the endosomal adaptor protein p14 Marcin Lyszkiewicz (Hannover, Munich/DE), Daniel Kotlarz (Munich/DE) Natalia Zietara (Hannover, Munich/DE), Gudrun Brandes (Hannover/DE) Jana Diestelhorst (Munich/DE), Silke Glage (Hannover/DE), Elias Hobeika Michael Reth (Freiburg/DE), Lukas Huber (Innsbruck/AT) Andreas Krueger (Frankfurt, Hannover/DE), Christoph Klein (Munich/DE) P51 Infl uence of Vav1 and Vav3 on B cell development and functi on Sebasti an Kieser, Katja Fiedler, Simon Laban, Patrick J. Schuler (Ulm/DE) Klaus-Dieter Fischer (Magdeburg/DE), Thomas K. Hoff mann, Cornelia Brunner (Ulm/DE) P52 The bHLH transcripti on factor TCFL5 and its isoform CHA modulate c-MYC-dependent cancer B cell proliferati on Inés Sánchez Gómez, Javier Gálan Martí nez, Konstanti no Stamatakis, Núria Gironès Manuel Fresno (Madrid/ES)

78 P�� II • T��, 14 S�� • 13:30–15:30

P53 Membrane IgE regulati on and Toll-like receptor signaling in B cells Eileen Rauch, Andreas Ruhl, Sonja Dehnert, Stefanie Paul, Stefan Bauer Philipp Yu (Marburg/DE) P54 The nanoscale organizati on of the BCR and its proximity to inhibitory receptors and redox regulators Milena Bertolotti , Michael Reth (Freiburg/DE) P55 B and T cell-specifi c immunomodulati on by vitamin A and D in a murine type I allergy model Josephine Scholz, Andreas Hutloff , Guido Heine, Margitt a Worm (Berlin/DE) P56 Grb2 and Grap pave the way for BCR-induced ERK acti vati on in human B cells Kanika Vanshylla, Caren Bartsch, Christoff er Hitzing, Laura Kruempelmann Jürgen Wienands, Niklas Engels (Götti ngen/DE) P57 The role of BAFF on human B cell homeostasis Anne Weiß, Niko Langer, Reinhard Voll, Claudia Bossen (Freiburg/DE) P58 Nanobodies from Lama glama IgH transgenic mice Thomas Eden, Janusz Wesolowski, Stephan Menzel, Lynn Dieckow, Friedrich Haag Irm Hermans-Borgmeyer, Friedrich Koch-Nolte (Hamburg/DE) P59 CD37-specifi c monoclonal anti bodies as a tool to target B cells Philipp Hagemann (Borstel/DE), Jennifer Hundt, Anika Kasprick (Lübeck/DE) Erwin Duitman (Borstel/DE), Friedrich Koch-Nolte, Friedrich Haag (Hamburg/DE) Silvia Bulfone-Paus (Manchester/GB), Heinz Fehrenbach (Borstel, Giessen/DE) Zane Orinska (Borstel/DE) P60 B cell anti gen receptor signaling in maintenance of mature as well as CLL-like B cells Elias hobeika, Hassan Jumaa (Ulm/DE) P61 Analysis of germinal center and suppressive B cell subpopulati ons in a mouse model for head and neck squamous cell carcinoma Matt hias Brand, Jana Krüger, Sandra Jeske, Simon Laban, Patrick J. Schuler Thomas K. Hoff mann, Cornelia Brunner (Ulm/DE) P62 A20 gene dose eff ects in B cell-mediated autoimmunity in mice Carina Steinecke, Yuanyuan Chu, Marc Schmidt-Supprian (Munich/DE) P63 First proof-of-concept of an anti gen-specifi c plasma cell depleti on in vivo Qingyu Cheng, Adriano Taddeo, Andreas Pelz, Laleh Khodadadi Bimba F. Hoyer, Andreas Radbruch, Falk Hiepe (Berlin/DE) P64 Stromal cell contact and APRIL/BCMA signaling synergize to balance expression of pro- and anti -apoptoti c proteins for plasma cell survival S. Schmidt (Berlin/DE), A. Taddeo (Bern/CH), P. Durek, B. Hoyer, F. Hiepe Hyun-Dong Chang, A. Radbruch (Berlin/DE) P65 Deleti on of miR17~92 results in loss of early haematopoieti c stem cells which can be fully rescued by concomitant loss of the pro-apoptoti c BH3-only protein BIM Kersti n Brinkmann, Craig Hyland, Carolyn de Graaf, Warren S. Alexander Andreas Strasser, Marco Herold (Melbourne, Victoria/AU) P66 Haematopoieti c progenitor cell lines with lymphoid potenti al – a tool to study immune celldiff erenti ati on and functi on Constanze Ett ,l Aparna Sheroy, Susanne Kirschnek, Georg Häcker (Freiburg/DE)

79 P�� II • T��, 14 S�� • 13:30–15:30

Chronic Infl ammati on & Autoimmunity II P97 Selecti ve acti vati on of tumor necrosis factor receptor 2 induces anti -infl ammatory responses and alleviates experimental arthriti s Roman Fischer (Philadelphia, PA/US; Stutt gart/DE), Marcel Proske Maëlle Duff ey (Stutt gart/DE), Hubert Stangl, Rainer Straub (Regensburg/DE) John Bethea (Philadelphia, PA/US), Roland Kontermann, Klaus Pfi zenmaier (Stutt gart/DE) P98 Th2 and eosinophil responses ameliorate arthriti s and infl ammatory bone loss Darja Andreev (Erlangen/DE), Zhu Chen (Erlangen/DE; Hefei/CN), Katharina Oeser Branislav Krljanac, Axel Hueber, Arnd Kleyer, Benno Weigmann, David Vöhringer Georg Schett , Aline Bozec (Erlangen/DE) P100 Characterizati on of the phenotype and acti vity of NK cells and neutrophils in Neuromyeliti s Opti ca Maria Eugenia Schroeder Castagno, Silvina Romero Suarez, Felix Schmidt Friedemann Paul, Carmen Infante Duarte (Berlin/DE) P101 Altered IgG glycosylati on patt erns in lupus mouse models Andrea Maul-Pavicic, Sandra Schaff er, David Rieger, Reinhard E. Voll (Freiburg/DE) P102 A miRNA181a/NFAT5 axis links impaired T cell tolerance, inducti on with autoimmune Type 1 diabetes Isabelle Serr, Victoria K. Flynn (Munich/DE), Benno Weigmann (Erlangen/DE) Anett e-Gabriele Ziegler, Carolin Daniel (Munich/DE) P103 The frequency of suppressor CD4+CD39+ T and Th17 cells in the peripheral blood of the pati ents with rheumatoid arthriti s Nino Kikodze, La Pantsulaia, Tinati n Chikovani (Tbilisi/GE) P104 Modifi cati on in disability scores in rheumatoid arthriti s pati ents taking dialyzable leukocyte extract Toni Homberg, Pedro Hernández, Sonia Mayra Pérez-Tapia Maria del Carmen Jiménez-Martí nez (Mexico/MX) P105 Eff ect of ti tanium disks, micro beads and nanoparti cles on the expression of metallothioneins and bactericidal acti vity in human monocyte-derived macrophages Julia Michel, Alexandru Gudima, Vladimir Riabov, Kondaiah Moganti (Mannheim/DE) Nihal Engin Vrana (Strasbourg/FR), Carsten Sti cht, Harald Klüter Julia Kzhyshkowska (Mannheim/DE) P106 Generati on of anti -infl ammatory macrophages for implants and regenerati ve medicine using self-standing release systems with a phenotype-fi xing cytokine cocktail formulati on Vladimir Ryabov (Mannheim/DE; Tomsk/RU), Alexandru Gudima (Mannheim/DE) Nihal Engin Vrana (Strasbourg/FR), Harald Klüter Julia Kzhyshkowska (Mannheim/DE; Tomsk/RU) P107 Hyperglycemic programming of innate immunity – perspecti ves for personilised preventi on of diabeti c cardiovascular complicati ons Michael Balduff , Kondaiah Moganti , Harald Klueter (Mannheim/DE) Marti n Harmsen (Groningen/NL), Julia Kzhyshkowska (Mannheim/DE; Tomsk/RU) P108 Hyperglycemia induces infl ammatory programming of macrophages by acti vati ng histone code at S100A9 and A12 promoters Marije Mossel, Kondaiah Moganti , Harald Klüter (Mannheim/DE) Marti n Harmsen (Groningen/NL), Julia Kzhyshkowska (Mannheim/DE) P109 Fractalkine-mediated monocyte to trophoblast adhesion inducesrelease of infl ammatory factors Jacqueline Serbin (Graz/AT), Julianna Zadora, Andras Balogh (Berlin/DE) Marti n Gauster (Graz/AT), Florian Herse (Berlin/DE) 80 P�� II • T��, 14 S�� • 13:30–15:30

P110 Novel mechanism mediated by the IL23/Th17 axis contributi ng to auto-immune arthriti s Rene Pfeifl e, Tobias Rothe, Natacha Ipseiz, Stephan Culemann, Ulrike Harre Georg Schett , Gerhard Krönke (Erlangen/DE) P111 Deleti on of tumor necrosis factor α receptor 1 leads to increased ti ssue damage and fi brosis in the chronically infl amed liver Laura Berkhout, Birgit Schiller, Gevitha Ravichandran, Till Krech, Gabriele Sass Gisa Tiegs, Roja Barikbin (Hamburg/DE) P112 Molecular characterizati on of magneti cally isolated macropinosomes from primary mouse macrophages defi cient in acid sphingomyelinase Victoria Sohst, Maike Burmeister (Borstel/DE), Ute Distler (Mainz/DE) Christi ne Hess (Jena/DE), Dieter Adam, Stefan Schütze (Kiel/DE) Ulrich E. Schaible (Borstel/DE), Stefan Tenzer (Mainz/DE), Norbert Reiling (Borstel/DE) P113 Nuclear autoanti gen-reacti ve CD4+ T cells are expanded in SLE correlate with disease acti vity, invade target organs such as the kidney, and outnumber their regulatory counterparts Dimas Abdirama, Sebasti an Tesch (Berlin/DE), Caroline von Spee-Mayer (Freiburg/DE) Jens Humrich (Lübeck/DE), Alexander Scheff old, Andreas Radbruch Gerd-Rüdiger Burmester (Berlin/DE), Gabriela Riemekasten (Lübeck/DE) Philipp Enghard (Berlin/DE) P114 Inhibiti on of pepti dyl-arginine deiminases impairs NLRP3 infl ammasome assembly and the release of pro-infl ammatory IL-1b in macrophages Neha Mishra (Greifswald/DE), Fareed Ahmad (Hannover/DE), Lidja Ghebremariam Markus Lerch (Greifswald/DE), Reinhold Ernst Schmidt (Hannover/DE) Lukas Bossaller (Greifswald/DE) P115 Geneti c polymorphism in transforming growth factor beta-1 (TGFB1) in Algerian type 1 Diabetes Esma Mihoubi, Habiba Amroun, Rachida Raache, Sara Belarbi, Nahla Benhalilou Chafi a Touil-Boukoff a, Att al Nabila (Algiers/DZ) P116 Infl ammatory memory in synovial fi broblast mediats chronifi cati on of arthrits Christi ane Reinwald, Benjamin Wirth, Adela Rauschenberg Christi ne Czegley (Erlangen/DE), Andrew Filer, Christopher Buckley (Birmingham/GB) Georg Schett , Markus Hoff mann (Erlangen/DE) P117 Circadian rhythms of immune cells in healthy individuals and pati ents with rheumatoid arthriti s Siska Wilantri, Dimas Abdirama, Cindy Strehl, Robert Biesen, Edgar Wiebe Frank Butt gereit (Berlin/DE) P118 Anti renal CD4+ T cells arise in lupus nephriti s, are mainly of the Th1 phenotype, are only parti ally controlled by their regulatory counterparts and invade the infl amed kidneys Sebasti an Tesch, Dimas Abdirama, Anna-Sophie Griessbach (Berlin/DE) Jens Humrich (Lübeck/DE), Alexander Scheff old, Andreas Radbruch Gerd-Rüdiger Burmester, Kai-Uwe Eckardt, Falk Hiepe (Berlin/DE) Gabriela Riemekasten (Lübeck/DE), Philipp Enghard (Berlin/DE)

Complement P119 Protecti ve and deleterious eﬀ ects of complement serum on zinc-supplemented eti nal pigment epithelial cells Susanne Wasmuth, Marti n Busch, Albrecht Lommatzsch, Kevin Gilhaus (Münster/DE) Arnd Heiligenhaus, Daniel Pauleikhoﬀ (Münster, Essen/DE)

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P120 Kallikrein represents an independent complement acti vator Sarah Irmscher, Nadia Döring, Luke D. Halder, Emeraldo Jo, Ilse D. Jacobsen Peter F. Zipfel, Christi ne Skerka (Jena/DE) P121 The complement system in preeclampsia Bianca Schröder-Heurich, Katja Borns, Constanti n von Kaisenberg (Hannover/DE) Meike Heurich-Sevcenco, B.Paul Morgan (Cardiff /GB) Frauke von Versen-Höynck (Hannover/DE; Stanford, CA/US) P122 Complement C5a ti ps the pH balance in neutrophils Stephanie Denk, Christoph Schmidt, Rebecca Wiegner (Ulm/DE), Jörg Köhl (Lübeck/DE) Markus S. Huber-Lang (Ulm/DE) P123 Experimental food-induced anaphylaxis is driven by C5aR1 actvivati on on mast cells Jörg Köhl (Lübeck/DE; Cincinnati , OH/US), Anna Kordowski (Lübeck/DE), David Wu Simon Hogan (Cincinnati , OH/US) P124 Assessing C5aR2 expression in myeloid and lymphoid cells using a novel fl oxed tdTomato-C5aR2 reporter gene knockin Christi an Karsten, Yves Laumonnier, Anna Wiese, Larissa Almeida Daria Briukhovetska, Anna Kordowski, Katharina Bröker, Jörg Köhl (Lübeck/DE) P125 C5aR2 is expressed in NK cells during acute Toxoplasma gondii infecti on and controls NK cell functi on in vitro Fabian Mey, Daria Briukhovetska, Birte Ohm, Jörg Köhl, Christi an Karsten (Lübeck/DE) P126 C5aR1 is diff erenti ally regulated in innate immune cells during the eff ector phase of allergic asthma Yves Laumonnier, Anna Wiese, Fanny Ender, Christi an Karsten, Jing Sun Inken Schmudde, Peter König, Tillman Vollbrandt (Lübeck/DE) Jörg Köhl (Lübeck/DE; Cincinnati , OH/US) P127 Anaphylatoxin receptor C5aR1 modulates endosomal TLR-triggered type I IFN responses by pDC Yves Laumonnier, Hanna Ulrich, Jing Sun (Lübeck/DE), Patrick Reamer (Munich/DE) Admar Vershoor (Lübeck/DE) P128 Aspf2 from Aspergillus fumigatus disrupts host innate immune response by recruiti ng complement regulators Factor H, FHL-1 CFHR1, and plasminogen Prasad Dasari, Iordana Shopova, Dirk Wartenberg Peter Hortschansky (Jena/DE), Niklas Beyersdorf (Würzburg/DE), Christi ne Skerka Axel A. Brakhage, Peter F. Zipfel (Jena/DE) P129 Radiotherapy modulates anti body-induced complement-mediated tumor cell killing Yingying Liang, Peter Huber, Michael Kirschfi nk (Heidelberg/DE) P130 Acti vati on of the classical pathway by anti -erythrocyte alloanti bodies from diff erent blood groups – ranking of complement acti vati on potency in a homologous test System Markus Anliker, Christoph Schmidt, Inge von Zabern, Georgi Ganchev Britt a Höchsmann, Christof Weinstock, Hubert Schrezenmeier (Ulm/DE) P131 Relevance of anaphylatoxin receptors in experimental infecti on with Mycobacterium tuberculosis Miriam Krusch, Jochen Behrends (Borstel/DE), Jörg Köhl (Lübeck/DE), Christoph Hölscher Kersti n Walter (Borstel/DE) P132 Complement drives neurodegenerati on in Gaucher disease Manoj Pandey, Daniel Magnusen, Mary McKay, Albert Magnusen, Reena Rani Madison Caballero, Wujuan Zhang, Kenneth Setchell Gregory Grabowski (Cincinnati , OH/US), Jörg Köhl (Lübeck/DE; Cincinnati , OH/US)

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Dendriti c Cells P133 Infecti on of mice with community-associated methicillin-resistant Staphylococcus aureus compromises dendriti c cells and increases regulatory T cells via PSM pepti des Nicole S. Armbruster, Jennifer R. Richardson, Juliane Klenk, Manina Günter Stella E. Autenrieth (Tübingen/DE) P134 Elucidati ng the pathophysiological role of dendriti c cells in multi ple myeloma Jennifer R. Richardson, Manina Günter, Katja Weisel, Hans-Jörg Bühring Andreas K. Nüssler, Sabrina Ehnert (Tübingen/DE), Halvard B. Bönig (Frankfurt/DE) Helmut R. Salih, Stella E. Autenrieth (Tübingen/DE) P135 Staphylococcus aureus PSM pepti des modulate human monocyte-derived dendriti c cell functi ons and increase in vitro priming of regulatory T cells Jennifer R. Richardson, Johannes Morschl, Stella E. Autenrieth (Tübingen/DE) P136 Emergency monopoiesis at the expense of dendriti c cell diff erenti ati on upon systemic bacterial infecti ons Kristi n Bieber, Manina Günter (Tübingen/DE), Karina A. Pasquevich (San Martí n/AR) Stella E. Autenrieth (Tübingen/DE) P137 Human lymphoid organ dendriti c cell identi ty is predominantly dictated by ontogeny, not ti ssue microenvironment Gordon Heidkamp (Erlangen/DE), Jil Sander (Bonn/DE), Christi an Lehmann, Lukas Heger Nathalie Eissing, Anna Baranska, Jennifer Lühr, Alana Hoff mann, Katharina Reimer Anja Lux, Stephan Söder, Arndt Hartmann (Erlangen/DE), Johannes Zenk (Augsburg/DE) Thomas Ulas (Bonn/DE), Naomi McGovern (Singapore/SG), Christoph Alexiou Bernd Spriewald, Andreas Mackensen, Gerold Schuler (Erlangen/DE), Burkhard Schauf Anja Forster (Bamberg/DE), Roland Repp (Kiel/DE), Peter Fasching, Ariawan Purbojo Robert Cesnjevar (Erlangen/DE), Evelyn Ullrich (Frankfurt/DE) Florent Ginhoux (Singapore/SG), Andreas Schlitzer (Bonn/DE; Singapore/SG) Falk Nimmerjahn (Erlangen/DE), Joachim Schultze (Bonn/DE), Diana Dudziak (Erlangen/DE) P138 The CD83 molecule – a target for the aryl hydrocarbon receptor in human dendriti c cells Julia Michalski, Lena Sandrock, Andrea Deinzer, Marcello F. Stein, Vera E. Assmann Elisabeth Zinser, Alexander Steinkasserer, Ilka Knippertz (Erlangen/DE) P139 Diff erenti al expression and subcellular localizati on of a novel isoform of Dlg2 in IFNβ producing plasmacytoid dendriti c cells Shafaqat Ali (Düsseldorf, Münster/DE), Alexander Hoven, Regine J. Dress (Düsseldorf/DE), Judith Alferink (Münster/DE), Stefanie Scheu (Düsseldorf/DE) P140 Characterizati on of consti tuti vely DC-defi cient mice in anti viral and autoimmune responses Cornelia Hilpert, Selina Sitt e, David Vöhringer (Erlangen/DE) P141 Gene expression profi les of human resident lamina propria dendriti c cells predict a functi onal role in ti ssue repair and angiogenesis under infl ammatory conditi ons Stefan Kurzhals (Heidelberg/DE), Serin Schiessling (Oldenburg/DE), Thomas Giese Antje Heidtmann, Felix Lasitschka, Mohammed AlSaeedi, Marti n Schneider Stefan Meuer, Jutt a Schröder-Braunstein (Heidelberg/DE) P142 The fungal quorum sensing molecule Farnesol modulates CD1 molecules expression in dendriti c cells Wolfgang Vivas, Ines Leonhardt (Jena/DE), Oliver Kurzai (Jena, Würzburg/DE) P143 Traffi cking of yolk sac macrophage progenitors to the embryo during defi ned stages of development Christi an Schulz, Christopher Stremmel, Ronja Schuchert, Franziska Wagner Robert Pick (Munich/DE), Elvira Mass, Frederic Geissmann (New York, NY/US) Markus Sperandio (Munich/DE) 83 P�� II • T��, 14 S�� • 13:30–15:30

P144 Dendriti c cell-specifi c OTUB1 is required for the control of intracellular parasiti c infecti on Floriana Mulas, Xu Wang, Shanshan Song (Magdeburg/DE) Marti na Deckert (Cologne/DE), Michael Naumann, Dirk Schlüter (Magdeburg/DE) P145 Dissecti ng the T cell-extrinsic requirements for Tfh cell diff erenti ati on Johanna Huber, Dirk Baumjohann (Planegg-Marti nsried/DE) P146 The impact of hepatocyte growth factor receptor/Met tyrosine kinase for dendriti c cell migrati on in skin immunity Zsofi a Sage, Jea-Hyun Baek (Aachen/DE), Carmen Birchmeier (Berlin/DE), Marti n Zenke Thomas Hieronymus (Aachen/DE) P147 Kineti cs and ti ming of IL-12 producti on by dendriti c cells for Th1 priming in vivo DiyaaElDin Ashour, Manfred Lutz (Würzburg/DE) P148 A systems biology approach to characterize the functi on of miRNAs in dendriti c cell-mediated immunogenicity and therapeuti c cancer vaccinati on Xin Lai, Florian Dreyer, Tanushree Jaitly, Kersti n F. Gerer, Gerold Schuler, Jan Dörrie Niels Schaft , Julio Vera (Erlangen/DE) P149 Regulati on of CD73 expression in skin migrati ng dendriti c cells modulates tolerance inducti on in a murine contact hypersensiti vity model Cinthia Silva-Vilches, Alexander Enk, Karsten Mahnke (Heidelberg/DE) P150 Recruitment of dendriti c cell progenitors to peripheral ti ssues Johanna Salvermoser (Planegg-Marti nsried/DE) Andrea Musumeci (Munich, Planegg-Marti nsried /DE), Stephan Rambichler Claudia Schmalhofer, Nikolaos Papaioannou (Planegg-Marti nsried/DE) Anne Krug (Munich, Planegg-Marti nsried /DE) Barbara U. Schraml (Planegg-Marti nsried/DE) P151 Mapping of the human dendriti c cell space in the blood by single-cell mRNA sequencing Peter See, Charles-Antoine Dutertre, Jinmiao Chen (Singapore/SG) Patrick Günther (Bonn/DE), Naomi McGovern, Sergio Erdal Irac (Singapore/SG) Merry Gunawan (Newcastle/GB), Marc Beyer, Kristi an Händler (Bonn/DE) Kaibo Duan, Hermi Rizal Bin Sumatoh (Singapore/SG), Nicolas Ruffi n, Mabel Jouve Ester Gea-Mallorquí (Paris/FR), Raoul C. M. Hennekam (Amsterdam/NL) Tony Lim, Chan Chung Yip, Ming Wen, Benoit Malleret, Ivy Low Nurhidaya Binte Shadan, Charlene Foong Shu Fen, Alicia Tay, Josephine Lum Francesca Zolezzi, Anis Larbi, Michael Poidinger, Jerry K.Y. Chan, Qingfeng Chen Laurent Renia (Singapore/SG), Muzlifah Haniff a (Newcastle/GB) Philippe Benaroch (Paris/FR), Andreas Schlitzer (Bonn/DE; Singapore/SG) Joachim L Schultze (Bonn/DE),Evan W. Newell, Florent Ginhoux (Singapore/SG) P152 Engulfment and acti ve shutt ling of mast cell granules by dendriti c cells – a novel way of immune regulati on Jan Dudeck, Johanna Kotrba, Julia Fröbel, Anne Dudeck (Magdeburg/DE) P153 Myeloid and plasmacytoid dendriti c cell subsets are diff erenti ally regulated by the pregnancy hormone human chorionic Gonadotropin Stefanie Ehrentraut, Karoline Sauss, Ana Claudia Zenclussen Anne Schumacher (Magdeburg/DE) P154 Immune complexes induce recruitment of proinfl ammatory slanDC in human lupus n e p h r i ti s Florina Olaru (Heidelberg/DE), Thomas Döbel (Bethesda, MD/US; Heidelberg/DE) Anke Lonsdorf, Stephanie Oehrl, Alexander Enk, Elisabeth Gröne Hermann-Josef Gröne, Knut Schäkel (Heidelberg/DE) 84 P�� II • T��, 14 S�� • 13:30–15:30

P156 Time and space in leukocyte migrati on Thomas Quast, Donald Guu, Luis Alvarez, Benjamin Kaupp , Waldemar Kolanus (Bonn/DE) P157 Comprehensive characterizati on of human liver-resident monocytes, macrophages and dendriti c cells Glòria Martrus Zapater, Hanna Goebels, Annika Langeneckert, Wilhelm Salzberger Laura Richert, Marti na Koch, Nashan Björn, Sebasti an Lunemann Marcus Altf eld (Hamburg/DE)

Infecti on II P207 Local ti ssue perfusion aff ects the outcome of cutaneous Leishmania major infecti on in diff erent mouse strains Valenti n Schatz, Yannic Struessmann, Jens Wild, Uwe Ritt er Jonathan Jantsch (Regensburg/DE) P208 Interleukin-3 protects against secondary viral infecti ons in sepsis Alan Bénard, Maria Nothing (Erlangen/DE), Florian Uhle Thorsten Brenner (Heidelberg/DE), Kenia Ubieta, Isabella Kutschick, Maximilian Brunner Angelika Albert, Maximilian Kalb, Katharina Maier, Paul Ött l, Anastasia Gasplmayr Christi an Pilarsky (Erlangen/DE), Markus A. Weigand (Heidelberg/DE) Filip K. Swirski (Boston, MA/US), Robert Grützmann, Georg F. Weber (Erlangen/DE) P209 Acid sphingomyelinase inhibiti on suppresses mycobacteria-mediated release of nitric oxide producti on and infl ammatory cytokines in myeloid-derived suppressor cells Vini John, Sibylle Schneider-Schaulies (Würzburg/DE), Erich Gulbins (Essen/DE) Manfred Lutz (Würzburg/DE) P210 Role of acid sphingomyelinase in experimental infl ammatory bowel disease Jana Meiners (Essen/DE), Lukasz Japtok (Nuthetal/DE), Julia Zöller, Wiebke Hansen Astrid Westendorf (Essen/DE) P211 Anti viral immunity, galecti ns and the interacti on of hantavirus with professional anti gen presenti ng cells Marti n Raft ery, Friderika Weege, Alexander Karlas, Thomas Meyer, Detlef Kruger Boris Klempa, Günther Schönrich (Berlin/DE) P212 The eff ect of calcium (Ca2+) concentrati on on the internalizati on process of Staphylococcus aureus by kerati nocytes Dennis Nurjadi, Larissa Faaß, Aline Sähr, Klaus Heeg (Heidelberg/DE) P213 Interplay of bacteria- and host-derived anti microbial pepti des in pathogen clearance on the skin Laura Klink, Hanna Dehmer, Katharina Bitschar, Birgit Schitt ek (Tübingen/DE) P214 Deciphering the role of eosinophils in a mouse model of allergic bronchopulmonary aspergillosis (ABPA) Axel Dietschmann (Erlangen/DE), Ralf Willebrand (Erlangen/DE; Hasselt/BE) Sebasti an Schruefer, Sven Krappmann, David Vöhringer (Erlangen/DE) P215 Resoluti on and chronicity of Q-fever in the mouse model – Myd88-defi ciency and overexpression of IL-10 impairs clearance of Coxiella burneti i nine mile phase II Lisa Kohl, Anja Lührmann, Roland Lang (Erlangen/DE) P216 Long-term persistence of Leishmania major even in the absence of host cell arginase 1 Katrin Paduch, Andrea Debus, Ulrike Schleicher, Christi an Bogdan (Erlangen/DE)

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P217 Criti cal nodes of viral modulati on revealed through an integrated network analysis of host-virus interacti on landscape Korbinian Bösl (Trondheim/NO), Jacques Colinge (Montpellier/FR; Vienna/AT) Giulio Superti -Furga (Vienna/AT), Berend Snijder (Zurich/CH) Richard K. Kandasamy (Trondheim/NO) P218 Adenoviral infecti on with hepatocyte-restricted anti gen expression leads to persistent i n f e c ti o n Katrin Manske, Nina Bötti nger, Miriam Bosch, Katja Steiger, Percy A. Knolle Dirk Wohlleber (Munich/DE) P219 Eff ect of iron on the immune response in L.major-infected mice Stephanie Obermeyer, Ulrike Schleicher, Christi an Bogdan (Erlangen, Nürnberg/DE) P220 Mechanisms of TNF-Mediated Control of Leishmania major Johanna Schäfer, Andrea Debus, Katrin Paduch, Ulrike Schleicher Christi an Bogdan (Erlangen/DE) P221 Expansion and regulati on of type II innate lymphoid cells during infecti on with the gastrointesti nal helminth Strongyloides ratti Marti na Reitz, Marie-Luise Brunn, Minka Breloer (Hamburg/DE) P222 Non-canonical autophagy as a mechanism to secure Leishmania survival in human host macrophages? Rebecca Bohn, Anne-Kathrin Knuth, Peter Crauwels, Stefan Schille (Langen/DE) Ger van Zandbergen (Langen, Mainz/DE) P223 Cathelicidin does the job – killing Leishmania in human primary macrophages Peter Crauwels, Elena Bank, Bianca Walber (Langen/DE) Ulf Alexander Wenzel (Gothenburg/SE), Markos Abebe Menberework Chanyalew (Addis Ababa/ET), Renate König (Langen/DE) Uwe Ritt er (Regensburg/DE), Norbert Reiling (Borstel/DE) Ger van Zandbergen (Langen, Mainz/DE) P224 A family of anti microbial proteins acti vates virulence of Salmonella enterica Roman Gerlach (Wernigerode/DE), Irene Witt mann, Olaf Pinkenburg, Torben Meyer Sven-Andreas Freibert (Marburg/DE), Christi ane Schmidt (Wernigerode/DE) Michael Hensel (Osnabrück/DE), Manfred Rohde (Braunschweig/DE) Markus Schnare (Marburg/DE) P226 The infl uence of postnatal infecti ous challenge on enteric ti ssue maturati on Stefan Schlößer, Nastaran Fazel Modares, Kaiyi Zhang (Aachen/DE) Urska Repnik (Oslo/NO), Aline Dupont, Mathias Hornef (Aachen/DE) P227 The C-type lecti n receptor Mincle recognises Group A Streptococcus (GAS) and impacts cytokine producti on in vitro but plays a limited role during GAS infecti on in vivo Sabine Mayer (Hannover/DE), Sho Yamasaki (Fukuoka/JP) Nina M van Sorge (Utrecht/NL), Bernd Lepenies (Hannover/DE) P228 Helminth-induced immunomodulati on enhances rather than suppresses anti -viral immunity via IFN-γ and Granzyme B in a dynamic patt ern Eva Loff redo-Verde, Sonakshi Bhatt acharjee, Antje Malo (Munich/DE) Mathias Heikenwälder (Munich, Heidelberg/DE), Ulrike Protzer Clarissa Prazeres da Costa (Munich/DE)

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P229 Aberrant plasma IL-7 and soluble IL-7 receptor-α levels indicate impaired T-cell response to IL-7 in human tuberculosis Christi an Lundtoft (Düsseldorf/DE), Anthony Afum-Adjei Awuah (Kumasi/GH) Jens Rimpler, Kirsti n Harling, Norman Nausch, Malte Kohns, Franziska Lang Ertan Mayatepek (Düsseldorf/DE), Ellis Owusu-Dabo (Kumasi/GH) Marc Jacobsen (Düsseldorf/DE) P230 Characterizati on of the protein tyrosine phosphatase LmPRL-1 secreted by Leishmania major via the exosome pathway Sabine Leitherer (Erlangen/DE), Joachim Clos (Jena/DE) Elisabeth M. Liebler-Tenorio (Hamburg/DE), Ulrike Schleicher, Christi an Bogdan Didier Soulat (Erlangen/DE) P231 The role of neutrophils during chlamydia infecti on Tom Zortel, Juliane Vier, Georg Häcker, Susanne Kirschnek (Freiburg/DE) P232 Absence of B cells results in a defecti ve CD8+T cell response in Trypanosoma cruzi i n f e c ti o n Facundo Fiocca Vernengo, Cristi an Gabriel Beccaría, Jimena Tosello Boari Cinti a Araujo Furlán, Melisa Gorosito Serrán, Carolina Lucía Montes Eva Virginia Acosta Rodriguez, Adriana Gruppi (Córdoba/AR) P233 Role of Th2/1 hybrid cells in parasite infecti ons Sebasti an Rausch, Nicole Affi nass, Cristi n Bock (Berlin/DE), Susbash Babu (Chennai/IN) Susanne Hartmann (Berlin/DE) P234 Dynamics and traffi cking of mGBP protein complexes within membranous compartments Nora Steff ens, Larissa Legewie, Elisabeth Kravets, Daniel Degrandi Klaus Pfeff er (Düsseldorf/DE) P235 Interacti on of indoleamine 2,3-dioxygenase and inducible nitric oxide synthase regulate anti microbial growth control in human reti nal pigment epithelium cells in vitro Christoph-Marti n Ufermann, Maike Oldenburg, Walter Däubener (Düsseldorf/DE) P236 Acti vati on of neutrophils by Chlamydia trachomati s-infected epithelial cells is modulated by the chlamydial plasmid Saskia Lehr, Svenja Barth, Juliane Vier, Georg Häcker, Susanne Kirschnek (Freiburg/DE)

NK Cells & other Innate Immune Cells II P289 A criti cal role for AhR-signaling in keeping an anti -infl ammatory state of dendriti c epidermal T cells? Katja Merches, Charlott e Esser (Düsseldorf/DE) P290 Mast cell-derived TNF targets circulati ng neutrophils to license the diapedesis to infl amed ti ssue Jan Dudeck (Magdeburg/DE), Roland Immler (Munich/DE) Sergei A. Nedospasov (Berlin/DE), Markus Sperandio (Munich/DE) Anne Dudeck (Magdeburg/DE) P291 Organ specifi c involvement of ti ssue-resident macrophages as eff ector cells of cytotoxic anti bodies Sina Gordan, Markus Biburger, Falk Nimmerjahn (Erlangen/DE) P292 Regulati on of arthriti s by type 2 innate lymphoid cells Yasunori Omata, Sébasti en Lucas, Stefan Wirtz, Aline Bozec, Georg Schett Mario Zaiss (Erlangen/DE)

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P293 KIR3DS1/HLA-F interacti ons in Hepati ti s C virus infecti on Sebasti an Lunemann, Anja Schöbel, Janine Kah, Angelique Hölzemer (Hamburg/DE) Wilfredo Garcia Beltran (Cambridge, MA/US), Maura Dandri, Eva Herker Marcus Altf eld (Hamburg/DE) P294 Spati o-temporal granzyme B and caspase-8 acti vity in tumor cells during serial killing by natural killer cells Clarissa Liesche (Heidelberg/DE), Doris Urlaub, Isabel Prager (Dortmund/DE) Patricia Sauer (Heidelberg/DE), Maren Claus (Dortmund/DE), Roland Eils Joel Beaudouin (Heidelberg/DE), Carsten Watzl (Dortmund/DE) P295 Direct and anti body-dependent NK cell-mediated tumor killing is suppressed by MUC1 in vitro Thais Langer Jacobus, Frederike Nordmeier, Reinhold Schmidt Roland Jacobs (Hannover/DE) P296 Innate guardians – ti ssue-resident NK cells in the infant small intesti ne Adrian Sagebiel, Sebasti an Lunemann, Christi an Körner (Hamburg/DE) Renee Schreurs (Amsterdam/NL), Marcus Altf eld, Daniel Perez Konrad Reinshagen (Hamburg/DE), Madeleine J Bunders (Hamburg/DE; Amsterdam/NL) P297 The transcripti on factor PLZF is associated with the expression of ti ssue-homing receptors on blood-derived human CD56bright NK cells Leonard Hess, Sebasti an Lunemann, Glòria Martrus, Annika Langeneckert Wilhelm Salzberger, Tobias Poch, Hanna Goebels (Hamburg/DE) Madeleine Bunders (Hamburg/DE; Amsterdam/NL), Marti na Koch Christoph Schramm, Karl J. Oldhafer, Björn Nashan, Marcus Altf eld (Hamburg/DE) P298 IL-4Rα-dependent macrophage responses in the liver during murine schistosomiasis Marion Rolot, Annett e Dougall, Laurent Gillet (Liège/BE) Frank Brombacher (Cape Town/ZA), Alain Vanderplasschen, Benjamin Dewals (Liège/BE) P299 Glioblastoma target cell interacti ons with cytokine-acti vated lymphocytes guided by cytotoxicity and micropinocytosis Yizhou Zhuo (Nanjing/CN), Marion Schneider, Haouraa Mostafa (Ulm/DE)

Signaling and Transcripti onal Regulati on in Immune Cells P321 Virtual immune cells – a central repository of biochemical networks for the visualizati on and analysis of high-throughput data in immunology Marti n Eberhardt, Philipp Junk, Pia Wentker, Florian Dreyer (Erlangen/DE) Wilhelm Bertrams, Bernd Schmeck (Marburg/DE), Julio Vera (Erlangen/DE) P322 S100 alarmin-induced innate immune programming protects newborn infants from sepsis Thomas Ulas (Bonn/DE), Sabine Pirr (Hannover/DE), Joachim Schultze (Bonn/DE) Dorothee Viemann (Hannover/DE) P323 DNA Methylati on involved in IFNγ regulati on of IL-18BP Expression Malte Bachmann, Josef Pfeilschift er, Heiko Mühl (Frankfurt/DE) P324 Nrf2 enhances metabolic turnover in myeloid cells resulti ng in enhancement of CD11b+Gr-1+ MDSCs Kim Ohl, Patricia Klemm, Athanassios Fragoulis, Julian Baumeister, Wiebke Kloc Eva Verjans, Svenja Böll, Julia Möllmann, Michael Lehrke, Bernd Denecke Angela Schippers, Norbert Wagner, Christoph Wruck, Klaus Tenbrock (Aachen/DE)

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P325 Lysine 709 plays a pivotal role in STAT3 functi on Benedikt Spielberger, Beti na Obermair (Munich, Heuherberg/DE) Simon Pelham (Darlinghurst/AU), Andreas Schlundt (Garching, Neuherberg/DE) Dharmendra Pandey (Munich/DE), Michael Satt ler (Garching, Neuherberg/DE) Stuart Tangye (Darlinghurst/AU), Simon Rothenfusser Ellen Renner (Munich, Heuherberg, Augsburg/DE; Davos/CH) Beate Hagl (Munich, Heuherberg, Augsburg/DE) P326 Inhibited Arginase-1 expression by Fra-1 in myeloid cells enhance rheumatoid arthriti s inﬂ ammati on Nicole Hannemann, Anne Schnelzer, Jutt a Jordan, Marti n Eberhardt Ulrike Schleicher, Steﬀ en Uebe, Arif Ekici, Stephen Reid, Sophia Sonnewald Tobias Bäuerle, Christi an Bogdan, Julio Vera, Georg Schett , Aline Bozec (Erlangen/DE) P327 Rab8 coordinates the secreti on of IL-8 upon TLR5 sti mulati on under physiological oxygen concentrati on in colon epithelial cells Sabrina Klein, Sandra Förmer, Aline Sähr, Klaus Heeg (Heidelberg/DE)

P328 In vivo dynamics of IκBNS promotor acti vity in innate and adapti ve immune cell subsets during Listeria monocytogenes infecti on in mice Alexander Pausder (Magdeburg/DE), Dunja Bruder Ingo Schmitz (Munich, Heuherberg, Augsburg/DE), Andreas Jeron Sarah Frentzel (Magdeburg/DE) P329 Transcripti onal dysregulati on of CVID pati ents harboring C104R TNFRSF13B mutati on Neft ali Ramirez, Bodo Grimbacher, Claudia Bossen (Freiburg/DE) P330 TRAF1 does not compensate for TRAF2 defi ciency in tumor necrosis factor (TNF) receptor superfamily (TNFRSF) signaling Jennifer Kreckel, Daniela Siegmund, Harald Wajant (Würzburg/DE) P331 Receptor- and pathway-specifi c functi ons of the death domainproteins TRADD, RIP and FADD Simone Füllsack, Alevti na Rosenthal, Harald Wajant, Daniela Siegmund (Würzburg/DE) P332 The phosphoproteome of cord factor-acti vated primary macrophages Madlen Hansen (Erlangen/DE), Julien Pelti er, Matt hias Trost (Dundee/GB) Roland Lang (Erlangen/DE) P333 FcRγ is a central adaptor subunit for immune receptors on myeloid cells Jenny Ostrop, Christi na Kerntke, Håvard Gullik Sørbø (Trondheim/NO) Roland Lang (Trondheim/NO; Erlangen/DE), Menno Oudhoff (Trondheim/NO) P334 Cross-regulati on of DNA-damage response and TLR signaling in macrophages Faizal Ali Mohamed Raffi , Roland Lang (Erlangen/DE) P335 A hierarchical and ti me-dependent model of transcripti on factor regulati on following macrophage acti vati on Kevin Baßler, Joachim L. Schultze, Anna C. Aschenbrenner (Bonn/DE) P336 MicroRNA-31 modulates the expression of mobility related genes and the mobility of repeatedly acti vated T helper 1 lymphocytes Markus Bardua, Claudia Haft mann, Pawel Durek, Kersti n Westendorf, Antje Butt gereit Mairi Mcgrath, Cam Loan Tran, Melanie Weber, Katrin Lehmann, Gitt a Anne Heinz Anna-Barbara Sti tt rich, Patrick Mashmeyer, Helena Radbruch, Nikolaus Rajewsky Hyun-Dong Chang, Andreas Radbruch, Mir-Farzin Mashreghi (Berlin/DE) P337 LPS-induced metabolic processes in human polarized macrophages Ronald Weiß, Erik Schilling, Anja Grahnert, Ulrich Sack, Sunna Hauschildt (Leipzig/DE)

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P338 The Neurobeachin-like 2 protein (NBeal2) regulates mast cell homeostasis Sebasti an Drube, Randy Grimlowski (Jena/DE), Carsten Deppermann (Würzburg/DE) Anne Dudeck (Magdeburg/DE), Nico Andreas (Jena/DE), David Stegner Bernhard Nieswandt (Würzburg/DE), Thomas Kamradt (Jena/DE) P339 The cytokine response in FAT10-defi cient mice Mei Min Mah, Michael Basler, Marcus Groett rup (Konstanz/DE) P340 Transcripti onal regulati on of the human C-type lecti n-like receptor NKp65 Ines Kühnel, Björn Bauer, Stefan Leibelt, Alexander Steinle (Frankfurt/DE) P341 The paradox of IL-1β secreti on and anti -infl ammatory programming by short-chain fatt y acids in human macrophages Susanne Schmidt, Bianca Marti n, Wei Wang, Philippa Meiser, Fabian Fischer Mario Lauterbach, Liv Ryan, Terje Espevik, Joachim Schultze, Eicke Latz (Bonn/DE) P342 Characterizati on of Cytokine-Inducible SH2 protein (CISH) eff ectson CD4+ T cell phenotype and functi on Alptekin Güler, Julia Seyfarth, Norman Nausch, Ertan Mayatepek Marc Jacobsen (Düsseldorf/DE) P343 Involvement of TRIF in macrophage response to TLR2 ligands Sara Francisco (Madrid/ES), Estefanía Rodríguez-García Gloria Gonzalez-Aseguinolaza (Pamplona/ES), Manuel Fresno, Alicia Arranz (Madrid/ES) P344 Extracellular matrix-dependent role of cytohesin-2 in podosome formati on and functi on in myeloid cells Angrit Namislo, Waldemar Kolanus (Bonn/DE) P345 Cytohesin-3 is required for full insulin receptor acti vati on and changes the metabolic phenotype of mice during aging Betti na Jux, Felix Tolksdorf, Christa Mandel, Waldemar Kolanus (Bonn/DE) P346 Direct visualizati on of cell surface ATP release and cytosolic ATP depleti on following acti vati on of the P2X7 receptor using FRET-based sensors Klaus Eric Kaschubowski, Bjarne Johnsen, Enja Schneider, Friedrich Koch-Nolte Friedrich Haag (Hamburg/DE)

Tumor Immunology & Immunotherapy II P461 Paclitaxel synergizes with exposure ti me adjusted CD22-targeted immunotoxins against B-cell malignancies Fabian Müller (Erlangen/DE; Bethesda, MD/US), Stephanie Stookey, Tyler Cunningham Xiu-Fen Liu (Bethesda, MD/US), Alan S. Wayne (Los Angeles, CA/US) Ira Pastan (Bethesda, MD/US) P462 Expression of multi ple transcript variants of the heavy chain of neonatal Fc receptor FCGRT in Ewing sarcoma cells Thekla Wünsche, Benny Yau, Ines Volkmer, Alexander Emmer Marti n Staege (Halle/DE) P463 The role of calcitriol and its analogs in CCL2- and osteoponti n-mediated crosstalk between immune host and cancer cells in mouse mammary gland cancer model Artur Anisiewicz, Agata Pawlik, Beata Filip-Psurska, Joanna Wietrzyk (Wrocław/PL) P464 Impact of calcitriol and its analogs on balance between Treg and Th17 cells proﬁ le in mouse mammary gland tumor model Agata Pawlik, Artur Anisiewicz, Beata Filip-Psurska, Joanna Wietrzyk (Wrocław/PL)

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P465 Autophagy in human primary macrophages is independent of ULK-1 and Beclin-1 Rebecca Bohn, Peter Crauwels, Pascal Devant, Tim Haselwander (Langen/DE) Jan W. Drijfh out (Leiden/NL), Stefan Tenzer (Mainz/DE) Ger van Zandbergen (Langen, Mainz/DE) P466 In vivo generati on of functi onal anti gen-reacti ve T cell receptor-engineered T cells Uckert Wolfgang (Berlin/GB) P467 Micro-RNAs regulati ng the expression of HLA class I anti gen processing components in melanoma Maria Filothei Lazaridou, Jürgen Bukur, Diana Handke, Anja Mueller, Sandy Tretbar Michael Friedrich, Stefan Huett elmaier (Halle/DE), Stefanie Meyer (Regensburg/DE) Barbara Seliger (Halle/DE) P468 Infl ammatory status of apparently healthy elderly and colorectal cancer pati ents Ia Pantsulaia, Archil Aladashvili, Nino Kikodze, Manana Iobadze, Tsitsino Atamashvili Tinati n Chikovani (Tbilisi/GE) P469 YKL-39 induces monocytes migrati on and angiogenesis and inversely correlates with metastasis in pati ents with breast cancer Julia Kzhyshkowska (Mannheim/DE; Tomsk/RU), Irina Mitrofanova (Tomsk/RU) Tengfei Liu (Mannheim/DE), Marina Zavyalova, Nikolai Litvyakov Mikhail Buldakov (Tomsk/RU), Harald Klueter (Mannheim/DE) Nadezhda Cherdyntseva (Tomsk/RU) P470 Anti gen-specifi c T cell redirectors (ATR) – an anti gen-specifi c approach to kill tumors Simone Bernardino-Pott hast (Langen/DE), Armin Gerbitz (Berlin/DE) Karlo Perica (Balti more, MD/US), Juan C. Varela (Charleston, SC/US) Carl Haupt, Mathias Oelke, Jonathan P. Schneck (Balti more, MD/US) Christi an Schütz (Langen/DE) P471 The role of Galecti n-1 as a immune regulator in a novel orthotopic NB mouse model Christi ne Weißenborn, Irina Lenko (Magdeburg/DE), Leonid S. Metelitsa (Houston, TX/US) Ana Claudia Zenclussen, Stefan Fest (Magdeburg/DE) P472 All trans reti noic acid modulates TLR4 and TLR9 signaling pathway targeti ng cytokines and nitric oxide synthase 2 expression in colonic mucosa during colorectal cancer Hayet Rafa, Sarra Benkhelifa (Lille/FR; Algiers/DZ), Chafi a Touil-Boukoff a (Algiers/DZ) Nadira Delhem (Lille/FR) P473 Galecti n-1 modulates CD8+ T cell response towards tolerance and can be targeted by DNA vaccine to suppress tumor growth in murine neuroblastoma Laura Liebscher (Leipzig/DE), Elisa Berger (Magdeburg/DE), Robert Preissner (Berlin/DE) Gabriel A. Rabinovich (Buenos Aires/AR), Christi ne Weißenborn (Magdeburg/DE) Nina M. Christi ansen, Holger Christi ansen (Leipzig/DE), Ana C. Zenclussen Stefan Fest (Magdeburg/DE) P474 The (k), but not the (a) splice variant of the ATP-gated P2X7 cati on channel synergisti cally potenti ates the cytotoxic eff ect of doxorubicin in vitro Sana Javed, Janne Becher, Vera Labitzky, Friedrich Koch-Nolte Friedrich Haag (Hamburg/DE) P475 Evaluati on of in vitro acti vity of TRANSFERON™, a pepti de mixture with immunomodulatory properti es in THP-1 macrophages Hugo Valencia, Gabriela Mellado, Gregorio Carballo, Luis Vallejo, Emilio Medina Rommel Chacón, Lenin Pavón, Mayra Pérez (Mexico/MX)

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P476 Metabolic disorders as risk factors of pancreati c cancer – impact of glucose on the diﬀ erenti ati on of macrophages and their interplay with pancreati c ductal epithelial cells Dorothea Plundrich, Philippe Dänzer-Barbosa, Sascha Rahn, Daniela Wesch Susanne Sebens, Ole Helm (Kiel/DE)

Veterinary Immunology P490 Characterizati on of chicken TNFalpha, a long missed cytokine in birds Franziska Rohde (Munich/DE), Benjamin Schusser (Freising/DE) Bernd Kaspers (Munich/DE), Jiri Hejnar, Helena Farkasova, Tomas Hron Daniel Elleder (Prague/CZ) P491 Pentraxin 3 is strongly induced in the course of inﬂ ammatory conditi ons in chickens Nina Burkhardt, Anke Staudt, Susanne Röll, Sonja Härtle (Munich/DE) Daniel Elleder (Prague/CZ), Benjamin Schusser (Freising/DE), Bernd Kaspers (Munich/DE) P492 Characterizati on of host-pathogen interacti ons in an avian whole blood model Sravya Sreekantapuram, Angela Berndt, Christi an Berens, Stefanie Barth Ilse Jacobsen (Jena/DE) P493 Expression dynamics of cytokine mRNAs in the porcine peripheral blood mononuclear cells induced by Trichinella spiralis anti gen tyvelose Sharmin Aqter Rony, Md. Aminul Islam (Bonn/DE; Mymensingh/BD) Maren Julia Pröll, Christi ne Große-Brinkhaus, Dawit Tesfaye, Ernst Tholen Michael Hoelker, Karl Schellander, Christi ane Neuhoﬀ (Bonn/DE) P494 Bovine peripheral blood mononuclear cells are more sensiti ve todeoxynivalenol than those derived from poultry and swine Elisabeth Mayer, Barbara Novak (Tulln/AT), Eleni Vatzia, Alix Pierron Wilhelm Gerner (Vienna/AT), Gerd Schatzmayr (Tulln/AT) P495 Development of a RACE-based RNA-Seq approach to characterize the T-cell receptor repertoire of porcine γδ T cells Sabine Hammer, Melanie Leopold, Lisa-Maria Prawits, Angela Schlerka Marlies Dolezal, Lukas Endler, Wilhelm Gerner, Armin Saalmüller (Vienna/AT) P496 Changes in phenotype and proliferati on of porcine B cells induced by the mycotoxin deoxynivalenol (DON) Pierron Alix, Vatzia Eleni, Saalmüller Armin (Vienna/AT), Mayer Elisabeth (Tulln/AT) Gerner Wilhelm (Vienna /AT)

P497 Comparison between K3EDTA and Lithium heparin as anti coagulant to isolate granulocytes from bovine blood Shima Baien, Melissa N. Langer, Nicole de Buhr Maren von Köckritz-Blickwede (Hannover/DE) P498 Phenotype and cytokine producti on of porcine gut mucosa-derived T cells Selma Schmidt, Alix Pierron, Eleni Vatzia, Andrea Ladinig, Armin Saalmüller Wilhelm Gerner (Vienna/AT) P499 Microbial colonisati on is essenti al for immune system development in chickens Bernd Kaspers, Sarah Lett mann, Sonja Härtle (Munich/DE) Benjamin Schusser (Freising/DE), Catherine Schouler, Philippe Velge (Nouzilly/FR) P500 Phenotypic and transcriptomic characterizati on of a novel porcine blood dendriti c cell populati on expressing DC precursor-associated genes Gaël Auray (Mitt elhäusern, Bern/CH), Irene Keller (Bern/CH), Sylvie Python Markus Gerber (Mitt elhäusern/CH), Remy Bruggmann (Bern/CH), Nicolas Ruggli Artur Summerﬁ eld (Mitt elhäusern, Bern/CH) 92 P�� II • T��, 14 S�� • 13:30–15:30

P501 Secreted CEA family members as immune regulators in the horse? Sophie Mißbach (Insel Riems, Greifswald, Götti ngen/DE), Jana Hänske, Denis Alecsic Lisa Blaschke (Insel Riems, Greifswald/DE), Wolfgang Zimmermann (Munich/DE) Johannes Handler (Berlin/DE), Robert Kammerer (Insel Riems, Greifswald/DE) P502 Use of PrimeFlow RNA assays for detecti on of cytokine mRNA and protein on the single cell level in chicken T cells – improvement of the available toolbox Julia Lagler (Vienna/AT), Fabienne Rauw, Benedicte Lambrecht (Brussels/BE) Dieter Liebhart, Wilhelm Gerner (Vienna/AT) P503 Suscepti bility of bona fi de dendriti c cells to porcine reproducti ve and respiratory syndrome virus Carmen Sautt er (Bern/CH), Gaël Auray, Obdulio García-Nicolás Artur Summerfi eld (Mitt elhäusern, Bern/CH) P504 Phenotypic and transcriptomic analysis of bovine dendriti c-cell subsets Stephanie Talker, Arnaud Baumann, Irene Keller, Remy Bruggmann Artur Summerfi eld (Bern/CH) P505 Trichuris suis chiti nase modulates unrelated infl ammati on Katja Balster, Friederike Ebner, Anna Vett er, Arnd Heuser, Susanne Hartmann (Berlin/DE) P506 Immunohistochemical study of cytokine profi le present in local immune response against hydati d cyst Mauricio Jiménez, F. Corrêa, C. Stoore, C. Hidalgo, C. González, R. Paredes (Santi ago/CL)

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Allergy P1–P9 p. 94 Neuroimmunology P261–P273 p. 94 Regulatory Immune Cells P300–P320 p. 96 T Cells II P395–P424 p. 97

Allergy P1 Costi mulatory signals through CD54/CD11a and CD58/CD2 are crucial for kerati nocyte-mediated T cell sti mulati on Christi an Orlik, Daniel Deibel, Emre Balta, Beate Niesler, Yvonne Samstag (Heidelberg/DE) P2 Group 5 allergens from house dust mites – similar structure with similar epitope positi on, a new perspecti ve for pepti de based immunotherapy lahiani Sadjia (Boumerdes/DZ), Moreno Galleni (Liege/BE) P3 Study of the interplay between a gammaherpesvirus infecti on and innate lymphoid cells in the context of type 2 immunity Pauline Loos, Bénédicte Machiels, Laurent Gillet (Liège/BE) P4 Anti body conjugates bi-specifi c for ICAM1 and allergens prevent epithelial penetrati on of allergens and rhinovirus infecti on Sabine Flicker, Isabella Ellinger, Eva Waltl, Katharina Blatt , Clarissa Cabauatan Kasia Niespodziana, Verena Niederberger, Peter Valent, Rudolf Valenta (Vienna/AT) P5 Parvalbumin-specifi c blocking IgG anti bodies protect against anaphylacti c reacti ons in a murine model of fi sh allergy Raphaela Freidl, Antonia Gstoett ner, Ulrike Baranyi, Ines Swoboda, Frank Stolz Margarete Focke-Tejkl, Thomas Wekerle (Vienna/AT), Ronald van Ree (Amsterdam/NL) Rudolf Valenta, Birgit Linhart (Vienna/AT) P6 Role of Somati c anti gens of Marshallagia marshalli on TLR4 expression in splenocytes o asthmati c mice Amin Zakeri, Hassan Borji, Alireza Haghparast, Mohamadreza Khakzad (Mashhad/IR) P7 Potent NLRP3 infl ammasome acti vati on by the HIV reverse-transcriptase inhibitor abacavir Ati ye Toksoy, Helga Sennefelder, Christi an Adam, Sonja Hofmann, Axel Trautmann Matt hias Goebeler, Marc Schmidt (Würzburg/DE) P8 Att enuated airway hyperresponsiveness and migrati on of dendriti c cells to the lungs and mediasti nal lymph nodes in absence of IL-17 in experimental asthma Adan Chari Jirmo, Mandy Busse, Kathleen Daluge, Christi ne Happle, Anika Habener Jelena Skuljec, Immo Prinz, Gesine Hansen (Hannover/DE) P9 The eff ect of chronic stress on contact dermati ti s Anna MacKerracher, Marcus Groett rup (Konstanz/DE)

Neuroimmunology P261 Eﬃ ciency of interferon alpha-2-b subcutaneous paraspinal injecti on in reducing of herniated disc ti ssue Alexander Tkachev, Alina Smirnova (Volgograd/RU) P262 Aorta brain circuits organize atherosclerosis immunity Sarajo Mohanta (Munich/DE), Li Peng (Xiamen/CN), Yuanfang Li Changjun Yin (Munich/DE), Thomas Mett enleiter (Riems/DE) Rainer Straub (Regensburg/DE), Christi an Weber, Andreas Habenicht (Munich/DE) P263 MHC-similarity determines level of agonisti c interacti ons in newly grouped piglets Ulrike Gimsa, Armin Tuchscherer, Birger Puppe (Dummerstorf/DE)

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P264 Pathogenicity of affi nity-purifi ed human autoanti bodies against myelin oligodendrocyte glycoprotein Melania Spadaro, Stephan Winklmeier, Caterina Macrini (Marti nsried/DE) Romana Höft berger (Vienna/AT), Elisabeth Schuh, Franziska Thaler, Lisa Ann Gerdes Sarah Laurent, Ramona Gerhards, Simone Brändle, Eduardo Beltran Klaus Dornmair, Gurumoorthy Krishnamoorthy (Marti nsried/DE) Dieter Jenne (Munich/DE), Reinhard Hohlfeld (Marti nsried/DE) Hans Lassmann Tania Kümpfel, Naoto Kawakami, Edgar Meinl (Marti nsried/DE) P265 Identi fi cati on of novel multi ple sclerosis associated immune checkpoint molecules by using high-throughput RNAi screen Ayse Nur Menevse, Antonio Sorrrenti no, Chih-Yeh Chen, Valenti na Volpin, Karin Holz Michaela Raab, Ursula Spirk, Till Michels, Philipp Beckhove (Regensburg/DE) P266 Dopamine receptors modulati on – a possible target for inducing new bone formati on in arthriti s Laura Salinas Tejedor (Dortmund/DE), Markus Rickert, Jürgen Steinmeyer (Giessen/DE) Stefan Rehart (Frankfurt/DE), Elena Neumann (Bad Nauheim/DE) Carsten Watzl (Dortmund/DE), Ulf Müller-Ladner (Bad Nauheim/DE) Silvia Capellino (Dortmund/DE) P267 IVIgs modulate the cytokine response of primary mouse microglia Larissa Jank, Tim Magnus, Björn Rissiek (Hamburg/DE) P268 Mathemati cal modeling of the Neuroendocrine-Immune (NEI) System in Rheumatoid Arthriti s (RA) Nima Amin, Sebasti an C. Binder, Ingo Schmitz (Braunschweig/DE) Georg Pongratz (Düsseldorf/DE), Jochen Triesch (Frankfurt/DE) Michael Meyer-Hermann (Braunschweig/DE) P269 A study of correlati on between complement, immunoglobulins and nitric oxide in Algerian myasthenia gravis pati ents Nadji Mohamed Bouchtout, Rachida Raache, Smail Daoudi, Sana Metatla Hayet Beloucif, Samir Meziche, Massinissa Lounis, Chafi a Touil-Boukoff a, Elyas Att al Nabila Att al (Algiers/DZ) P270 Single-cell profi ling reveals GPCR heterogeneity and functi onal patt erning during neuroinfl ammati on Denise Tischner, Myriam Grimm, Harmandeep Kaur, Daniel Staudenraus Jorge Carvalho, Mario Looso, Stefan Günther (Bad Nauheim/DE), Florian Wanke Sonja Moos, Nelly Siller (Mainz/DE), Johanna Breuer, Nicholas Schwab (Münster/DE) Frauke Zipp, Ari Waisman, Florian Kurschus (Mainz/DE), Stefan Off ermanns Nina Wett schureck (Bad Nauheim/DE) P271 CNS specifi c expression of IL-23 leads to exacerbati on and B cell accumulati on in the MP4 EAE model Simon Petzinna, Louisa Nitsch, Julian Zimmermann, Marius Krauthausen Marco Hessler, Michael Heneka (Bonn/DE), Iain Campbell (Sydney/AU) Stefanie Kürten (Erlangen/DE), Marcus Müller (Bonn/DE) P272 Generati on and characterizati on of pati ent-derived microglia-like cells for studying neuroinfl ammati on in Alzheimer’s disease Cira Dansokho, Michael Thomas Heneka (Bonn/DE) P273 A diff erenti al study of age of onset, AChR ti ters, and pathology form between both genders in Algerian myasthenia gravis pati ents Nadji Mohamed Bouchtout, Rachida Raache, Smail Daoudi, Sana Kechoud Fella Yala, Sofi a Merar, Chafi a Touil-Boukoff a, Elyas Att al, Nabila Att al (Algiers/DZ) 95 P�� III • F��, 15 S�� • 13:30–16:00

Regulatory Immune Cells P300 Human IL-4-treated mast cells acti vate phenotypically regulatoryB cells Felix Marsh-Wakefi eld, Angela Ferguson (Sydney/AU) Helen McGuire (Camperdown, Sydney/AU), Thomas Ashhurst, Gary Halliday (Sydney/AU) Michele A. Grimbaldeston (San Francisco, CA/US), Scott Byrne (Sydney/AU) P301 The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protecti on in murine crescenti c glomerulonephriti s Katrin Neumann, Annett Ostmann, Philippe Christophe Breda, Hans-Joachim Paust Ulf Panzer, Gisa Tiegs (Hamburg/DE) P302 Alloanti gen-specifi c regulatory T cells generated in presence of vitamin C display enhanced stability of Foxp3 expression and promote skin allograft acceptance Eirini Nikolouli (Braunschweig/DE), Matt hias Hardtke-Wolenski Marti n Hapke (Hannover/DE), Michael Beckstett e, Robert Geff ers Stefan Floess (Braunschweig/DE), Elmar Jaeckel (Hannover/DE) Jochen Huehn (Braunschweig/DE) P303 A regulatory phenotype is induced in CD4+ T cells by GARP expressing platelets Niklas Zimmer, Susanne Hahn, Elena Walter, Kersti n Jurk, Andrea Tuett enberg (Mainz/DE) P305 Endogenous expression of the human CD83 protein att enuates EAE symptoms in transgenic mice Elisabeth Zinser (Erlangen/DE), Ronald Naumann (Dresden/DE), Julia Michalski Andrea Deinzer, Lena Sandrock, Christi ne Kuhnt, Alexander Steinkasserer Ilka Knippertz (Erlangen/DE) P306 Retnla-Cre mice – a novel M2-reporter mouse model Branislav Krljanac, David Vöhringer, Christoph Koch (Erlangen/DE) P307 Human double-negati ve regulatory T cells selecti vely suppress mTOR signaling and metabolic reprogramming of conventi onal T cells Tabea Haug, Michael Aigner, Carolin Strobl, Heiko Bruns, Andreas Mackensen Simon Völkl (Erlangen/DE) P308 Roles of selecti ve molecular factors in the development of stableFoxp3+ regulatory T cells Susanne Herppich, Garima Garg, Aras Toker, Jochen Hühn (Braunschweig/DE) P309 CD83 expression in human conventi onal CD4+ and regulatory CD4+CD25+ T cells Vera Assmann (Erlangen/DE), Petra Hoff mann, Matt hias Edinger Michael Rehli (Regensburg/DE), Marcello Stein, Andrea Deinzer, Julia Michalski Alexander Steinkasserer, Ilka Knippertz (Erlangen/DE) P310 The guanine-nucleoti de exchange factor CalDAG GEFI fi ne-tunes regulatory T cell functi on Jana Niemz (Braunschweig/DE), Stefanie Kliche (Magdeburg/DE), Christi an Freund Eliot Morrison, Annika Manns (Berlin/DE), Jill R Critt enden Ann M Graybiel (Cambridge, MA/US), Lothar Jänsch, Jochen Huehn (Braunschweig/DE) P311 Heterogeneity of IL-10 producing Foxp3- T cells Leonie Brockmann, Babett Steglich, Shiwa Soukou, Lilan Zhao, Amanda Pleßmann Nicola Gagliani, Samuel Huber (Hamburg/DE) P312 A stable subset of human Treg with minimal overlap to conventi onal T cells Anna Nowak, Petra Bacher, Thordis Hohnstein, Katrin Vogt, Birgit Sawitzki (Berlin/DE) Pascal Giehr, Judith Gottf reund (Saarbrücken/DE), Julia K. Polansky, Alf Hamann Laura Lozza, Manuela Stäber (Berlin/DE), Nina Babel (Berlin, Bochum/DE) Mikalai Nienen, Ulrik Stervbo (Bochum/DE), Jörn Walter (Saarbrücken/DE) Alexander Scheff old (Berlin/DE)

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P313 Impairment of hypothalamic immune homeostasis by high-caloric feeding Maike Becker, Stefanie Kälin, Victoria K. Flynn, Verena B. Ott , Isabelle Serr Marti n G. Scherm (Munich/DE), Fabian Hosp (Marti nsried/DE) Chun-Xia Yi (Amsterdam/NL), Anett e-Gabriele Ziegler (Munich/DE) Ingo Bechmann (Leipzig/DE), Matt hias Mann (Marti nsried/DE), Matt hias H. Tschöp Carolin Daniel (Munich/DE) P314 Proliferati on-independent GM-CSF and M-CSF signals control monocyte conversion into monocyti c myeloid-derived suppressor cells Eliana Ribechini (Würzburg/DE), James A. Hutchinson (Regensburg/DE) Sabine Hergovits, Marion Heuer, Jörg Lucas (Würzburg/DE) Ulrike Schleicher (Erlangen/DE), Ana-Laura Jordán Garrote Sarah J. Pott er (Würzburg/DE), Paloma Riquelme (Regensburg/DE), Heike Brackmann Nora Müller (Würzburg/DE), Hartmann Raifer (Marburg/DE) Ingolf Berberich (Würzburg/DE), Magdalena Huber (Marburg/DE) Andreas Beilhack (Würzburg/DE), Michael Lohoff (Marburg/DE) Christi an Bogdan (Erlangen/DE), Matt hias Eyrich, Heike M. Hermanns (Würzburg/DE) Edward K. Geissler (Regensburg/DE), Manfred B. Lutz (Würzburg/DE) P315 Treg depleti on does not aff ect outcome in experimental stroke regardless of animal age Juliane Schulze, Jens-Peter Kühn, Katrin Schmoeckel, Barbara M. Bröker (Greifswald/DE) Alexander Dressel (Cott bus/DE), Antje Vogelgesang (Greifswald/DE) P316 Modulati on of human gamma/delta T cell acti vati on by vitamin C Léonce Kouakanou, Christi an Peters, Dieter Kabelitz (Kiel/DE) P317 Dendriti c cells induced CD4+Foxp3+ regulatory T cells via release of TGF-β in mesenteric lymph nodes of murine LPS-induced tolerance model Jia Lu, Li Jia, Ya Zhou, Yijing Tao, Hualin Xu, Juanjuan Zhao, Mengmeng Guo, Chao Chen Lin Xu (Zunyi/CN) P318 Phenotypical characterizati on of IL-10 producing regulatory B cell subsets Vu Huy Hoang Duong, Jinbo Yu, Marti na Krautkrämer, Niko Föger Kyeong-Hee Lee (Hannover/DE) P319 The cell surface molecule Toso exhibits B cell-inherent immunoregulatory functi on on T cell immunity during viral infecti on Jinbo Yu, Katrin Westphal, Niko Föger, Kyeong-Hee Lee (Hannover/DE) P320 Comparati ve transcripti onal profi ling of human blood and liver resident CD4+ regulatory T cells Kim-Long Truong, Stephan Schlickeiser, Katrin Vogt, David Boës, Katarina Stanko Christi ne Appelt, Mathias Streitz, Andreas Pascher, Igor Sauer, Undine Gerlach Birgit Sawitzki (Berlin/DE)

T Cells II P395 CTLA-4 mediated eﬀ ects on STATs regulate diﬀ erenti ati on and plasti city of Tc17 cells Aditya Arra, Holger Lingel (Magdeburg/DE), Benno Kuropka (Berlin/DE) Thomas Fischer (Magdeburg/DE), Christi an Freund (Berlin/DE), Mandy Pierau Monika Brunner-Weinzierl (Magdeburg/DE) P396 Respirasome dynamics and turnover in acti vated T lymphocytes Daniel Meston, Lothar Jänsch, Ralf Mendel, Tobias Kruse (Braunschweig/DE) P397 In vivo expansion of regulatory T cells during the acute phase of experimental anti -GBM GN ameliorates kidney damage Stefanie Klinge (Hamburg/DE), Helmut Hopfer (Basel/CH) Hans-Willi Mitt rücker (Hamburg/DE) 97 P�� III • F��, 15 S�� • 13:30–16:00

P398 Human mucosal-associated invariant T cells in age-associated Clostridium diffi cile i n f e c ti o n s Isabel Bernal (Magdeburg/DE), Björn Bulitt a, Meina Neumann-Schaal Dietmar Schomburg (Braunschweig/DE), Dunja Bruder (Magdeburg, Braunschweig/DE) Lothar Jänsch (Braunschweig/DE) P399 HDAC7 regulates CD8+ T cell memory diff erenti ati on Jacqueline Keye, Carl Weidinger, Sibel Durlanik, Franziska Schmidt Alberto Japp, Désirée Kunkel, Rainer Glauben, Britt a Siegmund (Berlin/DE) P400 T cell-specifi c Bcl6 is required for the maintenance of T follicular helper cells and germinal centers Dominik Alterauge, Dirk Baumjohann (Planegg-Marti nsried/DE) P401 Is the progression from NAFLD to NASH caused by misguided interacti on between the dysbioti c intesti nal microbiota and multi -cytokine producing CD4 T cells? Pasquale Scognamiglio, Ramez Wahib, Lilan Zhao, Nicola Schaltenberg Theodora Agalioti , Leonie Brockmann, Anastasios D. Giannou, Bianca T. Hofmann Stefan Wolter, Oliver Mann, Jakob R. Izbicki, Ansgar W. Lohse, Samuel Huber Nicola Gagliani (Hamburg/DE) P402 Computati onal predicti on and modeling of T-cell receptor-pepti de-MHC interacti ons Iris Antes, Thomas Hoff mann, Markus Schneider, Manuel Glaser (Freising/DE) P403 Circular RNA in proinfl ammatory T helper lymphocytes Gitt a Anne Heinz, Cam Loan Tran, Pawel Durek, Frederik Heinrich, Zhuo Fang Claudia Haft mann, Vanessa Treff ner, Wei Chen, Nikolaus Rajewsky Hyun-Dong Chang, Andreas Radbruch, Mir-Farzin Mashreghi (Berlin/DE) P405 Glutathione primes T cell metabolism for infl ammati on Melanie Grusdat, Dirk Brenner (Esch-sur-Alzett e/LU), Tak W. Mak (Toronto/CA) P406 CD2 induced predominant Th1 response could be a potenti al immunotherapeuti c strategy to combat visceral Leishmaniasis infecti on Sukrat Sinha, Shanthy Sundaram (Allahabad/IN) P407 Microbe-reacti ve anti gen-presenti ng γδ T-cells sti mulate human CD4+ T-cell responses disti nct from those induced by conventi onal APCs Chris Tyler (Cardiff /GB), Neil McCarthy, James Lindsay, Andrew Stagg (London/GB) Bernhard Moser, Matt hias Eberl (Cardiff /GB) P408 Structural and functi onal analysis of IRF4 in T-cell diff erenti ati on Daniel Staudenraus, Cholho Kang, Michael Lohoff (Marburg/DE) P409 Temporarily depleted versus consti tuti vely defi cient – a new mouse model to conditi onally deplete γδ T-cells Inga Sandrock, Annika Reinhardt, Immo Prinz (Hannover/DE) P410 Visualizing γδ T cell interacti ons with nocicepti ve sensory neurons and epithelial cells in vivo Annika Reinhardt, Inga Sandrock, Immo Prinz (Hannover/DE) P411 Versati lity of lysosome-related eff ector compartments in human T-cell populati ons governs the diff erenti al mobilizati on of cytotoxic eff ector proteins Marcus Lett au, Michelle Dietz, Katharina Dohmen, Fred Armbrust, Tobias Poch Lisann Drews, Ott mar Janßen (Kiel/DE) P412 Morphological and biochemical characterizati on of eff ector compartments of cytotoxic T lymphocytes Michelle Dietz, Lisann Drews, Katharina Dohmen, Ott mar Janßen Marcus Lett au (Kiel/DE) 98 P�� III • F��, 15 S�� • 13:30–16:00

P413 MicroRNA-126 defi ciency aff ects the development of thymus CD4+SP cells through elevati ng IRS-1 Hualin Xu, Jia Lu, Ya Zhou, Wen Zheng, Liangyu Lei, Juanjuan Zhao, Mengmeng Guo Chao Chen, Lin Xu (Zunyi/CN) P414 Modulati ng Treg resistance in autoimmune diseases – new treatment for multi ple sclerosis pati ents improves T cell sensiti vity towards Treg-mediated suppression Janine Schlöder, Carsten Berges, Felix Luessi, Helmut Jonuleit (Mainz/DE) P415 Endocytosis of cytotoxic granules is essenti al for multi ple target cell killing by cytotoxic T lymphocytes Hsin-Fang Chang, Hawraa Bzeih, Claudia Schirra, Praneeth Chiti rala, Elmar Krause Jens Retti g, Varsha Patt u (Homburg/DE) P416 Dynamin2 regulates human T lymphocyte adhesion and integrin clustering via the acti vati on of the small GTPase Rap1 Felix Eppler, Thomas Quast, Waldemar Kolanus (Bonn/DE) P417 S1P-mediated emigrati on of mature thymocytes into the circulati on depends on ceramide synthase 2 Michael Rieck, Christi ane Kremser, Katarzyna Jobin, Elisabeth Mett k Christi an Kurts (Bonn/DE), Markus Gräler (Jena/DE), Klaus Willecke Waldemar Kolanus (Bonn/DE) P418 Cytohesin-3 and its interacti on partner Arl4d control T cell-mediated immunity against viral infecti ons by regulati ng IL-2 producti on Felix Tolksdorf (Bonn/DE), Linda Diehl (Hamburg/DE), Julita Kaczmarek, Jessica Grell Bianca Paul (Bonn/DE), Percy A. Knolle (Munich/DE), Waldemar Kolanus (Bonn/DE) P419 ADP-ribosylati on of P2X7 during cell preparati on aff ects the vitality of liver ti ssue resident memory T cells Björn Rissiek, Marco Lukowiak, Stephan Menzel, Nicole Schwarz, Friedrike Raczkowski Daniel Reimers, Hans-Willi Mitt rücker, Tim Magnus, Friedrich Koch-Nolte (Hamburg/DE) P420 The adapti ve immune system is diff erent involved in high fat high carbohydrate diet induced non-alcoholic Steatohepati ti s (NASH) in BALB/c and C57BL/6 mice Janine Dywicki (Hannover/DE), Jerome Schlué, Christi ne Falk (Hannover/DE) Benjamin Heidrich, Elmar Jäckel, Matt hias Hardtke-Wolenski (Hannover/DE) P421 Modulati on of eff ector functi ons of allergen-specifi c T cells by the PDK-1 and TBK-1 targeti ng drug BX795 Peter Tauber, Marti n Candia, Doris Trapin, Alina Neunkirchner, Sabrina Jutz Peter Steinberger, Winfried Pickl (Vienna/AT) P422 Trypanosoma cruzi escapes eliminati on through the inducti on of co-inhibitory receptors on T cells Rosa Isela Grote-Gálvez, Thomas Jacobs (Hamburg/DE) P423 T cell response to high anti gen in the liver is regulated by NK and Kupff er cells Kingsley Kumashie, Marcin Cebula, Dagmar Wirth (Braunschweig/DE) P424 Memory T cell maintenance and self-renewal depend on conti nuous FOXO1 expression Daniel T. Utzschneider, Arnaud Delpoux, Xin Huang, Chen-Yen Lai Stephen M. Hedrick (San Diego, CA/US)

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Abstract Volume The abstracts of the DGfI meeti ng are published online at www.immunology-conference.de (under “Abstracts”). Please note that they are only accessible for parti cipants of the conference.

Should you be interested in a printed editi on for 25 EUR per copy, please ask at the check-in for availability.

Catering During coff ee breaks we are pleased to provide parti cipants with coff ee, tea, water and snacks. Please note that catering will only be served within the exhibiti on area on the ground and fi rst fl oor. Water dispensers are placed at various points within the exhibiti on.

During lunch breaks you are welcome to visit one of the industrial lunch symposia, where the companies oﬀ er free catering, or have a snack in the exhibiti on area on the ground ﬂ oor. For a bett er orientati on, please have a look at page 110 f. (plan of exhibiti on and posters).

Certi fi cate of Att endance Your certi fi cate of att endance, as well as the certi fi cate from the medical chamber (“Landesärztekammer”) of the state of Bavaria, will be available for down- load via a personal link which the organizers will send you aft er the congress.

Child Care Service The DGfI oﬀ ers a child care service during the congress hours: AGB Tuesday Wednesday Thursday Friday 14:00–20:15 08:00–19:15 08:00–19:15 08:00–19:15

Please contact us via [email protected] prior to the congress or contact our check-in staﬀ onsite.

This service is organized by the DGfI Young Immunologists and kindly sponsored by Beckman Coulter, Inc.

Educati on Credits and Certi fi cati on An applicati on to certi fy the 47th Annual Meeti ng of the German Society for Im- munology is submitt ed to the Medical Chamber of the State of Bavaria (Landesär- ztekammer). For certi fi cati on all att endees are required to scan their barcode twice a day at the certi fi cati on stati on near the check-in.

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General Terms and Conditi ons Please ﬁ nd our general terms and conditi ons on the conference website GTC www.immunology-conference.de.

Internet Wireless internet is available throughout the conference venue:

SSID dgﬁ 2017 Password dgﬁ meeti ng

Opening Hours Tuesday Wednesday Thursday Friday Check-in 08:00–20:00 07:30–19:00 08:00–19:30 08:00–18:30 Media check-in 08:00–19:30 07:30–17:30 08:00–19:00 08:00–17:30 Internet lounge 08:00–20:00 07:30–17:30 08:00–19:00 08:00–16:00 Exhibiti on 14:30–21:30 10:30–17:30 10:30–17:30 10:30–16:00 Posters 17:30–20:00 08:00–19:00 08:00–19:00 08:00–16:00

Online Program For current detailed informati on regarding the scienti ﬁ c program please have a look at our online program at htt p://programm.conventus.de/dgﬁ 2017. Compose your individual program and review it at any ti me on your way.

Poster Prizes The best posters will be selected for a poster prize. The awards will be presented aft er the poster session III on Friday, 15 September from 16:00–17:00 in “Großer Saal”. All potenti al awardees will be informed in ti me and are kindly asked to att end the award ceremony. Please check your e-mail account for noti ﬁ cati on.

Public Transport The Heinrich-Lades-Halle is located in the town centre of Erlangen. Erlangen main stati on is within walking distance (10 minutes). The local buses have a fre- quent and punctual schedule connecti ng all areas in and around Erlangen. The closest bus stop to the congress venue is “Erlangen Neuer Markt”, which con- nects to the main stati on.

Tickets are available in the busses as well as at the bus stops.

For further informati on on public transport and ti metables visit either www.vgn.de or www.bahn.de.

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Registrati on Fees Regular Member DGfI 435 EUR Non-Member 550 EUR

Students/Doctoral candidates* Member DGfI 170 EUR Non-Member 185 EUR

Abstract book (printed) 25 EUR

Day Tickets Tuesday Wednesday Thursday Friday Regular Member DGfI 115 EUR 165 EUR 165 EUR 115 EUR Non-member 165 EUR 210 EUR 210 EUR 165 EUR

Students/Doctoral candidates* Member DGfI 45 EUR 80 EUR 80 EUR 45 EUR Non-member 60 EUR 95 EUR 95 EUR 60 EUR

Social Program Tuesday, 12 September Welcome recepti on – conference parti cipant included Welcome recepti on – accompanying person 20 EUR

Wednesday, 13 September Young immunologists science-dati ng at own expense (Kitzmann BräuSchänke)

Friday, 15 September Social evening – Students/Doctoral candidates* 40 EUR Social evening – regular 60 EUR Social evening – accompanying person 60 EUR Promenade ti ckets (entrance from 21:30) 30 EUR

* Please provide proof of status

102 DAS NEUE trillium FACHMAGAZIN immunologie

Wir bringen das große öﬀ entliche Interesse an immun ologisch-medizinischen Fragestellungen mit hoher wissenschaftlicher Komplexität in Einklang – von Infektionskrankheiten und Vakzinen über Allergien und rheumatische Erkrankungen bis hin zur Onkologie und Genetik. Die Zeitschrift soll der praxisnahen Fortbildung und Wissensvermittlung für Ärzte und Naturwissenschaftler dienen und die Inhalte der Immunologie über die eigenen fachlichen Grenzen hinaus auf breiter Basis trilli bekannt machen. immunologieum

Jubiläumsausgabe der Deutschen Gesellschaft für Immunologie e. V.

ISSN 2513-1583 | www.trillium.de 2017 | Band 1 | Heft 1

ImmunonkologieSCHWERPUNKT

Checkpoint-Inhibitoren WEITERE THEMEN CRISPR/Cas9CARs: in der Designer-T-Zellen Immunologie 50 Jahre DGfI Tuberkulose: Vergessen, Vom Antitoxin zum monoklonalen Antikörper aber nicht besiegt Nukleinsäure-Immunität Nachwuchs & Ausbildung Forschung & Arbeitskreise

Weitere Informationen und (Probe-) Abonnement unter www.trillium.de

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Media Check-in There will be a central Media check-in on site, where you can upload your talks.

Opening hours Tuesday Wednesday Thursday Friday 08:00–19:30 07:30–17:30 08:00–19:00 08:00–17:30

We strongly encourage you to upload your presentati on onto our central computer on-site well in advance of the session in which you are speaking. The latest you should have your presentati on uploaded on the appropriate computer is 30 minutes before the start of your session. If you are speaking in the fi rst session of the day, we encourage you to upload your presentati on the evening before. You will have the possibility to view and edit your presentati on on site. For submission, please use a USB fl ash drive which should not be protected with soft ware. In preparati on for uploading your presentati on onto the computer, please name your fi le as follows: DAY.TIME.LASTNAME.ppt. If your presentati on includes additi onal fi les, such as a video fi le embedded in your PPT, please make sure that these fi les work properly and are available for transfer. Please note: Do not rely on having internet access available during your talk.

Submitti ng your Presentati on Please prepare your presentati on in 16:9 aspect rati o. A presentati on notebook with a PDF reader and MS Oﬃ ce PowerPoint 2016 will be provided. The use of personal notebooks is possible – a technical supervisor will help you. Please provide an adapter for VGA if necessary. A notebook, presenter and laser pointer are available at the speaker’s podium in each lecture hall.

Poster Sessions The poster sessions are scheduled as follows: Poster Session I Wednesday, 13 September 13:30–15:30 Poster Session II Thursday, 14 September 13:30–15:30 Poster Session III Friday, 15 September 13:30–16:00

Posters should be DIN A0 (84.1 cm x 118.9 cm, not laminated). Poster pin boards are 120 cm x 150 cm. They are only to be used with the designated pins available at each poster board. Pin boards will be numbered. Poster presenters are asked to be present at their poster during their poster session.

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The following poster presentati ons will be held during the sessions:

Poster Session III • Friday, 15 September • 13:30–16:00 Allergy P1–P9 p. 94 Neuroimmunology P261–P273 p. 94 Regulatory Immune Cells P300–P320 p. 96 T Cells II P395–P424 p. 97

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Display and Removal of Posters The posters for poster session I can be displayed from Tuesday to Wednesday. You may hang up your poster on Tuesday, 12 September from approx. 17:30 at the assigned poster wall and remove it on Wednesday, 13 September by 16:00 at the latest. All posters that are sti ll hanging aft er that will be considered as waste. Posters will not be redirected.

The posters for poster session II and poster session III can be displayed from Thursday to Friday. You may hang up your poster on Thursday, 14 September from approx. 7:30 at the assigned poster wall and remove it on Friday, 15 Sep- tember by 16:30 at the latest. All posters that are sti ll hanging aft er that will be considered as waste. Posters will not be redirected.

Time Allotment Presentati ons ti mes have been assigned: Invited speaker presentati ons 25 min + 5 min discussion Oral presentati ons (workshops) 10 min + 5 min discussion Oral presentati ons (B cell workshop) 10 min + 3 min discussion Oral presentati ons (Complement workshop) 9 min + 2 min discussion

For the length of your oral presentati on, please refer to the e-mail conﬁ rmati on. To ensure the smooth running of the enti re program, all speakers are requested to adhere to their allocated speaking ti me. The session chairs are encouraged to inform the speaker of any delays and may interrupt if necessary.

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We would like to thank the following companies and partners for their support:

Main Sponsors AYOXXA Biosystems GmbH (Cologne/DE)

Miltenyi Biotec GmbH (Bergisch Gladbach/DE)

Sysmex Deutschland GmbH (Norderstedt/DE)

Takara Bio Europe (Saint-Germain-en-Laye/FR)

Sponsors of a Lunch Symposium 10X Genomics (Pleasanton, CA/US)

Agilent Technologies Sales & Service GmbH & Co. KG. (Waldbronn/DE)

AYOXXA Biosystems GmbH (Cologne/DE)

Foundati on Acteria (Zurich/CH)

Miltenyi Biotec GmbH (Bergisch Gladbach/DE)

NanoString Technologies Germany GmbH (Hamburg/DE)

Takara Bio Europe (Saint-Germain-en-Laye/FR)

Sponsors of Poster Session Progen Biotechnik GmbH (Heidelberg/DE)

Sponsor President’s Symposium Luminex B.V. (Hertogenbosch/NL)

Sponsor President’s Dinner BioLegend UK Ltd. (London/GB)

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38 10x Genomics (Pleasanton, CA/US) 43 Acris Anti bodies - OriGene EU (Herford/DE) 36 Adapti ve Biotech (Schwetzingen/DE) 13 Agilent Technologies Sales & Service GmbH & Co. KG. (Waldbronn/DE) 49 AID GmbH (Strassberg/DE) 10 ALK-Aelló Arzneimitt el GmbH (Hamburg/DE) 5 Analyti k Jena AG (Jena/DE) 46 AYOXXA Biosystems GmbH (Cologne/DE) 59 Beckman Coulter GmbH (Krefeld/DE) 40 Becton Dickinson GmbH (Heidelberg/DE) 37 BioLegend (San Diego, CA/US) 19 BIOMOL GmbH (Hamburg/DE) 4 Bio-Rad Laboratories (Oxfordshire/GB) 17 Bio-Techne (Abingdon/GB) 41 Biozol Diagnosti ca Vertrieb GmbH & Innova Biosciences Ltd. (Eching/DE) 39 Biozym Scienti ﬁ c GmbH (Hessisch Oldendorf/DE) 3 CeMet GmbH (Tübingen/DE) 50 Charles River Laboratories, Research Models and Services, Germany GmbH (Sulzfeld, Grabfeld/DE) 27 ChemoMetec GmbH (Kaiserslautern/DE) 34 Cisbio (Codolet/FR) 2 Cluster of Excellence ImmunoSensati on (Bonn/DE) 52 CTL Europe GmbH (Bonn/DE) 23 DGfI (German Socielty for Immunology) 9 EFIS/ECI 2018 (Vienna/AT) 54 Eurogentec S.A. (Seraing/BE) 26 FlowJo LLC (Ashland, OR/US) 12 FLUIDIGM (Munich/DE) 1 Genscript (Piscataway, NJ /US) 20 Greiner Bio-One GmbH (Frickenhausen/DE) 31 HISS Diagnosti cs GmbH (Freiburg/DE) 58 Hölzel Diagnosti ka Handels GmbH (Cologne/DE) 48 IBA Lifesciences (Götti ngen/DE) 25 Informati onsiniti ati ve „Tierversuche verstehen“ der Allianz der Wissenschaft sorganisati onen (Münster/DE) 18 Invivogen (Toulouse/FR) 35 Jackson ImmunoResearch Europe Ltd. (Newmarket/GB) 7 LaVision BioTec GmbH (Bielefeld/DE) 42 LGC Standards GmbH (Teddington, Middlesex/GB) 14 Lonza Cologne GmbH (Cologne/DE) 6 Mabtech AB (Nacka Strand /SE) 55 Meso Scale Diagnosti cs, LLC. d/b/a Meso Scale Discovery (Rockville, MD/US) 24 MICE (Medical Immunology Campus Erlangen) 45 Miltenyi Biotec GmbH (Bergisch Gladbach/DE) 108 E�� (��)

30 NanoString Technologies Germany GmbH (Hamburg/DE) 22 New England BioLabs GmbH (Frankfurt/DE) 56 OLS OMNI Life Science GmbH & Co KG (Bremen/DE) 47 PEPperPRINT GmbH (Heidelberg/DE) 44 pepti des&elephanst GmbH (Henningsdorf/DE) 32 PromoCell GmbH (Heidelberg/DE) 11 Proteintech Europe Ltd. (Manchester/GB) 21 Sarstedt AG & Co. (Nümbrecht/DE) 28 Sino Biological Inc. (Beijing/CN) 57 Sony Europe Ltd. (Weybridge, Surrey/GB) 29 STEMCELL Technologies Germany GmbH (Cologne/DE) 51 Sysmex Deutschland GmbH (Norderstedt/DE) 33 Takara Bio Europe (Saint-Germain-en-Laye/FR) 60 Thermo Fisher Scienti ﬁ c (Paisley/GB) 53 TissueGnosti cs GmbH (Vienna/AT)

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ELSEVIER | Health and Medical Science Journals (Philadelphia, PN/US) Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology: In Practi ce

S. Karger Verlag für Medizin und Naturwissenschaft en GmbH (Freiburg/DE) Transfusion Medicine and Hemotherapy

TRILLIUM GmbH (Grafrath/DE) Trillium Diagnosti k

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109 P�� E�� P�� • G�� F�� You are here are You 7 14 6 Check-in, wardrobe 13 5 conference bags, conference Restrooms 12 4 11 3 10 2 9

Certification 1 17 DGfI

25 50 years

24 39 20 21 19 26 38 33 32 18 22 48 51 32 27 31 37 34 47 49 28 30 36 35 53 52 54 29 46 50 45 55 56 41 43 42 40 44 57 59 58 60 Kleiner Saal

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3+4

Konferenz 5

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Welcome Recepti on and Meet the Exhibitors Be our guest and round oﬀ the evening with some ﬁ nger- food and a glass of wine. Meet your colleagues, friends and industrial partners in a relaxed atmosphere.

Date Tuesday, 12 September Time 20:15–21:30 © 111745888 l Rawpixel.com l Fotolia.com Locati on Heinrich-Lades-Halle • Industrial exhibiti on

Scienti ﬁ c Plenary Debate followed by Social Evening Date Friday, 15 September Time 19:30–2:00 party unti l 4:00 with beverages at own cost from 2:00–4:00 Venue Locati on “E-Werk” • Fuchsenwiese 1 91054 Erlangen © 41761122 l CandyBox Images l Fotolia.com Meeti ng point 19:00 (aft er the Closing lecture) in the foyer of the main entrance within 15 minutes walking distance from the congress venue Please bring your name badge! Please note that you have to arrange the return from the social evening by yourself.

Dear guests, the locati on for the evening is the cultural center “E-Werk”. It is a former electrical generati ng stati on, being in use since 35 years, before it became the cultural center of Erlangen. We open 3 fl oors for the dinner, off ering various styles of music. - great hall with band “Tough Talk” - “Kellerbühne” with JazzBand “Cheers” - Club lounge with DJ Gack (closing at 21:45) Buff et and bars are installed in every room. from 19:15 entrance to E-Werk from 19:45 Welcome by conference president and dinner buff et from 21:30 entrance for promenade ti cket holders from 21:45 Scienti fi c plenary debate Marti n Hermann (Erlangen/DE)) and Reinhard Voll (Freiburg/DE) from 22:15 Great hall: Party with Tough Talk and DJ Gack Kellerbühne: Jazz music by “Cheers” 2:00–4:00 beverages at own expense 4:00 end of event

Fee (incl. buﬀ et, drinks and band unti l 2:00) Regular, acc. person 60 EUR Students/Doctoral candidates 40 EUR Promenade ti ckets (entrance from 21:30) 30 EUR 112 I�� C��, I�� S�� P�� A�� A��

A Abdirama, D. 81 Bedoui, S. 48 Brunner, C. 73, 78, 79 Abdullah, Z. 24, 63 Beer-Hammer, S. 71 Bruns, H. 64, 70, 74, 96 Abel, A. 71, 72 Behrendt, R. 31, 64 Brüstle, A. 51 Acosta Rodriguez, E. 14 Bellmàs Sanz, R. 27, 72 Buchholz, V. R. 48 Adamczyk, A. 60, 66 Bénard, A. 85 Buckley, C. 35, 81 Ahmetspahic, D. 61 Berberich-Siebelt, F. 22 Bufe, B. 49 Akira, S. 34 Berkhout, L. 67, 81 Burkhardt, l. 71 Albrecht, M. 16 Bernal, I. 98 Burmester, G.-R. 35, 81 Ali, S. 83 Bernhardt, A. L. 56 Burnett , D. 19 Alix, P. 92 Berod, L. 14 Busch, D. H. 22 Almanzar, G. 59 Bertolotti , M. 79 Busch, K. 22 Al-Naimi, F. 74 Beyersdorf, N. 44, 70, 71 Busse, M. 78, 94 Alterauge, D. 98 73, 82 Butt gereit, A. 20 Altf eld, M. 85, 88 Bhatt acharjee, S. 63, 86 Amin, N. 95 Bi, W. 68 C Amsberg, N. 70 Bieber, K. 83 Capellino, S. 51, 95 Anderson, S. 42 Bitar, M. 62 Cascalho, M. 39, 58 Andes, F. 59 Bitschar, K. 66, 85 Cassatella, M. A. 23 Andreas, N. 43, 90 Blank, A. 49 Cavallari, M. 19, 58 Andreev, D. 80 Blume, J. 43, 69 Cendón, C. 71 Anisiewicz, A. 90 Bogdan, C. 18, 44, 58, 85, 86 Cerwenka, A. 35 Anliker, M. 82 87, 89, 97 Chang, H.-D. 31, 69, 71, 79 Antes, I. 98 Bohmann, S. 66 89, 98 Aribi, M. 60 Bohn, T. 43 Cheng, Q. 79 Arlt, A. 74 Bonifacius, A. 70, 71, 74 Choucair, J. 76 Arra, A. 97 Böning, M. 68 Cicin-Sain, L. 48 Aschenbrenner, A. C. 89 Bopp, T. 37 Ashour, D. 84 Bordbari, S. 64, 74 D Assmann, V. 96 Borkner, L. 64 da Costa, C. 24 Atschekzei, F. 62 Bornemann, L. 68 Dabrowski, A. 64 Auray, G. 92, 93 Borte, S. 15, 62 Dallenga, T. 24 Autenrieth, S. E. 36, 43, 83 Bösl, K. 86 Dalpke, A. 30, 65, 66 Bosnjak, B. 64 Damanhouri, L. 69 B Bossaller, L. 81 Dansokho, C. 95 Bachem, A. 25 Bött cher, C. 51 Dasari, P. 39, 82 Bacher, P. 20, 24, 96 Bött cher, M. 67, 70, 74 Daum, P. 57, 58 Bachmann, M. 88 Bourouba, M. 74 de Oliveira, J. R. 64 Baien, S. 92 Brand, A. 60 Delacher, M. 69 Balster, K. 93 Brand, M. 79 Deloch, L. 59 Balta, E. 67, 70, 94 Brandenburg, J. 36 Denk, S. 82 Barth, S. 87 Breda, P. C. 56, 96 Dennstädt, F. 71 Barthel, R. 69 Bremer, L. 59 Di Cristanziano, V. 73 Basler, M. 25, 56, 90 Brenner, D. 29, 98 Dietschmann, A. 85 Baßler, K. 41, 89 Brewitz, A. 20 Dietz, M. 98 Baumann, T. 67 Brinkmann, K. 79 Dietze-Schwonberg, K. 19 Baumgrass, R. 66 Broadley, S. 39 Döbbeler, M. 59, 70 Baumjohann, D. 41, 69, 84, 98 Brockmann, L. 96, 98 Dorhoi, A. 36 Becker, M. 97 Brown, G. 35 Dörrie, J. 69, 75, 84 Bedke, T. 29, 66 Brümmendorf, T. 15 Dreschers, S. 65 113 I�� C��, I�� S�� P�� A�� A��

Dressel, R. 60 Frasconi, T. 49 Hammer, Q. 42 Drube, S. 90 Freidl, R. 94 Hammer, S. 92 Dudeck, A. 16, 43, 84, 87, 90 Frey, B. 59, 73, 76 Hammerich, L. 25 Dudek, M. 71 Friedrich, K. 68 Hanitsch, L. 15 Dudziak, D. 17, 43, 57, Fritz, B. 40 Hannemann, N. 89 59, 75, 83 Frueh, J. 73 Hansen, M. 89 Dywicki, J. 99 Fu, J. 27 Hänske, J. 44, 93 Fülle, L. 51 Harberts, A. 37 E Füllsack, S. 89 Harrer, T. 63, 69 Eberhardt, M. 88, 89 Härtle, S. 44, 92 Eberl, G. 44 G Hartmann, G. 48 Eberl, M. 98 García-Nicolás, O. 76, 93 Hartmann, K. 28 Eberle, J. U. 59 Garg, G. 50, 96 Hartmann, W. 24 Eibel, H. 38, 62, 78 Gebhardt, T. 24, 42 Haub, J. 31 Elfaki, Y. 50 Gerer, K. F. 75, 84 Haug, T. 56, 96 ElFiky, A. 71 Gerlach, K. 37 Hauptmann, M. 30 El-Helou, S. M. 62 Ghosh, M. 56 Hauser, A. 34 Elsayed, H. 75 Gieras, A. 31 Hayet, R. 91 Emler, T. 62 Gilles, S. 16 Heger, L. 43, 59, 83 Enders, A. 26 Gimsa, U. 51, 94 Heidkamp, G. 83 Enders, M. 25, 52 Godfrey, D. I. 23 Heilingloh, C. 63 Engels, N. 16, 79 Golnik, R. 57 Hein, R. 72 Eppler, F. 99 Gondorf, F. 66 Heine, G. 49, 58, 79 Eskandarian, Z. 62 Gonzalez-Hilarion, S. 27 Heinemann, J. 58 Esser, P. 16 Goodnow, C. C. 32 Heinz, G. A. 89, 98 Ett l, C. 79 Gordan, S. 87 Heinzel, S. 34 Evaristo, C. 74 Gramberg, T. 64 Heissmeyer, V. 34 Eyerich, S. 40, 49 Granucci, F. 46 Held, T. 57 Gresch, O. 52 Helm, O. 92 F Grimbacher, B. 49, 61, 62, 89 Henneberg, S. 36 Faas, M. 60 Groett rup, M. 25, 56, 57 Herold, M. 41, 79 Falk, C. 27, 46, 70, 72, 99 90, 94 Herppich, S. 96 Fati ma, N. 60 Grosche, L. 63 Herrmann, T. 66 Feist, M. 58 Groß, O. 47 Herse, F. 80 Felber, F. 49 Grote-Gálvez, R. I. 99 Hess, L. 88 Ferrick, D. A. 40 Gruppi, A. 14, 38, 87 Heuser, C. 76 Fest, S. 91 Grusdat, M. 98 Heyde, S. 56, 65 Feuerer, M. 46, 69 Güler, A. 90 Heyner, M. 42, 68 Fichtner, A. 66 Günther, P. 84 Hiepe, F. 79, 81 Filippis, C. 36 Hieronymus, T. 84 Fiocca Vernengo, F. 87 H Hierweger, A. M. 36 Fischer, F. 24, 90 Haack, S. 70 Hildebrand, D. 76 Fischer, F. 67 Haas, E. A. 65 Hilpert, C. 83 Fischer, R. 80 Hackel, A. M. 42 Hobeika, E. 78, 79 Flicker, S. 94 Haeberle, S. 60 Hoﬀ mann, M. 74, 81 Fliegauf, M. 61, 62 Hagl, B. 89 Hoﬀ mann, P. 50, 75, 96 Floess, S. 37, 70, 96 Hahlbrock, J. 56 Hojyo, S. 70, 71 Förster, I. 23, 66 Hahn, A. M. 70 Hölscher, C. 82 Förster, R. 23, 64 Halder, L. D. 39 Homberg, T. 80 Francisco, S. 90 Haller, D. 53 Hornung, V. 35 114 I�� C��, I�� S�� P�� A�� A��

Horst, A. K. 37, 60 Kaschubowski, K. E. 90 Krikki, I. 70 Hose, M. 70 Kaspers, B. 92 Krljanac, B. 63, 80, 96 Hosmalin, A. 40 Katsoulis-Dimitriou, K. 70 Krueger, A. 69, 78 Hoyer, B. 15, 31 Kaufmann, S. 44 Krug, A. B. 23 Huber, J. 84 Kehrmann, J. 66 Kruglov, A. 31 Huber, M. 48, 97 Keller, B. 26, 78 Kruse, S. 74 Huber, S. 36, 66, 96, 98 Keller, C. 50 Kube, D. 58, 74 Hühn, J. 22, 70, 96 Keppler, S. 26 Kühnel, I. 90 Hübler, M. 28 Kerstein, A. 71 Kumashie, K. 99 Keye, J. 66, 98 Kums, J. 41, 61 I Killy, B. 65 Kunze-Schumacher, H. 69 Ijspeert, H. 15 Kindermann, M. 67, 68 Kurts, C. 25, 63, 71, 76, 99 Ince, L. 68 King, C. 48 Kurz, S. 64 Ipsen Escobedo, A. 75 Kirschfi nk, M. 82 Kurzhals, S. 83 Irmscher, S. 82 Kirschnek, S. 79, 87 Kzhyshkowska, J. 80, 91 Kläsener, K. 58 J Klein, F. 20 L Jäck, H.-M. 18, 52, 57, 58 Klein, S. 89 Lacher, S. 29 Jahreis, S. 69 Klemm, P. 88 Lagler, J. 93 Janik, F. 18 Klinge, S. 64, 97 Lai, X. 84 Jank, L. 95 Klink, L. 66, 85 Lambrecht, B. 47 Janßen, O. 41, 98 Knipfer, L. 67, 68 Lang, R. 46, 65, 66, 85, 89 Jantsch, J. 47, 64, 85 Knippertz, I. 83, 96 Langeneckert, A. 85, 88 Javed, S. 91 Knolle, P. A. 48, 63, 64, 67 Langer Jacobus, T. 88 Jellusova, J. 47 86, 99 Lapuente, D. 32 Jensen-Jarolim, E. 47 Knopf, J. 59 Laumonnier, Y. 39, 82 Jeske, S. S. 73 Koch, C. 63, 96 Lazaridou, M. F. 91 Jiménez, M. 93 Koch-Nolte, F. 71, 79, 90 Ledo, A. 76 Jirmo, A. C. 94 91, 99 Lee, K.-H. 97 John, V. 85 Kohl, L. 85 Legewie, L. 67, 87 Jordan, S. 31 Köhl, J. 39, 82 Lehmann, C. H. K. 32, 57 Jung, S. 48 Kolesova, O. 56 Lett au, M. 98 Just, S. 70 Köllisch, G. 49 Liang, J. 70 Jux, B. 90 Komorowski, L. 51 Liedtke, K. 70 König, C. 59, 70 Linker, R. 31 K Kopf, M. 23 Loewendorf, A. 27 Kabelitz, D. 42, 97 Korn, M. 60 Loff redo-Verde, E. 86 Kälble, F. 72 Korthals, M. 41 Lohoff , M. 18, 19, 22, 52, 73 Kalden, J. 52, 53 Koschel, J. 70 97, 98 Kalfopoulou, E. 65 Kosinska, A. 32 Loos, P. 94 Kalinke, U. 15 Kouakanou, L. 97 Lorenzetti , R. 57 Kallert, S. 64 Kovacs, B. 39 Loschinski, R. 70 Kallies, A. 34 Koxholt, I. 52 Lübke, M. 63 Kallin, N. 48 Krebs, F. 74 Lucas, M. 27 Kalsoom, K. 61 Kreckel, J. 89 Lucas, S. 67, 87 Kaminski, L. 71 Kretschmann, S. 25, 56 Lücke, K. 64 Kammerl, I. 57 Kretschmer, L. 72 Ludwig-Portugall, I. 71 Kamradt, T. 53, 90 Kreutz, M. 17, 47, 74, 75 Lueckel, C. 48 Karsten, C. 82 Krieg, C. 28 Lühr, J. J. 25 Karunakaran, M. M. 66 Kriegel, M. 31 Luján, H. D. 14 115 I�� C��, I�� S�� P�� A�� A��

P Lundtoft , C. 87 Monteiro, J. 76 Pabst, O. 30 Lunemann, S. 85, 88 Morbach, H. 38, 62 Paduch, K. 85, 86 Lutz, M. 23, 84, 85 Mossel, M. 80 Pantsulaia, I. 91 Lutz, M. B. 97 Motran, C. 14 Papantonopoulou, O. 74 Luu, M. 66 Mott as, I. 73 Parzeres da Costa, C. 65 Lyszkiewicz, M. 26, 69, 78 Mrotzek, S. 57 Pasti lle, E. 43, 60, 66 Mulas, F. 84 Patt u, V. 99 M Müller, A. J. 56, 65 Paulsen, F. 18 Mackensen, A. 22, 56, 64 Müller, D. N. 31 Pausder, A. 89 68, 70, 74, 83, 96 Müller, F. 75, 90 Pawelka, K. 30 MacKerracher, A. 94 Müller, S. 18 Pawlik, A. 90 Mah, M. M. 90 Mursell, M. 70, 71 Pennavaria, S. 29 Mak, T. W. 20 Muscate, F. 70 Peters, C. 24, 97 Manger, B. 31 Petschenka, J. 25 Manske, K. 86 N Petzinna, S. 95 Manz, R. A. 34 Namislo, A. 90 Pezoldt, J. 50 Marischen, L. 68 Nelke, J. 61 Pfeff er, K. D. 46 Marolda, A. 63 Neubert, P. 57, 64 Pfeifl e, R. 81 Marschall, A. L. J. 58 Neudörfl , C. 72 Pfützner, W. 16 Marsh-Wakefi eld, F. 96 Neumann, K. 56, 96 Pickl, W. F. 47 Marti n, S. 47 Neurath, M. F. 23, 67 Pieper, K. 58 Mashreghi, M.-F. 69, 89, 98 Niehues, T. 15 Plaza Sirvent, C. 50 Matt ner, J. 38, 76 Niemz, J. 96 Pokoyski, C. 72 Maul, J. 69 Nikolouli, E. 96 Popp, V. 37 Maul-Pavicic, A. 80 Nimmerjahn, F. 32, 58, 59, 60 Pracht, K. 38, 58 Mayer, E. 92 75, 83, 87 Prinz, I. 14, 69, 94, 98 Mayer, S. 86 Nishanth, G. 36 Punti gam, L. K. 73 Meiners, J. 85 Nitschke, L. 34, 57, 59, 60, 75 Pylaeva, E. 64, 74 Meinl, E. 95 Noll, J. 30 Meintker, L. 64 Nowak, A. 96 Q Meinzinger, J. 58 Ntalli, A. 37 Qu, B. 67, 69 Melchers, G. F. 18 Nurjadi, D. 85 Quandt, D. 17, 75 Mellado, G. 91 Quast, T. 85, 99 Menevse, A. N. 51, 95 O Quintar, A. 68 Merches, K. 87 Obermeyer, S. 86 Qureischi, M. 27 Meston, D. 97 Odak, I. 72 Mey, F. 82 Ohnmacht, C. 16 R Meyer, N. 42 Okwor, I. 63 Raache, R. 81, 95 Mezioug, D. 61 Olaru, F. 84 Radbruch, A. 34, 58, 69, 70, 71 Michalski, J. 83, 96 Omata, Y. 67, 87 79, 81, 89, 98 Michel, J. 80 Opitz, B. 46 Raft ery, M. 85 Mielenz, D. 26, 57, 58 Orinska, Z. 79 Rajewsky, K. 33 Minguet, S. 38 Orlik, C. 70, 94 Ramirez, N. 89 Möbs, C. 16 Ostrand-Rosenberg, S. 22 Rammensee, H.-G. 42, 56 Modak, M. 37 Ostrop, J. 60, 89 Ramming, A. 38 Mohamed, M. 66 Ott müller, K. 72 Randow, F. 46 Mohamed Raffi , F. A. 89 Ott o, L. 71 Rapp, A. 39 Mohanta, S. 94 Rausch, S. 87 Moin, S. 60, 69 Ravichandran, G. 31, 81 Mokada Gopal, L. 57 Reichardt, H. 49 116 I�� C��, I�� S�� P�� A�� A��

Reiling, N. 81, 86 Sautt er, C. 93 Schulz, C. 83 Reimer, D. 57, 58 Sawitzki, B. 96, 97 Schulz, S. 57, 58 Reimer, K. C. 59 Scalerandi, M. V. 68 Schulze, A. 36 Reimers, D. 60, 99 Schäfer, J. 86 Schulze, J. 97 Reinhardt, A. 20, 98 Schaff ert, A. 58 Schumacher, A. 84 Reisser, T. 72 Schaft , N. 24, 69, 75, 76, 84 Schupp, J. 73 Reithofer, M. 49 Schamel, W. 34 Schütz, C. 28, 74, 91 Reitz, M. 86 Schatz, V. 64, 85 Schwab, L. 68 Renner, E. D. 23 Scheff old, A. 47, 81, 96 Schwartz, C. 30 Renner, K. 17, 74, 75 Schett , G. 53, 59, 67, 80, 81 Schwinzer, R. 27, 72 Renz, H. 47 87, 89 Scognamiglio, P. 98 Reynaud, C.-A. 33 Scheu, S. 14, 23, 61, 73, 83 Seifried, H. 57 Richardson, J. R. 83 Scheurer, J. 27, 72 Seliger, B. 17, 24, 75, 91 Richter, A. 28, 74 Schick, J. 66 Serfl ing, E. 71 Richter, K. 48, 65 Schild, H. 22, 56 Serr, I. 80, 97 Richter, L. 73 Schiller, B. 60, 67, 81 Setz, C. 78 Rieck, M. 99 Schleicher, U. 42, 58, 85, 86 Shaneh Sazzadeh, S. 67 Riegel, C. 19 87, 89, 97 Silva-Vilches, C. 84 Riemer, A. B. 42, 74 Schliehe, C. 25 Simjee, S. 58 Riethmüller, G. 22 Schlitzer, A. 43, 74, 83, 84 Singer, K. 17, 75 Rip, J. 26 Schlöder, J. 99 Sinha, S. 98 Rissiek, B. 95, 99 Schloer, S. 65 Siracusa, F. 69 Ritt er, K. 32 Schlosser, J. 44 Sitnik, K. 48 Ritt er, U. 32, 85, 86 Schlößer, S. 86 Smallwood, T. 59 Rivero, V. E. 14, 15, 46 Schmalzl, A. 65 Smulski, C. R. 26, 62 Rizzi, M. 26, 57, 58, 72 Schmidt, C. 39, 82 Solbach, W. 44 Rodewald, H.-R. 46 Schmidt, F. 66, 98 Sonner, J. K. 67 Roediger, B. 43 Schmidt, M. 79, 94 Sopper, S. 61 Rohde, F. 92 Schmidt, R. E. 35, 81 Soulat, D. 87 Rohr, J. 71 Schmidt, S. 92 Sparwasser, T. 14, 15, 47, 74 Rokvic, L. 57 Schmidt, S. 90 Sreekantapuram, S. 92 Rollenske, T. 24 Schmidt-Weber, C. 16 Staege, M. 90 Rolot, M. 88 Schmitt , M. 38 Staniek, J. 57 Rony, S. A. 92 Schmitz, I. 34, 68, 70, 89, 95 Stark, R. 71 Rössig, C. 22 Schmueck-Henneresse, M. 25 Staudenraus, D. 95, 98 Royzman, D. 59 Schnare, M. 86 Steff ens, N. 87 Rückert, M. 73, 76 Schneider, B. 63 Steinecke, C. 79 Ruland, J. 50 Schneider, M. 88 Steinhoff , U. 66, 67 Ryabov, V. 80 Schober, K. 19 Steinkasserer, A. 37, 59, 63 Schoedsack, M. 30 70, 83, 96 S Scholz, J. 79 Steinle, A. 30, 90 Saalmüller, A. 44, 92 Schraml, B. 43 Steinmetz, T. 57, 58 Sadjia, l. 94 Schraven, B. 29 Strasser, A. 46, 79 Sakaguchi, S. 46 Schröder, C. 62 Strasser, E. 56 Salinas Tejedor, L. 95 Schröder-Heurich, B. 82 Strobl, C. 42, 96 Salvermoser, J. 84 Schroeder Castagno, M. E. 80 Strowig, T. 59, 67 Samstag, Y. 47, 67, 70, 94 Schruefer, S. 85 Sullivan, N. 44 Sánchez Gómez, I. 78 Schuh, W. 14, 26, 57 Summerfi eld, A. 44, 76, 92, 93 Sandrock, I. 98 Schuler, G. 22, 75, 83, 84 Symowski, C. 63 Sarkander, J. 70, 71 Schultze, J. L. 23, 89 Szumilas, N. 59 117 I�� C��, I�� S�� P�� A�� A��

T W Z Talker, S. 93 Wabnitz, G. 41, 70 Zaiss, M. 30, 67, 87 Tauber, P. 99 Wagner, J. 68 Zakeri, A. 94 Tesch, S. 81 Waisman, A. 36, 60, 95 Zehn, D. 22, 40 Thuma, N. 64 Wallrapp, A. 30 Zhao, R. 67, 69 Tiegs, G. 56, 59, 60, 67, 81, 96 Wang, X. 51, 84 Zhong, B. 65 Tiphany, C. 75 Wardemann, H. 32 Ziegler, A. 32 Tischner, D. 95 Warren, S. 52 Zielinski, C. 15, 37 Tkachev, A. 94 Wasén, C. 37 Zimmer, N. 96 Tognarelli, S. 68 Wasmuth, S. 81 Zinser, E. 37, 59, 83, 96 Tokoyoda, K. 38, 69, 70, 71 Watzl, C. 35, 42, 88, 95 Zipfel, P. F. 39, 82 Tolksdorf, F. 90, 99 Wehner, R. 73 Zou, M. 19 Tolosa, E. 29 Wehr, C. 58, 72 Torcellan, T. 42 Weise, A. 57 Tounsi, N. 61 Weiß, A. 79 Treptow, S. 58 Weiß, R. 89 Troilo, A. 58 Weißenborn, C. 91 Tumes, D. 32 Weltzsch, J. P. 37 Tybulewicz, V. 34 Weppner, G. 60 Wichert, A. 63 U Wieland, A. 78 Überla, K. 32, 75 Wienands, J. 34, 79 Uckert, W. 91 Wiese, F. 69 Uebele, J. 65 Wilantri, S. 81 Ufermann, C.-M. 87 Wild, A. 59 Ulas, T. 74, 83, 88 Wildner, G. 37 Ullrich, E. 35, 68, 73, 83 Wildschütz, L. 59 Uluçkan, Ö. 30 Wilharm, A. 29 Urbanczyk, S. 57 Winter, S. 29, 69 Uri, A. 73 Wirtz, S. 28, 30, 65, 67, 68, 87 Usuwanthim, K. 68 Wischhusen, J. 17, 18, 24 Utzschneider, D. T. 99 Wixler, V. 37 Wlodarski, M. 15 V Wolkers, M. 19, 71 Valencia, H. 91 Wolz, O.-O. 78 Valenta, R. 16 Wu, H. 66, 74 van Ham, M. 70 van Sorge, N. 30 X van Zandbergen, G. 24, 86, 91 Xia, Y. 49 Vanshylla, K. 79 Xu, L. 97, 99 Vatzia, E. 44, 92 Vierbuchen, T. 65 Y isekruna, A. 37, 66, 67 Yamasaki, S. 35, 86 Vivas, W. 83 Yang, J. 38, 58 Vogel, K. 69 Yang, J. 50 Vöhringer, D. 23, 57, 58, 59 Yokoyama, W. M. 46 63, 64, 67, 68, 80, 83, 85, 96 Yu, J. 97 Voll, R. E. 36 Yu, P. 79 Volmari, A. 48, 64 Yu, Z. 61 Volz, T. 16 118 C��

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In 2017, we celebrate BioLegend’s 15th anniversary. Since our founding in 2002, we have been recognized as providing high Antibody Pricing No. 1 quality reagents at a superior value. As BioLegend has grown, we’ve Antibody Speci city Top 2 implemented production innovations for greater e ciency and economies Antibody Reproducibility Top 2 of scale. The resulting cost-savings are passed on to our customers. For the years to come, we promise quality without compromise. Technical Support Top 2

Learn more about our anniversary promotions and giveaways at: *Biocompare Antibody Report, 2015 biolegend.com/15th_anniversary BioLegend is ISO 9001:2008 and ISO 13485:2003 Certi ed

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