The Effect of Morphological Variations at the Human Ankle and Hip Joints on Their
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The Effect of Morphological Variations at the Human Ankle and Hip Joints on their Biomechanical Function A Thesis Submitted to the Faculty of Drexel University by Ramya Namani in partial fulfillment of the requirements for the degree of Doctor of Philosophy September 2015 i © Copyright 2015 Ramya Namani. All Rights Reserved. ii Acknowledgments I would like to express my gratitude to my advisor Dr. Sorin Siegler for his tremendous support throughout my PhD program. His knowledge and passion for Biomechanics motivated me every day to develop my career in Biomechanics. He is one of the kindest and humble persons I have known. I would like to thank other committee members Dr. Jack Zhou, Dr. Sriram Balasubramanian, Dr. Fred Allen and Dr. John Lacontora for their time and their valuable feedback in writing my thesis. I would like to thank Dr. Javad Parvizi from Rothman institute for his guidance and collaboration with the hip project. My sincere gratitude to my academic advisor, Dr. Alan Lau for his tremendous support and pushing me to finish my PhD on time. He is one of the most knowledgeable as well as kind persons I have met at Drexel. I would like to thank International Society of Biomechanics for their support in awarding me a dissertation grant and a travel grant. The dissertation grant supported me to pursue the project and the travel grant gave me an opportunity to attend ISB conference and present my work and get feedback from some experts in Biomechanics field. Lastly, I would thank all the staff of Drexel University for helping me in completing this program smoothly. iii TABLE OF CONTENTS List of Tables .................................................................................................................... vii List of Figures .................................................................................................................. viii Abstract ............................................................................................................................. xv Chapter 1: Introduction ....................................................................................................... 1 Main Goal ........................................................................................................................ 1 Specific Aims .................................................................................................................. 2 Chapter 2: Background ....................................................................................................... 3 Variations in Morphology ............................................................................................... 3 Variations in Mechanics .................................................................................................. 3 Morphology-Mechanics Relationship ............................................................................. 3 Ankle Joint ...................................................................................................................... 4 Variations in Morphology of Bones in Ankle Joint ........................................................ 7 Variations in Orientation of Ligaments ......................................................................... 22 Variations in Mechanics ................................................................................................ 24 Terminology of the Motion ....................................................................................... 24 Ankle Joint Coordinate System ................................................................................. 27 Hip Joint Morphology ................................................................................................... 31 Variations in Morphology of Hip Joint- Effect on Joint function ................................. 33 iv Femoroacetabular Impingement (FAI) ...................................................................... 33 Hip Joint Mechanics .................................................................................................. 38 Hip Morphological Parameters .................................................................................. 40 Chapter 3: Methodology ................................................................................................... 46 Methodology part 1: Model Development ........................................................................ 46 Ankle Joint .................................................................................................................... 46 Step 1: Image Processing ........................................................................................... 46 Step 2: Post Processing .............................................................................................. 48 Step 3: Rigid Body Dynamic Model ......................................................................... 48 Hip Joint ....................................................................................................................... 54 Step 1: Image Processing ........................................................................................... 54 Step 2: Post Processing .............................................................................................. 55 Step 3: Rigid Body Dynamic Model ......................................................................... 57 Zone Method to Quantify Interference ...................................................................... 59 Methodology part 2: Effect of Change in Morphology on Joint Mechanical Behavior ... 62 Ankle Joint .................................................................................................................... 63 Step 1: Selecting and Measuring the Morphological Parameters: ............................. 63 Step 2: Changing Morphology of Bone and Ligament Insertion Sites and Comparing the Mechanical Behavior ........................................................................................... 65 Measuring Mechanical Properties ............................................................................. 72 v Statistical Analysis .................................................................................................... 74 Hip Joint ........................................................................................................................ 75 Step 1: Selecting and Measuring Morphological Parameters .................................... 75 Step 2: Changing Morphology of Normal Hips and Comparing the Joint Mechanical Behavior..................................................................................................................... 76 Chapter 4: Results ............................................................................................................. 85 Model Development.......................................................................................................... 85 Ankle Joint .................................................................................................................... 85 Step 1: Image Processing ........................................................................................... 85 Step 2: Post Processing .............................................................................................. 85 Step 3: Rigid Body Dynamic Model ......................................................................... 85 Model Development.......................................................................................................... 88 Hip Joint ........................................................................................................................ 88 Step 1: Image Processing ........................................................................................... 88 Step 2: Post Processing .............................................................................................. 88 Step3: Rigid Body Dynamic Model of Hip Joint ...................................................... 88 Effect of Change in Morphology on Joint Mechanical Behavior ..................................... 89 Ankle Joint .................................................................................................................... 89 Step 1: Selecting and Measuring Morphological parameters .................................... 89 Step 2: Changing the Morphological Parameters ...................................................... 90 vi Effect of Change in Morphology of Sustentaculum Tali on Joint Mechanical Behavior................................................................................................................... 102 Hip Joint ...................................................................................................................... 114 Step 1: Comparing Morphological Parameters between FAI and Normal hips ...... 114 Comparing Interference Pattern between FAI and Normal ..................................... 117 Step 2: Changing the Morphological Parameters .................................................... 123 Chapter 5: Discussion ..................................................................................................... 134 Model development ........................................................................................................ 134 Effect of Change is Morphology on Joint Mechanical Behavior ................................... 135 Chapter 6: Summary and Conclusions ............................................................................ 139 Significance ................................................................................................................