July 23-27, 2018 Asia-Pacific  NEURO-ONCOLOGY FAIRMONT ORCHID HOTEL CME CONFERENCE WAIMEA, HAWAII

Join us for our inaugural 5-day comprehensive educational conference on neuro-oncology. Presenters from around the world will share their expertise on this ever evolving multi-disciplinary field.

Register by June 4, 2018 to receive $100 off your registration fee!

COURSE DIRECTOR Tracy Batchelor, M.D. Massachusetts General Hospital Cancer Center

COURSE CO-DIRECTORS Nino Chiocca, M.D., Ph.D. Nancy Tarbell, M.D. Brigham and Women’s Hospital Harvard Medical School

Jay Loeffler, M.D. Patrick Wen, M.D. Massachusetts General Hospital Dana-Farber Cancer Institute

www.hms-apno.com General Information

Overview Neuro-oncology is a rapidly evolving multi-disciplinary field, which involves the medical, surgical and radiation management of adult and pediatric patients with primary and metastatic brain and spinal cord tumors. In addition, modern molecular neuropathology and neuroradiology concepts are essential for accurate diagnosis and classification. This five-day CME course is designed to provide an international audience with a comprehensive review of the diagnosis and management of adult and pediatric patients with primary and metastatic brain and spinal cord tumors and neurologic complications of cancer. Target Audience This course is targeted to health care specialists involved in the care of adult and pediatric neuro-oncology patients (oncologists, radiation oncologists, neurosurgeons, neurologists, neuroradiologists, and Conference Site neuropathologists). FAIRMONT ORCHID HOTEL WAIMEA, HAWAII Learning Objectives Upon completion of this activity, participants will be able to: • Evaluate, diagnose and treat adult and pediatric patients with primary and metastatic central nervous system tumors Register Online • Appreciate the role of biomarkers in the diagnosis and treatment of brain and spinal cord tumors www.hms-apno.com • Recognize and address neurological complications associated with cancer and new cancer therapies • Discuss the role of palliative and supportive care in neuro-oncology Cancellation Policy Registration Fees Refunds, less an administrative fee of $75, will be issued for all cancellations Physician (MD/DO) $675.00 received at least two weeks prior to the Allied Health Professional/ Other $550.00 start of the course. No refund will be Industry $875.00 issued should cancellation occur less than two weeks prior. “No shows” are subject Early Registration Discount: Register by June 4, 2018 and to the full course fee. receive $100 off your registration fee. The participant registration fee includes all sessions, continental breakfasts, Welcome Reception on Monday, and Inquiries continuing education credit. Accompanying Guest - 12 and Over $100.00 BY PHONE: Accompanying guests may join conference participants during continental 1-617-384-8600 breakfasts and breaks (as part of the main conference) from Monday Monday - Friday, 9 am to 5 pm (ET) through Friday and the Welcome Reception on Monday. Registration by credit card (VISA, MasterCard or American Express) or check can BY EMAIL: be made through Harvard Medical School’s secure online registration system. [email protected] Registration by check (draft on a bank), please make payable to Harvard Medical School. Learners who choose to pay by check will be prompted to download an online form to send in with a payment. Telephone or fax registration is not accepted. Registration with cash payment is not permitted. Upon receipt of your paid registration, you will receive an email confirmation. Be sure to include an email address that you check frequently. Your email address is used for critical information including registration confirmation, evaluation and certificate. 2 www.hms-apno.com

Accreditation The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Harvard Medical School designates this live activity for a maximum of 27.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The Royal College of Physicians and Surgeons of Canada recognizes conferences and workshops held outside of Canada that are developed by a university, academy, hospital, specialty society or college as accredited group learning activities.

Through an agreement between the American Medical Association and the European Union of Medical Specialists, physicians may convert AMA PRA Category 1 Credits™ to an equivalent number of European CME Credits® (ECMECs®). Information on the process of converting AMA PRA Category 1 Credits™ to ECMECs® can be found at: www.eaccme.eu.

Disclosure Policy Harvard Medical School (HMS) adheres to all ACCME Accreditation Criteria and Policies. It is HMS’s policy that those who have influenced the content of a CME activity (e.g. planners, faculty, authors, reviewers and others) disclose all relevant financial relationships with commercial entities so that HMS may identify and resolve any conflicts of interest prior to the activity. These disclosures will be provided in the activity materials along with disclosure of any commercial support received for the activity. Additionally, faculty members have been instructed to disclose any limitations of data and unlabeled or investigational uses of products during their presentations.

Disclaimer CME activities accredited by Harvard Medical School are offered solely for educational purposes and do not constitute any form of certification of competency. Practitioners should always consult additional sources of information and exercise their best professional judgment before making clinical decisions of any kind.

3 Schedule

July 22, 2018

Sunday

3:00-5:00 pm Registration Open

July 23, 2018 Monday: Gliomas

7:00 am Registration/Breakfast

7:20 am Welcome

7:30 am Brain Tumor Biology 101: Genomics (Priscilla Brastianos, M.D.)

7:45 am Brain Tumor Epidemiology (Kyle Walsh, Ph.D.)

8:15 am Revised WHO Classification for Gliomas (Andreas von Diemling, M.D.)

8:45 am Advances in the Imaging of Gliomas (Leland Hu, M.D.)

9:15 am Surgical Advances in Glioma Management (Nino Chiocca, M.D., Ph.D.)

9:45 am Break

10:00 am Radiation Advances in the Treatment of Glioblastoma (Erik Sulman, M.D., Ph.D.) for Newly Diagnosed Glioblastoma — Does MGMT Methylation 10:30 am Status Matter? (Wolfgang Wick, M.D.) 10:45 am Treatment of Recurrent Glioblastoma (Susan Chang, M.D.)

11:15 am Management of Glioblastoma in Elderly Patients (Sith Sathornsumetee, M.D.) Contemporary Issues in Neuro-Oncology: Role of Tumor Treatment Fields 11:45 am (Michael Weller, M.D.) 12:00 pm Adjourn

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July 24, 2018

Tuesday: Gliomas

7:00 am Breakfast

7:25 am Welcome

7:30 am Brain Tumor Biology 101: Metabolomics (Daniel Cahill, M.D., Ph.D.)

7:45 am Experimental Therapies for Glioblastoma — Surgical (Bob Carter, M.D., Ph.D.)

8:15 am Experimental Therapies for Glioblastoma — Medical (Frank Winkler, M.D.)

8:45 am Anaplastic Gliomas (Patrick Wen, M.D.)

9:15 am Low-Grade Gliomas (Andrew Chi, M.D., Ph.D.)

9:45 am Break

10:00 am Targeted Therapy for Gliomas (Isabel Arrillaga-Romany, M.D., Ph.D.)

10:30 am Immunotherapy for Gliomas (Michael Platten, M.D.)

11:00 am Spinal Cord Gliomas (Ganesh Shankar, M.D., Ph.D.)

11:30 am Ependymomas (Rakesh Jalali, M.D.) Contemporary Issues in Neuro-Oncology: PCV versus Temozolomide 11:45 am (Wolfgang Wick, M.D.) 12:00 pm Adjourn

1:30 – 4:30 pm Symposium 1: International Tumor Board — Glioma

July 25, 2018

Wednesday: Non-Glial Tumors and Supportive Neuro-Oncology

7:00 am Breakfast

7:25 am Welcome

7:30 am Brain Tumor Biology 101: Tumor Tubules (Frank Winkler, M.D.)

7:45 am Pituitary Tumors (Jay Loeffler, M.D.)

8:15 am Meningiomas (Priscilla Brastianos, M.D.)

5 Schedule

July 25, 2018

8:45 am Craniopharyngiomas (Bob Carter, M.D., Ph.D.)

9:00 am Primary CNS Lymphoma (Tracy Batchelor, M.D.)

9:30 am Break

9:45 am CNS Histiocytoses (Lakshmi Nayak, M.D.)

10:15 am Neurocognitive Issues in Brain Tumor Patients (Michael Parsons, Ph.D.)

10:45 am Supportive Care for Brain Tumor Patients (Sith Sathornsumetee, M.D.)

11:15 am Palliative Care for Brain Tumor Patients (Deborah Forst, M.D.) Contemporary Issues in Neuro-Oncology: Bevacizumab for Non-Glial Tumors 11:45 am (Scott Plotkin, M.D.) 12:00 pm Adjourn

July 26, 2018

Thursday: Nervous System Metastases and Neurological Complications of Cancer

7:00 am Breakfast

7:25 am Welcome

7:30 am Brain Tumor Biology 101: Immunology (Michael Platten, M.D.)

7:45 am CNS Metastases — Biology (Priscilla Brastianos, M.D.)

8:15 am Brain Metastases — Surgery and Radiation (Ian Dunn, M.D.; Jay Loeffler, M.D.)

8:45 am Brain Metastases — Medical and Experimental Therapies (Riccardo Soffietti, M.D.)

9:15 am Leptomeningeal Metastases (Adrienne Boire, M.D., Ph.D.)

9:45 am Break

10:00 am Metastatic Epidural Spinal Cord Compression (Shota Tanaka, M.D.)

10:30 am Metastases to Plexus and Peripheral Nerve (Eric Wong, M.D.)

10:45 am Paraneoplastic Neurological Syndromes (Jorg Dietrich, M.D., Ph.D.) continued

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July 26, 2018

11:15 am Neurological Complications of New Cancer Therapies (Eudocia Q. Lee, M.D., M.P.H.) Contemporary Issues in Neuro-Oncology: WBRT for Brain Metastases 11:45 am (Jay Loeffler, M.D.) 12:00 pm Adjourn

1:30 - 4:30 pm Symposium 2: International Tumor Board — Non-Glial Tumors

July 27, 2018

Friday: Pediatric Nervous System Tumors and Tumor Susceptibility Syndromes

7:00 am Breakfast

7:25 am Welcome Brain Tumor Biology 101: The Neuronal Tumor Microenvironment 7:30 am (Michelle Monje, M.D., Ph.D.) 7:45 am WHO Classification for Pediatric CNS Tumors (Andreas von Diemling, M.D.)

8:00 am Medulloblastoma (Stefan Pfister, M.D.)

8:30 am Pediatric Low-Grade Gliomas (Mark Kieran, M.D., Ph.D.)

9:00 am Pediatric High-Grade Gliomas/DIPG (Michelle Monje, M.D., Ph.D.)

9:30 am AT/RT and Other Rare Pediatric CNS Tumors (Susan Chi, M.D.)

9:45 am Break

10:00 am CNS Germ Cell Tumors (Nancy Tarbell, M.D.)

10:15 am Pineal Region and Embryonal Tumors (Nancy Tarbell, M.D.)

10:45 am Neurofibromatosis (Scott Plotkin, M.D.)

11:15 am Tuberous Sclerosis Complex (Daniel Cahill, M.D., Ph.D.)

11:45 am Von Hippel Lindau Syndrome (TBD) Contemporary Issues in Neuro-Oncology: Molecular Subsets of 12:15 pm Medulloblastoma (Mariella Filbin, M.D., Ph.D.) 12:30 pm Conference Adjourns

7 Hotel

Accommodations Additional Room Occupants The Conference is holding a block of rooms at the meeting Each extra person sharing a room will be charged an venue: Fairmont Orchid. ALL rooms in the block are additional $75 plus tax per night, beginning with the third Garden View Rooms at a rate of $269/night (+14.42% adult. There will no charge for children under the age of 18 taxes). The room block is from 7/22/18-7/27/18; however, years sharing the same room with their parents and utilizing the discounted rate will be available through 8/4/18, existing bedding. Maximum occupancy is 3 adults or 2 adults and 2 children per room. A $75.00 per rollaway fee applies. dependent upon room availability. To book your hotel This fee will be waived if guest is paying additional for the room, please use the following link: third and fourth adult. The maximum number of rollaways https://tinyurl.com/ybrmh8m4 per room or suite is 1. PLEASE NOTE: The room block will expire on Sunday, July 1, 2018. Accessible Room Requests: Requests for accessible rooms may be made at the time of Additional Charges And Fees: booking your room reservation. Descriptions of guest rooms are available on the hotel’s website here: There is an additional resort charge of $10.00 per room per night plus tax (4.166%) that is not included in the base room www.fairmont.com/orchid-hawaii/accommodations rate. The following amenities are included in this charge: or by calling the hotel’s Reservations Department:

• Unlimited basic internet access in guest rooms, 808-885-2000 meeting space, and resort public areas – wireless & wired Child Policy: Self-parking for one vehicle per room • Age 6 to 12 years of age: 50% off of regular published menu • Local, domestic long distance and 1-800 access calls prices (excludes In Room Dining, Brown’s Deli and Beach & Pool). from guest room 5 Years and Under: Meals and gratuity are complimentary based In-room bottled water, refreshed daily at turndown • on Children’s Menu when dining with an adult that is a registered • 24 hour access to the fitness center guest of the Hotel (excludes In Room Dining, Brown’s Deli and Beach • On-demand shuttle transportation within the & Pool). Mauna Lani Resort • Snorkel equipment rental (based on 2 sets per room, per day – resort use only). • Various cultural activities, including daily arts and crafts, cultural hikes, tide pool and snorkel instructions (subject to space availability) • 10% discount on published pricing for Fairmont Orchid Luau • Bottle of water in the room upon arrival • 45-minute photo shoot on the scenic grounds of the Fairmont Orchid with Pacific Dream Photography (subject to space availability). Does not apply to group photos.

FAIRMONT ORCHID HOTEL WAIMEA, HAWAII

8 Travel www.hms-apno.com

Airports

The two closest airports to The Fairmont Orchid are Kona International Airport (KOA) and Hilo International Airport (ITO). Kona International Airport (KOA) is located approximately 23 miles (45 minutes) from the hotel. Hilo International Airport (ITO) is located on the east side of the island approximately 77 miles (2 hours) from the hotel.

Airport Shuttle

The Fairmont Orchid does not provide complimentary shuttle service. The hotel’s Concierge Team will be happy to make an Air Taxi reservation for you (fees apply).

They can be reached at 1 (808) 887-7320 or via email: [email protected]

Taxi

Air Taxi is the recommended taxi service by the Fairmont Orchid. Approximate cost of a taxi ride between the Kona airport and the Fairmont is $76 + tax. Maximum number of guests per airport transport is five (5).

Parking

Parking is available at the hotel. Self parking is $17.00 per night and valet parking is $22.00 per night with unlimited access.

Off-property guests may have their parking pass validated for complimentary parking when a minimum purchase of $15.00 is made at any restaurant or store at the hotel.

9 Faculty

COURSE DIRECTOR Harvard Medical School Faculty Tracy Batchelor, M.D. Isabel Arrillaga-Romany, M.D., Ph.D., Massachusetts General Hospital Cancer Center Massachusetts General Hospital Cancer Tracy Batchelor, M.D., Massachusetts General Hospital Cancer Center Center Priscilla Brastianos, M.D., Massachusetts General Hospital Cancer Center Daniel Cahill, M.D., Ph.D., Massachusetts General Hospital Bob Carter, M.D., Ph.D., Massachusetts General Hospital COURSE CO-DIRECTORS Susan Chi, M.D., Dana-Farber Cancer Institute/Boston Children’s Hospital Nino Chiocca, M.D., Ph.D. Nino Chiocca, M.D., Ph.D., Brigham and Women’s Hospital Brigham and Women’s Hospital Jorg Dietrich, M.D., Ph.D., Massachusetts General Hospital Cancer Center Ian Dunn, M.D., Dana-Farber Cancer Institute/Brigham and Women’s Hospital Jay Loeffler, M.D. Mariella Filbin, M.D., Ph.D., Dana-Farber Cancer Institute/Boston Children’s Hospital Massachusetts General Hospital Deborah Forst, M.D., Massachusetts General Hospital Cancer Center Nancy Tarbell, M.D. Mark Kieran, M.D., Ph.D., Dana-Farber Cancer Institute/Boston Children’s Hospital Harvard Medical School Eudocia Q. Lee, M.D., M.P.H., Dana-Farber Cancer Institute/Brigham and Women’s Hospital Jay Loeffler, M.D., Massachusetts General Hospital Patrick Wen, M.D. Lakshmi Nayak, M.D., Dana-Farber Cancer Institute/Brigham and Women’s Hospital Dana-Farber Cancer Institute Michael Parsons, Ph.D., Massachusetts General Hospital Scott Plotkin, M.D., Massachusetts General Hospital Cancer Center Nancy Tarbell, M.D., Harvard Medical School Patrick Wen, M.D., Dana-Farber Cancer Institute/Brigham and Women’s Hospital Eric Wong, M.D., Beth Israel Deaconess Medical Center Invited Faculty Adrienne Boire, M.D., Ph.D., Memorial Sloan-Kettering Cancer Center Susan Chang, M.D., University of , Andrew Chi, M.D., Ph.D., NYU Langone Health Leland Hu, M.D., Mayo Clinic Rakesh Jalali, M.D., Tata Memorial Hospital, Mumbai Michelle Monje, M.D., Ph.D., Stanford Stefan Pfister, M.D., University of Heidelberg Michael Platten, M.D., University of Mannheim Sith Sathornsumetee, M.D., Siriraj Hospital, Bangkok Ganesh Shankar, M.D., Ph.D., Cleveland Clinic Riccardo Soffietti, M.D., University of Torino Erik Sulman, M.D., Ph.D., MD Anderson Cancer Center Shota Tanaka, M.D., University of Tokyo Andreas von Diemling, M.D., University of Heidelberg Kyle Walsh, Ph.D., Duke Cancer Institute Michael Weller, M.D., University of Zurich Wolfgang Wick, M.D., University of Heidelberg Frank Winkler, M.D., University of Heidelberg

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11 US Postage PAID Permit No. 1325 Department of Continuing Education Boston, MA P.O. Box 825 Boston, MA 02117-0825

July 23-27, 2018 Asia-Pacific  NEURO-ONCOLOGY FAIRMONT ORCHID HOTEL CME CONFERENCE WAIMEA, HAWAII www.hms-apno.com

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