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Selected Non-Moderated Posters International Journal of Impotence Research (2001) 13, Suppl 2, S17±S21 ß 2001 Nature Publishing Group All rights reserved 0955-9930/01 $15.00 www.nature.com/ijir Selected Non-moderated Posters 12 \' ASECOMY llEHA \'!ORAL EFFECTS IN MEN Authors: T. Bandel; R. Bauer; T. Sigerson. Bayer AG., Wuppertal, Germany Aragao, A J, Rodrigues A 0., Agostinho AG., Juliano, RV. \1arinc!li CM., Affiliation: Pharmacology, Bayer AG, Wuppertal, Germany Wroclavski, ER., Bozzo, I.S Objective: Evaluate the satisfaction degree and the behavioral effecb or vasectomy in the couple and in the man in matter VARDENAFIL'S IMPROVEMENT ON THE QUALITY OF ERECTIONS CAN BE Method There were selected 113 men submit1ed to sterilization by vasectomy, in DEMONSTRATED EARLY IN RIGfSCAN™ STUDIES. the period from January of 1996 to January of 1999, after approval of the Ethics ·commission of Family Planning Service from the Faculdadc de Medicina do ABC. A.JI the patients were called b~· Introduction and Objectives letter. telegram or phone calls, in a spontaneous way and not obligatory A di red questionnaire Vardenafil is a new highly selective PDE5 inhibitor that is being developed for treatment of \Vas used approaching the following: self-esteem aspects, orgasm corHroL sexual satisfaction, erectile dysfunction. ln two Phase Ila studies with patients with mild to moderate erectile complications, sexual habit and masturbation dysfunction, Rigiscan™ measurements of quality of erections were determined. The objective Results: 23,5% of the patients told that, the sexual relationship performance got of this retrospective analysis was to compare the effect ofvardcnafil on the strength of better and 71% didn't notice difference, 5,9% thought worst. Testicular pain was told in 17,6% erections that first occurred in a visual sexual stimulation period betw-een 20 min and 40 min and 5,9% pain at ejaculation. There were no regret and all would recommend it to a friend They after dosing didn't tell change of behavior with masturbation, premature ejaculation or libido in relation to pre­ vasectomy lime Materials and Methods · Conclusion: The vasectomy has high acceptance level and therefore lower regret 1n ffi·o different studies, patients with demonstrated erectile dysfunction for at least 6 months, level among selected couples. There is little alteration in the sexual behavior, however arrounds ¼ received either placebo, IO mg and 20 mg vardenafil or placebo 20 mg and 40 mg vardenafil of the males tell improvement in the pcrtOnnancc maybe because the decrease in the sexual act as a single oral dose in a randomized, double-blinded, three-way crossover design. Erectile anxiety and the partner's larger receptivity for the safety of the undcsircble pregnancy quality was determined with Rigiscan™ measurements. The primary outcome was the Key Words: Vasectomy, behavior duration of rigidity in excess of 60% for erections that were initiated by watching an erotic video tape starting 20 minutes after dosing for a 20 minute period. Patients repeated the video sessions two more times but, for this analysis, only erections that occurred in the first video session were analyzed. The treatment effect was evaluated statistically using ANOV A Results From each study, 21 patients were valid for efficacy evaluation. Erections generally started at or soon after the initiation of the video at 20 minutes after dosing. The mean duration of these erections, originating in the first video session, with greater than 60% rigidity at the base of the penis of patients on 40 mg was 26.0 minutes longer than those on placebo (p - 0.002). On 20 mg they were 16.3 minutes (p - 0.05) and 15.0 minutes (JF0.038) longer for the two separate studies. For the IO mg dose, there was no difference in activity from placebo at this early time point although significant differences were seen for this dose for the study as a whole. Significant differences were also seen for Tumescence Activity Units and Rigidity Activity Units for doses of20 and 40 mg. Conclusions This study demonstrates an early effect of vardenafil on improvement of erectile quality with both 20 mg (repeatable in two studies) and 40 mg doses. These results imply a fast onset of action for vardenafil, however specifically designed trials are needed to determine the earliest time of effect. Selected Non-moderated Posters S18 34 The use of Sodium Nitroprusside (SN) in the pharmacologically induced V ASOACTIVE DRUGS . INTRACAVERNOSAL(IC) AND ORAL(OR) erection - A prospective study in 25 patients ADMINISTRATION IN THE MALE ERECTILE DYSFUNCTION (MED) Walter J. Bestane, Mauricio C. Bestane, Ney Anderson Ramos Brito Cunha, P.R. ; ANDROCLOOCA; Rio de Janeiro; Brazil. Hospital Ana Costa- Santos, SP, Brasil Objective : Compare erectile responses between OR and IC administration . Material and Methods : Among 94 users of OR (29-82, average 55 years Purpose: The pharmacologically induced erection by self-injection therapy of age) and among 197 users of!C (33-83, average 59 years) we analiz.ed 63 is a world-wide accepted treatment for the erectile dysfunction. Tue patients whom, regardless of cause connections and MED degree , took tests Prostaglandin E1 (PGE1) or the combination of PGE1 and other drugs are 1he or make use of both alternatives in order to evaluate the sufficiency of their most widely-used vasoactive drugs for erection therapy. The Sodium erectile responses, in sight of the classical definition of the ISIR for MED Nitroprusside (SN), a strong vasoactive agent due to 1he Nitric Oxide (November, 7 , I 996 - "the consistent inability of a man to attain and maintain liberation, has been used with variable results in doses up to 940 mcg. The an erection of sufficient rigidity to permit satisfactory sexual intercourse").For purpose of this paper is to check the efficacy and safety of the Sodium OR , we used 50 mg of sildenafil citrate . For IC , we used a trimix solution with 1,25 µg ofPGE (alprostadil), 2 mg of PAP (cloridrate ofpapaverine) Nitroprusside in the pharmacologically induced erection. and 0,1 mg ofChlorpromazine(CLPZ). Patients and Methods; 25 patients with erectile dysfunction who had Results : Fifty-seven users (90%) of IC, and forty-five users (71.4%) of experienced intracavernous pharmacotherapy with a mixture of PGE1, OR considered the erection satisfactory. Six users of!C (10%)), and 18 users Papaverine and Clorpromazine for at least 3 months were evaluated. Under a of OR (28,6%) considered the erection unsatisfactory. signed consent, they were asked to use in at least two opportunities the self­ All 45 patients satisfied with OR administration state that the erectile injecton ofNitroprusside I mg. response with IC administration is superior , especially in the maintenance A total of22 patients completed the standardized protocol and Results: were aspect. In this same group , 55% (25) prefer IC administration and, in asked fill in a questionnaire comparing the response of the to drugs used. general, make use of OR administration at random meetings, trips, etc.; 45% Although erectile response to NS was statistically significant weaker (20) are completely satisfied with OR and do not use IC , for various reasons. compared to PGE1 mixture (p=0,007), 8 patients (36%) decided to continue Among the 18 pacients that do not respond to OR administration, 66,6% the use of it, IO patients returned to the PGE1 mixture injection and the other 4 (12) consider the erectile response satisfactory with IC , and 33,4% do not. patients were not quite sure about the best result. Painful erection was reported These 33,4% ( 6 patients), are the same patients in the 10% group (6 in 63 ), as mild in both treatments. Two out of eight patients who continued the use of equally not satisfied with IC administration . NS, reported that in spite of its weaker effect, the erection induced by this Conclusion : IC administration is still. a very effective method to best drug seemed to be more natural, occurring a new erection if they were evaluate / treat the MED . Mainly in patients who do not respond well to stimulated again. No side effects were reported by any patient. sildenafil. The method bas the potential to rescue a considerable number of Conclusions: Being a low cost, safety and effective drug that doesn't such patients , possibly preventing them from dropping the treatment and/or demand refrigeration to stock, the authors recommend it's use as an alternative delaying a penile implant . in 1he pharmacologically induced erection. KEY WORDS:erectile dysfunction ; intracavernosal administration ; vasoactive drugs . 56 SERIC FREE TESTOSTERONE AND TOTAL TESTSOTERONE TREATMENT OF THE PEYRONIE'S DISEASE WITH VERAPAMILO RELATED TO LOW LIBIDO IN MALE PATIENTS WITH SEXUAL DYSFUNCTION. INTRALESIONAL: Preliminary results Di Capua T., Szemat R.; Contreras Y., Marin™, Sucre T., Palomino C., Garcia Casabe A.; Roletto, L.; Cobreros, C.; Bechara, A.; Fredotovich, N. F., Pino J., Dieguez V., Garcia M., Jaimes JC., Palacios R., Valera V., Becerra S. Hospital “Dr. Domingo Luciani&#8221~, Caracas, Venezuela Hospital Durand- Division of Urology- Surgery's Department Objective: to determine the relationship between the low sexual desire and the IME- Instituto Medico Especializado - Buenos Aires- Argentina seric free testosterone vs. total testosterone levels in patients consulting for sexual dysfunction Objective: Evaluate the clinical modifications of the Peyronie's Disease at its Materials and Methods. out of 717 patients evaluated for male se:-..ual dysfunction initials
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