DOCSLIB.ORG

Medical Cannabis in Iowa

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Medical Cannabis in Iowa 4/9/2021 Kevin T. Schleich, PharmD, BCACP Clinical Pharmacy Specialist, Department of Family Medicine University of Iowa Hospitals and Clinics Objectives • Review historical context of medical cannabis and literature that addresses efficacy of cannabis for multiple medical conditions • Discuss safety concerns from both an acute and chronic use standpoint • Compare and contrast available formulations of medical cannabis in Iowa • Highlight the process by which patients in Iowa can receive medical cannabis United States' "Dealers” https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx 1 4/9/2021 Weed 101 • Marijuana contains numerous extractable substances – Steroidal components – Volatile compounds • 60 cannabinoids can be isolated – Delta-9-tetrahydrocannabinal (THC): main psychoactive cannabinoid – Cannabidiol (CBD): main non-psychoactive cannabinoid Brand Name Active Ingredient FDA-Indication DEA Schedule Epidiolex® Cannabidiol (plant derived extract) Seizures V Marinol®, Syndros® Dronabinol (Synthetic THC) III AIDS: loss of appetite Cancer: chemotherapy-induced n/v Cesamet® Nabilone (Synthetic THC-analog) II Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations. Weed 101 • Two main cannabinoid receptors throughout the human body – CB1: brain, spinal cord, some periphery – CB2: intestinal tract, peripheral organs, immune system • Neither CBD or THC directly agonize either the CB1 or CB2 receptor – THC a partial agonist of CB1 – CBD influences endogenous cannabinoids Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations.. http://sensipharma.com/ecs Weed 101 • CBD antagonizes the effects of THC at the CB1 receptor THC THC + CBD • CBD + THC CBD – Pain relief – Anti-spasmodic • CBD only – Epilepsy Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations. www.analyticalcannabis.com 2 4/9/2021 Iowa Qualifying Conditions • Cancer, AIDS/HIV, or any • Crohn’s disease/ulcerative colitis terminal illness if: – Severe/chronic pain • Chronic pain* – Nausea/severe vomiting – Cachexia or severe wasting • Severe autism, intractable with self-injurious/aggressive • Neuromuscular disorders: behavior (pediatric and adult)* – Multiple sclerosis (with severe/persistent muscle spasms) • Post-Traumatic Stress Disorder – Amyotrophic lateral sclerosis (PTSD)* (ALS; Lou Gehrig’s Disease) – Parkinson’s disease • Corticobasal degeneration* • Seizures (including those characteristic of epilepsy) * Update since original legislation https://idph.iowa.gov/omc/For-Patients-and-Caregivers Does the Stuff Work? www.google.com/images Efficacy Data • The National Academies of Sciences, Engineering, and Medicine (NASEM) – “The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research” – Comprehensive report highlighting the health effects of recreational/therapeutic cannabis use – Published in 2017 – Cannabis still DEA Schedule I substance • Limited research capability (federal funding) • 194 current trials on ClinicalTrials.gov http://www.nationalacademies.org/hmd/Reports/2017/health-effects-of-cannabis-and-cannabinoids.aspx 3 4/9/2021 Efficacy Data • Chronic Pain – “…there is substantial evidence that cannabis is an effective treatment for chronic pain in adults” – NASEM cites 5 systematic reviews (n=2454) • Low-quality evidence • 2 studies focused on fibromyalgia • Pain scores decreased by ~30% on average – Generally, higher THC content = greater pain relief – 49 active trials on ClinicalTrials.gov Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations. http://www.nationalacademies.org/hmd/Reports/2017/health-effects-of-cannabis-and-cannabinoids.aspx www.clinicaltrials.gov Efficacy Data Demonstrated ~# of Current Clinical Condition Efficacy Trials Chronic Pain 115 Cancer/HIV-Related Symptoms 176* Seizures 14 MS Spasticity Symptoms 29 Parkinson’s 6 Crohn’s/UC/IBD 8 Autism 1 PTSD 17 *Majority are associated with pain control Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations. http://www.nationalacademies.org/hmd/Reports/2017/health-effects-of-cannabis-and-cannabinoids.aspx www.google.com/images 4 4/9/2021 Short-Term Adverse Effects • Marijuana inhalation/ingestion Impaired motor coordination Short-term memory Paranoia/psychosis impairment Dry mouth Tachycardia Hypertension Nausea/ vomiting www.google.com/images N Engl J Med. 2014;371(9):879 Long-Term Adverse Effects Addiction* Altered brain • 9%: overall development* • 17%: begin as adolescent • 25-50%: daily user Worsening educational Cognitive outcomes* impairment* Diminished life Increased risk of satisfaction* chronic psychosis disordersΩ * = effect strongly Ω = in those with a associated with initial use predisposition to such in adolescence disorders “Pharmacy stuff… pharmacy stuff… pharmacy stuff… pharmacy stuff… pharmacy stuff” www.google.com/images 5 4/9/2021 Pharmacokinetics Sublingual Trans- Inhaled Oral /Buccal cutaneous Onset Seconds 5-15 min ? 60 min Time to Peak 30 min 4 hours ? 4-6 hours Duration 2-4 hours ? ? > 8 hours Absorption < inhaled 10-35% CBD> THC ~5% Bioavailability > oral • Distributes readily into well-vascularized organs (lung, heart, brain, liver) Distribution • Chronic use accumulates in adipose tissue • THC highly lipophilic crosses placenta; excreted into breast milk Metabolism THC CYP2C9, CYP3A4 Active CBD CYP2C19, CYP3A4 (by CYP enzymes) metabolite (2x as potent) Inactive metabolite Routeof Elimination Half-Life THC: 22 hours Excretion Feces: 70% (5% unchanged) CBD, occasional use: 24-31 hours Urine: 30% CBD, frequent use: 2-5 days Ku, Jennifer. (2018). Cannabis Can Do What? Pharmacological Considerations with Cannabinoids. Drug-Drug Interactions www.google.com/images What Effects Cannabis Increase Cannabinoid Decrease Cannabinoid Levels Levels • Grapefruit • Rifampin • Azole antifungals • Carbamazepine • Clarithromycin • St. John’s Wort • Amiodarone • Barbiturates • HIV Antivirals • Common offenders for drug-drug interactions when utilizing the CYP enzyme system • Current manufacturers recommend monitoring efficacy and safety if administering concurrently with above drugs • No preemptive dose adjustments necessary Ku, Jennifer. (2018). Cannabis Can Do What? Pharmacological Considerations with Cannabinoids. 6 4/9/2021 What Cannabis Effects Cannabis Induces Cannabis Inhibits CYP2C8, CYP2C9, CYP2C19, UGT1A9, Enzymes CYP1A2, CYP2B6 UGT2B7 Decreases efficacy of the following Increases efficacy of the following Effect drugs drugs Neuro/psych: • Citalopram Neuro/psych: • Diazepam • Duloxetine • Lamotrigine • Haloperidol • Lorazepam • Olanzapine Platelet inhibitors: Musculoskeletal/analgesia: • Clopidogrel • Cyclobenzaprine Drugs Musculoskeletal/analgesia: • Naproxen • NSAIDS • Tizanidine Lipid-lowering: Opioids: • Fibrates • Methadone Anti-hyperglycemic: Hormones: • Sulfonylureas • Estradiol Opioids: • Morphine Ku, Jennifer. (2018). Cannabis Can Do What? Pharmacological Considerations with Cannabinoids. www.google.com/images Products in Iowa 20:1 2:1 1:1 1:20 (CBD:THC) (CBD:THC) (CBD:THC) (CBD:THC) 5 mg:5 mg 0.25 mg:5 mg Capsule 600 mg:30 mg/cap 0.5 mg:10 mg 10 mg:10 mg 1 mg:20 mg 5 mg:0.25 mg/0.25 mL Tincture ~5 mg:5 mg/0.25 mL 0.25 mg:5 mg/0.25 mL 25 mg:2 mg/0.25 mL 17.5 mg:8.75 mg/0.5 tsp* 17.5 mg:8.75 mg/0.5 tspΩ Cream 3.75 mg:1.875 mg/pump* 3.75 mg:1.875 mg/pumpΩ Vaporizer 215 mg: 10 mg/inhalation pediatric formulation; * = no scent; Ω = rosemary extract scent • Rectal and vaginal suppositories allowable (not currently supplied) www.medpharmiowa.com/products www.google.com/images 7 4/9/2021 What’s In Recreational? Product Weight/Size THC (mg) Pretzels 0.18 oz (5 g) 3 Honey 1 tsp: 0.2 oz (7 g) 8 Cookie 0.56 oz (16g) 10 Gummy Bear 0.09 oz (2.5 g) 25 Green Tea 0.07 oz (1.9 g) 40 ChocolateBar 1.5 oz(43 g) 200 Brownie 3.5 oz (100 g) 250 www.latimes.com/projects/la-me-weed-101-1hc-calculator/ www.google.com/images Can Anyone Afford This? • Insurance does not cover – Cash and debit cards only form of payment accepted – Credit card not permitted due to “federal regulations” • Price of all products published on MedPharm website • Cost obviously varies widely based on dose utilized/product www.medpharmiowa.com/products www.google.com/images www.google.com/images 8 4/9/2021 Prescribing Review Amoxicillin 500 mg Take 2 caps 3 times daily x 10 days #60 0 refills www.google.com/images “Attesting” Review You have a condition Dr. XYZ My high school degree and 2- week training course leads me to believe your child needs this dose of cannabis. www.google.com/images Application/Registration • Patients submit a three-page application to the Iowa Department of Public Health (IDPH) to receive a medical cannabidiol registration card – Available online at IDPH website – $100 non-refundable application fee – $25 non-refundable reduced application fee for low-income – Electronic application now accepted (https://idph.iowa.gov/cbd) • Patient must be > 18 years of age – Caregiver can obtain card for those < 18 years of age 9 4/9/2021 Application/Registration • Provider Attestation Requirements (page 3) – Established patient-provider relationship with the patient – A primary care provider of the patient involved in the diagnosis and treatment of the debilitating medical condition – Confirmation that the patient suffers from a qualifying condition – Have counseled patient (including guided patient to IDPH website) about benefits/risks of medical cannabidiol – Agree to annually evaluate continuing need Dispensary Sites Sioux City Waterloo Windsor Heights **Davenport
Load more

Recommended publications
  • Religious Use of Marijuana Cases
    Summaries of Religious Use of Marijuana Cases Alabama regulate was conceivable, only that none had Rheuark v. State (1992) 601 So.2d 135 been proposed. Statutes prohibiting possession of marijuana and controlled substances did not violate freedom of California: religion rights of defendant claiming that he People v. Mullins (1975) 50 Cal. App 3d 61 worshipped plants as gods and used marijuana Facts: A deputy sheriff had gone to defendant's and psilocybin as religious practice. premises at night at the invitation of a man who Court compared Defendant’s argument to a past lived in a teepee on the property and who had told ruling on polygamy and quoting the cases the officer there were marijuana plants growing Reynolds v. United State 98 U.S. 145 and there. The officer took two plants as samples to Cleveland v. United States 329 U.S. 14 which in be tested and, three days later, went back to the sum says that morality is defined by statute and property with a search warrant. Defendant's Congress and not the individual’s perceptions of property is not enclosed or surrounded by a morality. Therefore because the possession of fence. From Ten Mile Creek Road there is a marijuana is unlawful, it doesn’t matter that the driveway that leads onto defendant's property. Defendant used it for religious use. There is no gate at the entrance to the property. At the entrance there is a sign reading “Universal Arizona: Life Church of Christ Light.” Defendant's wife People v. Hardesty (2009) 214 P.3d 1004 testified that on and prior to May 30, 1972, there FACTS: Hardesty was driving his van at night was a “no trespassing” sign at the entrance to the when an officer stopped him because one property; that a church known as “Universal Life headlight was out.
    [Show full text]
  • 130 E Aurora Ave Des Moines, IA 50313-3654 February 21, 2017 Bob Kressig 3523 Veralta Drive Cedar Falls, IA 50613 Dear Rep. Kres
    130 E Aurora Ave Des Moines, IA 50313-3654 February 21, 2017 Bob Kressig 3523 Veralta Drive Cedar Falls, IA 50613 Dear Rep. Kressig, I am writing regarding HSB 132, an Act relating to the medical cannabidiol Act, and making related modifications. HSB 132 would authorize the cultivation of cannabis in Iowa. The current federal penalty for cultivation of cannabis is life in prison and a $50 million fine. 21 U.S.C. § 841(b)(1)(A)(vii) (2017). HSB 132 does not say anything about federal law. Federal law requires that controlled substances be classified by administrative regulation. The current federal regulation of cannabis, as well as the Iowa classification, is schedule 1. A condition that must be met for a substance to be included in schedule 1 is that the substance must have no accepted medical use in treatment in the United States. HSB 132 says cannabis will be grown in Iowa to make medicine. There is a glaring inconsistency in accepting the medical use of cannabis in Iowa and leaving it classified as having none. You will be asking people to volunteer to for life in prison and a $50 million fine if you do not address this inconsistency. I would suggest amending the language to remove marijuana from Iowa schedule 1 and include a statement that Iowa is accepting the medical use of cannabis as defined by Congress in the federal controlled substances act. If I can be of any assistance, please let me know. Thank you! Sincerely, Carl Olsen 515-343-9933, [email protected] FEDERALISM If the state can establish medical use of a federally controlled substance, then how can a federal administrative agency interpret “accepted medical use in treatment in the United States” to exclude the accepted use of that substance in a state? Congress never defined the term “medical use.” See Alliance for Cannabis Therapeutics v.
    [Show full text]
  • Disclosure Objectives
    4/3/2019 Disclosure Kevin Schleich reports no actual or potential conflicts of interest associated with this presentation. www.google.com/images_cheech&chong Objectives • Review historical context of medical cannabis and literature that addresses efficacy of cannabis for multiple medical conditions • Discuss safety concerns from both an acute and chronic use standpoint • Compare and contrast available formulations of medical cannabis in Iowa • Highlight the process by which patients in Iowa can receive medical cannabis • Summarize the Department of Family Medicine’s (DFM) policy on medical cannabis 1 4/3/2019 Weed 101 • Marijuana contains numerous extractable substances – Steroidal components – Volatile compounds • 60 cannabinoids can be isolated – Delta‐9‐tetrahydrocannabinal (THC): main psychoactive cannabinoid • Dronabinol (Marinol®) – Cannabidiol (CBD): main non‐psychoactive cannabinoid • Agents non FDA‐approved in US, but currently investigational (Nabiximol®, Sativex®, Epidiolex®) Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations. Weed 101 • Two main cannabinoid receptors throughout the human body – CB1: brain, spinal cord, some periphery – CB2: intestinal tract, peripheral organs, immune system • Neither CBD or THC directly agonize either the CB1 or CB2 receptor – THC a partial agonist of CB1 – CBD influences endogenous cannabinoids Herman, Ronald A. (2018). Current Iowa Medical Cannabis Regulations.. http://sensipharma.com/ecs Weed 101 • CBD antagonizes the effects of THC at the CB1 receptor THC THC + CBD • CBD
    [Show full text]
  • The “Green Gold Rush”
    ACKRELL CAPITAL U.S. CANNABIS INVESTMENT REPORT 2016 The “Green Gold Rush” Contents n Foreword I Executive Summary II Legislative Landscape; Legal Issues for Investor Consideration III Cannabis 101 IV U.S. Cannabis Market Estimates Overview V Industry Segmentation VI Capital Markets for Cannabis Companies • Cannabis is federally illegal in the United States. However, as of VII Top 100 Private Cannabis Companies 2016 the date of this report, 39 states have legalized cannabis in some form for recreational or medicinal use. VIII Industry Risk Factors • The current consumer market for recreational and medicinal IX Glossary of Terms cannabis in the United States is estimated to be more than n Disclosures, Disclaimers, Sources and Use of This Report $40 billion, including both legal and illegal consumption. n Ackrell Capital Team Leaders • We believe that it is a question of when—not if—the federal prohibition on cannabis will end. In analyzing how the end of n Inside Back Cover: The Green Field 2016 prohibition may affect the cannabis industry, we have assumed that prohibition ends by 2020. However, even with federal pro- hibition, the cannabis industry today is large and dynamic. About Ackrell Capital • We estimate that the U.S. cannabis consumer market for legal- ized recreational and medicinal use was $4.4 billion in 2015 Founded in 2003, Ackrell Capital is a leading independent invest- and will grow to $9.5 billion in 2019. Once legalized federally, ment bank focused on emerging growth companies. Ackrell Capi- we estimate this market will grow to $37 billion within 5 years tal’s principals have completed more than 300 corporate finance and $50 billion within 10 years.
    [Show full text]
  • Marijuana and Actual Driving Performance
    0 US Department d lazportahon Nc3mkx r Trafft Safety Admkdshotlon DOT HS 808 078 November 1993 Final Report Marijuana and Actual Driving Performance This document is availalbe to the public from the Nftional Technical Information Service, Springfield, Virginia 22161 This publication is distributed by the U.S. Department of Transportation, National Highway Traffic Safety Adminis­ tration, in the interest of information exchange. The opinions, fmdings and conclusions expressed in this publication are those of the author(s) and not necessarily those of the Department of Transportation or the National Highway Traffic Safety Administration. The United States Government assumes no liability for its contents or use thereof. If trade or manufac­ turers' name or products are mentioned, it is because they are considered essential to the object of the publication and should not be construed as an endorsement. The United States Government does not endorse products or manufacturers. Technical Report Documentation Page Report No. 2. Government Accession No. 3. Recipient's Catalog No. DOT HS 808 078 I. Title and Subtitle Report Date November 1993 Marijuana and actual driving performance Performing Organization Code 8. Performing Organization Report No. 7. Author's) Hindrik W.J. Robbe and James F. O'Hanlon IGVG 92-15 9. Performing Organization Name and Address 10. Work Unit No. (TRAIS) Institute for Human Psych opharmacology University of Limburg 11. Contract or Grant No. Abtstraat 2A DTNH22-89-X-07722 6211 LS Maastricht - The Netherlands 13. Type of Report and Period Covered 12. Sponsoring Agency Name and Address Final Report (11/89-11/93) U.S. Department of Transportation National Highway Traffic Safety Administration 400 Seventh Street, S.W.
    [Show full text]
  • Cannabis State-By-State Regulations
    CANNABIS STATE-BY-STATE REGULATIONS By: Barry Weisz and Michael Rosenblum Updated August 2021 Michael Rosenblum is a former associate with Thompson Coburn. He now serves as Associate General Counsel at #1: CALIFORNIA Shryne Group, Inc. - a cannabis company. California has legalized both adult-use and medical marijuana, making it one of the most relaxed states in the nation with The Tracking Cannabis blog is proud to announce our latest state-by-state ranking of state cannabis regulations based regard to cannabis use. With the passage of the Compassionate Use Act (CUA) of 1996 (Proposition 215), California on how favorable they are to cannabis businesses. California leads the pack, but you might be surprised by which states became the first state to legalize medical marijuana use. It has since been followed by the Medical and Adult-Use Cannabis make the top — and bottom — of the list. Regulation and Safety Act, creating a uniform licensing regime for both medical and adult-use. California’s cannabis market recorded a record $4.4 billion in sales in 2020. Our guide provides a holistic review of the current cannabis laws in every state and the District of Columbia, from most favorable to cannabis businesses to most restrictive. In addition, you can find each state in alphabetical order below. Jurisdictions are ranked on the following factors: CUA allowed patients and their primary caregivers to obtain marijuana for medical use by the patient without subjecting either to criminal prosecution. The Act authorized medical use for patients with one of 11 specified conditions and also 1. Cannabidiol (CBD) derived from marijuana plants (THC concentration equal to or greater than 0.3 percent on a dry included a general purpose clause that authorized use for any condition that substantially limited a person’s ability to weight basis) – legality and required qualifications; conduct a major life activity as defined in the ADA.
    [Show full text]
  • James Gibson & Lucas Dvorak, Mid Iowa Drug Task Force
    Presented by Det./Sgt. James Gibson & Investigator Lucas Dvorak Mid Iowa Drug Task Force – 641-754-6392 Public Speaking Video What is midtf Mid Iowa Drug Task Force – 9 agencies Marshall, Tama, Hardin, Grundy Work with DEA, FBI, ATF, ICE, US Marshalls, IRS Concerned citizen complaints Educate public Pretty much ninjas. OBJECTIVES Show local drug trends. Be able to identify paraphernalia associated with drug use. Identify various equipment and chemicals used in the manufacturing of methamphetamine and BHO extraction. Be able to properly handle illegal drug manufacturing waste. Create general drug awareness. Trending in Iowa: Drug Use at a Glance – Aug. 2015 13th lowest rate of illicit drug use & 14th lowest rate of Rx abuse in US. Youth substance abuse declined steadily over last decade. Meth labs down 88% vs. peak of ten years ago (174 vs. 1,500) Meth use treatment 11th highest in US. Underage & binge drinking exceed national average OD deaths from Rx at all time highs. Fastest growing form of substance abuse. Marijuana “concentrates” on the rise. Synthetic drugs are new & changing threat. Iowa Drug-related Traffic fatalities - # Killed in 2013 who tested positive for illicit drugs 20 – Marijuana 10 – Prescription 8 – Meth 2 – Cocaine 94 – Alcohol 21 had drugs & alcohol in system 19 were solely drug-related IDOT,2013 MARIJUANA Marijuana is a green, brown, or gray mixture of dried, shredded leaves, stems, seeds, and flowers of the hemp plant (Cannabis sativa). Cannabis is a term that refers to marijuana and other drugs made from the same plant. MARIJUANA - HOW IS IT COMMONLY USED Roll loose marijuana into a cigarette (called a joint) Smoke it in a pipe or a water pipe, sometimes referred to as a bong.
    [Show full text]
  • The American Herbal Pharmacopoeia Cannabis Inflorescence
    American Herbal Pharmacopoeia ® Cannabis Inflorescence Editors and Technical Advisors Cannabis spp. Roy Upton RH DAyu American Herbal Pharmacopoeia® Scotts Valley, CA Lyle Craker PhD PAGES University of Massachusetts Standards of Identity,MONOGRAPH Analysis, and Amherst, MA Quality Control 64 Mahmoud ElSohly PhD University of Mississippi University, MS Aviva Romm MD CPM American Herbal Pharmacopoeia® Lennox, MA Ethan Russo MD COMPLETE GW Pharmaceuticals Salisbury, UK OF MONOGRAPH Michelle Sexton ND BS Americans for Safe Access Washington, DC The Center for the Study of Cannabis and Social Policy Seattle, WA Research PREVIEWAssociates Jahan Marcu PhD Green Standard DiagnosticsCOMPLETE Henderson, NV Diana Swisher MA American Herbal Pharmacopoeia® Scotts Valley, CA Table of Contents Nomenclature 2 Constituents 32 Botanical Nomenclature Botanical Family Pharmaceutical Nomenclature Analytical 40 Pharmacopoeial Definition Thin-Layer Chromatography (TLC) Common Names High Performance Liquid Chromatography (HPLC) Gas Chromatography with Flame Ionization Detection (GC-FID) Limit Tests Identification 2 Foreign Organic Matter Botanical Identification Total Ash Macroscopic Identification Acid-insoluble Ash Organoleptic Characterization Loss on Drying Microscopic Identification Pesticide Limits Microbial and Fungal Limits Metal Limits Commercial Sources and Handling 18 Solvent Residues Sourcing Cultivation Harvest Drying International Status 51 Packaging Storage Natural Contaminants and Adulterants References 55 Qualitative Differentiation Sustainability and Environmental Impact Documentation of Supply Growing and Harvesting Guidelines PAGES Security MONOGRAPH Suppliers and Dispensaries 64 COMPLETE Legal Notification The following Standards of Identity,OF Analysis, and Quality Control of Cannabis are intended to provide scientifi- cally valid methods for the analysis of cannabisMONOGRAPH and its preparations that can be used to comply with state and federal regulations and policies.
    [Show full text]
  • If You Have Issues Viewing Or Accessing This File Contact Us at NCJRS.Gov
    If you have issues viewing or accessing this file contact us at NCJRS.gov. '-'\ Q ..M ;.), ....... '"'!'; .. 92d Congress } COMlVIITTEE PRINT 1st Session MARIHUANA AND HEALTH A REPORT TO THE CONGRESS FROM THE SECRETARY, DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE 't SUBCOMMITTEE ON ALCOHOLISM AND NARCOTICS OF THE COMMITTEE ON LABOR AND PUBLIC WELFARE UNITED STATES SENATE NCJRS 7 ,9&9 "Il"\ONS M~l\S1Qtirl $ \ u Printed for the use of the Committee on Labor and Public Welfare U.S. GOVERNMENT PRINTING OFFICE 56-310· WJ\cSHINGTON : 1971 COMl\IITTEE ON LABOR AND PUBLIO WELFARE HARRISON A. WILLIAlIIS, JR., New Jersey, Ohalrman JENNINGS RANDOLPH, West VIrgInIa JACOB K. JAVl'rl'l. New York CLAIBORNE PELL, Rhode IRlund WINSTON L. PROlJTY, Vermont EDWARD M. KENNEDY, lIIussnchusctt PETER H. DOJlIINICK, Colorndo GAYLORD NELSON, WIsconsIn RICHARD S. SCHWEIKER, Pennsylvnnla WALTER F. JlWNDALE, lIIlnnesota BOB pACKWOOD, Oregon THOJlIAS F. EAGLETON, MissourI IWBERT ~'AFT, JR., Ohio ALAN CRANSTON, Cnllfornln J. GLENN BEALL, JR., Mm'ylnnd HAROLD E. HUGHES, Iowa ADLAI E. SU!lVENSON III, IllInois STEWAHT E.lIIcCLUIlE, St(/jJ Director RODEIlT E. NAGLE, Gcncml OO/IIISc! Roy H.lIIILLENsON, Millo/'itll StuD Dircctor EUGENE MIT1'ELMAN, M-Inol'itv Oounscl SUnCOMMl'l'l'EE ON ALCOHOLISM AND NARCOTICS HAROLD E. HUGHES, Iown, Ollah'man JENNINGS RANDOLPH, West VIrgInia BOB PACKWOOD, Oregon HARRISON A. WILLIAMS, JIl., New Jersey JACOB Ie JAVITS, New York EDWARD JlI. KENNEDY, MnssnclJllsctts I'l!lTER H. DOMINICK, Colorndo WALTER F. JlroNDALE;lnl\~~,so~a~... RICHARD S. SCHWEIKER, PenDsylvnnla ALAN CRANSTON, Cullfornla t !L.. •. ,.J, ~;1:- WAD/') CtARI{, 00111l8C! RICHARD J.
    [Show full text]
  • Reflection on Adding Oil to the Fire Medical Marijuana Uses For
    Reflections on Adding Oil to the Fire Medical Marijuana Use for Seizures in Pediatric Epilepsy Patients Charuta Joshi MBBS Clinical Professor Pediatric Neurology Director of Pediatric Epilepsy Objectives At the end of this talk the audience will: 1. Know the history behind the recent “ Marijuana Revolution” 2. Review published literature on effectiveness of CBD 3. Review trials of CBD in Iowa I shall be discussing a NON FDA approved and ILLEGAL substance I have NO CONFLICTS OF INTEREST My initial “exposure” to the substance • Charas • Hashish • Bhang • Ganja History of Cannabis Use History of Cannabis use • China • India- Atharva Veda • Egypt Hemp fibre use for rope, clothing, bowstrings, paper, livestock, feed, medicine, construction material, seeds, seed oils etc Medicinal uses • China- menstrual disorders, gout, rheumatism, malaria, constipation, absent mindedness • Islamic countries- nausea, vomiting, epilepsy, inflammation, pain, fever • Western medicine- inflammation and pain ( before aspirin); W. Gowers - epilepsy • Recent uses- glaucoma, spasticity, nausea, insomnia, anxiety, epilepsy- Bill passed in Colorado 2008 Where it all began…recently… August 2013- Dr Sanjay Gupta Charlotte Figi - Dravet syndrome Seizures 300/wk ..to 2-3/ month Dravet syndrome- Charlotte Dravet Charlotte Dravet • Initially normal children • Febrile status epilepticus • Normal till about age 2 • Regression thereafter • Increased risk for SUDEP( sudden unexplained death in an epilepsy patient) Terms used • Marijuana= preparation of the cannabis plant -used
    [Show full text]
  • Antimicrobial Efficacy of Cannabis Sativa L. (Bhang): a Comprehensive Review
    Int. J. Pharm. Sci. Rev. Res., 44(1), May - June 2017; Article No. 26, Pages: 94-100 ISSN 0976 – 044X Review Article Antimicrobial Efficacy of Cannabis sativa L. (Bhang): A Comprehensive Review Chandni Tandon*, Priti Mathur Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus-226028, India. *Corresponding author’s E-mail: [email protected] Received: 20-02-2017; Revised: 18-03-2017; Accepted: 25-04-2017. ABSTRACT Therapeutic products derived from plants are gaining popularity since long time and this is primarily due to their ability to overcome the side effects of allopathic forms of medicine. Besides this, multi-drug resistance by pathogens to currently used antibiotics triggered the search for identifying natural antimicrobial products that are effective in combating infections. Considering this, we have focused on the various investigations related to antimicrobial properties of the well-known wildly growing plant i.e., Cannabis sativa. Cannabis sativa is an annual herbaceous plant belonging to the family Cannabaceae. It is known by various names worldwide as Marijuana, Bhang, Dogga, Hashish, Grifa etc. The plant and its preparations have many medicinal properties including antimicrobial properties, which are thought to be beneficial for human health. From our review study, we have found that the leaves of a plant can act as most prominent source for isolating antimicrobial compounds. Also Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Candida albicans were found most susceptible towards the different plant extracts, indicating the greater effectiveness of the plant in diseases caused by these pathogens. Furthermore ethanol, methanol and distilled water can be considered as the best solvents for extracting different plant secondary metabolites.
    [Show full text]
  • STORY COUNTY BOARD of HEALTH TENTATIVE AGENDA TUESDAY, April 2, 2019 2:00 PM
    STORY COUNTY BOARD OF HEALTH TENTATIVE AGENDA TUESDAY, April 2, 2019 2:00 PM Public Meeting Room* - Story County Administration (900 6th Street) – Nevada, Iowa 1. CALL TO ORDER 2. APPROVAL OF AGENDA 3. APPROVAL OF MINUTES Documents: MINUTES 020519.PDF 4. CONSENT AGENDA All items listed under the consent agenda will be enacted by one motion. There will be no separate discussion of these items unless a request is made prior to the time the Board votes on the motion. 4.I. Consideration Of Contract Between Iowa Department Of Natural Resources And Story County Board Of Health Documents: AMENDED CONTRACT.PDF 5. PUBLIC FORUM This is the time for members of the public to offer comments concerning matters not scheduled to be heard before the Board of Health. 6. ADDITIONAL ITEMS 6.I. Discussion And Consideration Of Local Public Health Services FY20 Application - Les White Documents: FY20 LOCAL PUBLIC HEALTH SERVICES APPLICATION.PDF 6.II. Discussion Of Health Impact Assessments - Leanne Lawrie Harter Documents: HEALTH IMPACT ASSESSMENTS.PDF 6.III. Discussion Of Story County Swimming Pool Ordinance - Matt Cory 6.IV. Discussion And Consideration Of Watershed Assessment Implementation Matrix And Working Group Program And Recommendation To The Board Of Supervisors - Leanne Harter IMPLEMENTATION MATRIX 7. AGENCY AND DEPARTMENTAL REPORTS 7.I. Story County Public Health; Treasa Ferrari, Patsy Beese 7.II. YSS; Denise Denton Documents: FEBRUARY 19 YSS REPORT.PDF THE MARIJUANA REPORT MARCH 6, 2019.PDF POTENT CANNABIS HEIGHTENS PSYCHOSIS RISK.PDF CANCER PATIENTS AND MJ USE.PDF NEVADA COMMUNITY CONVERSATION ON SUBSTANCE ABUSE FLYER.PDF 7.III.
    [Show full text]