DOCSLIB.ORG

United States Patent [191 [11] Patent Number: 5,696,273 Andre Et A]

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
United States Patent [191 [11] Patent Number: 5,696,273 Andre Et A] USOO5696273A United States Patent [191 [11] Patent Number: 5,696,273 Andre et a]. [45] Date of Patent: Dec. 9, 1997 [54] METHOD FOR SYNTHESIZING OTHER PUBLICATIONS CUCURBITINE Pn'ce. Pathophysiology. Clinical Concepts of Disease Pro [75] Inventors: Patrice Andre. Neuvilles aux Bois; cess~ 19,36~ PP- 36-37- ‘ _ valérie Thiery_ Clery St Andre; Gémld Webster s New World Dictionary. 1988. p. 36. Guillaumet‘ 01-16mm an of France World Patents Index Latest. AN 87-32998? [47]. Derwent Publications Ltd.. London. GB. & JP. S. 62234013 (Osaka [73] Assignee: Parfums Christian Dior. Paris. France Yak'lhin Kmky) 14 Oct- 1937 Chemical Abstract. vol. 82. No. 23. 1975. p. 40. abstract _ 149446a. Pharmacological (anthelminthic) study of Cucur [21] APPL N°" 476’646 bita. ,A.E. Gonzalez a a1. [22] Filed; Jm 7, 1995 Scienta Sinica. vol. X. No. 7. 1961.T.-T. Sun et a1. “Chemi cal studies on cucurbita moschata duch". pp. 852-859. Related US. Application Data Journal of the Chemical Society. Chemical Communica tions. 1973. H]. Monteiro, “New synthesis of the ami [62] Division of Ser. No. 108,601 , ?led as PCT/FR92/00164 Feb. no-acid (+)-Cucurbitine”. p. 2. 24’ 1992, abandmed- Chemical and Pharmaceutical Bulletin. vol. 35. No. 9. Sep. [30] Foreign. Application. Pl'lol'lty. Data ..'. 5183;135:2149?' t.‘ nzym esandcatalsts.H.Pi y g Feb. 28, 1991 [FR] France ................................. .. 9102420 J. Fable. “Methoden der Organischen Chemie". vol. E5. Georg Thieme Verlag pp. 534-543. (1973). [5 .................... .. C071) 207/36 Derwent Publications Ltd. 52051033AN (Ogawa) 23 Apr.& 1977. [52] US. Cl. 548/531; 548/542; 548/550 world Patents Indcx Latest, 1937‘ AN 37473336 [39]_ [58] Field of Search 5481531. 542, Derwent Publications Ltd. 62087241 (Lion Corp.) 21 Apr. 5481550 1987. World Patents Index Latest. 1987. AN 87-105806 [15]. [56] References Cited Derwent Publications Ltd. 52051033 (Shiseido) 9 Mar. 1987. Us PATENT DOCUMENTS World Patents Index Latest. 1987. AN 97-032891 [05]. Derwent Publications Ltd. 62087241 (Shiseido) 19 Dec. 4,255,418 3/1981 1986 4,511,559 4/1985 4,621,746 11/1986 Primary Examiner-Floyd D. Higel 4,883,659 11/1989 Attorney Agent, or F inn-Sherman and Shalloway 4,942,153 7/1990 4,980,038 12/1990 [57] ABSTRACT 5,039,516 8/1991 5,113,507 6119” The invention relates to the use of cucurbitine or exu'acts of 5,128,139 7/1992 Cucurbitaceae pips for the preparation of a cosmetic or 5,164,182 11/1992 pharmaceutical. in particular dermatological, composition 5,165,935 11/1992 Andre .................................... .. 429/450 having an?a?cfgic activity 01- fol- [hc preparation of C05. metic or pharmaceutical compositions having a reduced risk FOREIGN PATENT DOCUMENTS of being a?crggnic. 2522500 9/1983 France. 2673626 9/1992 France ................................. .. 548/531 7 Claims, 2 Drawing Sheets U.S. Patent Dec. 9, 1997 Sheet 1 of 2 MickaeLis curve Initial rate AA/min 0 132 265 530 nmol histidine without effector ' —---- tritoqualine ----- cucurbitine FIG.1 US. Patent Dec. 9, 1997 Sheet 2 of 2 5,696,273 RIA assay nmol histamine liberated ‘601i I40" I20" I00" 80.. 60- 40‘ - 20 : : 1 5 i ‘ § 10 U \ 2 3 4 5 s 7 time (minutes) without effector —---— tritoqualine --- cucurbitine 5,696,273 1 2 METHOD FOR SYNTHESIZING enabling the allergenic potential of cosmetic or CUCURBITINE pharmaceutical. in particular dermatological. compositions to be decreased. This application is a division of application Ser. No. The object of the present invention is also to solve the new 08/108.601. ?led Sep. 28. 1993. now abandoned; which in technical problem that consists in providing an approach turn entered the National phase based on International enabling the synthesis of cucurbitine to be carried out by a Application PCT/FR92/O0l64 ?led Feb. 24. 1992. simple synthesis process. necessitating a miniruum number The present invention relates essentially to the use of of steps. in good yields. cucurbitine for the preparation of antiallergic cosmetic or The present invention enables all these technical problems pharmaceutical. in particular dermatological, compositions, to be solved simply. reliably and reproducibly of a cosmetic and to a process involving application thereof. 10 or pharmaceutical. in particular dermatological. composition Cucurbitine. or 3-amino-3-pyrrolidinecarboxylic acid. of having antiallergic activity. the following formula I: According to a particular variant of embodiment. the preparation in question is of a cosmetic or pharmaceutical. C OOH (1) in particular dermatological. composition intended for the 15 NH; prevention or symptomatic treatment of allergic manifestations. irrespective of their origin and their point of application, in particular the bronchi. skin and eye. Thus. the N said composition is intended. in particular. for the prevention l H or symptomatic treatment of allergic or exercise-induced bronchial asthma. hay-fever. spasmodic tracheitis and is a natural. water-soluble amino acid found in Cucurbita rhinitis. urticaria. other allergic eruptions. eczema. red ceae (see V. H. Mihranian et al.. LLOYDIA (1968). 31 (1) blotches or skin irritations of allergic pruritus. 23-29). Quincke’s oedema. allergic conjunc?vitis and also allergic Cucurbitine is known as an antiparasitic. especially as an reactions of medicinal anthelrnintic against Schistosoma japonicurn. (Morimoto Y. 25 In the more particular ?eld of cosmetology. the said et al.. Chem. Pharm. Bull. (1987) 35 (9) 3845-3849). Cucurbitine may be obtained by means of extraction in composition is intended advantageously for lines of products laevorotatory form. or synthetically in racemic form. Among which are hypoallergenic or for sensitive or irritable skins. the various methods of synthesis of cucurbitine, special Cucurbitine may be used either in free form. or in the form mention may be made of the synthesis method of H. .l. of one of its cosmetically or pharrnaceutically. in particular Monteiro. J. Chem. Soc.. Chem. Commun. (1973) 2. This dermatologically. acceptable salts or esters. The abovemen method leads to only relatively low yields of racemic tioned salts and esters may be prepared by conventional cucurbitine. Another synthesis method enables the two opti processes which are well known to a person skilled in the art. cal isomers of cucurbitine to be obtained separately. This is Among salts. the mono- and dihydrobromide and the mono the method of Morimoto et al.. Chem. Pharm. Bull. (1987) and dihydrochloride may be mentioned Among esters. the 35 (9) 3845-3849. which is a stereospeci?c enzymatic 35 methyl ester and the ethyl ester may be mentioned. method of synthesis by the use of a pig liver esterase. This According to an advantageous variant. the above method is. however, complicated. and necessitates a rela mentioned plant extract containing cucurbitine is an extract tively large number of steps. of Cucurbitaceae. especially of Cucurbita maxima Duch.. of It has now been discovered. unexpectedly. that cucurb Cucurbita pepo L. or of Cucurbita moschata Duch; itine inhibits the formation of histamine. a well-known preferably. it is an extract of pips or of fruit pulp. As a further mediator of allergies. and hence displays valuable hypohis preference. it is an extract of Cucurbitaceae pips. tarninaemic activity. This hypohistaminaernic activity According to a particular variant. the above-mentioned results from the inhibitory action of cucurbitine on histidine plant extract is an extract of Cucurbitaceae fruit pulp con decarboxylase. which is the enzyme responsible for the taining at least 0.5% by weight of curcubitine. conversion of histidine to histamine. As a result. the admin 45 According to an advantageous variant of embodiment. istration of cucurbitine contributes to decreasing the hista cucurbitine or one of its cosmetically or pharrnaceutically. in mine concentration in the blood serum and tissues. particular derrnatologically. acceptable salts or esters is This constitutes a considerable technical advance. since present at a concentration of 0.001% to 10%. and preferably allergic manifestations. in particular pulmonary and cutane 0.01 to 5%. by weight of the total composition. ous allergies. are nowadays causing many problems for 50 According to a second aspect. the present invention also therapists. who have a limited number of active substances relates to a cosmetic composition. characterized in that it at their disposal and. in addition. some of these substances comprises. as active ingredient. cucurbitine or one of its can display side-effects. Thus. a considerable need conse cosmetically acceptable salts or esters. or a plant extract quently exists for the development of a new preventive and containing it. where appropriate in a cosmetically acceptable curative composition for allergies. $5 excipient. vehicle or carrier. Thus. the main objective of the present invention is to According to an advantageous variant. the above solve the technical problem that consists in providing an mentioned plant extract is an extract of Cucurbitaceae as approach enabling the formation of histamine. a mediating de?ned above. agent in the context of allergic manifestations. to be inhib According to a preferred variant of embodiment. cucur ited in order to enable allergic manifestations to be pre bitine or one of its salts or esters is present in an amount vented and treated. which is effective for displaying antiallergic activity. espe According to another aspect. the main objective of the cially at a concentration of 0.001% to 10%. and preferably
Load more

Recommended publications
  • A Simple Question... Histamine
    A simple question... How was histamine discovered ? • by chemical synthesis … • from the analysis of plant extracts (ergot fungus Claviceps purpurea) • from the analysis of animal tissues extracts • through none of these approaches Antihistamines 21/03/2010 1 Histamine ... obtained by synthetic chemist in 1907 …as a chemical curiosity … detection of an identical compound in an extract from ergot fungus … and shown to cause a marked vasodilatation a similar effect is seen with tissues extracts produces a similar picture as a very severe allergic reaction recognized as a "biological" molecule (and not a product from putrefaction in 1927 ... Antihistamines 21/03/2010 2 1 From histidine to histamine ... HN HN CH CH NH 2 2 CH2 CH2 NH2 N COOH N L-histidine decarboxylase First inhibitor tritoqualine of histmine action … commercialized in France (HYPOSTAMINE ) Antihistamines 21/03/2010 3 Localization of histamine total blood leucocytes mastocytes 1. blood plasma other leucocytes 2. tissues ... the word comes from ("histos" = tissue !!) • skin • lung • gastrointestinal tract • central nervous system Antihistamines 21/03/2010 4 2 Actions of histamine • of capillary permability and vasodilatation cutaneous rednesses signs inflammation • bronchoconstriction important with the guinea-pig but under H2 retrocontol in man • of HCl secretion (pariteal cells of the stomach) • neurotransmission awakening reactions, tachycardia, hypertension nauseas, vomitting migraines neurological and comportmental signs Antihistamines 21/03/2010 5 Rappel:
    [Show full text]
  • Selective Reaction Monitoring (SRM) Daten Von Mehr Als 900 Xenobiotika Für Aufbau Und Validierung Von LC-MS/MS Analysen
    T + K (2008) 75 (3): 149 Selective Reaction Monitoring (SRM) Daten von mehr als 900 Xenobiotika für Aufbau und Validierung von LC-MS/MS Analysen Brunhilde Güssregen, Stefanie Schröfel, Markus Nauck, Torsten Arndt Bioscientia Institut für Medizinische Diagnostik GmbH, Konrad-Adenauer-Str. 17, 55218 Ingelheim; e-mail: [email protected] Die Flüssigkeitschromatographie-Tandem-Massenspektrometrie (LC-MS/MS) hat in den letz- ten Jahren eine zunehmende Bedeutung nicht nur in der klinisch-chemischen sondern auch in der toxikologischen Analytik gewonnen. Sie kann heute neben den klassischen Verfahren wie UV/VIS-Spektrometrie, Hochleistungs-Flüssigkeitschromatographie (HPLC) und Gaschro- matographie-Massenspektrometrie (GC-MS) als integraler Bestandteil der qualitativen und quantitativen Analytik gewertet werden. Dies drückt sich nicht zuletzt in der steigenden Zahl der Meldungen von mit LC-MS/MS erhobenen GTFCh- Ringversuchsergebnissen aus. Die Ursachen für diese Popularität sind vielfältig. Es sind u. a. einige analytische Vorteile im Vergleich zu den o. g. Analysentechniken: Vereinfachte Probenvorbereitung (z. B. ohne Derivatisierungsreaktionen), Einsatz geringerer Probenmengen, Kürzere Chromatographie- und dadurch Analysezeiten, Spezifitätssteigerung durch die Kombination von minimal 4 Identifizierungskriterien (Retentionszeit, Massenübergänge 1 und 2 [SRM 1 und SRM 2], Intensitätsverhältnis von SRM1 und SRM2), deren Anzahl bei Verwendung von mehr als 2 SRM erhöht werden kann, Eignung für alle löslichen Substanzen unabhängig von ihrer Fähigkeit, zerstörungs- frei in die Gasphase überführt werden zu können. Derzeitige Nachteile der LC-MS/MS im Methodenvergleich sind: Fehlende Standardisierung sowohl der Chromatographie- als auch der Tandem-Mas- senspektrometrie-Analysenteilschritte, Variabilität der Massenspektren infolge der vglw. milden Fragmentierungsbedingun- gen, Fehlen von allgemein verfügbaren LC-MS/MS-Spektren- und/oder Massenübergangs (SRM)-Bibliotheken mit einer der Pfleger-Maurer-Weber Bibliothek [1] oder der Pragst et al.
    [Show full text]
  • The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances
    WHO/PSM/QSM/2006.3 The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2006 Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Medicines Policy and Standards The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 © World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]
  • Pharmaceutical Appendix to the Tariff Schedule 2
    Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9
    [Show full text]
  • APO-Glimepiride 1 Mg Tablets: Educator Will Show You How and When to Do This
    APO-Glimepiride Contains the active ingredient glimepiride Consumer Medicine Information For a copy of a large print leaflet, Ph: 1800 Ask your doctor if you have any questions Talk to your doctor or pharmacist if you are 195 055 about why this medicine has been prescribed not sure whether you should start taking this for you. medicine. What is in this leaflet This medicine is available only with a doctor's Before you start to take it prescription. Tell your doctor if: This leaflet answers some common questions There is no evidence that this medicine is about APO-Glimepiride. It does not contain all of addictive. 1. You have allergies to: the available information. - any other medicines - lactose It does not take the place of talking to your doctor Before you take this medicine or pharmacist. - any other substances such as food, preservatives, or dyes All medicines have risks and benefits. Your When you must not take it 2. You have or have had any medical doctor has weighed the risks of you taking this Do not take this medicine if you have had an conditions, especially the following: medicine against the benefits this medicine is allergic reaction to: expected to have for you. - liver problems • glimepiride or other sulfonylureas - kidney problems Ask your doctor or pharmacist if you have any • antibiotics called sulphonamides - a deficiency in the enzyme in your body concerns about taking this medicine. • thiazide diuretics (a type of fluid or water called glucose-6-phosphate dehydrogenase Keep this leaflet with the medicine. tablets) (G6PD) You may need to read it again.
    [Show full text]
  • Marrakesh Agreement Establishing the World Trade Organization
    No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX
    [Show full text]
  • BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available
    BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] BMJ Open Pediatric drug utilization in the Western Pacific region: Australia, Japan, South Korea, Hong Kong and Taiwan Journal: BMJ Open ManuscriptFor ID peerbmjopen-2019-032426 review only Article Type: Research Date Submitted by the 27-Jun-2019 Author: Complete List of Authors: Brauer, Ruth; University College London, Research Department of Practice and Policy, School of Pharmacy Wong, Ian; University College London, Research Department of Practice and Policy, School of Pharmacy; University of Hong Kong, Centre for Safe Medication Practice and Research, Department
    [Show full text]
  • Sustained Release Composition and a Method of Preparing Pharmaceutical Compositions
    Office europeen des brevets (fi) Publication number : 0 654 263 A1 @ EUROPEAN PATENT APPLICATION @ Application number : 94308493.9 @ Int. CI.6 : A61K 31/135, A61 K 31/485, A61K9/16 (22) Date of filing : 17.11.94 (30) Priority : 23.11.93 GB 9324045 Inventor : Leslie, Stewart Thomas 01.03.94 GB 9403922 4 Babraham Road 09.03.94 GB 9404544 Cambridge (GB) 14.03.94 GB 9404928 Inventor : Malkowska, Sandra Therese 14.06.94 GB 9411842 Antoinette 09.06.94 EP 94304144 21 Broadway, 29.04.94 EP 94303128 Wilburton Ely, Cambridge (GB) Inventor : Prater, Derek Allan (43) Date of publication of application : 28 Pearson Close 24.05.95 Bulletin 95/21 Miltorl( Cambridge (GB) Inventor : Knott, Trevor John @ Designated Contracting States : ti^^a^ R<£m AT BE CH DE DK ES FR GB GR IE IT LI LU MC Wickford, Essex (GB) NL PT SE Inventor : Heafield, Joanne 1 Bell Lane Fenstanton, Cambridge (GB) (FT) Applicant : Euro-Celtique S.A. Inventor : Challis, Deborah 122 Boulevard de la Petrusse Thurland Top, Luxemburg (LU) Mill Lane, Hildenborough _ Tunbridge, Kent, TN11 9LU (GB) (72) Inventor : Miller, Ronald Brown Schutzermattstrasse Basle, 4051 (CH) @ Representative : Lamb, John Baxter MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS (GB) (54) Sustained release composition and a method of preparing pharmaceutical compositions. (57) A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechani- cal working with the optional addition of a low percentage of the carrier or diluent.
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • 2 12/ 35 74Al
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 22 March 2012 (22.03.2012) 2 12/ 35 74 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/16 (2006.01) A61K 9/51 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 9/14 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP201 1/065959 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 14 September 201 1 (14.09.201 1) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 61/382,653 14 September 2010 (14.09.2010) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, NANOLOGICA AB [SE/SE]; P.O Box 8182, S-104 20 ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, Stockholm (SE).
    [Show full text]
  • Wo 2008/127291 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 23 October 2008 (23.10.2008) WO 2008/127291 A2 (51) International Patent Classification: Jeffrey, J. [US/US]; 106 Glenview Drive, Los Alamos, GOlN 33/53 (2006.01) GOlN 33/68 (2006.01) NM 87544 (US). HARRIS, Michael, N. [US/US]; 295 GOlN 21/76 (2006.01) GOlN 23/223 (2006.01) Kilby Avenue, Los Alamos, NM 87544 (US). BURRELL, Anthony, K. [NZ/US]; 2431 Canyon Glen, Los Alamos, (21) International Application Number: NM 87544 (US). PCT/US2007/021888 (74) Agents: COTTRELL, Bruce, H. et al.; Los Alamos (22) International Filing Date: 10 October 2007 (10.10.2007) National Laboratory, LGTP, MS A187, Los Alamos, NM 87545 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY,BZ, CA, CH, (30) Priority Data: CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, 60/850,594 10 October 2006 (10.10.2006) US ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, (71) Applicants (for all designated States except US): LOS LR, LS, LT, LU, LY,MA, MD, ME, MG, MK, MN, MW, ALAMOS NATIONAL SECURITY,LLC [US/US]; Los MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, Alamos National Laboratory, Lc/ip, Ms A187, Los Alamos, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, NM 87545 (US).
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]