Sara Cherry, PhD Associate Professor Department of Microbiology Perelman School of Medicine University of Pennsylvania
Title: “Using gene c approaches to study an viral immunity”
Monday, October 28, 2013 Meakins Amphitheatre | Room 521, 12:00 PM McIntyre Medical Sciences Building
“Viral pathogens are a common cause of morbidity and mortality in both the developing and developed worlds. Viruses have not only developed highly effec ve strategies to hijack cellular machinery and to subvert hosts' immune responses, but they have evolved broad host ranges, spanning arthropods and mammals. For vector‐ borne viruses infec on of the insect host is non‐pathogenic, while infec on of mammals is associated with disease, sugges ng that these viruses use different strategies to move through each host. Li le is known about the host factors required for the replica on cycles of these viruses in either of their host genera, and less is understood about the hosts' innate immune pathways that act to restrict pathogenesis. We are performing genome‐wide RNAi screens in Drosophila cells to iden fy innate immune mechanisms ac ve against a number of arthropod‐borne viruses including the flaviviruses West Nile virus and Dengue, the bunyavirus Ri Valley Fever virus, the alphavirus Sindbis and the rhabdovirus Vesicular Stoma s virus. Our recent studies have revealed genes and pathways that restrict infec on both in insects and mammals and these will be discussed.”
This seminar is mandatory for Graduate students LOCATION: McIntyre Medical Sciences Building Room 521, 12:00 PM HOSTED BY: DRS. MAYA SALEH AND SILVIA VIDAL
If you would like to book a one‐on‐one mee ng with Dr. Cherry, send your request to [email protected]