DOCSLIB.ORG

The European Molecular Biology Laboratory Magazine Issue 93 Summer 2019

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The European Molecular Biology Laboratory Magazine Issue 93 Summer 2019 The European Molecular Biology Laboratory Magazine Issue 93 Summer 2019 Code Synapse Robots grow bio-inspired shapes Nucleus Wielding the genetic scissors Cultures Twenty years of EMBLEM Contents Nucleus Feature stories 14 Wielding the genetic scissors What CRISPR may bring for the future of biology, and how it is used at EMBL 20 24 Programming: How coding opens up language scientifi c data How computer processing The increasing of human language is importance of code in the harnessed by EMBL biological sciences scientists 28 32 Drawing knowledge Decoding ageing A conversation about art– Ageing, longevity, the science collaborations naked mole-rat and us and the importance of drawing in biology 2 EMBLetc. SUMMER 2019 Synapse News stories 5 New functionalities for cells 9 Cell death trigger in tuberculosis bacteria 6 Global microbial signatures for colorectal cancer 9 A worm’s sense of the world 6 Transcription factors controlled by 10 Many gut microbes may originate in DNA sequence the mouth 7 A DNA search engine for microbes 10 Using light to stop itch 7 New method to study gene 10 Genomes of all known UK species to expression in yeast cells be sequenced 8 Role reversal: RNA controls protein 11 Hundreds of tiny robots grow bio- function inspired shapes 8 ATP affects proteome-wide solubility 12 Foundation stone laid for EMBL Imaging Centre Cultures EMBL community stories 36 Twenty years of EMBLEM 42 Top tips for teaching yourself to code! 46 Building engagement 48 The donor’s code 50 Editing the ethical code 52 Awards & honours Alumni 53 Celebrating alumni worldwide 53 Alumni Association Board elections 54 2019 alumni awards 56 Fun with fern photography 58 Bringing science to life 59 EMBL’s coding past THE EUROPEAN MOLECULAR BIOLOGY LABORATORY MAGAZINE 3 MASSIMO DEL PRETE/EMBL Word to remember Mitochondria Plural noun (singular mitochondrion) Pronunciation: /ˌm a ɪ t əˈk ɒ nd r ɪə / Often described as the powerhouses of the cell, mitochondria are cellular Editorial components that produce the cell’s energy currency, adenosine triphosphate (ATP). Codes are everywhere. In biology, the most obvious examples might be the codes in DNA and RNA, but whenever scientists seek to You inherit your mitochondria understand how a system works, or piece together observations to almost exclusively from your reveal deeper truths, they’re cracking codes of one kind or another. mother (p. 50), and they may play a role in ageing (p. 34). In this issue, we explore how CRISPR-Cas9 – a tool for editing the DNA code – is used at EMBL (p. 14), and Science and Society speaker Tim Lewens analyses the ethical side of gene editing (p. 50). We also Publisher meet members of the EMBL community who are teaching children European Molecular Biology Laboratory and teenagers how the nucleotides in DNA store information, using an even more beloved set of fundamental building blocks: Lego bricks Managing editor (p. 46). Edward Dadswell We find out how computer code is providing more efficient ways to Editors access and analyse biological data (p. 24), and how EMBL scientists Cella Carr are gaining new scientific insights by using computer algorithms for Mehrnoosh Rayner analysing language (p. 20). We also report on a new search engine for microbial genomes (p. 7), and EMBLers share the lessons they Design learned on their coding journeys (p. 42). Designyard Finally, we take a look at the codes used in different worlds. We Printed by celebrate twenty years of EMBL’s technology transfer partner, ColorDruck Solutions EMBLEM, which takes fundamental science into the commercial sphere (p. 36). Manfred Lautenschläger, funder of the EMBL Contact Lautenschläger Summer School, discusses his code for giving (p. 48), [email protected] and we explore codes from various disciplines as an artist and a historian visit EMBL (p. 28). Cover illustration Aleksandra Krolik Edward Dadswell Editor NEWS.EMBL.DE 4 EMBLetc. SUMMER 2019 Synapse New functionalities for cells EMBL scientists create membraneless organelle to build proteins in a living cell Typical cellular processes are GEMMA ESTRADA GIRONA seen as encapsulated, isolated, and are represented as repetitive structures in a city. The making of a new organelle is highlighted as a new building that is more dynamic and flexible, and is not fenced. BY IRIS KRUIJEN Estrada Girona. “The novelty we membraneless organelle and to make introduce is the ability to use these sure that only one organelle per cell For the first time, scientists have in a confined space, the organelle, is formed. engineered the complex biological which minimises the effects on the process of translation into a designer host.” Edward Lemke – visiting group organelle in a living mammalian leader at EMBL, Professor at JGU cell. Research by the Lemke group at Wobbly wall-less organelles Mainz and Adjunct Director at the EMBL – in collaboration with JGU Translation is too complex to be IMB – led the project. He concludes: Mainz and IMB Mainz – used this contained in one single organelle “In the end, we aim to develop a technique to create a membraneless surrounded by a membrane. technique to engineer synthetic organelle that can build proteins Therefore, inspiration was drawn cellular organelles and proteins that from natural and synthetic amino from phase separation: the process do not affect the host machinery acids carrying new functionality. responsible for the formation at all. We want to create a tool that Their results allow scientists to of membraneless organelles in does not have any uncharacterised study, tailor and control cellular vivo, such as nucleoli or stress effects. The organelle should be a function in more detail. granules. Phase separation is used simple add-on that allows organisms by cells to locally concentrate to do custom-designed novel things “The organelle can make proteins specific proteins and RNAs. Even in a controlled fashion.” by using synthetic non-canonical though these wall-less organelles amino acids. Currently we know have wobbly boundaries, as they Reinkemeier, CD*, Girona, GE*, of more than 300 different non- interact dynamically with the Lemke, EA. Science, 29 March 2019. canonical amino acids – compared to surrounding cytoplasm, they can DOI: 10.1126/science.aaw2644 20 that are naturally occurring. We still do very precise tasks. The team are no longer restricted to the latter combines phase separation with FULL VERSION ONLINE: ones,” says co-first author Gemma cellular targeting to create their BIT.LY/embl-93-01 THE EUROPEAN MOLECULAR BIOLOGY LABORATORY MAGAZINE 5 Global microbial signatures for colorectal cancer Colorectal cancer is of colorectal cancer – the third identify microbial signatures for characterised by consistent most common cancer worldwide colorectal cancer,” says EMBL group changes in our gut bacteria – is unclear. To determine their leader Georg Zeller. “We validated influence, association studies aim these signatures in early cancer across continents, cultures to map how the microbes colonising stages and in multiple studies, so and diets the gut of colorectal cancer patients they can serve as the basis for future are different from those that inhabit non-invasive cancer screening.” BY IRIS KRUIJEN healthy subjects. Wirbel, J, Pyl, PT et al. Nature Cancers have long been known A study led by EMBL scientists Medicine, 1 April 2019. DOI: 10.1038/ to arise due to environmental focused on a process in which s41591-019-0406-6 exposures such as unhealthy diet or certain gut bacteria turn bile Thomas, AM, Manghi, P et al. Nature smoking. Lately, the microbes living acids that are part of our digestive Medicine, 1 April 2019. DOI: 10.1038/ in and on our body have entered the juices into metabolites that can be s41591-019-0405-7 stage as key players. The role that gut carcinogenic. “We used a rigorous FULL VERSION ONLINE: microbes play in the development machine learning analysis to BIT.LY/embl-93-02 Cellular signalling controls chromatin Transcription modification. factors controlled by DNA sequence EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation ALEKSANDRA KROLIK/EMBL BY PATRICK MÜLLER In cells, DNA exists in a highly To reveal the underlying compact form. The scaffolding mechanism, a team led by Daniel that enables this packaging of Panne – a former group leader DNA is made of proteins known as at EMBL Grenoble – studied p300, histones. More than 50 years ago, an enzyme that transfers acetyl and when. Now, the scientists have it became apparent that chemical groups and regulates cell growth discovered that the sequence of the modifications to these proteins are and division. The team found that DNA determines where the histone associated with gene activation. transcription factors – proteins is acetylated. One example of such a modification that control the expression of is acetylation – the addition of an genes – are the mediators between Ortega, E et al. Nature, 15 October acetyl chemical group. However, acetylation and cellular signalling. 2018. DOI: 10.1038/s41586-018-0621-1 precisely how cellular signals Transcription factors are known initiate this modification remained to control where in the genome FULL VERSION ONLINE: unclear. particular genes are expressed, BIT.LY/embl-93-03 6 EMBLetc. SUMMER 2019 Synapse A DNA New method to study search gene expression in engine for microbes yeast cells Scientists develop high- New search engine allows throughput yeast single-cell researchers to identify antibiotic resistance genes or RNA sequencing method mutations in real time BY OANA STROE Researchers at EMBL-EBI have combined their knowledge of bacterial genetics and web search algorithms to build a DNA search engine for microbial data. The search engine could enable researchers and public health agencies to use genome sequencing data to monitor the spread of antibiotic resistance genes. WÜSTEFELD TOBIAS The search engine, called Bitsliced Genomic Signature Index (BIGSI), The strands of RNA within a single fulfils a similar purpose to internet yeast cell can now be studied search engines, such as Google.
Load more

Recommended publications
  • An Interview with Maria Leptin
    Disease Models & Mechanisms 3, 136-137 (2010) doi:10.1242/dmm.005454 A MODEL FOR LIFE © 2010. Published by The Company of Biologists Ltd Embracing new ideas: an interview with Maria Leptin Maria Leptin works simultaneously in the independent fields of immunology and development. She is the new director of the European Molecular Biology Organization (EMBO) and runs a laboratory in Heidelberg, as well as one in Cologne. Here, she describes how she moved between fields and some of the mechanisms that she believes foster creative science. aria Leptin is not afraid to At that time, developmental biology was accept new challenges. Her beginning to use new molecular techniques early postgraduate work such as chromosome walking, which was in immunology and her allowed researchers to clone genes with recent work uses the ze- known locations, and other tools to under- brafishM as a model organism to understand stand genetics that were just becoming es- host-pathogen interactions. During the tablished. I was interested in a number of time in between, she switched both her re- things like transcription and gene regula- search focus and the model organism that tion in general, as well as the field of she used. As a group leader at the Max Drosophila development. I ended up de- DMM Planck Institute in Tübingen, she uncovered ciding spontaneously to join a lab working some of the pathways that regulate tissue on fly development at the MRC Laboratory differentiation and morphology during of Molecular Biology (LMB) in Cambridge, Drosophila development. Recent work although I originally hadn’t applied to this from her lab shows important similarities in group.
    [Show full text]
  • EMBO Press Release
    EMBO – excellence in the life sciences PRESS RELEASE Embargo: 8 June 2021, 14:00 CEST EMBO announces 64 newly elected members EMBO announces the election of 64 life scientists to its membership. 8 June 2021 – EMBO is pleased to announce that 64 life scientists have been elected to its membership. The new EMBO Members and Associate Members join the community of more than 1,800 leading life scientists. “I am delighted to welcome the new members into our organization and look forward to working with them,” says EMBO Director Maria Leptin. “An election to the EMBO Membership recognizes outstanding achievements in the life sciences. The new members will provide expertise and guidance that will help EMBO to further strengthen its initiatives.” The 64 newly elected members reside in 21 countries: 55 new EMBO Members reside in member states of the EMBC, the intergovernmental organization that funds the major EMBO Programmes and activities. Nine new EMBO Associate Members reside in Argentina, Australia, India, Japan, and the USA. 26 of the new EMBO Members (41%) are women. EMBO Members are actively involved in the organization. They serve on EMBO Council, Committees and Advisory Editorial Boards of EMBO Press journals, evaluate applications for EMBO funding, and mentor early-career scientists. Collectively, they can influence the direction of the life sciences in Europe and beyond. New members are nominated and elected by the existing EMBO Membership; it is not possible to apply to become a member. One election is held each year. The new EMBO Members will be formally welcomed at the annual EMBO Members’ Meeting between 27 and 29 October 2021.
    [Show full text]
  • EMBO Encounters Issue43.Pdf
    WINTER 2019/2020 ISSUE 43 Nine group leaders selected Meet the first EMBO Global Investigators PAGE 6 Accelerating scientific publishing EMBO publishing costs Review Commons Making our journals’ platform announced finances public PAGE 3 PAGES 10 – 11 Welcome, Young Investigators! Contract replaces stipend Marking ten years 27 group leaders join the programme EMBO Postdoctoral Fellowships EMBO Molecular Medicine receive an update celebrates anniversary PAGES 4 – 5 PAGE 7 PAGE 13 www.embo.org TABLE OF CONTENTS EMBO NEWS EMBO news Review Commons: accelerating publishing Page 3 EMBO Molecular Medicine turns ten © Marietta Schupp, EMBL Photolab Marietta Schupp, © Page 13 Editorial MBO was founded by scientists for Introducing 27 new Young Investigators scientists. This philosophy remains at Pages 4-5 Ethe heart of our organization until today. EMBO Members are vital in the running of our Meet the first EMBO Global programmes and activities: they screen appli- Accelerating scientific publishing 17 journals on board Investigators cations, interview candidates, decide on fund- Review Commons will manage the transfer of ing, and provide strategic direction. On pages EMBO and ASAPbio announced pre-journal portable review platform the manuscript, reviews, and responses to affili- Page 6 8-9 four members describe why they chose to ate journals. A consortium of seventeen journals New members meet in Heidelberg dedicate their time to an EMBO Committee across six publishers (see box) have joined the Fellowships: from stipends to contracts Pages 14 – 15 and what they took away from the experience. n December 2019, EMBO, in partnership with decide to submit their work to a journal, it will project by committing to use the Review Commons Page 7 When EMBO was created, the focus lay ASAPbio, launched Review Commons, a multi- allow editors to make efficient editorial decisions referee reports for their independent editorial deci- specifically on fostering cross-border inter- Ipublisher partnership which aims to stream- based on existing referee comments.
    [Show full text]
  • 58 Life Science Researchers Elected As New EMBO Members
    58 life science researchers elected as new EMBO Members Heidelberg, 23 May 2016 - EMBO today announced that 58 researchers in the life sciences were newly elected to its membership. 50 of the scientists reside in 13 different countries in Europe; eight Associate Members were elected from China, Japan, Lithuania, Singapore and the United States. New EMBO Members are elected annually in recognition of their contributions to scientific excellence. Their selection is a tribute to their research and achievements. “I am delighted by the addition of 58 outstanding scientists to our membership. I would like to congratulate them and welcome them to the EMBO community”, EMBO Director Maria Leptin stated. “By serving the principles of excellence and integrity through their views and actions, they make invaluable contributions to science and society.” The newly elected members and associate members are: New EMBO Members 2016 Adam Antebi Max Planck Institute for Biology of Ageing, Cologne, Germany M. Madan Babu MRC Laboratory of Molecular Biology, Cambridge, United Kingdom Laure Bally-Cuif Institut de Neuroscience Paris-Saclay, Gif-sur-Yvette, Franc, and Institut Pasteur, Paris, France Mohamed Bentires-Alj Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland Michael Brand Center for Regenerative Therapies, TU Dresden, Germany Dana Branzei IFOM, Istituto FIRC, Milan, Italy Frank Buchholz UCC, TU Dresden, Germany Ana I. Caño-Delgado Centre for Research in Agricultural Genomics, Barcelona, Spain Jason S. Carroll Cancer Research UK Cambridge Institute, Cambridge, United Kingdom Andrew P. Carter MRC Laboratory of Molecular Biology, Cambridge, United Kingdom Agnieszka Chacinska International Institute of Mol. & Cell Biology in Warsaw, Poland Kristina Djinović-Carugo Max F.
    [Show full text]
  • EMBO Welcomes Thirty Young Investigators
    EMBO welcomes thirty Young Investigators https://www.embo.org/news/press-releases/2020/embo-welc... ABOUT EMBO FUNDING & AWARDS EVENTS EMBO PRESS SCIENCE POLICY MEMBERS NEWS HISTORY Press releases Videos Newsletter – EMBOencounters EMBO in the news Reports & brochures Logos E-news EMBO welcomes thirty Young CONTACT [email protected] Investigators TTiillmmaannnn KKiieesssslliinngg HHeeiiddeellbbeerrgg,, 11 DDeecceemmbbeerr 22002200 – EMBO is pleased to announce that thirty life scientists have been Head, Communications selected as EMBO Young Investigators. They will join the existing network of 73 current and 384 former T. + 49 160 9019 3839 members of the programme. The new EMBO Young Investigators will receive financial and practical support for a period of four years, starting in January 2021. “We are delighted to welcome the new Young Investigators to the EMBO community and look forward to support them in leading and further developing their independent laboratories,” says EMBO Director Maria Leptin. “These 30 life scientists have demonstrated scientific excellence and are among the next generation of leading life scientists. Their participation in the EMBO Young Investigator Programme will help them in this critical phase of their careers.” The EMBO Young Investigator Programme supports life scientists who have been group leaders for less than four years and have an excellent track record of scientific achievements. They must carry out their research in an EMBC Member State, an EMBC Associate Member State (currently India and Singapore) or in countries or territories covered by a co-operation agreement (currently Taiwan and Chile). EMBO Young Investigators receive an award of 15,000 euros in the second year of their tenure and can apply for additional grants of up to 10,000 euros per year.
    [Show full text]
  • Downloaded from the Berkeley Drosophila Group Database [124]
    UC Berkeley UC Berkeley Electronic Theses and Dissertations Title Mechanisms of Transcriptional Precision in the Drosophila Embryo Permalink https://escholarship.org/uc/item/84x1d0pz Author Bothma, Jacques Publication Date 2013 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California Mechanisms of Transcriptional Precision in the Drosophila Embryo by Jacques Pierre Bothma Adissertationsubmittedinpartialsatisfactionofthe requirements for the degree of Doctor of Philosophy in Biophysics in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Michael Levine, Co-chair Professor Susan Marqusee, Co-chair Professor Nipam Patel Associate Professor Jan Liphardt Fall 2013 Mechanisms of Transcriptional Precision in the Drosophila Embryo Copyright 2013 by Jacques Pierre Bothma 1 Abstract Mechanisms of Transcriptional Precision in the Drosophila Embryo by Jacques Pierre Bothma Doctor of Philosophy in Biophysics University of California, Berkeley Professor Michael Levine, Co-chair Professor Susan Marqusee, Co-chair Contemplating how a single cell can turn into the trillions of specialized cells that make a human being staggers the imagination. We still do not fully understand how the information in a genome is interpreted by a cell to orchestrate this incredible process. One thing that we do know is that much of the complexity we see in the natural world comes down to how essentially the same set of proteins are di↵erentially deployed. One of the key places where this is controlled is at the level of transcription which is the first step in protein produc- tion. In this thesis we attempt to shed light on this process by looking at how transcription is regulated in the early Drosophila embryo with a focus on mechanisms of transcriptional precision.
    [Show full text]
  • Brexit and Research: 58 Life Science Good Bye EU Money Researchers Elected and Colleagues? PAGES 4 –5 PAGE 8
    SUMMER 2016 ISSUE 33 EMBO | EMBL Symposium | Tubulin discovery’s 50th anniversary Moving on transient tracks PAGES 12 – 13 © Carsten Janke © Commentary EMBO Members Brexit and research: 58 life science Good bye EU money researchers elected and colleagues? PAGES 4 –5 PAGE 8 EMBO Gold Medal 2016 awarded to Sharing of preprint manuscripts From potential to policy Interview with Richard Benton and Ben Lehner Are biologists ready? Carlos Moedas, European Commissioner for Research, Science and Innovation PAGE 6 PAGE 7 PAGES 10 – 11 www.embo.org Table of contents The EMBO community welcomes Malta and Lithuania Page 2 New EMBO Members 2016 Page 4 Richard Benton and Ben Lehner awarded EMBO Gold Medal Page 6 Are biologists ready for preprints? How transparency in publishing is opening up research Page 7 Brexit and research: Good bye EU money and Editorial colleagues? Commentary ince the creation of EMBO and Page 8 Sits intergovernmental funding body EMBC, the European idea has probably never been questioned How objective can one be? Metrics in research more than in the last few months. assessment With the vote in the UK to leave the Page 9 European Union, European organi- zations will have an important From potential to policy role in showing the value of an a Interview with EU Commissioner Carlos Moedas common and open European space Page 10 – in general, but also for us a scien- © Marietta Schupp, EMBL Photolab Marietta Schupp, © tists in particular. On pages 8 and 9, we publish commentaries from Moving on transient tracks: 50th anniversary of two concerned scientists. EMBO will not directly the discovery of tubulin affected by the UK leaving Europe, as its funding Science story comes from an intergovernmental organization of Page 12 which the UK will remain a member.
    [Show full text]
  • Maria Leptin
    Developmental Biology 451 (2019) 3–4 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/locate/developmentalbiology Q&A single-cell branching – Maria Leptin Sofia J. Araújo a,b a Department of Genetics, Microbiology and Statistics, School of Biology, University of Barcelona, 08028 Barcelona, Spain b Institute of Biomedicine University of Barcelona (IBUB), Spain Maria Leptin works simultaneously in the independent fields of Cologne, just a fun coincidence!), and we found it was also expressed in immunology and embryonic development. She is the director of the the tracheal system. We found ourselves talking to Markus Affolter about European Molecular Biology Organization (EMBO) and runs a laboratory this, whose lab had just identified a deficiency with an interesting mutant in Heidelberg, as well as one in Cologne. Maria Leptin's laboratories phenotype in the tracheal system, and decided to see whether we might study the development of complex cell shapes and the localisation of have landed on the same gene. We had, and this led to an exciting and mRNA and proteins involved in determining the polarity of such cells. A fruitful collaboration to determine its function: an adapter acting major part of the research involves studying the terminal cells in the downstream of the FGF-receptor, which we named Dof, and which turned respiratory system (trachea) of Drosophila during single-cell branching. out to be the product of a gene that had also been found by the Krasnow lab who called it stumps. We then continued to use both the mesoderm and the tracheal system to study the effects of FGF signalling on cell shape, which necessarily eventually led us to branching morphogenesis.
    [Show full text]
  • EMBO's Press Release
    EMBO PRESS RELEASE Embargo: 7 July, 14:00 CET EMBO announces newest elected members Heidelberg, 7 July 2020 - EMBO has bestowed upon 63 leading scientists the lifetime honour of EMBO Membership in recognition of their remarkable achievements in the life sciences, it was announced today. 52 new Members and 11 Associate Members, residing in 25 countries, have been newly elected and join the community of the EMBO Membership. The new Members boast a large range of accomplishments, with candidates elected based on scientific excellence and pioneering research. “The new Members have contributed to the success of research in the life sciences in Europe and around the world,” said EMBO Director Maria Leptin. “As EMBO Members they can help to shape the future through EMBO’s work to support talented researchers, bring ideas together, and promote an international research environment conducive to excellent science.” EMBO Members actively participate in EMBO initiatives, for example by serving on EMBO Council and committees, by mentoring young scientists, or supporting activities such as the promotion of sound science policy. Members also guide and support the organisation in ensuring the highest quality in the selection of future members, postdoctoral fellows, and courses and workshops. The 52 new EMBO Members reside in 18 Member States of the European Molecular Biology Conference (EMBC), EMBO’s intergovernmental funding body. The 11 new Associate Members are currently based in Australia, Canada, Chile, India, Japan, Singapore, and the United States. The new Members carry out research across a broad range of life science disciplines, including neuroscience, plant biology, cell biology, signal transduction, development, molecular medicine, immunology, and many more.
    [Show full text]
  • Research in Brief About EMBL Contents
    2018 Research in brief About EMBL Contents EMBL is Europe’s leading laboratory for the life sciences. We are an 2 About EMBL intergovernmental organisation established in 1974 and are supported by over 20 member states. 4 Careers at EMBL EMBL performs fundamental research in molecular biology, studying the story of life. We offer services to the scientific community; train the next generation of scientists and strive to integrate the life sciences across Europe. 5 Directors’ Research – Heidelberg We are international, innovative and interdisciplinary. We are more than 1700 people, from over 80 countries, operating across six sites in Barcelona (Spain), 6 Cell Biology and Biophysics – Heidelberg Grenoble (France), Hamburg (Germany), Heidelberg (Germany), Hinxton (UK) and Rome (Italy). Our scientists work in independent groups and conduct research and offer services in all areas of molecular biology. 9 Developmental Biology – Heidelberg Our research drives the development of new technology and methods in the life sciences. We work to transfer this knowledge for the benefit of society. 11 Genome Biology – Heidelberg 13 Structural and Computational Biology – Heidelberg 16 Core Facilities – Heidelberg 18 Bioinformatics Research – Hinxton 23 Bioinformatics Services – Hinxton 29 Structural Biology – Grenoble 31 Structural Biology – Hamburg Barcelona Hamburg Heidelberg 33 Epigenetics and Neurobiology – Rome 35 Tissue Biology and Disease Modelling – Barcelona 36 Index Hinxton Grenoble Rome 2 Contents 2 About EMBL 4 Careers at EMBL 5 Directors’ Research – Heidelberg 6 Cell Biology and Biophysics – Heidelberg 9 Developmental Biology – Heidelberg 11 Genome Biology – Heidelberg 13 Structural and Computational Biology – Heidelberg 16 Core Facilities – Heidelberg 18 Bioinformatics Research – Hinxton 23 Bioinformatics Services – Hinxton 29 Structural Biology – Grenoble 31 Structural Biology – Hamburg 33 Epigenetics and Neurobiology – Rome 35 Tissue Biology and Disease Modelling – Barcelona 36 Index Careers at EMBL EMBL is no ordinary place to work.
    [Show full text]
  • Downloaded the Corresponding Sequence
    bioRxiv preprint doi: https://doi.org/10.1101/027151; this version posted September 18, 2015. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Structure and evolutionary history of a large family of NLR 2 proteins in the zebrafish 3 4 5 Kerstin Howe1*, Philipp H. Schiffer2,3*, Julia Zielinski2, Thomas Wiehe2, Gavin K. Laird1, 6 John C. Marioni14, Onuralp Soylemez5,6, Fyodor Kondrashov5,6,7, Maria Leptin2,3# 7 8 1 Wellcome Trust Sanger Institute, Cambridge, United Kingdom 9 2 Institut für Genetik, Universität zu Köln, Köln, Deutschland 10 3 The European Molecular Biology Laboratory, Heidelberg, Germany 11 4 The European Molecular Biology Laboratory, The European Bioinformatics Institute 12 (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom 13 5 Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. 14 Aiguader, 08003 Barcelona, Spain. 15 6 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. 16 7Institució Catalana de Recerca i Estudis Avançats (ICREA), 23 Pg. Lluís Companys, 08010 17 Barcelona, Spain. 18 *Contributed equally 19 Keywords: NACHT, B30.2, SPRY, Pyrin, gene family expansion, gene conversion, innate 20 immune system, genome evolution 21 Running title: Evolution and structure of the NLR-B30.2 family 22 23 [email protected], ORCiD: 0000-0003-2237-513X 24 [email protected], ORCiD: 0000-0001-6776-0934 25 [email protected] 26 [email protected] 27 [email protected], ORCiD: 0000-0003-2294-0135 28 [email protected], ORCiD: 0000-0001-9092-0852 29 [email protected], ORCiD, 0000-0001-8308-6855 30 [email protected] 31 [email protected], ORCiD: 0000-0001-7097-348X 32 33 #corresponding author: 34 Prof.
    [Show full text]
  • EMBO Recognizes 63 Researchers for Advances in Life Sciences
    European Molecular Biology Organization PRESS RELEASE EMBO recognizes 63 researchers for advances in life sciences HEIDELBERG, GERMANY, this yearʼs election work in countries By their involvement with the 27 OCTOBER 2010 – The European across Europe and become EMBO organizationʼs activities, the selected Molecular Biology Organization Members. Fourteen of those elected researchers will help shape the (EMBO) today announced the work in the United States, Japan and direction of the life sciences in recognition of outstanding research Taiwan and are honoured as EMBO Europe. More than half of the EMBO contributions by 63 life scientists Associate Members. International Members contribute by serving on from 14 countries. The researchers mobility has been key for many of advisory editorial boards of the are awarded the life-long honour of the new members and associate organizationʼs four scientific journals, EMBO membership, joining almost members as they progressed in their mentoring young researchers, 1500 of the worldʼs leading scientific careers, fostering providing expertise to EMBO molecular biologists. innovative and collaborative research programmes and taking the lead on “EMBO Members are the basis globally. new initiatives. Members also for the organizationʼs international The 63 scientists represent a nominate candidates for the annual reputation and our most valuable broad cross-section of research EMBO Gold Medal award. asset,” said Maria Leptin, EMBO covering classical areas of molecular A list of the newly elected EMBO Director. “We welcome this yearʼs biology as well as rapidly developing Members and Associate Members group of exceptional scientists and fields such as systems biology, accompanies this announcement. look forward to their fresh input and neuroscience and cancer biology.
    [Show full text]