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The Second Annual London Health Care Conference 20-21 June 2007 INVITED COMPANIES INCLUDE: Abcam plc ABC LN Genmab A/S GEN DC Skyepharma plc SKP LN Acambis plc ACM LN GPC Biotech AG GPC GF Spacelabs Healthcare, Inc. SLAB LN Actelion Ltd ATLN SW Gyrus Group plc GYG LN Speedel Holding AG SPPN SW Alizyme plc AZM LN Human Genome Sciences, Inc HGSI SR Pharma plc SPA LN ALK-Abello A/S ALKB DC Inion Oy IIN LN Stallergenes SA GENP FP Allergy Therapeutics plc AGY LN Innate Pharma SA IPH FP Thrombogenics NV THR BB Alnylam Pharmaceuticals, Inc. ALNY Intercell AG ICLL AV TiGenix NV TIG BB Antisoma plc ASM LN Intercytex Group plc ICX LN Tissue Science Laboratories plc TSL LN Ardana plc ARA LN Jerini AG JI4 GF TopoTarget A/S TOPO DC Ark Therapeutics Group plc AKT LN LifeCycle Pharma A/S LCP DC UCB SA UCB BB Arpida Ltd ARPN SW Lipoxen plc LPX LN plc VEC LN Axis-Shield plc ASD LN Medivance Vernalis plc VER LN Basilea Pharmaceutica AG BSLN SW NeuroSearch A/S NEUR DC Whatman plc WHM LN Bespak plc BPK LN Newron Pharmaceuticals SpA NWRN SW Xcounter AB XCT LN BioAlliance Pharma BIO FP NicOx SA COX FP Zeltia SA ZEL LN Biocompatibles International plc BII LN Oncomethylome Sciences SA ONCOB BB BTG plc BGC LN Optos plc OPTS LN As of 21 March 2007 Celsis International plc CEL LN Oxford Biomedica plc OXB LN Clinphone plc CNP LN Paion AG PA8 GR Corin Group plc CRG LN Pharmexa A/S PHARMX DC Crucell NV CRXL NA Premier Research Group plc PRG LN Curalogic A/S CUR DC ProStrakan Group plc PSK LN Cytos Biotechnology AG CYTN SW Protherics plc PTI LN Entelos Inc ENTL LN Puricore plc PURI LN Evotec OAI AG EVT NM Qiagen NV QIA GR Exelixis, Inc. EXEL Renovo Group plc RNVO LN Galapagos NV GLPG LN Santhera Pharmaceuticals AG SANN SW Genetix Group plc GTX LN Shire PLC SHP LN Genfit ALGFT FP Sinclair Pharma plc SPH LN MARK YOUR CALENDAR

PIPER JAFFRAY London Health Care Conference

Piper Jaffray cordially invites you to attend the Second Annual London Health CONFERENCE FORMAT Care Conference on Wednesday, 20 June 2007 and Thursday, 21 June 2007 Company presentations will be 20 minutes in length, followed by a 40 minute in London. general breakout session. One-on-one meetings will be scheduled pending management availability. We plan to host more than 70 companies from the U.S., UK and continental European biopharmaceutical and medical technology sectors for two full days RECEPTION of presentations and one-on-one meetings. This unique format will provide you Please join us for a cocktail and hors d’oeuvre reception at the conclusion with the opportunity to learn more about growth prospects for the industry, as of the first day of the conference on 20 June 2007 at the hotel. well as to network with other investors from across the globe. HOTEL ACCOMMODATIONS Piper Jaffray has built one of the strongest research, investment banking, and For hotel reservations, please contact Lisa Berlyn at [email protected] sales and trading operations dedicated to the health care industry. We have or by phone during business hours Monday–Friday at +44 (20) 7618 5132 and served as financial advisor and/or broker to 40 percent of companies in the reference “Piper Jaffray” to secure accommodations with a valid credit card for techMARK Mediscience Index, and believe that, in combination with our top- this event at the negotiated rate of £275 + VAT at 17.5% ($531 approx.+ tax) per rated position in the U.S. health care industry this uniquely positions us to room per night. Reservations are based on availability until the cut-off date of serve the needs of companies and investors alike. 4 June 2007. We recommend making reservations early due to strong demand.

DATE REGISTRATION Wednesday, 20 June–Thursday, 21 June 2007 To register online, please visit www.piperjaffray.com/lhc. U.S. contact information: MEETING LOCATION Questions? Contact the conference information line at 800 333-6000, The Great Eastern Hotel ext. 36074, or e-mail [email protected]. Corner of Liverpool Street & Bishopsgate London EC2M 7QN European contact information: +44 (20) 7618 5010 Claire Dumper www.great-eastern-hotel.co.uk +44 (20) 3142 8726 [email protected]

ATTIRE Business attire is appropriate. Securities products and services offered in the United Kingdom by Piper Jaffray Ltd, registered in England, no. 3846990, and its registered office is 7 Pilgrim St, London EC4V 6LB. Piper Jaffray Ltd. is authorised and regulated by the Financial Services Authority, entered on the FSA's register no.191657 and is a member of the . © 2007 Piper Jaffray & Co. 3/07 CM-07-1025 piperjaffray.com