Chromatin State Barriers Enforce an Irreversible Mammalian Cell Fate Decision
bioRxiv preprint doi: https://doi.org/10.1101/2021.05.12.443709; this version posted May 14, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Chromatin state barriers… Blanco et al. 2021 Chromatin state barriers enforce an irreversible mammalian cell fate decision M. Andrés Blanco1,19,*,†,, David B. Sykes6,8,19, Lei Gu2,15,17,18,19, Mengjun Wu2,4,15, Ricardo Petroni1, Rahul Karnik7,8,9, Mathias Wawer10, Joshua Rico1, Haitao Li1, William D. Jacobus2,12,15, Ashwini Jambhekar2,15,11, Sihem Cheloufi5, Alexander Meissner7,8,9,13, Konrad Hochedlinger6,7,8,14, David T. Scadden6,8,9,*, and Yang Shi2,3,* 1 Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA 2 Division of Newborn Medicine, Boston Children’s Hospital, Boston, MA 02115, USA 3 Ludwig Institute for Cancer Research, Oxford Branch, Oxford University, UK 4 Current address: The Bioinformatics Centre, Department of Biology and Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark 5 Department of Biochemistry, Stem Cell Center, University of California, Riverside, Riverside, CA 92521, USA. 6 Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA. 7 Broad Institute of MIT and Harvard, Cambridge, MA, USA 8 Harvard Stem Cell Institute, Cambridge, Massachusetts,
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