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ISNR) NEURAL REGENERATION (ISNR) NEURAL REGENERATION (ISNR) Dr 14th INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION (ISNR) Dr. Roger Madison, Director December 7th-11th, 2011 Asilomar Conference Center Pacific Grove, CA USA Hosted by: International Symposium on Neural Regeneration U.S. Department of Veterans Affairs (Biomedical Laboratory Research and Development Service) (Office of Research and Development) Cosponsored by: National Institutes of Health (National Institute of Neurological Disorders and Stroke) California Institute for Regenerative Medicine (CIRM) Paralyzed Veterans of America (Education Foundation) International Society for Neurochemistry (ISN) Mission Connect – A Project of TIRR Foundation Information about the symposia series can be obtained from the conference Web site (www.rehab.research.va.gov/ISNR), from the directors office via email: [email protected], or by calling (919) 286-0411 x7691. 1 2 THE FOURTEENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION December 7-11, 2011 Asilomar Conference Grounds Phone: (813) 642-4222 800 Asilomar Boulevard Fax: (813) 642-4261 Pacific Grove, California 93950 Web: www.visitasilomar.com SYMPOSIUM DIRECTOR Roger D. Madison (VA Medical Center and Duke University – Durham, NC) PROGRAM PLANNING COMMITTEE Jacqueline Bresnahan (University of California, San Francisco, CA) David Gardiner (University of California, Irvine, CA) James Guest (University of Miami – Miami, FL) Jane Lebkowski (Geron Corporation, Menlo Park, CA) David Shine (Baylor College of Medicine/Houston VA Medical Center – Houston, TX) John Steeves (ICORD/University of British Columbia – Vancouver, BC, Canada) Guest Participants: Audrey Kusiak (VA Rehabilitation Research and Development – Washington, DC) Naomi Kleitman (NIH/National Institute of Neurological Disorders and Stroke – Bethesda, MD) PROGRAM AND TECHNICAL ASSISTANTS Frances Stuart (VA Medical Center – Durham, NC) Qiang Li (VA Medical Center and Duke University – Durham, NC) Chris McGee (VA Medical Center – Durham, NC) Rod Williams (International Symposium on Neural Regeneration) ACKNOWLEDGEMENTS The symposium is sponsored by the US Department of Veterans Affairs (Biomedical Laboratory Research and Development Service, Office of Research and Development), the Paralyzed Veterans of America (Education Foundation), the National Institutes of Health (National Institute of Neurological Disorders and Stroke), California Institute for Regenerative Medicine, International Society for Neurochemistry and Mission Connect (A Project of TIRR Foundation). 3 INTRODUCTION The Fourteenth International Symposium on Neural Regeneration will be held at the Asilomar Conference Center in Pacific Grove, California from December 7-11, 2011. The International Symposium on Neural Regeneration began in 1985, and has been held on a biennial basis since that time. The primary sponsor has been the Department of Veterans Affairs, with the NIH continuously co-sponsoring the symposia since 1987. Long term generous support has also been given by the Paralyzed Veterans of America. Current ISNR funding has also been received from the California Institute for Regenerative Medicine, the International Society for Neurochemistry and Mission Connect, which is a project of TIRR Foundation. The generous support of all of our sponsors is gratefully acknowledged. The keynote speakers for this year’s symposium will be Mark Tuszynski from the University of California, San Diego and the San Diego VA Medical Center. Featured talks will be given by Hunter Peckham from Case Western Reserve University and the Cleveland VA Medical Center; Colin McCaig from the University of Aberdeen; Dwight Bergles from the Johns Hopkins School of Medicine; Stefan Heller from Stanford University School of Medicine and Ed Boyden from Massachusetts Institute of Technology. Following the format of preceding neural regeneration symposia, the program is divided into six sessions, including: 1) Brain Machine Interface, chaired by Doug Weber; 2) DEBATE – The future of functional recovery is robotics not regeneration, moderated by Dave Shine; 3) Stem Cells – The promises and challenges, chaired by Itzhak Fischer; 4) Translational Approaches, chaired by Naomi Kleitman; 5) ISN Symposium on Neurochemistry and Neurobiology of Repair, chaired by Jacqueline Bresnahan; and 6) Route 28 Summit Presentations – Novel ways to exploit stem cells for recovery of CNS function, chaired by Theo Palmer. The abstracts for the speaker presentations as well as 87 poster presentations are given in the program on the following pages. The primary purpose of the symposium is to present current work in neural regeneration, especially in those areas of research in which there has been some notable recent progress or in which some particularly interesting issues have been raised. A secondary purpose is to foster an atmosphere that is both stimulating and conducive to a free interchange of ideas among investigators, or between seasoned investigators and students. The International Neural Regeneration Symposium has become an established, regularly occurring event with high attendance by both students as well as internationally recognized experts in the field of neural regeneration. Roger Madison,, Ph.D. Director, International Symposium on Neural Regeneration Laboratory of Nerve Regeneration Duke University Medical Center Research Career Scientist Veterans Affairs Medical Center Building/16/Room 38 508 Fulton Street Durham, NC 27705 4 TABLE OF CONTENTS Host and Sponsors…………………………………………………………………… 1 Committee and Acknowledgements………………………………………………… 3 Introduction: Fourteenth International Symposium on Neural Regeneration………. 4 Scientific Program……………………………………………………………….….. 7 Oral Presentations……………………………………………………………………13 Overview - Poster Presentations………………………………………………….….25 Abstracts of Poster Presentations – Session One………………………………….…34 Abstracts of Poster Presentations – Session Two……………………………….…...64 Author Index……………………………………………………………………..…..90 5 6 14th International Symposium on Neural Regeneration Scientific Program WEDNESDAY – DECEMBER 7, 2011 3:00 PM Arrival of participants and check-in 6:00 PM DINNER 7:30 PM Welcome and Keynote Address Keynote Speaker: Mark Tuszynski University of California, San Diego San Diego VAMC San Diego, CA - USA “Combinatorial Strategies for Regeneration After Spinal Cord Injury” THURSDAY – DECEMBER 8, 2011 Session One: 8:15 am Brain Machine Interface (BMI) 8:15 AM Chair: Doug Weber University of Pittsburgh Pittsburgh VAMC Pittsburgh, PA - USA 8:30 AM Andrea Kubler University of Wurzburg Germany “Out of the frying pan into the fire – BCI faces real world application” 9:00 AM Bradley Greger University of Utah Salt Lake City, UT - USA “Micro-electrodes in and on the cerebral cortex for decoding and encoding information” 9:30 AM Chet Moritz University of Washington Seattle, WA - USA “Leveraging neural plasticity for the treatment of paralysis and other movement disorders” FOURTEENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION 7 10:00 AM Jennifer Collinger University of Pittsburgh Pittsburgh VAMC Pittsburgh, PA - USA “Is BCI technology ready for prime time? The science is mature and the consumers are willing - what are we waiting for?” 11:00 AM Featured Speaker Hunter Peckham Case Western Reserve University Cleveland VAMC Cleveland, OH - USA “The Role of Neural Prosthesis and Neural Stimulation In the Restoration of Function” 12:00 Noon LUNCH 1:00 PM Featured Speaker Colin McCaig University of Aberdeen Scotland “Regulating neural cell behaviour with extracellular electrical signals” 2:00 PM Viewing: Poster Session 1 6:00 PM DINNER Session Two: 7:15 PM – 9:00 PM (or beyond) DEBATE – Proposition: The future of functional recovery is robotics not regeneration 7:15 PM Moderator: Dave Shine Baylor College of Medicine Houston VAMC Houston, TX - USA Affirmative: Vivian Mushahwar University of Alberta Edmonton, Alberta, Canada Chet Moritz University of Washington Seattle, WA - USA Doug Weber University of Pittsburgh 8 FOURTEENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION Pittsburgh VAMC Pittsburgh, PA - USA Alan Harvey University of Western Australia Crawley, Western Australia Negative: Hunter Peckham Case Western Reserve University Cleveland VAMC Cleveland, OH - USA Linda Noble-Hauesslein University of California, San Francisco San Francisco, CA - USA Jerry Silver Case Western Reserve University Cleveland, OH - USA Arthur Prochazka University of Alberta Edmonton, Alberta, Canada FRIDAY – DECEMBER 9, 2011 Session Three: 8:15 AM Stem Cells – The promises and challenges 8:15 AM Chair: Itzhak Fischer Drexel University Philadelphia, PA - USA 8:30 AM Mathew Blurton-Jones University of California, Irvine Irvine, CA - USA “Can Neural Stem Cells be used to treat Alzheimer disease?” 9:00 AM Itzhak Fischer Drexel University Philadelphia, PA - USA “Transplanting neural stem cells to reconnect the injured spinal cord” 9:30 AM Nicholas Maragakis Johns Hopkins School of Medicine Baltimore, MD - USA FOURTEENTH INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION 9 “Scientific and Clinical Challenges in using Stem Cells for Investigating and Treating Amyotrophic Lateral Sclerosis” 10:00 AM Gary Steinberg Stanford University School of Medicine Stanford, CA - USA “Neural Stem Cell Therapy for Stroke: Underlying Mechanisms and Clinical Translation” 10:30 AM BREAK 11:00 AM Featured Speaker Dwight Bergles Johns Hopkins School of Medicine Baltimore, MD - USA “Fate and function of glial progenitors in the mammalian CNS” 12:00 Noon LUNCH 1:00 PM Featured Speaker Stefan Heller Stanford University School of Medicine
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