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UNITED NATIONS RC UNEP/FAO/RC/CRC.7/9/Add.1 Rotterdam Convention on the Prior Distr.: General 20 December 2010 Informed Consent Procedure for Certain Hazardous Chemicals and English only Pesticides in International Trade Chemical Review Committee Seventh meeting Rome, 28 March–1 April 2011 Item 4 (c) (vi) of the provisional agenda∗ Technical work: review of notifications of final regulatory action: pentachlorobenzene Pentachlorobenzene Note by the Secretariat Addendum Supporting documentation provided by Canada The Secretariat has the honour to provide, in the annex to the present note, documentation received from Canada to support its notification of final regulatory action for pentachlorobenzene as an industrial chemical. The documentation has not been formally edited. ∗ UNEP/FAO/RC/CRC.7/1. K1063386 280111 UNEP/FAO/RC/CRC.7/9/Add.1 Annex ____________________ 2 ChemBioFinder.Com- - Structure Details Page 1 of 1 CambridgeSoft.com ChemBioNews.com ChemBioFinder.com SciStore.com Login Register Reference Chemicals Reactions Software About Help Contact Home Record 1 of 1 New Query Return to List Molecular Profile Report Resources View Record Content Type Source Database Key Subscribe Reference ChemIndex (CI) 608-93-5 Subscribe Reference National Cancer Institute (NCI) 1857 View Record Reference NetProtm Molecular Connections (NETPRO) MC50882 Subscribe Safety Sigma Aldrich MSDS (SAMSDS) X1003313-5 Subscribe Sourcing ChemACX (ACX) X1003313-5 Names and Synonyms Names Sources 1,2,3,4,5-Pentachlorobenzene CHEMACX CHEMINDEX NCI NETPRO Benzene, pentachloro- (8CI9CI) NCI Pentachlorobenzene CHEMACX CHEMINDEX NCI SA-MSDS QCB CHEMACX CHEMINDEX NCI WLN: GR BG CG DG EG NCI Identifiers Chemical Identifiers Type Sources X1003313-5 acx_id SA-MSDS CHEMACX 608-93-5 casrn CHEMACX CHEMINDEX NETPRO NCI SA-MSDS MC50882 int_id NETPRO 608-93-5 mol_rel_id CHEMACX CHEMINDEX NETPRO NCI SA-MSDS 1857 nsc NCI Properites Type Value Source Formula C6HCl5 CSCARTRIDGE MW 250.3371 CSCARTRIDGE SMILES ClC1=CC(Cl)=C(Cl)C(Cl)=C1Cl CSCARTRIDGE Std. InChI InChI=1S/C6HCl5/c7-2-1-3(8)5(10)6(11)4(2)9/h1H CSCARTRIDGE Std. InChIKey CEOCDNVZRAIOQZ-UHFFFAOYSA-N CSCARTRIDGE ChemBioFinder.Com Gateway version 3.0 CambridgeSoft.com ChemBioNews.com ChemBioFinder.com SciStore.com America 1 800 315-7300 Europe 00 800 875-20000 Germany 49 69 2222 2280 France 33 1 70 71 98 80 Japan 0120 146 700 All trademarks are the property of their respective holders. © 2010 CambridgeSoft Corporation. All Rights Reserved. Privacy Statement http://www.chemfinder.com/chembiofinder/Forms/Search/ContentArea/ChemBioVizSear... 12/17/2010 ROTTERDAM CONVENTION SECRETARIAT FOR THE ROTTERDAM CONVENTION ON THE PRIOR INFORMED CONSENT PROCEDURE FOR CERTAIN HAZARDOUS CHEMICALS AND PESTICIDES IN INTERNATIONAL TRADE Food and Agriculture United Nations Environment Organization of the United Programme (UNEP) Nations (FAO) 11-13, Chemin des Anémones Viale delle Terme di Caracalla CH – 1219 Châtelaine 00100 Rome, Italy Geneva, Switzerland Tel: (+39 06) 5705 2188 Tel: (+41 22) 917 8296 www.pic.int Fax: (+39 06) 5705 6347 Fax: (+41 22) 917 8082 E-mail: [email protected] E-mail: [email protected] Geneva, 17 December 2010 Subject: PIC procedure – Your submission of notifications of Final Regulatory Action Dear Mr. Madé, We are pleased to inform you that the Secretariat has now received two verified notifications from two different PIC regions for: Pentachlorobenzene This chemical will now also be sent to the Chemical Review Committee for review and for possible recommendation to the Conference of the Parties for inclusion in Annex III. To support the work of the Chemical Review Committee at its 7th meeting, we would like to kindly request that you provide the supporting documentation referenced in the notification you have submitted on 28 August 2008, which has been published in the 28th PIC Circular. Documentation referenced in the notifications is outlined below. Please also submit, if available, any other information that was used in the analysis for the decision as those may have been used for section 2.4.2.2. which may not have been included below: Documentation referenced in the notifications Pentachlorobenzene - Prohibition of Certain Toxic Substances Regulations, 2005 (SOR/2005-41) under the Canadian Environmental Protection Act, 1999. - Regulations Amending the Prohibition of Certain Toxic Substances Regulations, 2005 (2- Methoxyethanol, Pentachlorobenzene and Tetrachlorobenzenes), 2006 (SOR/2006-279) under the Canadian Environmental Protection Act, 1999. Mr. Bernard Madé Director, Chemical Production Environment Canada 351 St. Joseph Blvd, 17th Floor Gatineau, Quebec K1A 0H3 Canada Secretariat for the Rotterdam Convention Page 2 - Follow-up Report on Five PSL 1 Substances for Which There Was Insufficient Information to Conclude Whether the Substances Constitute a Danger to the Environment: 1,2- Dichlorobenzene; 1, 4-Dichlorobenzene; Trichlorobenzenes; Tetrachlorobenzenes; Pentachlorobenzene (2003). - Risk Management Strategy for Pentachlorobenzene (QCB) and tetrachlorobenzenes (TeCBs). Chemical Control Branch. Environmental Protection Services. June 2005. - Canadian Environmental Protection Act Priority Substances List Assessment Report: Pentachlorobenzene (1993). - ChemFinder.com Database and Internet Searching (www.chemfinder.com). - Groundwater Services, Inc. Chemical properties database (www.gsi-net.com). - IPCS INCHEM; Concise International Chemical Assessment Document 60; Chlorobenzenes other than hexaclorobenzene: Environmental Aspects (www.inchem.org) In addition to the above and in line with the process for collecting information on ongoing international trade, we kindly request you to provide, where available, information on whether or not Pentachlorobenzene was manufactured in Canada and, if so, whether it is being exported. You are further requested to provide, if available, the date on which this chemical was last imported into Canada. The documentation should be provided preferably in English or at least, with a focused summary in English. Please submit this information on or before 12 January 2011. Should you require assistance in compiling this information, or have questions regarding the submission of additional information, please do not hesitate to contact the Secretariat by sending your inquiry to Ms. Neslihan Grasser, Scientific Affairs Officer (e-mail: [email protected]). We would like to take this opportunity to express our gratitude to Canada for your continued support to the work of the Chemical Review Committee. Yours sincerely, Donald Cooper Co-Executive Secretary Canadian Environmental Protection Act Priority Substances List Assessment Report Pentachlorobenzene Government Gouvernement of Canada du Canada Environment Environnement Canada Canada Health Santé Canada Canada Canada CANADA'S GREEN PLAN Canadian Environmental Protection Act Priority Substances List Assessment Report Pentachlorobenzene Government of Canada Environment Canada Health Canada Aussi disponible en français sous le titre de: Loi canadienne sur la protection de 1’environnement Liste des substances d’intérêt prioritaire Rapport d’évaluation: Pentachlorobenzène CANADIAN CATALOGUING IN PUBLICATION DATA Main entry under title: Pentachlorobenzene (Priority substances list assessment report) Issued also in French under title: Pentachlorobenzène. At head of title: Canadian Environmental Protection Act Includes bibliographical references. ISBN 0-662-21064-6 Cat. No. En40-215/26E 1. Pentachlorobenzene - Environmental aspects. 2. Pentachlorobenzene - Toxicity testing. 3. Environmental monitoring - Canada. I. Canada. Environment Canada. II. Canada. Health Canada. III. Series. TD427.P32P56 1993 363.73'84 C94-980029-5 Canada Groupe Communication Communication Group Canada Publishing Edition © Minister of Supply and Services Canada 1993 Canada Communication Group - Publishing Ottawa, Canada K 1A 0S9 Cat. No. En40-215/26E ISBN 0-662-21064-6 Printed on recycled paper Pentachlorobenzene Table of Contents Synopsis .................................................................................................................................v 1.0 Introduction..............................................................................................................1 2.0 Summary of Information Critical to Assessment of "Toxic"...............................4 2.1 Identity, Properties, Production and Uses ..................................................................4 2.2 Entry into the Environment ........................................................................................5 2.3 Exposure-related Information.....................................................................................7 2.3.1 Fate .................................................................................................................7 2.3.2 Concentrations................................................................................................8 2.4 Effects-related Information ......................................................................................12 2.4.1 Experimental Animals and In Vitro .............................................................12 2.4.2 Humans.........................................................................................................15 2.4.3 Ecotoxicology...............................................................................................15 3.0 Assessment of "Toxic" under CEPA....................................................................16 3.1 CEPA 11(a): Environment .......................................................................................16
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