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Atlas of Immunology THIRD EDITION K10141_C000.indd 1 3/26/10 11:06:20 AM K10141_C000.indd 2 3/26/10 11:06:20 AM THIRD EDITION Julius M. Cruse, B.A., B.S., D.Med.Sc., M.D., Ph.D., Dr. h.c., F.A.A.M., F.R.S.H., F.R.S.M Professor of Pathology, Vice Chair, Department of Pathology Director of Anatomic Pathology Director of Immunopathology and Transplantation Immunology Director of Graduate Studies in Pathology Professor of Medicine and Professor of Microbiology Distinguished Professor of the History of Medicine University of Mississippi Medical Center Jackson, Mississippi Robert E. Lewis, B.S., M.S., Ph.D., F.R.S.H., F.R.S.M. Professor of Pathology Director of Immunopathology and Transplantation Immunology Department of Pathology University of Mississippi Medical Center Jackson, Mississippi Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business K10141_C000.indd 3 3/26/10 11:06:21 AM CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2010 by Taylor and Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-13: 978-1-4398-0269-4 (Ebook-PDF) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Dedicated in Celebration of the Election of the 16th Chancellor of the University of Mississippi Whose life and work is guided by selfless dedication to our university, state, and nation. A gifted educator and administrator with a clear vision for the university’s future, Dr. Jones is the quintessential representative of what is and has always been the very best of America. Steadfast always for social and moral justice, he is truly “a man for all seasons.” K10141_C000d.indd 5 3/25/10 9:47:39 AM Editorial Staff Jeanann Lovell Suggs, Ph.D. (M.D. candidate) Bradley J. Suggs, M.D. Coordinating Editor Contributing Editor Venkat K.R. Mannam, M.B.B.S (Ph.D. candidate) Will Singleterry (Ph.D. candidate) Managing Editor, Co-author of Chapter 18, and Contributing Editor Lexicographic Researcher Joshua Ryan Goodin, B.S., B.S.N., R.N., H.T. (ASCP) G. Reid Bishop, B.S., Ph.D. (M.S.N. candidate) Formerly Assistant Professor of Chemistry Contributing Editor Mississippi College Silicon Graphics Molecular Models Julia C. Peteet Illustrator Principal Transcriptionist Melissa Howard (M.D. candidate) Principal Transcriptionist CRC Press Editorial Staff Barbara Ellen Norwitz Jonathan Pennell Executive Editor Art Director Pat Roberson Pamela Morrell Production Coordinator Prepress Manager Amy Rodriguez Project Editor K10141.indb 6 3/22/10 5:57:28 PM Authors Julius M. Cruse, B.A., B.S., and has directed dissertation and thesis research for more D.Med.Sc., M.D., Ph.D., than 50 graduate students during his career. He is author or Dr.h.c., is a Guyton Distin- editor of the international journals Immunologic Research, guished Professor, Professor Experimental and Molecular Pathology, and Transgenics. of Pathology, Director of He was chief editor of the journal Pathobiology from 1982 to Immunopathology and Trans- 1998 and was founder of Immunologic Research, Transgenics, plantation Immunology, Director and Pathobiology. of Anatomic Pathology, Vice- Robert E. Lewis, B.A., Chair Department of Pathology, M.S., Ph.D., is Professor Director of Graduate Studies in of Pathology and Director Pathology, Professor of Medicine, of Immunopathology and Professor of Microbiology, and Transplantation Immunology Distinguished Professor of the in the Department of Pathology History of Medicine at the University of Mississippi Medical at the University of Mississippi Center in Jackson. Formerly, Dr. Cruse was Professor of Center in Jackson. Dr. Lewis Immunology and of Biology in the University of Mississippi received his B.A. and M.S. Graduate School. Dr. Cruse graduated in 1958, earning B.A. degrees in microbiology from and B.S. degrees in chemistry with honors from the University the University of Mississippi of Mississippi. He was a Fulbright Fellow in the University of and earned his Ph.D. in pathol- Graz (Austria) medical faculty, where he wrote a thesis on ogy (immunopathology) from Russian tickborne encephalitis virus and received a D.Med.Sc. the University of Mississippi degree summa cum laude in 1960. On his return to the United Medical Center. Following States, he entered the M.D./Ph.D. program at the University specialty postdoctoral training at several medical institutions, of Tennessee College of Medicine, Memphis, completing Dr. Lewis has risen through the academic ranks from instructor his M.D. degree in 1964 and Ph.D. in pathology (immu- to professor at the University of Mississippi Medical Center. nopathology) in 1966. Dr. Cruse also trained in pathology at Dr. Lewis is a member of numerous professional societies, the University of Tennessee Center for the Health Sciences, including the American Association of Immunologists, the Memphis, where he was a USPHS Postdoctoral Fellow. American Society for Investigative Pathology, the Society for Dr. Cruse is a member of numerous professional societies, Experimental Biology and Medicine, the American Society including the American Association of Immunologists (his- for Microbiology, the Canadian Society for Immunology, torian), the American Society for Investigative Pathology, the and the American Society for Histocompatibility and American Society for Histocompatibility and Immunogenetics Immunogenetics (chairman, Publications Committee; mem- (historian; member of council, 1997–1999; formerly chair- ber of Board of Directors), among numerous others. He is a man, Publications Committee [1987–1995]), the Societé Fellow of the Royal Society of Health of Great Britain and a Francaise d’Immunologie, the Transplantation Society, and Fellow of the Royal Society of Medicine (U.K.). Dr. Lewis has the Society for Experimental Biology and Medicine, among been the recipient of a number of research grants in his career, many others. He is a Fellow of the American Academy of including 12 years of support funded by the Wilson Research Microbiology, a Fellow of the Royal Society of Health (U.K.) Foundation for his research on neuroendocrine–immune sys- and a Fellow of the Royal Society of Medicine (London). He tem interaction in patients with spinal cord injuries. received the Doctor of Divinity, honoris causa, in 1999 from Dr. Lewis has authored or coauthored more than 150 The General Theological Seminary of the Episcopal Church, papers and 150 abstracts and has made numerous scientific New York City. presentations at both the national and international levels. In Dr. Cruse’s research has centered on transplantation and addition to neuroendocrine–immune interactions, his current tumor immunology, autoimmunity, MHC genetics in the research includes MHC genetics and disease associations pathogenesis of AIDS, and neuroendocrine immune interac- and immunogenetic aspects of AIDS progression. Dr. Lewis tions. He has received many research grants during his career, is a founder, senior editor, and deputy editor-in-chief of including 12 years of support from the Wilson Research Immunologic Research and Transgenics, and is senior editor Foundation for neuroendocrine–immune system interactions and deputy editor-in-chief of Experimental and Molecular in patients with spinal cord injuries. He is the author of more Pathology. He was senior editor and deputy editor-in-chief of than 300 publications in scholarly journals and 45 books, Pathobiology from 1982 to 1998. K10141.indb 7 3/22/10 5:57:29 PM K10141.indb 8 3/22/10 5:57:29 PM Preface The splendid reception of the first and second editions of to refer to another source. The subject matter ranges from this book convinced both the authors and the publisher to photographs of historical figures to molecular structures prepare a third edition. The 11 years since this atlas first of recently characterized cell receptors, chemokines and appeared have witnessed an exponential increase in immu- cytokines, the major histocompatibility complex molecules, nological information emanating from more than 130 jour- immunoglobulins, hematopoietic cells in leukemia, and nals devoted to the subject. The Journal of Immunology molecules of related interest to immunologists.
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