Top University in the UK for the quality of our Biological Sciences research Research Excellence Framework 2014
Life Sciences at the University of Dundee
Welcome lifesci.dundee.ac.uk 1 We’re We’re 2 and one of the and one of 1 Times Higher Education 2020 Times Higher Education Research Excellence Framework 2014 Framework Excellence Research 1 2 world’s top 250 universities. top world’s located in Scotland’s fourth-largest fourth-largest in Scotland’s located city, Dundee, on the picturesque Tay. the River of banks reputation Our international in both teaching excellence for top-class attracts and research and academics from students 145 – over world the all over in our represented are countries community. University future-focused a progressive, We’re aim to we institution, where locally and globally, lives, transform sharing and the creation, through knowledge. of application The University of Dundee is one of Dundee The University Life for leading universities the of Sciences research Law Hill, Dundee Law Welcome lifesci.dundee.ac.uk 3
Professor Julian Blow, Julian Blow, Professor Sciences Life Dean of , or by contacting contacting , or by lifesci.dundee.ac.uk The University The University and teaching: Learning – the highest a Gold award has been given – in the 2017 Teaching possible rating (TEF) Framework Excellence the world’s are We and translation: Impact institution in research most influential Analytics 2017) pharmaceuticals (Clarivate FRSE FMedSci, FRSE → → our School. of an overview gives This brochure on our can be found information Further website, the back cover. using the details on us directly provide outstanding laboratory and outstanding laboratory provide facilities technology and encourage interdisciplinary actively research translational instilling the highest to committed are integrity professional of standards and support equality, diversity inclusivity initiatives development career excellent offer opportunities the top-rated are We Research: of for the quality in the UK University according in Biological Sciences, research research national the most recent to (Research exercise assessment 2014) Framework Excellence To support our staff and students so that so that support our staff and students To we: their ability the best of to can work they → → → → → can be our strategy The success of but examples ways, in many demonstrated core succeeded in our 3 key have we how of are: areas → Carnelley Building Carnelley
Life Sciences Building
Clarivate Analytics 2017 Clarivate in the World in influencing pharmaceuticals →
1 No.
University in the UK University research of quality for in Biological Sciences 2014 Framework Excellence → Research 1 No. There have been huge advances in Life Sciences over the last few decades. decades. the last few Sciences over been huge advances in Life have There our staff and it is crucial for that believe we these changes, adapt to To This disciplinary boundaries. fluidly across work be able to to students with all the basic biological in our structure, is reflected philosophy encourage To complex. in our main research disciplines housed together a collegiate promote we all our staff and students, between interactions in our staff and students value the diversity We together. working of culture than 50 more from academics and scientists about 700 home to and are our success. to essential - it is these people who are countries Welcome of proud are Sciences we Life the School of At the leading as one of reputation our international This reputation in Europe. institutes research in our endeavours through has been gained and teaching, learning research, areas: core three and translation. and impact 2 Research Excellence Excellence Research
Research Excellence
6 Research in the School of Life Sciences
→ Outstanding interdisciplinary research lifesci.dundee.ac.uk → Collaboration is key → High quality infrastructure → Investment in our people 8 History of Life Sciences 10 Overview of our Centres, Divisions and Units → Biological Chemistry and Drug Discovery → Cell and Developmental Biology → Cell Signalling and Immunology → Computational Biology → D'Arcy Thompson Unit → Drug Discovery Unit → Gene Regulation and Expression → Geomicrobiology Group → Medical Research Council Protein Phosphorylation and Ubiquitylation Unit → Nucleic Acid Structure Research Group → Molecular Microbiology → Plant Sciences → Wellcome Centre for Anti-Infectives Research
4 5 Research Excellence Life Sciences Building
Research in the lifesci.dundee.ac.uk School of Life Sciences
Our research involves studying the molecular and cellular mechanisms underlying human health and disease. This has global impact and has been recognised in metrics of scientific excellence that place the University of Dundee high in its rankings. To continue as a world leading institution, we focus on our research and teaching excellence, environment and people.
Outstanding interdisciplinary research Collaboration is key
We support and promote outstanding life To achieve research success, scientists science research. Our expertise spans working on similar topics are grouped together from drug discovery to plant sciences and into our different centres, divisions and units. gene regulation to computational biology. We actively encourage interactions between Interdisciplinarity and translation play key research groups within and across divisions. In roles in our work, which has led to major addition to working together within the School clinical and environmental impact. Our and University, we also see our academic work research is strengthened by mutually as an international enterprise. We collaborate beneficial partnerships with key funding every day with colleagues at institutions agencies, industry and academic institutes around the world. Our view is that these High quality infrastructure Investment in our people in the UK and beyond. collaborations work best bottom-up, driven by shared interests and then supported at Excellent research requires high-quality People are central to our success. The institutional level. facilities, services and physical infrastructure. diversity in our staff and students enhances We have invested substantially, and continue our environment and how we approach our to do so, to maintain such an environment for work. To allow everyone in the School to work our staff and students. This supports them to to the best of their ability, we are committed Postgraduate students in the Discovery Centre ‘Street’ deliver significant progress in the translation to the highest standards of professional of our research to address national and global integrity and strive to provide a supportive health challenges. work environment. We uphold exemplary standards in recruitment and development of all categories of staff, underpinned by equality, diversity and inclusivity initiatives that align with the Athena SWAN charter. The School of Life Sciences is a proud recipient of an Athena SWAN Silver Award.
The Institutional Strategic Support Fund (ISSF) award to the University by Wellcome further supports many of these strategic activities.
No. Top in the UK in the World for influencing for impact of innovation scientific research 1→ Nature Index 2017 5 → CWTS Leiden Rankings 2019
6 7 Research Excellence lifesci.dundee.ac.uk 9 2018 First human clinical trials human First commence for the malaria commence for by Ian Gilbert and colleagues in by that was discovered was discovered compound that malaria patients in a single dose. in a single malaria patients the Drug Discovery Unit. This new Unit. This new the Drug Discovery compound has the potential to treat treat to compound has the potential The newest building of the building of The newest opens. Sciences complex Life for Centre The Discovery and Translational Interdisciplinary brings Research biology with chemistry, together science. and computer physics, 2014 2016 directorship of Paul Wyatt. Paul Wyatt. of directorship under the Research Infectives Centre for Anti- for establish the Centre to s Wellcome awards £13.6m to Dundee £13.6m to awards Wellcome The expansion of scientific research in the research scientific of The expansion appointments School with multiple key activity research further strengthened were These efforts in the University. in Dundee being named top reflected of our for the quality in the UK University (Research Biological Sciences research 2014). Framework Excellence 2000 2006 Drug Discovery Unit is → The Drug Discovery Chagas' disease and malaria). trypanosomiasis, leishmaniasis, leishmaniasis, trypanosomiasis, FRS and Alan Fairlamb CBE to fill fill CBE to and Alan Fairlamb FRS opens. → Sir James Black Centre formed by Sir Mike Ferguson CBE Ferguson Sir Mike by formed the void in the discovery of drugs drugs of in the discovery the void for tropical diseases (human African diseases (human African tropical for 8 Therapy Signal Transduction The Division of and Sir Pete FRS Sir Philip Cohen established by standing the longest of OBE. It is one Downes the pharmaceutical between collaborations industry and an academic institute. Building opens. Trust The Wellcome → → 199 s 2000 the BBSRC Innovator of the Year. the Year. of Innovator the BBSRC programme developing an image- developing programme , geared to the needs of the needs of to , geared Environment Jason Swedlow embarks on a research on a research embarks Jason Swedlow Irwin McLean FRS, Birgit Birgit FRS, Irwin McLean Lane and colleagues time, the the first for show, gene keratin linkage of with several mutations skin disorders. severe 1990 Open Microscopy Open Microscopy system, management quantitative microscopy. In 2011, he wins microscopy. quantitative MRC Protein Phosphorylation Protein The MRC and Sir Unit was established by Ubiquitylation and continues as Director Philip Cohen FRS Dario Alessi FRS. of under the leadership today research kinase profiling The Unit pioneered new of the development transformed that the be at to It continues therapeutic drugs. and phosphorylation protein of forefront research. ubiquitylation 1990 Grahame Hardie Grahame Hardie defines the key FRS sensor cellular energy called AMP-activated kinase protein the first , for (AMPK) time. Pharma will later launch significant drug development campaigns in diabetes and cancer in relation AMPK. of regulation to 1987 1990 to cancer research in 2000. cancer research to Dundee to continue work on work continue Dundee to moves to to moves Lane FRS Sir David p53. He is knighted for services for p53. He is knighted s is appointed as Garland CBE is appointed Peter Biochemistry. Chair of the first New purpose-built facilities, purpose-built facilities, New Medical and Biological Sciences open. Institutes → → 1970 s 1980 structure and folding of of and folding on the structure Pioneering research by David Lilley Lilley David by Pioneering research FRS branched structures of DNA, begins of branched structures nucleic acids, including specialised in Dundee and continues to this day. to in Dundee and continues University of Dundee University becomes independent St. Andrews. of 1967 , FRS Thompson Sir D’Arcy Professor first Dundee’s Biology and pioneer of biology, mathematical of published his seminal work and Form’. Growth ‘On 1917 University College University became part the of of St Andrews. University 1897 , the first , the first Building The Carnelley purpose-built building on campus the first It is named after opens. Chemistry in Dundee, of Professor Thomas Carnelley. 1883
created Mary created Baxter Ann for College, Dundee University ‘the of persons of education and the study of both sexes and Science, Literature the Fine Arts.’
1881 History of Life Sciences Life of History 8 Research Excellence lifesci.dundee.ac.uk 11 Drug Discovery Unit
The Drug Discovery Unit is a fully operational, fully integrated fully integrated operational, Unit is a fully The Drug Discovery areas. multiple disease across working group drug discovery to in industry and academia with partners collaborate We drug targets novel into biology research world-class translate diseases activity, of areas two have We drugs. and candidate (ITP) portfolio targets and innovative world the developing of disease, cancer and diseases such as Alzheimer’s covering have we in these areas Building on the success psoriasis. with Accelerator Drug Discovery an Antibacterial developed drugs. antimicrobial new discover the aim to Our prime focus is on geomycology, the scientific study of study of the scientific is on geomycology, Our prime focus importance fundamental of fungi in processes of the roles on metal-mineral fungi impact how In particular, geology. to and bioremediation. bioweathering transformations, harness the us to these methods will allow Understanding clean up be used to may fungi. They abilities of innate the by metalloids required rare or extract waterways polluted example. for industry, electronics Drug Discovery Unit Drug Discovery Group Geomicrobiology → →
Our research focusses on the molecular machines that machines that on the molecular focusses Our research inter- cases are which in many gene function regulate DNA replication, include DNA repair, interest of Areas related. In biology. and chromatin segregation chromosome and developmental environmental study how addition, we and such as immune signalling, reproduction factors between The interplay expression. on gene impact starvation for opportunity is a lot of there means that these processes apply the aim is to forward, Looking in our research. synergy further the understanding to in gene regulation expertise diseases such as cancer. of and treatment The D’Arcy Thompson Unit encompasses all School of Life Life all School of Thompson Unit encompasses The D’Arcy Building, Carnelley the based at Sciences staff who are and Biomedical Biological undergraduate the home of focus on the These staff on city campus. Sciences teaching, and in coordinating involved activities learning and teaching work they In doing so, programmes. our degree delivering Sciences Life closely with academic staff in the School of Medicine. divisions and in the School of research and Expression Gene Regulation Thompson Unit D’Arcy → →
Plant Sciences at the James Hutton Institute
Computational Biology brings together scientists with skills scientists Biology brings together Computational mathematical and applying computational, in developing questions in biological to techniques and biophysical either have Division members and medical research. closely with “wet-lab” or collaborate “wet-lab” their own extract is to Our aim or clinicians. experimentalists the informs that data experimental maximum value from algorithms and models that predictive of development experimentally. be tested may Our researchers investigate the mechanisms of the mechanisms of investigate Our researchers cells and stem organisms, in developing differentiation in disease states. corrupted these are adult tissues and how combined are and genetic approaches Classical embryology gene understand to analyses with multi-scale systems including super-resolution/long and function, regulation cell and tissue imaging, genome-wide and term analyses modelling. mathematical Computational Biology Computational Cell and Developmental Biology Cell and Developmental
→ →
Our overarching theme is the discovery of chemical solutions of theme is the discovery Our overarching drugs new design Our purpose is to biological problems. to the causative the basic biology of understanding through alongside determining parasites such as kinetoplastid agents work Our researchers drug resistance. mechanisms of Centre Unit and Wellcome closely with the Drug Discovery the same of many and share Research, Anti-Infectives for staff and resources. Our research is relevant to the pathologies associated with associated the pathologies to is relevant Our research and disease, autoimmunity infectious diabetes, cancer, is a shared activities links A common theme that allergy. sense external cells use to in the mechanisms that interest the biochemical ‘wiring’ Remarkably, signals. and internal providing overlaps, systems diverse underlying these often among the collaboration opportunities for unexpected groups. different Cell Signalling and Immunology Biological Chemistry and Drug Discovery
Divisions and Units Units and Divisions Overview of our Centres, → → 10 Research Excellence lifesci.dundee.ac.uk 13
I lead a team of about 20 people and about 20 people of I lead a team one any at about 10 nationalities of people see how really can time. You with such a mixing benefit from people, sharing of group diverse from and also learning knowledge human day-to-day each other on the not environment This kind of level. but us as scientists only improves also as individuals.” Professor Alessio Ciulli Professor Biology Chemical and Structural of Professor
4 “ Plant Sciences at the James Hutton Institute the James Hutton Sciences at Plant Biological Chemistry and Drug Discovery Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and Ubiquitylation Phosphorylation Council Protein Medical Research Undergraduate Teaching Laboratory Teaching Undergraduate 1 2 3 4 1 2 3
Our division encompasses a spectrum of research that that research of a spectrum Our division encompasses science using model organisms fundamental from flows and economically- on medically- research translational to topics of platform on a broad Research species. significant virulence; bacterial of molecular determinants includes: fundamental pathogens; microbial to host responses including cells, in microbial processes physiological the cell surface; inter-bacterial of transport and generation for targets potential of and identification interactions; applications. or biotechnological intervention antimicrobial for centre recognised Sciences is an internationally Plant the global challenges science addressing molecular plant and conservation energy, renewable security, food of the genes and processes investigate change. We climate traits such as yield, disease plant underpinning important characteristics, developmental tolerance, stress resistance, at the located are researchers and end-use quality. Our on the outskirts Dundee with whom of Institute James Hutton This brings partnership. a long-standing strategic have we knowledge with scientists with together researchers plant our crop front-line species including in crop applied research of genetics and cultivar production. genomics, and pathogen Plant Sciences Plant Molecular Microbiology → →
The vision of the Centre is to help tackle the urgent unmet help tackle the urgent is to the Centre The vision of for research drug discovery medical need and lack of This will be achieved Diseases (NTDs). Tropical Neglected and NTD drug discovery hub for a world-leading creating by Pharma academics, choice for of being the collaborator in the translation Partnerships Development and Product also The Centre drug candidates. science into discovery of disease from in training scientists includes programmes aimed activities and public engagement endemic countries of understanding NTDs, of enhancing public awareness at it is important. and why process the drug discovery The Medical Research Council Protein Phosphorylation Phosphorylation Council Protein The Medical Research that centre research a major Unit is and Ubiquitylation of biological roles the of on the understanding focusses disruption and how and ubiquitylation phosphorylation causes human diseases such as these processes of and immune hypertension cancer, neurodegeneration, is programmes our research goal of The ultimate disorders. disease. treat to strategies improved new help develop to scientists, life between as an intersection The Unit operates we that ensure to pharmaceutical companies and clinicians together medical research, to a critical contribution make disease. of a deeper understanding reaching Our work centres on the structural, dynamic and chemical on the structural, centres Our work and by and their recognition nucleic acids, of properties further provide Our approaches with proteins. interactions (especially such as biophysics areas of understanding including single molecule spectroscopy), fluorescence, biochemistry and molecular biology. mechanistic chemistry, Medical Research Council Protein Council Protein Medical Research Unit and Ubiquitylation Phosphorylation Wellcome Centre for for Centre Wellcome Research Anti-Infectives Nucleic Acid Structure Structure Nucleic Acid Group Research → → → 12 Environment lifesci.dundee.ac.uk 15 Our Environment State-of-the-art facilities Research environment → Research → support → Outstanding in-house environment teaching → Undergraduate techologies Research Facility → Dundee Imaging Facility Proteomics → Fingerprints and Cell Sorting Cytometry Facility → Flow Cell Facility Stem → Human Pluripotent Crystallography → X-ray Other technologies Centre Phenotypic Screening → National facilities Computing → High Performance 16 Environment 18 19 Environment 14 Environment
1
Environment lifesci.dundee.ac.uk
We provide a fast-paced, collegiate and supportive environment for our staff and students. With access to state-of-the-art technologies and collaborative opportunities, it is a setting that facilitates scientific innovation and discovery.
The School of Life Sciences research complex the existing research complex. This space is a consists for four physically interlinked buildings place for meeting, collaboration and networking. with our undergraduate teaching, led by the It incorporates a café, informal break-out areas D'Arcy Thompson Unit, based separately at and a venue for public engagement. Our café and the Carnelley Building. Both locations are LifeSpace (Scotland’s first science-art research based on city campus of the University. In gallery created in partnership with the University’s addition, our Division of Plant Sciences is Duncan of Jordanstone College of Art and Design) State-of-the-art facilities Central Technical Services (media services located at the James Hutton Institute in provide the perfect place for a break from the lab. and wash up), health and safety, IT support, Invergowrie 20 minutes away. All our laboratories in the research complex are stores team, laboratory management and Sharing of latest research findings can take open-plan, which encourages collaboration and administrative support. Research environment place in one of our lecture theatres, many interdisciplinary working. They are equipped with meeting or seminar rooms. Our dynamic research state-of-the-art facilities and equipment. These Undergraduate teaching environment Our research complex has evolved over the environment is supported by a raft of different include: past five decades to continually provide our activities. These include our Annual Research → ‘wet’ laboratories for chemistry, biochemistry The Carnelley Building, our undergraduate researchers with a well-equipped and Symposium that showcases the work taking and microbiology teaching hub, is home to the D’Arcy Thompson stimulating environment. It has been designed place in the School and our prestigious named → tissue culture suites for categories 1, 2 Unit and associated staff who support the to maximise collaborative working by promoting lecture series featuring world-leading scientists, and 3 level work and designated spaces undergraduate teaching programmes. Lecture interactions across different disciplines and many of whom are Nobel Prize winners. Each for radioactivity theatres and laboratories for undergraduate research groups. This allows the best and most research Division runs its own seminar series that → rooms specially designed for working with teaching are based here. City campus amenities innovative research to take place. bring to Dundee international leaders in their various model organisms such as yeast, such as the Dalhousie Building (a designated respective fields. This provides opportunities for Drosophila, Xenopus laevis and C. elegans teaching facility that houses an array of lecture An enclosed atrium ‘Street’ was created between PhD students and postdocs to meet and discuss → in-house research technologies and expertise theatres, IT suites and general teaching spaces) our newest building, the Discovery Centre for their work with these world experts. (more details in technologies section) and the Library and Learning Centre (ranked Translational and Interdisciplinary Research and → a high quality ‘dry’ laboratory for number 1 in Scotland for library resources in the computational biology research National Student Survey, 2019), further enhance → cutting-edge plant science facilities located our students learning experience. within our Division of Plant Sciences based at Discovery Centre 'Street' the James Hutton Institute. The D’Arcy Thompson Zoology Museum is also located in the Carnelley Building. It houses many Outstanding in-house support fascinating specimens from around the world. Most of them were collected by the celebrated Sir A critical component of our research success is D'Arcy Wentworth Thompson, the first Professor the quality of infrastructure and in-house support of Biology at the University of Dundee. enjoyed by our scientists. These include our
1 Drug Discovery Unit 2 Undergraduate Teaching Laboratory 2 3 3 Discovery Centre 'Street' Café
16 17 Environment lifesci.dundee.ac.uk Technologies → Human Pluripotent Stem Cell Facility
Our School is equipped with world-class research technologies and expertise led through our Centre for Advanced Scientific We help researchers to integrate the use of human pluripotent stem cells (hiPSCs) into their work. We provide Technologies (CAST), which are available to all our staff and students. our researchers with undifferentiated embryonic stem cells (hESCs) and hiPSCs, training in working with human pluripotent stem cells, and expertise in the development The Centre for Advanced Scientific Technologies comprises of: of cell-based assays. Our facility is jointly supported by the Schools of Life Sciences and Medicine.
→ Dundee Imaging Facility → X-ray Crystallography
We exist to support the research ambitions of scientists Crystallography is the most powerful method for determining across the University. Our facilities include: light microscopy, the atomic three dimensional structures of large biological 3D structured illumination, tissue imaging, electron molecules. We provide specialist equipment and expertise to microscopy, image analysis and the physics and life science link protein structure with function and rational drug design. lab. We offer support across a broad range of imaging modalities and can advise on experimental design from sample preparation, through acquisition to analysis.
Other technologies → Fingerprints Proteomics Facility → National Phenotypic Screening Centre
We provide a state of the art proteomics and mass spectrometry capability to researchers at the University and to external academic and industrial clients across Our centre applies advanced phenotypic approaches to the globe. We have an excellent reputation for: expertise, identify new chemical biology tools, discover drugs or reliability, efficiency, delivery of service, value for money, perform other high throughput biology experiments. We and confidentiality. focus on the use of more predictive and patient-centric bioassays to increase the effectiveness of the pre-clinical drug discovery process, reducing the time and cost to translate basic research into a clinical outcome.
→ Flow Cytometry and Cell → High Performance Computing facilities Sorting Facility
We provide high-quality training and on-going technical We have facilities that allow for computational analysis, support in the use of flow cytometer analysers to enable simulation and modelling of large quantities of data. We researchers to perform independent sample analysis. Facility support a multi Petabyte scalable, hierarchical data store staff are able to provide sample and data analysis for urgent based on IBM’s Spectrum Scale (aka GPFS) filesystem. This or small-scale experiments. We also perform all cell sorting provides high speed SSD storage close to the user. For robust applications and are on-hand to provide technical support for data protection we also have daily backups to two locations. sample preparation and sort design.
18 19 Teaching and Training lifesci.dundee.ac.uk 21 Our Teaching and Training Research projects at the forefront of of the forefront at projects Research science international skills and professional Research environment collegiate and Supportive Research-led teaching → Research-led focus with a real-world → Degrees graduates → Employable of Biology Society the Royal by → Accreditation opportunities experience → Real research → → → support → Career 24 Internationalisation 25 Postgraduate 23 Undergraduate Our Teaching and Training Our Teaching 20 Teaching and Training lifesci.dundee.ac.uk 23 Real research experience opportunities experience Real research internships summer research of a number offer We invaluable giving students undergraduates, for laboratories research in real working of experience term-time) during the summer months. (outside of both University open to The schemes are elsewhere, and those from Dundee students students. including international Employable graduates graduates Employable our the importance preparing of understand We not live, in which they shape the world to graduates using pre-defined roles pre-defined simply fit into emphasise the importance we why That’s skills. our throughout and flexibility collaboration of us prepared leave our graduates and why teaching, the modern world. on the challenges of take to Society the Royal by Accreditation Biology of and integrated BSc Honours Our undergraduate in Biological programmes (MSci) degree masters full accreditation and Biomedical Sciences have from respectively and advanced accreditation This means our of Biology. Society the Royal their academic rigor for recognised are courses In addition, it acknowledges and excellence. with solid academic equip our graduates we that looking are and the skills employers foundations for. Degrees with a real-world focus focus with a real-world Degrees major with the world’s collaborations Our research companies pharmaceutical and biotechnology issues in real-world explore to our students allow their studies. of the context Our Teaching and Training Our Teaching training and nurturing consider the next of We committed We are priority. as a top generation training and supporting and scientists students to our through their careers stage of every at programmes. and postgraduate undergraduate Undergraduate undergraduate Sciences, Life In the School of the D’Arcy of members is led by teaching years recent over Thompson Unit. Their work rise rapidly up programmes has seen our degree in the top be listed consistently the rankings to Biological Sciences in the UK for 15 universities Guardian Guide 2020, University (Complete Times University Sunday Guide 2020, University Guide 2020). teaching Research-led Sciences in Life degrees Our undergraduate teaching to approaches innovative provide the by informed directly are and learning that of years In the latter our research. of excellence our internationally- courses, our undergraduate staff design and deliver acclaimed research our by is informed ensuring our teaching courses, research. world-class
The best thing about my course is that the teaching the teaching is that course my The best thing about in their students help to and beyond staff will go over opportunities since so many been given I have way. any in internships funded summer from the course, I started project an honours to the University of labs the research interests.” own me based on my for organised was that Margarita Kalamara Margarita Greece from Biological Sciences MSci student “ Life Sciences Lecture Life 22 Teaching and Training lifesci.dundee.ac.uk 25 Postgraduate Taught Research Postgraduate We offer a suite of taught MSc courses in MSc courses taught of a suite offer We which Sciences, Biomedical and Molecular studying business-include the option of such as entrepreneurship modules related focus These courses and marketing. in interest major current of on areas arm to the biopharmaceutical sector, with the particular knowledge students and pharmaceutical biotech and skills that facilities in as research companies as well looking for. academia are carry out a opportunities to also offer We by our Masters through project research or our PhD programmes. Research studentships offer Our PhD programmes overseas UK, EU and to and scholarships of funding a variety through applicants itself. the University mechanisms and from training doctoral These include 4-year the Medical Wellcome, from programmes and Council and Biotechnology Research Council. Biological Sciences Research specific opportunitiesA number of for such as the China students international also are Council Programme Scholarship available. on our PhD details can be found Further contact or please pages on our website [email protected] any for enquires. Supportive and collegiate and collegiate Supportive environment studies our postgraduate make aim to We experience. and rewarding an exciting an intellectually providing do this by We environment. work and supportive exciting excellent have The School and University students looking after support services, graduation. to week fresher’s from support Career our postgraduates provide to endeavour We capable are skills sets so they with diverse in careers making leading contributions of the over in science, business and policy to assist our students We decades. next upon employment obtain appropriate their studies. completion of Postgraduate opportunities a number of have We which students postgraduate open to their various interests address aim to are offerings All our and requirements. the following: underpinned by the forefront at projects Research science international of methods research in train students We do this through We and practice. research outstanding, high-quality international of the forefront at projects laboratories. science in well-equipped learn the During their training, students and capabilities practice, theory, in life modern techniques of limitations science research. skills and professional Research the generic skills of in train students We such as experimental research scientific and survey literature analysis, design, data for is provision There skills. communication and career professional on-going personal, This includes opportunities development. and in public engagement participate to and such as enterprise training on topics funding. research 1 2 3 MRC Doctoral Training Programme Retreat Programme Training Doctoral MRC Discovery Centre Discovery Wellcome PhD students Wellcome 1 2 3 The University has strong links with links has strong The University and China, in Malaysia Singapore, Sciences. Life of particular in the area with programme degree a joint have We partner institution, the our prestigious , one of of Singapore University National (QS in the world 15 universities the top and Rankings 2020), University World from articulating students welcome South and Central Xiamen University Taylor’s in China, and from University to continue We in Malaysia. University with institutions in build relationships we so that and beyond these countries and research. further teaching enhance our Internationalisation and is highly respected A British degree the globe. across employers valued by a long tradition we have a university, As the all over people from welcoming of an enriching which provides world all. for environment from students welcome Not only do we but our students here, other countries to study abroad the opportunity have one This can be for during their degree. Study abroad or a full year. semester and personal beneficial to is extremely and research development, professional worldwide employers that has shown with intercultural value graduates and global competences. awareness
University
50 2 → Times Higher Education World University Rankings 2020 University World → Times Higher Education World World Top Undergraduate laboratory practical laboratory Undergraduate 24 Impact and Translation lifesci.dundee.ac.uk 27 Impact and Translation Translation and collaboration with industry and collaboration Translation research interdisciplinary through Innovation generation and company Commercialisation 28 29 30 Impact and Translation and Impact 26 Impact and Translation lifesci.dundee.ac.uk 29 3 Drug Discovery Unit robot Drug Discovery Laboratory for Quantitative Proteomics Quantitative for Laboratory School of Life Sciences Building Life School of of new tools and capabilities is always tied is always and capabilities tools new of use. In collaboration scientific world, real to Cambridge and the in Bristol, with scientists in the team Institute, Bioinformatics European general biological image Dundee built the first from data and integrates stores that repository Image multiple modalities and laboratories. that (IDR) is a public database Resource Data related imaging data and integrates collects published in leading scientific experiments to to this wider accessibility This allows journals. from connections research plus new data IDR been discovered. have projects separate OME as be run by to will continue resources BioImage Archive part the wider EMBL-EBI of project. The School also houses the Laboratory for the world’s , one of Proteomics Quantitative quantitative facilities for research large This facility has analytics. and data proteomics Angus Professor led by the laboratory, allowed performing solutions for create Lamond, to proteomics high-throughput large-scale, has developed team The research projects. molecular proteomics, innovative integrated study to approaches biology and computational and disease mechanisms in gene expression humans and model organisms. 1 2 3 2 Innovation through interdisciplinary research interdisciplinary through Innovation To maximise our research impact, we place we impact, our research maximise To the at research and interdisciplinary innovation expertise Bringing together our work. of centre complex address us to disciplines allows across technology biological questions using the latest manner. in an effective and knowledge programme software , an open source Jalview of the team by and maintained created large Barton, integrates Geoff Professor such as biological sequences, of collection about with information DNA, RNA and protein in disease. It is the de- and role their function multiple sequence for software standard facto This helps scientists and analysis. alignment their sense of on genetic disease make working of the effect of the prediction and improve data in the human genome on disease. mutations (OME) Environment The Open Microscopy Jason Professor headed by team software manage, to open tools produce Swedlow image sets of large and understand analyse and build specifications to OME seeks data. open, flexible, scientists allow that software their imaging data. scalable access to as undertaken are and projects work OME’s with academic, industrial or collaborations the development so that partners, commercial 1 structure-guided low molecular weight PROTACs and has PROTACs molecular weight low structure-guided the one of chemical biology into of this area helped transform This includes significant drug discovery. of areas most exciting companies with pharmaceutical partnerships drug discovery such as Boehringer Ingelheim (BI). Therapy Signal Transduction also house the Division of We longest running (DSTT)is the world’s in 1998, which , founded and the laboratories academic research between collaboration Based within the Medical Research pharmaceutical industry. PhosphorylationCouncil Protein Unit and Ubiquitylation (MRC-PPU) the consortium pharmaceutical industry, with the and Merck, including Boehringer Ingelheim, GlaxoSmithKline million in funding since its inception. The £58 has attracted academia and how as a model for DSTT is widely regarded The funding enables productively. industry can interact in research their fundamental continue to our scientists lupus, arthritis, including cancer, multiple therapeutic areas, disease. and Parkinson’s hypertension Dario Alessi and Professor area, research In the latter the first uncovered colleagues within the MRC-PPU target LRRK2, an important of targets physiological and assays disease. Their research, enzyme in Parkinson’s by being used are measuring LRRK2 activity for reagents the preclinical allow pharmaceutical companies to several the and for LRRK2 inhibitors selective of development clinical trials first in the LRRK2 clinical biomarkers adoption of with people treat drugs to new of the effectiveness test to in involved is heavily the MRC-PPU Moreover, Parkinson’s. disease in Parkinson’s participation for stratification patient bilateral from significantly clinical trials and has benefitted the disease through with people with Parkinson’s engagement Group. Interest Research Dundee Parkinson’s
Regulating protein function through targeted degradation degradation targeted through function protein Regulating is a major (PROTACs) chimeras targeting using proteolysis harness designed to are PROTACs drug discovery. field of new (the ubiquitin-proteasome) system disposal natural the cell’s Professor disease-causing proteins. specifically remove to of Dundee is pioneering new the University Alessio Ciulli at Their work is supported by funding from a number of sources sources a number of funding from is supported by Their work Council, the the Medical Research including Wellcome, Malaria Medicines for Foundation, Bill and Melinda Gates with multi-million-pound partnerships and through Venture, Takeda pharmaceutical companies such as GlaxoSmithKline, advances include exciting Recent Pharmaceuticals and Pfizer. malaria, for treatment a single exposure of the development people of the treatment therapeutics for new of the creation with Takeda with visceral leishmaniasis and a partnership Disease. Alzheimer’s of Pharmaceuticals in the area (DDU) has a mission to make make Unit (DDU) has a mission to Our Drug Discovery therapeutic into sciences research life of the translation of areas so that and successful, efficient more applications By bridging the gap addressed. unmet need can be better drug and commercial research academic scientific between collaborate able to are they and development, discovery unexplored of fully the potential more exploit widely to Since techniques. scientific and untried therapeutic targets 100 FTEs making over to opening in 2006, the DDU has grown facilities drug discovery fully integrated the largest, it one of multiple diseases in the UK. across working Translation and collaboration with industry and collaboration Translation work we do, we what of the core is at Whilst basic research to stakeholders external of with a variety in collaboration Our School problems. world” “real solve to our work translate with industry, working of track record has a well-established income coming our research of a tenth with approximately industry-funded sources. from Impact and Translation 28 Impact and Translation
Commercialisation and company generation lifesci.dundee.ac.uk The University of Dundee has an international commercial arm of the Open Microscopy reputation in Life Sciences innovation and Environment, a community-led, open translation. It has a unique infrastructure for source data specification and software professional drug discovery and enjoys exemplary development consortium. partnerships between industry and academia. The University has a track record of sustainable → Platinum Informatics: Developing powerful spin-outs from its intellectual property. Examples new software solutions for managing of School of Life Sciences spin-outs and spin-ins complex informatics and multidimensional include: proteomics scientific datasets in a wide range of laboratory and industrial environments. 1 Fingerprints Proteomics → Amphista Therapeutics: Developing drugs Laboratory 2 Exscientia team using ground-breaking targeted protein → Ten Bio Ltd: An exciting new biotech 3 2 3 Jalview laboratory, degradation technology from the laboratory of spin out company offering innovative Computational Biology Professor Alessio Ciulli. It is backed by Advent human skin explant technology that allows Life Sciences, one of the leading trans-Atlantic superior retention of in vivo physiological 1 venture capital investors. characteristics for testing of pharmaceuticals and cosmetics products, reducing the need → Exscientia: Pioneering automated drug for testing in animal models. design methodologies that enhance the efficacy and the efficiency of drug → Ubiquigent: Enables and supports discovery for the pharmaceutical industry. ubiquitin system focussed drug discovery Exscientia collaborate with leading by developing novel compounds targeted pharmaceutical companies including Sanofi, towards ubiquitin system proteins as well Sumitomo Dainippon Pharma and Sunovion providing access to a suite of comprehensive Pharmaceuticals, Evotec and GSK. research services and reagents.
→ Glencoe Software: Design and production of software and data storage solutions for biological imaging. Glencoe Software is the
“Exscientia has demonstrated that AI in molecular design is here today. With the global pharmaceutical industry acknowledging the importance of incorporating AI-driven R&D approaches into their drug discovery processes, we see a huge growth opportunity ahead. We believe Exscientia is set to become a global leader in AI-driven drug discovery.”
Dr Rupert Vessey President of Research and Early Development at Celgene
30 31 Public Engagement lifesci.dundee.ac.uk 33 Public Engagement Engagement and sharing of knowledge of and sharing Engagement Schools Outreach 35 35 35 Partnerships Public Engagement with Research with Public Engagement 32 Public Engagement lifesci.dundee.ac.uk 35 2 Animating Science is a partnership project project Science is a partnership Animating with Dundee Contemporary Arts aims to that skills with school motion animation stop develop (P7 -S3) and support them pupils and teachers Science films about Life animated in creating concepts and processes Supporting Dundee Women’s the annual work the showcasing events include that Festival the University across in science from women of in partnership exhibition a new Developing Scotland, as well Museum of with the National and Edinburgh. Glasgow of as the Universities a Survival presents for Battle Parasites: in Scotland's leading role look at contemporary over and saw against parasitic diseases, the fight month. in its first visitors 11,000 Science ArtLifeSpace Gallery Research with Art College of and Design Jordanstone Duncan of Partnerships and creative build collaborative Our vision is to high quality, innovative deliver to partnerships inspire that programmes engagement science makes in science and participation with the wider work We everyone. for relevant the University, across staff from of expertise in organisations and culture partners external this goal. achieve to Dundee and beyond Examples include: → → → → Public Engagement leaders Public Engagement continually are team Our public engagement the boundaries in the field of pushing forward the institutional at work They public engagement. their learning and share to level and national best practice. 3 We have a strong outreach programme that aims that programme outreach a strong have We support Scotland's schools with their delivery to science, topical and aims around outcomes of and interdisciplinary careers, and ethical issues, and include school science days learning. Activities as master-classesscience clubs as well in scientific opportunities. and work-experience techniques Engagement and sharing of knowledge knowledge and sharing of Engagement of a culture create to aspire Our projects with the sharing and communication knowledge a the use of widest possible audience. Through we aim technological and artistic media of variety and novel in a number of our research deliver to ways. stimulating a wide range to contribute Our staff and students including local activities public engagement of at and within the University held events festivals, the city. across venues Schools Outreach
Street Food at Festival Festival at Food Street the Future of "Misprints" science art"Misprints" exhibition interactive Citizen Science project at Citizen Science project Garden Community Tayport
1 2 3
The work we do in the School of Life Sciences has Life do in the School of we The work shared health, our on people’s impact a significant making our science Today, and environment. economy is part the public engagement of accessible through of being a scientist.” remit and responsibility Nicola Stanley-Wall Professor Lead and Academic Molecular Microbiology of Professor Public Engagement for “ National Co-ordinating Centre for for Centre Co-ordinating National 2017 Public Engagement → st to be faculty in the UK a Gold Engage awarded Watermark
1 To us, public engagement is by definition a two-way process, process, definition a two-way is by public engagement us, To sharing for with the aim of and listening, interaction involving as scientists. part our role of mutual benefit. integral It is an learn as much from hope to we By engaging with each other this is the best way that believe we do about us – as you you progress. social and scientific true for forward with Research Public Engagement 1 34 Our people lifesci.dundee.ac.uk 37 Our people Biological Chemistry and Drug Discovery Unit Drug Discovery Research Anti-Infectives for Centre Wellcome Biology Cell and Developmental Immunology Cell Signalling and Biology Computational Unit Thompson D'Arcy and Expression Gene Regulation Council Protein Medical Research Unit and Ubiquitylation Phosphorylation Molecular Microbiology Group Research Structure Nucleic Acid Sciences Plant 38 41 42 43 44 47 48 Geomicrobiology 49 51 51 52 Overview of our people in the our of Overview Sciences Life School of 36 Our people lifesci.dundee.ac.uk 39
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CBiol FRSB Professor David Horn David Professor Pawlowic Dr Mattie and is in Biological Chemistry and Drug Discovery Research. Anti-Infectives for Centre Wellcome lab studies Cryptosporidium The Pawlowic main in two concentrates Research parasites. the basic biology and understanding areas: and drug Cryptosporidium, biochemistry of work to tools genetic new Developing discovery. will help both aims. with the parasite lifesci.dundee.ac.uk/people/mattie-pawlowic Professor Mark Field Professor and is part of Investigator Trust is a Wellcome and the Biological Chemistry and Drug Discovery Research. Anti-Infectives for Centre Wellcome of aspects studies fundamental His laboratory therapeutic new identify biology to parasite on the focussing clinical intervention, for targets brucei (the Trypanosoma trypanosome, African sleeping sickness in humans and of causal agent in sub-Saharan Africa). livestock lifesci.dundee.ac.uk/people/mark-field Gray David Professor Unit. Biology in the Drug Discovery is Head of of output for the quality He has responsibility campaigns and screening the compound of the of underpinning biological characterisation hit molecules including the integrated functions. management compound and data He is also part Biological Chemistry and Drug of Anti- for Centre and the Wellcome Discovery Research. Infectives lifesci.dundee.ac.uk/people/david-gray is a Wellcome Trust Senior Investigator. He acts He acts Senior Investigator. Trust is a Wellcome of Biological Chemistry and Drug as Deputy Head Anti- for Centre and the Wellcome Discovery on focusses His research Research. Infectives and resistance drug action variation, antigenic the to genetic screens of and the application brucei. trypanosome, Trypanosoma African lifesci.dundee.ac.uk/people/david-horn
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Professor Andrew Hopkins Andrew Professor is part Chemistry and Drug Biological of on focus activities Research Discovery. and experimental informatics novel developing of ways effective more enable new, methods to discovery. drug conducting lifesci.dundee.ac.uk/people/andrew-hopkins Bill Hunter Professor His is in Biological Chemistry and Drug Discovery. the relationships of elucidation involves research biological function to structure link protein that objectives broad The or chemical catalysis. the mechanisms whereby determine to are specific, sometimes unusual enzymes catalyze protein or where reactions biosynthetic the transport materials of regulates architecture a membrane. or signals across lifesci.dundee.ac.uk/people/bill-hunter Professor Sir Mike Ferguson Sir Mike Professor Regius Senior Investigator, Trust is a Wellcome Lead Sciences and Academic Life of Professor He is part Biological of Strategy. Research for and the Wellcome Chemistry and Drug Discovery He is also Research. Anti-Infectives for Centre Unit. His the Drug Discovery of Co-Director to a multidisciplinary approach takes research protozoan the biochemistry of understanding disease. He cause tropical that parasites trypanosome protein on understanding focusses parasite-specific and exploiting glycosylation drug discovery. for variations lifesci.dundee.ac.uk/people/mike-ferguson Ian GilbertProfessor Unit Chemistry in the Drug Discovery is Head of unmet medical need on tackling focussing He small molecule drug discovery. through Biological Chemistry and Drug is also Head of which is a multi-disciplinary and highly Discovery, division, encompassing research collaborative He research. and translational both fundamental Anti- for Centre Wellcome the of member a also is Research. Infectives lifesci.dundee.ac.uk/people/ian-gilbert CBE FRS FRSE FMedSci FRSB FMedSci FRSE CBE FRS
Category 3 Tissue Culture, Drug Discovery Unit
Professor Alan Fairlamb Professor Fellow Principal Research Trust is Wellcome specialist in the and is a world-renowned He is part of diseases. tropical biochemistry of and the Biological Chemistry and Drug Discovery Research. Anti-Infectives for Centre Wellcome Unit. the Drug Discovery of He is also Co-Director parasites study of on the focusses His research diseases – sleeping different causing three Chagas disease and leishmaniasis. sickness, lifesci.dundee.ac.uk/people/alan-fairlamb CBE FRSE FMedSci FLS FRSB CBE FRSE
FRSC Professor Alessio Ciulli Professor is in Biological Chemistry and Drug Discovery. focussed in the Ciulli laboratory Research protein-protein and targeting on dissecting within the ubiquitin and chromatin interactions spans the fields of His expertise systems. Biology and Chemical Biology and Structural he is specifically concerned with studies of to interactions protein of protein- druggability small molecule modulators. lifesci.dundee.ac.uk/people/alessio-ciulli
Biological Chemistry and Drug Discovery Biological Chemistry and Drug Discovery Drug Discovery Unit Wellcome Centre for Anti-Infectives Research
→ → → 38 Our people lifesci.dundee.ac.uk 41 Fly Lab in Cell and Developmental Biology
Dr David H. Murray H. Murray Dr David aims to His group is a Sir Henry Dale Fellow. the basic molecular mechanics in understand such as subcellular structures, of the formation structures These polarity and migration. those of human critical to are regulation and their proper an interdisciplinary takes health. The group biophysical bridging membrane approach state-of-the-art biochemistry, methods to protein imaging, and cell biology. lifesci.dundee.ac.uk/people/david-murray Storey Kate Professor and Senior Investigator Trust is a Wellcome Biology. Developmental Cell and Head of the cellular and molecular She investigates and has neurogenesis; direct mechanisms that cell sub- of form a new discovered recently division, apical abscission, which regulates differentiation. neuronal lifesci.dundee.ac.uk/people/kate-storey FRSE FMedSci FRSA FRSB FMedSci FRSA FRSE
Dr Philip Murray Dr Greg Findlay Dr Greg Stravidis Dr Marios is a Lecturer in Mathematics in the School of Science and Engineering in the School of in Mathematics is a Lecturer His research Biology. Cell and Developmental of and an associate growth hair follicle include tumour modelling, somitogenesis, interests crypt modelling and intestinal mechanisms, DNA repair patterning, cell populations. models of continuum to discrete Associates → → → lifesci.dundee.ac.uk/people/philip-murray lifesci.dundee.ac.uk/people/philip-murray
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FRSB FRSE Professor Inke Näthke Näthke Inke Professor Culture. Professional Dean for is Associate is to in her laboratory research The aim of the in cancer of the earliest changes identify the molecular determining by tract intestinal the of the functions govern mechanisms that in the major tumour suppressor APC protein, she combines her work this tissue. For approaches biochemical and cell biological with multi-dimensional understand imaging to shapes the dynamics cell behavior stem how and diseased tissue. healthy of lifesci.dundee.ac.uk/people/inke-nathke Pauline Schaap Professor Her Senior Investigator. Trust is a Wellcome in using a Dictyostelid lie interests research the signalling pathways investigate model to crucial whether and explore encystation of be might in these pathways proteins regulatory drugs to the design of for suitable targets inhibit encystation. lifesci.dundee.ac.uk/people/pauline-schaap Weijer Kees Professor on cell-cell signalling is focussed His research during cell movement and chemotactic In particular he uses a development. imaging advanced in-vivo of combination and analysis data methods and computational study cell movement to modelling techniques in the chick embryo. during gastrulation lifesci.dundee.ac.uk/people/kees-weijer
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Dr Jens Januschke Dr Jens Januschke McGurk Dr Leeanne on understanding is focussed Her research called modification the posttranslational how the brain. Her work aging of impacts PARylation how of understanding a broad aims toward and to in brain function is involved PARylation whether pharmacological strategies determine therapeutic could have this pathway target that takes disease. Her group in neurological potential combines that approach an interdisciplinary with cultured genetics together Drosophila with in vitro mammalian cells and neurons biochemical techniques. lifesci.dundee.ac.uk/people/leeanne-mcgurk Professor Paul Wyatt Professor Unit and Director the Drug Discovery is Head of Anti-Infectives for Centre the Wellcome of He is also part Biological Chemistry of Research. develop is to His role and Drug Discovery. bringing Dundee, by at research translational drug of experience his and others' together with sector Pharma/Biotech in the discovery de- risk to sciences research basic academic life and develop drug discovery for targets novel diseases such as malaria for treatments new and cancer. lifesci.dundee.ac.uk/people/paul-wyatt is a Sir Henry Dale Fellow and Deputy Head of and Deputy Head is a Sir Henry Dale Fellow He leads a Biology. Cell and Developmental the mechanisms examine to group research cell polarity in consecutive stem controlling central Drosophila divisions in the developing he is using life-cell In particular, system. nervous study the dynamics of to imaging approaches division. in asymmetric cell polarisation lifesci.dundee.ac.uk/people/jens-januschke
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Professor Carol MacKintosh Carol Professor Sciences. studies in Life Postgraduate is Head of 14-3-3 how is discovering Her laboratory intracellular of a constellation regulate proteins of specific pairs docking onto by targets residues, serine/threonine phosphorylated domains and inducing masking functional is then This data changes. conformational that networks regulatory construct used to to cancer, relevant phenotypes explain and metabolic disorders. neurodevelopmental lifesci.dundee.ac.uk/people/carol-mackintosh Professor Kim Dale Professor and Fellow Research Society University is a Royal interest The broad Dean, International. Associate of further understanding to is her laboratory of play come into genetic interactions several how build to development the earliest stages of at specifically her More embryo. the developing cells and stem streak primitive analyses research choice cell fate in regulating Notch of the role pools. progenitor within these multipotent lifesci.dundee.ac.uk/people/kim-dale is Head of Drug Metabolism and is Head of Unit. His Drug Discovery Pharmacokinetics in the lead optimisation drive successfully passion is to with the medicinal closely working forward, candidate high quality deliver chemists to preclinical formal into entry molecules for is also part He Biological of development. and the Wellcome Chemistry and Drug Discovery Research. Anti-Infectives for Centre lifesci.dundee.ac.uk/people/kevin-read Professor Kevin Read Kevin Professor Dr Susan Wyllie Dr Susan Wyllie is part Biological Chemistry and Drug of Centre the Wellcome member of a key Discovery, and is the Head of Research Anti-Infectives for is focused Her group Group. Action the Mode of of the molecular targets primarily on determining that killing the parasites compounds capable of The Diseases (NTDs). Tropical cause Neglected a vital play these studies provide that insights group NTDs and Susan’s for in drug discovery role Unit. closely with Drug Discovery works lifesci.dundee.ac.uk/people/susan-wyllie Cell and Developmental Biology andCell Developmental → 40 Our people lifesci.dundee.ac.uk 43 Computational Biology
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Dr Andrei Pisliakov Pisliakov Dr Andrei and explain to research computational conducts complexes protein of the functioning predict biological processes, in key important are that molecular conversion, such as cellular energy tackle To transport, catalysis. and enzyme a he employs these challenging problems, extensively methods, computational range of in close and works using supercomputers, He is a groups. with experimental collaboration Life the Schools of between appointment joint Engineering. Sciences and Science and lifesci.dundee.ac.uk/people/andrei-pisliakov Sknepnek Dr Rastko is a Lecturer and Dundee Fellow. His main and Dundee Fellow. is a Lecturer on understanding focus efforts research in biological and soft processes physical he In particular, systems. condense matter and shape formation in pattern is interested biological and artificialin multi-component and cell and tissue mechanics membranes, He is a joint systems. self-propelled active, Life the Schools of between appointment Sciences and Science and Engineering. lifesci.dundee.ac.uk/people/rastko-sknepnek Associate Jason Swedlow Professor
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Professor Geoff Barton Geoff Professor Dr Gabriele Schweikert leader Biology and a group is in Computational Germany. Tübingen, Initiative, in the Cyber Valley is in understanding interest Her main research cells with provide epigenetic mechanisms that phenotypic plasticity and enable adaptive uses She changing conditions. to responses machine-learning technologies and develops high-dimensional complex, understand better to recorded readily are that epigenomic footprints using sequencing technologies. lifesci.dundee.ac.uk/people/gabriele-schweikert cyber-valley.de/en Ulrich Zachariae Professor on developing is focussed His research of Simulations and Coarse-Grained Atomistic A particular interest and Membranes. Proteins ion channels through of is the investigation which allows electrophysiology, computational and channel ion conductance of the prediction gradients. based on electrochemical selectivity lifesci.dundee.ac.uk/people/ulrich-zachariae is Head of Computational Biology and an Biology and an Computational is Head of and Expression. Gene Regulation of associate and on the development centres His research the methods for computational of application his tools of Several biological data. of analysis and Jpred (www.jalview.org) such as Jalview (www.compbio.dundee.ac.uk/www-jpred) scientists thousands of of tens used by are world-wide. lifesci.dundee.ac.uk/people/geoff-barton Computational Biology Computational →
FRS FRSE FMedSci FRSE FRS Dr Henry McSorley of Cell Signalling and Deputy Head is joint on identifying focuses His research Immunology. which by the molecules and molecular pathways the host immune modulate parasitic worms these findings towards and developing system, human immune-mediated for treatments new diseases such as asthma. lifesci.dundee.ac.uk/people/henry-mcsorley Dr Gabriel Sollberger crosstalk and why how understand to wants occurs pathways cell death different between has on the this crosstalk implications and what of or the development infections clearance of immune cells, on innate disease. He will focus how and investigate, particularly neutrophils, mechanism as a defense use cell death they against pathogens. lifesci.dundee.ac.uk/people/gabriel-sollberger Professor Doreen Cantrell Cantrell Doreen Professor Hardie Grahame Professor is a Wellcome Trust Principal Research Fellow. Fellow. Research Principal Trust is a Wellcome on T focused are interests Her research a key and activation, development lymphocyte manipulation and the comprehension to process mammalian immune responses. of lifesci.dundee.ac.uk/people/doreen-cantrell current His Investigator. Trust is a Wellcome non- on uncovering is focussed research AMP- of regulation for canonical pathways kinase cascade. This research protein activated of the treatment into insights has provided He is a visiting obesity and cancer. diabetes, in China. Xiamen University at Professor lifesci.dundee.ac.uk/people/grahame-hardie CBE FRS FRSE FMedSci FRSE CBE FRS
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Dr Ignacio Moraga Dr Ignacio Moraga aims to His research is a Sir Henry Dale Fellow. trigger cell surface receptors how understand specific signalling cascades and biological upon ligand binding, with a strong responses of understanding A better on cytokines. focus in the their responses diversify cytokines how the designing of allow would immune system treat therapies to specific and less toxics more cytokine where disorders range of the large occurs. deregulation lifesci.dundee.ac.uk/people/ ignacio-moraga-gonzalez His research is aimed at understanding how how understanding is aimed at His research regulate to immune cells utilise host glycans and responses immune and inflammatory human disease. In particular this to translating the on the study of is focussed his laboratory lectins, sialic acid binding Ig-like siglec family of in his laboratory. discovered which were of many lifesci.dundee.ac.uk/people/paul-crocker Hari Hundal Professor of Cell Signalling and Deputy Head is joint on the in his lab focusses The work Immunology. that signalling processes intracellular of control fuels and metabolism of storage uptake, regulate and hormonal, stress to glucose) in response (e.g. nutritional cues. lifesci.dundee.ac.uk/people/hari-hundal is Head of Cell Signalling and Immunology. His His Cell Signalling and Immunology. is Head of the roles in is primarily interested laboratory play immune system the innate cells of that they and how inflammation in coordinating immunity via adaptive of activation to contribute how Understanding cytokines. of the production immunity and how control to act these pathways disease is to contribute may their disregulation in his group. research of the major focus lifesci.dundee.ac.uk/people/simon-arthur Paul Crocker Professor Professor Simon ArthurProfessor
Cell Signallingand Immunology
Dr Mahima Swamy Woof Jenny Professor → → Associates → 42 Our people lifesci.dundee.ac.uk 45
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FRSB CSciTeach FPhysiol CSciTeach FRSB Dr Stephen Land Dr Stephen the Biomedical degree for Lead is Programme BSc degrees which incorporates programme Neurosciences, in Biomedical Sciences, Sciences. Pharmacology and Physiological a range of to contributes Stephen modules within degrees undergraduate but has a specialist focus spanning all years molecular physiology, to related in areas and exercise. respiration development, lifesci.dundee.ac.uk/people/stephen-land Matthews Dr Sharon in background with a research is a Lecturer a range of to contributes Sharon immunology. modules within degrees undergraduate but has a specialist focus spanning all years cell signalling biochemistry, to related in areas and immunology. lifesci.dundee.ac.uk/people/sharon-matthews-0 Professor Kim Dale Professor and is also Dean, International is Associate for International Lead Academic University to role is region. Her in the ASEAN activity and partnerships international key develop provide Sciences and to Life to recruitment our opportunities for promote and actively She is a study abroad. to undergraduates University. Taylor’s at visiting Professor lifesci.dundee.ac.uk/people/kim-dale Dr Sheriar Hormuzdi and and scholarship in teaching is a Lecturer in neuroscience. background has a research 1 and 2 teaching level Sheriar is part the core of all curriculum across a core delivering team, Sciences degrees. Life lifesci.dundee.ac.uk/people/sheriar-hormuzdi
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FHEA FBPhS FHEA FRSB Dr Stephen Kelley Kelley Dr Stephen and scholarship. in teaching is a Lecturer and background has a research Stephen Alongside specialism in pharmacology. teaching Stephen undergraduates, Sciences Life teaching in Dundee. students medical also lectures lifesci.dundee.ac.uk/people/stephen-kelley Martin Dr David and scholarship. in teaching is a Senior Lecturer 1 and 2 teaching level is part the core of David all curriculum across a core delivering team, is His particular focus Sciences degrees. Life bringing literacy, and data on numeracy the approach methodologies into quantitative as part their developing of take students that scientists. as active roles lifesci.dundee.ac.uk/people/david-martin Dr Arthur Crossman and scholarship. in teaching is a Lecturer in synthetic background Arthur has a research biology and chemical chemistry, organic His teaching analytical chemistry. associated alongside synthesis specialism is organic skills. and research laboratory lifesci.dundee.ac.uk/people/arthur-crossman Dr Melissa D’Ascenzio and scholarship. in teaching is a Lecturer and background Melissa has a research chemistry. specialism in organic teaching who is on those students Her particular focus choose our Biological Chemistry and Drug She is co-Chair pathway. degree Discovery committee. SWAN the SLS Athena of lifesci.dundee.ac.uk/people/melissa-dascenzio
Undergraduate Cell Culture Facility, Carnelley Building
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Professor David Coates David Professor and has a Fellow Award is a Chancellor’s molecular biology. in plant background research classes, specialism is laboratory His teaching to in genetics and molecular approaches largely in has a particular interest David research. and is quality assurance and accreditation, Degree of Biology’s Society the Royal chair of Committee. Accreditation lifesci.dundee.ac.uk/people/david-coates Dr Nick Brewer and Dean, Learning is a Reader and Associate the lead for He is also the programme Teaching. programmes. Co-Curriculum and Foundation across He leads on the learning and teaching with a programmes, all the undergraduate journey. particular emphasis on the student specialism is chemistry and His teaching biology. as applied to physics lifesci.dundee.ac.uk/people/nick-brewer MBE CBiol FRSA FRSB FLS FRSB MBE CBiol FRSA
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Dr Graham Christie Dr Graham core for Lead and Programme is a Senior Lecturer 1 and 2. Graham is responsible curriculum levels and oversees students ~400 undergraduate for 25 of and assessment delivery the management, specialism is physiology, His teaching modules. on a and he teaches systems cells to from with this topic. associated modules number of lifesci.dundee.ac.uk/people/graham-christie Dr David Booth Dr David and has a research is a Senior Lecturer and evolutionary in population background on undergraduate teaches David genetics. with these themes. modules associated lifesci.dundee.ac.uk/people/david-booth D’Arcy Thompson Unit Unit Thompson D’Arcy → 44 Our people lifesci.dundee.ac.uk 47
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is Head of Gene Regulation and Expression. and Expression. Gene Regulation is Head of how investigating group He leads a research gene to contributes structure chromatin his contributions for He is best known regulation. ATP-dependent how of the understanding to nucleosomes. remodel molecular motors lifesci.dundee.ac.uk/people/tom-owen-hughes Professor Jason Swedlow Professor Professor Julian Blow Professor and Investigator Senior Trust is a Wellcome His personal Sciences. Life the School of Dean of a molecular at understand aims to research is replication chromosome that the way level DNA is of duplication precise how regulated, in the cells deal with errors and how ensured process. replication lifesci.dundee.ac.uk/people/julian-blow Ron Hay Professor His Senior Investigator. Trust is a Wellcome on the role focussed has interest research in proteins ubiquitin-like ubiquitin and of He is currently transcriptional regulation. mass high-resolution quantitative employing quantitative carry out to spectrometry the Small Ubiquitin-like of analysis temporal to as cells respond proteome Modifier (SUMO) various challenges. lifesci.dundee.ac.uk/people/ron-hay Owen-Hughes Tom Professor His lab focusses on studies of mitotic mitotic on studies of His lab focusses dynamics and and structure chromosome leading papers has published numerous in the field. He is co-founder the Open of a community- (OME), Environment Microscopy develops that project software led open source biological imaging. for and tools specifications Biology. Computational of He is an associate lifesci.dundee.ac.uk/people/jason-swedlow
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Dr Federico Pelisch Pelisch Dr Federico His Fellow. Development Career is an MRC on understanding focuses research during meiosis segregation chromosome elegans as a model. His C. using the nematode high- and combines genetic tools, research and biochemistry super-resolution microscopy, his aims. achieve to lifesci.dundee.ac.uk/people/federico-pelisch Dr Constance Alabert Fellow. Research UK Senior is a Cancer Research in the on DNA replication focusses Her research for and its implications chromatin of context cancer. human diseases such as lifesci.dundee.ac.uk/people/ constance-alabert Cowling Victoria Professor Angus Lamond Professor is a MRC Senior Fellow and Deputy Head of and Deputy Head Senior Fellow is a MRC Her research and Expression. Gene Regulation function the synthesis, on investigating focuses the mRNA methyl of and therapeutic potential the mRNA that has shown Her research cap. of integrator as a master cap operates methyl production protein which drives cellular signals, a new has revealed in the cell. This research to relevant biological process fundamental cell growth. all cells regulate how understanding lifesci.dundee.ac.uk/people/victoria-cowling Quantitative for the laboratory of is Director on seminal work He has pioneered Proteomics. of organisation and functional the structure mammalian cells and leads an the nucleus of analysis data develop to team interdisciplinary proteomics. for software and warehousing lifesci.dundee.ac.uk/people/angus-lamond Gene Regulation and Expression Expression and Regulation Gene →
Gene Regulation and Expression
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Dr Marios Stavridis Stavridis Dr Marios Zomerdijk Dr Joost Gene Regulation of is a Reader and an associate Life He is the School of and Expression. student international for Sciences coordinator developing and academic lead for exchanges Biological for degrees postgraduate taught focus His research and Biomedical Sciences. in is on the molecular mechanisms and control I. RNA polymerase transcription by lifesci.dundee.ac.uk/people/joost-zomerdijk is Programme Lead for the Biological Sciences for Lead is Programme Cell and of and an associate programme degree focusses His research Biology. Developmental pluripotent of on the biochemical properties cells (mouse and stem cells such as embryonic the early embryo. human) and cells of lifesci.dundee.ac.uk/people/marios-stavridis
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Professor Jenny Woof Woof Jenny Professor Academic Dean, Quality and is Associate Cell Signalling of and is an associate Standards Dean is to as Associate Her role and Immunology. ensure to programmes our undergraduate review delivery of standards the highest of reach we assessment, of with fairness and consistency of our enhance the quality to ways and look for focusses Her research on year. year programmes and the structure in particular, on immunology, and their receptors. immunoglobulins of function lifesci.dundee.ac.uk/people/jenny-woof Professor John Peters John Peters Professor in background a research with is a Lecturer and neuropharmacology. neurophysiology his informs in these areas His expertise and specialism in physiology teaching Sciences Life Alongside teaching pharmacology. medical and John also lectures undergraduates, in Dundee. students dental lifesci.dundee.ac.uk/people/john-peters 46 Our people lifesci.dundee.ac.uk 49
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Professor Karim Labib Karim Professor John Rouse Professor signal cells detect, on how centres His research deal with they DNA damage and how and repair has His laboratory DNA replication. to blocks in mammalian cells factors a range of discovered DNA damage of repair for instrumental are that he Furthermore forks. replication and broken drug anti-cancer new in identifying is involved arena. in the DNA repair targets lifesci.dundee.ac.uk/people/john-rouse Professor Sir Philip Cohen Professor FFMedSci FAA FRSE FRS and Senior Investigator Trust is a Wellcome Signal the Division of of Co-Director research His current Therapy. Transduction signal transduction on dissecting is focussed immune the innate regulate that networks bacteria by during infection activated system understand is to A particular focus and viruses. phosphorylation protein between the interplay the regulating in ubiquitylation and protein drug validate and to immune system, innate and inflammatory of the treatment for targets diseases. autoimmune lifesci.dundee.ac.uk/people/philip-cohen Dr Ian Ganley is a Wellcome Trust Senior Investigator. His Senior Investigator. Trust is a Wellcome of and regulation on the roles focusses research genome in preserving replisome the eukaryotic and epigenetics. integrity lifesci.dundee.ac.uk/people/karim-labib Research activities focus on deciphering the focus activities Research that events and ubiquitylation phosphorylation is part his work of A large on autophagy. switch kinase autophagy-essential on two concentrated kinase either the protein containing complexes ULK1 or the lipid kinase VPS34. lifesci.dundee.ac.uk/people/ian-ganley
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Dr Yogesh Kulathu Kulathu Dr Yogesh understand is to his lab goal of The research is regulated cellular signal transduction how ubiquitylation the combined influences of by aims to His research and phosphorylation. and mechanistic the structural characterise of regulation principles underlying allosteric ubiquitylation. enzymes by lifesci.dundee.ac.uk/people/yogesh-kulathu Muqit Miratul Professor in Clinical Fellow Senior Research is a Wellcome Neurologist Science and an Honorary Consultant on Hospital. His lab is focussed Ninewells at mechanisms decoding the signal transduction disease and in particular underlying Parkinson’s the PINK1 kinase and of deciphering the roles mutated Parkin ubiquitin ligase whose genes are Parkinson’s. of familial forms in rare lifesci.dundee.ac.uk/people/miratul-muqit Professor Dario Alessi Professor Findlay Dr Greg of and an associate is a Sir Henry Dale Fellow His laboratory Biology. Cell and Developmental phosphorylation of in the role is interested in embryonic networks and ubiquitylation with the aim determination, cell fate stem cells can be stem how understanding of human disease. treat or applied to manipulated lifesci.dundee.ac.uk/people/greg-findlay the MRC Protein Phosphorylation Phosphorylation Protein the MRC of is Director of Signal Unit and the Division and Ubiquitylation has Unit. His laboratory Therapy Transduction in cell signalling, in carried out landmark work on kinases and research which he has pioneered exciting diseases providing in inherited their role conditions such as Parkinson's into insights new disease, cancer and hypertension. lifesci.dundee.ac.uk/people/dario-alessi Medical Council Protein Research Phosphorylation and Ubiquitylation Unit →
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Dr Kasper Rasmussen Dr Kasper epigenetic on dissecting focusses His research self- control that mechanisms in gene regulation hematopoietic of and differentiation renewal he In particular, cells. and progenitor stem the DNA regulating is studying the proteins and in vivo using in vitro landscape methylation hematopoiesis. models of lifesci.dundee.ac.uk/people/kasper-rasmussen Professor Geoff Barton Geoff → Professor → Dr Gabriele Schweikert Simpson Gordon → Professor Zomerdijk → Dr Joost
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Professor Geoffrey Gadd Geoffrey Professor is in the geoactive interest His research and their microorganisms of properties The processes. biosphere importance in key is on metal-mineral transformations prime focus and physiological and understanding metals and toxic to morphological responses mineral mechanisms of mineral substrates, novel of dissolution, and the formation of He is an associate biominerals. mycogenic Molecular Microbiology. lifesci.dundee.ac.uk/people/geoff-gadd Professor Daan van Aalten Daan van Professor and his papers scientific 170 over is author of the molecular are interests research long term the fungal cell wall, and biogenesis of basis of in neurodevelopmental O-GlcNAc of the role He is a guest diseases. and neurodegenerative South Central Xiangya Hospital at at Professor in China. University lifesci.dundee.ac.uk/people/daan-van-aalten Professor Tomo Tanaka Tomo Professor Fellow. Research Principal Trust is a Wellcome on dissecting is focussed His research the in regulating the mechanism involved in mitosis. interaction kinetochore-microtubule the Dundee for Lead is also Academic Tomo Imaging Facility. lifesci.dundee.ac.uk/people/tomo-tanaka FRSE FRSB FLS FLSW FRSB FRSE Geomicrobiology Group Geomicrobiology → Associates 48 Our people lifesci.dundee.ac.uk 51
FRSE FRSB FEAM SFHEA FRSB FRSE Dr David Norman Dr David His research Group. is a Reader in the Research to methods of biophysical uses a variety of and function the structure investigate have efforts Recent and nucleic acids. proteins on using pulsed Electron focussed Paramagnetic Resonance (pEPR) in conjunction long distance spin labelling for with site-specific in protein measurements and orientation the MSci Integrated He is the lead for complexes. Programme. Masters lifesci.dundee.ac.uk/people/david-norman Dr Sarah Coulthurst Dr Sarah Senior Research Trust is a Reader and Wellcome how elucidate aim is to Her research Fellow. and interact able to are pathogens bacterial cells and with with other bacterial interfere the use of particularly through host organisms, utilise Her laboratory systems. secretion protein molecular genetics, from of approaches a variety to through biology and classical microbiology, and cell biology. proteomics biochemistry, lifesci.dundee.ac.uk/people/sarah-coulthurst Nicola Stanley-Wall Professor for Lead the Division and Academic is Head of the School. Her research for Public Engagement using molecular biology on centred are interests that the signalling processes understand to by exhibited multicellular behaviours control in In particular her lab is interested bacteria. biofilm control that the genetic components bacterium the Gram-positive by formation Bacillus subtilis. lifesci.dundee.ac.uk/people/nicola-stanley-wall
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is interested in understanding how bacteria, bacteria, how in understanding is interested able , are aeruginosa especially Pseudomonas under conditions their activities regulate to Understanding growth. active prevent that bacteria antibiotic-tolerant these non-growing, to strategies into insight us new could give the rise of and combat infection chronic treat resistance. antibiotic lifesci.dundee.ac.uk/people/megan-bergkessel Professor David Lilley David Professor His research Group. the Research of is Director helical junctions of is in the structure interest RNA, and the origins of in DNA and the folding active He is very in RNA molecules. catalysis of with science in China links of in the promotion Xiamen University at and is a visiting Professor Xiamen and at and is a visiting Professor Nankai University’s. lifesci.dundee.ac.uk/people/david-lilley Dr Megan Bergkessel Dr Helge Dorfmueller focus His research is a Sir Henry Dale Fellow. the underlying of lies on the elucidation a virulence factor synthesis mechanisms to Gram-positive, a pyogenes, in Streptococcus His research pathogen. human exclusive microbiology, combines genetics, team and glycobiology, structural biology, synthetic the detailed understand to screening inhibitor reveal to in order biosynthesis, mechanisms of vulnerability. of points novel lifesci.dundee.ac.uk/people/helge-dorfmueller Molecular Microbiology Molecular Group Research Structure Acid Nucleic → Gadd Geoff → Professor → Associate
Medical Research Council Protein Phosphorylation and Ubiquitation Unit
Dr Esther Sammler consultant Leader, is a Clinical Programme Hospital and Honorary Ninewells at neurologist of the University at Senior Clinical Lecturer on aligning is focussed Dundee. Her research with pathways disease into mechanistic insight of people genetics and clinical phenotyping Disease. Parkinson’s by affected lifesci.dundee.ac.uk/people/esther-sammler Dr Mahima Swamy of and an associate is a Sir Henry Dale Fellow Her research Cell Signalling and Immunology. of and regulation study the function aims to Understanding lymphocytes. intraepithelial of understanding better them will lead to disorders, bowel diseases such as inflammatory and cancer. infections lifesci.dundee.ac.uk/people/mahima-swamy
Dr Satpal Virdee Dr Satpal composed uses a multidisciplinary approach and biochemical, structural synthetic, of His laboratory chemical genetic methods. studies the various polyubiquitin topologies decoded. He also has an are they and how the ubiquitin in the mechanism of interest machinery. conjugation lifesci.dundee.ac.uk/people/satpal-virdee Dr Adrien Rousseau Dr Adrien on understanding is focussed His research proteasome control signalling pathways how unravel his lab is to The goal of homeostasis. phosphorylation protein between the crosstalk especially how degradation, and proteasomal to degradation protein regulates phosphorylation requirements. meet the cell’s lifesci.dundee.ac.uk/people/adrien-rousseau Dr Gopal Sapkota the on understanding is focussed His research molecular mechanisms and consequences of in pathways signal transduction TGFa/BMP In particular he is cells and human diseases. which reversible in the mechanism by interested regulate and ubiquitylation phosphorylation He is pathways. these signal transduction committee. SWAN co-Chair the SLS Athena of lifesci.dundee.ac.uk/people/gopal-sapkota 50 Our people lifesci.dundee.ac.uk 53 Plant Sciences at the James Hutton Institute.
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Professor Gordon Simpson Gordon Professor an Sciences and of Plant is Deputy Head and Expression. Gene Regulation of associate RNA and of on the role focusses His research development in controlling RNA processing as a model system. using Arabidopsis thaliana approaches in unbiased is anchored His research molecular genetics and genome- involving using third gene expression of wide analyses true single molecule sequencing. generation lifesci.dundee.ac.uk/people/gordon-simpson
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Dr Sarah McKim Dr Sarah Fellow. Research of Edinburgh Society is a Royal on the developmental is focussed Her research is Her laboratory architecture. plant biology of controlling the transcription factors examining and architectures stage- specific morphologies miRNA of and Arabidopsis and the role in barley in this process. regulation lifesci.dundee.ac.uk/people/sarah-mckim Robbie Waugh Professor His work has concentrated on three major on three has concentrated His work (i) assembling and utilising elements research genetic high resolution to germplasm suited and molecular tools (ii) developing analysis gene identification facilitate that approaches to and (iii) contributing and validation barley a reference derive to efforts international genome sequence. lifesci.dundee.ac.uk/people/robbie-waugh
FRSB Dr Ingo Hein plant the disciplines of connects His work is His research genetics. and potato pathology of and applied aspects the fundamental aimed at as genetics genomics as well and pathogen crop biotic threats. against protection crop deliver to lifesci.dundee.ac.uk/people/ingo-hein Dr Edgar Huitema Dr Jorunn Bos Fellow. Research of Edinburgh Society is a Royal aphids and how elucidate aims to Her group the molecular with each other at interact plants and incompatible compatible during both level on identifying is focussed Research interactions. and biochemical, metabolic and characterising and how aphids target that signalling pathways aphid host range. this impacts lifesci.dundee.ac.uk/people/jorunn-bos Bulgarelli Dr Davide Research of Edinburgh Society is a Royal combinaton a deploys His research Fellow. molecular cellular biology, metagenomics, of biology tools and computational microbiology function the structure, further understand to thriving at the microbiota of and host control interface. the root-soil lifesci.dundee.ac.uk/people/davide-bulgarelli His research is focussed is focussed His research is a Senior Lecturer. virulence the mechanisms of on examining acquisition during Phytophthora-host harness both aims to His laboratory associations. effector of the role about understanding new P. of during disease, and the availability proteins study and perturb to capsici genome sequences, and delivery effector control that the pathways their activities. lifesci.dundee.ac.uk/people/edgar-huitema
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Dr Piers Hemsley protein how understand aims to His group control to acts (palmitoylation) S-acylation particular with function, emphasis protein and responses in stress on its role in plants. development lifesci.dundee.ac.uk/people/piers-hemsley Professor Claire Halpin Claire Professor group Her research Dean, Research. is Associate lignin biosynthesis main areas, on two focusses and use barley They and meiotic recombination. lignin and manipulate to Arabidopsis in this work lignin biosynthesis. to genes related new discover on barley also focusses Meiotic recombination breeding. crop improve with aim of lifesci.dundee.ac.uk/people/claire-halpin Professor John Brown Professor address is to his research of The main objective alternative of the mechanisms and functions as splicing using Arabidopsis and barley has developed His laboratory model systems. which has system high resolution a sensitive, dynamic changes in of the analysis allowed many splicing genes and address alterative including the splicing regulation questions of splicing factors. various plant of function lifesci.dundee.ac.uk/people/john-brown Professor Paul Birch Professor studies group His Sciences. Plant is Head of blight late potato the from proteins effector This infestans. Phytophthora pathogen, - haustoria develops pathogen eukaryotic an form that cell structures finger-like with the host plasma interaction intimate disease. membrane during the early stages of a are haustoria that has shown His laboratory proteins a class of of delivery of major site called RXLR effectors. lifesci.dundee.ac.uk/people/paul-birch Plant Sciences Sciences Plant → 52 Our location lifesci.dundee.ac.uk 55 3 V&A Museum of Design, Dundee Waterfront V&A Museum of Magdalen Green, Dundee City Centre Magdalen Green, Broughty Ferry Castle, Dundee Broughty Tay Rail Bridge, Dundee City Centre Rail Bridge, Dundee City Tay 1 2 3 4 1 2 4 Amsterdam Schiphol Airport - Amsterdam 1 hour 25 minutes Paris CDG Airport - 1 hour 45 minutes London Airports London - 1 hour - 1 hour 10 mins Edinburgh - 1 hour 30 mins Glasgow - 5 hours Manchester 20 mins Birmingham - 5 hours - 6 hours London Dundee to... Scottish airport to: flights London Birmingham Manchester Newcastle Edinburgh Aberdeen Cardiff Liverpool Dundee asgow Gl
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Being at the heart of Scotland’s road and road the heart Scotland’s of Being at skiing, scenery, puts spectacular rail network climbing and mountain championship golf, reach. sailing within easy and Glasgow Edinburgh The major cities of main four Scotland’s a short trip away. are national airports all operate international cost and low such as British Airways, airlines, all the get to to it easy This makes airlines. the UK and Europe. of major centres dundee.ac.uk/travel Our Location 54 At a glance World-class
“We are one of the strongest research Our achievements at a glance lifesci.dundee.ac.uk centres in Europe but it isn’t just about producing world-class results in our science and research – we also strive to be world-class in how we work together World Top as people. It is a great place to be TOP st because we are big enough to include 5 in the UK 50 in UK great diversity among our people and 2 ideas, but small enough to know each 1→ First faculty in the UK → Ranked Top 5 in UK → We are one of Times Higher for Biological Sciences Education’s world top 250 to be awarded a Gold Engage other. The same applies to the city, courses in 2020 by University universities and UK University of Watermark by National where the people are great supporters Guides (Sunday Times and the Year for Student Experience Co-ordinating Centre for of the work of the University.” Complete University) (The Times & The Sunday Times Public Engagement 2017
Good University Guide 2020) Inke Näthke Associate Dean for Professional Culture and Professor of Epithelial Biology World Top Top research TOP grant 0 100 4 income → World5 Top 50 → World Top 100 → Fourth highest proportion The only UK university ranked in the Nature Index 2019 for of research grant income in the world top 50 of the research quality to total income of any 2017 Nature Innovation Index UK university
ranked
in the 201 9 Top № World → Ranked Top in the UK → Ranked top in the UK → Ranked 5No. 5 in the UK NSS 2019 – Molecular Biology for biological sciences research for impact of scientific research ranked top in the UK for student in the Research Excellence - CWTS Leiden Rankings 2019 satisfaction Framework (REF) 2014
*Stats were correct at time of printing, February 2020
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