PDMP) Grantees on Responding to Performance Measures
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Properties and Units in Clinical Pharmacology and Toxicology
Pure Appl. Chem., Vol. 72, No. 3, pp. 479–552, 2000. © 2000 IUPAC INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY AND LABORATORY MEDICINE SCIENTIFIC DIVISION COMMITTEE ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)# and INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY CHEMISTRY AND HUMAN HEALTH DIVISION CLINICAL CHEMISTRY SECTION COMMISSION ON NOMENCLATURE, PROPERTIES, AND UNITS (C-NPU)§ PROPERTIES AND UNITS IN THE CLINICAL LABORATORY SCIENCES PART XII. PROPERTIES AND UNITS IN CLINICAL PHARMACOLOGY AND TOXICOLOGY (Technical Report) (IFCC–IUPAC 1999) Prepared for publication by HENRIK OLESEN1, DAVID COWAN2, RAFAEL DE LA TORRE3 , IVAN BRUUNSHUUS1, MORTEN ROHDE1, and DESMOND KENNY4 1Office of Laboratory Informatics, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; 2Drug Control Centre, London University, King’s College, London, UK; 3IMIM, Dr. Aiguader 80, Barcelona, Spain; 4Dept. of Clinical Biochemistry, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12, Ireland #§The combined Memberships of the Committee and the Commission (C-NPU) during the preparation of this report (1994–1996) were as follows: Chairman: H. Olesen (Denmark, 1989–1995); D. Kenny (Ireland, 1996); Members: X. Fuentes-Arderiu (Spain, 1991–1997); J. G. Hill (Canada, 1987–1997); D. Kenny (Ireland, 1994–1997); H. Olesen (Denmark, 1985–1995); P. L. Storring (UK, 1989–1995); P. Soares de Araujo (Brazil, 1994–1997); R. Dybkær (Denmark, 1996–1997); C. McDonald (USA, 1996–1997). Please forward comments to: H. Olesen, Office of Laboratory Informatics 76-6-1, Copenhagen University Hospital (Rigshospitalet), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. E-mail: [email protected] Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment, with full reference to the source, along with use of the copyright symbol ©, the name IUPAC, and the year of publication, are prominently visible. -
Central Valley Toxicology Drug List
Chloroform ~F~ Lithium ~A~ Chlorpheniramine Loratadine Famotidine Acebutolol Chlorpromazine Lorazepam Fenoprofen Acetaminophen Cimetidine Loxapine Fentanyl Acetone Citalopram LSD (Lysergide) Fexofenadine 6-mono- Clomipramine acetylmorphine Flecainide ~M~ Clonazepam a-Hydroxyalprazolam Fluconazole Maprotiline Clonidine a-Hydroxytriazolam Flunitrazepam MDA Clorazepate Albuterol Fluoxetine MDMA Clozapine Alprazolam Fluphenazine Medazepam Cocaethylene Amantadine Flurazepam Meperidine Cocaine 7-Aminoflunitrazepam Fluvoxamine Mephobarbital Codeine Amiodarone Fosinopril Meprobamate Conine Amitriptyline Furosemide Mesoridazine Cotinine Amlodipine Methadone Cyanide ~G~ Amobarbital Methanol Cyclobenzaprine Gabapentin Amoxapine d-Methamphetamine Cyclosporine GHB d-Amphetamine l-Methamphetamine Glutethamide l-Amphetamine ~D~ Methapyrilene Guaifenesin Aprobarbital Demoxepam Methaqualone Atenolol Desalkylfurazepam ~H~ Methocarbamol Atropine Desipramine Halazepam Methylphenidate ~B~ Desmethyldoxepin Haloperidol Methyprylon Dextromethoraphan Heroin Metoclopramide Baclofen Diazepam Hexobarbital Metoprolol Barbital Digoxin Hydrocodone Mexiletine Benzoylecgonine Dihydrocodein Hydromorphone Midazolam Benzphetamine Dihydrokevain Hydroxychloroquine Mirtazapine Benztropine Diltiazem Hydroxyzine Morphine (Total/Free) Brodificoum Dimenhydrinate Bromazepam ~N~ Diphenhydramine ~I~ Bupivacaine Nafcillin Disopyramide Ibuprofen Buprenorphine Naloxone Doxapram Imipramine Bupropion Naltrexone Doxazosin Indomethacin Buspirone NAPA Doxepin Isoniazid Butabarbital Naproxen -
DOCUMENT RESUME ED 300 697 CG 021 192 AUTHOR Gougelet, Robert M.; Nelson, E. Don TITLE Alcohol and Other Chemicals. Adolescent A
DOCUMENT RESUME ED 300 697 CG 021 192 AUTHOR Gougelet, Robert M.; Nelson, E. Don TITLE Alcohol and Other Chemicals. Adolescent Alcoholism: Recognizing, Intervening, and Treating Series No. 6. INSTITUTION Ohio State Univ., Columbus. Dept. of Family Medicine. SPONS AGENCY Health Resources and Services Administration (DHHS/PHS), Rockville, MD. Bureau of Health Professions. PUB DATE 87 CONTRACT 240-83-0094 NOTE 30p.; For other guides in this series, see CG 021 187-193. AVAILABLE FROMDepartment of Family Medicine, The Ohio State University, Columbus, OH 43210 ($5.00 each, set of seven, $25.00; audiocassette of series, $15.00; set of four videotapes keyed to guides, $165.00 half-inch tape, $225.00 three-quarter inch tape; all orders prepaid). PUB TYPE Guides - Classroom Use - Materials (For Learner) (051) -- Reports - General (140) EDRS PRICE MF01 Plus Plstage. PC Not Available from EDRS. DESCRIPTORS *Adolescents; *Alcoholism; *Clinical Diagnosis; *Drug Use; *Family Problems; Physician Patient Relationship; *Physicians; Substance Abuse; Units of Study ABSTRACT This document is one of seven publications contained in a series of materials for physicians on recognizing, intervening with, and treating adolescent alcoholism. The materials in this unit of study are designed to help the physician know the different classes of drugs, recognize common presenting symptoms of drug overdose, and place use and abuse in context. To do this, drug characteristics and pathophysiological and psychological effects of drugs are examined as they relate to administration, -
Introduced B.,Byhansen, 16
LB301 LB301 2021 2021 LEGISLATURE OF NEBRASKA ONE HUNDRED SEVENTH LEGISLATURE FIRST SESSION LEGISLATIVE BILL 301 Introduced by Hansen, B., 16. Read first time January 12, 2021 Committee: Judiciary 1 A BILL FOR AN ACT relating to the Uniform Controlled Substances Act; to 2 amend sections 28-401, 28-405, and 28-416, Revised Statutes 3 Cumulative Supplement, 2020; to redefine terms; to change drug 4 schedules and adopt federal drug provisions; to change a penalty 5 provision; and to repeal the original sections. 6 Be it enacted by the people of the State of Nebraska, -1- LB301 LB301 2021 2021 1 Section 1. Section 28-401, Revised Statutes Cumulative Supplement, 2 2020, is amended to read: 3 28-401 As used in the Uniform Controlled Substances Act, unless the 4 context otherwise requires: 5 (1) Administer means to directly apply a controlled substance by 6 injection, inhalation, ingestion, or any other means to the body of a 7 patient or research subject; 8 (2) Agent means an authorized person who acts on behalf of or at the 9 direction of another person but does not include a common or contract 10 carrier, public warehouse keeper, or employee of a carrier or warehouse 11 keeper; 12 (3) Administration means the Drug Enforcement Administration of the 13 United States Department of Justice; 14 (4) Controlled substance means a drug, biological, substance, or 15 immediate precursor in Schedules I through V of section 28-405. 16 Controlled substance does not include distilled spirits, wine, malt 17 beverages, tobacco, hemp, or any nonnarcotic substance if such substance 18 may, under the Federal Food, Drug, and Cosmetic Act, 21 U.S.C. -
Drug and Medication Classification Schedule
KENTUCKY HORSE RACING COMMISSION UNIFORM DRUG, MEDICATION, AND SUBSTANCE CLASSIFICATION SCHEDULE KHRC 8-020-1 (11/2018) Class A drugs, medications, and substances are those (1) that have the highest potential to influence performance in the equine athlete, regardless of their approval by the United States Food and Drug Administration, or (2) that lack approval by the United States Food and Drug Administration but have pharmacologic effects similar to certain Class B drugs, medications, or substances that are approved by the United States Food and Drug Administration. Acecarbromal Bolasterone Cimaterol Divalproex Fluanisone Acetophenazine Boldione Citalopram Dixyrazine Fludiazepam Adinazolam Brimondine Cllibucaine Donepezil Flunitrazepam Alcuronium Bromazepam Clobazam Dopamine Fluopromazine Alfentanil Bromfenac Clocapramine Doxacurium Fluoresone Almotriptan Bromisovalum Clomethiazole Doxapram Fluoxetine Alphaprodine Bromocriptine Clomipramine Doxazosin Flupenthixol Alpidem Bromperidol Clonazepam Doxefazepam Flupirtine Alprazolam Brotizolam Clorazepate Doxepin Flurazepam Alprenolol Bufexamac Clormecaine Droperidol Fluspirilene Althesin Bupivacaine Clostebol Duloxetine Flutoprazepam Aminorex Buprenorphine Clothiapine Eletriptan Fluvoxamine Amisulpride Buspirone Clotiazepam Enalapril Formebolone Amitriptyline Bupropion Cloxazolam Enciprazine Fosinopril Amobarbital Butabartital Clozapine Endorphins Furzabol Amoxapine Butacaine Cobratoxin Enkephalins Galantamine Amperozide Butalbital Cocaine Ephedrine Gallamine Amphetamine Butanilicaine Codeine -
Practitioners Guide for Medications in Alcohol and Drug Dependence
PRACTITIONERS GUIDE FOR MEDICATIONS IN ALCOHOL AND DRUG DEPENDENCE INTRODUCTION It is likely the majority of chemically dependent persons will probably need medications (including both prescriptions and over-the counter) at some point in their recovery. At any time, such medications should only be taken as prescribed by their primary physician in conjunction with their addiction specialist. This Guide is intended to serve as a resource for the recovering chemically dependent person and the medical professional prescribing treatment. It is not meant to be used exclusively or as the sole means for providing advice regarding medications. Indeed, this Guide would be best utilized in conjunction with other concurrent reference materials. Decisions about particular prescription medication(s) should be tailored to the needs of the individual patient under the direction of a health professional. This Guide is not intended to be exhaustive, nor an endorsement of any particular brand name medication. Rather it is intended to provide relevant pharmacological information to the recovering person and health care providers treating those in recovery. GUARDING AGAINST ADDICTION Recovering alcoholics and addicts must be constantly alert to the possibility of triggering a relapse of their disease through the intake of drugs or alcohol. Just as a diabetic needs to be cautious about the intake of sugar, the recovering alcoholic must be sensitive to drugs and the recovering addict must be sensitive to alcohol, and both must be sensitive to other mood-altering drugs, including prescribed and over-the-counter preparations. This Guide is designed to serve as a resource when making decisions regarding what medication(s) to take, as well as a reference tool for those who prescribe medication for persons in recovery. -
Barbiturates
URINE DRUG TEST INFORMATION SHEET BARBITURATES Classification: Central nervous system depressants insomnia, anxiety or tension due to their very high (CNS Depressants) risk of physical dependence and fatal overdose. Due to the structural nature of barbiturates, the duration Background: Barbiturates are a group of drugs of action does not always correlate well with the that act as central nervous system depressants. biological half-life. Opiates, benzodiazepines and alcohol are also CNS depressants, and like their use, the effect seems to Physiological Effects: Lowered blood pressure, the user as an overall sense of calm. Barbiturates respiratory depression, fatigue, fever, impaired were introduced in 1903, dominating the sedative- coordination, nystagmus, slurred speech and ataxia hypnotic market for the first half of the twentieth century. Unfortunately, because barbiturates have Psychological Effects: Drowsiness, dizziness, unusual a relatively low therapeutic-to-toxic index and excitement, irritability, poor concentration, sedation, substantial potential for abuse, they quickly became confusion, impaired judgment, addiction, euphoria, a major health problem. Barbiturates are commonly decreased anxiety and a loss of inhibition abused for their sedative properties and widespread Toxicity: Barbiturates are especially more availability. The introduction of benzodiazepines in dangerous when abused with alcohol, opiates and the 1960s quickly supplanted the barbiturates due benzodiazepines because they act on the same to their higher safety -
Drugs of Abuse Screens 5,6,9 – Detection Limits
Drugs of Abuse Screens 5,6,9 – Detection limits Amphetamines low detection limit Benzodiazepines low detection limit d-Amphetamine 1286 ng/mL Alprazolam 65 ng/mL d,I-Amphetamine 2139 ng/mL 7-aminoclonazepam 2600 ng/mL d-Methamphetamine 1000 ng/mL 7-aminoflunitrazepam 590 ng/mL d,I-Methamphetamine 1564 ng/mL Bromazepam 630 ng/mL I-Amphetamine 10407 ng/mL Chlordiazepoxide 3300 ng/mL I-Methamphetamine 2273 ng/mL Clobazam 260 ng/mL Methylenedioxyamphetamine (MDA) 3537 ng/mL Clonazepam 580 ng/mL Methylenedioxymethamphetamine (MDMA) 20538 ng/mL Clotiazepam 380 ng/mL Methylenedioxyethylamphetamine (MDEA) 18230 ng/mL Demoxepam 1600 ng/mL 4-Chloramphetamine 10 µg/mL N-Desalkylflurazepam 130 ng/mL Benzphetamine 1 µg/mL N-Desmethyldiazepam 110 ng/mL Bupropion 1038 µg/mL Diazepam 70 ng/mL Chloroquine 3741 µg/mL Estazolam 90 ng/mL I-Ephedrine 2242 µg/mL Flunitrazepam 140 ng/mL Fenfluramine 105 µg/mL Flurazepam 190 ng/mL Mephentermine 30 µg/mL Halazepam 110 ng/mL Methoxypenamine 331 µg/mL α-Hydroxyalprazolam 100 ng/mL Nor-pseudoephedrine 188 µg/mL 1-N-Hydroxyethylflurazepam 150 ng/mL Phenmetrazine 9 µg/mL α-Hydroxytriazolam 130 ng/mL Phentermine 21 µg/mL Ketazolam 100 ng/mL Phenylpropanolamine (PPA) 133 µg/mL Lorazepam 600 ng/mL Propranolol 386 µg/mL Lormetazepam 200 ng/mL Pseudoephedrine 5889 µg/mL Medazepam 150 ng/mL Quinacrine 8293 µg/mL Midazolam 130 ng/mL Tranylcypromine 126 µg/mL Nitrazepam 320 ng/mL Tyramine 503 µg/mL Norchlordiazepoxide 2600 ng/mL Barbiturates low detection limit Oxazepam 250 ng/mL Allobarbital 345 ng/mL Prazepam 90 ng/mL Alphenal -
Substance Abuse Among Older Adults: an Invisible Epidemic
1 Substance Abuse Among Older Adults: An Invisible Epidemic ubstance abuse, particularly of alcohol use and misuse of substances, along with a and prescription drugs, among adults 60 reluctance to seek professional help for what S and older is one of the fastest growing many in this age group consider a private health problems facing the country. Yet, even as matter. Many relatives of older individuals with the number of older adults suffering from these substance use disorders, particularly their adult disorders climbs, the situation remains children, are also ashamed of the problem and underestimated, underidentified, choose not to address it. Ageism also contributes underdiagnosed, and undertreated. Until to the problem and to the silence: Younger relatively recently, alcohol and prescription adults often unconsciously assign different drug misuse, which affects up to 17 percent of quality-of-life standards to older adults. Such older adults, was not discussed in either the attitudes are reflected in remarks like, substance abuse or the gerontological literature “Grandmother’s cocktails are the only thing that (D’Archangelo, 1993; Bucholz et al., 1995; makes her happy,” or “What difference does it National Institute on Alcohol Abuse and make; he won’t be around much longer Alcoholism, 1988; Minnis, 1988; Atkinson, 1987, anyway.” There is an unspoken but pervasive 1990). assumption that it’s not worth treating older Because of insufficient knowledge, limited adults for substance use disorders. Behavior research data, and hurried office visits, health considered a problem in younger adults does care providers often overlook substance abuse not inspire the same urgency for care among and misuse among older adults. -
Forensic Toxicology Scope of Testing and Detection Limits
J. RYAN MCMAHON II County Executive INDU GUPTA, MD, MPH MEDICAL EXAMINER’S OFFICE Commissioner of Health FORENSIC TOXICOLOGY LABORATORY CAROLYN H. REVERCOMB, MD, DABP ONONDAGA COUNTY HEALTH DEPARTMENT Chief Medical Examiner KRISTIE BARBA, MS, D-ABFT-FT CENTER FOR FORENSIC SCIENCES Toxicologist Forensic Toxicology Scope of Testing and Detection Limits Table of Contents QUALITATIVE ANALYSES.........................................................................................................2 Volatile Screen by GC/FID .............................................................................................................2 Carbon Monoxide by Microdiffusion..............................................................................................2 Carbon Monoxide by CO-Oximeter ................................................................................................2 Ethylene Glycol by GC/MS.............................................................................................................2 ELISA Buprenorphine by IA for Blood/Urine ................................................................................2 ELISA by IA for Blood ...................................................................................................................3 ELISA by IA for Urine....................................................................................................................4 Gamma Hydroxybutyrate (GHB) by GC/MS..................................................................................5 Gabapentin, -
Laws 2021, LB236, § 4
LB236 LB236 2021 2021 LEGISLATIVE BILL 236 Approved by the Governor May 26, 2021 Introduced by Brewer, 43; Clements, 2; Erdman, 47; Slama, 1; Lindstrom, 18; Murman, 38; Halloran, 33; Hansen, B., 16; McDonnell, 5; Briese, 41; Lowe, 37; Groene, 42; Sanders, 45; Bostelman, 23; Albrecht, 17; Dorn, 30; Linehan, 39; Friesen, 34; Aguilar, 35; Gragert, 40; Kolterman, 24; Williams, 36; Brandt, 32. A BILL FOR AN ACT relating to law; to amend sections 28-1202 and 69-2436, Reissue Revised Statutes of Nebraska, and sections 28-401 and 28-405, Revised Statutes Cumulative Supplement, 2020; to redefine terms, change drug schedules, and adopt federal drug provisions under the Uniform Controlled Substances Act; to provide an exception to the offense of carrying a concealed weapon as prescribed; to define a term; to change provisions relating to renewal of a permit to carry a concealed handgun; to provide a duty for the Nebraska State Patrol; to eliminate an obsolete provision; to harmonize provisions; and to repeal the original sections. Be it enacted by the people of the State of Nebraska, Section 1. Section 28-401, Revised Statutes Cumulative Supplement, 2020, is amended to read: 28-401 As used in the Uniform Controlled Substances Act, unless the context otherwise requires: (1) Administer means to directly apply a controlled substance by injection, inhalation, ingestion, or any other means to the body of a patient or research subject; (2) Agent means an authorized person who acts on behalf of or at the direction of another person but does not include a common or contract carrier, public warehouse keeper, or employee of a carrier or warehouse keeper; (3) Administration means the Drug Enforcement Administration of the United States Department of Justice; (4) Controlled substance means a drug, biological, substance, or immediate precursor in Schedules I through V of section 28-405. -
(12) Patent Application Publication (10) Pub. No.: US 2003/0198664 A1 Sullivan Et Al
US 2003O198664A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2003/0198664 A1 Sullivan et al. (43) Pub. Date: Oct. 23, 2003 (54) LIPID MEDIATED SCREENING OF DRUG Publication Classification CANDDATES FOR IDENTIFICATION OF ACTIVE COMPOUNDS (51) Int. Cl." ......................... C12Q 1/68; G01N 33/574; A61K 9/127; C12N 15/88 (76) Inventors: Sean Michael Sullivan, Gainesville, FL (52) U.S. Cl. ............................. 424/450; 435/6; 435/723; (US); Robert A. Copeland, Hockessin, 435/.458 DE (US) Correspondence Address: (57) ABSTRACT SALIWANCHIK LLOYD & SALWANCHIK A PROFESSIONAL ASSOCATION The Subject invention provides lipoSome formulations that 2421 N.W. 41ST STREET are capable of Specifically targeting cell types. The Subject SUTE A-1 invention also provides for the encapsulation of new chemi GAINESVILLE FL 326066669 cal entities (NCE) or other drug candidate molecules (DCM) 9 within liposomes that Specifically target a particular cell (21) Appl. No.: 10/404,896 type. The Subject invention, advantageously, Solubilizes compounds, with low Solubility in aqueous environments, (22) Filed: Mar. 31, 2003 and permits Screening of these compounds against intact cells for biological activity in the absence of detergents that Related U.S. Application Data can damage cell membranes. Also provided are methods of preparing liposome formulations that target a specific cell (60) Provisional application No. 60/368,529, filed on Mar. type and methods of delivering therapeutic agents to target 29, 2002. cells. US 2003/O198664 A1 Oct. 23, 2003 LPD MEDIATED SCREENING OF DRUG (DCM) within liposomes that specifically target a particular CANDDATES FOR IDENTIFICATION OF ACTIVE cell type. The Subject invention, advantageously, Solubilizes COMPOUNDS compounds, with low Solubility in aqueous environments, and permits Screening of these compounds against intact CROSS-REFERENCE TO RELATED cells for biological activity in the absence of detergents that APPLICATION can damage cell membranes.