(12) United States Patent (10) Patent No.: US 6,387,890 B1 Christianson Et Al
USOO638789OB1 (12) United States Patent (10) Patent No.: US 6,387,890 B1 Christianson et al. (45) Date of Patent: May 14, 2002 (54) COMPOSITIONS AND METHODS FOR CA:87:6321 abs of Diss Abstr Int B 37(8) pp. 3927-8 by INHIBITING ARGINASE ACTIVITY Hartz. Albina et al., 1995, J. Immunol. 155:4391-4396. (75) Inventors: David Christianson, Media, PA (US); Bacon et al., 1988, J. Mol. Graph. 6:219–200. Ricky Baggio, Waltham; Daniel Baker et al., 1980, Fed. Proc., Fed. Am. Soc. Exp. Biol. Elbaum, Newton, both of MA (US) 39:1686. Baker et al., 1983, Biochemistry 22:2098-2103. (73) Assignee: Trustees of the University of Bergeron et al., 1987, J. Org. Chem. 52:1700–1703. Pennsylvania, Philadelphia, PA (US) Biancani et al., 1985, Gastroenterology 89:867-874. - 0 Boden, 1975, Synthesis 784. (*) Notice: Subject to any disclaimer, the term of this Boucher et al., 1994, Biochem. Biophys. Res. Commun. patent is extended or adjusted under 35 2O3:1614-1621. U.S.C. 154(b) by 0 days. Bringer et al., 1987, Science 235:458–460. Bringer et al., 1998, Acta Crystallogr. D54:905-921. (21) Appl. No.: 09/545,737 Campos et al., 1995, J. Biol. Chem. 270:1721–1728. Cavaili et al., 1994, Biochemistry 33:10652–10657. (22) Filed: Apr. 10, 2000 Chakder and Rattan, 1997, J. Pharmacol. Exp. Ther. 282:378-384. Related U.S. Application Data Chakder and Rattan, 1993, Am. J. Physiol. Gastrointest. (63) Continuation-in-part of application No. PCT/US98/21430, Liver Physiol. 264:G7-G12. filed on Oct.
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