JORGE C. PAradelo, M.D., F.A.C.R.

CURRICULUM VITAE

PRESENT/PAST AFFILIATIONS:

Therapeutic Radiologists, Inc. 6601 Winchester, Suite 230 -Kansas City, Missouri, 64133 September 1981- July 2006

UNDERGRADUATE EDUCATION:

Colegio Secundario "J.J. de Urquiza" Concepcion del Uruguay, Argentina Bachiller Comercial Degree 1959-1963

MEDICAL EDUCATION:

Facultad de Medicina, Universidad de Rosario Rosario, Santa Fe, Argentina Physician 1964- 1971

TRAINING &EXPERIENCE:

Radiation Oncology Consultant. July 2006 – Present

Radiation Oncologist and Assistant Professor Cancer Research and Treatment Center University of New Mexico –Albuquerque, New Mexico July 1979 to August 1981

Medical Officer of the Day Veteran's Administration Hospital Bedford, Massachusetts May 1976 to June 1979

Chief Resident - Therapeutic Radiology Tufts-New England Medical Center Boston, Massachusetts – July 1978 to June 1979

CURRICULUM VITAE - Jorge C. PAradelo, M.D.

TRAINING & EXPERIENCE: (continued:)

Assistant Physician in Medicine Peter Bent Brigham Hospital - Boston, Massachusetts September 1975 to June 1979

Resident in Therapeutic Radiology Tufts-New England Medical Center - Boston, Massachusetts July 1975 to June 1978

Medical Internship Lemmuel Shattuck and Faulkner Hospitals - Boston, Massachusetts April 1974 to June 1975

Physician in Charge Emergency Room - Somisa (Foundry, daily census: 10,000 employees) San Nicolas, Argentina July 1971 to March 1974

Post Doctoral Fellowship in Pathology -Department of Pathology Facultad de Medicina - Rosario, Argentina June 1973 to March 1974

OB/GYN Service J.M. Fernandez Hospital Facultad de Medicina - Rosario, Argentina December 1970 to April 1971

Internship in Medicine J.M. Fernandez Hospital Facultad de Medicina - Rosario, Argentina August 1970 to September 1971

Research Fellow in Pharmacology Facultad de Medicina - Rosario, Argentina March 1968 to August, 1970

Instructor of Anatomy Facultad de Medicina - Rosario, Argentina

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 2 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

June 1965 to June 1966

BOARD CERTIFICATON & PROFFESIONAL LICENSURE:

Visa Qualifying Examination, USA, 1977

Federal Licensing Examination, USA, 1975

Educational Council for Foreign Medical Graduates, USA, 1972

Unlimited License to Practice Medicine, Rosario, Argentina, 1972

Unlimited License to Practice in the State of Massachusetts,

American Board of Radiology (Therapeutic Radiology), USA, 1978

Licensed to practice medicine in Missouri, Kansas and New Mexico

APPOINTMENTS:

Clinical Assistant Professor University of Kansas Medical Center, July 1990 to Present

Clinical Associate Professor University of Missouri at Kansas City, July 1983 to July 2005

Assistant Professor of Radiology Cancer Research and Treatment Center University of New Mexico - Albuquerque, New Mexico July 1979 to August 1981

HONORS AND AWARDS:

Graduated in Top Ten of Class (150) Fellow, American College of Radiology

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 3 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

SOCIETIES AND ORGANIZATIONAL MEMBERSHIPS: Present American Society of Therapeutic Radiologists American Medical Association American College of Radiology

Past Jackson County Medical Society Missouri State Medical Association New Mexico Medical Society Radiation Oncology Group (RTOG) Southwest Oncology Group, Committee on Women's Health Kansas City Clinical Oncology Program; Principal Investigator Board of Governors, South West Oncology Group Chairman, Normal Tissue Tolerance Committee, Southwest Oncology Group Southwest Oncology Group Urology Committee – Radiotherapy Chair Protocol Coordinator: SWOG 8221 and SWOG 8794 RTOG Committee for Quality Control Missouri Radiological Society, Committee 1994 Metropolitan Medical Society, International Physicians Task Force 1994

HOSPITAL ADMINISTRATIVE APPOINTMENTS: Past President, Research Physicians Comprehensive Health Care Principal Investigator, Kansas City Community Oncology Program, - KC, KS Member, Cancer Committee, Research Medical Center Medical Director, Department of Radiation Oncology, Research Medical Center – KC, MO Member, Advisory Board, Select Cost Effectiveness Analysis (SELECT-CEA) Member, Lovelace Clinic, Oncology Committee Member, UNMH, Oncology Committee Member, Research Medical Center, Radiation Safety Committee Member, Baptist Medical Center Oncology Committee Medical Director, Center for Radiation Therapy Baptist Medical Center - KC, MO

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 4 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

Member, Humana Hospital Oncology Committee HOSPITAL ADMINISTRATIVE APPOINTMENTS: Past (continued:)

Member, Research Medical Center, Oncology Committee Vice Chairman, “Ensure The Dream Campaign” Baptist Medical Center- KC, MO Member, Research Medical Center Education Commission, 1996 Member, St. Joseph Hospital Oncology Committee Member, Baptist Medical Center, DRG Committee Chairman, Education Committee – Research Medical Center

OTHER ADMINISTRATIVE APPOINTMENTS:

Vice President: Therapeutic Radiologists, Inc. Consultant: Genentech, Inc., San Francisco, CA Member: Board of Directors, American Cancer Society, KCMO Unit Member: Board of Directors, Kansas City Comets

PUBLICATIONS:

1. Munzenrider, J., M.D.; Tchakarova, I., M.D.; Necheles, T.; Oh, W.H., M.D.; Banks, H., M.D.; and Paradelo, J.C., M.D.: Combined Therapy of Osteosarcoma Preoperative Irradiation, Surgery and Chemotherapy, Radiology, November, 1977.

2. Paradelo, J.C., M.D.; Mower, H., Sc.D.; and Ucmakli, A., M.D.: The Effects of Radiotherapy Technique on the Spinal Cord in Head and Neck Cancer Patients. Abstracts, Published in Proceedings of the American Radium Society Meeting, April, 1978.

3. Ross, W., M.S.; and Paradelo, J.C., M.D.: Electron Therapy in Carcinoma of the Breast. Presented at the Annual Meeting of the American Radium Society, March 5, 1979. Los Angeles. 4. Paradelo, J.C., M.D.; Ucmakli, a., M.D.; Schiller, B., Ph.D.; Sternick, E., Ph.D; Mower, H., Sc.D: Mid-Sagittal Plain in Patients with Extensive Head and Neck Malignancies. Int. Journal Radiation Oncology, Biol., Physics, Vol. 7, 1980.

5. Bagshaw, M., M.D.; Khan, M., M.D.; and Paradelo, J.C., M.D.: Radiation Therapy in the Treatment of Urological Cancer: "Genito-Urinary Cancer Surgery," Crawford and Borden, editors, Lea and Febiger. Philadelphia, 1982.

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 5 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

PUBLICATIONS: (continued:)

6. Paradelo, J.C., M.D.; Dukstein, W.C., M.D.; Stabb, J.E., M.D.; Morgan, R.A., M.S.: Curative Radiotherapy and COPD, Prediction of Lung Tolerance, Abstract #274 in Proceedings of Radiological Society of North America. November 1983.

7. Smith, J.E.; Crawford, E.D.; Paradelo, J.C.; Sullivan, J.; Montie, J.; and Grossman, B. A Randomized Study of Preoperative Irradiation Plus Radical Cystectomy Versus Surgery Alone for Transitional Cell Carcinoma of the Bladder, A Southwest Oncology Group Study. Abstract in Proceedings of AUA 83rd Annual Meeting, Journal of Urology, Vol. 139, 266A.

8. Griffin, J.F.; Hassanein, R.E.S.; Jewell, W.; Paradelo, J.C.; Reymond, R.D; Smalley, S.R; and Evans, R.G.;.: Patterns of Failure Following Curative Resection of Pancreatic Carcinoma. CANCER Vol. 66, No. 1, July 1, 1990.

9. Russell, A.H.; Pajak, T.E.; Selim, H.M.; Paradelo, J.C.; Murray, K.; Bansal, P; Cooper, J.D.; Silverman, S.; Clement, J.A.: Prophylactic Cranial Irradiation for Lung Cancer Patients at High Risk for Development of Cerebral Metastasis: Results of a Prospective Randomized Trial Conducted by the Radiation Therapy Oncology Group. Int. J. Radiation Oncology Biol. Phys., Vol 21 pp 637-643. February 22, 1991.

10. Thompson, I.; Crawford, E.D.,; Miller, G.; Paradelo, J.C.; Blumenstein, B.; Wolfe, M.; Moinpour, C.; Hayden, K.; Messing, E.: Adjuvant Radiotherapy following Radical Prostatectomy for Pathologic Stage C Adenocarcinoma of the Prostate; Initial Evaluation of Toxicity. Submitted for presentation to ASCO, 1992.

11. Paradelo, J.C.; Waxman, M.J.; Throne, B.J.; Beller, T.A.; Kopecky, W.J., Ph.D.: Endobronchial Irradiation with 912 Ir in the Treatment of Malignant Endobronchial Obstruction. Chest, 1992-102-1072-74.

12. Nigh, S.S.; Smalley, S.R.; Elman, A.J.; Paradelo, J.C.; Koser, J.A.; Raghunath, R.; Evans, R.G.: Conservative Therapy for Anal Carcinoma: An Analysis of Progostic Factors. Abstract presented at American Society for Therapeutic Radiology and Oncology, 1992.

13. Thompson, I.M.; Paradelo, J.C.; Crawford, E.D.; Coltman, C.A.; Blumenstein, B.: An Opportunity to Determine Optimal Treatment of pT3 Prostate Cancer: The Window May Be Closing. Urology, 12/94. Vol. 44, No. 6.

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 6 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

PUBLICATIONS: (continued:)

14. Smith, J.A., Jr.; Blumenstein, B.; Paradelo, J.C.; Herscham, B.R.; Thigpen, J.T.; Samlowski, W.; ingh, K.P.; Grossman, H.B.; Christie, D.W.; Crawford, E.D: Treatment of Advanced Bladder Cancer with Combined Preoperative, Irradiation and Radical Cystectomy versus Radical Cystectomy Alone:A Phase III Intergroup Study, The Journal of Urology, Vol. 157, pp. 805-808, March 1997

15. Gordon, W.G.,Jr; Siegmund, K.; Stanisic, T.; McKnight, B.; Harris, I.T.; Carroll, Peter R.; Paradelo, J.C.; Meyers, F.J.; Chapman, R.A.; Meyskens, F.L.: A Study of Reproductive Function in Patients with Seminoma Treated with Radiotherapy and Orchidectomy: International Journal Radiation Oncology Biology Physics,Vol. 38 pp. 83-94, November 1997 .

16. Taylor, C.W., Paradelo, J.C.: A Multi-Center Randomized Clinical Trial of Goserelin Versus Surgical Ovariectomy in Pre-Menopausal Patients with Receptor Positive Metastatic Breast Cancer: An Intergroup Study: Journal of Clinical Oncology, Vol. 16, No. 3, pp. 994-999, March, 1998.

17. J.C. Paradelo, J. Montie, M. Roach III: Review of “Therapeutic Radiation in Patients With a Rising Post-Prostatectomy PSA Level”: Oncology, Vol. 12, Number 1, pp. 43-44, January 1998.

18. Therapeutic Radiation in Patients With a Rising Post-Prostatectomy PSA Level by Jeffrey D. Forman, Joaquin Velasco-Reviewed by J.C. Paradelo; J. Montie; M. Roach III. Oncology, January 1998, Vol. 12, Num. 1, pp. 43-44.

19. G.K Ellis, S. Green, R.B. Livingston, M.J. Kraut, H.I. Pierce, J.C. Paradelo, S.A. Taylor, S. Martino.: "Neo-FAC" (5-Flourouracil, Doxorubin and Cyclophosphamide) for Poor Prognosis Stage IV Breast Cancer: a Southwest Oncology Group Phase II Study. American Journal of Clinical Oncology 22(5):446-449, 1999.

20. S. Urba, S. Taylor, J. Paradelo, J. Abbruzzese, K. Chansky, “Gemcitabine and Cisplatin Chemotherapy for Patients with Metastatic Esophageal Carcinoma”, Southwest Oncology Group, European Journal of Cancer, Vol. 37, Suppl. 6, October 2001, page 287.

21. T. Rich, J. Harris, R. Abrams, B. Erickson, M. Doherty, J. Paradelo, W. Small Jr, H. Safran, H.J. Wanebo. “Phase II Study of External Irradiation and Weekly Paclitaxel for

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 7 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

Nonmetastatic Unresectable Pancreatic Cancer: RTOG 98-12. American Journal of Clinical Oncology. 27(1):51-6. Februay 2004. PUBLICATIONS: (continued:) 22. S.K. Williamson, S.A. McCoy, D.R. Gandara, S.R. Dakhil, K.J. Yost, J.C. Paradelo, J.N.Atkins, C.D. Blanke, J.L. Abruzzese. Phase II Trial of Gemcitabine Plus Irinotecane in Patients with Esophageal Cancer: A Southwest Oncology Group (SWOG) Trial. American Journal of Clinical Oncology. 29(2):116-22. April 2006.

23. I.M. Thompson Jr., C.M. Tangen, J.C. Paradelo, M.S. Lucia, G. Miller, D. Troyer, E. Messing, J. Forman, J. Chin, G. Swanson, E. Canby-Hagino, E.D. Crawford. “Adjuvant Radiotherapy for Pathologically Advanced Prostate Cancer: A Randomized Clinical Trial” JAMA, 296(19): 2329-35. Nov. 15 2006.

24. Ian M. Thompson, Catherinne M. Tangen, Jorge Paradelo, “Adjuvant Radiotherapy for Pathological T3NOMO Prostate Cancer Significantly Reduces Risk of Metastases and Improves Survival: Long-Term Followup of a Randomized Clinical Trial”, The Journal of Urology, Vol. 181, 956-962 March 2009.

POSTER SESSIONS, PRESENTATIONS, DISSERTATIONS:

May 2004 Skull Base Meningioma: The Midwest Gamma Knife Experience J.C. Paradelo, MD, FACR and J. Chilton, MD, MPH, Poster Presentation at International Gamma Knife meeting in Vienna, Austria

October 2002 Research Medical Center Advisory Directors “The Use of a CT Scanner For The Treatment of Cancer”

November 2001 St. Luke’s Hospital, Medical Ground Rounds, “Alternatives in Stereotactic Radiation”

June, 1998 Cancer 1998 – Program Director Ed Bixby Institute for Medical Education, Kansas City, MO

July, 1996 Bloch Cancer Hot Line Home Volunteer Training Session - Speaker, R.A. Bloch Cancer Foundation, Kansas City, MO

April, 1996 Missouri Society of Radiologic Technologists, Gamma Knife – Speaker, Kansas City, MO

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 8 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

November, 1994 "The Gamma Knife - The Who, What, When, Where, Why and How", 72nd Annual Fall Clinical Conference - Kansas City Southwest Clinical Society, Westin Crown Center, KC , MO. POSTER SESSIONS, PRESENTATIONS, DISSERTATIONS: (continued:)

October 1994 "The Gamma Knife" St John's Regional Medical Center, Joplin, MO

April 1994 Presentation of Normal Tissue Tolerance to Chemo - Radiation, Crila, 1994 Buenos Aires, Argentina

April 1994 in the Management of Recurrent Carcinoma of the Lung, Crila, 1994, Buenos Aires, Argentina

December 1993 Oncology Lecture - The Use of Radiation in the Treatment of Prostate Cancer, R.A. Bloch Cancer Support, Kansas City, MO.

October 1993 ESTRO Teaching Course on "The Role of Radiotherapy in the Management of Cancer", Prague, Czech Republic.

September 1993 I Can Cope Educational Program lecture on "Living with Cancer & Learning More About It", sponsored by American Cancer Society & St. Joseph Health Center, Kansas City, MO.

October 1992 Oncology Lecture-Radiation Therapy and Lung Cancer, University of Health Sciences, Kansas City, KS.

October 1992 Cancer Institute Planning Committee - Cancer Care Issues and Advances in the 1990's; Curry Auditorium, Baptist Medical Center, Kansas City, MO.

June 1992 Prostate Cancer Seminar-Moderator-Ed Bixby Institute for Postgraduate Medical Education, Research Medical Center, Kansas City, MO.

June 1992 Prostate Cancer Seminar - Speaker - Nonhormonal Options for Advanced Prostate Cancer. Ed Bixby Institute for Postgraduate Medical Education, Research Medical Center, Kansas City, MO.

November 1991 Oncology Lecture-Radiation Therapy and Lung Cancer, University of Health Sciences, Kansas City, KS. October 1991 1991 Ambassadors of Hope-American Cancer Society, Keynote Speaker, Kansas City, MO.

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 9 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

November 1990 Oncology Lecture - Lung Cancer and Radiation Therapy, University of Health Sciences; Kansas City, KS. POSTER SESSIONS, PRESENTATIONS, DISSERTATIONS: (continued:)

October 1989 Radiation Therapy in Cancer of the Larynx, Kansas City UAL Club, The American Cancer Society, Kansas City, MO.

September 1989 Advances in Radiation Therapy, Chillicothe, MO; Ed Bixby Institute for Postgraduate Medical Education. Research Medical Center, Kansas City, MO.

June 1989 Advances in Therapy for Bronchogenic Carcinoma: Chemotherapy, Brachy- therapy, and Laser Resection; Ed Bixby Institute for Postgraduate Medical Education. Research Medical Center, Kansas City, MO.

February 1989 Controversies in the Management of Carcinoma of the Breast: Ed Bixby Institute for Postgraduate Medical Education. Research Medical Center, Kansas City, MO.

January 1987 Presentation on Radiation Therapy; Patient Concerns and Treatment Options; Cancer Action, Inc., Kansas City, KS.

September 1985 Definitive Radiotherapy and Conservative Surgery for Cancer of the Breast, Humana Hospital, Overland Park, Kansas.

October 1984 Presentation to American Cancer Society, Kansas City, MO.

May 1993 Advances in Radiation Oncology, Cancer in Kansas, l983, Kansas City, MO.

March 1983 Advances in Radiation Oncology, Kansas Medical Society, 1983 Annual Meeting, Lawrence, Kansas.

January 1983 Radiation Therapy for the Cancer Patient, University of Missouri at Kansas City, School of Dentistry.

December 1982 Lumpectomy Plus Radiation Therapy -- ? An Alternative to Mastectomy, Ed Bixby Institute for Postgraduate Medical Education. Research Medical Center, Kansas City, MO.

6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 10 CURRICULUM VITAE - Jorge C. PAradelo, M.D.

October 1982 Dosimetry of Adjacent Fields in Head and Neck Radiation Therapy, Missouri Society of Radiologic Technology, Annual Meeting, Kansas City, MO.

March 1982 Radiation Therapy Conference, Research Medical Center. POSTER SESSIONS, PRESENTATIONS, DISSERTATIONS: (continued:)

October 1982 Dosimetry of Adjacent Fields in Head and Neck Radiation Therapy, Missouri Society of Radiologic Technology, Annual Meeting, Kansas City, MO.

March 1982 Radiation Therapy Conference, Research Medical Center.

March 1982 General Principles of Radiotherapy, University of Missouri at Kansas City, School of Dentistry.

March, 1982 Conservative Surgery Plus Radiotherapy in the Management of Breast Cancer, Research Medical Center, Kansas City, MO.

March 1982 Radiotherapy Management of Head and Neck Cancer, University of Missouri Kansas City School of Dentistry, Kansas City, MO.

November 1981 Radiation Therapy in Current Practice, Veterans Administration Hospital, Leaven-worth, Kansas.

April 1980 Dissertation on Inflammatory Breast Cancer; Excision, Irradiation and Implant for Breast Cancer. Annual Los Alamos Cancer Clinic Symposium. Los Alamos, New Mexico.

October 1979 Presented Poster on Spinal Cord Protection at 21st Annual Meeting of The American Society of Therapeutic Radiologists, New Orleans, LA.

September 1978 Dosimetry At The Abutting Line in Head and Neck Radiotherapy, New England Society of Radiation Oncology, Portland, Maine.

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6601 Winchester, Suite 230 • Kansas City, Missouri, 64133 • (816) 313-2677 11