Psychedelic Drugs and Jungian Therapy
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Introduction to Psychopharmacology
1 Introduction to Psychopharmacology CHAPTER OUTLINE • Psychopharmacology • Why Read a Book on Psychopharmacology? • Drugs: Administered Substances That Alter Physiological Functions • Psychoactive Drugs: Described by Manner of Use • Generic Names, Trade Names, Chemical Names, and Street Names for Drugs • Drug Effects: Determined by Dose • Pharmacology: Pharmacodynamics, Pharmacokinetics, and Pharmacogenetics • Psychoactive Drugs: Objective and Subjective Effects • Study Designs and the Assessment of Psychoactive Drugs • Validity: Addressing the Quality and Impact of an Experiment • Animals and Advancing Medical Research • Researchers Consider Many Ethical Issues When Conducting Human Research • From Actions to Effects: Therapeutic Drug Development • Chapter Summary sychoactive substances have made an enormous impact on society. Many people regularly drink alcohol or smoke tobacco. Millions of Americans take P prescribed drugs for depression or anxiety. As students, scholars, practitioners, and everyday consumers, we may find that learning about psychoactive substances can be invaluable. The chapters in this book provide a thorough overview of the Domajor not classes of psychoactive copy, drugs, including post, their actions inor the body distributeand their effects on behavior. 1 Copyright ©2018 by SAGE Publications, Inc. This work may not be reproduced or distributed in any form or by any means without express written permission of the publisher. 2 Drugs and the Neuroscience of Behavior Psychopharmacology Psychopharmacology Psychopharmacology is the study of how drugs affect mood, perception, think- Study of how drugs ing, or behavior. Drugs that achieve these effects by acting in the nervous system affect mood, perception, thinking, or behavior are called psychoactive drugs. The term psychopharmacology encompasses two large fields: psychology and pharmacology. Thus, psychopharmacology attempts to Psychoactive drugs Drugs that affect mood, relate the actions and effects of drugs to psychological processes. -
“An Opportune Moment in Time” Center for Jungian Studies of South Florida 2013 - 2014 Season
“AN OPPORTUNE MOMENT IN TIME” CENTER FOR JUNGIAN STUDIES OF SOUTH FLORIDA 2013 - 2014 SEASON “We are living in what the Greeks called the kairos—the right moment—for a ‘metamorphosis of the gods,’ of the fundamental principles and symbols.” C. G. Jung, The Undiscovered Self We live in a paradoxical and simultaneously opportune time. We have global awareness and the power to destroy the globe. We have knowledge of a multitude of religions and yet we are often spiritually bereft. It is a unique point in history, ripe for genuine transformation. Come join us as we explore Jung’s message that new principles and symbols are necessary, and as we examine what some of these might be. We do this all within a supportive, welcoming community of mental health professionals and others actively seeking personal awareness, exploration, and growth. Center for Jungian Studies of South Florida 2013–2014 Season “An Opportune Moment in Time” December 6 & 7, 2013 Friday: Reception begins at 6:30 pm Lecture 7:30 – 9:30 pm Saturday: Workshop 9:30 am – 4:30 pm September 27, 2013 Duncan Center, Delray Beach Friday 6:30 – 9:30 pm All Saint’s Episcopal Church, Ft. Lauderdale SOCIAL EVENT, BOOK SALE AND FILM featuring Dr. Richard Tarnas Please join us as we kick off our The film presentation will feature December 6 26th Season with an evening of a lecture by cultural historian, Friday 6:30 – 9:30 pm conversation, food and drinks - all philosopher, and psychologist Richard FREE - plus amazing bargains. Build Tarnas, Ph.D., renowned for his work THE PERSONAL EXPERIENCE OF THE SACRED your library with new and classic on Western thought and historical Jungian and other psychological events, on astrological developments, with Lionel Corbett, M.D., Jungian Analyst works, along with donated books at and on the connection between them. -
From Sacred Plants to Psychotherapy
From Sacred Plants to Psychotherapy: The History and Re-Emergence of Psychedelics in Medicine By Dr. Ben Sessa ‘The rejection of any source of evidence is always treason to that ultimate rationalism which urges forward science and philosophy alike’ - Alfred North Whitehead Introduction: What exactly is it that fascinates people about the psychedelic drugs? And how can we best define them? 1. Most psychiatrists will define psychedelics as those drugs that cause an acute confusional state. They bring about profound alterations in consciousness and may induce perceptual distortions as part of an organic psychosis. 2. Another definition for these substances may come from the cross-cultural dimension. In this context psychedelic drugs may be recognised as ceremonial religious tools, used by some non-Western cultures in order to communicate with the spiritual world. 3. For many lay people the psychedelic drugs are little more than illegal and dangerous drugs of abuse – addictive compounds, not to be distinguished from cocaine and heroin, which are only understood to be destructive - the cause of an individual, if not society’s, destruction. 4. But two final definitions for psychedelic drugs – and those that I would like the reader to have considered by the end of this article – is that the class of drugs defined as psychedelic, can be: a) Useful and safe medical treatments. Tools that as adjuncts to psychotherapy can be used to alleviate the symptoms and course of many mental illnesses, and 1 b) Vital research tools with which to better our understanding of the brain and the nature of consciousness. Classifying psychedelic drugs: 1,2 The drugs that are often described as the ‘classical’ psychedelics include LSD-25 (Lysergic Diethylamide), Mescaline (3,4,5- trimethoxyphenylathylamine), Psilocybin (4-hydroxy-N,N-dimethyltryptamine) and DMT (dimethyltryptamine). -
Psilocybin Mushrooms Fact Sheet
Psilocybin Mushrooms Fact Sheet January 2017 What are psilocybin, or “magic,” mushrooms? For the next two decades thousands of doses of psilocybin were administered in clinical experiments. Psilocybin is the main ingredient found in several types Psychiatrists, scientists and mental health of psychoactive mushrooms, making it perhaps the professionals considered psychedelics like psilocybin i best-known naturally-occurring psychedelic drug. to be promising treatments as an aid to therapy for a Although psilocybin is considered active at doses broad range of psychiatric diagnoses, including around 3-4 mg, a common dose used in clinical alcoholism, schizophrenia, autism spectrum disorders, ii,iii,iv research settings ranges from 14-30 mg. Its obsessive-compulsive disorder, and depression.xiii effects on the brain are attributed to its active Many more people were also introduced to psilocybin metabolite, psilocin. Psilocybin is most commonly mushrooms and other psychedelics as part of various found in wild or homegrown mushrooms and sold religious or spiritual practices, for mental and either fresh or dried. The most popular species of emotional exploration, or to enhance wellness and psilocybin mushrooms is Psilocybe cubensis, which is creativity.xiv usually taken orally either by eating dried caps and stems or steeped in hot water and drunk as a tea, with Despite this long history and ongoing research into its v a common dose around 1-2.5 grams. therapeutic and medical benefits,xv since 1970 psilocybin and psilocin have been listed in Schedule I of the Controlled Substances Act, the most heavily Scientists and mental health professionals criminalized category for drugs considered to have a consider psychedelics like psilocybin to be “high potential for abuse” and no currently accepted promising treatments as an aid to therapy for a medical use – though when it comes to psilocybin broad range of psychiatric diagnoses. -
Intrapsychic Perspectives on Personality
PSYCHODYNAMIC PERSPECTIVES ON PERSONALITY This educational CAPPE module is part i in section III: Theories of Human Functioning and Spirituality Written by Peter L. VanKatwyk, Ph.D. Introduction Psychodynamic theory goes back more than 100 years and has been a principal influence in the early history of clinical pastoral education (CPE). It is a way of thinking about personality dynamics in interpreting and understanding both the spiritual care-provider and care-receiver. This module will briefly summarize the basic theory and punctuate psychodynamic concepts that have been significant in the study of psychology of religion and theological reflection in the practice of spiritual care and counselling. Psychodynamic theories presently practiced include in historical sequence the following three schools that will be covered in this module: 1. Ego Psychology, following and extending the classic psychoanalytic theory of Freud, with major representatives in Anna Freud, Heinz Hartmann and Erik Erikson. 2. Object Relations Theory, derived from the work of Melanie Klein and members of the “British School,” including those who are prominent in religious studies and the practice of spiritual care: Ronald Fairbairn, Harry Guntrip, and D.W. Winnicott. 3. Self Psychology, modifying psychoanalytic theory with an interpersonal relations focus, originating in Heinz Kohut, systematized and applied for social work and counselling practice by Miriam Elson. In conjunction these psychodynamic theories offer three main perspectives on personality: 1. the human mind harbors conflict – with powerful unconscious forces that are continually thwarted in expressing themselves by a broad range of counteracting psychological processes and defense mechanisms. 2. each person carries an unconscious internalized world of personal relationships – with mental representations that reflect earlier experiences of self and others which often surface as patterns in current relationships and interpersonal problems. -
PSYCHEDELIC DRUGS (P.L) 1. Terminology “Hallucinogens
PSYCHEDELIC DRUGS (p.l) 1. Terminology “hallucinogens” – induce hallucinations, although sensory distortions are more common “psychotomimetics” – to minic psychotic states, although truly most drugs in this class do not do so “phantasticums”or “psychedelics” – alter sensory perception (Julien uses “psychedelics”) alterations in perception, cognition, and mood, in presence of otherwise clear ability to sense” may increase sensory awareness, increase clarity, decrease control over what is sensed/experienced “self-A” may feel a passive observer of what “self-B” is experiencing often accompanied by a sense of profound meaningfulness, of divine or cosmic importance (limbic system?) these drugs can be classified by what NT they mimic: anti-ACh, agonists for NE, 5HT, or glutamate (See p. 332, Table 12.l in Julien, 9th Ed.) 2. The Anti-ACh Psychedelics e.g. scopolamine (classified as an ACh blocker) high affinity, no efficacy plant product: Belladonna or “deadly nightshade” (Atropa belladonna) Datura stramonium (jimson weed, stinkweed) Mandragora officinarum (mandrake plant) pupillary dilation (2nd to atropine) PSYCHEDELIC DRUGS (p.2) 2. Anti-ACh Psychedelics (cont.) pharmacological effects: e.g. scopolamine (Donnatal) clinically used to tx motion sickness, relax smooth muscles (gastric cramping), mild sedation/anesthetic effect PNS effects --- dry mouth relaxation of smooth muscles decreased sweating increased body temperature blurred vision dry skin pupillary dilation tachycardia, increased BP CNS effects --- drowsiness, mild euphoria profound amnesia fatigue decreased attention, focus delirium, mental confusion decreased REM sleep no increase in sensory awareness as dose increases --- restlessness, excitement, hallucinations, euphoria, disorientation at toxic dose levels --- “psychotic delirium”, confusion, stupor, coma, respiratory depression so drug is really an intoxicant, amnestic, and deliriant 3. -
The Psychedelic Experience: the Importance of ‘Set’ and ‘Setting’
The Psychedelic Experience: The Importance of ‘Set’ and ‘Setting’ Matthew Nour & Jacob Krzanowski Matthew Nour, CT1 in Psychiatry, South London and Maudsley NHS Foundation Trust; Jacob Krzanowski, CT1 in Psychiatry, South London and Maudsley NHS Foundation Trust. Email: [email protected] *Both authors contributed equally to this work We welcome the renewed interest in the therapeutic potential of psychedelic compounds. In their recent editorial, Sessa and Johnson1 echo the fervent research climate surrounding psychedelics spanning the 1950s and 60s. They suggest that psychedelics may cause prolonged changes in subjects’ personalities and attitudes following mystical-spiritual experiences. This unique and exciting potential mechanism of action certainly warrants the current renaissance in psychedelic research, and has important implications for study design and subject selection. As we move towards re-exploring the clinical applications of psychedelics, however, we must appreciate that the phenomenology of the psychedelic experience is likely to depend not only on a drug’s pharmacodynamic properties, but also on the makeup of the subject (‘set’) and the environmental context (‘setting’) in which the drug is administered. Recent work suggests that the potential importance of ‘set’ in the psychedelic experience should not be overlooked. Hallucinogenic compounds act via the serotonergic 5-HT2A receptor to effect experience and behaviour. Genetic and neuroimaging evidence suggests that inter-subject differences in serotonergic neurotransmission -
Behavioral Epigenetics and the Developmental Origins of Child Mental Health Disorders
Journal of Developmental Origins of Health and Disease (2012), 3(6), 395–408. REVIEW & Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 doi:10.1017/S2040174412000426 Behavioral epigenetics and the developmental origins of child mental health disorders B. M. Lester1,2,3,4*, C. J. Marsit5, E. Conradt1,4, C. Bromer6 and J. F. Padbury3,4 1Brown Center for the Study of Children at Risk at Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA 2Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA 3Department of Pediatrics, Warren Alpen Medical School of Brown University, Providence, RI, USA 4Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA 5Departments of Pharmacology & Toxicology and Community & Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA 6Department of Neuroscience, Brown University, Providence, RI, USA Advances in understanding the molecular basis of behavior through epigenetic mechanisms could help explain the developmental origins of child mental health disorders. However, the application of epigenetic principles to the study of human behavior is a relatively new endeavor. In this paper we discuss the ‘Developmental Origins of Health and Disease’ including the role of fetal programming. We then review epigenetic principles related to fetal programming and the recent application of epigenetics to behavior. We focus on the neuroendocrine system and develop a simple heuristic stress-related model to illustrate how epigenetic changes in placental genes could predispose the infant to neurobehavioral profiles that interact with postnatal environmental factors potentially leading to mental health disorders. -
Archetypal Astrology and Transpersonal Psychology: the Research of Richard Tarnas and Stanislav Grof Renn Butler
Archetypal Astrology and Transpersonal Psychology: The Research of Richard Tarnas and Stanislav Grof Renn Butler In the mid-1960’s, a young Czechoslovakian psychiatrist working at the Psychiatric Research Institute in Prague made some epoch-making discoveries concerning the fundamental structures of the human psyche. Working with a wide range of individuals involved in supervised LSD psychotherapy, Stanislav Grof and his clients encountered experiences that gradually and then irrevocably challenged the orthodox Freudian model in which he and his colleagues were working. The content of the sessions suggested a far deeper understanding of the human psyche and the cosmos itself than had been previously imagined. After supervising 3,000 LSD sessions and studying the records of another 2,000, Grof eventually systematized a far- reaching model that accounted for the observations of his client’s sessions, integrated the diversity of competing psychological theories, and reached into areas of human spirituality described by the great spiritual traditions of the world. Stanislav Grof’s Expanded Cartography of the Human Psyche In 1976, Grof and his partner Christina developed a comparable non-drug technique for entering non-ordinary states of consciousness, which they called Holotropic Breathwork™ (from holos=“wholeness”; and trepein=“moving toward”). Throughout his long career of more than fifty-five years of research using powerful drug and non-drug catalysts, Grof discovered that individuals who enter holotropic states of consciousness have access to three broad layers of experience. The first layer is referred to as the biographical. This layer contains most of the material known from conventional psychotherapy. Individuals confront traumas and conflicts left over from physical and sexual abuse, a hostile family atmosphere, sibling rivalry, or severe toilet training. -
Classical Psychoanalysis Psikologi Kepribadian
Classical Psychoanalysis Psikologi Kepribadian Rizqy Amelia Zein 2017-09-14 1 / 67 [1] Image credit: Giphy 2 / 67 Classical Psychoanalysis [...also known as Ego Psychology, Psychodynamics] 3 / 67 First things rst: Instinct! 4 / 67 Instincts (1) Freud denes it as the motivating forces that drive behaviour and determine its direction. Instinct (or Trieb in German), is a form of energy, that is transformed into physical energy and serve its function to connect the physical and psychological needs. Freud argues that human always experience instinctual tension and unable to escape from it. So most of our activities are directed to reduce this tension. People could have different ways to reduce the tension (e.g. sexual drives can manifest in various sexual behaviours). It's also possible to substitute the objects (displacement) and this process is primarily important to determine one's behaviour. Freud coined the terms "life" and "death" instincts, which posit different process of primal motivations. 11 / 67 Instincts (2) The Life Instinct 1. Serve the purpose of survival of the individual and the species by seeking to satisfy the needs for food, water, air, and sex. 2. The life instincts are oriented toward growth and development. The psychic energy manifested by the life instincts is the libido. 3. The libido can be attached to or invested in objects, a concept Freud called cathexis. 4. So if you like Ryan Gosling so much, for example, then your libido is cathected to him. 12 / 67 Instincts (2) The Death Instinct 1. In opposition to the life instincts, Freud postulated the destructive or death instincts. -
Ecstasy and Club Drugs
Ecstasy and Club Drugs The term “club drug” refers to drugs being used by youth and young adults at all-night dance parties such as “raves” or “trances,” dance clubs and bars. MDMA (Ecstasy), GHB, Rohypnol, Ketamine, Methamphetamine, and LSD are among the drugs referred to as “club drugs.” “Raves” are a form of dance and recreation that is held in a clandestine location with fast-paced, high-volume music, a variety of high-tech entertainment and usually the use of “club drugs.” Ecstasy Ecstasy or MDMA (methylenedioxymethamphetamine) is a stimulant that combines the properties of methamphetamine or “speed” with mind-altering or hallucinogenic properties. It is considered to be the most commonly used club (or “designer” drug). Ecstasy is an illegal drug (it was declared illegal by the federal government in 1985) 90% of which is manufactured in the Netherlands and Belgium. In its most common form, Ecstasy is a small tablet that is impressed with any one of a number of logos intended to attract young people. It can also be in capsule or powder form and can be injected. Among the street names for Ecstasy are Adam, X-TC, Clarity, Essence, Stacy, Lover’s Speed, Eve, etc. The Ecstasy high can last from 6 to 24 hours, with the average “trip” lasting only about 3-4 hours. Users of Ecstasy report that it causes mood changed and loosens their inhibitions; they become more outgoing, empathetic and affectionate. For this reason, Ecstasy has been called the “hug drug.” It also suppresses the need to eat, drink or sleep, enabling users to endure parties that can last for two or three days. -
Behavioral Neuroscience and Psychopharmacology
Behavioral Neuroscience and Psychopharmacology The Behavioral Neuroscience and Psychopharmacology area of concentration is designed to train students broadly in the general theoretical principles and technical approaches used to investigate the neurobehavioral mechanisms of alcohol and drug abuse. Psychopharmacological approaches to understanding basic principles of learning are also emphasized. Students receive a concentrated lab experience using either animal models (quail, mice or rats) or human subjects. Faculty in the program use different levels of analysis including cell culture models, neurochemical assays, developmental toxicology, classical conditioning of drug effects, operant conditioning, human behavioral pharmacology, and cognitive approaches to behavior. Students are expected to receive in depth training in at least one level of analysis although training that integrates more than one level of analysis is strongly encouraged. PROGRAM REQUIREMENTS COURSE REQUIREMENTS (1) Statistics sequence: PSY 610 - Experimental design PSY 611 - Correlational design (2) PSY 780 - Directed BNP studies PSY 780A - first year students only PSY 780B - first year and beyond (3) Any three proseminars selected from the following areas: Learning Cognitive processes Developmental Psychology Sensation & Perception Physiological Psychology (4) Four electives (a minimum of one of these must be outside of the Psychology Department) (see listing of some possible options on page **). (5) Additional course work as recommended by the advisory committee RESEARCH REQUIREMENTS It is expected that all students in the BNP area will be involved in research thorough out their course of study towards the Ph.D. The area has two formalized requirements that are designed to train the student in conducting research: (1) Master's thesis (2) Dissertation ALLIED AREA REQUIREMENT Each student is expected to develop an allied area to gain expertise in some area outside of the student's main research specialty.