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PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects
International Journal of Molecular Sciences Review PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects Rosalin Mishra , Hima Patel, Samar Alanazi , Mary Kate Kilroy and Joan T. Garrett * Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA; [email protected] (R.M.); [email protected] (H.P.); [email protected] (S.A.); [email protected] (M.K.K.) * Correspondence: [email protected]; Tel.: +1-513-558-0741; Fax: +1-513-558-4372 Abstract: The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian, colorectal, prostate, glioblastoma and endometrial cancers. PI3K signaling plays an important role in cancer cell survival, angiogenesis and metastasis, making it a promising therapeutic target. There are several ongoing and completed clinical trials involving PI3K inhibitors (pan, isoform-specific and dual PI3K/mTOR) with the goal to find efficient PI3K inhibitors that could overcome resistance to current therapies. This review focuses on the current landscape of various PI3K inhibitors either as monotherapy or in combination therapies and the treatment outcomes involved in various phases of clinical trials in different cancer types. There is a discussion of the drug-related toxicities, challenges associated with these PI3K inhibitors and the adverse events leading to treatment failure. In addition, novel PI3K drugs that have potential to be translated in the clinic are highlighted. Keywords: cancer; PIK3CA; resistance; PI3K inhibitors Citation: Mishra, R.; Patel, H.; Alanazi, S.; Kilroy, M.K.; Garrett, J.T. -
Ahead of the Rest
2016 2017 Ahead of the Rest Welcome to our proud “Family of Products” Merging Finger Lakes, Castle, Econo, and Echo into one catalog displays www.CastleOctaServices.com America’s broadest line of professional products. Decades of research and development have helped us create a deep, multi-dimensional line. Five reasons why the Castle Group is your best value: PROFITS 1 Since 1967 our trademarked packaging and patented formulas have given exciting new profit opportunities. SUPPORT 2 Service menus, training seminars, POP displays, radio and TV tags, and apparel. FACTORY DIRECT 3 Strategically placed satellite warehouses provide service with no freight and no minimum. Battery HI-TECH Service 4 Product Technical Info is constantly updated. We help you satisfy your “User Right to Know” responsibilities! SAFETY 5 We help you comply with government regulations. The Castle Racing Team started in the early 1970’s with the inception of the Castle Dragon Fire Dragster. Over the years Castle cars and crews have been spotted at drag strips, dirt tracks, and asphalt circuits: 1980’s: J.D. McDuffie uses Castle in his shop and Castle on his #70 Pontiac in the Winston Cup Series. 2002 – 05: Castle unveils its “Racing for Clean Air” Campaign, with Andy Santerre as Racing Team Captain. Andy was NASCAR Busch North Series (BNS) Rookie-of-the-Year in 1993 and NASCAR Busch Series Rookie-of-the-Year in 1998. Santerre would go on to win four straight BNS Points Championships (2002-2005). 2006: Andy retires from racing to concentrate on building race cars and tutoring young drivers as Andy Santerre Motorsports (ASM). -
Resurrect Your Old PC
Resurrect your old PCs Resurrect your old PC Nostalgic for your old beige boxes? Don’t let them gather dust! Proprietary OSes force users to upgrade hardware much sooner than necessary: Neil Bothwick highlights some great ways to make your pensioned-off PCs earn their keep. ardware performance is constantly improving, and it is only natural to want the best, so we upgrade our H system from time to time and leave the old ones behind, considering them obsolete. But you don’t usually need the latest and greatest, it was only a few years ago that people were running perfectly usable systems on 500MHz CPUs and drooling over the prospect that a 1GHz CPU might actually be available quite soon. I can imagine someone writing a similar article, ten years from now, about what to do with that slow, old 4GHz eight-core system that is now gathering dust. That’s what we aim to do here, show you how you can put that old hardware to good use instead of consigning it to the scrapheap. So what are we talking about when we say older computers? The sort of spec that was popular around the turn of the century. OK, while that may be true, it does make it seem like we are talking about really old hardware. A typical entry-level machine from six or seven years ago would have had something like an 800MHz processor, Pentium 3 or similar, 128MB of RAM and a 20- 30GB hard disk. The test rig used for testing most of the software we will discuss is actually slightly lower spec, it has a 700MHz Celeron processor, because that’s what I found in the pile of computer gear I never throw away in my loft, right next to my faithful old – but non-functioning – Amiga 4000. -
Medcruise Newsletter Issue 52 Nov 2016.Qxp 22/11/2016 14:48 Page 1
MedCruise Newsletter Issue 52 Nov 2016.qxp 22/11/2016 14:48 Page 1 MedCruise News MedCruise members discuss November 2016 “Guidelines for Cruise Terminals” Issue 52 MedCruise News pg. 1-7 Barcelona), Chairman of the Port facilities & PIANC International Destinations pg. 8-22 Working Group that developed this major project over the course of the last Meet the MedCruise four years, revealed members pg. 23 to the MedCruise membership the just completed study List of MedCruise that embodies a Members pg. 24 flexible design approach so that terminals can be adapted to the various current and and ground transportation area. future needs of In view of the importance to the cruise n Friday, September 23rd, MedCruise cruise companies. industry of port security and operational and members had an excellent opportunity Following the presentation, MedCruise financial aspects, special emphasis has been to discuss best strategies to invest in members had the opportunity to engage in an laid on these two topics. O extended Q&A session, while each member This report has been drafted by an cruise terminals, during a special session held in Santa Cruz de Tenerife on the occasion of also received a copy of the study that provides international working group (WG 152) set up Seatrade Cruise Med 2016. technical guidelines for assisting the by PIANC in 2012. The main objective of the During the session, MedCruise members also development of cruise port facilities. Based on work was to provide a guideline for the discussed in detail the results of the most the newest trends in cruise ships and the functional design of cruise terminals, by recent PIANC study on cruise terminals industry in general, the document covers all reviewing the needs of modern cruise ships investment, planning & design. -
Chivalry in Western Literature Richard N
Rollins College Rollins Scholarship Online Master of Liberal Studies Theses 2012 The nbU ought Grace of Life: Chivalry in Western Literature Richard N. Boggs Rollins College, [email protected] Follow this and additional works at: http://scholarship.rollins.edu/mls Part of the English Language and Literature Commons, European History Commons, Medieval History Commons, and the Medieval Studies Commons Recommended Citation Boggs, Richard N., "The nbouU ght Grace of Life: Chivalry in Western Literature" (2012). Master of Liberal Studies Theses. 21. http://scholarship.rollins.edu/mls/21 This Open Access is brought to you for free and open access by Rollins Scholarship Online. It has been accepted for inclusion in Master of Liberal Studies Theses by an authorized administrator of Rollins Scholarship Online. For more information, please contact [email protected]. The Unbought Grace of Life: Chivalry in Western Literature A Project Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Liberal Studies by Richard N. Boggs May, 2012 Mentor: Dr. Thomas Cook Reader: Dr. Gail Sinclair Rollins College Hamilton Holt School Master of Liberal Studies Program Winter Park, Florida The Unbought Grace of Life: Chivalry in Western Literature By Richard N. Boggs May, 2012 Project Approved: ________________________________________ Mentor ________________________________________ Reader ________________________________________ Director, Master of Liberal Studies Program ________________________________________ Dean, Hamilton Holt School Rollins College Dedicated to my wife Elizabeth for her love, her patience and her unceasing support. CONTENTS I. Introduction 1 II. Greek Pre-Chivalry 5 III. Roman Pre-Chivalry 11 IV. The Rise of Christian Chivalry 18 V. The Age of Chivalry 26 VI. -
The Formation and Early History of the Knights of Ak-Sar-Ben As Shown by Omaha Newspapers
University of Nebraska at Omaha DigitalCommons@UNO Student Work 11-1-1962 The formation and early history of the Knights of Ak-Sar-Ben as shown by Omaha newspapers Arvid E. Nelson University of Nebraska at Omaha Follow this and additional works at: https://digitalcommons.unomaha.edu/studentwork Recommended Citation Nelson, Arvid E., "The formation and early history of the Knights of Ak-Sar-Ben as shown by Omaha newspapers" (1962). Student Work. 556. https://digitalcommons.unomaha.edu/studentwork/556 This Thesis is brought to you for free and open access by DigitalCommons@UNO. It has been accepted for inclusion in Student Work by an authorized administrator of DigitalCommons@UNO. For more information, please contact [email protected]. r m formation t m im u t m s toot of THE KNIQHTS OF A&~SAR-BBK AS S H O M nr OSAKA NEWSPAPERS A Thaoia Praaentad to the Faculty or tha Dapartmant of History Runic1pal University of Omaha In Partial Fulfilimant of the Requirements for the Degree Master of Art# by Arvld & liaison Ur. November 1^62 UMI Number: EP73194 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI EP73194 Published by ProQuest LLC (2015). Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. -
(12) Patent Application Publication (10) Pub. No.: US 2014/0290802 A1 Morita Et Al
US 201402908O2A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0290802 A1 Morita et al. (43) Pub. Date: Oct. 2, 2014 (54) SURFACE TREATMENT METHOD AND (30) Foreign Application Priority Data COATING METHOD FOR STEEL MATERIAL, AND METHOD FOR PRODUCING MACHINE Oct. 25, 2011 (JP) ................................. 2011-234331 COMPONENT Publication Classification (51) Int. Cl. (75) Inventors: Haruji Morita, Hanno-shi (JP); Tsuneo C23C 8/42 (2006.01) Tate, Setagaya-ku (JP); Akira C23C 8/80 (2006.01) Shiozawa, Okaya-shi (JP) (52) U.S. Cl. CPC. C23C 8/42 (2013.01); C23C 8/80 (2013.01) (73) Assignees: KOMATSU LTD., Tokyo (JP); USPC ........................................... 148/241; 148/253 NIPPON KAZAI CO.,LTD., Okaya-shi, Nagano (JP); COTEC (57) ABSTRACT CORPORATION, Tokyo (JP) This Surface treatment method comprises a rustproofing step, a rinsing step, and a cleaning step. In the rustproofing step, a (21) Appl. No.: 14/350,724 rustproofing liquid containing orthophosphoric acid and an organic acid is used to perform a rustproofing treatment on the (22) PCT Filed: Sep. 12, 2012 Surface of a steel material. In the rinsing step, a treatment 9 liquid containing an oxoacid salt of a transition metal is used to perform a rinsing treatment on the Surface of the Steel (86). PCT No.: PCT/UP2012/073363 material. In the cleaning step, the Surface of the steel material S371 (c)(1), that has undergone the rinsing step is subjected to a cleaning (2), (4) Date: Apr. 9, 2014 treatment. (a) Shape of film formed by this surface treatment method (SEM, x10,000) Patent Application Publication Oct. -
A Report to the President U.S
A Report to the President U.S. Department of the Interior 2017-2021 REPORT TO THE PRESIDENT 2017-2021 U.S. Department of the Interior JANUARY 15, 2021 Report to the President Report to the President U.S. DEPARTMENT OF THE INTERIOR LETTER TO THE PRESIDENT The Department of the Interior (Department) has focused on improving the ways we serve the American public, while moving forward with your policy priorities. In doing so, the Department has made incredible progress furthering conservation stewardship, expanding opportunities to hunt and fish on public lands, improving core administrative functions, creating a common-sense regulatory regime, and enhancing our Nation’s energy independence. On behalf of the more than 65,000 Secretary David L. Bernhardt dedicated employees who work diligently across our Nation to accomplish important missions in service to the American people, I am pleased to present the Department’s Summary of Actions Report for 2017- 2021. This report highlights the Department’s major and historic achievements toward fulfilling your vision on behalf of all Americans. David L. Bernhardt Secretary of the Interior Page 1 Report to the President PURPOSE AND INTRODUCTION Secretary Bernhardt and First Lady Melania Trump at Grand Teton National Park From the beginning days of the Trump-Pence Administration, President Donald J. Trump gave clear direction to the Department of the Interior (Department, DOI, or Interior). He set priorities and ambitious goals, challenging Federal agencies through Governmentwide Executive orders, Presidential memoranda, and other actions to deliver better results for the American people. Interior has worked relentlessly to implement the President’s agenda for the betterment of our society and economy. -
Costume Crafts an Exploration Through Production Experience Michelle L
Louisiana State University LSU Digital Commons LSU Master's Theses Graduate School 2010 Costume crafts an exploration through production experience Michelle L. Hathaway Louisiana State University and Agricultural and Mechanical College, [email protected] Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_theses Part of the Theatre and Performance Studies Commons Recommended Citation Hathaway, Michelle L., "Costume crafts na exploration through production experience" (2010). LSU Master's Theses. 2152. https://digitalcommons.lsu.edu/gradschool_theses/2152 This Thesis is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Master's Theses by an authorized graduate school editor of LSU Digital Commons. For more information, please contact [email protected]. COSTUME CRAFTS AN EXPLORATION THROUGH PRODUCTION EXPERIENCE A Thesis Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Master of Fine Arts in The Department of Theatre by Michelle L. Hathaway B.A., University of Colorado at Denver, 1993 May 2010 Acknowledgments First, I would like to thank my family for their constant unfailing support. In particular Brinna and Audrey, girls you inspire me to greatness everyday. Great thanks to my sister Audrey Hathaway-Czapp for her personal sacrifice in both time and energy to not only help me get through the MFA program but also for her fabulous photographic skills, which are included in this thesis. I offer a huge thank you to my Mom for her support and love. -
2013 Northern New Brunswick Cruise Strategy
LET’S CRUISE! A Winning Cruise Strategy for Northern New Brunswick Submitted to: Province of New Brunswick Tourism, Heritage and Culture by Melanie Colpitts AQUILA PO Box 6895, 10 St James Street Saint John, New Brunswick E2L 4S3 Email: [email protected] T 506/633-1224 F 506/658-0969 June 2013 Table of Contents Executive Summary ..................................................................................................................................... 4 1. Introduction .......................................................................................................................................... 7 1.1. Background Information .............................................................................................................. 7 1.2. Objectives & Key Considerations ................................................................................................. 7 1.3. Methodology ............................................................................................................................... 8 1.4. Port Selection Process ............................................................................................................... 10 1.5. Key Terms .................................................................................................................................. 11 2. Key Findings for Success in the Cruise Market ................................................................................... 12 2.1. Critical Keys to Success in the Cruise Market ........................................................................... -
Studying Craft: Trends in Craft Education and Training Participation in Contemporary Craft Education and Training
Studying craft: trends in craft education and training Participation in contemporary craft education and training Cover Photography Credits: Clockwise from the top: Glassmaker Michael Ruh in his studio, London, December 2013 © Sophie Mutevelian Head of Art Andrew Pearson teaches pupils at Christ the King Catholic Maths and Computing College, Preston Cluster, Firing Up, Year One. © University of Central Lancashire. Silversmith Ndidi Ekubia in her studio at Cockpit Arts, London, December 2013 © Sophie Mutevelian ii ii Participation in contemporary craft education and training Contents 1. GLOSSARY 3 2. FOREWORD 4 3. EXECUTIVE SUMMARY 5 3.1 INTRODUCTION 5 3.2 THE OFFER AND TAKE-UP 5 3.3 GENDER 10 3.4 KEY ISSUES 10 3.5 NEXT STEPS 11 4. INTRODUCTION 12 4.1 SCOPE 13 4.2 DEFINITIONS 13 4.3 APPROACH 14 5. POLICY TIMELINE 16 6. CRAFT EDUCATION AND TRAINING: PROVISION AND PARTICIPATION 17 6.1 14–16 YEARS: KEY STAGE 4 17 6.2 16–18 YEARS: KEY STAGE 5 / FE 22 6.3 ADULTS: GENERAL FE 30 6.4 ADULTS: EMPLOYER-RELATED FE 35 6.5 APPRENTICESHIPS 37 6.6 HIGHER EDUCATION 39 6.7 COMMUNITY LEARNING 52 7. CONCLUDING REMARKS 56 8. APPENDIX: METHODOLOGY 57 9. NOTES 61 1 Participation in contemporary craft education and training The Crafts Council is the national development agency for contemporary craft. Our goal is to make the UK the best place to make, see, collect and learn about contemporary craft. www.craftscouncil.org.uk TBR is an economic development and research consultancy with niche skills in understanding the dynamics of local, regional and national economies, sectors, clusters and markets. -
Suckless.Org Software That Sucks Less
suckless.org software that sucks less markus schnalke <[email protected]> a website a couple of projects a community a philosophy . not a summary, but we’ll have one at the end what is suckless.org? something that Anselm R. Garbe started a couple of projects a community a philosophy . not a summary, but we’ll have one at the end what is suckless.org? something that Anselm R. Garbe started a website a community a philosophy . not a summary, but we’ll have one at the end what is suckless.org? something that Anselm R. Garbe started a website a couple of projects a philosophy . not a summary, but we’ll have one at the end what is suckless.org? something that Anselm R. Garbe started a website a couple of projects a community . not a summary, but we’ll have one at the end what is suckless.org? something that Anselm R. Garbe started a website a couple of projects a community a philosophy what is suckless.org? something that Anselm R. Garbe started a website a couple of projects a community a philosophy . not a summary, but we’ll have one at the end the website website www.suckless.org main page (links to everything else) lists.suckless.org the mailinglists archives code.suckless.org the source code repositories (Mercurial) the wiki the wiki software I hgiki (genosite) I self made by arg I shell script with 100 SLOC I uses markdown markup content I kept in Mercurial repo I write access to preview wiki (port 8000) I hg clone http://www.suckless.org:8000/hg/wiki I vi <some-file> I hg commit && hg push the couple of projects projects window managers I wmii I dwm IRC clients I sic I ii various tools I dmenu, slock, sselp, lsx, .