GRAP (NM 006613) Human Recombinant Protein Product Data

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GRAP (NM 006613) Human Recombinant Protein Product Data

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TP308908 GRAP (NM_006613) Human Recombinant Protein Product data: Product Type: Recombinant Proteins Description: Recombinant protein of human GRB2-related adaptor protein (GRAP) Species: Human Expression Host: HEK293T Tag: C-Myc/DDK Predicted MW: 25.2 kDa Concentration: >50 ug/mL as determined by microplate BCA method Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. Storage: Store at -80°C. Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. RefSeq: NP_006604 Locus ID: 10750 UniProt ID: Q13588 RefSeq Size: 2089 Cytogenetics: 17p11.2 RefSeq ORF: 651 Synonyms: DFNB114 This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 GRAP (NM_006613) Human Recombinant Protein – TP308908 Summary: This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012] Product images: Coomassie blue staining of purified GRAP protein (Cat# TP308908). The protein was produced from HEK293T cells transfected with GRAP cDNA clone (Cat# [RC208908]) using MegaTran 2.0 (Cat# [TT210002]). This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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Tyrosine Kinase Oncogenes in Normal Hematopoiesis and Hematological Disease
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