GRAP Rabbit Pab

Total Page：16

File Type：pdf, Size：1020Kb

Leader in Biomolecular Solutions for Life Science GRAP Rabbit pAb Catalog No.: A15391 Basic Information Background Catalog No. This gene encodes a member of the GRB2/Sem5/Drk family and functions as a A15391 cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor Observed MW and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL 36kDa oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In Calculated MW general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras 25kDa signaling pathway. Category Primary antibody Applications WB Cross-Reactivity Human Recommended Dilutions Immunogen Information WB 1:200 - 1:2000 Gene ID Swiss Prot 10750 Q13588 Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 128-217 of human GRAP (NP_006604.1). Synonyms GRAP Contact Product Information 400-999-6126 Source Isotype Purification Rabbit IgG Affinity purification [email protected] www.abclonal.com.cn Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using GRAP antibody (A15391) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

Copy Link

Recommended publications

Tyrosine Kinase Oncogenes in Normal Hematopoiesis and Hematological Disease
Oncogene (2002) 21, 3314 ± 3333 ã 2002 Nature Publishing Group All rights reserved 0950 ± 9232/02 $25.00 www.nature.com/onc Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease Blanca Scheijen1,2 and James D Grin*,1,2 1Department of Adult Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, MA 02115, USA; 2Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA Tyrosine kinase oncogenes are formed as a result of Adaptors do not contain intrinsic catalytic activity but mutations that induce constitutive kinase activity. Many consist of independent functioning interaction modules of these tyrosine kinase oncogenes that are derived from like SH2-domain (mediates binding to phosphotyrosine genes, such as c-Abl, c-Fes, Flt3, c-Fms, c-Kit and residues), SH3-domain (interacts with polyproline-rich PDGFRb, that are normally involved in the regulation of PXXP stretch) or pleckstrin homology (PH) domain hematopoiesis or hematopoietic cell function. Despite (binds to inositol lipids). dierences in structure, normal function, and subcellular The ®rst tyrosine kinase oncogene associated with location, many of the tyrosine kinase oncogenes signal human hematologic disease, Bcr ± Abl, was identi®ed through the same pathways, and typically enhance almost twenty years ago, and there is now evidence for proliferation and prolong viability. They represent involvement of multiple tyrosine kinase oncogenes in excellent potential drug targets, and it is likely that acute and chronic leukemias, lymphomas, and myelo- additional mutations will be identi®ed in other kinases, mas. In each case, the tyrosine kinase activity of the their immediate downstream targets, or in proteins oncogene is constitutively activated by mutations that regulating their function.
[Show full text]
Anti-GRAP Antibody (ARG63124)
Product datasheet [email protected] ARG63124 Package: 100 μg anti-GRAP antibody Store at: -20°C Summary Product Description Goat Polyclonal antibody recognizes GRAP Tested Reactivity Hu Predict Reactivity Ms, Rat, Cow Tested Application WB Host Goat Clonality Polyclonal Isotype IgG Target Name GRAP Antigen Species Human Immunogen C-GFFPRSYVQPVHL Conjugation Un-conjugated Alternate Names GRB2-related adapter protein Application Instructions Application table Application Dilution WB 0.3 - 1 µg/ml Application Note WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. Calculated Mw 25 kDa Properties Form Liquid Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA Preservative 0.02% Sodium azide Stabilizer 0.5% BSA Concentration 0.5 mg/ml Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. www.arigobio.com 1/2 Note For laboratory research only, not for drug, diagnostic or other use. Bioinformation Database links GeneID: 10750 Human Swiss-port # Q13588 Human Background This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains.
[Show full text]
Biological Databases What Is a Database ?
BIOLOGICAL DATABASES WHAT IS A DATABASE ? A structured collection of data held in computer storage; esp. one that incorporates software to make it accessible in a variety of ways; any large collection of information. A collection of data structured searchable (index) -> table of contents updated periodically (release) -> new edition cross-referenced (hyperlinks ) -> links with other db Includes also associated tools (software) necessary for access, updating, information insertion, information deletion…. A database consists of basic units called records or entries. Each record consists of fields, which hold pre-defined data related to the record. For example, a protein database would have protein sequences as records and protein properties as fields (e.g., name of protein, length, amino-acid sequence, …) 2 DATABASES ON THE INTERNET Biological databases often have web interfaces, which allow users to send queries to the databases. Some databases can be accessed by different web servers, each offering a different interface. request query web page result User Web server Database server 3 WHY BIOLOGICAL DATABASES ? Exponential growth in biological data. Data (genomic sequences, 3D structures, 2D gel analysis, MS analysis, Microarrays….) are no longer published in a conventional manner, but directly submitted to databases. Essential tools for biological research. The only way to publish massive amounts of data without using all the paper in the world. 4 NUCLEOTIDES 5 COMPLETE GENOMES Until 2018: Eukaryotes 5262 Prokaryotes 131446 Viruses 14027 6 SOME STATISTICS More than 1000 different ‘biological’ databases Variable size: <100Kb to >20Gb DNA: > 20 Gb Protein: 1 Gb 3D structure: 5 Gb Other: smaller Update frequency: daily to annually to seldom to forget about it .
[Show full text]
Chromosomal Instability and Copy Number Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma Thomas G
Human Cancer Biology Chromosomal Instability and Copy Number Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma Thomas G. Paulson,1,2 Carlo C. Maley,4,5 Xiaohong Li,2 Hongzhe Li,6 Carissa A. Sanchez,1,2 Dennis L. Chao,3 Robert D. Odze,7 Thomas L. Vaughan,2,8 Patricia L. Blount,1,2,10 and Brian J. Reid1,2,9,10 Abstract Purpose: Chromosomal instability, as assessed by many techniques, including DNA content aneuploidy, loss of heterozygosity, and comparative genomic hybridization, has consistently been reported to be common in cancer and rare in normal tissues. Recently, a panel of chromosome instability biomarkers, including loss of heterozygos- ity and DNA content, has been reported to identify patients at high and low risk of pro- gression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA), but required multiple platforms for implementation. Although chromosomal instability in- volving amplifications and deletions of chromosome regions have been observed in nearly all cancers, copy number alterations (CNA) in premalignant tissues have not been well characterized or evaluated in cohort studies as biomarkers of cancer risk. Experimental Design: We examined CNAs in 98 patients having either BE or EA using Bacterial Artificial Chromosome (BAC) array comparative genomic hybridization to char- acterize CNAs at different stages of progression ranging from early BE to advanced EA. Results: CNAs were rare in early stages (less than high-grade dysplasia) but were pro- gressively more frequent and larger in later stages (high-grade dysplasia and EA), in- cluding high-level amplifications. The number of CNAs correlated highly with DNA content aneuploidy.
[Show full text]
NLRP3 and ASC Differentially Affect the Lung Transcriptome During Pneumococcal Pneumonia
UvA-DARE (Digital Academic Repository) Cell-specific pattern recognition receptor signaling in antibacterial defense van Lieshout, M.H.P. Publication date 2015 Document Version Final published version Link to publication Citation for published version (APA): van Lieshout, M. H. P. (2015). Cell-specific pattern recognition receptor signaling in antibacterial defense. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:30 Sep 2021 Chapter 7 NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia American Journal of Respiratory Cell and Molecular Biology 2014 Apr;50(4):699-712 DOI: 10.1165/rcmb.2013-0015OC Miriam H.P. van Lieshout 1,2 Brendon P. Scicluna 1,2 Sandrine Florquin 3 Tom van der Poll 1,2,4 Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands: 1Center of Infection and Immunity Amsterdam 2Center of Experimental and Molecular Medicine 3Department of Pathology 4Division of Infectious Diseases Chapter 7 Abstract Streptococcus (S.) pneumoniae is the most frequently isolated causative pathogen of community-acquired pneumonia, a leading cause of mortality worldwide.
[Show full text]
GRAP (NM 006613) Human Tagged ORF Clone Product Data
OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for RG208908 GRAP (NM_006613) Human Tagged ORF Clone Product data: Product Type: Expression Plasmids Product Name: GRAP (NM_006613) Human Tagged ORF Clone Tag: TurboGFP Symbol: GRAP Synonyms: DFNB114 Vector: pCMV6-AC-GFP (PS100010) E. coli Selection: Ampicillin (100 ug/mL) Cell Selection: Neomycin ORF Nucleotide >RG208908 representing NM_006613 Sequence: Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGTCCGTGGCCCTGTACAGCTTTCAGGCTACAGAGAGCGACGAGCTGGCCTTCAACAAGGGAGACA CACTCAAGATCCTGAACATGGAGGATGACCAGAACTGGTACAAGGCCGAGCTCCGGGGTGTCGAGGGATT TATTCCCAAGAACTACATCCGCGTCAAGCCCCATCCGTGGTACTCGGGCAGGATTTCCCGGCAGCTGGCC GAAGAGATTCTGATGAAGCGGAACCATCTGGGAGCCTTCCTGATCCGGGAGAGTGAGAGCTCCCCAGGGG AGTTCTCTGTGTCTGTGAACTATGGAGACCAGGTGCAGCACTTCAAGGTGCTGCGTGAGGCCTCGGGGAA GTACTTCCTGTGGGAGGAGAAGTTCAACTCCCTCAACGAGCTGGTCGACTTCTACCGCACCACCACCATC GCCAAGAAGCGGCAGATCTTCCTGCGCGACGAGGAGCCCTTGCTCAAGTCACCTGGGGCCTGCTTTGCCC AGGCCCAGTTTGACTTCTCAGCCCAGGACCCCTCGCAGCTCAGCTTCCGCCGTGGCGACATCATTGAGGT CCTGGAGCGCCCAGACCCCCACTGGTGGCGGGGCCGGTCCTGCGGGCGCGTTGGCTTCTTCCCACGGAGT TACGTGCAGCCCGTGCACCTG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA Protein Sequence: >RG208908 representing NM_006613 Red=Cloning site Green=Tags(s) MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPWYSGRISRQLA EEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTI
[Show full text]
Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers Int Cells
REVIEW ARTICLE published: 04 September 2013 doi: 10.3389/fimmu.2013.00239 Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers inT cells Jesse E. Jun1, Ignacio Rubio2 and Jeroen P.Roose 1* 1 Department of Anatomy, University of California San Francisco, San Francisco, CA, USA 2 Institute for Molecular Cell Biology, Center for Sepsis Control and Care (CSCC), University Hospital, Friedrich-Schiller-University, Jena, Germany Edited by: The Ras-MAPK signaling pathway is highly conserved throughout evolution and is acti- Karsten Sauer, The Scripps Research vated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange Institute, USA factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating receptor- Reviewed by: Kjetil Taskén, University of Oslo, ligand induced Ras activity. In T cells, three families of functionally important RasGEFs are Norway expressed: RasGRF,RasGRP,and Son of Sevenless (SOS)-family GEFs. Early on it was rec- Balbino Alarcon, Consejo Superior de ognized that Ras activation is critical for T cell development and that the RasGEFs play an Investigaciones Cientificas, Spain important role herein. More recent work has revealed that nuances in Ras activation appear *Correspondence: to significantly impactT cell development and selection.These nuances include distinct bio- Jeroen P.Roose, Department of Anatomy, University of California San chemical patterns of analog versus digital Ras activation, differences in cellular localization Francisco, 513 Parnassus Avenue, of Ras activation, and intricate interplays between the RasGEFs during distinctT cell devel- Room HSW-1326, San Francisco, CA opmental stages as revealed by various new mouse models.
[Show full text]
And Y-Linked Ampliconic Genes in Human Populations
HIGHLIGHTED ARTICLE | INVESTIGATION Dynamic Copy Number Evolution of X- and Y-Linked Ampliconic Genes in Human Populations Elise A. Lucotte,1 Laurits Skov, Jacob Malte Jensen, Moisès Coll Macià, Kasper Munch, and Mikkel H. Schierup Bioinformatic Research Center, Aarhus University, 8000, Denmark ORCID ID: 0000-0001-8442-2654 (E.A.L.) ABSTRACT Ampliconic genes are multicopy, with the majority found on sex chromosomes and enriched for testis-expressed genes. While ampliconic genes have been associated with the emergence of hybrid incompatibilities, we know little about their copy number distribution and their turnover in human populations. Here, we explore the evolution of human X- and Y-linked ampliconic genes by investigating copy number variation (CNV) and coding variation between populations using the Simons Genome Diversity Project. We develop a method to assess CNVs using the read depth on modified X and Y chromosome targets containing only one repetition of each ampliconic gene. Our results reveal extensive standing variation in copy number both within and between human populations for several ampliconic genes. For the Y chromosome, we can infer multiple independent amplifications and losses of these gene copies even within closely related Y haplogroups, that diversified , 50,000 years ago. Moreover, X- and Y-linked ampliconic genes seem to have a faster amplification dynamic than autosomal multicopy genes. Looking at expression data from another study, we also find that X- and Y-linked ampliconic genes with extensive CNV are significantly more expressed than genes with no CNV during meiotic sex chromosome inactivation (for both X and Y) and postmeiotic sex chromosome repression (for the Y chromosome only).
[Show full text]
Gads Is a Novel SH2 and SH3 Domain-Containing Adaptor Protein That Binds to Tyrosine-Phosphorylated Shc
Oncogene (1998) 17, 3073 ± 3082 ã 1998 Stockton Press All rights reserved 0950 ± 9232/98 $12.00 http://www.stockton-press.co.uk/onc Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc Stanley K Liu and C Jane McGlade Department of Medical Biophysics, Ontario Cancer Institute, AMGEN Institute, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario, Canada, M5G 2C1 Shc proteins are important substrates of receptor and human tumor cells with known tyrosine kinase gene cytoplasmic tyrosine kinases that couple activated alterations (Pelicci et al., 1995). Following tyrosine- receptors to downstream signaling enzymes. Phosphor- phosphorylation, Shc associates with the SH2 and ylation of Shc tyrosine residues 239 and 317 leads to SH3 domain-containing adaptor protein, Grb2 (Low- recruitment of the Grb2-Sos complex, thus linking Shc enstein et al., 1992; Rozakis-Adcock et al., 1992). This phosphorylation to Ras activation. We have used interaction is mediated by the phosphorylated tyrosine phosphorylated peptides corresponding to the regions residues 239 and 317 of Shc which are both found spanning tyrosine 239/240 and 317 of Shc in an within a sequence conforming to a high anity expression library screen to identify additional down- binding site for the Grb2 SH2 domain (Salcini et stream targets of Shc. Here we report the identi®cation al., 1994; van der Geer et al., 1996; Gotoh et al., of Gads, a novel adaptor protein most similar to Grb2 1996; Harmer and DeFranco, 1997). The Grb2 SH3 and Grap that contains amino and carboxy terminal domains mediate its stable association with the Ras SH3 domains ¯anking a central SH2 domain and a 120 guanine nucleotide exchange factor, Sos, and mem- amino acid unique region.
[Show full text]
The Clinical Aspect of Adaptor Molecules in T Cell Signaling: Lessons Learnt from Inborn Errors of Immunity
MINI REVIEW published: 12 August 2021 doi: 10.3389/fimmu.2021.701704 The Clinical Aspect of Adaptor Molecules in T Cell Signaling: Lessons Learnt From Inborn Errors of Immunity Yael Dinur-Schejter 1,2,3*, Irina Zaidman 1,2, Hagar Mor-Shaked 1,4 and Polina Stepensky 1,2 1 Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel, 2 The Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah Ein Kerem Medical Center, Jerusalem, Israel, 3 Allergy and Clinical Immunology Unit, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel, 4 Monique and Jacques Roboh Department of Genetic Research, Hadassah Ein Kerem Medical Center, Jerusalem, Israel Adaptor molecules lack enzymatic and transcriptional activities. Instead, they exert their function by linking multiple proteins into intricate complexes, allowing for transmitting and ﬁne-tuning of signals. Many adaptor molecules play a crucial role in T-cell signaling, following engagement of the T-cell receptor (TCR). In this review, we focus on Linker of Edited by: Activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 KDa (SLP- Anne Spurkland, 76). Monogenic defects in these adaptor proteins, with known roles in T-cell signaling, University of Oslo, Norway have been described as the cause of human inborn errors of immunity (IEI). We describe Reviewed by: Martha Jordan, the current knowledge based on defects in cell lines, murine models and human patients. University of Pennsylvania, Germline mutations in Adhesion and degranulation adaptor protein (ADAP), have not United States resulted in a T-cell defect. Stephen Charles Bunnell, Tufts University School of Medicine, Keywords: adaptor molecules, ADAP, LAT, SLP-76, T-cell signaling, primary immune deﬁciency United States *Correspondence: Yael Dinur-Schejter [email protected] INTRODUCTION Specialty section: Engagement of the T cell receptor (TCR) triggers a signaling cascade responsible for T-cell This article was submitted to activation, maturation and differentiation.
[Show full text]
The Breakpoint Region of the Most Common Isochromosome, I(17Q), In
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Am. J. Hum. Genet. 74:1–10, 2004 The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats Aikaterini Barbouti,1,* Pawel Stankiewicz,2,* Chad Nusbaum,5 Christina Cuomo,5 April Cook,5 Mattias Ho¨glund,1 Bertil Johansson,1 Anne Hagemeijer,6 Sung-Sup Park,2,† Felix Mitelman,1 James R. Lupski,2,3,4 and Thoas Fioretos1 1Department of Clinical Genetics, Lund University Hospital, Lund, Sweden; Departments of 2Molecular and Human Genetics and 3Pediatrics, Baylor College of Medicine, and 4Texas Children’s Hospital, Houston; 5Whitehead Institute for Biomedical Research/Massachusetts Institute of Technology, Center for Genome Research, Cambridge, MA; and 6Department of Human Genetics, University of Leuven, Leuven, Belgium Although a great deal of information has accumulated regarding the mechanisms underlying constitutional DNA rearrangements associated with inherited disorders, virtually nothing is known about the molecular processes involved in acquired neoplasia-associated chromosomal rearrangements. Isochromosome 17q, or “i(17q),” is one of the most common structural abnormalities observed in human neoplasms. We previously identiﬁed a breakpoint cluster region for i(17q) formation in 17p11.2 and hypothesized that genome architectural features could be responsible for this clustering. To address this hypothesis, we precisely mapped the i(17q) breakpoints in 11 patients with different hematologic malignancies and determined the genomic structure of the involved region. Our results reveal a complex genomic architecture in the i(17q) breakpoint cluster region, characterized by large (∼38–49-kb), palindromic, low-copy repeats, strongly suggesting that somatic rearrangements are not random events but rather reﬂect susceptibilities due to the genomic structure.
[Show full text]
BGGN 213 Interpretation of a Wide Range of Biological Data
Recap From Last Time: • Bioinformatics is computer aided biology. ‣ Deals with the collection, archiving, organization, and BGGN 213 interpretation of a wide range of biological data. • There are a large number of primary, secondary and tertiary Foundations of Bioinformatics bioinformatics databases (see handout!). • The NCBI and EBI are major online bioinformatics service providers. Barry Grant • Introduced Gene, UniProt and PDB databases as well as a number of ‘boutique’ databases including PFAM and OMIM. • Introduced the notion of controlled vocabularies and ontologies via exploring GO annotations. http://thegrantlab.org/bggn213 • Also covered: Course structure; Introductions, Software setup and Database Vignette… Example Vignette Questions: TODAYS MENU • What chromosome location and what genes are in the vicinity of a • More hands-on exploration of these databases and their given query gene? NCBI GENE associated tools (searching with a propose!) • What can you ﬁnd out about molecular functions, biological • Major hands-on sections include: processes, and prominent cellular locations? EBI GO 1. BLAST, GenBank and OMIM @ NCBI [~35 mins] • What amino acid positions in the protein are responsible for ligand 2. GENE database @ NCBI [~15 mins] binding? EBI UniProt — BREAK — • What variants of this gene are associated with gastric cancer and 3. UniProt & Muscle @ EBI [~25 mins] other human diseases? NCBI OMIN 4. PFAM, PDB & NGL [~30 mins] — BREAK — • Are high resolution protein structures available to examine the 5. Optional extension exercises [~20 mins] details of these mutations? How might we explain their potential molecular effects? RCSB PDB • What is known about the protein family, its species distribution, ‣ Please do answer the last review question (Q19).
[Show full text]