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LC Laboratories® Preclinical Oncology REAGENTS FOR SIGNAL TRANSDUCTION RESEARCH, THERAPEUTIC DiscoVERY AND Preclinical OncologY Aug CATALOG/HANDBOOK 2014 LC Laboratories® LOOK HERE FIRST TM for: • The Most Important Signaling/Oncology Compounds GY • The Highest Purities and We reduce product prices whenever possibleabs.com – pleasefor current always prices visit • The Lowest Prices www.LCL COLO TM ON LOOK HERE FIRST for: • > 60 Kinase Inhibitors • Obatoclax • AICAR, Free Base • Okadaic Acid • Bafilomycin A1 – Prices Reduced - (11/13) • Olaparib • Bortezomib – Prices Reduced - (11/13) • Oxaliplatin ICAL • Cabazitaxel – Prices Reduced - (6/14) • Paclitaxel N • Calyculin A • PD 98059 • Crizotinib – Prices Reduced - (10/13) • PKC412 • Cyclopamine • PMA (Phorbol 12-Myristate 13-Acetate) CLI • Docetaxel • Rapamycin • Doxorubicin • Staurosporine • Everolimus • Temsirolimus • FK-506 • Tofacitinib PRE • Foretinib • Trametinib • GDC-0941 • Vemurafenib – Prices Reduced - (6/14) • Gemcitabine • Vinblastine • Lapatinib • Vincristine • Linsitinib – Prices Reduced - (12/13) • Vismodegib • NVP-BEZ235 • Wortmannin th Our 34 Year GLOBAL ONE-PRICING — our U.S. home 34 1980 – 2014 office ships directly to almost all countries www.LCLabs.com (800) 937-3720 Outside the U.S.: 1-781-937-0777 • In-stock Products and Sizes are Shipped within 1 Business Day of Order Entry Completion (Subject to Credit Approval) • Shipped by Next-day Delivery to All U.S. Destinations All shipments to U.S. addresses are automatically sent by overnight service for afternoon arrival. For most packages, the shipping charge is $29. Our Promise to You We don’t waste your grant/budget funds: • No T-shirts • No mugs, no pens • No 4-color catalogs or newsletters (very expensive to print!) • No advertisements in journals • No booths at trade shows • No salespeople in the hallways of your institution • No special “Sale” or “Discount” gimmicks • No pricey outside contractors to build our website • No marketing or promotional phone calls to researchers After all, your grant or budget pays for these components of reagent costs! Just the Essentials ... • Important, widely-used compounds • Highest purities available See the following pages for more about our products and • Lowest prices available their very high purity áand low prices IF you do signal transduction, oncology or other preclinical research, THEN you have probably been relying on LC Labs products, directly or indirectly, from the time you started your research (unless you started more than ~34 years ago) In Business for 34 Years - Since 1980, manufacturing and selling directly and through many distributors and other reagent-vendor customers worldwide, LC Laboratories has provided the biomedical research community with some of its most important small-molecule reagents. Even if you just found our website or catalog today for the first time, you have probably used one or many of our top-quality, widely-used products over the years, via purchases from any of our numerous reagent-vendor customers under their labels (some of these firms have merged or been acquired)*: • Sigma • Biotrend • Enzo • RBI • Calbiochem • Biovision • Life Technologies • Santa Cruz • Alexis/Axxora • Cascade • LKT Labs • Tocris • Alomone • Cayman • MP Biomedical • Upstate • Anawa • Cell Signaling • Millipore • Wako • Ascent Technology • Molecular Probes • Many Others • Biomol • Chemicon • Promega Consider the ultimate level of customer testimonials: namely, the enduring confidence in LC Labs that many other reagent vendors — including a number of large, famous, highly reputable firms respected the world over — have demonstrated by buying many hundreds of thousands of vials’ worth of our products during the past 34 years*: • Bafilomycin A1 • FK-506 • LY 294002 • Staurosporine • Brefeldin A • Forskolin • Okadaic Acid • Thapsigargin • BIM I (GF 109203X) • Genistein • PD 98059 • U0126 • Bryostatin 1 • Gö 6976 • Phorbols (PMA/TPA) • Wortmannin • Calyculin A • H89 • PKC412 • Many Others • Chelerythrine • HA-1077 • Prostratin • Cyclopamine • K252a • Rapamycin • Daidzein • K252c • Resiniferatoxin • Equol • Leptomycin B • SB 202190 • Fasudil • Lestaurtinib • SB 203180 Relying on tens of thousands of publications: not only might you have used LC Labs’ products for many years yourself, you have also undoubtedly relied on data reported in the tens of thousands of publications that used our products, purchased directly from us or under our wholesale customer’s labels, during the past 34 years. * The company names listed above are respective trademarks owned by the respective companies. LC Laboratories is independent of, and not affiliated with, these companies except to the extent they are or have been customers of LC Laboratories. The information presented here is not intended to imply (i) that any given company listed above has purchased any particular product listed above from LC Laboratories, nor (ii) that LC Laboratories is or has been the sole source of any particular product listed above for any given company listed above. An Unparalleled Record of Innovation for Major Signal Transduction Reagents: 1980 LC Labs becomes the primary worldwide source of high-purity, low-cost PMA (phorbol 12-myristate 13-acetate; TPA), and this has continued without uninterruption for 33 years — more than 150,000 vials sold 1989 LC Labs provides the first high-purity, low-costThapsigargin to the research market 1990 first high-purity, low-costOkadaic Acid 1991 first high-purity, low-costCalyculin A —and we remain the primary worldwide source for this widely-used phosphatase inhibitor 1995 first isomerically pure, low-costG ö 6976 1996 first high-purity, low-costBafilomycin A1 2002 first high-purity, low-costR apamycin 2002 first high-purity, low-costFK -506 2003 first high-purity, low-costLeptomycin B 2004 first high-purity, low-costStaurosporine 2004 first high-purity, low-cost Cyclopamine 2007 LC Labs introduces the first group of high-purity, low-cost major Protein Kinase Inhibitors for prelinical oncology and related research Continued on next page á Purity and Price Are Not Correlated! The prices charged by biomedical reagent vendors for a given product tell you nothing about the purity. For example, as shown in our Purity/Price Comparison Table for Rapamycin (please visit www.LCLabs.com; Cat. No. R-5000) you can pay: • $173 to Abcam for 1 mg of 98% pure rapamycin • $235 to R&D Systems for 1 mg of 98% pure rapamycin • $296.50 to Sigma for 1 mg of 95% pure rapamycin • $209 to Calbiochem for 1 mg of 98% pure rapamycin - or - • $53 to LC Labs for 50 mg of >99% pure rapamycin! Another example is cyclopamine: • Among the many cyclopamine suppliers, 19 suppliers charge $18 to $193 for 1 mg; 12 of those suppliers make a purity claim of only 98%, and another 4 claim only 97% - or - • LC Labs’ price for 25 mg of >99% pure cyclopamine is $84 — 1/5 to 1/64 of the cost from other major suppliers Please visit www.LCLabs.com and peruse some of our other Purity/Price Comparison Tables. The picture is clear—price tells you nothing about quality. In Business for 34 Years – Since 1980 Table of Contents Topic Pages Biological Activity Index .........................................................................................i Disposal Codes .................................................................................................... iv General Information and Conditions of Sale ........................................................v Product Descriptions and Prices ................................................................... 1-129 Catalog Number Index ............................................................... Inside back cover Biological Activity Index Adenylate Cyclase Activators G-4500 Geldanamycin ..............................................................46 F-9929 Forskolin ......................................................................44 G-4177 Gemcitabine, Hydrochloride Salt ................................46 I-5508 Imatinib, Methanesulfonate Salt..................................54 Alcohol Dehydrogenase Inhibitors I-5900 Ingenol 3-Angelate ......................................................55 D-2946 Daidzein .......................................................................26 I-4122 Irinotecan .....................................................................57 D-7878 Daidzin .........................................................................26 L-4804 Lapatinib, Di-p-Toluenesulfonate Salt.........................63 L-6307 Lestaurtinib ..................................................................64 AMP Protein Kinase (AMPK) Activator M-7007 Masitinib, Free Base ....................................................68 A-1803 A-769662 .......................................................................1 M-2433 Mocetinostat, Free Base .............................................69 Anthracycline Antibiotics M-5602 Mubritinib, Free Base ..................................................71 D-4000 Doxorubicin, Hydrochloride Salt .................................33 N-6404 Neratinib ......................................................................71 N-8207 Nilotinib, Free Base .....................................................72 Anti-Cancer Compounds N-9077 Nintedanib, Free Base .................................................72 A-6880 17-AAG ...........................................................................1 N-4288 NVP-BEZ235, Free Base .............................................75 A-3465 Alvocidib (Flavopiridol) ..................................................6
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