PARD6A (Human) IP-WB Antibody Pair

PARD6A (Human) IP-WB Antibody Pair Catalog # : H00050855-PW1 規格 : [ 1 Set ] List All Specification Application Image Product This IP-WB antibody pair set comes with one antibody for Immunoprecipitation-Western Blot Description: immunoprecipitation and another to detect the precipitated protein in western blot. Reactivity: Human Quality Control Immunoprecipitation-Western Blot (IP-WB) Testing: Immunoprecipitation of PARD6A transfected lysate using rabbit polyclonal anti-PARD6A and Protein A Magnetic Bead (U0007), and immunoblotted with mouse polyclonal anti-PARD6A. Supplied Antibody pair set content: Product: 1. Antibody pair for IP: rabbit polyclonal anti-PARD6A (300 ul) 2. Antibody pair for WB: mouse polyclonal anti-PARD6A (50 ul) Storage Store reagents of the antibody pair set at -20°C or lower. Please aliquot Instruction: to avoid repeated freeze thaw cycle. Reagents should be returned to - 20°C storage immediately after use. MSDS: Download Applications Immunoprecipitation-Western Blot Protocol Download Gene Information Entrez GeneID: 50855 Gene Name: PARD6A Gene Alias: PAR-6A,PAR6,PAR6C,PAR6alpha,TAX40,TIP-40 Gene par-6 partitioning defective 6 homolog alpha (C. elegans) Description: Omim ID: 607484 Gene Ontology: Hyperlink Page 1 of 2 2016/5/23 Gene Summary: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq Other Tax-interacting protein 40,par-6 partitioning defective 6 homolog Designations: alpha,partitioning defective-6 homolog alpha,partitioning-defective protein 6 Gene Pathway Endocytosis Tight junction Related Disease Alzheimer Disease Alzheimer disease Cardiovascular Diseases Diabetes Complications Diabetes Mellitus, Type 2 Hypoglycemia Metabolic Syndrome X Neoplasms Osteoporosis 服務條款 | 隱私權政策 | 著作及商標 | 網站地圖 ©2016 亞諾法生技股份有限公司 Abnova Corporation. 版權所有. Page 2 of 2 2016/5/23.

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Regulation of Cdc42 and Its Effectors in Epithelial Morphogenesis Franck Pichaud1,2,*, Rhian F
© 2019. Published by The Company of Biologists Ltd | Journal of Cell Science (2019) 132, jcs217869. doi:10.1242/jcs.217869 REVIEW SUBJECT COLLECTION: ADHESION Regulation of Cdc42 and its effectors in epithelial morphogenesis Franck Pichaud1,2,*, Rhian F. Walther1 and Francisca Nunes de Almeida1 ABSTRACT An overview of Cdc42 Cdc42 – a member of the small Rho GTPase family – regulates cell Cdc42 was discovered in yeast and belongs to a large family of small – polarity across organisms from yeast to humans. It is an essential (20 30 kDa) GTP-binding proteins (Adams et al., 1990; Johnson regulator of polarized morphogenesis in epithelial cells, through and Pringle, 1990). It is part of the Ras-homologous Rho subfamily coordination of apical membrane morphogenesis, lumen formation and of GTPases, of which there are 20 members in humans, including junction maturation. In parallel, work in yeast and Caenorhabditis elegans the RhoA and Rac GTPases, (Hall, 2012). Rho, Rac and Cdc42 has provided important clues as to how this molecular switch can homologues are found in all eukaryotes, except for plants, which do generate and regulate polarity through localized activation or inhibition, not have a clear homologue for Cdc42. Together, the function of and cytoskeleton regulation. Recent studies have revealed how Rho GTPases influences most, if not all, cellular processes. important and complex these regulations can be during epithelial In the early 1990s, seminal work from Alan Hall and his morphogenesis. This complexity is mirrored by the fact that Cdc42 can collaborators identified Rho, Rac and Cdc42 as main regulators of exert its function through many effector proteins.
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