7th icBEST & 9th isDDRHD, SZU, 2018
Organized by
Shenzhen University Health Science Center, Shenzhen, China
Guangdong Key Laboratory for Genome Stability and Disease Prevention, Shenzhen, China
Shenzhen University Carson International Cancer Center, Shenzhen, China
Zhejiang University, Hangzhou, China
Innovation Team of Immunotherapy Targeting Cancer Stem Cell (Peacock
project of Shenzhen), Shenzhen, China
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany
Cell Signal Transduction Committee, Chinese Society for Cell Biology, Shanghai, China
Shenzhen Luohu Hospital Group
Hosted by
Shenzhen University, Shenzhen, China
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7th icBEST & 9th isDDRHD, SZU, 2018
Joint Presidents of the icBEST/isDDRHD-2018
Dr. Wei-Guo Zhu, President of the SZU Health Science Center
Dr. Qingquan Li, President of the SZU
Co-organizers
Dr. Xingzhi (Xavier) Xu, Guangdong Key Laboratory for Genome Stability & Disease Prevention, SZU Health Science Center, Shenzhen, China
Dr. Zhenkun Lou, Department of Oncology, Mayo Clinic, Rochester, MN, USA
Dr. Zhao-Qi Wang, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany
Dr. Yuejin Hua, Zhejiang University, Hangzhou, China
Secretaries
Ms. Weiyao Qiu ([email protected], Tel:+86-13622393288)
Ms. Chenxi Wang ([email protected], Tel: +86-13652412295)
Contact Details
Guangdong Key Laboratory for Genome Stability & Disease Prevention
Shenzhen University School of Medicine
Rm. A6-810, Xili Campus
1066 Xueyuan BLV
Shenzhen, China
Tel: 0086-755-86930275 (office)
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Speakers & Session Chairs
Keith W. Caldecott University of Sussex, UK Judith L. Campbell California Institute of Technology, USA Zee-Fen Chang National Taiwan University Benjamin Chen University of Texas Southwestern Medical Center at Dallas, USA Ines Chen Chief Editor, Nature Structure & Molecular Biology Junjie Chen University of Texas M. D. Anderson Cancer Center, USA Yongbin Chen Kunming Institute of Zoology, CAS, China Weimin Ci Beijing Institute of Genomics, CAS, China Alan D. D’Andrea Harvard Medical School, USA Anthony Davis University of Texas Southwestern Medical Center at Dallas, USA Marco Foiani IFOM, Italy Daming Gao Institute of Biochemistry and Cell Biology, CAS, China Caixia Guo Beijing Institute of Genomics, CAS, China Ian D. Hickson University of Copenhagen, Denmark Junjie Hu Institute of Biophysics, CAS, China Yuejin Hua Zhejiang University, China Jun Huang Zhejiang University, China Harm Kampinga University Medical Hospital Groningen, the Netherlands Jan Karlseder The Salk Institute, USA Daochun Kong Peking University, China Stephen Kowalczykowski University of California at Davis, USA Li Lan Harvard Medical School, USA Chuan-Yuan Li Duke University, USA Feng Li Wuhan University, China Guo-Min Li University of Texas Southwestern Medical Center at Dallas, USA Lei Li University of Texas M. D. Anderson Cancer Center, USA Qing Li Peking University, China Shisheng Li Louisiana State University, USA 3
7th icBEST & 9th isDDRHD, SZU, 2018
Baohua Liu Shenzhen University, China Cong Liu Sichuan University, China Xiangyu Liu Shenzhen University, China Huiqiang Lou Chinese Agriculture University, China Zhenkun Lou Mayo Clinic, USA Peter J McKinnon St. Jude Children’s Research Hospital, USA Paul Modrich Duke University, USA Kyungjae Myung Ulsan National Institute of Science & Technology, Korea Huadong Pei George Washington University School of Medicine, USA Feng Rao Southern University of Science & Technology, China Kanaga Sabapathy National Cancer Centre Singapore, Singapore Zhiyuan Shen Rutgers Cancer Institute of New Jersey, Rutgers University, USA Yosef Shiloh Tel Aviv University, Israel Vinay Tergaonkar Institute of Molecular and Cell Biology, Singapore Dong Wang University of California at San Diego, USA Hailin Wang Research Center for Eco-Environmental Sciences, CAS, China Hailong Wang Capital Normal University, China Jiadong Wang Peking University, China Weidong Wang National Institute on Aging, NIH, USA Zhao-Qi Wang Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Germany Stephen West Francis Crick Institute, UK Song Wu Shenzhen Luohu Hospital Group, China Xiaohua Wu The Scripps Research Institute, USA Bing Xia Rutgers Cancer Institute of New Jersey, Rutgers University, USA Fen Xia University of Arkansas for Medical Sciences, USA Dongyi Xu Peking University, China Guo-Liang Xu Institute of Biochemistry and Cell Biology, CAS, China Xingzhi Xu Shenzhen University, China Yanhui Xu Fudan University, China 4
7th icBEST & 9th isDDRHD, SZU, 2018
Wei Yang NIDDK, National Institutes of Health, USA Xiaochun Yu City of Hope National Medical Center, USA Jian Yuan Tongji University East Hospital, China Zhi-Cao Yue Fuzhou University, China Youwei Zhang Case Western Reserve University, USA Xiaolan Zhao Memorial Sloan-Kettering Cancer Center, USA Ping Zheng Kunming Institute of Zoology, CAS, China Bin-Bing Zhou Shanghai Jiao Tong University, China Ping-Kun Zhou Beijing Institute of Radiation Medicine, AMMS, China Wei-Guo Zhu Shenzhen University, China
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Meeting venue
The meeting will be held at Auditorium No.1, Science & Technology Building, 3688 Nanhai Boulevard, Shenzhen. The building is within the main campus of Shenzhen University, and is ~1200 meters east of the Sentosa Hotel-Taoyuan Branch.
Map and directions
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Language The official language of the symposium is English.
Arrival For those arriving at Shenzhen Baoan Airport, you can take a taxi to the Sentosa Hotel-Taoyuan Branch, which takes ~40 min and costs approximately RMB 70 Yuans. Alternatively, you can take the subway line 11 at the airport to Qianhaiwan (前海湾) station (three stops), where you transfer to the subway line 1 to Taoyuan (桃园) station (three stops), take the exit A, heading east along Taoyuan Road for about 400 meters and turning left along Nanguang (南光) Road for another 60 meters, the hotel is on your left. This takes ~45 min and costs approximately RMB 6 Yuans. For those arriving at Hong Kong International Airport earlier than 8:00 pm, the most convenient option to reach Shenzhen is by the SkyPier ferry (the terminal is within the airport, with tickets available at baggage reclaim) to Shekou Port, Shenzhen. The trip takes ~30 min and costs approximately RMB 300 Yuans. We then recommend you take a taxi to the Sentosa hotel, which takes ~20 min and costs approximately RMB 30 Yuans. If you arrive later than 8:00 pm, you should take a taxi directly to the Sentosa hotel, which takes ~1.5 h and costs approximately RMB 800 Yuans. We recommend that you print the following information and present it to the taxi driver.
Please take me to Sentosa Hotel, at the cross of Taoyuan Road and Nanguang Road. Tel: 86-755-26039888 请把我带到桃园路和南光路交叉口的圣陶沙酒店桃园店 电话：86-755-26039888
Hotel: 1. All invited speakers and session chairs have pre-paid accommodation at the Sentosa Hotel-Taoyuan Branch (Tianxia International Center, at the cross of Taoyuan Road and Nanguang Road, Tel: 86-755-26039888, http://www.shengshahotel.cn/). The Sentosa Hotel consists of high-class, international executive apartments, and is a 15-min walk from the symposium venue. All rooms offer double beds with air-conditioning, free internet access, and a free buffet breakfast for guests.
Please note that domestic and international phone calls can be made from your room at your own cost.
The exchange rate as of October 3rd 2018 is ~100 EUR = RMB 795 Yuan; ~100 USD 7
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= RMB 687 Yuan.
2. Other recommendations: Grand View Hotel-Taoyuan Branch (No. 10 Taoyuan East Road, Nanshan District, Shenzhen, near the intersection of Nanshan Avenue, at the exit A of Taoyuan subway Station.), a four star hotel with complete facilities, which is next door to the Sentosa Hotel-Taoyuan Branch Sentosa Hotel-Emerald Branch (Emerald Pearl Garden, No. 1, Jinji Road, Nanshan District, Shenzhen, http://fc.sentosahotel.cn/index.aspx), a high-grade international executive apartment, which is a 20-minute walk away from the symposium venue. Shenzhen New Year Hotel (No. 3003 Nanhai Avenue, Nanshan District, Shenzhen, near the exit E2 of Nanshan Railway Station.)，a four star hotel nearby the Shenzhen University with complete facilities.
Hotel Reservation:
We don't provide hotel booking service for delegates, please reserve the hotel by yourself in advance. However, Special rates of these hotels have been arranged for all other attendees. Use the code “icBEST/DDRHD-2018” at the time of reservation to receive conference discounted rates.
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Price Contact Hotel (breakfast Phone Email address Person included) 10.31-11.1 858/night (single bfst) 858/night (double Nan Dai 18938882539 [email protected] Sentosa Hotel- bfst) Lili Chen 18938882530 [email protected] Taoyuan Branch 11.2-11.4 558/night (single bfst) 638/night (double bfst) 10.31 448/night (double Grand View Hotel- bfst) Yinjuan Li 13714232839 [email protected] Taoyuan Branch 11.1-11.4 548/night (double bfst) 10.31-11.1 880/night (single bfst) 980/night (double Sentosa Hotel- bfst) Jinying Liang 18938892059 [email protected] Emerald Branch 11.2-11.4 638/night (single bfst) 718/night (double bfst) 10.31-11.4 Shenzhen New 368/night(single bfst) Yiwei Wang 13724364263 [email protected] Year Hotel 388/night(double bfst)
Conference registration
1. Graduate students and post-doctoral researchers: RMB 1,000 Yuan (or US$170) before Aug. 15th, 2018; RMB 1,250 Yuan (or US$200) before Sept. 15th, 2018; RMB 1,500 (or US$250) after Sept. 15th, 2018 and on site; 2. Faculty members: RMB 1,500 Yuan (or US$250) before Aug. 15th, 2018; RMB 1,750 Yuan (or US$280) before Sept. 15th, 2018; RMB 2,000 (or US$330) after Sept. 15th, 2018 and on site.
The registration desk is open at the lobby of the Sentosa Hotel-Taoyuan Branch between 08:00-21:00 on Nov. 1st, and at the meeting venue between 07:20-10:00 on Nov. 2nd.
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If you arrive at the hotel earlier or later than these times, please check in at the hotel first and then contact Ms. Chenxi Wang (mobile phone: +86-13652412295 ) to arrange your registration.
Conference presentations
Software: It is recommended that participants use Microsoft PowerPoint for their presentation. Special needs should be arranged with the symposium secretaries in advance.
Presentation files: PC-based presentations should be fully compatible on the computers in the auditorium. If your file is prepared on a Mac, please make sure that it is compatible with a PC. We recommend that you upload your presentation files to the auditorium computer before your session begins.
Timings: Each regular talk should be 15 min plus an additional 3 min for discussion, while each short talk has 12+3 minutes.
Weather conditions
The weather in Shenzhen in November is very pleasant with a temperature ranging from 20-30oC and the air quality is one of the best in China.
Traveling in Shenzhen
Shenzhen is a modern, financial and commercial metropolis in China, located in the southern portion of the Guangdong Province and lies adjacent to Hong Kong. Shenzhen's prime location has given it a geographical advantage for economic development. In 1980, Shenzhen was designated the first Special Economic Zone (SEZs) of China. Since then, the city has rapidly developed and expanded and today is a renowned highlight of China. This bustling city is home to ~20 million people, and is famous for its rapid economic growth.
The beautiful scenery and beaches are highlight of Shenzhen, and places worth visiting are the Xiaomeisha Beach Resort, Yangmeikeng valley and Dongchong beach.
Shenzhen is a young city, with a 40-year history, and as such does not have as many historical attractions as other famous cities in China. However, its excellent theme parks and man-made scenic spots have succeeded in attracting many tourists. The Window of the World is a theme park featuring miniature-scale famous landmarks from every corner of the world. The Splendid China - Folk Culture Village introduces its visitors to the history, culture, art, ancient architecture, customs and habits of the
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various regions of China. Shenzhen Happy Valley is a large, modern theme park that features “Spanish Square”, “Cartoon City”, “Mt. Adventure”, “Gold Mine Town”, “Shangri-la Woods”, “Sunshine Beach”, “Typhoon Bay”, “Playa Maya Water Park” and “Happy Times”, and provides ~100 exciting games for both adults and children. Other attractions include: Shenzhen Dapeng Fortress, OCT East Shenzhen, Sea World, Shenzhen Fairy Lake Botanical Garden, Wutong Mountain and Xiaomeisha Sea World.
Public transportation
All suburbs and the central business districts in Shenzhen are served with public transportation networks including the subway, buses, and taxi.
Subway (Metro): Shenzhen has nine subway lines that operate from 06:30 to 23:00. Trips on the subway cost between RMB 3-10 Yuan, based on distance travelled. For those wanting to travel to the central area of Shenzhen, the subway is a convenient, cheap, and fast option.
Bus: The bus networks cover every corner of the city and each trip costs RMB 1-10 Yuan. However, the bus networks are complicated to navigate and the buses are often very crowded. We do not recommend that you choose this option for your travels around Shenzhen.
Taxi: Taxis in Shenzhen are a very convenient mode of transport. For trips into the urban districts of Shenzhen, you must take a taxi that is colored red. You cannot ride in a taxi that is colored green. Taxis cost RMB 11 Yuan for the first 2 km and then an additional RMB 2.4 Yuan per km. Taxis taken between 23:00-06:00 cost an additional 20%. Passengers are also required to pay a fuel surcharge (RMB 1-3 Yuan) and any tolls or parking fees.
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Scientific Program (*: selected from the submitted abstracts)
Auditorium No.1, Science & Technology Building, Shenzhen University
Nov. 1st, 2018 (Thursday) 10:00-20:00 Registration: Lobby, Shenzhen Sentosa Hotel-Taoyuan Branch
16:00-18:00 Keynote speeches: Chairs, Wei-Guo Zhu and Xingzhi Xu 16:00-16:10 Chen Xu, Shenzhen University, China Welcome speech
16:10-17:10 Paul Modrich, Duke University Medical Center, Durham NC, USA Mechanisms in human DNA mismatch repair Introduced by Dr. Wei-Guo Zhu
17:10-18:10 Stephen West, Francis Crick Institute, UK Making Ends Meet Introduced by Dr. Xingzhi Xu
18:30-20:30 Dinner for all the attendees at the faculty cafeteria (100 meter south to the auditorium) Welcome reception for the invited speakers only at the 4th floor of the Sentosa Hotel-Taoyuan Branch
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Nov. 2nd, 2018 (Friday) 07:30-11:00 Registration: Lobby, Auditorium no. 2, Science & Technology Building, Shenzhen University main campus
08:30-09:00 Opening ceremony and group photo: Xingzhi Xu, Wei-Guo Zhu, Zhenkun Lou, Yuejing Hua,
09:00-10:45 Session 1: DNA damage signaling I Chairs: Baohua Liu and Marco Foiani 9:00-9:18 Alan D’Andrea, Dana-Farber Cancer Institute, Harvard Medical School, USA Regulation of Double Strand Break End Resection 9:18-9:36 Xiaochun Yu, City of Hope National Medical Center, USA NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression 9:36-9:54 Yanhui Xu, Fudan University, China Structural Insight into DNA damage response mediated by PIKK family kinases 9:54-10:12 Xingzhi Xu, Shenzhen University, China MRE11 UFMylation promotes ATM activation 10:12-10:30
Li Lan, Harvard Medical School, USA ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination *10:30-10:45 Xiangyu Liu, Shenzhen University School of Medicine, China 13
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Role of CtIP in lymphocyte development
10:45-11:05 Coffee break
11:05-12:32 Session 2: DNA repair I Chairs: Huiqiang Lou and Alan D’Andrea 11:05-11:23 Marco Foiani, IFOM, Italy Mechanisms coordinating replication with transcription 11:23-11:41 Dong Wang, University of California at San Diego, USA Structural Basis of Eukaryotic Transcription-Coupled Repair Initiation 11:41-11:59 Daming Gao, Institute of Biochemistry and Cell Biology, CAS, China mTOR sensitizes genome to growth signals 11:59-12:17 Baohua Liu, Shenzhen University, China A Synergistic Action of Sirtuins Promotes DNA Damage Response and DNA Repair *12:17-12:32 Youwei Zhang, Case Western Reserve University School of Medicine, USA Protective roles of 53BP1 independent of the DSB repair function
12:32-14:00 Lunch at the faculty cafeteria (100 meter south to the auditorium) and poster viewing Chairs of the Poster Award Committee: Junjie Chen and Yuejin Hua
12:45-13:45
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Meet the editor at the coffee shop next to the auditorium Ines Chen, PhD, Chief Editor, Nature Structure & Molecular Biology (An admission ticket can be picked up at the registration desk on a first come, first served basis)
13:40-14:00 XinPin Zhuang, TissueGnostics Asia Pacific Limited Tissue cytometry and its application in repair of DNA damage
14:00-15:45 Session 3: Chromosome replication I Chairs: Ping Zheng and Bing Xia 14:00-14:18 Kyungjae Myung, Ulsan National Institute of Science & Technology, Korea ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress 14:18-14:36 Bin-Bing Zhou, Shanghai Jiao Tong University School of Medicine, China Replication Stress Drives Convergent Evolution during Treatment of PRPS1 Mutant-Relapsed ALL 14:36-14:54 Xiaohua Wu, The Scripps Research Institute, USA Break-induced DNA replication and long track gene conversion in mammalian cells 14:54-15:12 Judith Campbell, California Institute of Technology, USA Regulation of DNA2 nuclease/helicase by FANCD2 15:12-15:30 Junjie Hu, Institute of Biophysics, CAS, China ER-mitochondria contact and stress signaling 15:30-15:45
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Hailong Wang, Capital Normal University, Beijing, China PLK1 targets CtIP to promote microhomology-mediated end joining
15:45-16:05 Coffee break
16:05-18:41 Session 4: DNA damage signaling II Chairs: Dongyi Xu and Stephen West 16:05-16:23 Stephen Kowalczykowski, University of California at Davis, USA Molecular Functions of BRCA1 in Homologous Recombination 16:23-16:41 Zee-Fan Chang, Institute of Molecular Medicine, National Taiwan University NA methyltransferase 3b deficiency causes transcription-dependent DNA damage in centromeres via endonucleases in nucleotide excision repair to drive chromosome instability 16:41-16:59 Pingkun Zhou, Beijing Institute of Radiation Medicine, AMMS, China Rbx1 restricts homologous recombination repair of DNA double-strand break in G1 phase through prompting ubiquitination and degradation of EXO1 protein 16:59-17:17 Feng Li, Wuhan University, China Histone demethylase promotes DNA damage by activating long interspersed nuclear element-1 (LINE-1)
17:17-17:35
Yuejin Hua, Zhejiang University, China Structural basis of 5′ flap recognition and protein-protein interactions of human flap endonuclease 1 *17:35-17:50 Feng Rao, Southern University of Science & Technology, China
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DNA damage response mediated by Inositol phosphate metabolites and their synthases *17:50-18:05 Shisheng Li, Louisiana State University, USA Genome-wide CRISPR/Cas9 knockout screening identifies novel genes and biological processes implicated in cisplatin resistance 18:05-18:23 Cong Liu, Sichuan University, China The anti-resection activity of the X protein encoded by Hepatitis Virus B 18:23-18:41 Vinay Tergaonkar, Institute of Molecular and Cell Biology, Singapore Mammalian Rap1 regulates DNA damage signaling
19:10-21:00
Welcome dinner at the 2nd floor of the Grand View Hotel Shenzhen-Nanshan Taoyuan Headquarter（深圳新桃园酒店 南山桃园总店, 100 meters east to the Sentosa Hotel-Taoyuan Branch）
Nov. 3rd, 2018 (Saturday) 8:30-10:30 Session 5: Chromosome replication II Chairs: Song Wu and Vinay Tergaonkar 8:30-8:48 Ian D. Hickson, University of Copenhagen, Denmark Defining how problematic DNA replication impacts on chromosome segregation 8:48-9:06 Bing Xia, Rutgers Cancer Institute of New Jersey, Rutgers University, USA BRCA2 regulates DNA replication and intra-S phase checkpoint response through an interaction with the essential replication factor MCM10 9:06-9:24 Weimin Ci, Beijing Institute of Genomics, CAS, China
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Larger scale genomic aberrations characterize metastatic renal cell carcinoma evolution 9:24-9:42 Yongbin Chen, Kunming Institute of Zoology, CAS, China The beauty of interdisciplinary study between evolutionary biology and tumor biology 9:42-10:00 Xiaolan Zhao, Memorial Sloan-Kettering Cancer Center, USA Learning about genome duplication mechanisms from cancer mutations *10:00-10:15 Huiqiang Lou, Chinese Agriculture University, China A new S phase checkpoint effector *10:15-10:30 Zhi-Cao Yue, Fuzhou University, China Keratin 17 regulates p53-dependent transcription and G2/M transition in ionizing radiation-induced skin damage
10:30-10:50 Coffee break
10:50-12:53 Session 6: DNA damage response Chairs: Zee-Fen Chang and Ian Hickson 10:50-11:08 Jian Yuan, Tongji University East Hospital, China The role of the BRD9-Rad51 axis in Chemoresistance in Ovarian Cancer 11:08-11:26 Dongyi Xu, Peking University, China NAIF1-constituted nucleoskeleton suppresses chromosome translocation and tumorigenesis 11:26-11:44
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Hailin Wang, Research Center for Eco-Environmental Sciences, CAS, China Unsaturated RecA filaments drive flanked strand separation for three-strand exchange 11:44-12:02 Caixia Guo, Beijing Institute of Genomics, CAS, China RNA-splicing factor SART3 regulates translesion DNA synthesis 12:02-12:20 Huadong Pei, George Washington University School of Medicine and Health Science Center, USA The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors *12:20-12:35 Benjamin Chen, The University of Texas Southwestern Medical Center, USA Coordination Between DNA-PKcs and ATR in Cellular Response to Replication Stress 12:35-12:53 Kanaga Sabapathy, National Cancer Centre Singapore, Singapore Therapeutic targeting of P53
13:00-14:00 Lunch at the faculty cafeteria (100 meter south to the auditorium)
14:30-16:00 Tour the Shenzhen University School of Medicine at the Xili campus Please sign up at the registration desk
15:30-20:00 City tour (RMB 200 per person, dinner is included) Please sign up and pay to the travel agent at the registration desk
Nov. 4th, 2018 (Sunday) 8:30-10:45
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Session 7: Chromosome replication III Chairs: Zhi-Cao Yue and Kyungjae Myung 8:30-8:48 Wei Yang, NIDDK, National Institutes of Health, USA Structures and operating principles of a replisome 8:48-9:06 Ping Zheng, Kunming Institute of Zoology, CAS, China Stem cell-specific factor Filia plays key roles in preserving genomic stability 9:06-9:24 Lei Li, The University of Texas M. D. Anderson Cancer Center, USA Fanconi Anemia and DNA Replication Stress 9:24-9:42 Jan Karlsedar, The Salk Institute, USA Autophagic cell death restricts chromosomal instability during replicative crisis 9:42-10:00 Weidong Wang, National Institute on Aging, NIH, USA Type IA topoisomerases can act on both DNA and RNA; and prevent genome instability and mental disorders 10:10-10:30 Daochun Kong, Peking University, China The effect of DNA replication in chromatin structure *10:30-10:45 Anthony Davis, The University of Texas Southwestern Medical Center, USA Ablating Ku70 phosphorylation results in defective DNA damage repair in human and mouse models
10:45-11:05 Coffee break
11:05-12:35
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Session 8: DNA repair II Chairs: Ping-Kun Zhou and Zhenkun Lou 11:05-11:23 Guoliang Xu, Institute of Biochemistry and Cell Biology, CAS & Fudan University, China A vitamin C-derived DNA modification catalyzed by a TET-related oxidase mediates epigenetic regulation of photosynthesis 11:23-11:41 Jun Huang, Zhejiang University, China Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and function 11:41-11:59 Chuan-Yuan Li, Duke University, USA Unexpected roles of DNA double strand break repair factors in carcinogenesis and maintaining tumorigenicity 11:59-12:17 Jiadong Wang, Peking University, China Acetylation of 53BP1 Dictates the DNA Double Strand Break Repair Pathway 12:17-12:35 Guo-Min Li, The University of Texas Southwestern Medical Center, USA Impact of Histone Modifications and Mutations on Mismatch Repair
12:35-13:30 Lunch at the faculty cafeteria (100 meter south to the auditorium)
13:30-15:00 Session 9: Genome Instability & Disease Chairs: Jiadong Wang and Jan Karlseder 13:30-13:48 Zhao-Qi Wang, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Germany Non-canonical function of NBS1 regulates neuronal homeostasis
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13:48-14:06 Peter McKinnon, St. Jude Children’s Research Hospital, USA Pathogenic Topoisomerase I Activity and the DNA Damage Response in Neurologic Disease 14:06-14:24 Fen Xia, University of Arkansas for Medical Sciences, USA SIRT2 prevents cisplatin-induced neuron injury by promoting nucleotide excision repair 14:24-14:42 Harm Kampinga, University Medical Hospital Groningen, the Netherlands Collapse in protein homeostasis is a crucial intermediate of genome instability related neurodegeneration 14:42-15:00 Zhiyuan Shen, Rutgers Cancer Institute of New Jersey, Rutgers University, USA Radiation-induced tumorigenesis in Bccip haplo-insufficient mice
15:00-15:20 Coffee break
15:20-16:50 Session 10: DNA damage signaling III Chairs: Qing Li and Zhao-Qi Wang 15:20-15:38 Junie Chen, The University of Texas M. D. Anderson Cancer Center, USA Regulation of DNA damage response and tumorigenesis 15:38-15:56 Zhenkun Lou, Mayo Clinic, USA The Regulation of DNA-Protein Crosslinks 15:56-16:14 Keith W. Caldecott, University of Sussex, UK
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A Novel Role for Poly(ADP-ribose) Polymerase Activity During Normal Cellular Metabolism 16:14-16:32 Wei-Guo Zhu, Shenzhen University, China SIRT7 is a key regulator for ATM inactivation 16:32-16:50 Yosef Shiloh, Tel Aviv University, Israel New layers in the cellular response to DNA double-strand breaks 16:50-17:00 Poster awards and closing remarks Announcement of isDDRHD-2019 (10th anniversary celebration) and icBEST-2020
17:30-19:30
Buffet dinner at the 1st floor of Grand View Hotel Shenzhen-Nanshan Taoyuan Headquarter（深圳新桃园酒店 南山桃园总店, 100 meters east to the Sentosa Hotel-Taoyuan Branch）
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