Clinical Chemistry and Laboratory Medicine

CLINICAL CHEMISTRY AND LABORATORY MEDICINE Published in Association with the International Federation of Clinical Chemistry and Laboratory Medicine and the European Federation of Clinical Chemistry and Laboratory Medicine

CCLM is the official journal of the Association of Clinical Biochemists in Ireland (ACBI), the Belgian Society of Clinical Chemistry (BVKC/SBCC), the German United Society for Clinical Chemistry and Laboratory Medicine (DGKL), the Hungarian Society of Laboratory Medicine (MLDT), the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC), the Korean Society of Clinical Chemistry (KSCC), the Slovenian Association for Clinical Chemistry (SZKK), the Spanish Society for Clinical Biochemistry and Molecular Pathology (SEQC), and the Turkish Biochemical Society (TBD).

EDITOR-IN-CHIEF EDITORIAL BOARD Naziha Kaabachi José M. Queraltó Mario Plebani Marianne Abi Fadel Tunis, Tunisia Barcelona, Spain Padova, Italy Beirut, Lebanon Jeong-Ho Kim Marileia Scartezini Francisco V. Alvarez Seoul, Korea Curitiba, Brazil Oviedo, Spain Wolfgang Korte Ana-Maria Simundic ASSOCIATE EDITORS Hassan M.E. Azzazy St. Gallen, Switzerland Zagreb, Croatia Giuseppe Lippi Cairo, Egypt Christos Kroupis Gregory J. Tsongalis Reviews Editor Eleftherios P. Diamandis, Athens, Greece Lebanon, USA Parma, Italy Toronto, Canada Leslie Charles Lai Pierre Wallemacq Philippe Gillery Arnold von Eckardstein Kuala Lumpur, Malaysia Brussels, Belgium Shengkai Yan Reims, France Zurich, Switzerland W.K. Christopher Lam Beijing, China Emmanuel Favaloro Shatin, Hong Kong Steven Kazmierczak Ian S. Young Westmead, Australia Portland, USA Janja Marc Belfast, UK Karl J. Lackner Andrea Griesmacher Ljubljana, Slovenia Mainz, Germany Innsbruck, Austria Eiji Miyoshi MANAGING EDITOR Bohuslav Melichar Wolfgang Herrmann Osaka, Japan Heike Jahnke Homburg/Saar, Germany Tomris Özben Olomouc, Czech Republic Berlin, Germany Johannes J.M.L. Hoffmann Antalya, Turkey Gérard Siest Nuenen, Netherlands Vladimir Palicka Perspectives Editor Herbert Hooijkaas Hradec Králové, Nancy, France Rotterdam, Netherlands Czech Republic John B. Whitfield Kiyoshi Ichihara Mauro Panteghini Brisbane, Australia Ube, Japan Milan, Italy ABSTRACTED/INDEXED IN Indexed in Academic OneFile (Gale/Cengage Learning); Analytical Abstracts; Biochemistry & Biophysics Citation Index; Biological Abstracts; BIOSIS Previews; CAB Abstracts and Global Health; Chemical Abstracts and the CAS databases; Current Contents/Life Sciences; CSA Illustrata – Natural Sciences; Elsevier BIOBASE/Current Awareness in Biological Sciences (CABS); EMBASE, the Excerpta Medica database; EMBiology; Index Medicus/MEDLINE; ISI Custom Information Services; Journal Citation Reports/Science Edition; Science Citation Index; Science Citation Index Expanded (SciSearch); and Scopus.

CCLM is Published in Association with the International Federation of Clinical Chemistry and Laboratory Medicine and the European Federation of Clinical Chemistry and Laboratory Medicine. CCLM is the official journal of the Association of Clinical Biochemists in Ireland (ACBI), the Belgian Society of Clinical Chemistry (BVKC/SBCC), the German United Society for Clinical Chemistry and Laboratory Medicine (DGKL), the Hungarian Society of Laboratory Medicine (MLDT), the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC), the Korean Society of Clinical Chemistry (KSCC), the Slovenian Association for Clinical Chemistry (SZKK), the Spanish Society for Clinical Biochemistry and Molecular Pathology (SEQC), and the Turkish Biochemical Society (TBD).

The publisher, together with the authors and editors, has taken great pains to ensure that all information presented in this work (programs, applications, amounts, dosages, etc.) reflects the standard of knowledge at the time of publication. Despite careful manuscript preparation and proof correction, errors can nevertheless occur. Authors, editors and publisher disclaim all responsibility for any errors or omissions or liability for the results obtained from use of the information, or parts thereof, contained in this work. The citation of registered names, trade names, trademarks, etc. in this work does not imply, even in the absence of a specific statement, that such names are exempt from laws and regulations protecting trademarks etc. and therefore free for general use.

ISSN 1434-6621 ∙ e-ISSN1437-4331 ∙ CODEN CCLMFW

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RESPONSIBLE EDITOR(S) Prof. Dr. Prof. Mario Plebani, Università di Padova, Dipartimento di Medicina di Laboratorio, Azienda Ospedaliera di Padova, Via Nicolo Giustiniani 2, 35131 Padova, Italy. Tel.: +390 (0)49 821 2792, Fax: +390 (0)49 663 240, Email: [email protected]

JOURNAL MANAGER Heike Jahnke, De Gruyter, Genthiner Straße 13, 10785 Berlin, Germany, Tel.: +49 (0)30 260 05 – 220, Fax: +49 (0)30 260 05 – 325, Email: [email protected]

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TYPESETTING Compuscript Ltd., Shannon, Ireland

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Printed in Germany

COVER ILLUSTRATION Research lab © Eisenhans. Permission to use the image on the cover granted by Fotolia LLC. Clin Chem Lab Med 2012;50(2):189–410; A1–A69, © 2012 by Walter De Gruyter • Berlin • Boston

CONTENTS

EDITORIALS Evaluation of Maxwell® 16 for automated DNA extraction from whole blood and formalin-fixed Biological variation and reference change values: an paraffin embedded (FFPE) tissue essential piece of the puzzle of laboratory testing Shama Khan Khokhar, Midori Mitui, Nora Kristine Leos, Mario Plebani and Giuseppe Lippi 189 Beverly Barton Rogers and Jason Y. Park 267

Copeptin for acute coronary syndrome: diamond Screening for mutations in the a-globin genes or decoy? leading to abnormal hemoglobin variants with Andreas Luchner 191 high resolution melting analysis Refers to article on p 243 Ying-Na Liu, Ru Li, Jian-Ying Zhou, Xing-Mei Xie, Jian Li, Can Liao and Dong-Zhi Li 273

Alternative methods to a TaqMan assay to detect REVIEWS a tri-allelic single nucleotide polymorphism rs757210 in the HNF1b gene Gold nanoparticles in the clinical laboratory: Jesse J. Swen, Renee F. Baak-Pablo, Henk-Jan Guchelaar principles of preparation and applications and Tahar van der Straaten Hassan M.E. Azzazy, Mai M.H. Mansour, Tamer M. 279 Samir and Ricardo Franco 193 Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) –482C>T polymorphism on The physiology and pathobiology of human triglyceride concentration in Turkish adults kallikrein-related peptidase 6 (KLK6) Neslihan Coban, Altan Onat, Filiz Guclu-Geyik, Jane Bayani and Eleftherios P. Diamandis 211 Evrim Komurcu-Bayrak, Vedat Sansoy, Gulay Hergenc, Günay Can and Nihan Erginel-Unaltuna 285

MINI REVIEW Angiotensin converting enzyme (ACE) insertion/ deletion (I/D) polymorphism and circulating ACE From “Clinical Proteomics” to “Clinical Chemistry levels are not associated with outcome in critically Proteomics”: considerations using quantitative ill septic patients mass-spectrometry as a model approach Argirios Tsantes, Iraklis Tsangaris, Petros Kopterides, Sylvain Lehmann, Pauline Poinot, Laurent Tiers, Christophe Georgios Nikolopoulos, Eleni Kalamara, Georgios Junot, François Becher and Christophe Hirtz 235 Antonakos, Violetta Kapsimali, Argiri Gialeraki, Ioanna Dimopoulou, Stylianos Orfanos, Kleanthi Dima, Anthi Travlou and Apostolos Armaganidis 293 OPINION PAPER Detection of internal tandem duplications in the Considerations for early acute myocardial infarction FLT3 gene by different electrophoretic methods rule-out for emergency department chest pain Tamás Bubán, Katalin Koczok, Róza Földesi, Gabriella patients: the case of copeptin Szabó, Andrea Sümegi, Miklós Tanyi, László Szerafin, Giuseppe Lippi, Mario Plebani, Salvatore Di Somma, Miklós Udvardy, János Kappelmayer and Péter Valter Monzani, Marco Tubaro, Massimo Volpe, Paolo Antal-Szalmás 301 Moscatelli, Arialdo Vernocchi, Mario Cavazza, Marcello Galvani, Piero Cappelletti, Giancarlo Marenzi, Simona Functional polymorphisms of GSTA1 and GSTO2 Ferraro, Alberto Lombardi and Andrea Peracino 243 genes associated with asthma in Italian children Sara Piacentini, Alberto Verrotti, Renato Polimanti, Cosimo Giannini, Patrizia Saccucci, Dario Manfellotto PERSPECTIVES and Maria Fuciarelli 311

Do genome-wide association scans have potential GENERAL CLINICAL CHEMISTRY AND LABORATORY for translation? MEDICINE Margarida C. Lopes, Eleftheria Zeggini and Kalliope Panoutsopoulou 255 Optimisation of whole blood and plasma manganese assay by ICP-MS without use of a collision cell Claire Richardson, Edward Roberts, Simon Nelms and GENETICS AND MOLECULAR DIAGNOSTICS Norman B. Roberts 317

Strategies of reducing input sample volume for Quantitative performance of antibody array extracting circulating cell-free nuclear DNA and technology in a prenatal screening setting mitochondrial DNA in plasma Wendy Rodenburg, Johan H. Reimerink, Sandra Imholz, Weijie Chen, Fengfeng Cai, Bei Zhang and Gert-Jan Godeke, Jeroen L.A. Pennings, Peter C.J.I. Xiao Yan Zhong 261 Schielen, Maria P.H. Koster and Annemieke de Vries 325 iv Contents

A comparison of the acute effects of calcium and CARDIOVASCULAR DISEASES strontium ranelate on the serum marker of bone resorption Heart type fatty acid binding protein in relation Kristyna Brabnikova Maresova, Tomas Franek, to pharmacologic scintigraphy in coronary artery Tomas Vondracek and Jan J. Stepan 333 disease Eftihia Sbarouni, Panagiota Georgiadou, Maria Koutelou, A new dot immunoassay for simultaneous detection Mihas Constantinos, Antigoni Chaidaroglou, Demitris of celiac specific antibodies and IgA-deficiency Degiannis and Vassilis Voudris 387 Karsten Conrad, Dirk Roggenbuck, Annelore Ittenson, Dirk Reinhold, Thomas Buettner and Martin W. Laass 337 Effects of fibrates on C-reactive protein concentrations: a meta-analysis of randomized Preferentially immunoglobulin (IgG) subclasses controlled trials production in primary Sjögren’s syndrome patients Yongchen Hao, Huan Zhang, Xueli Yang, Lu Wang and Yudong Liu and Jinming Li 345 Dongfeng Gu 391

Development of control material for hemoglobin analysis LETTERS TO THE EDITOR Sakorn Pornprasert, Kunyakan Kongthai, Jarurin Waneesorn, Kanokwan Jaiping and Kallayanee Comparison of Bio-Plex measurements with Treesuwan 351 standard techniques Sandra Ribeiro, Henrique Nascimento, Ana Borges, Evaluation of nucleated red blood cells in the Maria do Sameiro Faria, Petronila Rocha-Pereira, peripheral blood of hematological diseases Elísio Costa, Luís Belo and Alice Santos-Silva 399 Paolo Danise, Mariacaterina Maconi, Fabio Barrella, Anna Di Palma, Daniela Avino, Adele Rovetti, Maria Interference of hemoglobin (Hb) Las Palmas with Gioia and Giovanni Amendola 357 HPLC measurement of HbA1c in 87 patients Mercedes Lorenzo-Medina, Silvia De La Iglesia, Paloma The effect of hematocrit on the results of Ropero, Mercedes Navarro-Romero, Ruth Martín-Alfaro measurements using glucose meters based on and Carmen Guindeo-Casasús 403 different techniques Bogdan Solnica, Jan Skupien, Beata Kusnierz-Cabala, False-positive calcitonin results in patients with Krystyna Slowinska-Solnica, Przemyslaw Witek, benign goiter Agnieszka Cempa and Maciej T. Malecki 361 Luca Giovanella, Sergio Suriano, Fabio Cattaneo and Massimo Bongiovanni 407 Lupus anticoagulant testing: analyzing fresh samples after a single centrifugation and after a 6–8 h delay Paul Froom and Mira Barak 367 ERRATUM

Pseudoeosinophilia of synovial fluid is caused by Heterophilic antibody interference in commercial crystals mimicking the distinct light scattering immunoassays; a screening study using paired fractions of eosinophilic granules native and pre-blocked sera Christoph Robier, Franz Quehenberger, Manfred Nils Bolstad, David J. Warren, Johan Bjerner, Gunnhild Neubauer, Mariana Stettin and Franz Rainer 371 Kravdal, Lutz Schwettmann, Kari H. Olsen, Pål Rustad and Kjell Nustad 409 The effect of acidification and oxalate concentration on urine calcium measurements in EQAS materials and patient samples CONGRESS ABSTRACTS Adriaan J. van Gammeren, Corrie van Haperen and Aldy W.H.M. Kuypers 375 Advances and Controversies in B-Vitamins and Choline Leipzig, Germany, March 5-8, 2011 A1 CANCER DIAGNOSTICS

The multi-cancer marker, rs6983267, located at region 3 of chromosome 8q24, is associated with prostate cancer in Greek patients but does not contribute to the aggressiveness of the disease Amalia Papanikolopoulou, Olfert Landt, Konstantinos Ntoumas, Stefanos Bolomitis, Stavros I. Tyritzis, Constantinos Constantinides and Nikolaos Drakoulis 379

Due to a technical error, the DOI 10.1515/CCLM.2011.740 was unfortunately assigned to two articles in CCLM issue 1, 2012 (Ceriotti et al., p 67; Ellina et al., p 167). The new DOI for the article by Elina et al. reads correctly: DOI 10.1515/CCLM.2011.881.