Finding Better Treatments and a Cure for Recurrent Prostate Cancer: Winter 2004 Progress Report
• Detection, Diagnosis and Prognosis PCF-Funded Scientist Prostate Cancer Foundation of Prostate Cancer Aaron Ciechanover Releases Its First Annual Report • Local Treatment of Prostate Cancer • Androgen Deprivation Therapy Awarded Nobel Prize for Prostate Cancer to the Nation on Prostate Cancer The Prostate Cancer Foundation is pleased • Management of Bone Metastases to honor Aaron Ciechanover, M.D., winner in Patients with Prostate Cancer n addition to being the world’s leading source of philanthropic of the 2004 Nobel Prize in Chemistry and Isupport for prostate cancer research, the Prostate Cancer • Chemotherapeutic Options in a recipient of multiple research grants Patients with Prostate Cancer Foundation (PCF) is also one of the leading sources of information from the Prostate Cancer Foundation. • Emerging Therapies for Prostate Cancer about progress toward better treatments and a cure for recurrent The PCF has provided Dr. Ciechanover • Management of Side Effects in with research grants each year since 2000 prostate cancer and a leading force in accelerating that progress. Prostate Cancer Therapy to investigate the application of his research to the development of new therapies for • Nutrition and Prevention Strategies for prostate cancer. Dr. Ciechanover has On September 22, the Prostate Cancer to gain a clearer understanding of how to Prostate Cancer Foundation introduced a new publication work together to provide prostate cancer reported on these investigations at several designed to increase the base of knowledge patients with optimal care. The Report • Therapeutic Strategies for Patients with of the PCF’s annual Scientific Retreats, about prostate cancer: The Report to the also features important “calls to action” a Rising PSA: A Case-Based Approach including the 2004 Retreat held in October. Nation on Prostate Cancer. The Report for prostate cancer researchers to address Although the Report is primarily targeted The Nobel Foundation recognized is designed to increase knowledge among unanswered scientific questions and for to physicians, well-informed patients and Dr. Ciechanover’s work in illuminating physicians about leading approaches healthcare providers to focus on important caregivers may find the Report interesting the significance of the cellular machine to the treatment of prostate cancer. and valuable as well. issues related to disease management. called the proteasome, which regulates Supported by the PCF’s Pharmaceutical the destruction of unneeded cell proteins. Industry Roundtable, the Report provides Two world-renowned cancer researchers The Report is available online at www.prostatecancerfoundation.org and a comprehensive overview of the state- served as executive editors: Peter R. The proteasome is the target of the drug is being distributed in print to more than of-the-art in the diagnosis, treatment Carroll, M.D., professor and chair of the Velcade, which is approved for use in 20,000 physicians who treat patients and prevention of prostate cancer and Department of Urology at University of treating multiple myeloma and is being with prostate cancer. sets a clear research agenda for the future. California at San Francisco, and William tested for use in treating prostate cancer. G. Nelson, M.D., Ph.D., professor, The PCF has also provided crucial fund- With authors from a wide array of Following a media launch at the New Departments of Oncology, Urology, ing to support the clinical development specialties, the Report supports the concept York Academy of Sciences, a Continuing Pharmacology, Medicine and Pathology of Velcade. of a multidisciplinary approach to the Medical Education (CME)-certified live at The Johns Hopkins University. symposium was held, with more than management of prostate cancer. The PCF “The Prostate Cancer Foundation salutes 120 tristate area physicians in attendance. intends the Report to be used by all those Following an introduction by the execu- Dr. Aaron Ciechanover and congratulates An additional 300 physicians participated involved in the care of prostate cancer tive editors, the Report is comprised of him for winning the Nobel Prize in via a live webcast on Medscape.com patients—including urologists, medical nine chapters written by 22 prostate Chemistry. His discovery of the critical (the webcast will remain available at oncologists and radiation oncologists— cancer thought leaders. The chapters are: importance of the proteasome is crucial Medscape.com for one year), and in the to the development of new therapies for first week alone, more than 15,000 prostate cancer,” said Leslie D. Michelson, healthcare providers viewed the Report vice chairman and CEO of the Prostate chapters on the Medscape site. Each Cancer Foundation. “The PCF funded of the nine chapters of the Report are Dr. Ciechanover through its Israel also available as a CME activity on Initiative, which is part of our worldwide Medscape.com/prostatecancer. effort to harness the talents of the best The Report has already generated and brightest in the fight for better treat- significant media coverage from Time ments and a cure for recurrent prostate magazine, USA Today, NBC News, CBS cancer,” he added. News, the Washington Times, CNN.com, BusinessWeek Online and Health News Daily, among others. Inside This Issue The PCF gratefully acknowledges the support of Abbott Laboratories, Aventis, Novartis and Sanofi-Synthelabo, the founding members of the PCF’s From the CEO 2 Pharmaceutical Industry Roundtable, Board News 2 which supported this initiative and helped to defray the costs of producing the Report. Science Update 3 The content of the Report was developed Lifestyle 4 entirely by the Report’s authors with no Peter T. Scardino, M.D., chair of the Department of Urology and head of the prostate cancer editorial input from the members of the Recipe 5 program at Memorial Sloan-Kettering Cancer Center (left); Daniel P. Petrylak, M.D., associate Roundtable in any manner. professor of medicine at Columbia University College of Physicians & Surgeons (center); and News 6 –7 Peter R. Carroll, M.D., professor and chair, UCSF Department of Urology (right), answer questions at a media briefing regarding the PCF’s Report to the Nation on Prostate Cancer Events 7 held at the New York Academy of Sciences on September 22, 2004. Calendar 8 Leadership 8
1 www.prostatecancerfoundation.org 310.570.4700 From the CEO Publications Board News
s part of our ongoing program to keep you The Prostate Cancer Foundation Earle I. Mack Named Ambassador Ainformed about our progress, we want to tell you publishes many publications each year to the Republic of Finland that highlight news and features about President George W. Bush has confirmed about some important developments in our quest to the Foundation’s support of prostate Prostate Cancer Foundation board find better treatments and a cure for recurrent prostate cancer research, programs, treatment member Earle I. Mack to be Ambassador cancer. In short, this has been one of the best periods projects, clinical trials, studies, resources Extraordinary and Plenipotentiary of the ever for scientific accomplishments, fund-raising and and successful PCF partnerships. United States of America to the Republic of Finland. Well-connected in both visibility for this cause. Here are some highlights: Nobody Knows business and political circles, Mr. Mack Few people realize that prostate cancer has been a PCF board member since is the most common non-skin cancer in Science 2003, and was a senior partner and chief America, striking more than 230,000 financial officer for the nearly century-old • Over the past few years, we have funded research intended to identify men each year. The PCF has updated its Mack Company. The firm, headquartered informative booklet entitled Nobody surrogate endpoints for prostate cancer clinical trials so that the trials can in Rochelle Park, New Jersey, invests, Knows to raise prostate cancer awareness. be conducted more rapidly, with fewer patients, less expense and clearer develops and manages income-producing results. This research has matured to the point that on June 21 and 22, commercial real estate. Mr. Mack has a long track record of success in business, the FDA convened a workshop attended by over 250 people to determine and is a leading philanthropist supporting the optimal way to proceed. the arts, education and cancer research.
• We provided multiple research grants to Aaron Ciechanover, M.D., to President George W. Bush has support his investigation of the proteasome and possible applications to Report to the Nation confirmed Prostate Cancer prostate cancer. For his groundbreaking work in this area, Dr. Ciechanover The Report to the Nation on Prostate Cancer Foundation board member was awarded the 2004 Nobel Prize in Chemistry. is a comprehensive overview of the state- of-the-art in the diagnosis, treatment and Earle I. Mack to be Ambassador Fund-raising prevention of prostate cancer. Extraordinary and Plenipotentiary We set records from our June fund-raising programs centered around of the United States of America Father’s Day: to the Republic of Finland. • Safeway once again demonstrated the strength of its commitment to the community by raising close to $3.4 million in its annual point-of-purchase At the 2001 New York Dinner, the PCF honored Earle Mack along with his program in all 1,800 Safeway, Vons, Pavilions, Dominick’s, Randalls, Tom brothers, David, Bill and Fred, for their Thumb, Genuardi’s and Carrs stores. widespread philanthropy that includes, in addition to support of the Prostate • Our eighth annual Home Run Challenge in conjunction with Major Cancer Foundation, major gifts to the League Baseball generated more than $2 million as hundreds of people PCF NewsPulse Long Island Jewish Health System, whose around the country made donations. The Prostate Cancer Foundation has North Shore University Hospital was launched NewsPulse, an email newsletter ranked the number one hospital in the • Our newest program, the “Because You Love Him” eBay online auction, that educates individuals about the U.S. by the AARP. latest news and information regarding raised more than $200,000. More than 400 items were auctioned off, includ- “I am grateful for the leadership and prostate cancer. ing lunch with pop star Avril Lavigne and dinner with Miss Universe 2004, guidance Earle Mack has given the Jennifer Hawkins, both of which sold for more than $16,000. The support Prostate Cancer Foundation over the years. His contribution to the PCF will from the eBay community of buyers and sellers was gratifying and established be missed and I wish him continued a solid foundation for dramatically expanding this program next year. success in this next phase of his life as a public servant of the United States of Visibility America,” said PCF founder and chairman Mike Milken. Although awareness alone will not result in better treatments for patients Annual Report Mr. Mack was sworn in as Ambassador to fighting prostate cancer, it helps to expand our donor base and harness The 2003 Annual Report summarizes Finland on May 28, 2004. more of society’s resources for this cause. Thus, we worked hard to get the PCF’s accomplishments and focuses our message out. on the PCF’s pivotal role in research, the latest drugs in development and • At our suggestion and with our support, NBC’s Today show featured partnerships with major corporations prostate cancer as the health issue for an entire week. Public figures like Safeway and AriZona Beverages. battling prostate cancer, including PCF chairman Mike Milken, Secretary of State Colin Powell, singer-actor Mandy Patinkin, retired U.S. Army general Norman Schwarzkopf and former New York mayor Rudy Giuliani, were interviewed, as were many of our most productive physician-scientists.
We are proud of these accomplishments because we know that they hasten the day when prostate cancer will be merely a sad memory. As always, we appreciate your ongoing support.
Very truly yours, If you would like to sign up to receive these FREE publications, visit www.prostatecancerfoundation.org and enter the search word “PCF Publications” or contact us at 1.800.757.CURE. Leslie D. Michelson Vice Chairman and Chief Executive Officer
2 www.prostatecancerfoundation.org 310.570.4700 FDA Holds First-Ever Workshop on PCF Launches Pharmaceutical Prostate Cancer Clinical Endpoints Industry Roundtable
One of the main obstacles to making Recognizing the vital role the pharma- • Promote and conduct prostate more prostate cancer treatments available ceutical industry plays in the fight to cancer research. to patients is the lack of accepted “clinical find better treatments and a cure for • Advocate for the accelerated approval endpoints” for prostate cancer drug trials, recurrent prostate cancer, the Prostate of promising treatments that have been other than patient survival. Currently, Cancer Foundation has launched the proven to be safe and effective in large increased survival time is the key endpoint Pharmaceutical Industry Roundtable. clinical trials. accepted by the FDA to prove the efficacy The Roundtable is designed to bring of a proposed prostate cancer drug. together many of the leading pharmaceu- • Support development of assertive Because prostate cancer is slow-moving, tical and biotechnology companies treatment guidelines and interdisciplinary this is an endpoint that takes years to committed to the development of effective medical education. reach, making drug development a very therapies for prostate cancer. The PCF • Enhance awareness of prostate cancer lengthy process. The FDA recognizes this welcomes Abbott Laboratories, Aventis, and treatment options. problem and has been working to identify Bristol-Myers Squibb, Novartis and and obtain consensus on earlier markers. Sanofi-Synthelabo as charter members The PCF gratefully acknowledges the of the Roundtable. support of the members of the Roundtable Because the Prostate Cancer Foundation for providing underwriting for the PCF’s is committed to clearing the path to better The goals of the Roundtable are to: annual Scientific Retreat and for the treatments and drugs for prostate cancer, • Reduce barriers to the optimal recently released Report to the Nation on the PCF has placed an extremely high treatment of prostate cancer. Prostate Cancer. priority on the development of new clinical endpoints that would expedite the testing and approval of new drugs. The PCF’s efforts include advocacy as well PCF Co-Sponsors Groundbreaking as research funding. Rather than relying on the results of a single test or marker as an interim end- Prostate Cancer Symposium The PCF is not alone in its desire to see point, there was a great deal of discussion the establishment of intermediate clinical The Prostate Cancer Foundation The 2005 Prostate Cancer Symposium about the use of a composite endpoint. endpoints and surrogate markers. In announces its initiation and sponsorship will offer educational sessions and abstract A composite endpoint would consist of June, the FDA convened the first-ever of the 2005 Prostate Cancer Symposium, presentations on prostate cancer preven- two or more tests or markers that, when “FDA Public Workshop on Clinical Trial the first multidisciplinary symposium tion, screening, diagnosis, multidiscipli- analyzed in tandem, proved to be a reliable Endpoints in Prostate Cancer” in Bethesda, on prostate cancer with co-sponsorship nary treatment and translational research. indicator of the efficacy of a drug. Maryland. More than 250 people attended from the American Society of Clinical The target audience for the symposium the workshop, which featured two days While there was no clear consensus at the Oncology (ASCO), the American Society includes clinicians and researchers study- of presentations and panel discussions. workshop on which single or composite for Therapeutic Radiology and Oncology ing the biology, prevention, epidemiology, Among the 19 speakers were PCF-funded endpoint was the best choice as an interim (ASTRO) and the Society of Urologic diagnosis and multidisciplinary treat- researchers Anthony D’Amico, M.D., Ph.D., endpoint, there was broad agreement ment of prostate cancer. The organizers of the Dana-Farber Cancer Institute that development and acceptance of an By convening the symposium, expect 500 or more attendees, including and Howard I. Scher, M.D., of Memorial interim endpoint was a necessary and medical oncologists, urologists, radiation the sponsors are seeking to Sloan-Kettering Cancer Center. PCF crucial step in the effort to make more oncologists, radiologists, pathologists, representatives at the workshop included drugs and treatments available to prostate encourage more practitioners epidemiologists, pharmacologists, phar- Howard Soule, Ph.D., former executive cancer patients. To that end, a follow-up macists, translational-oriented laboratory to take a multidisciplinary vice president and chief science officer, working group meeting was convened in scientists and nurses. and Gregg Britt, senior vice president, bio- New York in August to establish more approach to prostate cancer By convening the symposium, the pharmaceutical research and development. detailed recommendations regarding treatment. sponsors are seeking to encourage more composite interim endpoints that could One of the main conclusions coming practitioners to take a multidisciplinary be used to help shorten the approval out of the presentations and discussion Oncology (SUO). This conference will approach to prostate cancer treatment, time for effective new therapies. was that great potential exists to establish bring together for the first time leading along the lines of the team approach new “interim” clinical endpoints for The FDA is expected to deliver a detailed urologists, oncologists and radiation taken by physicians treating breast, lung prostate cancer drugs, allowing them to report on the workshop later this year to therapists to discuss ways to accelerate and other cancers. Among the topics that be approved on a conditional basis while the Oncology Drugs Advisory Committee research and improve care by increasing will be covered during the educational the manufacturer continues with post- (ODAC), which reviews applications for collaboration across specialties. The three- sessions will be reports on advances in approval studies to evaluate the treatment cancer drug approvals and makes recom- day symposium will be held February multidisciplinary care of prostate cancer, against the gold-standard endpoint, mendations to the FDA. The PCF will 17–19, 2005 at the Hyatt Grand Cypress including the optimal strategies for increased survival time. continue to be an active participant in this in Orlando, Florida. treating patients with prostate cancer. vital effort. Continued on page 5
Prostate Cancer Glossary
It is important to learn some of the key improvement of the health or survival of search for new treatments. This is why find proven links between observed terminology in the search for better patients following use of the experimental researchers are hard at work to develop changes in PSA levels and survival. treatments and a cure for recurrent drug or treatment. This is the “clinical other accepted clinical endpoints that will Such evidence would be considered prostate cancer. The following are two endpoint” of a drug trial. In prostate cancer, more quickly measure the benefit patients a “surrogate marker” because changes definitions you should know: the most commonly accepted endpoint receive from experimental treatments. in PSA levels are not direct evidence is an improved rate of patient survival, of improved patient health or survival Clinical Endpoint: In order for a new Surrogate Marker: A surrogate marker is measured by the additional number of but foreshadow it. If researchers can drug or treatment to be approved, a clinical endpoint that proves the efficacy months or years added to the lives of the develop acceptable surrogate markers researchers must show government of a drug or treatment earlier because it patients involved in the study. With a for prostate cancer research, it will regulators that it provides a measurable reliably predicts a clinical endpoint, such slow-progressing disease such as prostate dramatically reduce the time needed benefit to patients. The most logical as survival or measurable improvement in cancer, it takes years to reach such a to develop new prostate cancer drugs way to do this is to measure the patient health. For instance, in prostate clinical endpoint, dramatically slowing the and treatments. cancer, researchers are working hard to
3 www.prostatecancerfoundation.org 310.570.4700 Lifestyle
n our last issue, Dr. Peter Gann, of Northwestern University, and pursue an understanding of individual Dr. Gann: Compared to 10 years ago, compounds that may be beneficial, it is we have a lot of leads. What many of us Dr. Elizabeth A.Platz, of The Johns Hopkins Bloomberg School of I also vital to gain insight into the effects are trying to do is tie together all this Public Health, talked about research into nutrition, weight and prostate of the whole food, such as soy. After all, information so that we can create a cancer care. We resume our Q&A to discuss other lifestyle factors no individual compound found in soy, or coherent picture. As laboratory advances any plant, operates in isolation. Plants occur we want to get those results out and the future of prostate cancer research. have evolved over millions of years to into population studies as quickly as develop compounds that interact with possible. The PCF ties into this because Q. We all know smoking is unhealthy, Q. Is there a relationship between one another for biologic purposes. it is such a significant source of funding but is it considered a risk factor for sexual activity and prostate cancer? Therefore, the message I’d like to get for research. As a private organization prostate cancer? across here is that eating the whole food the PCF is in very close contact with the Dr. Gann: This is not an easy thing to gives you the benefit of the interaction scientific community and is extremely Dr. Gann: Most studies show no relation- study for obvious reasons. At this point of all the compounds. responsive to suggestions and feedback. ship insofar as risk is concerned, and in there are no plausible theories that And I should add to the overall picture those that do show a risk it is very slight. suggest a relationship between frequency— Dr. Platz: The Health Professionals Follow- of the future, the increasing role of PSA We do not see the increased risk between or lack of frequency—of ejaculation and up Study at Harvard now has a survival screening, as well as the fact that just smoking and prostate cancer that is pres- prostate cancer. There have also been cohort where Dr. Ed Giovannucci and last year we had the first evidence from ent in lung cancer or heart disease. But studies examining sexually transmitted Dr. June Chan are investigating risk a randomized trial that a drug called while you can’t make the “no smoking” disease and prostate cancer and they did factors for prostate cancer progression finasteride can prevent prostate cancer. recommendation based on prostate not demonstrate a connection. But, as as they study recurrence of the disease. The results of the finasteride study showed cancer, we know that smoking is simply I’m sure Elizabeth will mention because The study, which has been partially funded a significant reduction in prostate cancer not a part of a healthy lifestyle. she is studying this, there is currently a by the PCF, has more than 3,000 men who diagnosis in the group taking the drug lot of interest in the relationship between have had a diagnosis of prostate cancer Dr. Platz: A person looking for reasons for many years compared to those taking prostate cancer and inflammation of the and are now being followed for outcome. to quit, or better still, never to take up the placebo. Even with certain complexities prostate. This is interesting to us because cigarettes at all, should know that tobacco Q. What are you working on right now? of the results, finasteride is clearly a inflammation causes the release of use is implicated in numerous diseases. chemopreventive agent. Though I can’t chemicals in the prostate that have the Dr. Gann: We’re about to begin a study Lung, head and neck, bladder and pan- speak for everyone, I don’t believe there is potential to damage DNA and potentially on tomato extract that will enroll men creatic cancers, as well as cardiovascular consensus as to who should be taking that lead to development of cancer. Chronic at very high risk. These men have high- disease, are among the many health risks drug. But it is so promising that there is no inflammation of the prostate might grade PIN (prostatic intra-epithelial associated with smoking. While there is doubt that there will be new studies in the well be caused by a microbial infection neoplasia), a condition that is considered no relationship between cigarette smoking next few years better defining high-risk such as bacteria or viruses. the premalignant precursor to prostate and the incidence of prostate cancer, there men who should consider finasteride to cancer. This study will look not at the are a number of studies that show a Q. Are there factors being researched prevent the occurrence of prostate cancer. occurrence of cancer, but at whether the significant association between smoking today that might have an impact on tomato extract or placebo have different and death from prostate cancer. We’ve our understanding of recurrence of effects on the prostate tissue itself and also learned that a small number of those prostate cancer? whether those effects look as though studies indicate that it is recent smoking Recommended online resources: Dr. Gann: Epidemiological studies have they are protective or not. history, rather than the cumulative effect revealed interesting nutritional components Prostate Cancer Foundation of many years of tobacco use, that relates Q. Where do you see the future of the from soy products that might prevent www.prostatecancerfoundation.org to death from the disease. research that is going on today? prostate cancer or slow progression of American Cancer Society Q. Does that mean we can tell men that the disease. For example, one of those Dr. Platz: Right now there is a strong www.cancer.org quitting today can reduce their risk of compounds, genistein, is a phytoestrogen focus on inflammation and prostate dying from prostate cancer? —an estrogen-like compound in the soy cancer—inflammation occurs when there National Cancer Institute plant. Estrogen is known to have some are white blood cells moving into an area www.nci.nih.gov Dr. Platz: Certainly, we hope so, but this activity in the treatment of prostate in response to infection or tissue damage. has not been specifically studied. I can Brady Urological Institute at Johns Hopkins cancer. Laboratory studies show that We are beginning to believe that this tell you I was involved with a retrospective www.urology.jhu.edu genistein appears to slow the progression inflammation may increase the risk of study led by Dr. Patrick Walsh at Johns of prostate cancer in experimental models. prostate cancer. Miavita Hopkins—the surgeon who developed Let me add that while it is useful to www.miavita.com the nerve-sparing radical prostatectomy— to evaluate if cigarette smoking was associated with more aggressive disease, and we did find that smoking was associated with prostate cancer in which the tumor had already grown beyond the confines of the prostate. The Prostate Cancer Foundation Launches New Website
Q. What about alcohol consumption? ness and generate funds to accelerate been diagnosed with prostate cancer. research. In addition to serving as a On this page, you can honor that special Dr. Platz: The vast majority of the 60 resource for patients, the PCF will use the person who has faced the challenge of or so studies on the subject say there is site to further simplify and accelerate prostate cancer. no association. But we took a look at how researchers can apply for funds, patterns of alcohol consumption in the • The Report to the Nation on Prostate provide the media and others extensive Health Professionals Follow-up Study Cancer: You can download this 96-page information about prostate cancer and and found that men who drank a large report from the PCF’s home page. the PCF, and include information about volume of alcohol over only one or two our corporate partners and promotions. days of the week had a 60% higher risk Please visit the PCF website at www.prostatecancerfoundation.org of prostate cancer compared to men who Some of the outstanding resources and feel free to give comments or drank less than one day per week or who available to patients include: suggestions to the PCF webmaster at did not drink at all. More research needs The Prostate Cancer Foundation has • The Therapeutics Database, which [email protected]. to be done in this important area. launched a new website to provide patients catalogs all of the therapies under and loved ones comprehensive and easily development for prostate cancer If you are interested in linking your accessible information about prostate including a brief description of each. site to the PCF website, please visit cancer, treatment options, nutrition, www.prostatecancerfoundation.org or lifestyle, risk factors and resources that • The Prostate Cancer Foundation’s email the communications department at can provide assistance. The PCF plans to Monument Park, a memorial and tribute communications@prostatecancerfounda- use the site to help patients, raise aware- virtual park dedicated to people who have tion.org.
4 www.prostatecancerfoundation.org 310.570.4700 Prostate Cancer The Symposium (cont. Soy from page 3) The steering committee for the symposium Connection includes two members of the PCF’s Clinical Research Consortium: Eric Small, M.D., of the UCSF Comprehensive Cancer Center (chair of the symposium steering The soybean was one of the sacred crops of Besides using soy committee), and Kenneth J. Pienta, M.D., the ancient Chinese emperors and it remains sauce as a seasoning, of the University of Michigan Medical Center. The PCF is represented on the the highest-quality protein in the plant world. what other ways are program committee by Dr. Pienta as well as Maha Hussain, M.D., of the University Scientists have theorized that soy protein there to increase your of Michigan, Phillip Kantoff, M.D., of the may help reduce the risk of prostate, as well soy intake? Here are Dana-Farber Cancer Institute (Boston, Massachusetts) and Matthew Smith, M.D., as other, cancers. In fact, the evidence is some suggestions: Ph.D., of Massachusetts General Hospital. significant enough that a petition for such a • Use soy milk on your cereal Registration for the symposium is being handled through ASCO’s website health claim has been submitted to the FDA. or in your morning coffee or tea; at www.asco.org. For more information In addition to carbohydrates, protein and about the symposium, including • Have a soy protein shake for additional sponsorship opportunities, fat, soybeans contain isoflavones, which are contact Gregg Britt, senior vice breakfast or lunch; believed to have anti-cancer properties. president, biopharmaceutical research and development via email at • Substitute soy cheese for regular cheese; [email protected]. Japan, where soy protein intake is significantly higher than in the U.S., has a lower overall • Try miso soup (made with soybean paste) rate of prostate cancer as well as more slowly and edamame (raw green soybeans)— Did you know... progressing cancers. Population studies find they’re delicious! • Prostate cancer is the most common a 34% decreased risk of cancer in countries • Substitute marinated tofu for meat, non-skin cancer in America, striking where soy protein intake averages about 50 230,000 men in 2003. fish or chicken in traditional dishes; • As baby boomer men reach the target zone grams per day. • Experiment with soy-based meat for prostate cancer, beginning at age 50, the number of new cases is projected to substitutes when preparing meals. increase dramatically. By 2015, there will be more than 300,000 new prostate cancer cases each year, a 50% increase.
• Every 18 minutes, a man dies from Taste for Living prostate cancer in the United States.
• Compared to Caucasian men, African American men are 1.5 times more likely to get prostate cancer and 2.3 times As a recurring item in every Preparation more likely to die from prostate cancer. newsletter, the Prostate Cancer Place all ingredients in blender container and Foundation includes a recipe blend thoroughly. • Prostate cancer has the strongest w from our cookbook encouraging familial link of all major cancers. For extra cancer-fighting power, add: you to change your diet 1 teaspoon each of lemon and orange zest without compromising your taste for living. • Every 2 1/2 minutes a man is 3 capsules green tea powder (open capsules and use diagnosed with prostate cancer. powder only) Fruit Shake 1/2 cup brewed green tea instead of 1/2 cup water • African American men have the highest Takes less than 30 minutes incidence of prostate cancer in the world. Nutritional Content Makes one shake Per serving: 265 Calories, 1.7g Fat, 0.2g Saturated Fat, • Your odds of making a hole-in-one Ingredients 0g Cholesterol, 22.1g Protein, 42g Carbohydrate, are 1 in 38,000. Your odds of getting 1/2 cup orange, pineapple, apple or mixed, 3.3g Fiber, 207mg Sodium prostate cancer: 1 in 6. unsweetened fruit juice Credits 1/2 cup water • A man is 33% more likely to get prostate Recipe by celebrity chef Beth Ginsberg, 1/4 cup of frozen berries or cancer than a woman is to get breast cancer. co-author of the Taste for Living Cookbook. frozen fruit of your choice For more information, please contact the Prostate • This year, 30,000 men will lose 1 banana Cancer Foundation at 310.570.4700 or visit our their lives to this deadly disease. 2 scoops of strawberry or plain website, www.prostatecancerfoundation.org. soy protein isolate powder
5 www.prostatecancerfoundation.org 310.570.4700 Is Your PSA Rising?
Men who have been treated for prostate cancer and are still experiencing rising PSA may In the ads, Arnie urges men with a rising PSA to “include an oncologist—a cancer have hormone-resistant prostate cancer, an advanced form of the disease. Yet because specialist—in your treatment discussions. Talk with your urologist about including a of a lack of communication between their urologist and cancer specialists, they may not medical oncologist on your healthcare team. The combined expertise of an urologist receive timely chemotherapy treatment. At this stage of disease, it is more important than and an oncologist will help ensure you receive optimal care.” ever for patients to involve a team of medical specialists—including a urologist, a medical Arnie conducted a “satellite media tour” with news reporters at TV stations around the oncologist and a radiation oncologist. The Prostate Cancer Foundation believes that a U.S. The Prostate Cancer Foundation would like to thank Arnold Palmer and Aventis, multidisciplinary approach to the management of prostate cancer results in optimal care a member of the PCF Pharmaceutical Industry Roundtable, for supporting this campaign. because all therapeutic options can be offered to the patient.
To address this issue and to help promote the concept of a multidisciplinary care team, the PCF rolled out a public service announcement starring Arnold Palmer that debuted in September during Prostate Cancer Awareness month.
Safeway Raises $3.4 Million for eBay “Because You Love Him” Prostate Cancer Research Auction Raises More Than This June, Safeway, one of America’s premier food retailers, demonstrated its commitment $200,000 for the PCF to the communities it serves by once again conducting a successful campaign to raise awareness of, and funds for, prostate cancer research. Led by president and CEO Steve Burd, There are many ways to support the work of the Prostate Cancer Foundation, including Safeway’s 200,000 employees in all 1,820 stores, including Carrs, Dominick’s, Genuardi’s, participating in the exciting “Because You Love Him” online auction. Randalls, Pavilions, Tom Thumb and Vons, used point-of-purchase promotions, candy sales, book sales, auctions and other creative means to raise close to $3.4 million for This summer, the Prostate Cancer Foundation teamed with eBay, The World’s Online prostate cancer research. Since its inception in 2000, the program has generated more Marketplace™, to auction more than 350 items, raising more than $200,000 for research than $8 million for this vital cause. to find better treatments and a cure for recurrent prostate cancer. The “Because You Love Him” auction was successful because generous donors provided “We are in a race against time to find better treatments and a cure for prostate cancer,” scores of valuable auction items and thousands of people bid on them. Among the items said Leslie D. Michelson, vice chairman and CEO of the Prostate Cancer Foundation. auctioned to raise money for the PCF were dinner with Miss Universe 2004, Jennifer “The strong and abiding support of Safeway and its customers will help us win that race.” Hawkins; lunch with pop star Avril Lavigne; a private two-hour visit with former Los Angeles Laker Earvin “Magic” Johnson; an afternoon with golf legend Arnold Palmer; tennis with Donald Trump at his legendary Mar-a-Lago club in Palm Beach; a visit to the set of the hit TV show Las Vegas with star James Caan; lunch with legendary boxing promoter Don King; and dinner with world-renowned skateboarder Tony Hawk.
Wish you would have had a chance to bid on these kinds of items? It’s too late for the 2004 auction, but be sure to check the PCF website next June, when we will announce the 2005 “Because You Love Him” online auction items and details. If you would like to donate an item for the auction, please contact PCF chief operating officer Debbie Bohnett at [email protected].
6 www.prostatecancerfoundation.org 310.570.4700 PCF Announces New Amateur Tennis Program
The Pacific Life Open, an ATP Masters The tournaments are designed for men Open, complimentary hotel rooms, Series Event, has recently partnered with and women players who are members of invitations to both the Friday and Events the Prostate Cancer Foundation to launch a tennis club and have a maximum Saturday evening cocktail and dinner a new amateur doubles program, the National Tennis Rating Program (NTRP) parties, and credentials for the Pacific The PCF conducts and participates in Pacific Life Open Club Championships, rating of 4.0. Players can sign up at their Life Open. In addition, all winners of the many programs aimed at raising not to raise both awareness and funds for participating club as they would for any Pacific Life Open Club Championships only research funding but also public prostate cancer. club-run or -sponsored event. An entry will be recognized on Stadium Court awareness of prostate cancer. fee of $50 per participant ($100 per team) following the Men’s Singles Final of the As of October 2004, players from clubs covers both qualifying competition as Pacific Life Open. across Southern California will compete well as an all-expenses-covered weekend in 40 qualifying amateur club tournaments For more information, or to for each club champion at the Pacific Life for the right to advance and represent schedule a tournament at your Open Club Championships. their tennis club at the Pacific Life Open club, please email tennis program Club Championships, scheduled to be Winning players from each club will coordinator Jessica Niebauer at held during the final weekend of the receive gift certificates toward the [email protected]. Pacific Life Open, March 18 – 20, 2005. purchase of tickets to the Pacific Life
A Night to Remember New Yorkers Can Contribute PCF Home The Niebaum-Coppola Estate Winery in Napa Valley was the setting for to Prostate Cancer Research Run Challenge the 12th anniversary of Cigar Aficionado’s “A Night to Remember.” In total, the Through Tax Form Check-off 2004 evening raised close to $800,000 for prostate cancer research. From left to right: On August 3, 2004, New York Governor medical and research communities and George Pataki signed New York State other organizations in an effort to help Cigar Aficionado editor and publisher Senate Bill 6206A providing for the prevent prostate cancer and save lives. Marvin R. Shanken and his wife, Hazel; new prostate cancer state tax check-off. All New Yorkers owe a debt of gratitude former actress Janet Jones-Gretzky; Beginning with their 2004 tax returns, to Mike Milken for his dedication and Niebaum-Coppola winery owner Francis New Yorkers can now contribute to commitment to this effort.” Ford Coppola; broadcaster Rush prostate cancer research by simply check- Limbaugh; Hall of Fame hockey legend ing off a donation of any amount on their Beginning with their 2004 tax state tax returns. For every dollar Wayne Gretzky; and PCF chairman returns, New Yorkers can now contributed by the taxpayers, the State Michael Milken. Dusty Baker, manager of the Chicago Cubs, of New York and the Prostate Cancer contribute to prostate cancer joins fellow prostate cancer survivor and Foundation have agreed to donate a dollar, research by simply checking PCF chairman Mike Milken in donning so that every dollar donated becomes blue wristbands in support of the 8th three dollars for prostate cancer research. off a donation of any amount Annual Home Run Challenge. This game, The impetus for this bill began at the on their state tax returns. between the Cubs and Astros, was held New York State Roundtable on Prostate at Minute Maid Park in Houston, Texas, Cancer, a meeting of the state’s leading These contributions will be placed in a and was one of 60 designated games cancer experts co-hosted by PCF founder 501(c)(3), the New York Coalition to during Home Run Challenge week. and chairman Mike Milken and New Cure Prostate Cancer, which is dedicated York State Senate Majority Leader Joseph solely to this cause. An independent panel When it comes to raising money to fight Bruno, both prostate cancer survivors. comprised of the top prostate cancer prostate cancer, the Prostate Cancer On the day of the signing, Senator Bruno research scientists will then distribute Foundation has been hitting them out of March 20–21, 2004— said, “I thank Governor George Pataki these funds through a competitive awards the park with the Home Run Challenge 3rd Annual Indian Wells and Assembly Speaker Sheldon Silver for process to research centers throughout (HRC). Now in its eighth year, the PCF Pro-Am Tennis Tournament partnering with the Senate on this critical the State of New York conducting the 2004 Home Run Challenge has teamed Players from across the country paired legislation to unify and harness the most promising research to find better with Major League Baseball and the together to help raise money in the fight efforts, energies and resources of the treatments and a cure for prostate cancer. Major League Baseball Players Association against prostate cancer at the 3rd Annual in a nationwide slugfest that has raised more than $2 million to fund prostate Indian Wells Pro-Am Tennis Tournament. cancer research. From left to right: Hall of Fame hockey legend and tournament champion Wayne Baseball fans everywhere had the oppor- tunity to pledge money for each home Gretzky, businessman Dennis Washington, run hit in 60 preselected games beginning former number four world-ranked tennis on June 11, and ending on Father’s Day, player and tournament champion Jonas June 20. With 132 total home runs hit, Bjorkman and PCF founder and chairman this summer’s HRC sluggers have outdone Mike Milken all participated in the Pro-Am themselves. Tennis Tournament. Dave Perron, managing director of the HRC, still has the enthusiasm of a rookie who has been sent up to the Big Leagues.
“We have participation from every asset of the game, from management to labor—all the owners, the team executives, front office personnel, even the groundskeepers support our work. PCF chairman Mike Milken (third from left) and PCF vice chairman and CEO Leslie D. Every year this great effort is the result Michelson (center) look on as New York Governor George E. Pataki (seated) signs into law of the collaboration of several equally legislation that will create a voluntary check-off box on New York State income tax forms. important elements: the number of Drive for the Cure For every dollar contributed by the taxpayers, the State of New York and the Prostate Cancer donors we get, the level of participation John Nordstrom, actor Hal Linden and Foundation have each agreed to donate a dollar, so that every dollar donated becomes from the general public, and of course, Stan Maron attended the PCF’s Drive for three dollars for prostate cancer research. the number of home runs hit.” the Cure in Cabo San Lucas, Mexico.
7 www.prostatecancerfoundation.org 310.570.4700 Leadership Prostate Cancer Foundation Board of Directors • Michael Milken Arthur Kern Elaine Wynn Funds innovative research that leads to better treatments. Chairman Chairman Co-Chief Executive Officer Prostate Cancer Foundation San Francisco Foundation Wynn Resorts • Puts money in researchers’ hands quickly. Merv Adelson David Koch Stanley Zax Chairman Executive Vice President Chairman and President • Brings together leading academic scientists with biotech and East West Venture Group Koch Industries Zenith National Insurance Corporation pharmaceutical companies and government leaders and researchers. Jim Allchin Shmuel Meitar Group Vice President, Platforms Director Microsoft Corporation Aurec Group • Supports a consortium of the nation’s leading cancer centers. Executive Management James Blair Lori Milken Leslie D. Michelson General Partner Vice President Vice Chairman and • Leads public awareness campaigns about prostate cancer. Domain Associates Prostate Cancer Foundation Chief Executive Officer Helene Brown Nelson Peltz Ralph Finerman • Gives men and their families hope for better, longer lives. Director, Community Chairman and Secretary, Treasurer and Applications of Research Chief Executive Officer Chief Financial Officer UCLA Triarc Companies, Inc. Debbie Bohnett S. Ward (Trip) Casscells III, M.D. Lynda Resnick Chief Operating Officer Calendar John Edward Tyson Distinguished Vice Chairman Professor of Medicine and Vice Roll International Stuart Holden, M.D. President of Biotechnology Medical Director Robin Richards University of Texas HSC, Houston Chairman and CEO Craig A. Dionne, Ph.D. Events 2004 Blue for Men David Ederer Notification Technologies Executive Vice President, Chairman Research and Therapeutics Bert Roberts Ederer Investment Company October ’04–January ’05 Major men’s fashion designers Consultant Gregg S. Britt Sue Gin Senior Vice President, Pacific Life Open Club Championships have joined the PCF to launch Richard Sandler Chairman and Biopharmaceutical Partner Qualifying Tournaments Chief Executive Officer Research and Development a nationwide, yearlong Blue Maron and Sandler Flying Food Group, Inc. for Men campaign to raise Executive Vice President Scott Harvey The Reverend Rosey Grier The Milken Family Foundation December 1, 2004 awareness and funds for Senior Vice President, The Milken Family Foundation Corporate Alliances Survivor’s Celebration Breakfast Lorraine Spurge prostate cancer research. Andrew Grove Managing Director Seattle, Washington Jan Haber Chairman Post Advisory Group Vice President, Events and Intel Corporation Donor Relations Events 2005 Michael Tarnopol December 1, 2004 Stuart Holden, M.D. Vice Chairman Helen Hsieh Director, Cedars-Sinai Bear, Stearns & Co. Inc. Gourmet Games February 25–27, 2005 Vice President, Finance and Louis Warschaw Administration Robert Voss Los Angeles, California The Carl H. Lindner Prostate Cancer Center President Warschaw, Robertson, Martin Erck Pro-Am Invitational Fox Packaging Company Law Families Chair Vice President, The Mar-a-Lago Club in Prostate Cancer Jerry Weintraub Special Projects Palm Beach, Florida Cedars-Sinai Medical Center President Jerry Weintraub Productions
For more information about these events, visit www.prostatecancerfoundation.org
One in six men will get prostate cancer. The PCF provides funding for research to find the cure that will save lives. We provide hope to the men and families living with this disease. We must do more and we need your help to do it. Please return the enclosed pledge card today.
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