Finding Better Treatments and a Cure for Recurrent Prostate Cancer: Winter 2004 Progress Report • Detection, Diagnosis and Prognosis PCF-Funded Scientist Prostate Cancer Foundation of Prostate Cancer Aaron Ciechanover Releases Its First Annual Report • Local Treatment of Prostate Cancer • Androgen Deprivation Therapy Awarded Nobel Prize for Prostate Cancer to the Nation on Prostate Cancer The Prostate Cancer Foundation is pleased • Management of Bone Metastases to honor Aaron Ciechanover, M.D., winner in Patients with Prostate Cancer n addition to being the world’s leading source of philanthropic of the 2004 Nobel Prize in Chemistry and Isupport for prostate cancer research, the Prostate Cancer • Chemotherapeutic Options in a recipient of multiple research grants Patients with Prostate Cancer Foundation (PCF) is also one of the leading sources of information from the Prostate Cancer Foundation. • Emerging Therapies for Prostate Cancer about progress toward better treatments and a cure for recurrent The PCF has provided Dr. Ciechanover • Management of Side Effects in with research grants each year since 2000 prostate cancer and a leading force in accelerating that progress. Prostate Cancer Therapy to investigate the application of his research to the development of new therapies for • Nutrition and Prevention Strategies for prostate cancer. Dr. Ciechanover has On September 22, the Prostate Cancer to gain a clearer understanding of how to Prostate Cancer Foundation introduced a new publication work together to provide prostate cancer reported on these investigations at several designed to increase the base of knowledge patients with optimal care. The Report • Therapeutic Strategies for Patients with of the PCF’s annual Scientific Retreats, about prostate cancer: The Report to the also features important “calls to action” a Rising PSA: A Case-Based Approach including the 2004 Retreat held in October. Nation on Prostate Cancer. The Report for prostate cancer researchers to address Although the Report is primarily targeted The Nobel Foundation recognized is designed to increase knowledge among unanswered scientific questions and for to physicians, well-informed patients and Dr. Ciechanover’s work in illuminating physicians about leading approaches healthcare providers to focus on important caregivers may find the Report interesting the significance of the cellular machine to the treatment of prostate cancer. and valuable as well. issues related to disease management. called the proteasome, which regulates Supported by the PCF’s Pharmaceutical the destruction of unneeded cell proteins. Industry Roundtable, the Report provides Two world-renowned cancer researchers The Report is available online at www.prostatecancerfoundation.org and a comprehensive overview of the state- served as executive editors: Peter R. The proteasome is the target of the drug is being distributed in print to more than of-the-art in the diagnosis, treatment Carroll, M.D., professor and chair of the Velcade, which is approved for use in 20,000 physicians who treat patients and prevention of prostate cancer and Department of Urology at University of treating multiple myeloma and is being with prostate cancer. sets a clear research agenda for the future. California at San Francisco, and William tested for use in treating prostate cancer. G. Nelson, M.D., Ph.D., professor, The PCF has also provided crucial fund- With authors from a wide array of Following a media launch at the New Departments of Oncology, Urology, ing to support the clinical development specialties, the Report supports the concept York Academy of Sciences, a Continuing Pharmacology, Medicine and Pathology of Velcade. of a multidisciplinary approach to the Medical Education (CME)-certified live at The Johns Hopkins University. symposium was held, with more than management of prostate cancer. The PCF “The Prostate Cancer Foundation salutes 120 tristate area physicians in attendance. intends the Report to be used by all those Following an introduction by the execu- Dr. Aaron Ciechanover and congratulates An additional 300 physicians participated involved in the care of prostate cancer tive editors, the Report is comprised of him for winning the Nobel Prize in via a live webcast on Medscape.com patients—including urologists, medical nine chapters written by 22 prostate Chemistry. His discovery of the critical (the webcast will remain available at oncologists and radiation oncologists— cancer thought leaders. The chapters are: importance of the proteasome is crucial Medscape.com for one year), and in the to the development of new therapies for first week alone, more than 15,000 prostate cancer,” said Leslie D. Michelson, healthcare providers viewed the Report vice chairman and CEO of the Prostate chapters on the Medscape site. Each Cancer Foundation. “The PCF funded of the nine chapters of the Report are Dr. Ciechanover through its Israel also available as a CME activity on Initiative, which is part of our worldwide Medscape.com/prostatecancer. effort to harness the talents of the best The Report has already generated and brightest in the fight for better treat- significant media coverage from Time ments and a cure for recurrent prostate magazine, USA Today, NBC News, CBS cancer,” he added. News, the Washington Times, CNN.com, BusinessWeek Online and Health News Daily, among others. Inside This Issue The PCF gratefully acknowledges the support of Abbott Laboratories, Aventis, Novartis and Sanofi-Synthelabo, the founding members of the PCF’s From the CEO 2 Pharmaceutical Industry Roundtable, Board News 2 which supported this initiative and helped to defray the costs of producing the Report. Science Update 3 The content of the Report was developed Lifestyle 4 entirely by the Report’s authors with no Peter T. Scardino, M.D., chair of the Department of Urology and head of the prostate cancer editorial input from the members of the Recipe 5 program at Memorial Sloan-Kettering Cancer Center (left); Daniel P. Petrylak, M.D., associate Roundtable in any manner. professor of medicine at Columbia University College of Physicians & Surgeons (center); and News 6 –7 Peter R. Carroll, M.D., professor and chair, UCSF Department of Urology (right), answer questions at a media briefing regarding the PCF’s Report to the Nation on Prostate Cancer Events 7 held at the New York Academy of Sciences on September 22, 2004. Calendar 8 Leadership 8 1 www.prostatecancerfoundation.org 310.570.4700 From the CEO Publications Board News s part of our ongoing program to keep you The Prostate Cancer Foundation Earle I. Mack Named Ambassador Ainformed about our progress, we want to tell you publishes many publications each year to the Republic of Finland that highlight news and features about President George W. Bush has confirmed about some important developments in our quest to the Foundation’s support of prostate Prostate Cancer Foundation board find better treatments and a cure for recurrent prostate cancer research, programs, treatment member Earle I. Mack to be Ambassador cancer. In short, this has been one of the best periods projects, clinical trials, studies, resources Extraordinary and Plenipotentiary of the ever for scientific accomplishments, fund-raising and and successful PCF partnerships. United States of America to the Republic of Finland. Well-connected in both visibility for this cause. Here are some highlights: Nobody Knows business and political circles, Mr. Mack Few people realize that prostate cancer has been a PCF board member since is the most common non-skin cancer in Science 2003, and was a senior partner and chief America, striking more than 230,000 financial officer for the nearly century-old • Over the past few years, we have funded research intended to identify men each year. The PCF has updated its Mack Company. The firm, headquartered informative booklet entitled Nobody surrogate endpoints for prostate cancer clinical trials so that the trials can in Rochelle Park, New Jersey, invests, Knows to raise prostate cancer awareness. be conducted more rapidly, with fewer patients, less expense and clearer develops and manages income-producing results. This research has matured to the point that on June 21 and 22, commercial real estate. Mr. Mack has a long track record of success in business, the FDA convened a workshop attended by over 250 people to determine and is a leading philanthropist supporting the optimal way to proceed. the arts, education and cancer research. • We provided multiple research grants to Aaron Ciechanover, M.D., to President George W. Bush has support his investigation of the proteasome and possible applications to Report to the Nation confirmed Prostate Cancer prostate cancer. For his groundbreaking work in this area, Dr. Ciechanover The Report to the Nation on Prostate Cancer Foundation board member was awarded the 2004 Nobel Prize in Chemistry. is a comprehensive overview of the state- of-the-art in the diagnosis, treatment and Earle I. Mack to be Ambassador Fund-raising prevention of prostate cancer. Extraordinary and Plenipotentiary We set records from our June fund-raising programs centered around of the United States of America Father’s Day: to the Republic of Finland. • Safeway once again demonstrated the strength of its commitment to the community by raising close to $3.4 million in its annual point-of-purchase At the 2001 New York Dinner, the PCF honored Earle Mack along with his program in all 1,800 Safeway, Vons, Pavilions, Dominick’s, Randalls, Tom brothers, David, Bill and Fred, for their Thumb, Genuardi’s and Carrs stores. widespread philanthropy that includes, in addition to support of the Prostate • Our eighth annual Home Run Challenge in conjunction with Major Cancer Foundation, major gifts to the League Baseball generated more than $2 million as hundreds of people PCF NewsPulse Long Island Jewish Health System, whose around the country made donations. The Prostate Cancer Foundation has North Shore University Hospital was launched NewsPulse, an email newsletter ranked the number one hospital in the • Our newest program, the “Because You Love Him” eBay online auction, that educates individuals about the U.S.