fmicb-10-00127 February 27, 2019 Time: 13:2 # 1 ORIGINAL RESEARCH published: 28 February 2019 doi: 10.3389/fmicb.2019.00127 The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That Is Associated With Expression of Glypican-3 Rebecca E. Tweedell1,2, Dingyin Tao2†, Timothy Hamerly1,2†, Tanisha M. Robinson3†, Simon Larsen4, Alexander G. B. Grønning4, Alessandra M. Norris1, Jonas G. King2,5, Henry Chun Hin Law1, Jan Baumbach4,6‡, Elke S. Bergmann-Leitner3‡ and Rhoel R. Dinglasan1,2* 1 Department of Infectious Diseases and Immunology, Emerging Pathogens Institute, University of Florida, Gainesville, FL, Edited by: United States, 2 W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Celio Geraldo Freire-de-Lima, Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 3 Malaria Vaccine Universidade Federal do Rio Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States, 4 Computational BioMedicine Lab, de Janeiro, Brazil Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark, 5 Department Reviewed by: of Biochemistry, Molecular Biology, Entomology & Plant Pathology, Mississippi State University, Starkville, MS, United States, Rodrigo Andrés López-Muñoz, 6 Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Southern University of Chile, Chile Munich, Germany Miguel Prudêncio, University of Lisbon, Portugal In vitro studies of liver stage (LS) development of the human malaria parasite *Correspondence: Rhoel R. Dinglasan Plasmodium falciparum are technically challenging; therefore, fundamental questions
[email protected]fl.edu about hepatocyte receptors for invasion that can be targeted to prevent infection remain †These authors have contributed unanswered.