Biological Inspired Joints for Innovative Articulation Concepts
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Somatosensory Systems
Somatosensory Systems Sue Keirstead, Ph.D. Assistant Professor Dept. of Integrative Biology and Physiology Stem Cell Institute E-mail: [email protected] Tel: 612 626 2290 Class 9: Somatosensory System (p. 292-306) 1. Describe the 3 main types of somatic sensations: 1. tactile: light touch, deep pressure, vibration, cold, hot, etc., 2. pain, 3. Proprioception. 2. List the types of sensory receptors that are found in the skin (Figure 9.11) and explain what determines the optimum type of stimulus that will activate each. 3. Describe the two different modality-specific ascending somatosensory pathways and note which modalities are carried in each (Figure 9.10 and 9.13). 4. Describe how it is possible for us to differentiate between stimuli of different modalities in the same body part (i.e. fingertip). Consider this at the level of 1) the sensory receptors and 2) the neurons onto which they synapse in the ascending sensory systems. 5. Explain how one might determine the location of a spinal cord injury based on the modality of sensation that is lost and the region of the body (both the side of the body and body part) where sensation is lost (Figure 9.18). 6. Describe how incoming sensory inputs from primary sensory axons can be modified at the level of the spinal cord and relate this to the mechanism of action of some common pain medications (Figure 9-18). 7. Describe the homunculus and explain the significance of the size of the region of the somatosensory cortex devoted to a particular body part. Cerebral cortex Interneuron Thalamus Interneuron 4 Integration of sensory Stimulus input in the CNS 1 Stimulation Sensory Axon of sensory of sensory receptor neuron receptor Graded potential Action potentials 2 Transduction 3 Generation of of the stimulus action potentials Copyright © 2016 by John Wiley & Sons, Inc. -
Chapter 9: the Muscular System Module 9.1 Overview of Skeletal Muscles
CHAPTER 9: THE MUSCULAR SYSTEM MODULE 9.1 OVERVIEW OF SKELETAL MUSCLES STRUCTURE OF A SKELETAL MUSCLE • Skeletal muscles are not made of muscle cells alone • Skeletal muscle contains blood vessels that supply muscle cells with oxygen and glucose, and remove wastes, and nerves that coordinate muscle contraction • Skeletal muscle also contains connective tissue (next slide) STRUCTURE OF A SKELETAL MUSCLE . Each individual muscle cell (fiber) is surrounded by thin connective tissue called endomysium (Figure 9.1) . Several (between 10 and 100) muscle cells are bundled together into a fascicle by the connective tissue perimysium . All fascicles that make up a muscle are, in turn, enclosed in an outer fibrous connective tissue wrapping (epimysium) STRUCTURE OF A SKELETAL MUSCLE . Interconnected connective tissues taper down and connect to tendons or other connective tissues; attach muscle to bone or other structure to be moved . Example of Structure-Function Core Principle; makes sure muscle pulls as a unit even if some muscle cells are not pulling with same strength as others STRUCTURE OF A SKELETAL MUSCLE • Motor unit – describes motor neuron-muscle cell interaction; example of Cell-Cell Communication Core Principle . Consists of a single motor neuron and all muscle cells it connects to . Some motor units have only a few muscle cells, whereas others have many . Fewer muscle cells in a motor unit = more precise movements of that muscle when it contracts STRUCTURE OF A SKELETAL MUSCLE Shape, size, placement, and arrangement of fibers in a skeletal muscle contribute to function of that muscle; form follows function (Figures 9.2, 9.3; Table 9.1) STRUCTURE OF A SKELETAL MUSCLE Fascicles and Muscle Shapes • Fascicles – bundles of muscle cells whose specific arrangement affects both appearance and function of whole skeletal muscle • Following are different arrangements in which fascicles are found in human body (Figure 9.2) 1 STRUCTURE OF A SKELETAL MUSCLE Fascicles and Muscle Shapes (continued): . -
Mathematical Model of Pennate Muscle (LIF043-15)
CORE Metadata, citation and similar papers at core.ac.uk Provided by Lodz University of Technology Repository Mathematical model of pennate muscle (LIF043-15) Wiktoria Wojnicz, Bartłomiej Zagrodny, Michał Ludwicki, Jan Awrejcewicz, Edmund Wittbrodt Abstract: The purpose of this study is to create a new mathematical model of pennate striated skeletal muscle. This new model describes behaviour of isolated flat pennate muscle in two dimensions (2D) by taking into account that rheological properties of muscle fibres depend on their planar arrangement. A new mathematical model is implemented in two types: 1) numerical model of unipennate muscle (unipennate model); 2) numerical model of bipennate muscle (bipennate model). Applying similar boundary conditions and similar load, proposed numerical models had been tested. Obtained results were compared with results of numerical researches by applying a Hill-Zajac muscle model (this is a Hill type muscle model, in which the angle of pennation is taken into consideration) and a fusiform muscle model (a muscle is treated as a structure composed of serially linked different mechanical properties parts). 1. Introduction The human movement system consists of striated skeletal muscles that have different architectures. Among these muscles are fusiform muscles and pennate muscles (unipennate muscles, bipennate muscles and multipennate muscles) [7]. The fusiform muscle fibers run generally parallel to the muscle axis (it is line connecting the origin tendon and the insertion tendon). The unipennate muscle fibers run parallel to each other but at the pennation angle to the muscle axis [6]. The bipennate muscle consists of two unipennate muscles that run in two distinct directions (i.e. -
Tissue Engineered Myelination and the Stretch Reflex Arc Sensory Circuit: Defined Medium Ormulation,F Interface Design and Microfabrication
University of Central Florida STARS Electronic Theses and Dissertations, 2004-2019 2009 Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium ormulation,F Interface Design And Microfabrication John Rumsey University of Central Florida Part of the Biology Commons Find similar works at: https://stars.library.ucf.edu/etd University of Central Florida Libraries http://library.ucf.edu This Doctoral Dissertation (Open Access) is brought to you for free and open access by STARS. It has been accepted for inclusion in Electronic Theses and Dissertations, 2004-2019 by an authorized administrator of STARS. For more information, please contact [email protected]. STARS Citation Rumsey, John, "Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium Formulation, Interface Design And Microfabrication" (2009). Electronic Theses and Dissertations, 2004-2019. 3826. https://stars.library.ucf.edu/etd/3826 TISSUE ENGINEERED MYELINATION AND THE STRETCH REFLEX ARC SENSORY CIRCUIT: DEFINED MEDIUM FORMULATION, INTERFACE DESIGN AND MICROFABRICATION by JOHN WAYNE RUMSEY B.S. University of Florida, 2001 M.S. University of Central Florida, 2004 A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Burnett School of Biomedical Sciences in the College of Medicine at the University of Central Florida Orlando, Florida Fall Term 2009 Major Professor: James J. Hickman ABSTRACT The overall focus of this research project was to develop an in vitro tissue- engineered system that accurately reproduced the physiology of the sensory elements of the stretch reflex arc as well as engineer the myelination of neurons in the systems. In order to achieve this goal we hypothesized that myelinating culture systems, intrafusal muscle fibers and the sensory circuit of the stretch reflex arc could be bioengineered using serum-free medium formulations, growth substrate interface design and microfabrication technology. -
BRS Physiology 3Rd Edition
Board Review Series • Reflects USMLE changes • Approximately 350 USMLE-type questions with explanations • Numerous illustrations, diagrams, and tables • Easy-to-follow outline covering all USMLE-tested topics • A comprehensive examination V Ah, LIPPINCOTT -"*" WILLIAMS &WILKIN; mum IEEE mows IF 'IMP IMMO MINK I I. Key Physiology Topics for USMLE Step I Cell Physiology Transport mechanisms Ionic basis for action potential Excitation-contraction coupling in skeletal, cardiac, and smooth muscle Neuromuscular transmission Autonomic Physiology Cholinergic receptors Adrenergic receptors Effects of autonomic nervous system on organ system function Cardiovascular Physiology Events of cardiac cycle Pressure, flow, resistance relationships Frank-Starling law of the heart Ventricular pressure-volume loops Ionic basis for cardiac action potentials Starling forces in capillaries Regulation of arterial pressure (baroreceptors and renin-angiotensin II-aldosterone system) Cardiovascular and pulmonary responses to exercise Cardiovascular responses to hemorrhage Cardiovascular responses to changes in posture Respiratory Physiology Lung and chest-wall compliance curves Breathing cycle Hemoglobin-02 dissociation curve Causes of hypoxemia and hypoxia vq, P02, and P00 2 in upright lung V/Q defects Peripheral and central chemoreceptors in control of breathing Responses to high altitude Renal and Acid-Base Physiology Fluid shifts between body fluid compartments Starling forces across glomerular capillaries Transporters in various segments of nephron (Na Cl-, -
Muscle-Tendon Length and Force Affect Human Tibialis Anterior Central
Muscle-tendon length and force affect human tibialis PNAS PLUS anterior central aponeurosis stiffness in vivo Brent James Raiteria,b,1, Andrew Graham Cresswella, and Glen Anthony Lichtwarka aCentre for Sensorimotor Performance, School of Human Movement and Nutrition Sciences, The University of Queensland, St. Lucia, QLD 4072, Brisbane, Australia; and bHuman Movement Science, Faculty of Sport Science, Ruhr-University Bochum, 44801 Bochum, Nordrhein-Westfalen, Germany Edited by Silvia Salinas Blemker, University of Virginia, Charlottesville, VA, and accepted by Editorial Board Member C. O. Lovejoy February 21, 2018 (received for review July 20, 2017) The factors that drive variable aponeurosis behaviors in active versus considering stress–strain relationships of tendinous tissues estimated passive muscle may alter the longitudinal stiffness of the aponeuro- from muscle fiber/fascicle length changes (7, 10, 24, 25). However, sis during contraction, which may change the fascicle strains for a there is a growing body of literature to suggest that the SEE stiffness given muscle force. However, it remains unknown whether these is dependent on contractile conditions (13, 15, 26–28), as well as factors can drive variable aponeurosis behaviors across different suggestions that the aponeurosis cannot be a simple in-series spring muscle-tendon unit (MTU) lengths and influence the subsequent (29). The potential variable nature of aponeurosis elastic function is fascicle strains during contraction. Here, we used ultrasound and likely to impact our understanding of how this tissue contributes to elastography techniques to examine in vivo muscle fascicle behavior energy savings and/or power amplification during animal or human and central aponeurosis deformations of human tibialis anterior (TA) locomotion (30), as well as our understanding of the strains expe- during force-matched voluntary isometric dorsiflexion contractions rienced by muscles and connective tissues during such contractions at three MTU lengths. -
Cortex Brainstem Spinal Cord Thalamus Cerebellum Basal Ganglia
Harvard-MIT Division of Health Sciences and Technology HST.131: Introduction to Neuroscience Course Director: Dr. David Corey Motor Systems I 1 Emad Eskandar, MD Motor Systems I - Muscles & Spinal Cord Introduction Normal motor function requires the coordination of multiple inter-elated areas of the CNS. Understanding the contributions of these areas to generating movements and the disturbances that arise from their pathology are important challenges for the clinician and the scientist. Despite the importance of diseases that cause disorders of movement, the precise function of many of these areas is not completely clear. The main constituents of the motor system are the cortex, basal ganglia, cerebellum, brainstem, and spinal cord. Cortex Basal Ganglia Cerebellum Thalamus Brainstem Spinal Cord In very broad terms, cortical motor areas initiate voluntary movements. The cortex projects to the spinal cord directly, through the corticospinal tract - also known as the pyramidal tract, or indirectly through relay areas in the brain stem. The cortical output is modified by two parallel but separate re entrant side loops. One loop involves the basal ganglia while the other loop involves the cerebellum. The final outputs for the entire system are the alpha motor neurons of the spinal cord, also called the Lower Motor Neurons. Cortex: Planning and initiation of voluntary movements and integration of inputs from other brain areas. Basal Ganglia: Enforcement of desired movements and suppression of undesired movements. Cerebellum: Timing and precision of fine movements, adjusting ongoing movements, motor learning of skilled tasks Brain Stem: Control of balance and posture, coordination of head, neck and eye movements, motor outflow of cranial nerves Spinal Cord: Spontaneous reflexes, rhythmic movements, motor outflow to body. -
Variable Gearing in Pennate Muscles
Variable gearing in pennate muscles Emanuel Azizi*, Elizabeth L. Brainerd, and Thomas J. Roberts Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912 Edited by Ewald R. Weibel, University of Bern, Bern, Switzerland, and approved December 3, 2007 (received for review September 27, 2007) Muscle fiber architecture, i.e., the physical arrangement of fibers within a muscle, is an important determinant of a muscle’s me- chanical function. In pennate muscles, fibers are oriented at an angle to the muscle’s line of action and rotate as they shorten, becoming more oblique such that the fraction of force directed along the muscle’s line of action decreases throughout a contrac- tion. Fiber rotation decreases a muscle’s output force but increases output velocity by allowing the muscle to function at a higher gear ratio (muscle velocity/fiber velocity). The magnitude of fiber rota- tion, and therefore gear ratio, depends on how the muscle changes shape in the dimensions orthogonal to the muscle’s line of action. Here, we show that gear ratio is not fixed for a given muscle but decreases significantly with the force of contraction (P < 0.0001). We find that dynamic muscle-shape changes promote fiber rota- tion at low forces and resist fiber rotation at high forces. As a result, gearing varies automatically with the load, to favor velocity output during low-load contractions and force output for contractions against high loads. Therefore, muscle-shape changes act as an automatic transmission system allowing a pennate muscle to shift Fig. 1. A 17th century geometric examination of muscle architecture (5). -
The Human Nervous System S Tructure and Function
The Human Nervous System S tructure and Function S ixth Ed ition The Human Nervous System Structure and Function S ixth Edition Charles R. Noback, PhD Professor Emeritus Department of Anatomy and Cell Biology College of Physicians and Surgeons Columbia University, New York, NY Norman L. Strominger, PhD Professor Center for Neuropharmacology and Neuroscience Department of Surgery (Otolaryngology) The Albany Medical College Adjunct Professor, Division of Biomedical Science University at Albany Institute for Health and the Environment Albany, NY Robert J. Demarest Director Emeritus Department of Medical Illustration College of Physicians and Surgeons Columbia University, New York, NY David A. Ruggiero, MA, MPhil, PhD Professor Departments of Psychiatry and Anatomy and Cell Biology Columbia University College of Physicians and Surgeons New York, NY © 2005 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. All papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. This publication is printed on acid-free paper. h ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. Production Editor: Tracy Catanese Cover design by Patricia F. Cleary Cover Illustration: The cover illustration, by Robert J. Demarest, highlights synapses, synaptic activity, and synaptic-derived proteins, which are critical elements in enabling the nervous system to perform its role. -
Effect of Strength Training on Muscle Architecture (Review) Javid Mirzayev Mediland Hospital, Republic of Azerbaijan Tula State University, Russian Federation
60 SPORTO MOKSLAS / 2017, Nr. 1(87), ISSN 1392-1401 / eISSN 2424-3949 Sporto mokslas / Sport Science 2017, Nr. 1(87), p. 60–64 / No. 1(87), pp. 60–64, 2017 DOI: http://dx.doi.org/10.15823/sm.2017.9 Effect of strength training on muscle architecture (review) Javid Mirzayev Mediland hospital, Republic of Azerbaijan Tula State University, Russian Federation Summary Muscle architecture is among the most important factors that determine the function of muscles. Muscle architecture is the “organizer” of muscle fibres in muscle strength generating relative line and includes several important aspects: 1) normalized fibre length, 2) pennation angle, and 3) physiological cross-sectional area. Architectural changes in muscles immediately respond to resistance training, but it is not entirely dependent on muscle contraction mode. To the date, we very poorly understand architectural parameters for each muscle; thus, further studies are needed to explore the architecture of individual muscles and further to expand our understanding of this important organizer of muscle fibres. The purpose of the article is to examine the relationship between strength training and muscle structures. Method chosen: analysis of scientific literature. Results and conclusions. In general, contemporary scientific research confirms in the 80-ies identified circumstantial evidence in favour of muscle architecture changes with the help of strength training. Hypertrophy of the muscle increases the angles of pennate muscles. The more muscle hypertrophy evolves, the less specific voltage occurs. Increased muscle volume in the eccentric training is closely related to increasing length of the beams, but pennation angle is not changed. The level of tension is responsible for the change in maximal voluntary contraction. -
Skeletal Muscle Tissue and Muscle Organization
Chapter 9 The Muscular System Skeletal Muscle Tissue and Muscle Organization Lecture Presentation by Steven Bassett Southeast Community College © 2015 Pearson Education, Inc. Introduction • Humans rely on muscles for: • Many of our physiological processes • Virtually all our dynamic interactions with the environment • Skeletal muscles consist of: • Elongated cells called fibers (muscle fibers) • These fibers contract along their longitudinal axis © 2015 Pearson Education, Inc. Introduction • There are three types of muscle tissue • Skeletal muscle • Pulls on skeletal bones • Voluntary contraction • Cardiac muscle • Pushes blood through arteries and veins • Rhythmic contractions • Smooth muscle • Pushes fluids and solids along the digestive tract, for example • Involuntary contraction © 2015 Pearson Education, Inc. Introduction • Muscle tissues share four basic properties • Excitability • The ability to respond to stimuli • Contractility • The ability to shorten and exert a pull or tension • Extensibility • The ability to continue to contract over a range of resting lengths • Elasticity • The ability to rebound toward its original length © 2015 Pearson Education, Inc. Functions of Skeletal Muscles • Skeletal muscles perform the following functions: • Produce skeletal movement • Pull on tendons to move the bones • Maintain posture and body position • Stabilize the joints to aid in posture • Support soft tissue • Support the weight of the visceral organs © 2015 Pearson Education, Inc. Functions of Skeletal Muscles • Skeletal muscles perform -
Biomechanics of Skeletal Muscle 4
Oatis_CH04_045-068.qxd 4/18/07 2:21 PM Page 45 CHAPTER Biomechanics of Skeletal Muscle 4 CHAPTER CONTENTS STRUCTURE OF SKELETAL MUSCLE . .46 Structure of an Individual Muscle Fiber . .46 The Connective Tissue System within the Muscle Belly . .48 FACTORS THAT INFLUENCE A MUSCLE’S ABILITY TO PRODUCE A MOTION . .48 Effect of Fiber Length on Joint Excursion . .48 Effect of Muscle Moment Arms on Joint Excursion . .50 Joint Excursion as a Function of Both Fiber Length and the Anatomical Moment Arm of a Muscle . .51 FACTORS THAT INFLUENCE A MUSCLE’S STRENGTH . .52 Muscle Size and Its Effect on Force Production . .52 Relationship between Force Production and Instantaneous Muscle Length (Stretch) . .53 Relationship between a Muscle’s Moment Arm and Its Force Production . .56 Relationship between Force Production and Contraction Velocity . .58 Relationship between Force Production and Level of Recruitment of Motor Units within the Muscle . .60 Relationship between Force Production and Fiber Type . .61 ADAPTATION OF MUSCLE TO ALTERED FUNCTION . .62 Adaptation of Muscle to Prolonged Length Changes . .62 Adaptations of Muscle to Sustained Changes in Activity Level . .63 SUMMARY . .64 keletal muscle is a fascinating biological tissue able to transform chemical energy to mechanical energy. The focus of this chapter is on the mechanical behavior of skeletal muscle as it contributes to function and dysfunc- S tion of the musculoskeletal system. Although a basic understanding of the energy transformation from chemi- cal to mechanical energy is essential to a full understanding of the behavior of muscle, it is beyond the scope of this book. The reader is urged to consult other sources for a discussion of the chemical and physiological interactions that produce and affect a muscle contraction [41,52,86].