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Genetic Analysis of Over One Million People Identifies 535 Novel Loci for Blood Pressure

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Genetic Analysis of Over One Million People Identifies 535 Novel Loci for Blood Pressure bioRxiv preprint doi: https://doi.org/10.1101/198234; this version posted October 11, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Genetic analysis of over one million people identifies 535 novel loci for blood pressure. Short title: blood pressure GWAS in one million people Evangelos Evangelou1,2*, Helen R Warren3,4*, David Mosen-Ansorena1*, Borbala Mifsud3*, Raha Pazoki1*, He Gao1,5*, Georgios Ntritsos2*, Niki Dimou2*, Claudia P Cabrera3,4, Ibrahim Karaman1, Fu Liang Ng3, Marina Evangelou1,6, Katarzyna Witkowska3, Evan Tzanis3, Jacklyn N Hellwege7 , Ayush Giri7, Digna R Velez-Edwards8, Yan V Sun9,10,Kelly Cho11,12, J.Michael Gaziano11,12, Peter WF Wilson13, Philip S Tsao14, Csaba P Kovesdy15, Tonu Esko16,17, Reedik Mägi16, Lili Milani16, Peter Almgren18, Thibaud Boutin19, Stéphanie Debette20,21, Jun Ding22, Franco Giulianini23, Elizabeth G Holliday24, Anne U Jackson25, Ruifang Li-Gao26, Wei-Yu Lin27, Jian'an Luan28, Massimo Mangino29,30, Christopher Oldmeadow24, Bram Prins31, Yong Qian22, Muralidharan Sargurupremraj21, Nabi Shah32,33, Praveen Surendran27, Sébastien Thériault34,35, Niek Verweij17,36,37, Sara M Willems28, Jing- Hua Zhao28, Philippe Amouyel38, John Connell39, Renée de Mutsert26, Alex SF Doney33, Martin Farrall40,41, Cristina Menni29, Andrew D Morris42, Raymond Noordam43, Guillaume Paré34, Neil R Poulter44, Denis C Shields45, Alice Stanton46, Simon Thom44, Gonçalo Abecasis47, Najaf Amin48, Dan E Arking49, Kristin L Ayers50, Caterina M Barbieri51,52, Chiara Batini53, Joshua C Bis54, Tineka Blake53, Murielle Bochud55, Michael Boehnke25, Eric Boerwinkle56, Dorret I Boomsma57, Erwin P Bottinger58, Peter S Braund59,60, Marco Brumat61, Archie Campbell62,63, Harry Campbell64, Aravinda Chakravarti49, John C Chambers1,5,65-67, Ganesh Chauhan68,69, Marina Ciullo70,71, Massimiliano Cocca52, Francis Collins72, Heather J Cordell73, Gail Davies74,75, Martin H de Borst76, Eco J de Geus57, Ian J Deary74,75, Joris Deelen77, Fabiola M Del Greco 78, Cumhur Yusuf Demirkale79, Marcus Dörr80,81, Georg B Ehret49,82, Roberto Elosua83, Stefan Enroth84, A.Mesut Erzurumluoglu53, Teresa Ferreira85, Mattias Frånberg86-88, Oscar H Franco89, Ilaria Gandin61, Paolo Gasparini61,90, Vilmantas Giedraitis91, Christian Gieger92-94, Giorgia Girotto61,95, Anuj Goel40,41, Alan J Gow74,96, Vilmundur Gudnason97,98, Xiuqing Guo99, Ulf Gyllensten84, Anders Hamsten86,87, Tamara B Harris100, Sarah E Harris62,74, Catharina A Hartman101, Aki S Havulinna102, Andrew A Hicks78, Edith Hofer103,104, Albert Hofman89,105, Jouke-Jan Hottenga57, Jennifer E Huffman106, Shih-Jen Hwang107,108, Erik Ingelsson109,110, Alan James111,112, Rick Jansen113, Marjo-Riitta Jarvelin5,114-116, Roby Joehanes117,118, Åsa Johansson84, Andrew D Johnson118,119, Peter K Joshi64, Pekka Jousilahti102, J Wouter Jukema120, Antti Jula102, Mika Kähönen121,122, Sekar Kathiresan17,36,123, Bernard D Keavney124,125, Kay-Tee Khaw126, Paul Knekt102, Joanne Knight127, Ivana Kolcic128, Jaspal S Kooner5,67,129,130, Seppo Koskinen102, Kati Kristiansson102, Zoltan Kutalik55,131, Maris Laan132, Marty Larson118, Lenore J Launer100, Benjamin C Lehne1, Terho Lehtimäki133,134, Daniel Levy118,119, David CM Liewald74,75, Li Lin82, Lars Lind135, Cecilia M Lindgren40,136, YongMei Liu137, Ruth JF Loos28,138,139, Lorna M Lopez74,140,141, Yingchang Lu58, Leo-Pekka Lyytikäinen133,134, Anubha Mahajan40, Chrysovalanto Mamasoula142, Jaume Marrugat83, Jonathan Marten106, Yuri Milaneschi143, Anna Morgan61, Andrew P Morris40,144, Alanna C Morrison145, Peter J Munson79, Mike A Nalls146,147, Priyanka Nandakumar49, Christopher P Nelson59,60, Christopher Newton-Cheh136,148,149, Teemu Niiranen102, Ilja M Nolte150, Teresa Nutile70, Albertine J Oldehinkel151, Ben A Oostra48, Paul F O'Reilly152, Elin Org16, Sandosh Padmanabhan63,153, Walter Palmas154, Aarno Palotie155, Alison Pattie75, Brenda WJH Penninx143, Markus Perola102,155,156, Annette Peters93, Ozren Polasek128, Peter P Pramstaller78,157,158, Nguyen Quang Tri79, Olli T Raitakari159,160, Meixia Ren161,162, Rainer 1 bioRxiv preprint doi: https://doi.org/10.1101/198234; this version posted October 11, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Rettig163, Kenneth Rice164, Paul M Ridker23,165, Janina S Ried93, Harriëtte Riese151, Samuli Ripatti155,166, Antonietta Robino52, Lynda M Rose23, Jerome I Rotter99, Igor Rudan167, Daniela Ruggiero70, Yasaman Saba168, Cinzia F Sala51, Veikko Salomaa102, Nilesh J Samani59,60, Antti-Pekka Sarin155, Reinhold Schmidt103, Helena Schmidt168, Nick Shrine53, David Siscovick169, Albert V Smith97,98, Harold Snieder150, Siim Sõber132, Rossella Sorice70, John M Starr74,170, David J Stott171, David P Strachan172, Rona J Strawbridge86,87, Johan Sundström135, Morris A Swertz173, Kent D Taylor99, Alexander Teumer81,174, Martin D Tobin53, Daniela Toniolo51, Michela Traglia51, Stella Trompet120,175, Jaakko Tuomilehto176- 179, Christophe Tzourio68,69,180, André G Uitterlinden89,181, Ahmad Vaez150,182, Peter J van der Most150, Cornelia M van Duijn48, Anne-Claire Vergnaud1, Germaine C Verwoert89, Veronique Vitart106, Uwe Völker81,183, Peter Vollenweider184, Dragana Vuckovic61,185, Hugh Watkins40,41, Sarah H Wild64, Gonneke Willemsen57, James F Wilson19,64, Alan F Wright106, Jie Yao99 , Tatijana Zemunik186, Weihua Zhang1,129, John R Attia24, Adam S Butterworth27,187, Dan Chasman23,165, David Conen188,189, Francesco Cucca190, John Danesh27,187, Caroline Hayward19, Joanna MM Howson27, Markku Laakso191, Edward G Lakatta192, Claudia Langenberg28, Olle Melander18, Dennis O Mook-Kanamori26,193, Patricia B Munroe3, Colin NA Palmer33, Lorenz Risch194-196, Robert A Scott28, Rodney J Scott24, Peter Sever130, Tim D Spector29, Pim van der Harst197, Nicholas J Wareham28, Eleftheria Zeggini31, Morris J Brown3,4, Andres Metspalu16, Adriana M Hung198, Christopher J O’Donnell199, Todd L Edwards7 on behalf of the Million Veteran Program, Bruce M. Psaty200,201, Ioanna Tzoulaki1,2,5*, Michael R Barnes3,4*, Louise V Wain53*, Paul Elliott1,5*‡, Mark J Caulfield3,4* ‡ * Equal contribution ‡ Corresponding authors 1. Department of Epidemiology and Biostatistics, Imperial College London, London, UK. 2. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. 3. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. 4. National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK. 5. MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK. 6. Department of Mathematics, Imperial College London, UK 7. Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN. 8. Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN. 9. Department of Epidemiology and Biomedical Informatics, Emory University Rollins School of Public Health, Atlanta GA, USA. 10. Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA. 11. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA. 2 bioRxiv preprint doi: https://doi.org/10.1101/198234; this version posted October 11, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 12. Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, Department of Medicine, Harvard Medical School, Boston, MA. 13. Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, 30233. 14. VA Palo Alto Health Care System; Division of Cardiovascular Medicine, Stanford University School of Medicine. 15. Nephrology Section, Memphis VA Medical Center, Memphis TN. 16. Estonian Genome Center, University of Tartu, Tartu, Estonia. 17. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA. 18. Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden. 19. MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK 20. Department of Neurology, Bordeaux University Hospital, F-33000 Bordeaux, France. 21. University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, France. 22. Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD 21224, USA. 23. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. 24. Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia. 25. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA. 26. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 27. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge,
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