Proposal for the Inclusion of Anti-Emetic Medications (For Children) in the Who Model List of Essential Medicines
Second Meeting of the Subcommittee of the Expert Committee on the Selection and Use of Essential Medicines Geneva, 29 September to 3 October 2008 PROPOSAL FOR THE INCLUSION OF ANTI-EMETIC MEDICATIONS (FOR CHILDREN) IN THE WHO MODEL LIST OF ESSENTIAL MEDICINES REPORT Marc Bevan, Elizabeth Seil, Robin Bell and Jane Robertson Discipline of Clinical Pharmacology School of Medicine and Public Health Faculty of Health University of Newcastle Level 5, Clinical Sciences Building, NM2 Calvary Mater Hospital Edith Street, Waratah, 2298 New South Wales AUSTRALIA Tel +61-02-49211726 Fax + 61-02-49602088 WHO EML – anti-emetics – June 2008 1. Summary statement of the proposal Anti-emetic medications (anti-histamines, dopamine antagonists and serotonin 5-HT3 antagonists) are proposed for inclusion in the World Health Organization (WHO) Model List of Essential Medicines for the management of acute gastroenteritis in children. 2. Name of focal point in WHO submitting or supporting the application 3. Name of the organisation preparing the application Discipline of Clinical Pharmacology, School of Medicine and Public Health, Faculty of Health, University of Newcastle, Level 5, Clinical Sciences Building, NM2, Calvary Mater Hospital, Edith Street, Waratah, 2298, New South Wales, Australia. 4. International Nonpropriety Name (INN, generic name) of the medicine The proposal reviews relevant data regarding four anti-emetic medications; metoclopramide and domperidone (dopamine agonists), promethazine (anti- histamine) and ondansetron (serotonin 5-HT3 antagonist). 5. Formulation considered for inclusion The formulations of metoclopramide, domperidone, promethazine and ondansetron considered for inclusion are shown in Table 1. Table 1: Formulations of ant-emetic medications considered for inclusion Formulation Comment Metoclopramide Injection or oral - Injection, tablet and oral liquid formulations are preparation (tablet, currently listed on WHO EML for children.
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