DOCSLIB.ORG

Human Brucellosis

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Human Brucellosis MEDICAL PRACTICE J Am Board Fam Pract: first published as on 1 September 2002. Downloaded from Human Brucellosis John M. Sauret, MD, and Natalia Vilissova, MD Background: Human brucellosis has a serious medical impact worldwide, and its eradication poses major difficulties. Although human brucellosis is relatively rare in the United States (approximately 100 cases per year), there is concern that this disease is largely underdiagnosed and underreported. Addi- tionally, immigrants from endemic areas are arriving to this country, and Brucella species are consid- ered to be biologic agents for terrorism. Human brucellosis affects all age-groups, and family physi- cians are not well versed in recognizing and treating this potentially life-threatening condition. Methods: A literature review from 1975 to 2001 was performed using the key words “human brucel- losis,” “zoonosis,” and “bioterrorism.” Results and Conclusions: Appropriate antimicrobial therapy and duration of treatment of human brucellosis will reduce morbidity, prevent complications, and diminish relapses. Because of the nonspe- cific symptoms and rarity of human brucellosis in the United States, family physicians must acquire a detailed dietary and occupational history to diagnose the disease promptly. Family physicians must as- sume a responsible role in reporting this disease, as well as be aware of persons at high-risk for this disease and the potential sources of infection. (J Am Board Fam Pract 2002;15:401–6.) Human brucellosis is a potentially life-threatening Methods multisystem disease. Rarely reported in the United A literature review was performed using the key States, human brucellosis is a zoonotic disease of words “human brucellosis,” “zoonosis,” and “bio- bacterial origin. The first case was reported in the terrorism,” dating from 1975 to 2001. A case report on human brucellosis is described. United States in 1898 by Musser and Sailer, and http://www.jabfm.org/ reported cases reached a maximum of 6,321 in 1947.1 Since that time, there has been a steady Case Report decline. The Centers for Disease Control and Pre- An 8-year-old girl complained of a 2-week history vention (CDC) reported approximately 100 cases of a severe sore throat, fever, abdominal pain, an- each year during the past 10 years, with most cases orexia, and a 5-pound weight loss. Eight days ear- in the southwest region.2 The decline in disease lier she had immigrated with her parents from on 2 October 2021 by guest. Protected copyright. incidence is mainly due to compulsory pasteuriza- Syria, where she recently had been given a 4-week tion of milk and to the control of the disease in course of trimethoprim-sulfamethoxazole for an 3 dairy cattle. Worldwide, this disease has a major apparent food-borne illness. She completed the an- presence in the Middle East, southern Europe, and tibiotic approximately 2 weeks before the onset of South America (ie, Brazil, Columbia). Studies have the latest symptoms. shown that in the United States human brucellosis The patient’s medical history was remarkable is underdiagnosed and underreported. The report- only for rheumatic fever. She had no history of ing rate in some states, ie, California, has been as surgery and no known drug allergies. Her birth was low as 10%.1 without incident, and her immunizations, which included the BCG vaccine, were up to date. She had been born in Iraq and moved with her parents and three siblings to Syria, where she lived on a Submitted, revised, 24 October 2001. farm. A detailed dietary history showed she con- From the Department of Family Medicine (JMS, NV), School of Medicine and Biomedical Sciences, SUNY at sumed unpasteurized goat’s milk. Buffalo. Address reprint requests to John M. Sauret, MD, At admission to the hospital the patient was Department of Family Medicine, State University of New York at Buffalo, Office of Research and Development, 462 febrile (102.0°F [38.9°C]), tachycardic (108 beats Grider St, Buffalo, NY 14215. per minute), slightly tachypneic (24/min), and nor- Human Brucellosis 401 Table 1. Admission Laboratory Results. presumptive diagnosis of human brucellosis until it Laboratory Test Value was confirmed. Throughout her hospital course the J Am Board Fam Pract: first published as on 1 September 2002. Downloaded from patient’s pancytopenia worsened. This condition Prothrombin time 21.2 sec was probably drug induced and not due to the Partial thromboplastin time 53.8sec infection. To avoid further bone marrow suppres- Fibrinogen 785 mg/dL (7.85 g/L) sion caused by trimethoprim-sulfamethoxazole, the Bicarbonate 21 mEq/L (mmol/L) antibiotic regimen was changed to the combination Chloride 99 mEq/L (mmol/L) of rifampicin with doxycycline and gentamicin. Af- Blood urea nitrogen 12 mg/dL (4.28mmol/L) ter consultation with a hematologist and infectious Creatinine 0.5 mg/dL (44.2 ␮mol/L) Glucose 89 mg/dL (4.94 mmol/L) disease specialist, it was recommended that she be Amylase 50 U/L given intravenous rifampin and gentamicin for 5 Total protein 5,600 mg/dL (56 g/L) days and then complete a total of 45 days of oral Serum aspartate 257 U/L rifampin and a 45-day course of oral doxycycline. aminotransferase Her age of 8years allowed for the use of doxycy- Serum alanine aminotransferase 94 U/L cline without dental concerns. Alkaline phosphatase 173 U/L By the ninth day of admission, repeated blood cultures showed that her bacteremia had resolved. Her fever subsided, and findings from a second motensive (90/48mm Hg.). She appeared acutely echocardiogram were normal. She was released ill but nontoxic, and her oral mucosa was dry. Her from the hospital to complete 45 days of oral ri- tympanic membranes were normal, her oropharynx fampicin and doxycycline and was symptom-free was erythematous, and her tonsils were swollen with no signs of relapse at 3-month and 6-month (2ϩ) but without exudate. Her neck had full range follow-up examinations. of motion, and there was diffuse cervical adenopa- thy. Her abdomen was not distended, but it was diffusely tender, chiefly in the right upper quad- Discussion rant, where the liver was palpated 5 cm below the This patient had a case of acute human brucellosis costal margin, and in the left upper quadrant, caused by B melitensis infection. There are six Bru- http://www.jabfm.org/ where the spleen was palpated 4 cm below the cella species, four of which are known to infect costal margin. Findings of neurologic and derma- humans: B melitensis, B abortus, B suis, and B canis. B tologic examinations were normal. The lungs were abortus is found principally in cattle; B melitensis,in clear to auscultation, and no murmurs, rubs, or goats and sheep; B suis, in swine; and B canis, in gallops were heard during her heart examination. kennel-raised dogs. B canis is the least common Laboratory findings at admission showed the cause of human brucellosis, and most infections of on 2 October 2021 by guest. Protected copyright. following values: leukopenia (white cell count 2.1 ϫ B canis have been acquired in the laboratory.4 109/L), anemia (hemoglobin 9.9 g/L), thrombocy- Human brucellosis is common in many parts of topenia (platelets 118 ϫ 109/L), and hypoalbumin- the world but not in the United States. The true emia (albumin 25 g/L). Other pertinent results are incidence is unknown, although in the United displayed in Table 1. States the CDC reports fewer than 0.05 cases per An echocardiogram showed a small pericardial 100,000 population, with most being reported from effusion but no valvular disease. A bone marrow Texas, California, and Illinois. During the past 10 biopsy showed evidence of noncaseating granulo- years, approximately 100 cases per year have been mas consistent with brucellosis. Positive blood cul- reported in the United States.2 Human brucellosis tures showing gram-negative bacilli consistent with is widespread in the Middle East. Epidemiologic Brucella melitensis infection confirmed the diagno- studies in such areas as southern Saudi Arabia have sis. Serum agglutination test for B melitensis was shown that 19.2% of that population had serologic 1/160, and the erythrocyte sedimentation rate was evidence of exposure and 2.3% had active disease.5 6 mm/h. A Monospot test was negative, and throat Several other bacterial diseases are transmitted by and urine cultures were normal. farm animals to humans (Table 2). Initially the patient was given intravenous tri- Brucellosis is a multisystem disease with a broad methoprim-sulfamethoxazole and rifampicin for spectrum of nonspecific symptoms that generally 402 JABFP September–October 2002 Vol. 15 No. 5 Table 2. Bacterial Diseases Transmitted by Farm Animals. Common Farm Animal J Am Board Fam Pract: first published as on 1 September 2002. Downloaded from Disease and Organism Source Means of Spread Brucellosis (Brucella species) Cattle, goats, sheep, swine Direct contact with birth products, ingestion of milk, inhalation of aerosols Campylobacteriosis (Campylobacter jejuni) Poultry Ingestion of contaminated food, direct contact Hemolytic-uremic syndrome (Escherichia Cattle Ingestion of contaminated food or water coli 0157:H7) Leptospirosis (Leptospira species) Livestock Contact with urine, particularly in contaminated water Salmonellosis (Salmonella species) Poultry Ingestion of contaminated food, direct contact Tetanus (Clostridium tetani) Any animal, usually indirect, Wound infection, contaminated bite via soil Yersiniosis (Yersinia enterocolitica) Swine Ingestion of contaminated food or water, rarely direct contact Anthrax (Bacillus anthracis) Goats, sheep, cattle, swine, Contact with infected animals or their contaminated horse, buffalo, deer products Adapted from 2000 The Red Book: Report on the Committee on Infectious Diseases. 25th edition. Elk Grove Village, Ill: American Academy of Pediatrics, 2000:773–4. occur within 2 weeks (but sometimes up to 3 lapses occur within 3 to 6 months of stopping months) after inoculation.
Load more

Recommended publications
  • Compendium of Veterinary Standard Precautions for Zoonotic Disease Prevention in Veterinary Personnel
    Compendium of Veterinary Standard Precautions for Zoonotic Disease Prevention in Veterinary Personnel National Association of State Public Health Veterinarians Veterinary Infection Control Committee 2010 Preface.............................................................................................................................................................. 1405 I. INTRODUCTION................................................................................................................................... 1405 A. OBJECTIVES...................................................................................................................................... 1405 B. BACKGROUND................................................................................................................................. 1405 C. CONSIDERATIONS.......................................................................................................................... 1405 II. ZOONOTIC DISEASE TRANSMISSION................................................................................................ 1406 A. SOURCE ............................................................................................................................................ 1406 B. HOST SUSCEPTIBILITY.................................................................................................................... 1406 C. ROUTES OF TRANSMISSION........................................................................................................... 1406 1. CONTACT TRANSMISSION.........................................................................................................
    [Show full text]
  • Herd Health Protocols for Dromedary Camels (Camelus Dromedarius) at Mpala Ranch and Research Centre, Laikipia County, Kenya
    Herd Health Protocols for Dromedary Camels (Camelus dromedarius) at Mpala Ranch and Research Centre, Laikipia County, Kenya September 23rd, 2012 Andrew Springer Browne, MVB Veterinary Public Health Program University of Missouri – Columbia, USA Sharon Deem, DVM, PhD, DACZM Institute for Conservation Medicine Saint Louis Zoo, St. Louis, MO, USA This guide was made to solidify husbandry and record protocols as well as give feasible advice for common health problems in camels at the Mpala Ranch and Research Centre. For thorough reviews of camel diseases and health, see “A Field Manual of Camel Diseases” by Kohler-­­Rollefson and “Medicine and Surgery of Camelids” by Fowler. Acknowledgments Many thanks to Margaret Kinnaird and Mike Littlewood for their patience and support during our visit. Thank you to Laura Budd and Sina Mahs for their incredible help and time dedicated to the project. Finally, a special thanks to S. Moso, Eputh, Abduraman, Adow, Abdulai, Ekomoel, and Ewoi for working and living with the camels every day. Asante sana. -­­ Springer and Sharon ii Table of Contents Page Key Management Goals 1 Record Keeping 2 Electronic and Paper Records 3 Entering Data into Excel Database 4 Excel Database Legend 5 Husbandry 6 Calf Care 7 Maternal Rejection 8 Dam Care 9 Branding and Identification 10 Weight Estimates/Body Condition Scoring 11 Milking Schedule and Boma Rotation 12 Veterinary Care 13 Preventive Veterinary Health Care 14 Diagnostics 15 Abortion 16 Skin Wounds 17 Abscess Treatment 18 Mastitis 19 Eye Problems 20 Diseases of Special
    [Show full text]
  • Genital Brucella Suis Biovar 2 Infection of Wild Boar (Sus Scrofa) Hunted in Tuscany (Italy)
    microorganisms Article Genital Brucella suis Biovar 2 Infection of Wild Boar (Sus scrofa) Hunted in Tuscany (Italy) Giovanni Cilia * , Filippo Fratini , Barbara Turchi, Marta Angelini, Domenico Cerri and Fabrizio Bertelloni Department of Veterinary Science, University of Pisa, Viale delle Piagge 2, 56124 Pisa, Italy; fi[email protected] (F.F.); [email protected] (B.T.); [email protected] (M.A.); [email protected] (D.C.); [email protected] (F.B.) * Correspondence: [email protected] Abstract: Brucellosis is a zoonosis caused by different Brucella species. Wild boar (Sus scrofa) could be infected by some species and represents an important reservoir, especially for B. suis biovar 2. This study aimed to investigate the prevalence of Brucella spp. by serological and molecular assays in wild boar hunted in Tuscany (Italy) during two hunting seasons. From 287 animals, sera, lymph nodes, livers, spleens, and reproductive system organs were collected. Within sera, 16 (5.74%) were positive to both rose bengal test (RBT) and complement fixation test (CFT), with titres ranging from 1:4 to 1:16 (corresponding to 20 and 80 ICFTU/mL, respectively). Brucella spp. DNA was detected in four lymph nodes (1.40%), five epididymides (1.74%), and one fetus pool (2.22%). All positive PCR samples belonged to Brucella suis biovar 2. The results of this investigation confirmed that wild boar represents a host for B. suis biovar. 2 and plays an important role in the epidemiology of brucellosis in central Italy. Additionally, epididymis localization confirms the possible venereal transmission. Citation: Cilia, G.; Fratini, F.; Turchi, B.; Angelini, M.; Cerri, D.; Bertelloni, Keywords: Brucella suis biovar 2; wild boar; surveillance; epidemiology; reproductive system F.
    [Show full text]
  • Brucellosis in the Kakheti Region of The
    DISSERTATION A SYSTEMIC REVIEW OF BRUCELLOSIS IN THE KAKHETI REGION OF THE COUNTRY OF GEORGIA: AN EVALUATION OF THE DISEASE ECOLOGY, RISK FACTORS AND SUGGESTIONS FOR DISEASE CONTROL Submitted by Karyn Alicia Havas Department of Clinical Sciences In partial fulfillment of the requirements For the Degree of Doctor of Philosophy Colorado State University Fort Collins, Colorado Fall 2011 Doctoral Committee: Advisor: Mo D. Salman Ashley E. Hill Robert J. Callan Shana C. Gillette Ann L. Magennis Copyright by Karyn A. Havas 2011 All rights reserved ABSTRACT A SYSTEMIC REVIEW OF BRUCELLOSIS IN THE KAKHETI REGION OF THE COUNTRY OF GEORGIA: AN EVALUATION OF THE DISEASE ECOLOGY, RISK FACTORS AND SUGGESTIONS FOR DISEASE CONTROL Human brucellosis is a neglected disease of poverty often found in highly agrarian, livestock dependent societies (World Health Organization, 2006). It is a purely zoonotic disease in that animals infect humans but there is not human-to-human transmission (Corbel, 2006). The highest human incidence of brucellosis in the country of Georgia is in the eastern region of Kakheti (Navdarashvili et al., 2005), which is also home to the majority of the country’s sheep and a significant portion of the country’s cattle population (Kvinikadze et al., 2009). In humans, brucellosis is acquired from animals either through direct contact with infected and shedding animals or their afterbirth or via consumption of contaminated dairy products made from the raw milk of a shedding animal. In Georgia, B. melitensis is the predominant species cultured from ill humans and has been cultured from sheep as well (Malania et al., 2009; Onashvili et al., 2009).
    [Show full text]
  • Integrated Mrna-Seq and Mirna-Seq Analysis of Goat fibroblasts Response to Brucella Melitensis Strain M5-90
    Integrated mRNA-seq and miRNA-seq analysis of goat fibroblasts response to Brucella Melitensis strain M5-90 Baobao Li*, Si Chen*, Chengqiang Wang, Qiaoling Chen, Churiga Man, Qi An, Zhenxing Zhang, Zhiyong Liu, Li Du and Fengyang Wang Hainan Key Lab of Tropical Animal Reproduction, Breeding and Epidemic Disease Research, Animal Genetic Engineering Key Lab of Haikou, College of Animal Science and Technology, Hainan University, Hainan Key Lab of Tropical Animal Reproduction, Haikou, Hainan, China * These authors contributed equally to this work. ABSTRACT Brucellosis is a globally zoonotic bacterial disease of humans and various animals including goats, sheep, and cattle. Brucella melitensis M5-90, a live attenuated vaccine strain, has been widely used to prevent brucellosis in goats and sheep. However, the molecular mechanisms governing protective immunity response in non-professional phagocytes infected with B. melitensis M5-90 have not been fully investigated, especially in goats. In our research, goat fibroblasts were used as in vitro models to determine these mechanisms by transcriptome analysis. After incubating with B. melitensis M5-90 3 h, the infected goat fibroblasts were collected at 0 h, 4 h, 24 h, 48 h and 72 h for RNA-seq. The results indicated that there were totally 11,819 differentially expressed genes (DEGs) and 777 differentially expressed (DE) miRNAs found in experiment groups compared with the control groups (|log2 (Foldchange)|≥1, FDR<0.05). GO and KEGG enrichment analyses revealed that down-regulated genes were involved in the riboflavin metabolism and positive regulation of IL-8 secretion pathway. The up-regulated genes were mainly involved in adaptive immunity, including TNF signaling pathway, MAPK signaling pathway and JAK/STAT pathway.
    [Show full text]
  • A Novel Evidence of Immunological and Molecular Detection of Brucella Species in Camels
    Journal of Pharmaceutical Research International 32(45): 78-87, 2020; Article no.JPRI.64484 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) A Novel Evidence of Immunological and Molecular Detection of Brucella Species in Camels Kavitha Manivannan1, Malathi Ramasamy2* and Hanaa Ahmed3** 1Department of Genetics, Tharb Camel Hospital, Qatar. 2Department of Biotechnology, Government Arts and Science College, Kurumbalur, Perambalur, 621107, Tamilnadu, India. 3Animal Health Research Institute, Egypt. Authors’ contributions This work was carried out in collaboration between all authors. Author KM designed the study, managed the analyses, performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Authors MR and HA designed and supervised the study, wrote the protocol, interpreted the data, and managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2020/v32i4531095 Editor(s): (1) Dr. Begum Rokeya, Bangladesh University of Health Sciences, Bangladesh. Reviewers: (1) Abdul Basit, University of Okara, Pakistan. (2) Hari Mohan Saxena, Guru Angad Dev Veterinary and Animal Sciences University, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/64484 Received 10 November 2020 Original Research Article Accepted 17 January 2021 Published 02 February 2021 ABSTRACT Objectives: Brucellosis is a zoonosis with severe complications for both humans and animals. In this work, we intended to examine the Brucella infection in dromedary camels in Qatar by using different analysis. Materials and Methods: A total of 203 samples of dromedary camels were randomly collected from the nearby farms in Qatar. Real-time PCR for the genus specific Brucella cell surface salt extractable bcsp31 kDa protein gene were performed on DNA extracted from camel samples.
    [Show full text]
  • Brucella Melitensis with Immune Response Upon Secondary
    Humoral Immunity and CD4+ Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis This information is current as of September 25, 2021. Marie-Alice Vitry, Delphine Hanot Mambres, Carl De Trez, Shizuo Akira, Bernhard Ryffel, Jean-Jacques Letesson and Eric Muraille J Immunol 2014; 192:3740-3752; Prepublished online 19 March 2014; Downloaded from doi: 10.4049/jimmunol.1302561 http://www.jimmunol.org/content/192/8/3740 http://www.jimmunol.org/ Supplementary http://www.jimmunol.org/content/suppl/2014/03/19/jimmunol.130256 Material 1.DCSupplemental References This article cites 93 articles, 41 of which you can access for free at: http://www.jimmunol.org/content/192/8/3740.full#ref-list-1 Why The JI? Submit online. by guest on September 25, 2021 • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2014 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Humoral Immunity and CD4+ Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis Marie-Alice Vitry,* Delphine Hanot Mambres,* Carl De Trez,† Shizuo Akira,‡ Bernhard Ryffel,x,{ Jean-Jacques Letesson,*,1 and Eric Muraille‖,1 Brucella spp are intracellular bacteria that cause brucellosis, one of the most common zoonoses in the world.
    [Show full text]
  • A Small Non-Coding RNA Facilitates Brucella Melitensis Intracellular Survival by Regulating the Expression of Virulence Factor T
    International Journal of Medical Microbiology 309 (2019) 225–231 Contents lists available at ScienceDirect International Journal of Medical Microbiology journal homepage: www.elsevier.com/locate/ijmm A small non-coding RNA facilitates Brucella melitensis intracellular survival by regulating the expression of virulence factor T Yufei Wanga,1, Yuehua Keb,1, Cuijuan Duana,1, Xueping Maa, Qinfang Haoa, Lijie Songa, ⁎⁎⁎ Xiaojin Guoa, Tao Suna, Wei Zhanga, Jing Zhanga, Yiwen Zhaoa, Zhijun Zhongc, , ⁎⁎ ⁎ Xiaoli Yanga, , Zeliang Chenb,d, a Department of laboratory medicine, The Third Medical Center, General Hospital of the Chinese People’s Liberation Army, Beijing 100039, China b Department of Infectious Disease Control, Center of Disease Control and Prevention, Beijing 100071, China c Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan 611130, China d Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Key Laboratory of Zoonosis of Liaoning Province, College of Aninal Science and Veterinary Medicine, Shenyang Agricultural University, Liaoning, 110866, China ARTICLE INFO ABSTRACT Keywords: Brucella species are the causative agents of brucellosis, a worldwide zoonotic disease that affects a broad range of Brucella mammals and causes great economic losses. Small regulatory RNAs (sRNAs) are post-transcriptional regulatory sRNA molecules that participate in the stress adaptation and pathogenesis of Brucella. In this study, we characterized Intracellular survival the role of a novel sRNA, BSR1141, in the intracellular survival and virulence of Brucella melitensis. The results Stress response show that BSR1141 was highly induced during host infections and under in vitro stress situations that simulated Virulence the conditions encountered within host phagocytes.
    [Show full text]
  • Caprine Brucellosis: a Historically Neglected Disease with Significant Impact on Public Health
    REVIEW Caprine brucellosis: A historically neglected disease with significant impact on public health Carlos A. Rossetti1*, Angela M. Arenas-Gamboa2, EstefanõÂa Maurizio1 1 Instituto de PatobiologõÂa, CICVyA-CNIA, INTA. NicolaÂs Repetto y de Los Reseros s/n, Hurlingham, Buenos Aires, Argentina, 2 Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America * [email protected] a1111111111 a1111111111 a1111111111 Abstract a1111111111 a1111111111 Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacil- lus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak off- spring are the characteristic clinical signs of the disease that is associated with an extensive negative impact in a flock's productivity. B. melitensis is also the most virulent Brucella spe- cies for humans, responsible for a severely debilitating and disabling illness that results in OPEN ACCESS high morbidity with intermittent fever, chills, sweats, weakness, myalgia, abortion, osteoarti- Citation: Rossetti CA, Arenas-Gamboa AM, cular complications, endocarditis, depression, anorexia, and low mortality. Historical obser- Maurizio E (2017) Caprine brucellosis: A historically neglected disease with significant vations indicate that goats have been the hosts of B. melitensis for centuries; but around impact on public health. PLoS Negl Trop Dis 11(8): 1905, the Greek physician Themistokles Zammit
    [Show full text]
  • Brucellosis Reporting and Investigation Guideline
    Brucellosis Signs and • Acute or insidious irregular fevers, sweats, chills, headache, anorexia, arthralgia Symptoms • Can be hepatic or splenic abscesses, or osteoarticular or genitourinary symptoms • Chronic infections may cause arthritis, osteomyelitis, endocarditis, or neurological complications Incubation Typically 2-4 weeks (range 5 days-5 months) Case Clinical criteria: fever and one or more of the following: night sweats, fatigue, classification anorexia, myalgia, weight loss, headache, arthralgia, arthritis/spondylitis, meningitis, or focal organ involvement (heart, testes, liver, spleen) Confirmed: Clinically consistent with Probable: Clinically consistent with epi link positive culture or 4-fold rise in titers to human or animal case or titer by taken at least 2 weeks apart agglutination ≥ 160 or PCR positive Differential Includes multiple causes of fever including bacterial endocarditis, viral hepatitis, diagnosis leptospirosis, lymphoma, malaria, rickettsioses, tuberculosis, toxoplasmosis, tularemia, typhoid, vasculitis Treatment Appropriate antibiotic combination (generally dual therapy) for weeks. Rare deaths from endocarditis. Duration Acute illness days to week, chronic infection months to years Exposure Skin or mucosal membrane exposure to infected birth tissues or fluids from cattle, goats, sheep, elk, deer; consuming raw milk from infected animal; inhalational exposure in a laboratory or slaughterhouse; potential agent of bioterrorism; rare transmission sexually or through breast milk Laboratory Local Health Jurisdiction
    [Show full text]
  • Brucellosis Annual Report 2018
    Brucellosis Annual Report 2018 Brucellosis Brucellosis is a Class A Disease. It must be reported to the state within 24 hours by calling the number listed on the website. Brucellosis is a zoonotic infection of domesticated and wild animals, caused by bacteria of the genus Brucella. Humans become infected by ingestion of food products of animal origin (such as undercooked meat or unpasteurized milk or dairy products), direct contact with infected animals, or inhalation of infectious aerosols. Brucella abortus (cattle), B.melitensis (sheep and goats), B.suis (pigs), and B.canis (dogs), are the most common species. The most common etiology in the U.S. is B.melitensis. Marine Brucella (B.ceti and B.pinnipedialis) may also pose a risk to humans who interact with marine animals; people should avoid contact with stranded or dead marine mammals. Infection may cause a range of symptoms, including fever, sweats, malaise, anorexia, headache, joint and muscle pain, and fatigue. Some symptoms may last for prolonged periods of time including recurrent fevers, arthritis, swelling of the testicle and scrotum area, swelling of the heart, swelling of the liver and/or spleen, neurologic symptoms, chronic fatigue, and depression. Treatment consists of antibiotics, but recovery may take a few weeks to several months. Bovine brucellosis caused by B. abortus, is a bacterial infection transmitted through oral exposure to uterine discharges from infected cows at time of calving or abortion. This previously common disease has been eliminated from the state through the cooperation of the cattle industry and state-federal animal health officials. On November 1, 2000, Louisiana was declared free of brucellosis in cattle.
    [Show full text]
  • Brucellosis History Summary by Russell W
    Brucellosis History Summary by Russell W. Currier DVM, MPH Dr. Currier is a DVM, MPH, and Diplomate of the American College for Veterinary Preventive Medicine, who retired from a career as an Iowa State Public Health Veterinarian. Dr. Currier currently presides as President of the American Veterinary Medical History Society. Brucellosis is a sexually transmissible as well as contact-transmitted infection of livestock that can have adverse effects on the fetus and newborn. It occasionally transmits to humans in roles of animal handlers, raw milk consumers, and packing plant workers. In humans, the disease is infectious with long term chronic but distressing febrile episodes rarely fatal with modern clinical management; treatment remains in the domain of infectious disease physicians and should not be attempted by family doctors. The causative organism is Brucella melitensis [from sheep/goats], Brucella bovis [from cattle], Brucella suis [from swine] and Brucella canis [from dogs]. Historically, the disease was recognized in the Mediterranean region, particularly in goats and sheep, dating back to antiquity. Brucellosis-type illnesses were recognized by Hippocrates in his Epidemics writings; the Apostle Paul is considered to have been infected following his being shipwrecked on the Island of Malta and suffered from a recurrent illness or “thorn in my flesh” afterward. Britain maintained a military base on this island during the 18th and 19th centuries. During this period, several British physicians provided vivid descriptions of illness in garrisoned troops and physician David Bruce was dispatched to investigate; he isolated the causative organism from four fatal cases in 1887 and named it Micrococcus melitensis.
    [Show full text]