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PROGRAMME Organized by the Dynamical Systems Interdisciplinary Network, University of Copenhagen Funded by The UCPH Excellence Programme for Interdisciplinary Research and The Center for Models of Life, Niels Bohr Institute Last update: August 29, 2014 Contents Venue Information and Maps ii Programme v Abstracts vii List of Participants xviii Organizing Committee Erik Andreas Martens Susanne Ditlevsen Rune Berg Olga Sosnovtseva Niels-Henrik Holstein-Rathlou University of Copenhagen The Faculty of Science The Faculty of Health and Medical Sciences http://dsin.ku.dk/calendar/workshop_sep14/ i Venue Information and Maps Venue: University of Copenhagen The Niels Bohr Institute, Auditorium A Niels Bohr Institutet Blegdamsvej 17, 2100 Copenhagen Ø Welcome Reception and Poster Session The Welcoming reception on Monday at 17.30 and the coee breaks will take place in the Lille Frokoststue (Small Lunch Room) near the NBI lunch room. Poster boards and pins are provided; poster sizes should be size A1 or A2 (but not A0) to save the limited space. Lunch: University of Copenhagen Canteen of Niels Bohr Institute Blegdamsvej 17 2100 Copenhagen Ø Conference Dinner Tuesday, September 2, 19:00 Restaurant Søren K Søren Kierkegaards Plads 1, 1221 København K map location Internet The entire Niels Bohr Institute is covered by the Eduroam wireless network.The eduroam wireless network can be accessed with your username and password from your home institution. Alterna- tively, you can connect to the network Conference using the password Bohr2013. You can nd guidance regarding network security and printers at the website www.nbi.dk/computation. How to get to the Institute All talks will take place in Auditorium A at the Niels Bohr Institute (NBI) on Blegdamsvej 17. All information you need for how to reach the Niels Bohr Institute from hotels/metro sta- tions/railway stations can be found here. There you will also nd a detailed map of the area and further relevant information, e.g. tickets for public transportation. ii Maps of the Venue A detailed map with all hotel, restaurant, bar and conference venue locations is available here. The Niels Bohr Institute NBI Canteen NBI Canteen,Coffee CoffPosteree break, session Poster session Auditorium A Auditorium A Blegdamsvej 17 Blegdamsvej 17 Niels Bohr Institute Hotel Nora CabInn Nørreport St. Scandinavia Metro/Train to/from Kastrup airport Researcher Hotel Figure 1: Top Map: Auditorium A (lecture hall) and nearby lunch restaurant. Bottom Map: Auditorium A (lecture hall), Hotel Nora, CabInn Scandinavia and Researcher Hotel. Nørreport train and metro station. Where to eat and drink There are plenty of choice on where to eat and drink in Copenhagen, both near the Venue of the conference and in the city center. A detailed list and map can be found here. A good location is Sankt Hans Torv (10 minutes walking from the venue of the conference) and nearby, where you nd several nice bars, cafe, restaurants and pubs. Other options (all listed here) are the following: Where to eat Restaurant (Reservation is recommended) • Halifax Burgers: one of the best burger place in Copenhagen. Burger + side dishes: 130 DKK. • Zafran Restaurant: Persian food; main courses: 90-120 DKK; you can bring your own bottle of wine. • LéLé Street Kitchen: Vietnamese food; 50-100 DKK. • Det Lille Apotek: Oldest restaurant in Copenhagen, Danish food. Main courses: 70-150 DKK (lunch), 170-240 DKK (dinner). • Søren K Restaurarant: Danish food; main course: 175 DKK (lunch), 225 DKK (dinner) Where to drink Café where you can also eat burgers/salads • The Laudromat Cafe , Elmegade 15 • Cafe 22 , Sortedam Dossering 21 • Restaurant Barcelona , Fælledvej 21 If you are thirsty, then it is time for a beer at: • Mikkeller: Microbrewery. Mikkeller bar in Viktoriagade 8 B-C. Mikkeller & friends in Stefansgade. • Brew Pub: Microbrewery in the city center. • Ølbaren: Plenty of beers from all over the world. Programme Monday, September 1 08:30-09:00 Registration 09:00-09:10 Welcome and practical informations 09:10-09:50 Albert Goldbeter: CDK oscillations drive the mammalian cell cycle 09:50-10:30 Alexander Aulehla: Self-organization of cellular genetic oscillators during embryo devel- opment 10:30-11:00 Coee Break 11:00-11:40 Ala Trusina: Dynamic complexity of NF-kB regulatory network 11:40-12:20 Hanspeter Herzel: The circadian clock a system of coupled oscillators 12:20-13:00 Umberto Picchini : Approximate Bayesian Computation (ABC) for diusions observed with measurement error and large sample sizes: an application to protein folding data 13:00-14:30 Lunch at the NBI Cafe 14:30-15:10 Peter Ashwin: Indistinguishable oscillators and chimeras 15:10-15:50 Michael Rosenblum: Reconstructing eective phase connectivity of oscillator networks from observations 15:50-16:30 Coee Break 16:30-17:30 Plenary Discussion 17:30-19:00 Welcome reception + Poster session v Tuesday, September 2 09:00-09:10 Announcements 09:10-09:50 Mogens H. Jensen: : Oscillators and Arnold tongues in cell dynamics 09:50-10:30 Rainer Dahlhaus: Phase synchronization and co-integration: bridging two theories 10:30-11:00 Coee Break 11:00-11:40 Christian Kuehn : Oscillations in multiple time scale dynamics: Autocatalysis, Koper, Olsen, and beyond 11:40-12:20 Diego Pazo: Exact ring-rate description for networks of spiking neurons 12:20-13:00 Carlo Laing: Twisted states in phase oscillator arrays 13:00-14:30 Lunch at the NBI Cafe 14:30-15:10 Marc Timme: Information routing in complex networks: remote control and hub-induced signal propagation 15:10-15:50 Arkady Pikovsky: Collective dynamics of oscillator populations: nonlinear coupling and multifrequency ensembles 15:50-16:30 Coee Break 16:30-17:30 Plenary Discussion 19:00-open! Conference Dinner at Restaurant Søren K Wednesday, September 3 09:00-09:40 Jordi Garcia-Ojalvo: Dynamics of bacterial stress response 09:40-10:20 Eleni Katifori: Structural self-assembly in locally Adaptive Networks 10:20-11:00 Natalya Janson: Networks of stochastic neuron-like systems 10:30-11:00 Coee Break 11:00-11:40 Johnny Ottesen: Ultradian and circadian oscillations in the neuroendocrine HPA-axis and its relation to depression 11:40-12:20 Michael Zaks: Dynamics in regular networks: hierarchy of couplings 12:20-13:00 Peter Ditlevsen: The glacial cycles, a puzzle of the Climate System 13:00-14:30 Lunch at the NBI Cafe Abstracts Self-organization of cellular genetic oscillators during embryo development Aulehla, Alexander (speaker) EMBL Heidelberg, Germany, [email protected] In our group, we are focusing on the temporal aspect of embryonic development and thus on the role of embryonic oscillators. In mouse embryos, several signaling pathways oscillate in their activity (period 2hours) during mesoderm patterning and these oscillations are linked to the formation of pre-vertebrae, or somites. Most strikingly, oscillations occur phase-shifted between neighbouring cells, producing spatio-temporal wave patterns that traverse the embryo. In this talk, I will discuss a novel in vitro assay for segmentation and real-time quantications of oscillatory activities, revealing the potential of genetic oscillators to self-organize and generate coherent spatio-temporal wave patterns from a randomized starting condition. I will present recent ndings addressing underlying working principles. Indistinguishable oscillators and chimeras Ashwin, Peter (speaker) University of Exeter, UK, [email protected] Burylko, Oleksandr National Academy of Sciences, Kiev, Ukraine Keywords: Coupled oscillator; Symmetry; Chimera state. This talk will look at an approach to understanding some emergent dynamics in coupled oscil- lator systems composed of identical and indistinguishable oscillators in terms of modules. In par- ticular we propose a checkable denition for a chimera state and give some basic results on systems that can/cannot have chimera states in their dynamics using this denition. These include chimera states for systems of at least four oscillators with two coupling strengths and Hansel-Mato-Meunier type coupling. We also explore the relationship between this and a modular network structure. Phase synchronization and cointegration: bridging two theories Dahlhaus, Rainer (speaker) Heidelberg University, Germany, [email protected] Jan C. Neddermeyer DZ Bank, Frankfurt, Germany Keywords: phase synchronization, cointegration, state space model, statistical tests vii The theory of cointegration has been the leading theory in econometrics with powerful appli- cations to macroeconomics during the last decades. On the other hand phase synchronization for oscillators has been a major research topic in physics with many applications in dierent areas of science. In particular in neuroscience the understanding of phase synchronization is of impor- tance since phase synchronization is regarded as essential for functional coupling of dierent brain regions. In an abstract sense both theories describe the dynamic uctuation around some equilib- rium. In this talk we point out that, after some mathematical transformation, there exists a close connection between both subjects. As a consequence several techniques on statistical inference for cointegrated systems can immediately be applied for statistical inference on phase synchronization based on empirical data. This includes tests for phase synchronization, tests for unidirectional coupling and the identication of the equilibrium from data including phase shifts. We give an example where a chaotic Rössler-Lorenz system is identied with the methods from cointegration. Cointegration may also be used to investigate phase synchronization in complex networks. References Dahlhaus, R. and Neddermeyer, J.C. (2012). On the relationship between the theory of cointegra- tion and the theory of phase synchronization. arXiv:1201.0651 The glacial cycles, a puzzle of the climate system Ditlevsen, Peter (speaker) University of Copenhagen, Denmark, [email protected] The dynamics of the climate system is governed by a complex network of interactions between the atmosphere, the oceans, the land and ice-masses and the biosphere. In the latest geological epoch the climate has changed regularly between iceages and warm periods like our present climate.