A Characteristic Ganglioside Antibody Pattern in the CSF of Patients With
Journal ofNeurology, Neurosurgery, and Psychiatry 1993;56:361-364 361 A characteristic ganglioside antibody pattern in J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.56.4.361 on 1 April 1993. Downloaded from the CSF of patients with amyotrophic lateral sclerosis Andreas Stevens, Michael Weller, Horst Wietholter Abstract Materials and methods Paired cerebrospinal fluid and serum Thirty five patients with amyotrophic lateral samples of patients with amyotrophic sclerosis, 16 men and 19 women, mean age lateral sclerosis (n = 35) revealed no con- 53-5 (2 4) years, range 25-79 years at diag- sistent abnormalities of CSF cell count, nosis, without a family history of the illness, CSF albumin, CSF IgG, CSF IgM, IgG were included in this study. The diagnosis or IgM index, or oligoclonal immuno- was clinical and based on the presence of globulin band formation in the CSF. both upper and lower motor neuron symp- Determination of IgG and IgM CSF and toms and signs. Eight patients had prominent serum antibodies to gangliosides GM1, bulbar signs, 31 had definite spasticity. For GM2, GM3, AGMI, GDla, GDlb, and inclusion in this study, the onset of symptoms GTlb showed a characteristic pattern had to be insidious and not started before the which allowed the differentiation of age of 20. The clinical course had to be amyotrophic lateral sclerosis from con- progressive. Specific attention was given to trols and from patients with other neuro- alternative diagnoses of cervical spondylosis, logical disorders including multiple neoplastic lesions of cervical spinal cord sclerosis. Specifically, patients with the and brain stem, polymyositis, peripheral disease had elevated CSF IgM antibodies neuropathy, progressive muscle atrophy, to all gangliosides except AGMI.
[Show full text]