Curriculum Vitae Miriam Cnop
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Symposium ”Diabetes - a Threat to Mankind”
Symposium ”Diabetes - a Threat to Mankind” 7-8 June, 2013 in Helsinki, Finland The Finnish Diabetic Nephropathy Study Folkhälsan Institute of Genetics, Folkhälsan Research Center Biomedicum Helsinki 1, room C318 Haartmaninkatu 8 FI- 00290, Helsinki www.finndiane.fi Local Organizing Committee Per-Henrik Groop [email protected] tel. +358 9 191 25459 Carol Forsblom [email protected] tel. +358 40 5559556 Asta Mustonen [email protected] tel. +358 44 7883743 Maikki Parkkonen [email protected] tel. +358 9 19125387 Dear Participants, It is my great pleasure and honor to welcome you all to the “Diabetes – A Threat to Mankind” symposium held in Helsinki on June 7-8, 2013. This symposium will include presentations by a roster of award winning keynote speakers exploring both type 1 and type 2 diabetes and cover- ing topics ranging from disease pathogenesis to diabetic complications. This symposium was made possible by an unrestricted educational grant from the Wilhelm and Else Stockmann Foundation. Established in 1953 with the goal of promoting research that aims to prevent or ease the suffering caused by common complex diseases, the Wilhelm and Else Stockmann Foundation has played a major role in supporting dia- betes research in Finland. This symposium will serve to highlight both the 60th anniversary of the Foundation as well as the 15th Anniversary of the Finnish Diabetic Nephropathy Study. My sincere thanks go to all invited speakers and chairmen who, de- spite their busy schedules all agreed to come to Helsinki to share their knowledge and expertise with us. I am also indebted to all of you who accepted the invitation to take part in this event. -
EASD2020 Finalprogramme.Pdf
56TH ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES Content Page EASD . 4 Morgagni Prize . 10 General Information . 12 EASD Community Plaza . 15 Programme at a Glance . 20 EASD e-Learning . 28 European Diabetes Forum (EUDF) . 29 EFSD Mentorship Programme . 30 Tuesday, 22 September . 32 Claude Bernard Lecture . 32 Poster Event A . 41 Poster Event B . 42 Camillo Golgi Lecture . 50 Albert Renold Lecture . 52 Wednesday, 23 September . 54 Poster Event C . 64 Poster Event D . 65 Diabetes Prize for Excellence Lecture . 72 Thursday, 24 September . 77 Rising Star Symposium . 80 Poster Event E . 90 Poster Event F . 91 Minkowski Lecture . 98 Friday, 25 September . 102 Posters . 119 Index of Presenting Authors . 230 Index of Symposium Speakers . 242 European Foundation for the Study of Diabetes (EFSD) . 244 Symposia on the occasion of the 56th EASD Annual Meeting . 248 Industry Symposia and Meet the Expert Sessions on the occasion of the 56th EASD Annual Meeting (organised by INTERPLAN) . 263 57th EASD Annual Meeting . 310 DEAR MEMBERS AND GUESTS, It is my great honour and pleasure to welcome you to the 56th Annual Meeting of the European Association for the Study of Diabetes, which will take place – due to the severe global impact of the COVID-19 pandemic – as an innovative Virtual Meeting from 21 to 25 September 2020. EASD We have developed a virtual experience using the latest technology to connect the global diabetes community, share ground-breaking diabetes science and research, and to provide educational opportunities that -
1065.Full-Text.Pdf
Diabetes Care Volume 40, August 2017 1065 Frans K. Gorus,1,2 Eric V. Balti,1,2 Twenty-Year Progression Rate to Anissa Messaaoui,3 Simke Demeester,1,2 Annelien Van Dalem,1,2 Olivier Costa,1,2 Clinical Onset According to Harry Dorchy,3 Chantal Mathieu,4 fi Luc Van Gaal,5 Bart Keymeulen,1,6 Autoantibody Pro le, Age, and Daniel¨ G. Pipeleers,1 and Ilse Weets,1,2 for HLA-DQ Genotype in a Registry- the Belgian Diabetes Registry* Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes Diabetes Care 2017;40:1065–1072 | https://doi.org/10.2337/dc16-2228 OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb+)infirst-degree relatives of patients with type 1 diabetes. PATHOPHYSIOLOGY/COMPLICATIONS 1Diabetes Research Center, Vrije Universiteit RESEARCH DESIGN AND METHODS Brussel, Brussels, Belgium Persistently islet autoAb+ siblings and offspring (n =462)under40yearsofagewere 2Department of Clinical Chemistry, Universitair followed by the Belgian Diabetes Registry. AutoAbs against insulin (IAA), GAD Ziekenhuis Brussel, Brussels, Belgium 3Department of Diabetology, Hopitalˆ Universitaire (GADA), IA-2 antigen (IA-2A), and zinc transporter 8 (ZnT8A) were determined by des Enfants Reine Fabiola, Brussels, Belgium radiobinding assay. 4Department of Endocrinology, Universitair Ziekenhuis Leuven, Leuven, Belgium RESULTS 5Department of Endocrinology, Diabetology and The 20-year progression rate of multiple-autoAb+ relatives (n = 194) was higher than Metabolism, Universitair Ziekenhuis Antwerpen, + Antwerp, Belgium that for single-autoAb participants (n = 268) (88% vs. 54%; P < 0.001). -
KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
98 4S SUPPLEMENT TO kidney international kidney INTERNATIONAL volume 98volume issue 4S October 2020 KDIGO 2020 Clinical Practice Guideline for pages S1–S116 Diabetes Management in Chronic Kidney Disease VOLUME 98 | ISSUE 4S | OCTOBER 2020 www.kidney-international.org KKINT_v98_i4_sS_COVER.inddINT_v98_i4_sS_COVER.indd 1 99/26/2020/26/2020 110:05:330:05:33 PPMM ASSOCIATE EDITORS P. Toby Coates, Adelaide Transplant and Immunology Olivier Devuyst, Zurich Physiology, Genetics, Kidney Cancer Tilman B. Drueke, Paris CKD, Hypertension, Nephrolithiasis EDITOR NEPHROLOGY DIGEST EDITOR Jürgen Floege, Aachen Pierre Ronco, Paris Christina Wyatt, New York Glomerulonephritis, CKD-MBD Clinical Investigation Agnes B. Fogo, Nashville Clinical and Experimental Renal Pathology STATISTICIANS DEPUTY EDITOR T. Alp Ikizler, Nashville Vic Hasselblad, Jacksonville Dialysis, Acute Kidney Injury, Nutrition, Metabolism Brad Rovin, Columbus Zhezhen Jin, New York Masaomi Nangaku, Tokyo Translational Nephrology Joseph Kim, Toronto Clinical and Experimental CKD Yi-Ju Li, Durham and Diabetic Kidney Disease Dorothea Nitsch, PAST EDITORS London Jai Radhakrishnan, New York Rajasekhar Ramakrishnan, New York Detlef Schlöndorff, New York Editor KIR, Clinical Studies, Images in Nephrology, Qais Al-Awqati, New York Make Your Diagnosis Saulo Klahr, St. Louis KI FELLOWSHIP INTERNS Germaine Wong, Sydney Thomas E. Andreoli, Little Rock Anna Francis, Brisbane Life Course Epidemiology, Health Economics Roscoe R. Robinson, Durham Sethu Madhavan, Columbus and Onconephrology EDITORIAL BOARD Anupam Agarwal, Birmingham Michelle Hladunewich, Toronto Mark Okusa, Charlottesville Evren Azeloglu, New York Fan Fan Hou, Guangzhou Juan Oliver, New York Sean Barbour, Vancouver Pascal Houillier, Paris Cristian Pattaro, Bolzano Jonathan Barratt, Leicester Chi-yuan Hsu, San Francisco Aldo Peixoto, West Haven David Basile, Indianapolis Tobias B. -
Fifty Years of Pancreatic Islet Pathology in Human Type 1 Diabetes: Insights Gained and Progress Made
Diabetologia (2018) 61:2499–2506 https://doi.org/10.1007/s00125-018-4731-y REVIEW Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made Noel G. Morgan1 & Sarah J. Richardson1 Received: 18 June 2018 /Accepted: 13 August 2018 /Published online: 25 September 2018 # The Author(s) 2018 Abstract Type 1 diabetes is increasing in incidence in many parts of the world and it might be imagined that the pathological processes that underlie disease progression are firmly understood. However, this is not the case; rather, our collective understanding is still surprisingly rudimentary. There are various reasons for this but one of the most important is that the target organ (the pancreas) has been examined at, or soon after, diagnosis in only a small number of cases worldwide over the past half a century. This review provides a summary of some of the insights gained from these studies and highlights areas of ongoing uncertainty. In particular, it considers the process of insulitis (a form of islet inflammation that occurs characteristically in type 1 diabetes) and discusses the factors that may influence the access of immune cells to the beta cells. Attention is also drawn to recent evidence implying that two distinct profiles of insulitis exist, which occur differentially in people who develop type 1 diabetes at increasing ages. Emphasis is also placed on the emerging (and somewhat surprising) consensus that the extent of beta cell loss is variable among people with type 1 diabetes and that many (especially those who are older at onset) retain significant numbers of insulin-producing cells long after diagnosis. -
BIOGRAPHICAL SKETCH NAME: Johan AUWERX, M.D., Ph.D. Era
OMB No. 0925-0001 and 0925-0002 (Rev. 03/2020 Approved Through 02/28/2023) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Johan AUWERX, M.D., Ph.D. eRA COMMONS USER NAME (credential, e.g., agency login): AUWERX POSITION TITLE: Professor at the Ecole Polytechnique Fédérale Lausanne (EPFL), Switzerland EDUCATION/TRAINING COMPLETI INSTITUTION AND LOCATION DEGREE FIELD OF STUDY ON DATE Catholic University of Leuven, Leuven, Belgium B.S. 1979 Biochemistry & Genetics Catholic University of Leuven, Leuven, Belgium M.D. 1982 Medicine Catholic University of Leuven, Leuven, Belgium Resident 1982-1986 Intern. Med/Endocrinology Catholic University of Leuven, Leuven, Belgium Ph.D. 1990 Molecular Endocrinology University of Washington, Seattle, WA Post-doc 1986-1988 Molecular Endocrinology ECFMG / VQE M.D. 1982 A. Personal Statement I am trained as a physician scientist and have extensive research expertise and experience in cellular and molecular physiology, metabolism, and genetics developed in C. elegans, mice, and humans. I have been using systems approaches to map the signaling networks that coordinate the communication between the nucleus and the mitochondria and as such regulate organismal metabolism in health, aging, and disease. Although my research has addressed basic biomedical questions, my medical background facilitated the translation of his research into novel preventive and therapeutic strategies for common age-related diseases, such as type 2 diabetes, obesity, atherosclerosis, and frailty, as well as for rare inherited mitochondrial diseases. The translational value of my work is testified by the fact that several drugs targeting processes and pathways, which I elucidated are currently used in the clinic. -
EASD FP 19 Gesamt Internet.Pdf
Umschlag_fp_19_Internet.qxp_Layout 1 02.07.19 13:02 Seite 1 Umschlag_fp_19_Internet.qxp_Layout 1 02.07.19 13:02 Seite 2 55TH ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES Content Page EASD . 4 General Information . 10 EASD Community Plaza . 14 Programme at a Glance . 22 EASD e-Learning . 30 EFSD Mentorship Programme . 31 EUDF Symposia . 32 Tuesday, 17 September . 34 Claude Bernard Lecture . 34 Poster Event A . 45 Poster Event B . 48 Camillo Golgi Lecture . 56 Albert Renold Lecture . 58 Rising Star Symposium . 60 Wednesday, 18 September . 62 Poster Event C . 74 Poster Event D . 77 Diabetes Prize for Excellence Lecture . 84 Thursday, 19 September . 89 Poster Event E . 100 Poster Event F . 103 Minkowski Lecture . 110 Friday, 20 September . 114 Posters . 131 Index of Presenting Authors . 264 Index of Symposium Speakers . 279 European Foundation for the Study of Diabetes (EFSD) . 281 Symposia on the occasion of the 55th EASD Annual Meeting . 285 Industry Symposia, Meet the Expert Sessions and Exhibition on the occasion of the 55th EASD Annual Meeting (organised by INTERPLAN) . 293 56th EASD Annual Meeting . 324 DEAR MEMBERS AND GUESTS, It will be my great honour and pleasure to welcome you to the 55th Annual Meeting of the European Association for the Study of Diabetes e.V. which will take place in Barcelona from 16 to 20 September 2019. EASD Under the chairmanship of EASD Honorary Secretary, Mikael Rydén, the Scientific Programme Committee selected 1195 abstracts for presentation from a total of 2003 submitted. The outstanding programme will comprise of stimulating symposia, numerous oral and poster presentations as well as Prize Lectures, honouring the achievements of distinguished researchers. -
Spontaneous Diabetes in Dogs and Cats* a Pathological Study
Diabetologia 3, 249-265 (1967) Spontaneous Diabetes in Dogs and Cats* A Pathological Study W. GEPTS and D. TOUSSAINT Department of Pathology and Department of Ophtalmology, Brugmann University Hospital and Fondation M6dieale l~eine Elisabeth, Brussels -- Belgium Summary. A histological study of 30 spontaneously phocytaire tr@s dense duns un riot. -- Ni chez les chiens, ni diabetic dogs and 5 spontaneously diabetic cats is chez les chats, il n'a 6t@ vu de l@sions glom@rulaires iden- presented. -- The islets of Langerhans and the B cells tiques k celles de glom6ruloscl~rose diab~tique humaine. were strongly reduced in number in a large majority of Les l@sions les plus fr@quentes consistaient en un 6pais- the diabetic dogs. The B cells were often degranulated sissement des axes membraneux des touffes glom@rulaires and hydropic. In cases of longer duration, the islets were et une hypertrophic de la paroi des arterioles aff@rcntes. -- scarce and B cells could no longer be found. -- In contrast Duns les r@tines des chiens diab@tiques il existait une to the findings in diabetic dogs, all five cats showed acellularit@ locale ou g6n6ralis@e de la paroi des capillaires. numerous islets and B cells. However in 4 cats, the B cells Un petit hombre de microan@vrysmes ont 6t6 trouv6s showed complete degranulation and hydropic changes, as chez 3 chiens diab@tiques. L'incidence plus faible des in the dogs. In one cat, the B cells had a normal appearance. 16sions de r@tinopathie vasculaire, comparativement aux Extensive hyalin deposits were found in the stroma of the diab~tiques humains, s'explique probablement par la dur6e islets in 2 cats. -
Michael Berger, in Memoriam 02.06
EASD EASD EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES ASSOCIATION EUROPEENE POUR L’ETUDE DU DIABETE · EUROPÄISCHE GESELLSCHAFT FÜR DIABETOLOGIE News Section Rheindorfer Weg 3 · D-40591 Düsseldorf · Germany · Tel: +49-211-7 58 46 90 · Fax: +49-211-75 84 69 29 10/2002 E-mail: [email protected] · Homepage: http://www.easd.org Michael Berger, in memoriam 02.06. 1944–18.08.2002 Balodimos Award, New England Diabetes Associa- tion, Boston, USA (1973); the Ferdinand Bertram Award, German Diabetes Association (1978); the Kellion Award, Australian Diabetes Association (1982); the Arnold Durig Award, Austrian Association for Nu- trition (1982); Louis-Pasteur Medal, ALFEDIAM (1988); the Albert Renold Medal, European Associa- tion for the Study of Diabetes (1980); the 1993 Medal of Honour, Faculty of Medicine, Sofia University, Bulgaria (1993); the Mizuno Award Osaka, Japan (1993); and the Claude Bernard Lecturer of EASD (1995). Michael Berger became honorary member of the following associations: Union de Travailleurs Sci- entifique, Bulgaria (1977); Diabetes Association of Argentina (1984); Diabetes Association of Paraguay (1984); Rumanian Association for Nutrition and Met- Professor Michael Berger, former President of EASD abolic Diseases (1985); Association for Diabetes and and Editor-in-Chief of Diabetologia, died in Düssel- Nutrition of Uruguay (1990); Bulgarian Association dorf on 18 August 2002, following a long and severe for Internal Medicine (1993); Hungarian Diabetes illness which he bore with courage and dignity. Born Association (1994). He was Guest Professor of Inter- in Schmalkalden, Thüringen, Germany on 2 June nal Medicine, University of Benghazi, Libya (1983); 1944, Michael Berger went to medical school from Honorary President, Diabetes Association of Ecuador 1963-1969 at the universities of Würzburg/Germany, (1986) and a Member of the Academy of Medicine of Galway/Ireland and Düsseldorf/Germany and received Romania (1994). -
Outputs, Outcomes and Impact of MRC Research 2014/15 Report
Outputs, outcomes and impact of MRC research 2014/15 report European Union (EU) Scale: 1 Collaboration ISBN 978-0-903730-22-8 © Medical Research Council copyright 2016 You may re-use this information (excluding logos, images and icons) free of charge in any format or medium, under the terms of the Open Government Licence. To view this licence, visit http://www.nationalarchives.gov.uk/doc/open-government-licence/ or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or e-mail: [email protected] When providing a citation for this document we recommend the following: Medical Research Council (2016) MRC Outputs, outcomes and impact of MRC research 2014/15 report. Publisher: Medical Research Council, London, UK. ISBN: 978-0-903730-22-8 Any enquiries related to this publication should be sent to us at: Medical Research Council, 14th Floor, One Kemble Street, London WC2B 4AN or [email protected] This publication is available at https://www.mrc.ac.uk/successes/outputs-report/ Table of Contents List of case studies by primary output type 3 SECTION 1.0: Introduction 7 Overview 9 Key 11 researchfish® 12 SECTION 2.0: Case studies 15 2.1: Published research 17 2.2: Policy and engagement 37 2.3: Development of products and intellectual property 65 2.4: Research materials 107 2.5: Industry interactions and other collaborations 135 2.6: Awards and recognition 165 SECTION 3: Quantitative analysis 179 3.1 Publications 181 3.2: Collaborations 186 3.3 Further funding 191 3.4 Next destination 198 3.5 Engagement activities 201 3.6 Influence on policy 205 3.7 Research materials – tools and methods, databases and models 210 3.8 Intellectual property 215 3.9 Products and interventions 219 3.10 Awards and recognition 225 Front cover image credits Mosquito on human skin at sunset. -
FINAL PROGRAMME Programme Final Fp1 2013__ 15.08.13 10:32 Seite 2
Title_Final_prog2013__ 15.08.13 10:51 Seite 1 Final Programme EASD 2013 FINAL BARCELONA PROGRAMME fp1_2013__ 15.08.13 10:32 Seite 2 49th annual meeting oF the euroPean association For the study oF diabetes scientific Programme Page European Foundation for the Study of Diabetes 10 General Information 14 Map of the Conference Centre 22 Programme at a Glance 24 Monday, 23 September 34 EASD App 35 Tuesday, 24 September 36 Opening Ceremony 37 Minkowski Lecture 37 Poster Event A and B 45 Camillo Golgi Lecture 55 Albert Renold Lecture 57 Rising Star Symposium 58 Wednesday, 25 September 60 Poster Event C and D 69 Thursday, 26 September 82 Poster Event E and F 91 EASD General Assembly 102 Friday, 27 September 104 Claude Bernard Lecture 119 Closing Ceremony 120 Posters 121 Index of Presenting Authors 276 Index of Invited Speakers 293 50th Annual Meeting 296 2 fp1_2013__ 15.08.13 10:32 Seite 3 dear members, dear guests, From 23 to 27 september it will be my great honour and pleasure to welcome you to the 49th easd annual meeting. under the outstanding chairmanship of our honorary secretary, Prof. mark Walker, the scientific Programme committee has selected 1361 from a total of 2321 submitted abstracts for presentation this year. the scientific Programme comprises six parallel tracks which include inspiring symposia, keynote lectures and debates covering basic and clinical science. the scientific Programme reflects the ongoing efforts to understand, cure and prevent diabetes. our main hall is named after claude bernard in order to celebrate his 200th birthday. 30 years ago saw the inception and planning of the dcct, and the final results of the uKPds were presented at the 34th easd annual meeting in barcelona. -
ETH ZURICH Annual Report 2007 Annual Reportannual 2007 Zurich ETH ETH Zurich Annual Report 2007
ETH Zurich Annual report 2007 ETH ZURICHETH Annual report 2007 ETH Zurich annual report 2007 Contents Donations 4 Portrait of ETH 6 Foreword from the President 8 Teaching 10 Research 12 Planning 14 ETH and industry 16 ETH and the climate 22 ETH and medicine 28 Cultural facilities 34 Picture gallery 38 Facts and figures: Highlights 40 Facts and figures 44 Honors at the ETH Day 64 Other honors for ETH staff 66 Organizational chart 73 3 Donations to ETH Zurich and the ETH Zurich Foundation Many thanks! The following companies, foundations and private individuals have given financial support to ETH Zurich and the ETH Zurich Foundation in 2007, or have promised a donation1. ETH Zurich is grateful to everyone who supports it for their valuable contributions and for their confidence. Companies GSM Association ABB Schweiz AG Hans Süsli Stiftung Ascom (Schweiz) AG Hasler Stiftung Avaloq Helmut Horten Stiftung Bühler AG HFSP Human Frontier Science Program Organization Collano AG Hirschmann-Stiftung Credit Suisse Group Zürich Holcim Foundation for Sustainable Constructions De Beers Consolidated Mines The Holcim Foundation for the Advancement Det Norske Oljeselskap AS of Scientific Research Glencore International AG International Foundation of Research in Paraplegia Gübelin AG JDRF Juvenile Diabetes Research Foundation F. Hoffmann-La Roche Ltd. Jubiläumsstiftung der Schweizerischen Mobiliar Hilti Schweiz AG Genossenschaft Johnson Matthey & Brandenberger Körber-Stiftung Mineral Consult AG Krebsliga des Kantons Zürich Novartis Pharma AG Krebsliga Zentralschweiz