2015 Annual Meeting

PROGRAM BOOK

MGMa Gr nd Hotel Las Vegas, Nevada March 28 – 31 Annual Meeting supporters T he Orthopaedic Research Society would like to thank the following corporate partners for their generous support.

Thank you to our 2015 Video Outreach Competition Sponsors

Micro Photonics Inc. Instrumental to your success

Thank you to our 2015 NIRA (New Investigators Recognition Award) Supporters

ii Table of Contents

Annual Meeting Corporate Supporters ...... Page ii TION

Meeting Information and Schedules...... Page v MA

New Investigator Meeting at a Glance...... Page 6 INFOR

L Future ORS Annual Meetings...... Page 9 A

Meeting Objectives / CME / FDA / Disclaimers / Safety Tips / GENER Guest Badge Information Page...... Page 10

Membership Information...... Page 13

Friday, March 27...... Pages 15

Saturday, March 28...... Pages 16-25

Sunday, March 29...... Pages 26-36

Monday, March 30...... Pages 37-43

Tuesday, March 31...... Pages 44-49

Poster Sessions...... Pages 50-149

Exhibitor Listing and Floor Plan...... Pages 150-157

iii GENER Welcome to the ORS 2015 Annual Meeting

L Saturday, March 28 – Tuesday, March, 31 , 2015

INFOR MGM Grand Hotel | Las Vegas, Nevada

MA Dear Fellow ORS Members, Colleagues, and Guests,

TION On behalf of the Orthopaedic Research Society, we welcome you to the ORS 2015 Annual Meeting!

For more than 60 years, the ORS Annual Meeting has been a home for those in the field of musculoskeletal research from around the globe. Providing a forum that allows communication and collaboration among our multi-disciplinary attendees has always been one of the primary purposes of the society and the Annual Meeting.

We invite you to join us for the Welcome Session where we will introduce our international partners and honor Japan as our first Guest Nation. We will also invite Mellissa Marshall to the stage. Best known for her TEDtalk, “Talk Nerdy to Me,” Marshall will share how effective communication serves as the foundation to advance research. She will help attendees better communicate their science, a key challenge for the advancement of our field.

Once again, we are looking forward to offering the ORS/OREF Basic Science Course, ORS Clinical Research Forum, and the Translational Symposium, Cartilage Repair: Is it Possible? In addition to the workshops and spotlight sessions that will cover a broad spectrum of research activities, we will host a new workshop organized by The Journal of Orthopaedic Research (JOR) to help authors learn strategies for increasing their success of publishing their research. In addition to her keynote address, Melissa Marshall will give researchers a new skill set for communicating their science in her workshop: Present Your Science: Transforming Technical Talks.

Thank you to all of our many dedicated volunteers and to our members. The success of the society and the Annual Meeting would not be possible without your support!

At this year’s meeting, we hope that you find many opportunities to collaborate, communicate, and gain inspiration to accelerate the pace of discovery.

Enjoy your time in Las Vegas!

Sincerely,

Mary B. Goldring, PhD ORS President

iv SCHEDULE

INNOVATION CENTRAL (POSTER AND EXHIBIT HALL)

Marquee Ballroom - Complimentary Wi-Fi, Innovation Theater, Charging Stations, seating , Refreshment Breaks, Food for Purchase TION

Saturday, March 28 12:00 PM – 8:00 PM MA Sunday, March 29 9:00 AM – 6:00 PM Monday, March 30 9:00 AM – 5:30 PM INFOR Tuesday, March 31 6:00 AM – 3:30 PM (no exhibits) L A SPEAKER READY ROOM

Grand Ballroom 123 GENER

Saturday, March 28 7:00 AM – 6:00 PM Sunday, March 29 7:00 AM – 5:00 PM Monday, March 30 7:00 AM – 4:30 PM Tuesday, March 31 7:00 AM – 3:00 PM

CHECK-IN and REGISTRATION

Grand Ballroom Pre-Function Area

Friday, March 27 5:00 PM – 8:00 PM Saturday, March 28 7:00 AM – 5:30 PM Sunday, March 29 7:00 AM – 5:30 PM Monday, March 30 7:00 AM – 5:30 PM Tuesday, March 31 7:00 AM – 3:00 PM

D onate to the ORS/OREF GRANTS CAMPAIGN TODAY!

By giving to the ORS/OREF Grants Campaign, All donors will also receive a you enable orthopaedic residents and post- special thank you from the ORS. doctoral ORS members to pursue important All donations over $25 – you will be entered research that may one day translate into into a raffle for free registration for the ORS 2016 Annual Meeting in Orlando, Florida. innovative new treatments and therapies Donate $25 – $49 a beverage voucher to be used that help patients recover their mobility during one of the two ORS Poster Receptions. and enjoy an improved quality of life. Donate over $50; an ORS fleece jacket.

GIVE TODAY! Please visit the ORS exhibit booth to make your donation and receive your gift.

v ORS Board of Directors 2014-2015 Annual Meeting Committee Mary B. Goldring, PhD...... President Mathias P.G. Bostrom, MD...... 1st Vice President Mathias P.G. Bostrom, MD, Chair GENER Farshid Guilak, PhD...... 2nd Vice President Yupeng Chen, PhD (Associate Member) Joan E. Bechtold, PhD...... Past President Susanna G. Chubinskaya, PhD

A Marjolein van der Meulen, PhD...... Secretary

L George R. Dodge, PhD

INFOR Kristy Weber, MD...... Secretary Elect Tammy L. Haut Donahue, PhD Gloria Matthews, DVM, PhD...... Treasurer Farshid Guilak, PhD

MA X. Edward Guo, PhD...... Member-At-Large Karen King, PhD

TION Peter Amadio, MD...... Member-At-Large Sheldin Lin, MD Devina Purmessur, PhD...... Member-At-Large David W. Schroeder Kurt Hankenson, DVM, PhD...... Membership Committee Chair Ex-Officios Matthew Allen, PhD...... Communications Council Chair Christopher Evans, PhD...... Editorial Advisory Board Chair Program Committee George Dodge, PhD...... New Initiatives Committee Chair Farshid Guilak, PhD, Chair Tamara Alliston, PhD...... Professional Development & Mentoring Council Chair Andrea I. Alford, PhD Susanna G. Chubinskaya, PhD, ORS Staff Poster Chair Brenda Frederick...... Executive Director Sibylle Grad, PhD Amber Blake...... Communications Manager Christopher J. Hernandez, PhD Mary Jo Heflin...... Education Manager Douglas D. Robertson, Jr., MD, PhD Jola Lewsza...... Professional Development Program Manager Alyson Scolaro...... Administrative/Exhibits Coordinator Bailey Slechta...... Membership Coordinator Matt Zuleg...... Education Coordinator

T opic Chairs The ORS Board of Directors, Annual Meeting and Program Clinical/AnatomicAL Topics Committees would like to acknowledge the Topic Chairs Hip and Knee Arthroplasty...... John DesJardins, PhD for their contribution to the 2015 Annual Meeting Program...... and Nico Verdonschot, PhD Knee...... Guoan Li, PhD

TISSUE BASED TOPICS Hip...... Lee E. Rubin, MD Biomaterials...... Fergal J. O’Brian, PhD Spine...... Makarand V Risbud, PhD, ...... Ashish D. Diwan, MD, Keita Ito, MD Cartilage, Synovium & Osteoarthritis.... Timothy Griffin, PhD, ...... Anne-Marie Malfait, MD and Matthew Stewart, PhD Shoulder and Elbow...... C. Benjamin Ma, MD Meniscus...... Lutz Dürselen, PhD Hand and Wrist...... Aaron Daluiski, MD Tendon/Ligament...... Helen Lu, PhD Foot and Ankle...... Samuel B. Adams, MD Muscle...... Sameer B. Shah, PhD Infection...... Paul H. Wooley, PhD Bone/Bone Biology...... Edward Purdue, PhD Trauma...... David J. Hak, MD ...... and Vicki Rosen, PhD Cancer, Tumors...... Richard M. Terek, MD Bone Fracture...... Elise F. Morgan, PhD Diagnostic Imaging...... Hollis Potter, MD 2 “ We’re developing a system that would enable physicians to make a quick and reliable analysis of a patient’s fracture risk.” ORS member Ara Nazarian, DrSc

Dr. Nazarian (left) and research assistant Shohreh Behrouzi Photo courtesy of Mr. Ohan Manoukian Calculating fracture risk Ara Nazarian, DrSc, co-principal investigator Brian Snyder, MD, PhD, and Every gift makes a difference their colleagues are using the principles of Since 1955, ORS and OREF have worked together to beam theory—a calculation that factors expand funding for clinically relevant research and in both geometric and material properties to increase opportunities for new investigators. Now, determine rigidity—to design a computerized the two organizations have collaborated to create tomography (CT)-based rigidity analysis that the ORS/OREF Resident Research Grant and Post- Doctoral Fellowship Grant Fund. can determine the risk of fractures in bones with metastasized lesions. Gifts to this fund: • Enable post-doctoral ORS members to devote An OREF Prospective Clinical Research their time and resources to research that may one day translate into innovative new treatments and Grant gave Dr. Nazarian and his colleagues therapies. the funding they needed to conduct a • Assist ORS resident members who are exploring multicenter study assessing the utility of careers in research. the CT-based rigidity analysis. Read more at • Support ORS and OREF missions to advance www.oref.org/AraNazarian. orthopaedic research.

Make your gift today at www.oref.org/orsgrant.

For more information, please contact: Ed Hoover, VP, Development Angela David, Development Specialist (847) 430-5105 I [email protected] (847) 430-5115 I [email protected]

45th INterNAtIONAl Sun Valley Workshop: Musculoskeletal Biology

New Mechanisms for Old Problems

Program HigHligHts ■ Cell Signaling and the Coupling of Career Development Bone Resorption and Formation Workshop for ■ Nerves, Bone, Joint Pain and Young investigators Skeletal Homeostasis ■ The Identification, Regulation and Awards available to Importance of Cortical Porosity offset travel expenses ■ Using Bioimaging and 3D for young and Printing to Regenerate under-represented Musculoskeletal Tissue minority investigators ■ Perilacunar Remodeling

www.ors.org/sunvalley NEW INVESTIGATOR MEETING AT A GLANCE

GENER Sa turday, March 28 Mond ay, March 30

Mentor Connect Industry Connect A

L 11:00 am – 12:00 pm 12:30 pm – 1:30 pm

INFOR Room 115 Room 116

MA New Investigator Networking Session – New Investigator Networking Session –

TION Position Yourself for a Successful Career: Position Yourself for a Successful Career: Strategic Lab and Time Management Setting Foundational Early Career Goals 11:00 am – 12:00 pm 12:30 pm – 1:30 pm Room 117 Room 121 - 122

PA S I: Career Advancement: Poster Walking Tours Winning the Uphill Battle for Research Funding 12:30 pm – 1:30 pm 3:00 pm – 4:30 pm Innovation Central/Marquee Ballroom Room 121 – 122 PAS III: Rising to the Top: ORS President’s Welcome Reception Leadership Success in Academics 6:00 pm – 8:00 pm 1:45 pm – 3:15 pm Marquee Ballroom Room 121 – 122

Poster Reception 4:15 pm – 5:30 pm S unday, March 29 Innovation Central/Marquee Ballroom

New Investigator Networking Session – Women’s Leadership Forum Reception An Inside Look at Research Funding Opportunities 7:30 pm – 10:00 pm with the National Institutes of Health (NIH) Vista Ballroom 12:45 pm – 1:45 pm (Registration and Fee required) Room 115

Poster Walking Tours 12:45 pm – 1:45 pm T uesday, March 31 Innovation Central/Marquee Ballroom Poster Walking Tours PAS II: Finding a Partner in Research 11:30 am – 12:30 pm 2:00 pm – 3:30 pm Innovation Central/Marquee Ballroom Room 121 – 122

Poster Session 4:45 pm – 6:00 pm Innovation Central/Marquee Ballroom

6 JAPAN ORS Guest NatiON TION The ORS welcomes Japan, the inaugural Guest MA Nation to be honored at the ORS 2015 Annual Meeting. The Guest Nation Program honors our INFOR colleagues in Japan, recognizes their contribu- L tion to the field of musculoskeletal research, and A celebrates our long-standing partnership with the Japanese Orthopaedic Association. GENER

The Japanese Orthopaedic Association was founded in 1926 maintenance and improvement of bone and joint function. (Year 15 of the Taisho era) in order to promote studies of To achieve this, it will be necessary to produce medical orthopaedics, presentation of study results, and to strengthen specialists who are adept at diagnosis and treatment, contact and cooperation among organizations and individuals including conservative treatments such as therapeutic specializing in this discipline. Our goal is to facilitate the exercise, as well as pharmacotherapeutics and surgery.

Connect with ORS for the latest #ORS2015 Annual Meeting information!

LIKE us on Facebook FOLLOW @ORSsociety on Twitter #ORS2014

JOIN the conversation on LinkedIn WATCH us on YouTube

Don’t forget to download the ORS 2015 Annual Meeting Mobile App! HTTP://ORS.SHOWPRG.COM

7 Be a part of the ORS Spine Section communitY!

GENER The Spine Section’s mission is to advance spine research and related sciences as to improve patient care through basic, translational and clinical research. The Spine Section is also committed to providing leadership by representing researchers in A

L the Orthopaedic Research Society

INFOR

ORS Spine Section dues are $50 for current ORS members*. ORS Spine Section dues MA are in addition to ORS annual membership dues. TION Stop by the ORS Booth to find out more information on how to join theORS Spine Section and be a part of a community of spine researchers!

*Not an ORS member? Interested in joining ORS? Ask us how to join today or visit ors.org for more information.

TRANSPORTATION INFORMATION

ORS will provide complimentary shuttle service between the MGM Grand Hotel and the Venetian/Sands EXPO (AAOS Annual Meeting) Friday, March 27 & Saturday, March 28.

FRIDAY, MARCH 27

7:00 AM First Bus Departs MGM Grand Conference Center to Venetian Tour Lobby Bus to depart MGM Grand Conference Center to Venetian Tour Lobby every hour on the hour Bus to depart Venetian Tour Lobby to MGM Grand Conference Center every hour on the ½ hour 5:00 PM Last Shuttle Departs MGM Grand Conference Center 5:30 PM Last Shuttle Departs Venetian Tour Lobby

SATURDAY, MARCH 28

Please note, bus seating is on a first come first served basis.

8 FUTURE ORS ANNUAL MEETINGS! TION MA INFOR

L A

ORS 2016 GENER Annual Meeting

D isney’s © C oronado Springs Resort

O rlando, FL March 5-8, 2016

ORS 2017 Annual Meeting S an Diego Convention Center

S an Diego, CA March 19-22, 2017

9 Miscellaneous FDA All drugs and medical devices used in the United States are administered in accordance with Food and Drug Administration (FDA) regulations. These regulations vary depending on the risks GENER associated with the drug or medical device, the similarity of the CONTINUING MEDICAL EDUCATION drug or medical device to products already on the market, and the quality and scope of clinical data available. Some drugs or A This activity has been planned and implemented in accordance L medical devices demonstrated at this 2015 Annual Meeting of the

INFOR with the Essentials Areas and policies of the Accreditation Orthopaedic Research Society may have not been cleared by the Council for Continuing Medical Education through the joint FDA or have been cleared by the FDA for specific purposes only. The sponsorship of the American Academy of Orthopaedic Surgeons FDA stated that it is the responsibility of the physician to determine MA and the Orthopaedic Research Society. The American Academy the FDA clearance status of each drug or medical device he or she TION of Orthopaedic Surgeons is accredited by the ACCME to provide wishes to use in clinical practice. Orthopaedic Research Society continuing medical education for physicians. policy provides that “off label” uses of a drug or medical device may The American Academy of Orthopaedic Surgeons designates this be described in the Orthopaedic Research Society’s CME activities live activity for a maximum of 25.75 AMA PRA Category 1 Credits™. so long as the “off label” use of the drug or medical device is also Physicians should claim only the credit commensurate with the specifically disclosed (i.e., it must be disclosed that the FDA has not extent of their participation in the activity. cleared the drug or device for the described purpose). Any drug or medical device is being used “off label” if the described use is not set Attendees will be able to claim CME from the ORS 2015 Annual forth on the product’s approved label. Meeting by completing the CME form on the ORS website following the meeting in Las Vegas. DISCLAIMER SAFETY TIPS The materials presented at the 2015 Annual Meeting of the Orthopaedic Research Society have been made available by the DO: Orthopaedic Research Society for educational purposes only. • Travel with only the credit card and ID cards you will use. The material is not intended to represent the only, nor necessarily • Check that the lock works and that the door closes securely in best, method or procedure appropriate for the medical situations your hotel room. Put the chain or deadbolt on the door after discussed, but rather is intended to present an approach, view, entering the room. statement or opinion of the faculty, which may be helpful to others • Walk with another person. Single targets are the most likely who face similar situations. The Orthopaedic Research Society victims of crime. disclaims any and all liability for injury or other damages resulting to any individual attending the meeting and for all claims, which DON’T: may arise out of the use of the techniques demonstrated therein • Wear your badges or carry conference bags outside. by such individuals, whether these claims shall be asserted by • Walk in dark, isolated areas, such as closed plazas physician or any other person. No reproduction of any kind, including audiotapes and videotape, may be used in any portion Children 16 years of age and under are not permitted to enter of the ORS Annual Meeting. The ORS reserves all of its rights to such the exhibit and poster hall area or the session rooms at any time. material, and commercial reproduction is specifically prohibited. No supervision is offered.

MEETING OBJECTIVES Image Consent Policy By attending the 2015 ORS Annual Meeting you give your consent, • To present the best available research from unless you notify us otherwise, to use your image captured during all disciplines of musculoskeletal research. the conference through video, photographs, or digital imagery, to • To promote the exchange of ideas and encourage be used by the ORS in promotional materials, publications, and web collaborations in orthopaedic research. site and waive any and all rights to these images. • To encourage promising and emerging areas in musculokeletal research including basic science education, and research Filming/Recording Policy strategies by use of forums, workshops, special sessions The photography or recording of any kind (cell phone, camera, and special interest meetings. video recorder, etc) of a scientific presentation, educational program, workshop, posters, or meetings of the ORS is strictly forbidden without prior approval in writing by the ORS. This policy will be strictly enforced.

10 COMMITTEE MEMBERS The ORS would like to thank the following 2014 ORS Committee Members.

AAOS/ORS Research Martin Stoddart, PhD Ex-officios Natalie Kelly, BS (Associate Member) Programming Committee Zongbing You, MD, PhD Mathias P.G. Bostrom, MD Francis Y. Lee, MD Mathias P.G. Bostrom, MD, Co-Chair Ex-Officio Members Kristy L. Weber, MD X Lucas Lu, PhD TION William M. Mihalko, MD, PhD, Co-Chair Barbara D. Boyan, PhD, AAOS/FDA/OSMA Jinxi Wang, MD International Committee MA Tamara Alliston, PhD Device Forum Tamara Alliston, PhD (Ex-Officio) Peter C. Amadio, MD Hani Haider, PhD, AAOS Committee on John Antoniou, MD, PhD, FRCSC, Biomedical Engineering Co-Chair Nominating Committee INFOR

Susanna G. Chubinskaya, PhD Warren O. Haggard, PhD, AAOS/FDA/OSMA Theodore Miclau, MD, Co-Chair Joan E. Bechtold, PhD, Chair L

James Ficke, MD A Device Forum Mauro Alini, PhD Susan V. Bukata, MD Farshid Guilak, PhD Lynne C. Jones, PhD, AAOS Committee on Mats Brittberg, MD, PhD Victor Y. Leung, PhD John S. Kirkpatrick, MD, PhD Biologigical Implants Zigang Ge, MD, PhD Elise F. Morgan, PhD GENER Ruth Thomas, MD Clinical Research Committee Edward Guo, PhD Fackson Mwale, PhD Thomas Throckmorton, MD Kurt P. Spindler, MD, Chair David Little, MBBS, FRACS, PhD Ling Qin, PhD Advocacy Roy K. Aaron, MD Niamh Nowlan, PhD Vani J. Sabesan, MD Lynne C. Jones, PhD, Chair Theodore Miclau, MD (Ex-Officio) Michiaki Takagi, MD, PhD Matthew J. Silva, PhD Chelsea Bahney, PhD Saam Morshed, MD Nico Verdonschot, PhD Chenfung Zhao, MD Scott Bruder, MD, PhD George F. Muschler, MD Media Relations and Program Committee Megan Killian, PhD Kristy L. Weber, MD Communications Committee Farshid Guilak, PhD, Chair Jeremiah Easley, DVM Michael J. Yaszemski, MD, PhD Anton Bowden, PhD, Chair Andrea I. Alford, PhD Glen Niebur, PhD John A. Anderson, MD Corporate Affairs Committee Susanna G. Chubinskaya, PhD David Rowe, MD Alan Dang, MD David W. Schroeder, BS, MBA, Chair Sibylle Grad, PhD Vaida Glatt, PhD Annual Meeting Committee Jacob Cartner, MS (Associate Member) Christopher J. Hernandez, PhD Aidin Masoudi, MD Mathias P.G. Bostrom, MD, Chair Jason P. Lusk, MS Douglas D. Robertson, Jr., MD, PhD Yupeng Chen, PhD (Associate Member) Michael S. Ominsky, PhD J. Patrick O’Connor, PhD Volunteer Susanna G. Chubinskaya, PhD Jeremy Rawlinson, PhD Bettina Willie, PhD Appointment Committee George R. Dodge, PhD C. William Wu, PhD Editorial Advisory Board, Joan E. Bechtold, PhD, Chair Tammy L. Haut Donahue, PhD Journal of Orthopaedic Membership Committee Peter C. Amadio, MD Farshid Guilak, PhD Research (JOR) Kurt D. Hankenson, DVM, PhD, Chair Lawrence J. Bonassar, PhD Karen King, PhD Christopher H. Evans, PhD, Chair Lawrence J. Bonassar, PhD Tammy L. Haut Donahue, PhD Sheldin Lin, MD Roy K. Aaron, MD Johnny Huard, PhD Farshid Guilak, PhD David W. Schroeder Matthew Abdel, MD Hubert T. Kim, MD Devina Purmessur, PhD Lyndsey Burton, MD (Associate) Awards and Jonathan Gumico, BS (Ad Hoc member) Women’s Leadership Forum Recognition Committee Mary B. Goldring, PhD Stephen Thorpe, PhD (Ad Hoc member) Karen King, PhD, Chair Sheldon Lin, MD, Chair Marjolein van der Meulen, PhD New Initiatives Committee Robin Queen, PhD Susanna G. Chubinskaya, PhD J. Mark Wilkinson, PhD (FRCS) George Dodge, PhD, Chair Im Hee Jeong Sampen, PhD Farshid Guilak, PhD Ex-officios Jaimo Ahn, MD, PhD Michelle A Ghert, MD (Ex-Officio) Hannah J. Lundberg, PhD Linda Sandell, PhD, Editor-in-Chief, JOR Editor Ken Kozloff, PhD Advisory Board Min Jung Park, MD (Associate Member) Deepak Vashishth, PhD Finance Committee Adele Boskey, PhD Basic Science Education Jamie R. Williams, PhD Clare Rimnac, PhD Committee Gloria Matthews, DVM, PhD, Chair New Investigator Linda Sandell, PhD Matthew J. Allen, Vet MB, PhD, Chair Peter C. Amadio, MD Mentoring Committee Alexis Dang, MDOS Joan E Bechtold, PhD Tammy Haut Donahue, PhD, Chair Michael A. Liebschner, PhD Mary B. Goldring, PhD Diana Glaser, PhD (Ad-Hoc Member) Zvi Schwartz, DMD, PhD Marjolein van der Meulen, PhD James C. Iatridis, PhD Gulshan Sharma, PhD

11 Thank you to the Adjunct Reviewers The ORS Board of Directors and Program Committee would like to thank all the volunteers for their time, effort, and dedication to the Society and the 2015 Annual Meeting. GENER Roy K. Aaron, MD Ashish D. Diwan, MD David A. Hoey, PhD Hue H. Luu, MD Paul J. Rullkoetter, PhD Matthew P. Abdel, MD Matt Dressler, PhD Ali Hosseini, PhD C. Benjamin Ma, MD James T. Ryaby, PhD

A Douglas J. Adams, PhD Lutz Dürselen, PhD Judith Hoyland, PhD Henning Madry, MD Simo Saarakkala, PhD L

INFOR Samuel B. Adams, MD Tithi Dutta Roy, PhD Alice Huang, PhD Suzanne A. Maher, PhD Sophia N. Sangiorgie, PhD Anand Agarwal, MD Edward Ebramzadeh, PhD James C. Iatridis, PhD Anne-Marie Malfait, MD Jonathan Schiller, MD Animesh Agarwal, MD John J. Elias, PhD Carl W. Imhauser, PhD Kenneth A. Mann, PhD Tannin Schmidt, PhD MA Jaimo Ahn, MD, PhD Isaac E. Erickson, PhD Serkan Inceoglu, PhD Koichi Masuda, MD Hans F. Schmotzer, PhD

TION Andrea I. Alford, PhD Alejandro A. Espinoza Orias, PhD Andreia Ionescu, PhD Mathew T. Mathew, PhD Joseph H. Schwab, MD Kyle D. Allen, PhD Brian Feeley, MD Keita Ito, MD Kevin McHugh, PhD Lori Setton, PhD Peter C. Amadio, MD Stephen J. Ferguson, PhD Alicia R. Jackson, PhD Amy McNulty, PhD Sameer B. Shah, PhD Donald D. Anderson, PhD David M. Findlay, PhD Holger Jahr, PhD John B. Medley, PhD Hani A. Awad, PhD Matthew Fisher, PhD Brian Johnstone, PhD Christopher L. Mendias, PhD Gulshan B. Sharma, PhD Won Bae, PhD Daniel C. Fitzpatrick, MD Niraj V. Kalore, MD Meghan M. Moran, PhD Jason Shearn, PhD Chelsea Bahney, PhD Braden C. Fleming, PhD Amir Kamali, PhD Elise F. Morgan, PhD Julia C. Shelton, PhD Scott A. Banks, PhD Lisa A. Fortier, DVM Helen Kambic, PhD Michael M. Morlock, PhD Robert A. Siston, PhD Thomas W. Bauer, MD, PhD Kharma Foucher, PhD Rita Kandel, MD Annegret Muendermann, PhD Lachalan Smith, PhD Joan E. Bechtold, PhD Darin Friess, MD Galateia J. Kazakia, PhD Martha M. Murray, MD Stephen Spiegelberg, PhD Michael J. Bey, PhD Leesa M. Galatz, MD Daniel J. Kelly, PhD Volker Musahl, MD Matthew Steensma, MD Sanghita Bhattacharya, PhD Benjamin Gantenbein-Ritter, PhD Oliver Kessler, MD Fackson Mwale, PhD Matthew Stewart, PhD Leendert Blankevoort, PhD Michael J. Gardner, MD Megan Killian, PhD Raghu N. Natarajan, PhD Aaron Stoker, PhD Joel A. Block, MD Louis C. Gerstenfeld, PhD Karen B. King, PhD Rob P. Nelissen MD, PhD Hui (Herb) Sun, PhD Mathias P. Bostrom, MD Jessica E. Goetz, PhD Jenneke Klein-Nulend, PhD Fred Nelson, MD Pascal Swider, PhD Helena Brisby, MD, PhD Garry Gold, MD Shigeru Kobayashi, PhD Shane J. Nho, MD Michiaki Takagi, MD, PhD Claire Brockett, PhD Said T. Gomaa, PhD Matthew Koff, PhD Philip C. Noble, PhD Johnna S. Temenoff, PhD Robert Brophy, MD Enrique Gomez-Barrena, MD Andreas Kontaxis, PhD Niamh C. Nowlan, PhD Stavros Thomopoulos, PhD Sjoerd Bulstra, MD Sibylle Grad, PhD Rami K. Korhonen, PhD Fergal H. O’Brian, PhD Pieter Buma, PhD Timothy Griffin, Phd Kenneth M. Kozloff, PhD A. Lee Osterman, MD Jonathan I. Thompson, PhD Jarett D. Cain, DPM, MSc Helen Gruber, PhD Catherine K. Kuo, PhD Saikat Pal, PhD Weidong Tong, PhD Yupeng Chen, PhD Teja Guda, PhD Mario Lamontagne, PhD Abhay Pandit, PhD Travis Turnbull, PhD Wing-Hoi (Louis) Cheung, PhD Zbigniew Gugala, MD, PhD Lisa Larkin, PhD O. Mark Papuga, PhD Gangadhar Utturkar, MS Susanna Chubinskaya, PhD Farshid Guilak, PhD Michel Laurent, PhD Avinash G Patwardhan, PhD Nico Verdonschot, PhD Roger Cornwall, MD X. Edward Guo, PhD Mitra Lavasani, PhD Ming Pei, MD, PhD Stephen Waldman, PhD David T. Corr, PhD Nancy Hadley-Miller, MD Francis Y. Lee, MD Anthony Petrella, PhD Joseph Wallace, PhD Hayden-William C. Courtland, PhD Lisbet A. Haglund, PhD Bingyun Li, PhD Robert M. Pilliar, PhD James H. Wang, PhD Michael Cross, MD David J. Hak, MD Guoan Li, PhD Robert A. Poggie PhD Vincent Wang, PhD Hollis Potter, MD Magali Cucchiarini, PhD Deborah J. Hall, BS Yen-Shuo (Peter) Liao, PhD Kurt D. Weiss, MD Chitra L. Dahia, PhD Moussa Hamadouche, MD, PhD Fang (Amanda) Lin, Dsc Edward Purdue, PhD Markus A. Wimmer, PhD Aaron Daluiski, MD Hirotaka Haro, MD, PhD Sheldon Lin, MD Tamara K. Pylawka, MD Jianwen Xu, PhD Alexis Dang, MD Joshua D. Harris, MD Christopher Little, DVM, PhD Ling Qin, PhD Shinichi Yamamoto, MD, PhD Eric Darling, PhD Dominik R. Haudenschild, PhD (Xiaowei) Sherry L. Liu, PhD Robin M. Queen, PhD Liu Yang, PhD Michael R. Dayton, MD Tammy L. Haut Donahue, PhD Xuhui (Phillip) Liu, PhD Chamith S. Rajapakse, PhD Richard E. Debski, PhD Markus Heller, PhD Mandi J. Lopez, DVM, PhD Weiping Ren, MD Shang-You Yang, PhD Louis E. DeFrate, PhD Heath B. Henninger, PhD Jeffrey C. Lotz, PhD Douglas D. Robertson, MD, PhD Yener N. Yeni, PhD John D. DesJardins, PhD Christopher Hernandez, PhD Helen H. Lu, PhD Duane Robinson, DVM, PhD Hongchuan Yu, PhD Lei Ding, PhD Howard J. Hillstrom, PhD X. Lucas Lu, PhD Vicki Rosen, PhD Zijun Zhang, MD, PhD Ming Ding, MD, PhD Bang Hoang, MD Hannah J. Lundberg, PhD Marcel E. Roy, PhD Chunfeng Zhao, MD

12 Become a Member of the Orthopaedic Research Society The ORS Membership Committee will be available to discuss membership aspects and benefits as well as endorse applications during breaks and poster session in the ORS booth located in Innovation Central (Poster/Exhibit Hall).

Active Associate (STUDENT) Affiliate TION Information: Active Members are Associate (Student) Membership is available Affiliate Membership is available to lab

elected to the Society to trainees in the area of orthopaedic technicians, lab and private practice MA based on previous research, including individuals who are administrators/managers, and industry scientific contributions pursuing advanced degrees (e.g., MD, DDS, representatives that make a significant and continued DO, MS, , PhD, DVM) or in post-doctoral scientific and/or non-scientific contribution INFOR

participation in the clinical and research training programs to orthopaedic research and the ORS. L

field of research. Active (Residency and Fellowship). Associate Applicants must have two institutional A members pay annual (Student) Members must verify their sponsors; ORS members must write letters dues of $240. training status in the field of orthopaedic of recommendation including significant research for membership. Associate scientific and/or non-scientific contribution of

(Student) Members are expected to apply the applicant. Letters must be on institutional GENER for Active membership when their training letterhead. Affiliate members pay annual dues is completed. Associate (Student) Members of $240. pay annual dues of $50.

Benefits: Prestige of membership 3 3 3

Reduced registration fees at the ORS Annual Meeting 3 3 3

Network of Skilled Professionals 3 3 3

Free subscriptions to ORS Connect 3 3 3

Online Membership Directory 3 3 3

Discounted rate for ORS Career Center 3 3 3

Eligibility for ORS Awards, Fellowships and Grants 3 3

Online Subscription to Journal of Orthopaedic 3 3 Research (12 issues)

No fee to submit manuscripts to Journal of 3 3 3 Orthopaedic Research

Eligibility to serve on ORS Committees, as a reviewer 3 Corporate Affairs Committee only and moderator

Eligibility to serve on ORS Committees as an Ad Hoc 3

REQUIREMENTS: Presentation of a paper at A signature from your Advisor, Dean, Attendance at one or more prior an ORS Annual Meeting Department or Program Chair verifying ORS Annual Meetings. OR Publication of two your training status is required. peer-reviewed journals papers related to orthopaedic research.

13 ORS Welcomes OUR NEW MEMBERS

Irina Timmerman GENER Pegah Abbasnia Lawson Copley Hayam Husseein Jinjin Ma Annie Reza Bernice Aboud Benjamin Corona Kensuke Ikuta Kyle MacGillis H Duane Romo Wei Seong Toh Eduardo Abreu Michele Corrigan Andreia Ionescu Constance Maglaras Scott Rosenfeld Natasha Topoluk Cheryl Ackert-Bicknell Juan Coruna Cale Jacobs Damon Mar Ann Rosenthal Ashley Torres

A Nobuo Adachi Mary Cowman Amanda Jacobson Nicholas Marais Ryan Ross Koji Totoribe L Andrew Adamczyk Michelle Cruz David Jamison Denis Marcellin-Little Adam Rothenberg Francesco Travascio INFOR Naga Suresh Adapala Joanna Dabrowiecka Jessica Jennings Alejandro Marquez-Lara Stephanie Russo Sophia Traven Carin Ahner Michele D’Apuzzo Yangzi Jiang Deborah Mason Fayez Safadi Luke Tregilgas Ameet Aiyanger Chantal de Bakker Ying Jin Vicky Massicotte David Safranski Katie Trella MA Ryuichiro Akagi Ivan De Martino Anthony Johnson Daniel Massimini Comron Saifi Tsung-Lin Tsai Christina Salas Wafa Albaluki Karen de Mesy-Bentley JoshuaJohnson Jonathan Matheny Tsung-Yuan Tsai TION Juan De Rivero Vaccari JosnaJoseph Masatake Matsuoka Giuliana Salazar-Noratto Carolyne Albert Toshinori Tsukanishi Michael Albro Danielle de Villiers YoheiKagawa Andrew McCaskie Matthew Salzer Tadashi Tsukeoka Mazen Al-Hajjar Sean DeBoyace AtsuhitoKakuta Michael McClure Juan Santiago-Torres Ron Alkalay Agnes d’Entremont Akinori Kan Rachel McGuire Rachel Sarabia-Estrada Travis Turnbull Devon Anderson Matteo D’Este Takao Kaneko Dermott McHugh Kimberly Sass Sardar Uddin Ruhi Arslanoglu Christopher DiGiovanni Lana Kang Mia McNulty Akiko Sato Keita Uetsuki Ashkan Aryaei Elise Donovan Kenji Kawate Qingen Meng Taishi Sato Ginu Unnikrishnan Nobuo Asai Brinda Doshi Serra Kaya Gretchen Meyer Michael Schenk Ashish Upadhyay Mohamed Attawia Susan Drapeau Oran Kennedy Arthur Michalek Jonathan R Schiller Sasidhar Uppuganti John Attenello Guoqing Du Mohamed Khalid Nicholas Mignemi Joseph Schwab Ani Ural Umur Aydogan Rupak Dua Bulent Kilic Kimberly Mimnaugh Joseph Schwab Kenneth Urish Rikiya Baba Elaine Duncan Megan Killian Peter Mittwede Andrea Schwartz Chandra Valmikinathan Joel Bach Ivan Duran Makoto Kobayashi Eng Moo Hazal Screen Martijn van den Bosch Daniel Bachman George Dyer Uotani Koji Yu Moriguchi Cynthia Secchieri Devika Varma Jihye Baek Lauren Eichaker John Konicek Shuichi Moriya Anand Segar Samuel Veres Todd Baldini Khaled Elsaid David Kovacevic Jukka Morko Shiree Segev Linda Vi William Barfield Jonathan Elsner Deborah Krakow Mark Morrey Amee Seitz Hiroshi Wada Jennifer Barrett Fei Fang Kelly Krohn Franklin Moutos Stefania Setti Susumu Wada Stephen Barrett Michael Ferko Chad Krueger Iain Murray Aksel Seyahi Shaowei Wang Mark Barton Elisabeth Ferreira Natarajan Kumar Vincent Mutiso Ali Shahi Yufa Wang Aarti Shendy Nicholas Beckmann Andrzej Fertala Tatsuya Kunimoto Jessica Myers Tommy Washington Laurel Kuxhaus Yusuke Nakagawa David Shiovitz Nicole Behnke John Fowler Wei Wei Shohreh Behrouzi Rachel Frank Grzegorz Kwiecien Michael Nasr Rohan Shirwaiker Kurt Weiss Kevin Bell Douglas Fredericks Marie-Noelle Labour Brad Nelson Jakob Sieker Richard Bell Hiromichi Fujie Jean Langlois Scott Nelson Olof Skoldenberg Jason Wilken Sanghita Bhattacharya Tomohiro Fujiwara Daniel Latt Yutaka Nezu Howard Slaff Nick Willett Paul Bills Kiyokazu Fukui Thomas Laumonier Geoffrey Ng Scott Small David Wolfson Joel Boerckel Tomoaki Fukui Christine Le Maitre Shane Nho Harvey Smith Addison Wood Daniel Boguszewski Karina Galoian Beth Lee Tosan Okoro Kyle Snethen Karina Wright James Boorman-Padgett Michael Geary Peter Lee Rene Olivares-Navarrete James Stannard Ling Wu Elizabeth Bradley Matthew Goff Seung Yeon Lee Daniel Oravec Elena Stavenschi Li Xiao Peter Brett Mathilde Granke Whasil Lee Diego Orozro Villasenor Brian Stemper Denghui Xie Caroline Brial Dave (Xiaoyu) Gu Padraic Levings Patrick Orth Laura Stoll Lianping Xing Helena Brisby Baosheng Guo Eric Lewallen Jun Ouyang Alex Stoller Hao Xu Jason Caffrey David Hamilton Cara Lewis Thomas Owen Alvin Su Ryosuke Yamaguchi Marco Caicedo Josa Hanzlik Jingtao Li Toshifumi Ozaki Dai Sugimoto Wei Yao John Callaci Emily Hargrave-Thomas Chao Liang Jukka Pajarinen Yi Sun Oui Soo Yoo Xu Cao Joshua Harris Huizi (Anna) Lin Jesal Parekh Yuya Takakubo Yuichi Yoshii Connie Chamberlain Lorena Havill Jian Hao Lin Saba Pasha Karren Takamura Hongchuan Yu Deva Chan Xiaojuan He Brock Lindsey Taylor Pate Guak Kim Tan ChawonYun Steven Charlebois Sarah Helms Kevin Little Manda Paul Shih Jye Tan Terri Zachos Hiroshi Tanaka Paul Charpentier Corinne Henak Erin Litts Jeffrey Peck Amine Zaoui Jin Liu Sun Peck Kenta Tanaka Miriam Chaudhary Safa Herfat Stephan Zeiter Kathryn Cheah Marietta Herrmann Ming Liu Marianna Peroglio Tingting Tang Marcy Zenobi-Wong Ruei-Ming Chen Marian Hettiaratchi Sonja Lobo Luke Pietrykowski Arun Tatiparthi Yupeng Chen Hannah Heywood Alayna Loiselle Breanne Przestrzelski Kenneth Taylor Alan Zhang Nobuaki Chinzei Malone Hill Rose Long Radu Racasan Aaron Tayor Nianli Zhang Alexander Christ David Hoey Jason Longaray Ramiro Ramirez Matthew Teeter Shurong Zhang Amy Cizik MaCalus Hogan Huadong Lou Austin Ramme Yoshinori Terashima Xia Zhang Paul Clark Catherine Holt LaQuawn Loving Matthew Rasmussen James Thomas Yingze Zhang Rasmus Cleeman Alice Huang Anne Lubbeke Nakul Ravikumar Nathan Thomas Yuan Zhang Daniel Cohen Paul Huddleston Kurt Lucas David Reece Chavaunne Thorpe Zhong Zheng Mitchell Coleman Lisa Husak Thomas Lufkin Heidi Reesink Melanie Timmen Robert Zondervan

14 FRID AY | meeting highlights Friday, March 27, 2015

m 7:00a -6:00pm m 6:00P -8:00pm

AAOS 2015 Annual Meeting Ancillary Event 7:00 AM – 6:00 PM Research Interest Group: Bone Regeneration Venetian/Sands EXPO 6:00 PM – 8:00 PM Room 106 - 107

Organizer: Chelsea Bahney, PhD, Orthopaedic Trauma Institute Y

This is the 3rd annual Bone Regeneration RIG held at the ORS. Our mission is to provide A new insights into important topics in bone repair by leading experts in field in a 1-hour

panel seminar, followed by an opportunity for networking. The theme for this year’s RIG FRID is The Mechanics of Bone Regeneration. Our panel will cover the basic science related to how cells receive and transduce mechanical signals, as well as translational applications for improving repair by optimizing the loading microenvironment and testing the efficacy of the bone regenerate.

15 SATURDAY | meeting highlights Saturday, March 28, 2015

m 8:00a -10:30am Hip Disease, Kinematics, FAI m 3:00P -4:30Pm Room 116

Ancillary Meetings: Advanced Articular Cartilage Workshops: Imaging Techniques Research Interest Group: Growth Factors Spotlight Session Hot Topics in Regulatory Challenges Room 106 - 107 Room 118 - 120 within Orthopaedics Room 111 - 112 Research Interest Group: Intervertebral Disc: Degeneration, Mechanobiology Pain and Treatment ORS/The HIP Society - Biological Aspects Room 115 Spotlight Session of Modular Implant Tribocorrosion Room 121 – 122 New Horizon Workshop Research Interest Group: Room 113 - 114 Orthopaedic Evidence Room 117 m 1:15P -2:15Pm Trials, Tribulations and Triumphs of rd S

A Conducting Prospective Clinical Research TU Research Interest Group: Tendon Studies: The How and Why Room 121 - 122 NIR A Presentations: Room 116

A Bone Biology & Repair

Y Research Interest Group: Quantitative MR Imaging: Research Spine Research Community Room 111 – 112 Applications and Clinical Translation Room 116 (concludes at 10am) Room 118 - 120 Joint Physiology & Mechanics ORS Advocacy Roundtable Room 113 - 114 Professional Advancement Session- Room 111 - 112 Career Advancement: Winning the Uphill Cell Differentiation Fibrosis & Cancer Battle for Research Funding Room 116 Room 121 - 122 m 11:00a -12:00Pm OA & Cartilage Room 118 – 120 m 4:45P -5:45Pm New Investigator Networking Session: Strategic Lab and Time Management Stem Cells & Tissue Repair OUT Room 121 – 122 Room 117 W elcome Session – Guest Nation, Patient Story, Presidential Guest Speaker SOLDMentor Connect OUT Room 118 – 120 Room 115 m 2:00P -6:00Pm SOLD m 6:00P -8:00Pm m 12:00P -8:00Pm ORS/OREF Basic Science Course: Part I Room 117 P resident’s Welcome Reception Poster and Exhibit Hall Open Innovation Central/Marquee Ballroom Marquee Ballroom m 2:30P -3:00Pm

m 12:00P -1:00Pm Refreshment Break Innovation Central/Marquee Ballroom

Sessions: m 2:45P -3:00Pm Bone Disease Room 111 – 112 I nnovation Theater Presentation: Knee Kinematics and Gait THINK Surgical Room 113-114 TCAT™ as a Research Tool Innovation Central/Marquee Ballroom

16 SATURDAY | PROGRAM DETAILS Saturday, March 28, 2015

Ancillary EVENTS Research Interest Group: Tendon 8:00AM-10:30AM Room 121 - 122 Research Interest Group: Organizers: Growth Factors and Musculoskeletal Repair Nelly Andarawis-Puri, PhD, Mount Sinai School of Medicine Room 106 – 107 Evan Flatow, MD, Mount Sinai School of Medicine Louis Soslowsky, PhD, University of Pennsylvania Organizers: Lawrence J. Bonassar, PhD, Cornell University Objectives: Johnny Huard, PhD, University of Pittsburgh This will be the inaugural meeting of the Tendon Research Interest Group. Anyone with interest in tendon research (basic, tissue Objective: engineering, applied, etc) is welcome to attend. This session will Discuss current and future issues in growth begin by summarizing and reporting on the ORS- ISMMS New factor research as they relate to orthopaedic problems. Frontiers in Tendon Research held in NYC last fall). We will then discuss the structure of this group going forward and initiatives of Research Interest Group: interest to grow and enhance the collaborative research efforts. Mechanobiology and Inflammation in Cartilage

Room 115 Y Research Interest Group: A Organizers: The Orthopaedic Evidence and Outcomes Education Christopher T. Chen, PhD, University of Texas Southwestern Organization

Medical Center TU Room 117 A

Alan J. Grodzinsky, ScD, Massachusetts Institute of Technology S rd Organizer: Objectives: Michael P. Dohm, MD, University of Arizona 1) To create a synergetic environment to present new findings in the emerging fields of mechanobiology and inflammation. Objectives: To discuss the development of infrastructure required for outcomes 2) To discuss how mechanotransduction interacts with common projects in orthopaedics, discussion of patient reported outcome signaling pathways (NF-kB, MAPK, STAT, P3k,CBP/p300 and other) measures and functional measures, definition of data levels, and whether there are thresholds or windows (stress and strain) promote and nurture an environment in which we can work to activate the proinflammatory and anti-inflammatory signaling on collaborative projects regarding applications of evidence in pathways in different connective tissues including cartilage, orthopaedic practice, promote and nurture collaborations within ligament, tendon, bone, and IVD. the discipline of orthopaedics between clinician scientists and 3) To review our current understanding on the relationships researchers as well as in a multidisciplinary fashion with other between mechanobiology, inflammation, and tissue remodeling/ organizations interested in the same. healing. ORS Advocacy Roundtable Research Interest Group: Spine Research Community Room 111 – 112 Room 116 (Concludes at 10 AM) Organizer: Organizers: The ORS Advocacy Committee Fackson Mwale, PhD, McGill University We need more money for orthopaedic research! Yet, we often Makarand V. Risbud, PhD, Thomas JeffersonU niversity rely on others to advocate for us. It is more important than ever Daisuke Sakai, MD, PhD, University of California, San Diego to have your voice heard. Come join us to learn how to become James C. Iatridis, PhD, Icahn School of Medicine at Mount Sinai an advocate. Sibylle Grad, PhD, AO Research Institute Rita Kandel, MD, Mount Sinai Hospital The members of the ORS Advocacy Committee invite you to join them for an open discussion on advocating for research funding. Objectives: Attendees will have the opportunity to hear from people who have 1) To develop and strengthen collaborative research. To build visited Capitol Hill on behalf of orthopaedic research. This informal international networks and foster interactions between research roundtable will offer an open discussion on their experiences and groups from different countries (and different continents). To avoid lessons learned from their advocacy efforts. Discussion topic will competition for national funding sources. To include more clinicians include how to get involved in advocacy, what you need to do in the networks for identification of clinically relevant topics. To to be prepared and developing relationships with those that involve also industrial partners. represent you. 2) To identify underdeveloped areas. 3) To enlarge the spine research community. (a) How to recruit more people to the disc field. (b) How to improve publication efficiency of relevant journals. (c) To better involve the disc/spine research in the ORS committee and editorial board of orthopedic and other relevant journals. 17 SATURDAY | PROGRAM DETAILS Saturday, March 28, 2015

NEW INVESTIGATOR NETWORKING SESSION MENTOR CONNECT Position Yourself for a Successful Career: 11:00 AM - 12:00 PM Strategic Lab and Time Management OUT Room 115 OUT 11:00 AM - 12:00 PM Organizers: SOLDRoom 106 - 107 SOLDThe ORS New Investigator Mentoring Committee Organizers: This is an informal and interactive session between mentors and The New Investigator Mentoring Committee mentees. Mentees will be able to choose their mentor from a select group of ORS members who have demonstrated success in Moderators: their career. The mentors and mentees will have the opportunity Nelly Andawaris-Puri, PhD to discuss career establishment and how to balance competing Devina Purmessur, PhD demands in the academic and corporate environments. The The demands of an early career in academics can leave you feeling discussions may also cover topics such as the importance of overwhelmed and unproductive. Developing techniques to manage identifying mentors and describing the roles and functions of a your time to accomplish what matters is crucial for your success and mentor. This is an excellent opportunity to network with senior ORS

rd S well-being. Creating the team that will help enhance your vision members and ask questions of the mentors in an informal, small A will promote an inspiring and productive environment. How do TU group environment. The Women’s Leadership Forum will host two you organize your time to accomplish what matters? How do you tables for interaction and mentorship with female ORS leaders. promote excellence and inspire your research personnel? From

A time management to lab management strategies, this networking

Y session will provide guidance and advice based on ORS mentors’ own experiences and will focus on staffing (hiring, inspiring and firing), prioritizing and setting career goals, managing your time to maximize efficiency and knowing when to say yes and when to say no. PAPER PRESENTATIONS 12:00 PM – 1:00 PM See page 21 AGENDA 11:00 – 11:05Am Welcome & Introductions Nelly Andawaris-Puri, PhD and Devina Purmessur, PhD NIRA PRESENTATIONS 1:15 PM – 2:15 PM 11:05 – 11:20am See page 22-23 Managing Your Time for Success Larry Bonassar, PhD

11:20 – 11:35am Staffing and Promoting an Inspired Environment Susannah Fritton, PhD

11:35am – 12:00pm Q&A Moderators: Drs. Nelly Andarawis-Puri and Devina Purmessur

18 SATURDAY | PROGRAM DETAILS Saturday, March 28, 2015

ORS/OREF BASIC SCIENCE COURSE Musculoskeletal Tissue Physiology and Function P art I: Saturday March 28, 2:00 PM – 6:00 PM Bone Part II: Sunday, March 29, 8:00 AM – 11:15 AM Karl J. Jepsen, PhD, University of Michigan Room 117 Skeletal Muscle and Nerve Richard L. Lieber, PhD, Rehabilitation Institute of Chicago Organizers: Richard L. Lieber, PhD, Rehabilitation Institute of Chicago Tendon and Ligament Marjolein C. van der Meulen, PhD, Cornell University Louis J. Soslowsky, PhD, University of Pennsylvania Theodore Miclau, MD, Orthopaedic Trauma Institute Cartilage The ORS/OREF Basic Science Course will provide attendees with Suzanne A. Maher, PhD, Hospital for Special Surgery the tools to explain the functions and limitations of the science Meniscus and Intervertebral Disc behind the decisions, treatments, and procedures that are Robert L. Mauck, PhD, University of Pennsylvania performed in practice every day. The course content has been derived from the Orthopaedic Basic Science: Foundations of Clinical Pre-registration required Practice textbook developed in partnership with the AAOS and Residents/Students/Associates: $145; ORS and/or AAOS registrants: ORS. Covered topics will include principles of orthopaedic surgery $195; Non-Members: $295 Y

basic science, musculoskeletal tissue biology, and musculoskeletal A All fees include Orthopaedic Basic Science: Foundations of Clinical pathophysiology. Course attendees will also receive a copy of Practice textbook the textbook as part of the registration fee. The knowledge of

the concepts learned in this course is evaluated through the TU Orthopaedic In-Training Examination and the American Board of A BREAK S rd Orthopaedic Surgery Part I and Recertification Examinations. The course will benefit anyone currently in the field or entering the 2:30 PM – 3:00 PM field of orthopaedics including orthopaedic residents and fellows, Innovation Central/Marquee Ballroom practicing orthopaedic surgeons and musculoskeletal researchers. Visit with exhibitors and view posters in Innovation Central. Refreshments will be served. Part I: Principles of Orthopaedic Surgery Basic Science Welcome and Introduction Richard L. Lieber, PhD, Rehabilitation Institute of Chicago INNOA V TION THEATER PRESENTATION: THINK Surgical Molecular and Cellular Biology Tamara Alliston, PhD, University of CA, San Francisco TCAT™ as a Research Tool Musculoskeletal Development and Genetic Diseases 2:45 PM – 3:00 PM Jennifer Westendorf, PhD, Mayo Clinic Innovation Central/Marquee Ballroom Principles of Biomechanics THINK Surgical, Inc. develops, manufactures, and markets an active Marjolein C. van der Meulen, PhD, Cornell University computer-assisted surgical system for orthopedic surgery and is Orthopaedic Biomaterials committed to the future of orthopedic surgery and to improving Kenneth A. Mann, PhD, SUNY Upstate Medical University patient care through the development of leading-edge precision technology. Learn about the technology and potential research Kinesiology collaborations with THINK. Samuel R. Ward, PhD, University of CA, San Diego

19 SATURDAY | PROGRAM DETAILS Saturday, March 28, 2015

WORKSHOPS tribocorrosion, knowledge gaps that are fertile areas of future research and novel findings that challenge the current paradigms of 3:00 PM – 4:30 PM metal implant biocompatibility. Bioreactivity of Tribocorrosion Debris: Known Unknowns Hot Topics in Regulatory Challenges within Orthopaedics Joshua J. Jacobs, MD, Midwest Orthopaedis at Rush Room 111-112 Histological Correlates of Modular Implant Tribocorrosion Presented by: Patricia A. Campbell, PhD, Orthopaedic Hospital The ORS Corporate Affairs Committee Novel Biological Observations in Modular Implant Tribocorrosion Organizers: Jeremy L. Gilbert, PhD, Syracuse University David W. Schroeder, MBA, Biomet, Inc. Jacob L. Cartner, MS, Smith & Nephew Trials, Tribulations and Triumphs of Conducting Prospective The goal of all regulatory agencies is to have a safe and effective Clinical Research Studies: The How and Why product in the market while not creating an overly burdensome Room 116 environment that stifles innovation. Traditional orthopedic devices rd S are becoming increasingly more interconnected with biological Presented by: A

TU solutions. Therefore, regulatory submissions may be reviewed by The ORS Women’s Leadership Forum different departments under the same regulatory agency, thus Organizers: increasing burden of proof and time for approval. Robin M. Queen, PhD, Duke University A

Y This workshop will focus on the past, present, and future of global Karen King, PhD, University of Colorado at Denver and Health regulatory pathways and associated requirements. It will entail Sciences Center Orthopaedics – Bioengineering how to best navigate new regulatory challenges. Specifically, Moderators: speakers will discuss their own experiences with navigating the FDA when submissions include biological and cell-based products, The logistical challenges of planning and implementing a large considerations for custom or compassionate use devices, and scale clinical research study can be daunting. There are many discussion on the treatment and prevention of infection. Workshop aspects of study design, study implementation, and the study attendees will gain a better understanding of how to approach an team assembly and dynamics that must be considered prior to ever-changing industrial and regulatory landscape. study initiation. This workshop will bring together three scientists who have been highly successful in the planning, funding, and My Experience in Getting a Cell-Based Therapy to Market implementation of large scale clinical studies to explore all aspects Chris Gemmiti, PhD, Ridgewood Consulting LLC of these projects including the trials and triumphs. Custom Products for Use in Orthopaedics Moving from an Idea to a Clinical Trial William M. Mihalko, MD, PhD, Campbell Clinic Orthopaedics Cecilia Rogmark, MD, PhD, Skane University Hospital and Swedish Current Status of Technologies to Hip Arthroplasty Register Treat Periprosthetic Joint Infections Engaging Your Subjects: The Johnston County Osteoarthritis Project Steve M. Kurtz, PhD, Exponent, Inc. Joanne Jordan, MD, MPH, University of North Carolina Regulatory Considerations When Planning a Clinical Trial New Horizon Workshop: ORS/The HIP Society - Biological Gloria L. Matthews, DVM, PhD, Genzyme Corporation Aspects of Modular Implant Tribocorrosion

Room 113 - 114 Quantitative MR Imaging: Organizers: Research Applications and Clinical Translation Harry E. Rubash, MD, Room 118 - 120 Massachusetts General Hospital Mathias P. Bostrom, MD, Organizer: Hospital for Special Surgery Hollis G. Potter, MD, Hospital for Special Surgery Failure of total joint replacement reconstructions due to Quantitative imaging of bone, articular cartilage, meniscus, and tribocorrosion of modular hip replacement components is intervertebral disc and endplate provides noninvasive insight into being observed with increasing frequency in contemporary tissue biochemistry and structure. Basic principles of MR research clinical practice. Much remains to be understood regarding the sequences will be discussed in this workshop, with correlates to pathogenesis of the adverse local tissue reactions associated more traditional imaging methodologies. The application of these with modular implant tribocorrosion. This workshop will focus techniques to translational clinical application will be discussed. on the current understanding of the cell and tissue response to

20 SATURDAY | PROGRAM DETAILS Saturday, March 28, 2015

Quantitative Imaging of Bone Sharmila Majumdar, PhD, University of California, San Francisco WELCOME SESSION Quantitative Imaging of the Intervertebral Disc and Endplate Won C. Bae, PhD, University of California, San Diego 4:45 PM – 5:45 PM Room 118 – 120 Quantitative MRI of the Meniscus Matthew F. Koff, PhD, Hospital for Special Surgery ORS Guest Nation – PROFESSIONAL ADVANCEMENT SESSION Japan and the Japanese Orthopaedic Association C areer Advancement: Winning the Uphill Battle for Research Funding Professor Yukihide Iwamoto, 3:00 PM - 4:30 PM MD, President, Japanese Orthopaedic Association Room 121-122 Organizer:

ORS New Investigator Mentoring Committee Y A Moderator: Jinxi Wang, MD, PhD, University of Kansas Medical Center

Acquiring funding for research is more competitive than ever. Budget TU A cuts have been a threat to individual researchers and research S rd Pamela Schroeder, programs that affect musculoskeletal basic scientists and physician scientists at all stages. Whether you are a postdoctoral fellow, new Patient Advocate investigator, mid-career investigator, or established investigator, this I have been a dedicated advocate Professional Advancement Session will provide you with the tools for Orthopaedic surgery and the to meet these challenges and to streamline career advancement advancement in musculoskeletal strategies in today’s competitive funding environment. research. I have served on This PAS includes brief presentations and ample discussions with The American Academy of the panel members who have experience with research grant policy, Orthopaedic Surgeons Patient submission, review process, and post-award management. Topics Advisory Board for five years and include: What to do when you submit but don’t get funded; What I have advocated on Capitol Hill to do when you submit and do get funded; What to do if you are for musculoskeletal research stuck after completing a small grant project; What to do if your grant funding. I spend free time talking is not renewed as you expected; What to do if your tenure review is to patients considering knee and ankle replacements. I am approaching but your NIH grant application is still pending. eternally grateful to have been given this opportunity to say thank you to The Orthopaedic Research Society, without Panel members: all of you I would not be where I am today. Thank you for Henry Donahue PhD, Penn State University College of Medicine, PA making a difference in my life and the lives of millions. James Iatridis PhD, Icahn School of Medicine at Mount Sinai, NY Lynn Snyder-Mackler PT, ScD, FAPTA, STAR University of Delaware, DE Melissa Marshall, ORS Presidential Guest Speaker Mary Goldring PhD, Hospital for Special Surgery and Weill Cornell Medical College, NY “Science Not Communicated is Science Not Done” Gayle Lester PhD, NIH/NIAMS Program Director Important research often does not move forward becausethe significance of that research is not understood and appreciated by others. Melissa Marshall’s will motivate listeners on the importance of communication to the success and advancement of their research. She will explore how effective communication is the linchpin between research and those that are in a position to advance that research.

21 SATURDAY | PROGRAM DETAILS Saturday, March 28, 2015

ORS PRESIDENT’S WELCOME RECEPTION 6:00 PM – 8: 00 PM Innovation Central/Marquee Ballroom Don’t miss the excitement of the ORS Annual Meeting’s largest social event! Enjoy food and drinks while meeting new people and catching up with old friends and colleagues. All ORS Meeting Attendees are welcome to attend this kick-off reception.

Registered meeting attendees will receive 2 drink tickets for this event. Guests can register to attend the receptions. Please visit the Registration Desk for more information. rd S A TU A Y

22 SATURDAY | Sessions 12:00PM–1:00PM Saturday, March 28, 2015

Time Session 1 Session 2 Session 3 Spotlight SESSION 4 spotlight Session 5 Bone Disease Knee Kinematics Hip Disease, Advanced Articular Intervertebral Disc: and Gait Kinematics, FAI Cartilage Imaging Degeneration, Pain and Techniques Treatment

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Edward M. Schwarz, PhD and Kang Li, PhD and John J. Fang (Amanda) Lin, DSc, Matthew F. Koff, PhD and Daisuke Sakai, MD, PhD and Joseph Wallace, PhD Elias, PhD MMed, BEng and Yupeng Won C. Bae, PhD Lachalan Smith, PhD Chen, PhD

12:00 PM Paper No. 0001 Paper No. 0007 Paper No. 0013 Paper No. 0019 Spotlight Speaker Paget`s Disease Of Bone-like Effect of Unstable Meniscal Effects of Acetabular Rim Comparison Of Annual Changes In Howard S. An, MD Disorder Is Caused By Chmp5 Injury on Three-dimensional Trimming on the Hip Joint Contact Knee Articular Cartilage Thickness Deletion And Reversed By The Knee Kinematics in ACL-deficient Pressure: How Much is Too Much? Between The Osteoarthritis Treatment Of OPG-Fc Patients During Gait Sanjeev Bhatia, Simon Lee, Elizabeth Side And The Contra-lateral Kwang Hwan Park, Matthew B Kengo Harato, Yasuo Niki, Aiko Shewman, Michael J Salata, Charles A Side Measured By B-mode Greenblatt, Jae-Hyuck Shim, Jae Myun Sakurai, Yutaka Kudo, Takeo Nagura, Bush-Joseph, Shane J Nho Ultrasonography With Mechanical Lee, Jin Woo Lee Ko Masumoto, Toshiro Otani, Yoshiaki 3d Scanning In Osteoarthritis Toyama, Yasunori Suda Patients Satoru Ohashi, Takumi Nakagawa, Shuji Taketomi, Hiroshi Inui, Kumiko Ono, Hiroyuki Oka, Kozo Nakamura, Sakae Tanaka Y

12:10 PM Paper No. 0002 Paper No. 0008 Paper No. 0014 Paper No. 0020 A Moderate Chronic Kidney Disease The Effect of Cruciate Preservation Three-dimensional Measurement Deep Imaging of Collagen- and Impairs Bone Quality in Skeletally on Walking Base of Support Of The Muscle Volume And The Proteoglycan-Rich Tissues using Mature C57Bl/6 Mice Fatty Degeneration Of The Gluteus Optical Clearing Ruaraidh Collins, Gareth Jones, Victoria TU Medius In Patients With Hip Strategies for Treating Chelsea Heveran, Alicia Ortega, Andrew Manning, Justin Cobb Corey Neu, Tyler Novak, Kateri Gilliland, A Osteoarthritis Intervertebral Disc Degeneration: Cureton, Eric Livingston, Ted Bateman, Peter Marshall, Sarah Calve Matrix Restoration or Pain Relief? S rd Moshe Levi, Karen B King, Virginia Takako Momose, Yutaka Inaba, Naomi Ferguson Kobayashi, Hiroyuki Ike, Taro Tezuka, So Kubota, Tomoyuki Saito

12:20 PM Paper No. 0003 Paper No. 0009 Paper No. 0015 Paper No. 0021 Increased Ckip-1 Expression Influence of Anatomy on Dynamic Statistical Shape Modeling to Relationship between T1ρ MRI in And Decreased Phosphorylated Tracking in Patellar Instability Quantify and Comparison of Cartilage of Non-Osteoarthritic Smad1/5 Within Osteoblasts John J Elias, Neil T Soehnlen, Loredana Proximal Femoral Cortical Bone Knees With and Without Posterior During Bone Formation Reduction M Guseila, William A Wilson, John A Thickness between Patients with Meniscus Lesions In Glucocorticoid-induced Carrino, Andrew J Cosgarea Femoroacetabular Impingement Nathaniel E Calixto, Deepak Kumar, Osteoporotic Rats and Normal Hips Analyzed by Karupppasamy Subburaj, Justin Singh, Changwei Lv, Jin Liu, Baosheng Guo, Statistical Shape Modeling Joseph Schooler, Lorenzo Nardo, Defang Li, Chao Liang, Baoting Zhang, Penny Atkins, Prateep Mukherjee, Xiaojuan Li, Richard B Souza, Thomas Xiaohua Pan, Lingqiang Zhang, Aiping Shireen Elhabian, Sumedha Singla, M Link, Sharmila Majumdar Lu, Ge Zhang Michael Harris, Jeffrey A Weiss, Ross Whitaker, Andrew Anderson

12:30 PM Paper No. 0004 Paper No. 0010 Paper No. 0016 Spotlight Speaker Paper No. 0022 Study Of Pain-related Behavior And In-vivo Kinematics of the Knee 3 A Novel Model For The Induction Carl Winalski, MD Responses Of Intervertebral Disc Immunohistochemical Analysis In Years after ACL Reconstruction Of Hip Dysplasia In The Developing Cells To A Degenerative Tissue The Hindlimb-unloaded Mice Model Jing-Sheng Li, Ali Hosseini, Chunbao Murine Hip Environment Of Bone Loss LI, Felix Yang, Amit Chawla, Thomas J Megan Leigh Killian, Michael G James, Vivian Tam, Anita Yee, Rakesh Sharma, Taro Nakagawa, Hiroki Wakabayashi, Gill, Guoan Li Stavros Thomopoulos, John C Clohisy Kenneth Cheung, Kathryn Cheah, Yun Yohei Naito, Sho Kato, Takahiro Iino, Wah Lam, Danny Chan Akihiro Sudo

12:40 PM Paper No. 0005 Paper No. 0011 Paper No. 0017 Paper No. 0023 Combination Sclerostin Antibody Changes in Macrophage Decreased Relationships between Severity Systemic Biomarker Profiles in and Zoledronic Acid Treatment Dynamic Knee Joint Stiffness in of Deformity and Impingement Subjects with Low Back Pain Differ Outperforms Either Treatment Patients with Knee Osteoarthritis in Acute Slipped Capital Femoral in Patients Treated Surgically Alone in a Mouse Model of and Complaints of Instability Epiphysis versus with Pain Management. Osteogenesis Imperfecta Jonathan A Gustafson, G. Kelley Carly E Jones, Agnes G d’Entremont, Kathryn T Weber, Didier O Alipui, David G Little, Lauren Peacock, Kathy Fitzgerald, Shawn Farrokhi Anthony P Cooper, Jonathan Doucette, Shina Satoh, Angelos Papatheodorou, Mikulec, Michaela Kneissel, Ina Kramer, Lawrence L Buchan, David R Wilson, Karen Black, Peter Hollis, Chris Overby, Tegan Cheng, Aaron Schindeler, Craig Kishore Mulpuri Imaging Approaches to Articular Shaheda Quraishi, Ona Bloom, Mitchell Munns Cartilage Evaluation Levine, Nadeen O. Chahine

12:50 PM Paper No. 0006 Paper No. 0012 Paper No. 0018 Paper No. 0024 Loss of TIEG and Decreases in Relationship of Biomechanical Hip Joint Stresses in Individuals Reactive Oxygen Species Wnt Signaling are Substantially and EMG Factors to Joint Contact with an Asymptomatic Cam Are Therapeutic Targets For Abrogated by Sclerostin Antibody Forces and Early Knee OA after ACL Deformity during Level-Walking Intervertebral Disc Degeneration Therapy which Elicits a Robust Reconstruction Geoffrey Ng, Giulia Mantovani, Mario Satoshi Suzuki, Nobuyuki Fujita, Skeletal Response Elizabeth Wellsandt, Ashutosh Lamontagne, Michel R Labrosse, Paul Naobumi Hosogane, Ken Ishii, Ryuichi Anne Gingery, Kevin Pitel, Gino Gaddini, Khandha, Kurt Manal, Michael Axe, E Beaule Watanabe, Tomohiro Hikata, Keiyo Xiaodong Li, Ke Hua, Urszula Iwaniec, Thomas Buchanan, Lynn Snyder- Takubo, Kota Watanabe, Keisuke Russell Turner, Thomas Spelsberg, Mackler Horiuchi, Yoshiaki Toyama, Takeshi Malayannan Subramaniam, John Hawse Miyamoto, Morio Matsumoto

23 SATURDAY | NIRA Sessions 1:15PM–2:15PM Saturday, March 28, 2015

Time NIRA PRESENTATION 6 NIRA PRESENTATION 7 NIRA PRESENTATION 8 Bone Biology & Repair Joint Physiology & Mechanics Cell Differentiation Fibrosis & CancerI

Room # 111-112 Room # 113-114 Room # 116

Moderators Andrea I. Alford, PhD and Edward Purdue, PhD Nico Verdonschot, PhD and Kenneth A. Mann, PhD Douglas D. Robertson, Jr., MD, PhD and Brian Snyder, MD, PhD

1:15 PM Paper No. 0025 Paper No. 0033 Paper No. 0041 SDF-1/CXCR4 Axis in Tie2-lineage Cells Including Endothelial Orthopaedic Grade Cobalt Chromium Alloy Particle Corrosion Distinct Patterns Of 5hmC Acquisition Mark Chondrogenic Progenitor Cells Regulates Bone Fracture Healing and Biological Evaluation Differentiation Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Tomoya Kuroda, Danielle de Villiers, Agata Nyga, Terry Tetley, Akramul Hoque, Alister Sarah E. B. Taylor, Ye Henry Li, Piera Smeriglio, Madhusikta Rath, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Takayuki Asahara, Masahiro Hart, Julia C Shelton Wing H Wong, Nidhi Bhutani Kurosaka

1:22 PM Paper No. 0026 Paper No. 0034 Paper No. 0042 Collagen-Based Bone Sialoprotein Implants Promote Cranial Early Phase of Wear Particle Induced Inflammation was Human Mesenchymal Stem Cell and Endothelial Cell Bone Repair by Stimulating Osteoblastic Differentiation of inhibited by NF-κB Decoy Oligodeoxynucleotide Interaction through Endothelin-1 Dura-Derived Osteoprogenitor Cells Taishi Sato, Jukka Pajarinen, Tzu-hua Lin, Florence Loi, Kensuke Tsung-Lin Tsai, Bowen Wang, Matthew Squire, Lian-Wang Guo, Paul C. Cowan, Yan Wang, Qinghua Lu, John G. Yost, Yi Feng, Andrew Egashira, Zhenyu Yao, Stuart B Goodman Wan-Ju Li H. Miller, Jinxi Wang rd S

A 1:29 PM Paper No. 0027 Paper No. 0035 Paper No. 0043 TU Identification of a Novel Regulatory Mechanism underlying Gender Differences in Knee Laxity and Stiffness: AnI n Vitro Ex-vivo Gene Therapy-induced Cartilage Regeneration: PTH Anabolic Action on Bone Mass and Injury Repair via Study of Age Matched Specimens from a Younger Population Comparison of Different Subpopulations of Primary Muscle- Induction of Tob Required for RANKL Expression Daniel Boguszewski, Edward Cheung, Nirav Joshi, Keith Markolf, Derived Cells

A Shuichi Moriya, Yoichi Ezura, Tadayoshi Hayata, Yayoi Izu, Kazuo David McAllister Hongshuai Li, Aiping Lu, Ying Tang, MaCalus V Hogan, Johnny Huard

Y Kaneko, Masaki Noda

1:36 PM Paper No. 0028 Paper No. 0036 Paper No. 0044 Organ Culture Based Real-time Luminescence Imaging Molecular Characteristics Proving Femoroacetabular Inhibitory Effect of Photodynamic Therapy with a Novel Revealed The Circadian Clock Exists In A Fracture Healing Site Impingement As The Precursor To Hip Osteoarthritis Indocyanine Green-labeled Nanoparticle and Near-infrared Of A Mouse Femur. Nobuaki Chinzei, Shingo Hashimoto, Takaaki Fujishiro, Shinya Light on the Growth of Bone Metastasis of a Human Breast Tatsuya Kunimoto, Hiroyoshi Fujiwara, Naoki Okubo, Yoichi Minami, Hayashi, Noriyuki Kanzaki, Masahisa Hatakeyama, Shuhei Sakata, Cancer in vivo Toshihiro Hosokawa, Ryo Oda, Toshikazu Kubo, Kazuhiro Yagita Shinsuke Kihara, Katsuhiko Haneda, Soshi Uchida, Ryosuke Kuroda, Toshinori Tsukanishi, Masataka Sakane, Tetsuya Abe, Toru Funayama, Masahiro Kurosaka Shinzo Onishi, Eiichi Ozeki, Isao Hara, Masashi Yamazaki

1:43 PM Paper No. 0029 Paper No. 0037 Paper No. 0045 MT1-MMP Mediates Plasticity and Divergence of the Sex Differences in Knee Cartilage Pressure Distribution RPN2 Gene Confers Osteosarcoma Lethal Phenotypes and Osteoblast and Adipocyte Lineages Through Cleavage of DLK1 Under Functional Loading Conditions: Implications for Knee Determines Clinical Prognosis Jason A Horton, Heba Degheidy, Teresa Yang, Nozomi Sakakibara, Osteoarthritis Risk Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Yutaka Nezu, Aki Steven R Bauer, Pamela G Robey, Kenn Holmbeck Ata M Kiapour, Carmen E Quatman, Samuel C Wordeman, Vijay K Yoshida, Koji Uotani, Kazuhisa Sugiu, Toshiki Omori, Takehiro Uehara, Goel, Timothy E Hewett, Constantine K Demetropoulos Yasuaki Yamakawa, Akira Kawai, Takahiro Ochiya, Toshifumi Ozaki

1:50 PM Paper No. 0030 Paper No. 0038 Paper No. 0046 Aptamer-Functionalized Delivery System for Osteogenic Estimation Of Optimal Shoulder Orientation During The Oral Administration of Losartan significantlyI mproves siRNAs to Achieve Osteoblast-Specific RNA Interference for Acceleration Phase In Baseball Pitching From Minimal Muscle Healing after Compartment Syndrome-Like Muscle Bone Anabolic Therapy Shoulder Joint Load Viewpoint Injury Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Hiroshi Tanaka, Toyohiko Hayashi, Hiroaki Inui, Yohei Takagi, Takanori Makoto Kobayashi, Yohei Kawakami, Takanobu Otsuka, Freddie H. Ge Zhang Oi, Katsuya Nobuhara Fu, Johnny Huard

1:57 PM Paper No. 0031 Paper No. 0039 Paper No. 0047 Macrophage-associated Osteoactivin/gpnmb Mediates Validation of MRI Quantification for Meniscus Volume κv Integrin Depletion Inhibits Profibrotic Cell Activation And Mesenchymal Stem Cell Survival, Proliferation and Migration Resection Following Partial Meniscectomy Skeletal Muscle Fibrosis via a CD44-dependent Mechanism Shiree Segev, Brian T Feeley, Sharmila Majumdar, Richard B. Souza Iain R Murray, Zaniah Gonzalez, John Iredale, Hamish Simpson, Bruno Bing Yu, Gregory Sondag, Christopher Malcuit, Min-Ho Kim, Fayez Peault, Neil Henderson F Safadi

2:04 PM Paper No. 0032 Paper No. 0040 Paper No. 0048 Therapeutic Inhibition Of Mir-214 By (asp-ser-ser)6-liposome Identification Of An Evolutionarily Conserved Host Response The Effect of Continuous and Local IL-4 Delivery on Systemic Encapsulating Antagomir-214 In Osteogenic Cells For Against IsdA And IsdB As A Virulence Factor Associated Macrophage Trafficking and Polyethylene ParticleI nduced Promoting Bone Formation In Aged Osteoporotic Rats With Death In Patients With Staphylococcus aureus Bone Loss Baosheng Guo, Aiping Lu, Baoting Zhang, Ge Zhang Musculoskeletal Infections Jukka Pajarinen, Taishi Sato, Tzu-hua Lin, Florence Loi, Ruth Zhang, Kohei Nishitani, Alexander F Rosenberg, Christopher A Beck, Hiromu Changchun Fan, Zhenyu Yao, Stuart B Goodman Ito, Stephen L Kates, John L Daiss, Edward M. Schwarz

24 SATURDAY | NIRA Sessions 1:15PM–2:15PM Saturday, March 28, 2015

Time NIRA PRESENTATION 9 NIRA PRESENTATION 10 OA & Cartilage Stem Cells & Tissue Repair

Room # 118-120 Room # 121-122

Moderators Susanna G. Chubinskaya, PhD and Anne-Marie Malfait, MD, PhD Johnny Huard, PhD and Vicki Rosen, PhD

1:15 PM Paper No. 0049 Paper No. 0057 Mechanotransduction in Articular Chondrocytes: High-Strain Activates Piezo1 and Piezo2 Wnt5a Treatment Of Embryonic Stem Cell Progenitors Promotes Cartilage Repair In A Rat Channels Chondral Defect Model W. Lee, H. A. Leddy, Y. Chen, S. Lee, N. Zelenski, A. L. McNulty, J. Coles, J. Grandl, S. Zauscher, F. Sachs, W. Jason D Gibson, Farhang Alaee, David N. Paglia, Ryu Yoshida, Thomas DeBerardino, Rosa Guzzo, Hicham Liedtke, F. Guilak Drissi

1:22 PM Paper No. 0050 Paper No. 0058 Protective Mechanism Adopted by Chondrocytes through Unfolding of Surface Ruffles during TGFβ1 Signalling in Human Mesenchymal Stem Cells is regulated by the Primary Cilium Mechanical Compression Marie-Noelle Labour, David Hoey Eng Kuan Moo, Walter Herzog

1:29 PM Paper No. 0051 Paper No. 0059 Y A Feasibility and Reproducibility of a Displacement Controlled MRI-Compatible Loading Device Intervertebral Disc Regeneration Using Mesenchymal Stem/Stromal Cells Transplanted Via for Assessing Knee Articular Cartilage Deformation in Human Knees The End-Plate Route in a Large Animal Model Hongsheng Wang, Matthew F Koff, Hollis Potter, Russell Warren, Scott Rodeo, Suzanne Maher Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Francesca De Strobel, Marco Bernardini, Giulia De Benedictis, Luca Denaro, Domenico D’Avella, Rosaria Giordano, Vincenzo Denaro TU A S rd 1:36 PM Paper No. 0052 Paper No. 0060 Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in Synovial Mesenchymal Stem Cells Enhance Healing of Meniscal Repair In The Avascular Zone the Synovial Fluid of Longitudinal Tear Using A Pig. Ryosuke Yamaguchi, Nobuhiro Kamiya, Naga Suresh Adapala, Elena Chen, David Neal, Hicham M Drissi, Yusuke Nakagawa, Takeshi Muneta, Shimpei Kondo, Masafumi Horie, Hideyuki Koga, Ichiro Sekiya Harry Kim

1:43 PM Paper No. 0053 Paper No. 0061 Bone Marrow Stimulation Technique Augmented By Ultrapurified Alginate Gel Enhances Total Disc Replacement Using Tissue Engineered Intervertebral Discs In An In-vivo Beagle Osteochondral Repair In A Rabbit Osteochondral Defect Model Model Rikiya Baba, Tomohiro Onodera, Daisuke Momma, Masatake Matsuoka, Kazutoshi Hontani, Norimasa Yu Moriguchi, Rodrigo Navarro, Peter Grunert, Jorge Mojica, Katherine Hudson, Thamina Khair, Marjan Iwasaki Alimi, Lawrence Bonassar, Roger Hartl

1:50 PM Paper No. 0054 Paper No. 0062 Administrations Of Tenascin-c Delay Cartilage Degeneration In Murine Models Of Osteoarthritis The Role of Prostanoid Receptor EP4 on Adhesion Formation in Flexor Tendon Healing - Hironori Unno, Masahiro Hasegawa, Yuriyo Matsui, Yoshiaki Suzuki, Takahiro Iino, Toshimichi Yoshida, Differential Effects of Tendon-Specific Deletion Versus Systemic Antagonism Akihiro Sudo Michael B Geary, Caitlin Orner, Fatima Bawany, Warren C Hammert, Regis J O’Keefe, Alayna E Loiselle

1:57 PM Paper No. 0055 Paper No. 0063 Endogenous Stores of Latent TGF-β Serve to Maintain the Integrity and Viability of Articular The Role of Hedgehog Signaling in Enthesis Healing Cartilage Over Long Term Culture in Response to Physiologic and Excessive Dynamic Mechanical Andrea G Schwartz, Leesa M Galatz, Stavros Thomopoulos Loading Michael B Albro, Krista M Durney, Jay J Shim, Akaljot Singh, Gerard A Ateshian, Molly M Stevens

2:04 PM Paper No. 0056 Paper No. 0064 The Synovial Lymphatic System Plays a Critical Role in the Pathogenesis of Osteoarthritis Human, Muscle-derived Induced Pluripotent Stem Cells Loaded Onto Coral Scaffolds Are Hao Xu, Wensheng Wang, Echoe Bouta, Ronald Wood, Hengwei Zhang, Edward M. Schwarz, Micheal Zuscik, Osteoinductive In An Ectopic Mouse Model Yongjun Wang, Lianping Xing Karim Oudina, Joseph Paquet, Emmanuelle Massourides, Morad Bensidhoum, Nathanael Larochette, Peter Upex, Mickael Deschepper, Delphine Logeart, Christian Pinset, Herve Petite

25 SUND AY | meeting highlights Sunday, March 29, 2015

m 8:00a -11:15am m 10:30a -11:00am m 1:30P -1:45Pm

ORS/OREF Basic Science Course: Part II* Refreshment Break I nnovation Theater Presentation: Room 117 Innovation Central/Marquee Ballroom AMTI RefiningS imulation in a Bio-fedelic Testing Environment m 8:00a -9:00am m 10:45a -11:00am Innovation Central/Marquee Ballroom

Sessions I nnovation Theater Presentation: m 2:00P -3:30Pm Micro Photonics Biomaterials for Bone Repair Advancements in Nano-Computed Room 111-112 Tomography for Orthopedic Applications Workshops Innovation Central/Marquee Ballroom Knee - Mechanics ORS/OTA - Systemic Inflammation Room 113-114 and Organ Dysfunction 11:15Am-12:30Pm in Multiply Injured Patients Bone Necrosis New Horizon Workshop Spotlight Session Room 113 - 114 Room 116 Kappa Delta, OREF, CORR®

SUND ORS Award Paper Presentations ORS/SOMOS - How an Integrated Pain Pathways and Therapies Room 118 - 120 Orthosis and Rehabilitation Initiative in Experimental OA has Improved Outcomes for Lower Spotlight Session

A Extremity Limb Salvage Patients Y Room 118 - 120 m 12:45P -1:45Pm Room 111 - 112

Tendon/Ligament Cell Biology Improving the Translational Success Room 121-122 P oster Walking Tours of Cell-Based Therapies Marquee Ballroom Room 118 – 120

m 9:00a -6:00Pm New Investigator Networking Session: Professional Advancement Session: An Inside Look at Research Funding Finding a Partner in Research Opportunities with the National Room 121 - 122 P oster and Exhibit Hall Open Institutes of Health (NIH) Innovation Central/Marquee Ballroom Room 115 m 3:45P -4:45Pm ORS Translational Research Symposium: m 9:15a -10:15Am Cartilage Repair: Is it Possible? Room 121-122 OUT Sessions Sessions Diagnostic Imaging: SOLD m 12:45P -5:00Pm From Spine to Cartilage Osteoblasts/Progenitor Cells Room 111 - 112 Room 111 - 112 ORS Clinical Research Forum- Total Hip & Knee Replacement: Total Hip Replacement The Basis for Clinical Decision Making Clinical Perspectives and Biomechanics Metal Wear Reactions in Orthopaedics Room 113 - 114 Room 113 – 114 Room 116 PTOA: Studies in Preclinical Models Imaging and Bone Healing Spotlight Session Spotlight Session m 1:00P -1:15Pm Room 118 - 120 Room 116 Spine Therapeutics Knee OA Repair I nnovation Theater Presentation: Room 121 – 122 Spotlight Session National Disease Research Room 118-120 Interchange (NDRI) Project-driven Human Biospecimen Tendon/Ligament - Service for Biomedical Research Repair and Tissue Engineering Innovation Central/Marquee Ballroom 26 Room 121 – 122 SUNDAY | meeting highlights CONT. Sunday, March 29, 2015

m 4:45P -6:00Pm m 7:00P -10:00Pm

P oster Reception I (authors present) ORS Awards Gala Reception and Dinner Innovation Central/Marquee Ballroom Vista Ballroom

SUND AY | PROGRAM DETAILS

PAPER PRESENTATIONS PAPER PRESENTATIONS 8:00 AM – 9:00 AM 9:15 AM – 10:15 AM Y

See page 32 See page 33 A SUND ORS/OREF BASIC SCIENCE COURSE PART II* BREAK 8:00 AM – 11:15 AM (Continued from Saturday, See page 17) 10:30 AM – 11:00 AM Room 117 Innovation Central/Marquee Ballroom Part II: Musculoskeletal Pathophysiology Visit with exhibitors and view posters in Innovation Central. Tissue Engineering in Orthopaedics Refreshments will be served. Michael J Yaszemski, MD, PhD, Mayo Medical Center Bone Injury, Regeneration and Repair INNOA V TION THEATER PRESENTATION: Ralph Marcucio, PhD, University of CA, San Francisco Micro Photonics Molecular Basis of Cancer Advancements in Nano-Computed Tomography R Lor Randall, MD, University of Utah, Huntsman Cancer Institute for Orthopedic Applications Orthopaedic Infections Joseph C. Wenke, PhD, US Army Institute of Surgical Research 10:45 AM - 11:00 AM Inflammation in the Musculoskeletal System Innovation Central/Marquee Ballroom Regis J O’Keefe, MD, Washington University, St. Louis Learn how you can achieve unprecedented levels of clarity in Osteoporosis/Metabolic Bone bone-metal interfaces, obtain a high degree of accuracy in low Susan V Bukata, MD, University of CA, Los Angeles density polymer scaffold images, and resolve submicron features in bone regeneration models. The new SkyScan 2211 brings you Post-Traumatic Osteoarthritis cutting-edge technology by combining nano and macro scale William Bugbee, MD, Scripps Clinic computer tomography in a single unit. Implant Wear and Inflammatory Response Darryl D D’Lima, MD, PhD, Scripps Clinic Thromboembolic Disease and Fat Embolism Syndrome Vincent D. Pellegrini, Jr., MD, Medical University of South Carolina Pre-registration required Residents/Students/Associates: $145; ORS and/or AAOS registrants: $195; Non-Members: $295 All fees include: Orthopaedic Basic Science: Foundations of Clinical Practice textbook 27 SUND AY | PROGRAM DETAILS Sunday, March 29, 2015

GENERAL SESSION POSTER WALKING TOURS Kappa Delta, Orthopaedic Research & Education 12:45 PM – 1:45 PM Foundation, and CORR®/ORS Richard A. Brand Award Innovation Central/Marquee Ballroom for Outstanding Orthopaedic Research Paper Presentations 11:15 AM - 12:30 PM Poster Walking Tours Poster Session I Tours will feature posters in the following topics: Room 118 - 120 (Authors may be present.)

Robert L. Mauck, PhD, recipient of the Biomaterials – Posters 0273, 0285 and 0286 2015 Kappa Delta Young Bone Biology – Posters 0537, 0572, 0574 and 0589 Investigator Award Bone Fracture – Posters 0633 and 0642 Cancer/Tumors – Posters 1060 and 1069 Engineering Dense Connective Cartilage, Synovium & Osteoarthritis – Poster 0435 Tissues: Mechanical, Material, and Diagnostic Imaging – Posters 1114 and 1119 Mechanobiologic Considerations Hip and Knee Arthroplasty – Posters 0869 and 0970 Infection – Posters 1044 and 1045 Knee – Posters 0763, 0802 and 0811 Meniscus – Poster 0459 Steven A. Olson, MD, recipient of the 2015 Muscle – Posters 0521, 0522 and 0523 Kappa Delta Ann Doner Vaughn Award Spine – Poster 0759

SUND Tendon/Ligament – Poster 0500 Early Inhibition of Proinflammatory Cytokines Prevents Post-Traumatic Tours are subject to change. Check sign-up board in

A Arthritis: Insights from the Natural Marquee Ballroom for confirmation of tours.

Y History of Arthritis Developing after Intra-Articular Fracture

NEW INVESTIGATOR NETWORKING SESSION William D. Bugbee, MD, recipient of the An Inside Look at Research Funding Opportunities with the 2015 Kappa Delta Elizabeth Winston National Institutes of Health (NIH)* Lanier Award 12:45 PM -1:45 PM Osteochondral Allograft Transplantation in Cartilage Repair: Graft Storage Room 115 Paradigm, Translational Models, Organizers: and Clinical Applications The New Investigator Mentoring Committee Moderators: Jinxi Wang, MD, PhD Stuart Weinstein, MD, recipient of the Diana Glaser, PhD 2015 OREF Clinical Research Award This NIH Networking Session will provide ORS meeting attendees The Evidence Base for the Prognosis with an opportunity to better understand NIH funding policy and Treatment of Adolescent through one-on-one personal interactions with NIH staff. This Idiopathic Scoliosis session will allow you to ask specific questions and participate in small group discussions with NIH grant review administrators and program officers. Get your questions answered and learn what funding opportunities are available and which grant mechanisms are right for you. The workshop will include representatives from NIAMS, NIA, NIDCR and NIH-CSR. Edward M. Schwarz, MD, recipient of the CORR® ORS Richard A. Brand Award for Outstanding Orthopaedic Research A Multiplex Assay of Host Immunity against S. aureus for Osteomyelitis Patients

28 SUND AY | PROGRAM DETAILS Sunday, March 29, 2015

ORS TRANSLATIONAL RESEARCH SYMPOSIUM Sources of Uncertainty in Randomized Controlled Studies Cartilage Repair: Is it Possible? Roy K. Aaron, MD, Warren Alpert Medical School of Brown University 12:45 PM – 1:45 PM Changing Federal Regulations for Clinical Research Jennifer Racine, MBA, Warren Alpert Medical School of Brown Room 121-122 OUT University Organizer: TheSOLD ORS New Initiatives Committee Session II: Comparative Effectiveness Research Moderator: Moderator: Kristy Weber, MD, University of Pennsylvania George R. Dodge, PhD What is Comparative Effectiveness Research? This innovative program brings together James O. Sanders, MD, University of Rochester speakers to present different views on the topic while inspiring attendees to continue A Practical Approach to Determining Effectiveness in Treating Hip the discussion and apply new ideas to their and Knee Arthritis own research. This year, the topic of cartilage David S. Jevsevar, MD, Intermountain Zion Orthopaedics repair will be discussed from the point of view & Sports Medicine of an orthopaedic surgeon and a bioengineer. From Gaps in Knowledge to Translation of Effectiveness to Patients Both presentations will focus on innovative with ACL Injuries approaches to this perplexing clinical problem. Kevin G. Shea, MD, St. Luke’s Clinic A Physician-Scientist’s Prospective: 25 Years of Clinical Effort Session III: Economic Analysis

Kevin R. Stone, MD, Moderators: Saam Morshed, MD, University of California and Kurt Y The Stone Clinic (Above) Spindler, MD, Cleveland Clinic Foundation A Cracking the Defining Effectiveness Evaluation, Comparative Effectiveness and Cartilage Conumdrum: Economic Analysis of Clinical Literature and Practice SUND A Bioengineer’s View James Slover, MD, MS, NYU Hospital for Joint Diseases Gordana Vunjak-Novakovic, PhD, Columbia University (Below) Basic and Definitions Amy M. Cizik, MPH, University of Washington Putting it All Together – the MOON experience Richard C. Mather, MD, Duke University ORS Clinical Research Forum: T he Basis for Clinical Decision Making in Orthopaedics 12:45 PM – 5:00 PM INNOA V TION THEATER PRESENTATION: Room 116 National Disease Research Interchange (NDRI) Organizer: Project-driven Human Biospecimen The ORS Clinical Research Committee Service for Biomedical Research Kurt Spindler, MD, Chair 1:00 PM – 1:15 PM The ORS Clinical Research Forum will bring together key clinical research leaders to discuss the design, evaluation and reporting Innovation Central/Marquee Ballroom of clinical studies. Furthermore they will discuss comparative The National Disease Research Interchange (NDRI) is a 501(c)(3) effectiveness research and explore the emerging field of economic not-for-profit, NIH-funded organization that provides project-driven analysis. human biospecimen service to academic and corporate scientists. NDRI has over 30 years of experience internationally distributing Session I: Design, Evaluation, and Reporting of Clinical Studies anatomical structures, organs, and tissues for biomedical research. Moderator: Roy K. Aaron, MD, The Warren Alpert Medical School Please by stop to discuss how our programs can help advance your of Brown University research. Principals of Observational Studies Kurt P. Spindler, MD, Cleveland Clinic Foundation Design, Strengths, and Limitations of Observational Trials Morgan H. Jones, MD, MPH Cleveland Clinic for Sports Health Structure of Randomized, Controlled Studies Marc F. Swiontkowski, MD, University of Minnesota Medical Center

29 SUND AY | PROGRAM DETAILS Sunday, March 29, 2015

INNOA V TION THEATER PRESENTATION: ORS/SOMOS - How an Integrated Orthosis and Rehabilitation Initiative has Improved Outcomes for Lower AMTI Extremity Limb Salvage Patients Refining Simulation in a Bio-fedelic Room 111 - 112 Testing Environment Organizers: 1:30 PM – 1:45 PM Daniel J. Stinner, MD, United States Army Innovation Central/Marquee Ballroom Benjamin K. Potter, MD, Walter Reed National Military Medical Center The past decade has seen a shift in the type of failure modes and thus an evolvement of the functional evaluation of prosthetic High-energy lower extremity trauma is common during military designs. True simulation of the complexity of the surrounding combat. Only recently have studies began to evaluate the joint tissues, kinematics and kinetics relevant to the patient, is the outcomes of those service members who have chosen a limb focus of this presentation. We will be highlighting the importance salvage instead of an amputation. A custom energy-storing ankle- of testing joint implants in a more bio-fidelic environment and foot orthosis (Intrepid Dynamic Exoskeletal Orthosis, IDEO) was how this will set the testing benchmark for potential failure modes developed at our institution to be used in conjunction with a high- improving the implant’s function and durability. intensity rehabilitation program (Return to Run Clinical Pathway, RTR) designed to return injured service members to pre-injury, high- level physical activities. The purpose of this workshop is to highlight the outcomes, future research directives, and clinical applications of WORKSHOPS the IDEO and RTR. Multiple research studies have been conducted to evaluate the effectiveness of the IDEO and the RTR to evaluate 2:00 PM – 3:30 PM the efficacy, utilization, and benefits of the IDEO and RTR. This

SUND workshop will help the audience understand the biomechanics behind the IDEO, physiology behind the RTR, the effective ways N ew Horizon Workshop: ORS/OTA - Systemic Inflammation both have been used to improve the clinical outcomes of our and Organ Dysfunction in A severely wounded service members and the future applications of Y Multiply Injured Patients both innovations. Room 113 - 114 The Return to Run Pathway - The Physiology of a Successful Organizer: Rehabilitation Program Todd McKinley, MD, Indiana University Methodist Johnny Owens, CPT, Brooke Army Medical Center Multiply injured patients sustaining major orthopaedic injuries The Clinical Effects of Return to Run Pathway and IDEO are at risk to develop sustained high magnitude inflammation on Patient Outcomes and organ dysfunction. Evidence continues to accumulate Daniel J. Skinner, MD, United States Army demonstrating that endogenous inflammation secondary to The Biomechanics of the IDEO: How Does it Work? tissue damage and ischemia plays a central pathoetiologic role Jason M. Wilken, PhD, United States Army in propagating inflammation leading to organ dysfunction. This workshop will highlight scientific progress in understanding the mechanisms causing systemic inflammation and to discuss the clinical significance of basic scientific progress. Systemic Inflammation and Organ Dysfunction: Clinical Manifestations in Multiple Injured Patients Sustaining Major Fractures H. Christopher Pape, MD, University of Aachen Molecular Mechanisms of Systemic Inflammation in Multiply Injured Patients Timothy R. Billiar, MD, University of Pittsburgh Medical Center Therapeutic Interventions: Pre-Clinical Models to Treat Systemic Inflammation and Damaged Associated Molecular Patterns Todd McKinley, MD, Indiana University Methodist

30 ORS GRANTS T he ORS would like to congratulate all Grant Recipients!

ORS Collaborative Exchange Grant ORS/RJOS Young Female Investigator Travel Grant The ORS Collaborative Exchange Grants foster orthopaedic research The ORS/RJOS Young Female Investigator Travel Grant promotes by supporting interaction between research institutions. This grant, and supports young female investigators in the field of orthopaedic of up to $7,500, provides investigators at any stage of their career an research. This $1,000 grant represents the synergy of female opportunity to visit a research lab for the purpose of collaboration leadership in the act of inspiring the younger generation of women and knowledge exchange. in the field. The RJOS and WLF/ORS will present one travel award to 2015 Recipients: a young female trainee whose abstract is accepted to an ORS annual Meeting. Dominik R. Haudenschild, PhD 2015 Recipient: Chantal M. de Bakker

Virginia Ferguson, PhD

FOR MORE INFORMATION ON ORS GRANTS, ELIGIBILITY Y AND DEADLINES, PLEASE VISIT A http://www.ors.org/early-careernew-investigators-awards/ SUND

31 SUND AY | PROGRAM DETAILS Sunday, March 29, 2015

I mproving the Translational Success of Cell-Based Therapies Room 118 - 120 PAPER PRESENTATIONS Organizers: 3:45 PM – 4:45 PM Jennifer J. Bara, PhD, AO Research Institute See page 34 Marietta Herrmann, PhD, AO Research Institute Geoff Richards, PhD, AO Research Institute This workshop, will address the clinical, scientific, and industrial requirements for the successful translation of cell-based therapies into both the clinic and market with an emphasis on educating investigators new to the translational process. By identifying current POSTER RECEPTION I challenges and ascertaining the perceptions and needs of future 4:45 PM – 6:00 PM investigators, we will make suggestions and encourage workshop participants to put forward innovative ideas on how to improve our Marquee Ballroom rates of translational success in the future. Clinical Considerations for Translational Success Poster Session I presenters should be available at their Theodore Miclau, MD, University of California, San Francisco posters during this reception to answer questions. Scientific Considerations for Translational Success Christopher H. Evans, PhD, Mayo Clinic Poster Session I removal is 6:00 PM – 6:30 PM Industrial Considerations for Translational Success

SUND Anthony Ratcliffe, PhD, Synthasome, Inc.

A PROFESSIONAL ADVANCEMENT SESSION ORS AWARDS GALA Y Finding a Partner in Research 7:00 PM – 10:00 PM 2:00 PM - 3:30 PM Vista Ballroom Room 121 - 122 Organizer: The ORS Corporate Affairs Committee Join us for an elegant evening honoring these Moderators: Jeremy Rawlinson, PhD outstanding leaders in the Orthopaedic Research Michael Ominsky, PhD Community: The recipients of the William Harris Award, Collaboration is one hallmark of good research and research is Marshall Urist Award, Alfred Shands Award, Kappa Delta strengthened when it is collaborative. Most challenging research Research Awards, OREF Clinical Research Award, CORR® problems are multi-disciplinary and multi-factorial. This requires researchers to reach outside their core expertise to make common ORS Richard A. Brand Award for Outstanding Research connections. Why is it important to collaborate? What are the ORS/OREF Distinguished Investigator Award, ORS best ways to find a partner in research? These and other questions Women’s Leadership Award, the ORS New Investigator will be considered in this workshop. Participants will learn about modern tools that assist in the collaborative process, understand Recognition Awards (NIRA), the ORS Outstanding the impact of collaboration on advancing science and obtaining Achievement in Mentoring Award and the ORS Video grant funding, and compare collaborative approaches from both Outreach Competition Awards. academic and industrial perspectives. Importance of Collaboration in Academia New this year, The ORS New Initiatives Committee Jeff Lotz, PhD,U CSF, CA will be holding a Silent Auction during the Gala to The ORS and its Role in Encouraging Collaboration benefit orthopaedic research and the ORS/OREF Grants Tammy L. Haut Donahue, PhD, Colorado State University Campaign. Collaboration Between Industry and Academia: Guidelines for a Successful Relationship Pre-registration required Dick Tarr, MS, Kannapolis, NC $115 ORS Members/$125 Non-Members/ $1,000 for a table of 10

32 Congratulations to all of the 2015 Award Recipients

2015 Kappa 2015 CORR® ORS/OREF Delta Young ORS Richard Distinguished Investigator A. Brand Award Investigator Award for Outstanding Award Robert L. Mauck, PhD, Orthopaedic Adele Boskey, PhD, University of Research Hospital for Special Pennsylvania Edward M. Surgery Co-Authors: Dawn Schwarz, PhD, M. Elliott, PhD and Jason A. Burdick, University of Rochester ORS William H. PhD Engineering Dense Connective A Multiplex Assay of Host Immunity Tissues: Mechanical, Material, and against S. aureus for Osteomyelitis Harris, MD Award Mechanobiologic Considerations Patients Marco Caicedo, PhD, 2015 Kappa Orthopedic Analysis, W omen’s LLC Delta Ann Doner Leadership Vaughan Award Forum Award Steven A. Olson, MD, Marjolein van der Duke University Meulen, PhD, Co-Authors: Farshid Cornell University Guilak, PhD, Virginia ORS Marshall R. Urist, MD Award Kraus, MD, PhD,

Mauro Alini, PhD, Y Bridgette Furman, BS, and Janet AO Research Institute A Huebner, MS Alfred R. Shands, Davos Early Inhibition of Proinflammatory Jr., MD Award Cytokines Prevents Post-Traumatic SUND Arthritis: Insights from the Natural Linda Sandell, PhD, History of Arthritis Developing after Washington University Intra-Articular Fracture in St. Louis 2015 Kappa ORS Outstanding Delta Elizabeth Achievement in Winston Lanier Mentoring Award Dawn Elliott, PhD, Award 2015 Video University of Delaware William D. Bugbee, MD, Outreach Scripps Clinic Competition Co-Authors: Andrea L. Pallante-Kichura, PhD, First Place Simon Görtz, MD, Robert Sah, MD, ScD, and Emily Hargrave- David Amiel, PhD Thomas ORS Outstanding Osteochondral Allograft Transplantation The Rhythm Achievement in in Cartilage Repair: Graft Storage of the Joints Mentoring Award Paradigm, Translational Models, and Steven A. Goldstein, PhD, 2015 Video Clinical Applications University of Michigan Outreach 2015 OREF Competition Clinical Research Second Place Award Nico Verdonschot, PhD Stuart L. Weinstein, MD, TLEMsafe Patient- AAOS Women’s University of Iowa SpecificS urgical Co-Author: Lori A. Navigation Health Issues Dolan, PhD Advisory Board The Evidence Base Award for the Prognosis and Treatment of Douglas J. Adams, PhD, Adolescent Idiopathic Scoliosis University of Connecticut Health

33 SUND AY | SESSIONS 8:00AM–9:00AM Sunday, March 29, 2015

Time Session 11 Session 12 spotlight Session 13 spotlight SESSION 14 Session 15 Biomaterials for Bone Knee Mechanics Bone Necrosis Pain Pathways Tendon/Ligament Cell Repair & Therapies in Biology Experimental OA

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Joel Boerckel, PhD and Sally Arno, PhD and Lee E. Rubin, MD and C. Wayne McIlwrath, DVM, Hani A. Awad, PhD and Nelly Fergal J. O’Brien, PhD Helen E. Kambic, PhD Claudia Loebel, MD PhD and Kyle D. Allen, PhD Andarawis-Puri, PhD

8:00 AM Paper No. 0065 Paper No. 0071 Paper No. 0077 Spotlight Speaker Paper No. 0083 Response to Laser Sintered 3D Trochlea Morphology Is Factors In The Necrotic Bone Anne-Marie Malfait, MD, PhD Disruption of TGFβ Signaling in the Porous Trabecular Titanium Correlated With With Proximal Mediate Uncoupled Bone Scx Cell-lineage Leads to Tenocyte Constructs Occurs in a Cell Femur Geometry. Remodeling By Increasing Dedifferentiation and Tendon Maturation Dependent Manner Tim A.E.J. Boymans, Samantha J. Migration And Differentiation Degeneration Alice Cheng, Aiza Humayun, Barbara D. Wright, Bernd Grimm, Anthony W. Of Osteoclast Precursors And Guak-Kim Tan, Anna G Stabio, Brian A Boyan, Zvi Schwartz Miles, Oliver Kessler Decreasing The Expression Of Pryce, Doug R Keene, Ronen Schweitzer Osteogenic Coupling Factors From Osteoclasts Following Ischemic Osteonecrosis Of The Femoral Head Naga Suresh Adapala, Ryosuke Yamaguchi, Simone Arvisais-Anhalt, Olumide Aruwajoye, Matthew Phipps, Harry Kim

8:10 AM Paper No. 0066 Paper No. 0072 Paper No. 0078 Paper No. 0084 Novel In-Situ Setting Bioglass based Repetitive Stress Cycle Numbers Genome Wide Association Study Of Adult Mesenchymal Stem Calcium Phosphate Bone Cements. Greater Than Physiologic Osteonecrosis Of Femoral Head In Pain Pathways in Experimental Cells Mimic Embryonic Tendon Melanie J Coathup, Niall Kent, Robert Decrease Tibial Metaphyseal The Korean Progenitor Cell Responses to Hill, Roberta De Godoy, Wen-Yu Quak, Bone Volume and Density In Seung-Hoon Baek, Tae-Ho Kim, Jun Tendon Development Factors Lyris Onwordi, Gordon W Blunn Growing Knees Young Kim, Shin-Yoon Kim Jeffrey P Brown, Thomas V Galassi, Austin V. Stone, David L Glos, Aron Catherine K Kuo

SUND Bercz, Kevin Little, Donita I Bylski- Austrow, Eric J. Wall

8:20 AM Paper No. 0067 Paper No. 0073 Paper No. 0079 Paper No. 0085

A The effect of local delivery of Iron Novel In Vivo Micro-Computed A Combined Treatment of Sox9-lineage Cells Are Activated

Y Chelators on Bone Regeneration Tomography Metrics of Joint Gene-Modified StemC ells and And Recruited During Neonatal and Osteoclast Mediated Bioceramic Incongruity Predict Arthritis in a Oxygenated Scaffolds for Scaphoid Tendon Healing Bone Graft Resorption. Knee Fracture Model Nonunion with Avascular Necrosis Kristen Howell, Ronen Schweitzer, Alice Justin Drager, Zeeshan Sheikh, Yu Ling Tyler J Vovos, Bridgette D Furman, Wafa Tawackoli, Doron Cohn Yakubovich, H Huang Zhang, Abhishek Kumar, Edward Harvey, Kelly A Kimmerling, Gangadhar David Kulber, Dan Gazit, Zulma Gazit Jake Barralet Utturkar, Louis E DeFrate, Farshid Guilak, Steven A Olson

8:30 AM Paper No. 0068 Paper No. 0074 Spotlight Speaker Paper No. 0080 Paper No. 0086 Extrusion-based Three-dimensional Gait Comparison of Bicruciate Edward J. Harvey, MD, FRCSC A Novel, Locally Delivered TrkA The Cellular and Matrix Dynamics Printing Of Porous Bone Retaining and Cruciate Inhibitor for the Treatment of Joint of Enthesis Growth Extracellular Matrix Scaffolds Sacrificing Knee Arthroplasties Pain: Efficacy in Preclinical Models Nathaniel A Dyment, Andrew P Ben P Hung, Joshua P Temple, Vincent Using Machine Learning of Arthritis Breidenbach, Andrea G Schwartz, Ryan Beachley, Jennifer H Elisseeff, Warren Gareth G Jones, Margarita Kotti, Carl R Flannery, Nance Moran, Dominick P Russell, Lindsey Aschbacher-Smith, L Grayson Ruaraidh Collins, Justin Cobb Blasioli, Kerry Donahue, John Kane, Han Liu, Yusuke Hagiwara, Rulang Tatiana Gladysheva, Rafif Dagher, Rick Jiang, Stavros Thomopoulos, David L Fang, Anna Vardanyan, Dinesh Bangari, Butler, David W Rowe Chris Ho, Andre Bourque, Michael Santos, Michael Philbrook, Gloria L Matthews

8:40 AM Paper No. 0069 Paper No. 0075 Paper No. 0081 Paper No. 0087 Accelerated Neutral Atom Beam Joint Residual Laxity Intra-Articular Depot Delivery of Identification of Tendon as an Processing Improves PEEK In Vivo and Increased Cartilage Curcumin Attenuates Pain and Insulin Target Tissue: Impaired Osseointegration Contact Deformation in ACL Dysfunction in a Rat Model of Flexor Tendon Gliding and Joseph Khoury, Cathy Tkaczyk, Art Reconstructed Knees Osteoarthritis Attenuated Insulin Receptor Kurz, James Bachand, Richard Svrluga, Ali Hosseini, Guoan Li Avascular Necrosis : Not Just Bone Richard D Bell, Robby D Bowles, Timothy Signaling in a Murine Model of Michel Assad Death Anymore K Mwangi, Lori A Setton, Samuel B Type II Diabetes Mellitus Adams Fatima Bawany, Michael Geary, Caitlin Orner, Michael J Zuscik, Robert A Mooney, Alayna E Loiselle

8:50 AM Paper No. 0070 Paper No. 0076 Paper No. 0082 Paper No. 0088 Local Delivery Of Mutant Mcp-1 Walking Decreases T1rho Absence of CC - Chemokine microRNA and Associated Tissue Protein Reduced Osteolysis Induced Relaxation Times in the Articular Receptor 7 (CCR7) is Linked Remodeling Genes in Rotator Cuff By Wear Particles Orthopaedic Cartilage of the Knee to Reduced Structural and Repair - A Rat Model Implant Wear Particles In Vivo Lindsey C. Michel, Charles E Spritzer, Functional Manifestations of Knee Erik Contreras, Fuxin Wei, Michael Xinyi Jiang, Taishi Sato, Michael Keeney, Gangadhar M. Utturkar, Sophia Y Osteoarthritis in a Murine Model Khazzam, Christopher Chen Zhenyu Yao, Kensuke Egashira, Stuart Kim, Claude T. Moorman, William E. Carla R Scanzello, Justin Gan, Vu T. Goodman, Fan Yang Garrett, Louis E DeFrate Nguyen, Charles A Bush-Joseph, Nikhil N Verma, Susanna G Chubinskaya, Anne-Marie Malfait, George R Dodge

34 SUND AY | SESSIONS 9:15AM–10:15AM Sunday, March 29, 2015

Time Session 16 Osteoblasts/ Session 17 spotlight SESSION 18 spotlight SESSION 19 Session 20 Progenitor Cells Total Hip Replacement Imaging and Bone Knee OA Repair Tendon/Ligament Repair Metal Wear Reactions Healing & Tissue Engineering

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Jinxi Wang, MD, PhD and Michael M. Morlock, PhD, Jeffry S. Nyman, PhD and Louis E. DeFrate, PhD and Stavros Thomopoulos, PhD Nicola Partridge, PhD Claire Brockett, PhD Simon Tang, PhD Bingyun Li, PhD and Chunfeng Zhao, MD

9:15 AM Paper No. 0089 Paper No. 0095 Spotlight Speaker Paper No. 0104 Paper No. 0107 Mechanical Loading Attenuates One Third of 395 Failed MOM-THR Elise F. Morgan, PhD Within Subject Changes To Tibial Surface Modification with Radiation-Induced Bone Loss in Hips have Severely Corroded Taper Articular Cartilage Thickness 4-5 Chemically Modified Synovial Fluid Bone Marrow Transplanted Mice Junctions: An Elevated Blood Co/Cr Years Post Acl-injury for Flexor Tendon Reconstruction in Peter M Govey, Henry J Donahue Ratio is a Biomarker for this Erin C Argentieri, Daniel R. Sturnick, a Canine Model In Vivo Harry Hothi, Reshid Berber, Robert Mack Gardner-Morse, Mike DeSarno, Xiaoxi Ji, Ramona L Reisdorf, Andrew Whittaker, Kevin Ilo, Jay Meswania, Timothy W. Touville, Michael P Wright, R Thoreson, Steven L Moran, Gregory Gordon Blunn, John Skinner, Alister James R. Slauterbeck, Robert J. D Jay, Kai-Nan An, Peter C Amadio, Hart Johnson, Bruce D. Beynnon Chunfeng Zhao

9:25 AM Paper No. 0090 Paper No. 0096 Paper No. 0105 Paper No. 0108 Oxygen Tension Regulates What is the Prevalence of Whole Blood Stimulates ACL Harnessing Endogenous Stem/ Human Mesenchymal Stem Cell “Asymptomatic Pseudotumours” Image Assessments of the Repair in Pigs as Effectively as Progenitor Cells For Tendon (hmsc) Paracrine Functions in THA Patients with Corrosion of Biomechanics and Biology of Bone Mesenchymal Stem Cells Regeneration Joseph Paquet, Mickael Deschepper, Dual Taper Modular Femoral Stem? Healing Benedikt L Proffen, Patrick Vavken, Chang H Lee, Kristy Kao, Yena Jun, David Adrien Moya, Delphine Logeart- Young-Min Kwon, Tsung-Yuan Tsai, Braden C Fleming, Carla M Haslauer, Joo, Jeremy Mao Avramoglou, catherine Boisson- William Leone, Guoan Li, Andrew A Chad Harris, Jason T Machan, Martha Vidal, Herve Petite Freiberg, Harry E Rubash M Murray

9:35 AM Paper No. 0091 Paper No. 0097 Paper No. 0106 Paper No. 0109 Y A Early Identification and The Immune Response in Patients ACL Degeneration As An Early Enhancement of Achilles Tendon Characterization of Colony with Adverse Reactions to Metal Marker Of Future Osteoarthritic Repair Viscoelasticity with Blockade Founding Connective Tissue Debris Changes In The Knee of Matrix Metalloproteinase Progenitors

Masahiro Hasegawa, Shinichi Miyazaki, Eric Duerr, Ata A Rahnemai-azar, Freddie Jolanta Norelli, John Schwartz, Mark SUND Edward Kwee, Kimerly Powell, Takahiro Iino, Noriki Miyamoto, Hiroki H. Fu, James J Irrgang Drakos, Nadine Chahine, Daniel Grande George Muschler Wakabayashi, Akihiro Sudo

9:45 AM Paper No. 0092 Paper No. 0098 Paper No. 0101 Spotlight Speaker Paper No. 0110 Activating Canonical Wnt/β- Damage-associated Molecular Modification OfE n Bloc Staining And Ichiro Sekiya, MD, PhD Alteration In Neuronal Signaling catenin Pathway Enhances Patterns (damps) Of Toll-like Clearing Techniques For Improved During Diabetic Tendon Repair: A DNA Repair and Promotes Receptors In Aseptic Loosened 3D Imaging Of Musculoskeletal Cell Study In Rat Cell Survival in Osteoblasts: a Total Hip Arthroplasty Properties In Situ Paul W Ackermann, Aisha Ahmed, Jian Novel Anabolic Treatment for Yasunobu Tamaki, Yuya Takakubo, Ian Berke, Melanie Smith, Christopher Li, Mahmood Ahmed, Claes-Göran Radiotherapy Associated Bone Tomoyuki Hirayama, Hiroharu Oki, Price Östensson, Carol Hewitt, Paul T Salo, Damage Yasushi Naganuma, Kan Sasaki, Stuart David A Hart Abhishek Chandra, Tiao Lin, Wei-Ju B Goodman, Yrjö T Konttinen, Michiaki Tseng, Ji Zhu, Keith Cengel, Bing Xia, Takagi X. Sherry Liu, Ling Qin

9:55 AM Paper No. 0093 Paper No. 0099 Paper No. 0102 Paper No. 0111 The Role of Transduced Bone Females with Painful TJAs Exhibit Multi-modal Imaging For Structure- The Effect of Sex on the Marrow Cells Over-Expressing a Higher Incidence and Severity of Function Characterization Of Biomechanical Outcomes of BMP-2 in Healing Critical Sized Hypersensitivity to Implant Metals Periosteum’s Smart Properties Bio-enhanced Anterior Cruciate Defects in a Mouse Femur Compared to Males: Implications Renee Whan, Joanna L. Ng, Ulf Knothe, Ligament Repair: A Large Animal Michael J Pensak, Seung-Hyun Hong, for Sex Differences in Risk of Melissa Knothe Tate Synovial Mesenchymal Stem Cells Pre-clinical Study Alex G Dukas, Brian Tinsley, Hicham Implant Failure to Repair/Reverse Knee OA: From Ata M Kiapour, Braden C Fleming, Martha M Drissi, Amy Tang, Mark Cote, Marco Caicedo, Edward Solver, Latasha Bench to Clinic M Murray Osamu Sugiyama, David W Rowe, Jay Coleman, Nadim Hallab Lieberman

10:05 AM Paper No. 0094 Paper No. 0100 Paper No. 0103 Paper No. 0112 Macrophage Migration Will New Metal Heads Restore the Fatigue Failure in Cancellous Bone Elongation Of The Anteromedial Inhibitory Factor Regulates Mechanical Integrity of Corroded is Primarily Due to Propagation of And Posterolateral Bundles Of The Senescence of Human Trunnions at Revision THR? Microdamage from Pre-existing Acl During Hyper-extension Of The Mesenchymal Stem Cells under Philip C Noble, Aditya Derasari, Microdamage Sites Knee: Implication To Double-bundle Hypoxia Jonathan E Gold, Jerry Alexander, Ashley M Torres, Jonathan B. Matheny, Acl Reconstruction SunMi Palumbo, Tsung-Lin Tsai, Sangwoo Kim, Stephen Incavo Marysol Luna, Clare M Rimnac, Yong Feng, Tsung-Yuan Tsai, Jing-Sheng Wan-Ju Li Christopher J Hernandez Li, Xudong Liu, Hai Hu, Changqing Zhang, Guoan Li

35 SUND AY | SESSIONS 3:45PM–4:45PM Sunday, March 29, 2015

Time Session 21 Session 22 SPOTLIGHT Session 23 Session 24 Diagnostic Imaging: Total Hip & Knee PTOA: Studies in Preclinical Spine Therapeutics From Spine to Cartilage Replacement: Clinical Models Perspectives and Biomechanic

Room # 111-112 Room # 113-114 Room # 118-120 Room # 121-122

Moderators Simo Saarakkala, PhD and Melissa L. J. Mark Wilkinson, PhD (FRCS) and Christopher B. Little, DVM and Koichi Masuda, MD and Nadeen O. Knothe Tate, PhD Mario Lamontagne, PhD Dominik R. Haudenschild, PhD Chahine, PhD

3:45 PM Paper No. 0113 Paper No. 0119 Spotlight Speaker Paper No. 0128 qMRI T2 Texture Change To Articular Cartilage Total Joint Arthroplasty in Smokers: Donald D. Anderson, PhD Anti-InflammatoryE ffect of Hepatocyte In Humans Over 6 Months Predicts Change To Should We Wait for Patients to Quit Before Growth Factor in Acute Phase of Spinal Knee Health And Cartilage Thickness Over 2 Operating? Cord Injury Years Following ACL Injury And Reconstruction Andrew James Pugely, Christopher Martin, Yubo Kentaro Yamane, Yohei Kagawa, Kensuke Ashley A Williams, Carl S Winalski, Constance R Chu Gao, Melissa Willenborg, Kyle Duchman, John Shinohara, Noriyuki Watanabe, Aki Yoshida, Callaghan Akihiro Matsukawa, Toshifumi Ozaki

3:55 PM Paper No. 0114 Paper No. 0120 Paper No. 0129 Changes in Tibiofemoral Gait Kinematics Clinically Anchored Benchmarks for Gait Low-energy Extracorporeal Shock Wave Are Associated with Regional Cartilage Improvement after Total Hip Arthroplasty Therapy Promotes VEGF Expression and Morphological Changes Kharma C Foucher Angiogenesis and Improve Locomotor and Eric Thorhauer, Kimberly Sass, Andrew Sensory Functions after spinal cord injury Sivaprakasam, James J Irrgang, Freddie H. Fu, Scott Kenichiro Yahata, Hiroshi Ozawa, Haruo Kanno, Tashman Seiji Yamaya, Satoshi Tateda, Kenta Ito, Hiroaki Shimokawa, Eiji Itoi

4:05 PM Paper No. 0115 Paper No. 0121 Progress Toward Better Understanding, Paper No. 0130 The Relationship Between Cartilage And Modern Implants Facilitate Enhanced Predicting, and Preventing Post-Traumatic Annulus Fibrosus Cells And Il-1beta OA

SUND Subchondral Bone And Their Effect On Patient Outcomes: Results of A Prospective Independently Regulate 3d Axonal The Mechanical Properties Of Human Double-Blind Randomised Controlled Trial Outgrowth From The Cultured Dorsal Root Metacarpophalangeal Joint Cartilage David F Hamilton, Hamish Simpson, Colin R Ganglions (DRG) Daniel Ellis, Ben Lakin, Joshua Shelofsky, Mark Howie, Richard Burnett, James T Patton, Matthew Hyunchul Kim, Sameer B. Shah, Adam H Hsieh Grinstaff, Brian Snyder Moran, Paul Gaston A Y

4:15 PM Paper No. 0116 Paper No. 0122 Paper No. 0125 Paper No. 0131 Digital Tomosynthesis and High Resolution Ti-33.6Nb-4Sn Alloy Femoral Stem With Nanomechanical Symptoms in Cartilage Changes In Synaptic Transmission Of Computed Tomography as Clinical Tools Gradation of Young’s Modulus Reduces Precede Histological Osteoarthritis Signs Substantia Gelatinosa Neurons In A Rat for Vertebral Endplate Topography Stress Shielding After Total Hip Arthroplasty: after the Destabilization of Medial Meniscus Model Of Lumbar Radicular Pain Measurements: Comparison with A Biomechanical Study in Mice Yoshinori Terashima, Tsuyoshi Miyakawa, Tsuneo Microcomputed Tomography Go Yamako, Etsuo Chosa, Koji Totoribe, Shuji Basak Doyran, Wei Tong, Qing Li, Haoruo Jia, Takebayashi, Izaya Ogon, Toshihiko Yamashita Daniel Oravec, Abrar Quazi, Angela Xiao, Ellen Yang, Hanada, Norikazu Yamada, Eiji Itoi Xianrong Zhang, Motomi Enomoto-Iwamoto, Ling Michael J Flynn, Yener N Yeni Qin, Lin Han

4:25 PM Paper No. 0117 Paper No. 0123 Paper No. 0126 Paper No. 0132 High Field MRI Studies Demonstrate Biomechanical Optimization of the Angle Cartilage-specific Elf3 Knockout Mice are Effects of Single Local Injection of Local Differences in Vascular Architecture in and Position for Surgical Implantation of a Protected from Cartilage Degradation in a Anesthetic Agents on Intervertebral Disc Humans, Pigs, and Goats at a Predilection Site Straight Short Stem Hip Implant Surgically-induced Osteoarthritis Model. Degeneration: Ex Vivo and Long-Term In Vivo of Osteochondrosis Gillian E. Cook, Saeid Samiezadeh, Zachary Elisabeth Wondimu, Jun Chang, Kirsty Culley, Experimental Study Ferenc Toth, Mikko J. Nissi, Luning Wang, Jutta Morison, Mina S.R. Aziz, Habiba Bougherara, Cecilia Dragomir, Darren Plumb, Justin Quinn, Koji Iwasaki, Hideki Sudo, Katsuhisa Yamada, M Ellermann, Kevin Shea, John Polousky, Cathy Radovan Zdero, Emil H. Schemitsch Mary B Goldring, Miguel Otero Takashi Ohnishi, Takeru Tsujimoto, Norimasa S Carlson Iwasaki

4:35 PM Paper No. 0118 Paper No. 0124 Paper No. 0127 Paper No. 0133 Neutrophil-specific, Near-infrared The Effect of Stem Length on Strain and Absence of CC - Chemokine Receptor 7 Effective Systemic Mesenchymal Stem Cell Fluorescence Imaging of Acute Intervertebral Micromotion in the Proximal Femur (CCR7) is Linked to Reduced Structural Therapy for Vertebral Compression Fractures Disc Herniation following Total Hip Arthroplasty and Functional Manifestations of Knee Dmitriy Sheyn, Wafa Tawackoli, Galina Shapiro, Li Xiao, Mengmeng Ding, Yi Zhang, Mahendra D Scott R Small, Sarah E Hensley, Paige L Cook, Osteoarthritis in a Murine Model Deuk Soo Jun, Young Doo Koh, Susan Su, Maxim Chordia, Tao Wang, Francis H Shen, Li Jin, Xudong Rebecca A Stevens, Renee D Rogge, Michael E Carla R Scanzello, Justin Gan, Vu T. Nguyen, Bez, Zachary Sharfman, Zulma Gazit, Gadi Pelled, J Li Berend Charles A Bush-Joseph, Nikhil N Verma, Susanna Hyun W Bae, Dan Gazit G Chubinskaya, Anne-Marie Malfait, George R Dodge

36 M ONDAY | meeting highlights Monday, March 30, 2015

m 6:30a -7:45am m 10:00a -11:00AM Animal Welfare in Orthopaedic Research: Focus on Refinement and Reduction Room 116 Research Interest Group (RIG): General Session: Shands Lecture, Good and Bad Animal Models Presidential Address, 1st Vice The Realities of Commercializing Room 106 - 107 Presidential Address, and ORS Orthopaedic Technologies: Business Business Meeting Strategies, Funding, Partnerships, and Room 118 - 120 Juggling Academic & Corporate Roles m 7:00a -9:45am Room 111-112

m 11:15a -12:15Pm ORS/MSTS The Osteoclast Present Your Science: Transforming and Bone Diseases Technical Talks with Melissa Marshall Room 118 - 120 Room 117 Sessions Publications Workshop: Improve Your Aging & OA Chances of Getting Published m 8:00a -9:00am Room 118-120 Room 117

Genetics: Bone Development, Professional Advancement Session: Sessions Bone Aging Rising to the Top: Leadership Success Room 111-112 in Academics Mediators of Joint Repair Room 121-122 Room 118-120 Shoulder and Elbow - Disease Process Room 113-114 Osteocytes and Mechanobiology m 3:30P -4:15Pm Room 111-112 Spine Disc Biology and Repair Room 121-122 Shoulder and Elbow Arthroplasy Awards Session: Urist Lecture, NIRA Awards, Video Outreach Competition Y

Room 113-114 Muscle/Tendon Biology and Repair A Room 116 Awards, Harris Award, WLF Award, Tendon/Ligaments-Mechanics ORS/OREF Collaborative Exchange Room 121-122 Award, Distinguished Investigator OND m 12:30P -1:30Pm Award, ORS Outstanding M Biglycan in Bone Healing Achievement in Mentoring Award Spotlight Session: Room 118 - 120 Room 116 Poster Walking Tours Marquee Ballroom m 4:15P -5:30Pm m 9:00a -5:30Pm New Investigator Networking Session: Position Yourself for a Successful Career: Setting Foundational Early Career Goals Poster Reception II (authors present) Poster and Exhibit Hall Open Room 121-122 Innovation Central/Marquee Ballroom Innovation Central/Marquee Ballroom Industry Connect Room 116 OUT m 7:30P -10:00Pm 9:15Am-9:45Am SOLD m 1:45P -3:15Pm Women’s Leadership Forum Reception Refreshment Break Vista Ballroom Innovation Central/Marquee Ballroom Workshops

ORS/POSNA Key Concepts of Musculoskeletal Infection Room 113 - 114

37 M ONDAY | PROGRAM DETAILS Monday, March 30, 2015

ANCILLARY EVENT GENERAL SESSION G ood and Bad Animal Models for Orthopaedic Research: 10:00 AM – 11:00 AM Scientific and Ethical Considerations Room 118 – 120 6:30 AM – 7:45 AM

Room 106 - 107 ORS Shands Lecture Organizer: Linda J. Sandell, PhD Stephan Zeiter, PhD, AO Research Institute Objectives: There is a scientific and ethical imperative that clinically most relevant models are used for orthopaedic research. Scientifically, the models should mimic as much as possible the (human) clinical situation. Ethically, according to the 3R principle, the number of animals used should be kept a minikum and potential pain, suffering, or distress should be minimized in all animals used in ORS Presidential Address order to enhance animal welfare. Mary B. Goldring, PhD

COMMUNICATIONS WORKSHOP P resent Your Science: Transforming Technical Talks with Melissa Marshall (Formerly The Craft of Scientific Presentations Workshop) 7:00 AM – 9:45 AM Room 117 Incoming Presidential Address Melissa Marshall, Penn State University Mathias P. G. Bostrom, MD

M This workshop has three goals: (1) to teach participants effective

OND strategies for structuring their research presentations; (2) to have participants completely rethink the design of presentation slides; and (3) to have participants analyze what would be their best A

Y delivery style. These goals are reached through lecture, discussion, analysis of filmed presentations, and exercises. In addition, workshop attendees will learn effective strategies for making an “elevator pitch” (a 1 – 2 minute summary) about their research. Video examples of effective elevator pitches will be shown and analyzed. ORS 2015 Annual Business Meeting AGENDA

Pre-registration required $20 ORS Members /$25 Non-Members Year in Review – Mary B. Goldring, PhD, ORS President ORS Priorities – Mathias Bostrom, PhD, 1st Vice President Collaborations – Farshid Guilak, PhD, 2nd Vice President PAPER PRESENTATIONS Finance Report – Gloria Matthews, PhD, Treasurer 8:00 AM – 9:00 AM ORS Newly Elected Officers, Committee Members See page 40 Welcome to New Members

BREAK PAPER PRESENTATIONS 9:15 AM – 9:45 AM 11:15 AM – 12:15 PM Innovation Central/Marquee Ballroom See page 41 Visit with exhibitors and view posters in Innovation Central. Refreshments will be served.

38 M ONDAY | PROGRAM DETAILS Monday, March 30, 2015

POSTER WALKING TOURS AGENDA 12:30 PM – 1:30 PM 12:30 – 12:35Pm Innovation Central/Marquee Ballroom Welcome & Introductions Nelly Andawaris-Puri, PhD and Devina Purmessur, PhD

Poster Walking Tours Poster Session II Tours will feature posters in the following topics: 12:35 – 12:50Pm (Authors may be present.) Grant Submissions Strategies Stavros Thomopoulos, PhD Biomaterials – Posters 1125, 1127, 1155 and 1182 Bone Biology – Posters 1402, 1419, 1440, 1452 and 1476 Bone Fracture – Poster 1506 12:50 – 1:05Pm Cartilage, Synovium Gaining National and International Reputation & Osteoarthritis – Posters 1199, 1204, 1274 and 1304 Gordana Vunjak-Novakovic, PhD Foot and Ankle – Posters 1899 and 1902 Meniscus – Posters 1321 and 1372 1:05 – 1:30Pm Spine – Posters 1578, 1593 and 1597 Q&A Trauma – Posters 1915 and 1916 Moderators: Nelly Andarawis-Puri, PhD and Devina Purmessur, PhD Tours are subject to change. Check sign-up board in Marquee Ballroom for confirmation of tours. INDUSTRY CONNECT 12:30 PM – 1:30 PM Room 116 NEW INVESTIGATOR NETWORKING SESSION Organizer: Position Yourself for a Successful Career: Setting Foundational The ORS Corporate Affairs CommitteeOUT Early Career Goals OUT The ORS Corporate Affairs Committee (CAC) believes that collaboration between industry and academic or medical research 12:30 PM -1:30 PM Y

SOLD A institutions plays a critical role in furthering research efforts Room 121-122 SOLD and accelerating innovative patient care. Industry Connect is an Organizer:

excellent opportunity for ORS attendees currently affiliated with OND The New Investigator Mentoring Committee

industry, directly through employment or indirectly through M Moderators: joint research programs, to network and discuss opportunities to Nelly Andawaris-Puri, PhD advance the development of partnerships in orthopaedic research. Devina Purmessur, PhD In addition, attendees will have the opportunity to give the As a young investigator, establishing early career goals can be CAC feedback on how the ORS can better meet their needs as challenging as you juggle setting-up your own program and industry representatives. teaching/service commitments. What types of grants you should Pre-registration required apply for as a junior PI and when you should apply are critical decisions faced in the early stages. In addition, establishing yourself for success and promotion is dependent on becoming a leading WORKSHOPS expert in your field at the national and international level. How can 1:45 PM – 3:15 PM you become recognized across the globe? How do you maximize my chances of getting a funded grant? From deciding when to submit your first grant to establishing yourself in the national and ORS/POSNA Key Concepts of Musculoskeletal Infection international arena, this networking session will provide guidance and advice based on ORS mentors own experiences and will focus Room 113-114 strategic grant submissions, maximizing your chances of getting Organizer: Jonathan G. Schoenecker, MD, funded, establishing effective collaborations and opportunities to PhD, Vanderbilt University network at home and overseas. Musculoskeletal infection is an unremitting process which, if not Pre-registration required rapidly identified and treated, results in substantial morbidity and mortality. Although the immune system has a great capacity to eradicate infection, for unknown reasons it is particularly inefficient at resolving infections of musculoskeletal tissue, especially in bone. Prior to the development of antibiotics and the capacity to perform surgical excision/drainage, the mortality rate of osteomyelitis was reported as high as 40%. Medical and surgical

39 M ONDAY | PROGRAM DETAILS Monday, March 30, 2015

advances during the 20th century dramatically improved outcomes The Realities of Commercializing Orthopaedic Technologies: of these patients. However, since infection of musculoskeletal Business Strategies, Funding, Partnerships, and Juggling tissue remains a significant global health care burden, there Academic & Corporate Roles is a continued and substantial need for development of novel Room 111-112 diagnostic, pharmaceutical, surgical, tissue regenerative and clinical practice guidelines to improve and potentially save the lives of Organizer: patients inflicted with infection of musculoskeletal tissue., In this Suzanne A. Maher, PhD, Hospital for Special Surgery ORS/POSNA forum we will discuss key advances and unanswered Despite the wealth of innovation in the orthopaedic sciences, few questions in order to continue the advancement in clinical care of technologies are translated to clinical use. This is in part caused by patients with musculoskeletal infection in the 21st century. the philosophical divide that exists between orthopedic scientists Improved Recognition and Treatment of Infection Induced and entrepreneurs, the fact that the path required to commercialize Comorbidity and Mortality technology is opaque, and that funding mechanisms are complex. Jonathan Schoenecker, MD, PhD, Vanderbilt University This workshop aims to de-myth the process of commercializing technology. Our goal is to highlight successful commercialization Identifying and Targeting Bacterial Factors strategies, common challenges in the translation of orthopaedic Lawson Copley, MD, Children’s Medical Center of Dallas science to industry, and new funding initiatives that are being Repairing the Damage Caused by Infection launched at the local and federal levels. Brian Snyder, MD, PhD, Children’s Hospital The Realities of Commercializing Orthopaedic Technologies: Imaging Musculoskeletal Infection Business Strategies, Funding, Partnerships, and Juggling Academic Scott B. Rosenfeld, MD, Texas Children’s Hospital & Corporate Roles Tom Cirrito, PhD, New York Bedside to Bench and Back: Translation and Commercialization of Novel Treatments from the Perspective of an Academic Animal Welfare in Orthopaedic Research: Medical Center Focus on Refinement and Reduction Michael J. Yaszemski, MD, PhD, Mayo Medical Center Room 116 The Role of the National Institutes of Health in Translating Research Organizers: from the Bench to the Bedside M Timothy E. Cooney, MS, UPMC Hamot Medical Center Gayle Lester, PhD, Institute of Arthritis and Musculoskeletal and Skin OND Laurie R. Goodrich, DVM, PhD, Colorado State University Diseases, National Institutes of Health It remains a foregone conclusion that animals have helped to A

Y advance knowledge in the area of medical sciences. Ethically, the welfare of research animals should form the basis for conducting in ORS/MSTS The Osteoclast and Bone Diseases vivo studies. The ‘3R’s’, Replacement, Reduction, and Refinement, constitute the principal tenets to assure conformance to this Room 118-120 ethical principal of animal welfare. This workshop will focus on, Organizers: Refinement and Reduction. Specifically, we will focus our attention Richard K. Terek, MD, FACS, Brown University on institutional compliance with PHS guidelines for the reduction Regis J. O’Keefe, MD, PhD, Washington University in of pain and distress in animals, generalized approaches to refining St. Louis animal-based protocols, and methods and unique opportunities to reduce animal use in experiments. Attendees will also be provided Osteoclast related diseases span a wide spectrum of clinical with a listing of references and resources to allow them to further problems including giant cell tumor of bone and periprosthetic their understanding of animal welfare issues and how to implement osteolysis. The mechanisms of osteoclastogenesis are not fully changes that will simultaneously benefit their animal study subjects understood, nor is the extent to which the mechanisms share and the quality of outcomes obtained from experimentation. similarities in these different scenarios. Treatment options for inhibiting osteoclast activity are only partially effective, highlighting A Look at Complying with PHS Requirements for Managing Pain and the need for a better understanding of osteoclast biology and Distress in Laboratory Animals targeted therapy. This MSTS sponsored symposium will review the Patricia Brown, DVM, NIH, Office of Laboratory Animal Welfare current understanding of osteoclastogenesis and the interaction Refinement of Induced Animal Models of giant cells and stromal cells in giant cell tumor of bone and Jeremiah Easley, DVM, Colorado State University periprosthetic osteolysis. Potential new therapeutic targets will also be highlighted. The Team Approach to Implementing the 3R’s Stephan Zeiter, DVM, PhD, DipECLAM, AO Research Institute Davos Osteoclast Biology and Clinical Challenges Wentian Yang, MD, PhD Controlled Veterinary Clinical Trials: Is There a Role for Natural Models in Proving Efficacy of Therapeutics in Orthopaedics? Osteoclast-like Cells in Giant Cell Tumor of Bone Alicia L. Bertone, DVM, PhD, Ohio State University Michelle Ghert, MD, FRCSC

40 M ONDAY | PROGRAM DETAILS Monday, March 30, 2015

Role of Osteoprogenitor Cells and Inflammatory Signaling in My American Dream: from Immigration to Leadership Perioprosthetic Osteolysis Susan Chubinskaya, PhD, Associate Provost, Academic Affairs, Francis Y. Lee, MD, PhD Rush University; The Ciba-Geigy Professor of Biochemistry with conjoint appointments at the Departments of Orthopedic Surgery & Medicine (Section of Rheumatology) Publications Workshop: Improve Your Chances of Getting Published Room 117 Organizer: ORS AWARDS SESSION Linda Sandell, PhD, Washington University in St. Louis 3:30 PM – 4:15 PM Meet with JOR® Editor-in-Chief Linda Sandell, PhD at this year’s Marshall R. Urist, MD Publications Workshop. You’ll learn how to improve the quality Award and Lecture of your journal manuscripts, what JOR® is looking for and how to Mauro Alini, PhD increase your chances of getting published. Wiley staff will also update you on maximizing visibility for your paper, navigating the ORS Women’s Leadership submission process and timeline, and taking advantage of the latest Forum Award technology. Whether you’re a new author considering submitting Marjolein vad der Meulen, PhD a paper or a seasoned journal contributor, don’t miss this unique William H. Harris, MD Award opportunity to hear directly from and interact with JOR®’s editor! Marco S. Caicedo, PhD Seating is limited

ORS/OREF Distinguished Investigator Award Adele Boskey, PhD PROFESSIONAL ADVANCEMENT SESSION ORS Outstanding Achievement in Mentoring Award Dawn M. Elliott, PhD R ising to the Top: Leadership Success in Academics Steven A.Goldstein, PhD 1:45 PM - 3:15 PM New Investigator Recognition Awards (NIRA)

Room 121-122 TBD Y A Organizer: Video Outreach Competition (VOC) ORS Women’s Leadership Forum First Place: Emily Hargrave-Thomas OND Moderator: Second Place: Nico Verdonschot, PhD M Karen B. King, PhD, University of Colorado School of Medicine Many individuals aspire to higher leadership roles within academics. The WLF Committee will engage ORS members who are in high- POSTER RECEPTION II level academics positions to discuss how to navigate academic medicine and rise to leadership in the clinical, basic science and 4:15 PM – 5:30 PM engineering arenas. The speakers will discuss how they balance Innovation Central/Marquee Ballroom academic leadership with their active research programs as well as provide practical advice for those who are interested in obtaining Poster Session II presenters should be available at their posters similar leadership roles. An open panel discussion will follow the during this reception to answer questions. presentations. Open to meeting attendees at any career stage, this session will explore the challenges and successes of academic WOMEN’S LEADERSHIP FORUM RECEPTION* leadership while illustrating the importance of career-long mentorship and sponsorship from a leadership position. 7:30 PM – 10:00 PM Making an Impact in the Dean’s Office Vista Ballroom Clare M. Rimnac, Ph.D., Associate Dean of Research, Case Western Join us in celebrating women in science! Join the members of the Reserve University (ORS Past President) Women’s Leadership Forum (WLF) at this event celebrating women Servant Leadership in science. This reception is an excellent opportunity to discuss Joshua Jacobs, MD, Chair, Department of Orthopedic Surgery, the challenges facing today’s female scientists. The 2015 Women’s Rush University; Director, Section of Biomaterials; Chair, Scientific Leadership Forum Award Winner, Marjolein C. van der Meulen, PhD, Leadership Council for the RTSC (ORS Past President, AAOS Past will be honored for her role as an outstanding mentor to fellow President) female scientists. It Takes a Village to Make a Dean Pre-registration required Barbara D. Boyan, Ph.D. Dean, School of Engineering, Virginia $60 ORS Members/$65 Non-Members Commonwealth University

41 Mon DAY | SESSIONS 8:00AM–9:00AM Monday, March 30, 2015

Time Session 25 Session 26 SPOTLIGHT Session 27 SESSION 28 Session 29 Osteocytes and Shoulder and Elbow Biglycan in Bone Healing Mediators of Joint Tendon/Ligament – Mechanobiology Arthroplasty Repair Mechanics

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Liyun Wang, PhD and Sara H. Ara Nazarian, PhD and Louis C. Gerstenfeld, PhD and Tannin Schmidt, PhD and Vincent Wang, PhD and McBride, PhD Ryan Willing, PhD Girish Pattappa, PhD Bernd Rolauffs, MD Dianne Little, PhD, DVM

8:00 AM Paper No. 0134 Paper No. 0140 Paper No. 0146 Paper No. 0149 Paper No. 0155 Tissue-level Mechanotransduction Quantitative Assesment And A Cross-Sectional Age-Wise Improved Cartilage Defect Repair Exercise Promotes Adaptation and in Cancellous Bone Submitted to Characterization Of Glenoid Assessment of Morphology and Bone Using a RHAMM-mimetic Peptide Improved Mechanical Properties in Mechanical Overload In Vivo Bone Loss For A Spectrum Formation in Perlecan-Deficient Mice Thorsten Kirsch, Natalie Danna, Bryan Fatigue Damaged Tendons Erin N Litts, Matthew G. Goff, Thu Of Disease In Glenohumeral Ashutosh Parajuli, Xiaoyu Gu, Xiaohan Beutel, Eric Strauss, Eva Turley, Cornelia Rebecca Bell, Remi Gendron, Kristen M Nguyen, Wei X Lee, Christopher J Osteoarthritis Lai, Zhishui Zheng, Catherine Kirn-Safran, Toelg, Leonard Luyt, Mary Cowman Esannason, Matthew Anderson, Hernandez Beau J Prey, Daniel J Lombardo, Liyun Wang Damien Laudier, Evan L Flatow, Nelly Vani Sabesan Andarawis-Puri

8:10 AM Paper No. 0135 Paper No. 0141 Paper No. 0147 Paper No. 0150 Paper No. 0156 3d Imaging Of Bone Adaptation In Inlay vs. Onlay: A Comparison Cross-Species Transcriptomic Analysis Oral Administration of Pirfenidone Loss of Mohawk Homeobox Gene Response To Loading of Two Glenoid Systems in Total Reveals Homologous Transcriptional Prevents Chronic Inflammation and Function Leads to Morphological Alessandra Carriero, Andre Pereira, Shoulder Arthroplasty Stages and Conserved Gene Fibrosis in a Murine Model of Post- and Biomechanical Deficiencies in Amanda Wilson, Behzad Javaheri, Sarah M Helms, Gregory P Colbath, Co-Expression Dynamics During traumatic Osteoarthritis (PTOA) the Adult Murine Patellar Tendon Andrew Pitsillides, Massimo Marenzana, Jeffrey R Gagliano, Richard J Zebrafish and Rat Bone Regeneration Deva D Chan, Jun Li, Dan N. Predescu, Andrea Lalley, Han Liu, Rulang Jiang, Sandra Shefelbine Hawkins, Luke W Pietrykowski, Ronald Y Kwon, Amarjit Virdi, D. Rick Anna H.K. Plaas Jason Shearn Breanne T Przestrzelski, John D Sumner DesJardins

8:20 AM Paper No. 0136 Paper No. 0142 Paper No. 0148 Paper No. 0151 Paper No. 0157 Targeted Disruption of BMP Bearing Surface Damage Improved Vascularisation And Repair Administration of Adipose Derived Achilles Tendons From Decorin Signaling Through Type IA Receptor Analysis of Total Shoulder Of Bone Defects By Mimicking Stem Cells Decreases Fibrosis And Biglycan Deficient Mice (BMPRIA) in Osteocyte Leads to Replacement Retrievals Across Endochondral Ossification Using Following Chronic Rotator Cuff Tear Demonstrate Inferior Mechanical Dramatic Increase in Bone Density Fixation Designs and UHMWPE Mesenchymal Stem Cells In Jonathan Gumucio, Michael Flood, And Structural Properties and Mechanical Strength Composition Combination With Collagen-based Stuart Roche, Asheesh Bedi, Christopher Predicted By An Image-based Nobuhiro Kamiya, Lin Shuxian, Matthew Louis G Malito, Farzana Ansari, Lulu Scaffolds L Mendias Empirical Damage Model Phipps, Olumide Aruwajoye, Jerry Feng, Li, Taylor Lee, Helen Park, Steve Amos Matsiko, Emmet Thompson, Daniel Joshua A Gordon, Benjamin R M Harry Kim Gunther, Tom Norris, Michael Ries, Kelly, John Gleeson, Fergal J O’Brien Freedman, Andrey Zuskov, Renato V

OND Lisa Pruitt Iozzo, David E Birk, Louis J. Soslowsky

8:30 AM Paper No. 0137 Paper No. 0143 Spotlight Speaker Paper No. 0152 Paper No. 0158

A [Ca2+]i and Actin Dynamics in Influence of Reverse Shoulder Marian F. Young, PhD Cited2 Mediates A Novel Quantitative Ultrasound Y Osteocytes in Intact Mouse Tibiae Arthroplasty Lateralization on Chondroprotective Pathway Elastography Can Quantify under Cyclic Mechanical Loading Glenohumeral Muscle Moment Involving Cross-talk Between Mechanical Tendon Healing In A Andrea E Morrell, Da Jing, Andrew D. Arms Mechanical Loading And Il-4 To Rabbit Achilles Tendon Transection Baik, X. Edward Guo Jean-David Werthel, Alexander Suppress Mmp-13 Model. Hooke, Taku Hatta, Eric Wagner, Zhiyong He, Daniel Leong, Lin Xu, John Yohei Yamamoto, Satoshi Yamaguchi, Kai-Nan An, Bassem Elhassan, John A Hardin, Robert J. Majeska, Mitchell Takahisa Sasho, Taisuke Fukawa, Sperling Schaffler, Mia Thi, Luis Cardoso, Mary B Yorikazu Akatsu, Jo Katsuragi, Jun Endo, Goldring, Neil Cobelli, Hui B Sun Hiroko Hoshi, Kazuhisa Takahashi

8:40 AM Paper No. 0138 Paper No. 0144 Paper No. 0153 Paper No. 0159 Pharmacologically Increasing An In-Vitro Study of the Intra-articular Depletion of Early Versus Standard Primary Cilia Length Enhances Effect of Reverse Shoulder Macrophages following Articular Weightbearing In Achilles Tendon Osteocyte Mechanotransduction Arthroplasty Glenosphere Size Fracture Results in Bone Ruptures: An Assessment Of Milos Spasic, Christopher Jacobs on Joint Load, Muscle Force, Resorption and Altered Synovial Tendon Length And Ankle Function and Range of Motion Small Leucine-Rich Proteoglycans: Macrophage Polarity 8 Weeks After Percutaneous Repair G. Daniel G. Langohr, Joshua Fine Tune Regulators of Skeletal Karsyn N Bailey, Bridgette D Furman, Alison N. Agres, Sebastian Manegold, William Giles, George S Athwal, Function Kelly A Kimmerling, Chia-Lung Wu, Tobias J. Gehlen, William R Taylor, James A Johnson Janet L. Huebner, Virginia B. Kraus, Adamantios Arampatzis, Georg N. Duda Farshid Guilak, Steven A Olson

8:50 AM Paper No. 0139 Paper No. 0145 Paper No. 0154 Paper No. 0160 A Specialized β3 Integrin-based Eccentric Reaming is Hybrid Nano-Matrix Enables The Biomechanical Function of Mechanotransduction on Osteocyte Biomechanically Superior Growth Plate Repair by Selectively the Anterolateral Ligament in the Processes In Situ to Posterior Augment for Promoting Chondro-Lineage Cell Setting of ACL Reconstruction Pamela Cabahug-Zuckerman, Robert Posterior Glenoid Wear Growth Evan Meeks, Ardavan Saadat, Jonathan J. Majeska, Mia M Thi, Dave C Spray, Tianyi Wang, Geoffrey Abrams, Yupeng Chen, Travis Spangler, Philip E Gold, Sabir Ismaily, Adam Brekke, Sheldon Weinbaum, Mitchell B Schaffler Anthony Behn, Emilie Cheung McClure, Scott McAllister, Hongchuan Philip C Noble, Walter Lowe Yu, Douglas Moore, Michael G Ehrlich, Qian Chen

42 Mon DAY | SESSIONS 11:15AM–12:15PM Monday, March 30, 2015

Time Session 30 Session 31 Session 32 SESSION 33 Session 34 Genetics: Bone Shoulder and Elbow - Muscle/Tendon Aging & OA Spine Disc Biology and Development, Disease Process Biology and Repair Repair Bone Aging

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Jaimo Ahn, MD, PhD and D. Samuel R. Ward, PhD and Xuhui (Phillip) Liu, MD and Amy McNulty, PhD and Qian James C. Iatridis, PhD and Rick Sumner, PhD Louis J. Soslowsky, PhD Megan Killian, PhD Chen, PhD Lisbet A. Haglund, PhD

11:15 AM Paper No. 0161 Paper No. 0167 Paper No. 0173 Paper No. 0179 Paper No. 0185 Early Onset of Bone Pathology Effect of the L-type Calcium mTOR Is Involved In The Overexpression Of Mechano- TLR4 Inhibitor Prevents Biophysical in a Murine Model of Duchenne Channel Modulators Nifedipine, Chondrogenic And Adipogenic sensitive MicroRNA-365 Promotes Changes in Nucleus Pulposus Muscular Dystrophy Verapamil and Bay K8644 on Differentiation Of Muscle-derived The Onset Of Osteoarthritis In Vivo Mechanobiology Induced by Daniel March, Clifford Voigt, Hongshuai Human Joint Capsule Cell based Stem/progenitor Cells Isolated By Up-regulating Indian Hedgehog Inflammatory Stimulation Li, Xueqin Gao, Aiping Lu, Ying Tang, Bing Collagen Gel Contraction From Zmpste-deficient Mice And Type X Collagen During Aging Timothy Jacobsen, Nadeen O. Chahine Wang, Johnny Huard Kevin A Hildebrand, Andrew R Buckley, Yohei Kawakami, Koji Takayama, Kun Yang, Yun Gao, Wentian Yang, Paul T Salo, Mei Zhang, A. Dean Befus, Makoto Kobayashi, Aiping Lu, Qian Chen David A Hart Xiaodong Mu, Jessica Tebbets, James Cummins, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu, Johnny Huard

11:25 AM Paper No. 0162 Paper No. 0168 Paper No. 0174 Paper No. 0180 Paper No. 0186 Developmental and Postnatal Correlation of Rotator Cuff Muscle Novel Transgenic Physiological Transcriptomics to Identify Brachyury Is An Essential Cartilage Remodeling and Degeneration and Tear Size with Model of Skeletal Muscle Synovial Changes Associated with Transcription Factor For Homeostasis are Mediated by Myogenic and Lipogenic Gene Contracture Disease Progression in a Cohort Maintaining Homeostasis In Synergistic Membrane-type MMP Expression in Human Biopsies Matthew C Kinney, Sudarshan of Early Osteoarthritis Patients Notochordal Cells Activity Shivam A Shah, Ioannis Kormpakis, Dayanidhi, Peter B. Dykstra, John (CHECK) Nobuyuki Fujita, Ryuichi Watanabe, Andrew Pak, Joanne Shi, Pamela G Stavros Thomopoulos, Leesa Galatz J. McCarthy, Charlotte A Peterson, Arjen B Blom, Peter L van Lent, Martijn Satoshi Suzuki, Tomohiro Hikata, Kota Robey, Kenn Holmbeck Richard L Lieber H van den Bosch, Hans Cats, Frank H van Watanabe, Ken Ishii, Takeshi Miyamoto, den Hoogen, Floris P Lafeber, Esmeralda Yoshiaki Toyama, Morio Matsumoto N Blaney Davidson, Wim B van den Berg, Peter M van der Kraan

11:35 AM Paper No. 0163 Paper No. 0169 Paper No. 0175 Paper No. 0181 Paper No. 0187 Trabeculae Bone Structure Analysis Prediction of Extensibility of the Myoblast-Seeded, Regulation Of Osteoarthritis- Mitochondrial Membrane Potential in Individuals Affected by Type Supraspinatus Musculotendinous Prevascularized Constructs associated Genes By DNA and Nuclear Changes During 1 Gaucher Disease using Micro Unit using Ultrasound Image with Augment Healing of Volumetric Hydroxymethylation Human Disc Cell Apoptosis: In Vitro Magnetic Resonance Imaging Shear Wave Elastography Muscle Loss in the Biceps Femoris Sarah E. B. Taylor, Ye Henry Li, Lakshmi and in Vivo Annulus Findings Gulshan B Sharma, Douglas D Robertson, Yoshiaki Itoigawa, John W Sperling, Mon-Tzu A Li, Laxminarayanan Dhulipala, Wing H Wong, Nidhi Bhutani Helen Elizabeth Gruber, Gretchen Jr., Minzhi Xing, Elie Harmouche, Yegor Scott Steinmann, Qingshan Chen, Hugo Krishnan, Nicholas Servies, Robert E Hoelscher, Synthia Bethea, Edward Podgorsky, Dawn A Laney, Michael J Giambini, Alexander Hooke, Shigao Guldberg, Gordon L Warren Hanley Gambello, Emily Lisi, Valynne Long, Jad Chen, Eiji Itoi, Kai-Nan An Chamieh, Michael Terk

11:45 AM Paper No. 0164 Paper No. 0170 Paper No. 0176 Paper No. 0182 Paper No. 0188 Identification of New Models for Minimally Important Differences Functional and Cellular Analysis Reduced Epidermal Growth In Vitro Growth Trajectory and In Bone Research via High-Throughput In The WORC and ASES In of Engineered Skeletal Muscle Factor Receptor (EGFR) Signaling Vivo Implantation of a Cell-Based Screening of Mice from the Patients Treated Surgically Or Units following 28 days In Vivo Enhances Cartilage Destruction in Disc-like Angle Ply Structure for Knockout Mouse Project Non-surgically For Full Thickness Keith W VanDusen, Brian C Syverud, Mouse Osteoarthritis Model Total Disc Replacement Y Douglas J Adams, Renata Rydzik, Dana Rotator Cuff Tears Jonah D Lee, Lisa M Larkin Haoruo Jia, Xianrong Zhang, Ji Zhu, John T Martin, Kensuke Ikuta, Dong A A Godfrey, Li Chen, Zhihua Wu, Caibin Joel J Gagnier, Christopher B Robbins, Frank Beier, Motomi Enomoto-Iwamoto, Hwa Kim, Christian G Pfeifer, Lachlan J Zhang, Seung-Hyun Hong, Pujan Joshi, Xi Asheesh Bedi, James Carpenter, Bruce Ling Qin Smith, Dawn M Elliott, Harvey E Smith, Jiang, Dong Guk Shin, John P Sundberg, Miller Robert L Mauck David W Rowe, Cheryl L Ackert-Bicknell TUESD

11:55 AM Paper No. 0165 Paper No. 0171 Paper No. 0177 Paper No. 0183 Paper No. 0189 A Genetic Variant in the Gamma Are The Symptoms Of Calcific Saline Injection And Needling BAPX1/NKX3.2; a Novel Tissue Engineering a Mechanically Glutamyl Carboxylase Gene Affects Tendonitis Due To Neoinnervation Improve Tendon Healing Chondrocyte Hypertrophy Robust De Novo Intervertebral Bone Quality in a Pediatric African And/or Neovascularisation? In A Collagenase-induced Molecular Switch in Osteoarthritis Disc Using Silk-Based Biomaterials, American Cohort Lisa Hackett, Neal L Millar, Patrick H Tendinopathy Model Marjolein MJ Caron, Pieter J. Emans, Adipose-derived Stem Cells and Jacqueline McKesey, Courtney Sprouse, Lam, George AC Murrell Xiangyu Gu, Richard Ma, Michael Don A.M. Surtel, Peter M van der Kraan, Physiologically Mimetic Culture Heather Gordish-Dressman, Elizabeth Schaer, Lilly Ying, Jeffrey Ngeow, Lodewijk W van Rhijn, Tim J Welting Puay Yong Neo, James CH Goh, Siew Dominic, Elizabeth Hedges, Zachary Xiang-Hua Deng, Scott Rodeo Lok Toh Kendrick, Michael Liu, Leticia Ryan, Eric Hoffman, Joseph M. Devaney, Laura L Tosi

12:05 PM Paper No. 0166 Paper No. 0172 Paper No. 0178 Paper No. 0184 Paper No. 0190 Novel Nfatc1-Cre/caALK2 Enhancer Prediction of Scapular Notching Electrospun Nanofibrous Scaffolds Galectin-1 Is A Novel Marker Stem Cells Contribution to the Mice Produce Heterotopic using 3D CT Simulation Software Enhanced with Decellularized For Cartilage Degeneration Restoration of Degenerated Ossification Localized To Joints and Video-Based Motion Analysis Extracellular Matrix to Promote In Osteoarthritis And Induces Intervertebral Discs Depends on Through Cartilage Intermediary Joel Kolmodin, Iyooh Davidson, Bong- Tissue-Specific Bioactivity for Pro-inflammatory And Catabolic their Degenerative State Shailesh Agarwal, Shawn Loder, Jae Jun, Nipun Sodhi, Naveen Subhas, Tendon and Cartilage Repair Responses In Chondrocytes In Vitro Marianna Peroglio, Stephanie Caprez, Jonathan R Peterson, Oluwatobi Eboda, Thomas E. Patteson, Zong-Ming Li, Benjamin Rothrauff, Guang Yang, Stefan Toegel, Daniela Bieder, Sabine Lorin M Benneker, Mauro Alini, Sibylle Cameron Brownley, Satoru Hayano, Joseph P Iannotti, Eric T. Ricchetti Rocky Tuan André, Hans-Joachim Gabius, Sonja M Grad Shuli Li, Kaitlyn Stettnichs, Kavitha Walzer, Idriss M Bennani-Baiti, Martin Ranganathan, David Fine, Stewart Wang, Bilban, Reinhard Windhager Steven R Buchman, Paul Cederna, Yuji Mishina, Benjamin Levi

43 TUESD AY | meeting highlights Tuesday, March 31, 2015

m 6:00a -3:30Pm m 9:45a -11:15Am Repair of Bone Fractures Spotlight Session Room 116 Poster Hall Open (no exhibits) Workshops Marquee Ballroom Chondro-Progenitors and T he Intervertebral Disc From: Chondrogenesis Development to Regeneration Room 118-120 m 8:00a -9:00Am Room 121 - 122 Tissue Engineering: Models of Bone Functional Imaging of Injury Sessions Articular Cartilage by MRI Room 121-122 Room 113 - 114 Tendon/Ligament - Collagen Structure – Function Hip Evo Devo: Adaptation of the Hip in m 2:00P -2:30Pm Spotlight Session Phylogeny and Ontogeny Room 111-112 Room 116 Posters Marquee Ballroom Bone Tissue Engineering Acute Cartilage Injury: AO Foundation Room 113-114 Collaborative Research Project Room 111 - 112 m 2:30P -3:30Pm Biomolecular Approaches to Bone Fragility Spotlight Session m 11:30a -12:30Pm Sessions Room 116 Knee - Mechanics and Modeling Cartilage Matrix Biology Poster Walking Tours Room 111-112 Spotlight Session Marquee Ballroom Room 118-120 Bone Mechanics and Finite Element Analysis Spine Mechanics m 12:45P -1:45Pm Room 113-114 Room 121-122 Knee Ligaments and Meniscus Sessions Room 116 TUESD m 9:15a -9:45Am Ankle Arthritis, Arthroplasty, and Cartilage Mechanobiology Arthrodesis Room 118-120

A Refreshment Break Room 111-112

Y Marquee Ballroom Biomaterials for Cartilage Repair Late Breaking Paper Presentations Room 121-122 Room 113-114

44 TUESD AY | PROGRAM DETAILS Tuesday, March 31, 2015

BREAK Functional Imaging of Articular Cartilage by MRI 9:15 AM – 9:45 AM Room 113-114 Marquee Ballroom Organizers: Yang Xia, PhD, Oakland University Visit with exhibitors and view posters in Innovation Central. Louis E. DeFrate, PhD, Duke University Medical Center Refreshments will be served. Magnetic resonance imaging (MRI) is one of the few imaging techniques that is highly sensitive to the molecular environment in soft tissues and is totally non-invasive. MRI of articular cartilage PAPER PRESENTATIONS in response to loading allows for functional study of cartilage. Specifically, external loading becomes an adjustable tool to force 8:00 AM – 9:00 AM the tissue to reach a new equilibrium with the environment so that See page 49 the re-distribution of the tissue’s intrinsic properties and structural adaptability can be probed in a depth-dependent manner. Clearly, healthy and diseased tissue will respond to the loading differently. This workshop aims to review the new knowledge and latest WORKSHOPS results in the area, and to discuss possible applications based on the recent studies. Three presentations are included, ranging from 9:45 AM – 11:15 AM the functional studies of cartilage-bone blocks by microscopic MRI, biomechanical measurement of knee cartilage deformation by MRI, to the in-vivo functional MRI in human subjects. T he Intervertebral Disc: From Development to Regeneration The Deformation of Cartilage by Microscopic MRI Room 121-122 Yang Xia, PhD, Oakland University Organizers: In Vivo Biomechanics of Knee Cartilage by MRI Rita Kandel, MD, Mount Sinai Hospital Louis E. DeFrate, PhD, Duke University Medical Center Makarand V. Risbud, PhD, Thomas JeffersonU niversity Towards In Vivo Weight-Bearing MRI for Knee OA The IVD is composed of three different tissues, each of different Xiaojuan Li, PhD, University of California, San Francisco origins, that merge together to form a functional tissue anchored to bone. Intervertebral disc (IVD) degeneration has a lifetime prevalence of 80% and about 1 in 50 individuals become disabled Hip Evo Devo: Adaptation of the Hip in Phylogeny by this disease resulting in annual direct and indirect costs in and Ontogeny the United States alone of over $118 billion. Until recently little Room 116 was known about the IVD but recent advances have increased our understanding of disc biology and how development can Organizer: Y

inform disc repair. This workshop will focus on the research related Sandra Shefelbine, PhD, Northeastern University A to maintaining a functional disc, specifically the advances and Understanding changes in hip morphology and what causes challenges related to understanding IVD development, regulation them is critical in evaluating etiology of hip osteoarthritis. This of disc degeneration, and biological repair or replacement of the

workshop will review current concepts of normal and abnormal TUESD degenerate disc. hip joint structure including femoroacetabular impingement Intervertebral Disc Development (FAI) and dysplasia. The topics will be discussed in the context Rosa Serra, PhD, University of Alabama at Birmingham of evolutionary changes (phylogeny) as well as changes within a person’s life time (ontogeny). Syncecan4: Regulation and Function in Intervertebral Disc Health and Disease The Role of Mechanical Loading in the Prenatal Hip Makarand V. Risbud, PhD, Thomas JeffersonU niversity Niamh C. Nowlan, PhD, Imperial College London Biological Disc Repair: The Good, Bad and the Promising The Role of Mechanical Loading in the Postnatal Hip Rita Kandel, MD, Mount Sinai Hospital Sandra Shefelbine, PhD, Northeastern University Evolutionary Changes in Hip Structure Jeremy M. DeSilva, PhD, Boston University The Role of Neuromuscular Control in Joint Forces Cara L. Lewis, PhD, Boston University

45 TUESD AY | PROGRAM DETAILS Tuesday, March 31, 2015

Acute Cartilage Injury: AO Foundation Collaborative POSTER WALKING TOURS Research Project 11:30 AM – 12:30 PM Room 111-112 Innovation Central/Marquee Ballroom Organizers: Poster Walking Tours Poster Session II Martin Stoddart, PhD, AO Research Institute Tours will feature posters in the following topics: George R. Dodge, PhD, University of Pennsylvania (Authors may be present.) The repair of acute cartilage injuries is still a significant challenge in orthopeadics. Current methods do not reproducibly result in hyaline Biomaterials – Posters 1125, 1127, 1155 and 1182 like repair tissue, and the repair is often short lived. A more active, Bone Biology – Posters 1402, 1419, 1440, 1452 and 1476 yet aging, population is increasing the frequency of injury and the Bone Fracture – Poster 1506 longer term effect of osteoarthritis is becoming more prevalent. The Cartilage, Synovium economic burden due to the ever increasing need is enormous. & Osteoarthritis – Posters 1199, 1204, 1274 and 1304 Foot and Ankle – Posters 1899 and 1902 This workshop will highlight the influence of cell, materials and Meniscus – Posters 1321 and 1372 mechanical environment in the repair of cartilage defects. In Spine – Posters 1578, 1593 and 1597 addition, strategies for screening the large number of potential Trauma – Posters 1915 and 1916 combinatorial devices will be emphasized. Interdisciplinary and international collaborations are needed to bring diverse ideas and Tours are subject to change. Check sign-up board in technologies to bear. In this workshop we will describe the outcome Marquee Ballroom for confirmation of tours. of multidisciplinary, multinational consortium with complementary expertise as a collaborative research project of the AO Foundation. Enhancing the Biology of Cartilage Regeneration Magali Cucchiarini, PhD, Saarland University Medical Center PAPER PRESENTATIONS In Vitro and In Vivo Screening of Cartilage Repair Products 12:45 PM – 1:45 PM Robert Mauck, PhD, University of Pennsylvania See page 50 Hard and Soft Materials for Articular Cartilage Repair David Elgin, PhD, AO Research Institute

PAPER PRESENTATIONS 2:30 PM – 3:30 PM See page 51 TUESD A Y

46 T uesDAY | SESSIONS 8:00AM–9:00AM Tuesday, March 31, 2015

Time SPOTLIGHT Session 35 Session 36 SPOTLIGHT Session 37 SPOTLIGHT SESSION 38 Session 39 Tendon/Ligament - Bone Tissue Biomolecular Cartilage Matrix Spine Mechanics Collagen Structure - Engineering Approaches to Biology Function Bone Fragility

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Evan L. Flatow, MD and Mathias P. G. Bostrom, MD Pamela G. Robey, PhD and Anand Agarwal, MD and Alejandro A. Espinoza Orias, Siddhesh R. Angle, PhD and Dominique P. Pioletti, Chris Arts, PhD Timothy M. Griffin, PhD PhD and Brian D. Stemper, PhD PhD

8:00 AM Spotlight Speaker Paper No. 0194 Spotlight Speaker Paper No. 0203 Paper No. 0206 David E. Birk, PhD In Vivo Re-Vascularization Deepak Vashishth, PhD Chondrocyte Expression of SIRT-1, Three-Dimensional Micro- And Osteogenesis Of Human an Enzyme Vital to Cartilage Computed Tomography Analysis Mesenchymal Stem Cells Homeostasis, is Regulated by for Spinal Instability after Lumbar Mediated By Micro-Topography Osmolarity and Glucose Levels Facetectomy in the Rat and Biochemical Cues Hannah K Heywood, David A Lee Daisuke Fukui, Koichiro Murata, Shang Song, Eun Jung Kim, Chelsea S Shintaro Shoju, Kevin Cheng, Keianne Bahney, Ralph Marcucio, Shuvo Roy Yamada, Rinoka Sato, Mitsuru Naiki, Nozomu Inoue, Koichi Masuda, Mamoru Kawakami

8:10 AM Paper No. 0195 Paper No. 0204 Paper No. 0207 Effects of Structural Polymer vs. Oxidative Stress-induced Apoptosis Repeated Nonpainful Joint Loading Non-structural Hydrogel Scaffolds And Matrix Loss Of Chondrocytes Is Can Induce Behavioral Sensitivity: on BMP-2- and Mechanical Load- Inhibited By Eicosapentaenoic Acid A Potential Mechanism of Joint- mediated Bone Regeneration Masahiko Haneda, Shinya Hayashi, Mediated Pain Regulated Assembly of the Anna McDermott, Angela Lin, Robert Biomolecular Aspects of Bone Shuhei Sakata, Takaaki Fujishiro, Ben A Bulka, Beth A Winkelstein Hierarchical Structure of Tendons E Guldberg, Joel Boerckel Quality: Strategies for Prediction Noriyuki Kanzaki, Shingo Hashimoto, and Ligaments and Prophylactic Treatment of Nobuaki Chinzei, Shinsuke Kihara, Fragility Fractures Ryosuke Kuroda, Masahiro Kurosaka

8:20 AM Paper No. 0196 Paper No. 0205 Paper No. 0208 Development of Heparin Hif-κs fine-tune Sox9-dependent SpaceflightD ecreases Bending Microparticles for Enhanced Extracellular Matrix Production in Strength and Alters Failure Mode Delivery of Bone Morphogenetic Chondrocytes in Murine Spinal Segments Protein-2 (BMP-2) Wai Kit Tam, Kenneth Cheung, Victor Britta Berg-Johansen, Ellen C Marian H Hettiaratchi, Johnna S Leung Liebenberg, Brandon R Macias, Alan R Temenoff, Robert E Guldberg, Todd Hargens, Jeffrey C Lotz C McDevitt

8:30 AM Paper No. 0191 Paper No. 0197 Paper No. 0200 Spotlight Speaker Paper No. 0209 Critical Regulatory Role for Collagen Bone Morphogenetic Protein-2 Age-related Changes in Mouse Suneel S. Apte, MD, PhD The Effect of Joint Angle V in Establishing the Unique Non-viral Gene Therapy In A New Bone at Multiple Levels of Calculation Method on Mechanical Properties of Joint Screening Model For Orthotopic Organization Intervertebral Range of Motion in Stabilizing Tendons Bone Formation In The Goat the Lower Cervical Spine

Sasidhar Uppuganti, Madeline R Y

Brianne K Connizzo, Joanna H Fried, Mei Loek Loozen, Cumhur F Oner, Wouter Girard, Siegfried G Schlunk, Alexander Yashar Assi, William Anderst A Sun, David E Birk, Louis J. Soslowsky JA Dhert, Moyo C Kruyt, Jacqueline J Makowski, Mathilde Granke, Jeffry Alblas S Nyman

8:40 AM Paper No. 0192 Paper No. 0198 Paper No. 0201 Paper No. 0210 Multiscale Analysis of Tendon SDF-1κ Enhances Low Dose BMP-2 Parathyroid Hormone Improves Adjacent Segment Range of Motion TUESD Subjected to Shear and Compression Mediated Bone Regeneration Fatigue Life But Not Whole Bone Does Not Increase 2 Years After Demonstrates Strain Attenuation, In Vivo And Tissue Mechanics Single-Level Cervical Arthrodesis Uncrimping, and Sliding Stefan Zwingenberger, Robert Julia Chen, Shefford Baker, Elizabeth Tyler West, William Anderst, Joon Lee, Fei Fang, Amrita S. Sawhney, Spencer Langanke, Corina Vater, Eik Pluhar, Adele L Boskey, Marjolein C.H. William Donaldson, James D Kang Park Lake Niederlohmann, Markus van der Meulen Sensenschmidt, Ricardo Bernhardt, Stefan Rammelt, Sven Knaack, Extracellular Matrix: Assembly, Michael Gelinsky, Klaus-Peter Proteolytic Turnover and its Günther, Stuart B Goodman, Maik Contributions to Degenerative and Stiehler InflammatoryD isorders

8:50 AM Paper No. 0192 Paper No. 0199 Paper No. 0202 Paper No. 0211 Finite Element Model Of Achilles Immunomodulation Of Tissue Mineral Density and Cortical The In Vivo Effects of Exogenous Tendon Captures Experimentally Encapsulated MSCs And Porosity Predicts Bone Toughness Crosslinking on the Mechanical Observed Cyclic Tensile Behaviour Osteogenically Differentiating and Fragility in Post Menopausal Function of Injured Rat Tail Discs Hanifeh Khayyeri, Anna Gustafsson, MSCs In Synthetic Hydrogels For Women under the Short-Term, Diurnal Ashley Heuijerjans, Marko K Matikainen, Bone Tissue Engineering Adam C Abraham, Aditya Yadavalli, Compression Loading Petro Julkunen, Pernilla Eliasson, Per Luke Amer, Mark Swartzlander, Anna Simon Tang Hsiu-Jen Lin, Leou-Chyr Lin, Weng-Pin Aspenberg, Hanna Isaksson Blakney, Themis Kyriakides, Kurt Chen, Shih-Youeng Chuang Hankenson, Stephanie Bryant

47 T uesDAY | SESSIONS 12:45PM–1:45PM Tuesday, March 31, 2015

Time Session 40 Late Breaking 41 SPOTLIGHT Session 42 SESSION 43 Session 44 Ankle Arthritis, Podium Repair of Bone Chondro-Progenitors Tissue Engineering: Arthroplasty, and Presentations Fractures and Chondrogenesis Models of Bone Injury Arthrodesis

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Sheldon Lin, MD and Jarrett D. Ronald K. June, PhD and Juan Taboas, PhD and Andreia M. Ioneseu, PhD and David A. Hoey, PhD and Cain, DPM, MSc., FACFAS Matthew J. Silva, PhD Anita Ignatius, DVM Magali Cucchiarini, PhD Michael Cross, MD

12:45 PM Paper No. 0212 Paper No. 1986 Spotlight Speaker Paper No. 0221 Paper No. 0227 Accuracy and Feasibility of Dual Deterioration of Trabecular Per Aspenberg, MD, PhD Reoxygenation Enhances TNF- Development of Pro-Resorptive Fluoroscopy to Quantify In-Vivo and Cortical Microarchitecture alpha-induced Degradation of the Therapy for the Treatment of Kinematics of the Tibiotalar and and Reduced Bone Stiffness Extracellular Matrix Produced by Heterotopic Ossification Subtalar Joints at Distal Radius and Tibia in Chondrogenic Cells Song Xue, Roberto J Fajardo, Kevin P Koren E Roach, Bibo Wang, Ashley Lynn Postmenopausal Women with Brandon D Markway, Holly Cho, Paul McHugh Kapron, Niccolo Fiorentino, Madeline Vertebral Fractures Holden, Varshini Ravi, Christopher B Singer, Charles Saltzman, Andrew Ji Wang, Emily Stein, Bin Zhou, Kyle Little, Brian Johnstone Anderson Nishiyama, Elizabeth Shane, X. Edward Guo

12:55 PM Paper No. 0213 Paper No. 1987 Paper No. 0222 Paper No. 0228 Dynamic Gait Simulation with Connexin 43 is Necessary for the NSAIDs and Healing: Different Cell Cycle Synchronization Angiogenesis Is Required for the Frontal Plane Misaligned Cadaveric Development of a Functional Effect in Different Situations During 2d Growth Enhances 3d Earliest Phases of Chondrogenesis Ankle Arthrodesis Tendon Enthesis Chondrogenesis During Ectopic Bone Formation Whitney A Wright, William R Ledoux, Eric Hua Shen, Andrea G Schwartz, Andrea R Tan, Martin Knight, J Chloe Induced by Demineralized Bone Whittaker, Calvin Hu, Dan Thuillier, Bruce Roberto Civitelli, Stavros Bulinski, Clark Hung Matrix J Sangeorzan Thomopoulos Beth Bragdon, Stephanie Lam, Sherif Aly, Elise F Morgan, Louis Gerstenfeld

1:05 PM Paper No. 0214 Paper No. 1988 Paper No. 0223 Paper No. 0229 Step-off Vs. Contact Stress Following Single Dose of Bisphosphonate Matrilin-3 Stimulates Microvascular Constructs Increase Articular Fracture Reduction: Which Preserves Long-term Gains in Chondrogenesis by Activating Early Vascularity in the Limb but Measure Is Better For Predicting Bone Mass Following Cessation Epidermal Growth Factor Signaling Impede Bone Regeneration in a PTOA? of Sclerostin Antibody in in Chondroprogenitor Cells. Composite Bone and Muscle Injury Andrew M Kern, Donald Anderson Osteogenesis Imperfecta Model Chathuraka Teekshana Jayasuriya, Model Joseph E Perosky, Bethany Meyer, Nicholas J Lemme, Zhengke Wang, Mon-Tzu A Li, Laxminarayanan Terese Jenks, David K Barton, Qian Chen Krishnan, Nick J Willett, Gordon Warren, Benjamin P Sinder, Joan C Marini, Robert E Guldberg Michelle S Caird, Kenneth M Kozloff

1:15 PM Paper No. 0215 Paper No. 1989 Paper No. 0218 Paper No. 0224 Paper No. 0230 Post-traumatic Inflammatory Tendon Mineralization Is Cells of the Innate AND Adaptive Stable And EfficientD ifferentiation Cyclooxygenase 2 Deficient Muscle Cytokine Profile in Synovial Fluid Progressive And Detrimental To Immune System jointly Influence Of Human Induced Pluripotent Derived Stem Cells Exhibit an Following Intra-Articular Ankle Tendon Biomechanical Properties the Endochondreal Ossification in Stem Cells Toward Articular Impaired Bone Regeneration Fracture Kairui Zhang, Michael W Hast, Louis Bone Regeneration Chondrocytes By Defined Growth Capacity via Cell Autonomous and Factors Non-Autonomous Mechanisms TUESD Samuel B Adams, Richard Bell, Dana L. J. Soslowsky, Motomi Enomoto- Sebastian Wendler, Claudia Schlundt, Nettles, Mark Easley, Janet Huebner, Iwamoto Alessandro Serra, Hanna Schell, Hans- Jieun Lee, Piera Smeriglio, Sarah E. B. Xueqin Gao, Arvydas Usas, Aiping Lu, Virginia B. Kraus, Steven A Olson, Lori Dieter Volk, Georg Duda, Katharina Taylor, Janice H Lai, William Maloney, Ying Tang, Johnny Huard A. Setton Schmidt-Bleek Fan Yang, Nidhi Bhutani

A 1:25 PM Paper No. 0216 Paper No. 1990 Paper No. 0219 Paper No. 0225 Paper No. 0231

Y Comparative Analysis of Fixed Exercise Protects Against TRPA1 Youthful Factors Secreted by Purinergic Signaling Regulates The Tissue Engineered Periosteum and Mobile Bearing Total Ankle Induced Joint Pain in Mice Macrophages Rejuvenate Fracture Chondrogenic Response Of MSCs To Modulates Allograft Healing Via Prostheses: Effect on Tibial Bone Erika Barboza Prado Lopes, Joanna Healing in Aged Mice Hydrostatic Pressure Elaboration Of Angiogenic Growth Strain and Tibial Component Hudson, Carlton Fernandes, Kevin Linda Vi, Gurpreet S Baht, Heather Andrew J Steward, Daniel J Kelly, Diane Factors Fixation Gaffney, Paige Parrack, Michael Whetstone, Adeline H Ng, Raymond R Wagner Michael D. Hoffman, Regine Choe, Alexandre Terrier, Maïka Guilemin, Kinter, Timothy Griffin Poon, Benjamin Alman Danielle S.W. Benoit Caroline Sieger Fernandes, Xavier Crevoisier

1:35 PM Paper No. 0217 Paper No. 1991 Paper No. 0220 Paper No. 0226 Paper No. 0232 Gait and Functional Outcomes 5 Mechanically-induced Changes Systemic Bone Loss Following Pathway Analysis to Identify Co- Autogenic Mesenchymal Stem/ years After Total Ankle Replacement In Serum Cartilage Matrix Femoral Fracture in Mice: A Culture Generated Factors Involved Stromal Cells (MSC) are Superior to Robin M Queen, Abigail L Carpenter, Biomarkers Predict Regional Mechanism for Increased Fracture in the Rejuvenation of Adult MSCs Allogeneic MSC in Regneration of Robert J Butler, Samuel B Adams Changes In Cartilage Thickness Risk for Cartilage Tissue Engineering Large Bone Defects 5 Years Later In Human Subjects Armaun J Emami, Chrisoula A Minwook Kim, Jason A Burdick, Robert Anna E Rapp, Ronny Bindl, Markus With Knee OA Toupadakis, Clare E Yellowley, David P Mauck Rojewski, Julia Kemmler, Annika Shikha Sheth, Jennifer Erhart-Hledik, Fyhrie, Blaine A Christiansen Erbacher, Hubert Schrezenmeier, Ingo Bao Do, Matthew Titchenal, Thomas P Mueller, Anita Ignatius Andriacchi, Constance R Chu

48 T uesDAY | SESSIONS 2:30PM–3:30PM Tuesday, March 31, 2015

Time Session 45 Session 46 Session 47 SESSION 48 Session 49 Knee - Mechanics & Bone Mechanics and Finite Knee Ligaments & Cartilage Biomaterials for Modeling Element Analysis Meniscus Mechanobiology Cartilage Repair

Room # 111-112 Room # 113-114 Room # 116 Room # 118-120 Room # 121-122

Moderators Aidin Masoudi, MD and Kenneth M. Kozloff, PhD and Jason Shearn, PhD and Timothy E. Hewett, PhD and Douglas J. Adams, PhD and Donald D. Anderson, PhD Mathew T. Mathew, PhD Matthew Fisher, PhD Alicia R. Jackson, PhD Ferris M. Pfeiffer, PhD

2:30 PM Paper No. 0233 Paper No. 0239 Paper No. 0245 Paper No. 0251 Paper No. 0257 Simultaneous Evaluation Of Pregnancy, Lactation, and Long-term In-vivo Evaluation Time Scales in Cartilage Impact Adhesive Barrier: Anisotropic Jump-landing Task With Three- Weaning Induce a Physiological Of A Resorbable PLLA Device For Injury and Chondrocyte Death Controlled Release for Cartilage dimensional Kinematic Analysis Redistribution of Bone Mass Regeneration Of The Anterior Lena R Bartell, Michelle L Delco, Repair by Endogenous Progenitor And Landing Error Scoring at Multiple Skeletal Sites with Cruciate Ligament Lawrence J Bonassar, Lisa A Fortier, Cell Recruitment System. Correlation Of The Minimal Impact on Bone Quality William R Walsh, Nicky Bertollo, Robert Itai Cohen Jong-Min Lee, Eun-Ah Kim, Gun-Il Im Results Obtained From The Two Chantal M de Bakker, Connie Li, Allison Arciero, Robert Stanton, Robert A Evaluation Methods. Altman, Juhanna Robberts, Wei-Ju Poggie Takatoshi Morooka, Hiroshi Tseng, X. Sherry Liu Nakayama, Kaori Kashiwa, Shunichiro Kambara, Tomoya Iseki, Takeo Nagura, Shinichi Yoshiya

2:40 PM Paper No. 0234 Paper No. 0240 Paper No. 0246 Paper No. 0252 Paper No. 0258 A Combined Experimental and Effect Of Diabetes On Bone In The Anteromedial and Posterolateral Mechanically Induced Purinergic Comparison of Cartilage Damage Computational Approach to ZDSD Rat Bundles of the Anterior Cruciate and Calcium Signaling Directs from Articulation with Peek or CoCr Subject-Specific Analysis of Jeffry S Nyman, Sasidhar Uppuganti, Ligament Exhibit Different Chromatin Condensation in Implants Human Knee Joint Laxity Mathilde Granke, Alexander Makowski, Microstructural and Material Mesenchymal Stem Cells Philip J Chuang, Carlos Aponte, Zongtao Michael D Harris, Adam J Cyr, Barbara Rowland, Paul Voziyan Properties Su-Jin Heo, Tristan Driscoll, Woojin M Zhang, Lin Song Azhar Ali, Clare K Fitzpatrick, Paul J Nathan W Skelley, Ryan M Castile, Han, Stephen D Thorpe, Dawn M Elliott, Rullkoetter, Kevin B Shelburne Timothy E York, Viktor Gruev, Robert H David A Lee, Robert L Mauck Brophy, Spencer P Lake

2:50 PM Paper No. 0235 Paper No. 0241 Paper No. 0247 Paper No. 0253 Paper No. 0259 Computational Analysis of Development of a Controlled Sex Influences the Biomechanical Dynamic Compression Results in Silk Fibroin Sponges that Cover Factors Contributing to Patellar Damaging Cyclic Loading Model of Outcomes of Anterior Cruciate Metabolomic Changes in Agarose- Articular Cartilage Defects of the Dislocation the Rabbit Ulna Ligament Reconstruction in a Pre- Encapsulated Primary Human OA Knee Enhance Cartilage Repair in a Clare K Fitzpatrick, Aruna Tumuluri, Evan G Buettmann, Matthew Silva Clinical Large Animal Model Chondrocytes Canine Model Robert Steensen, Thai Trinh, Jared Ata M Kiapour, Braden C Fleming, Donald Zignego, Jonathan Hilmer, Masahiko Saito, Arata Nakajima, Bentley, Paul J Rullkoetter Martha M Murray Ronald K June Masato Sonobe, Ryousuke Nakagawa, Shinji Taniguchi, Manabu Yamada, Naohide Tomita, Yasushi Tamada, Koichi Nakagawa

3:00 PM Paper No. 0236 Paper No. 0242 Paper No. 0248 Paper No. 0254 Paper No. 0260 Quantifying the Relationship Prediction of Vertebral Wedge The Anterolateral Ligament Carries Alterations in In Vivo Knee Biomechanical Evaluations Of between Pre-Operative Knee Strength Using Density, Load And Provides Additional Cartilage Contact After Anterior A Novel Hydroxyapatite-coated Joint Function during Gait with Morphometric and Microstructural Stability In The ACL-deficient Knee Cruciate Ligament Reconstruction PAMPS/PDMAAm Double-network Improved Joint Function Due to Properties Derived from DXA, HRCT But Carries Minimal Load When and Correlations to Clinical Hydrogel As A Potential Artificial Primary TKA. and DTS The ACL Is Intact Outcomes Cartilage Having Adhesive Ability Y A Jereme Outerleys, Cheryl Kozey, Woong Kim, Daniel Oravec, Mary Kyle Stone, Ran Thein, James Eric Thorhauer, Kimberly Sass, Andrew To The Bone Michael Dunbar, Janie Astephen Nixon, George Divine, Michael J Flynn, Boorman-Padgett, Mohammad Kia, Sivaprakasam, James J Irrgang, Freddie Susumu Wada, Nobuto Kitamura, Wilson Yener N Yeni Thomas Wickiewicz, Andrew Pearle, H. Fu, Scott Tashman Takayuki Nonoyama, Ryuji Kiyama, Carl Imhauser Shingo Semba, Jun Onodera, Yasuyuki Kawaguchi, Kotaro Higa, Takayuki Kurokawa, Jian Ping Gong, Kazunori TUESD Yasuda

3:10 PM Paper No. 0237 Paper No. 0243 Paper No. 0249 Paper No. 0255 Paper No. 0261 In Vivo Kinematics for Application of Artificial Neural Site-Specific Biomechanical Alterations in In Vivo Knee Evaluation of Porcine Collagen Customized, Individually Made Networks to Improve Predictive Properties of Human Meniscus - Cartilage Sub-Critical Impact Matrix for Cartilage Regeneration vs. Traditional TKA During a Chair Ability of Computational Joint Importance of Collagen and Fluid Inhibits Cartilage Lubrication : Comparison of Two Different Rise and Deep Knee Bend Activity Models Nonlinearities Mechanisms Membranes in Cartilage Defect Bradley A Meccia, Harold Cates, Ruchi Chande, Norma Ortiz-Robinson, Elvis K Danso, Janne T.A. Mäkelä, Edward D Bonnevie, Michelle L Delco, Model Matthew Anderle, William Hamel, Rosalyn Hobson Hargraves, Jennifer Petri Tanska, Mika E Mononen, Juuso Lisa A Fortier, Devis Galesso, Cynthia Yoorim Choi, Sung-Hwan Kim, Dong Suk Adrija Sharma, Richard D Komistek S Wayne T.J. Honkanen, Jukka S Jurvelin, Secchieri, Lawrence J Bonassar Yoon, Ji-Hoon Joo, Woo Jin Choi, Seung Juha Töyräs, Petro Julkunen, Rami K Hwan Han, Moses Lee, Jaewan Suh, Jin Korhonen Woo Lee

3:20 PM Paper No. 0238 Paper No. 0244 Paper No. 0250 Paper No. 0256 Paper No. 0262 Progression of Micro-motion, Computer-based 3d Puzzle Solving Lateral Meniscal Graft Articulation-Induced Responses of Mimicking Cartilage Tissue Zonal Micro-gaps, and Trabecular Strain For Pre-operative Planning Of Transplantation: Effect Of Superficial ZoneC hondrocytes in Organization by Engineering Shielding in Cemented Knee Articular Fracture Reductions In Fixation Method On Joint Contact Human Knee Articular Cartilage: Hydrogels with Dual Gradient of Replacements The Ankle, Knee, And Hip Mechanics During Simulated Gait Effects of Shear and Sliding Biochemical and Mechanical Cues Mark A Miller, Priyanka Srinivasan, Andrew M Kern, Donald Anderson Caroline Brial, Moira McCarthy, Tony Felix H Hsu, Alexander Y Hui, Albert C Danqing Zhu, Fan Yang Dennis Janssen, Kenneth A. Mann Chen, Hongsheng Wang, Russell F Chen, Martin K Lotz, Robert Sah Warren, Suzanne A Maher

49 POSTER SESSIONS: The ORS will have two Poster Sessions in Las Vegas. Posters are located in the Marquee Ballroom.

Poster Session 1 (PS1): Posters will be displayed on Saturday and Sunday. Poster Session 2 (PS2): Posters will be displayed on Monday and Tuesday.

Poster Presenter Hours: Authors will be available to answer questions during the following time.

Poster Session 1 Poster Session 2 Sunday, March 29 Monday, March 30 Even numbered poster presenters 4:45PM–5:25PM Even numbered poster presenters 4:15PM–4:55PM Odd numbered poster presenters 5:20PM–6:00PM Odd numbered poster presenters 4:50PM–5:30PM

Poster Categories Poster Session 1 #’s Poster Session 2 #’s American Academy of Orthopaedic Surgeons (AAOS) Best Posters AAOS1 - AAOS7 AAOS1 - AAOS7 Biomaterials - Other 263 - 319 1125 - 1186 Board of Specialty Society (BOS) Best Posters BOS1 - BOS9 BOS1 - BOS9 Bone Fracture 628 - 671 1493 - 1538 Bone/Bone Biology 537 - 627 1402 - 1492 Cancer, Tumors 1060 - 1086 1923 - 1950 Cartilage, Synovium & Osteoarthritis 320 - 452 1187 - 1320 Diagnostic Imaging 1087 - 1122 1951 - 1985 Foot and Ankle 1034 - 1043 1894 - 1905 Hand and Wrist 1022 - 1033 1880 - 1893 Hip 831 - 848 1699 - 1713 Hip and Knee Arthroplasty 849 - 980 1714 - 1840

POSTERS Infection 1044 - 1052 1906 - 1914 Knee 762 - 830 1630 - 1698 Late Breaking Poster Session 1992 - 2031 1992 - 2031 Meniscus 453 - 466 1321 - 1335 Muscle 518 - 536 1384 - 1401 New Investigator Recognition Award Finalists 25 - 64 25 - 64 Policies/Guidelines/Leadership 1123 - 1124 Not in PS2 Shoulder and Elbow 981 - 1021 1841 - 1879 Spine 672 - 761 1539 - 1629 Tendon/Ligament 467 - 517 1336 - 1383 Trauma 1053 - 1059 1915 - 1922 Women’s Health Issues Board (WHIAB) Best Poster WHIAB WHIAB

50 INTERNATIONAL COMBINED ORTHOPAEDIC BOARD OF SPECIALTY SOCIETY (BOS) RESEARCH SOCIETY (ICORS) BEST POSTERS BEST POSTERS

BOS1 American Association for Hand Surgery (AAHS) ICORS1 Chinese Orthopaedic Research Society (CORS) Does SLAC IV Exist? A Radiographic and Magnetic A novel bone targeting delivery system carrying bone- Resonance Imaging Analysis forming and anti- bone resorption phytomolecule Alexia Marie Hernandez-Soria, MD; Steve Lee, MD; Lauren icaritin for prevention of steroid-associated E. Lamont, MD; Nadja Farshad-Amacker, MD, Hollis Potter; osteonecrosis in rat model Scott W. Wolfe, MD Shi Hui Chen, Xin Luan Wang, Li Zhen Zheng, Nan Wang, Jiayong Zhang, Zhijun Yang, Ling Qin BOS2 Arthroscopy Association of North America (AANA) Repeat Meniscus Repair: What Result Can We Expect ICORS2 Chinese Orthopaedic Research Society (CORS) Paul Sousa, Benjamin Allen, Bruce Levy, Diane Dahm, TBX6 Variants: a Key Etiology for Congenital Scoliosis Michael Stuart, Aaron Krych Nan Wu, Zhihong Wu, Sen Liu, Jiaqi Liu, Zhenlei Liu, Yuzhi Zuo, Xuan Ming, Jianqiu Xiao, Xiaoli Chen, Feng Zhang and BOS3 American Orthopaedic Foot & Ankle Society (AOFAS) Guixing Qiu The Effect of a Calcaneal Osetotomy in a Novel Asymmetric Ankle Arthritis Model ICORS3 International Chinese Musculoskeletal Research Society Jack Anavian, MD; Todd A. Fellars, MD; Heather Gotha, MD; (ICMRS) Sarah Koruprolu, MS; David Paller, MS; Ryan Rich, MS; and Chondrocytes Directly Form Osteocytes in the Calcified Christopher W. DiGiovanni, MD Articular Cartilage in vivo Y. Jing, Y. Ren, J. Borrelli, Y. Xiao, Y. Liu, C. Liu, J. Feng BOS4 American Society for Surgery of the Hand (ASSH) A Comparative Study of the Effects of Muscle- ICORS4 International Chinese Musculoskeletal Research Society derived stem cell seeded Fibrin Gel and Collagen Gel (ICMRS) Interposition in an in vitro Tendon Healing Model Pregnancy, Lactation, and Weaning Induce Substantial Yasuhiro Ozasa, Anne Gingery, Chunfeng Zhao, Andrew Changes in Bone Microarchitecture and Remodeling in Thoreson, Kai-Nan An, Peter C. Amadio Rat Tibiae Chan tal de Bakker, Allison Altman, Connie Li, X. Sherry Liu BOS5 Cervical Spine Research Society (CSRS) (Basic Science Poster) ICORS5 Japanese Orthopaedic Association (JOA) Effect of rhBMP-2 on Lung Cancer Elimination of BMP7 from the developing limb Spine Metastasis in Rodents mesenchyme leads to articular cartilage degeneration Abhishek Kannan, BS, Kevin Sonn, MD, Sharath S. Bellary, and synovial inflammation with increased age MD, Chawon Yun, PhD, Sohaib Hashmi, MD, John T. Nelson, Kahaer Abula, Takeshi Muneta, Kazumasa Miyatake, Jun MD, Amruta Ashtekar, MS, Anjan Ghosh, Nicholas Shawen, Yamada, Yu Matsukura, Makiko Inoue, Ichiro Sekiya, Daniel BS, Michael S. Nickoli, MD, Jason H. Ghodasra, MD, MSCI, Graf, Aris N. Economides, Vicki Rosen, and Kunikazu Tsuji Michael Okoli, Stuart Stock, PhD, Erin L. Hsu, PhD, and Wellington K. Hsu, MD ICORS6 Japanese Orthopaedic Association (JOA) Tumor Necrosis Factor-α Modulates Wnt Signaling BOS6 Cervical Spine Research Society (CSRS) in Nucleus Pulposus Cells by Activation of (Clinical Poster)

Cyclooxygenase 2 and Prostaglandin E2 Full Body Eos Analysis Of The Maintenance Of Akihiko Hiyama, Daisuke Sakai, Joji Mochida Functional Cbva And Horizontal Gaze Among Hypo-lordotic Verses Hyper-lordotic Patients ICORS7 Korean Orthopaedic Research Society (KORS) V incent Challier, MD, Renaud Lafage, MS, Emmanuelle Activation of G protein-coupled receptor 84 with Ferrero, MD, Barthelemy Liabaud, MD, Bassel G. Diebo, capric acid inhibits RANKL-induced osteoclast MD, Shian Liu, BS, Justin S. Smith, MD, PhD, Christopher differentiation via the suppression ofNF -κB signaling P. Ames, MD, Eric O. Klineberg, MD, Peter Passias, MD, and blocks cytoskeletal organization and survival in Themistocles S. Protopsaltis, MD, Thomas J. Errico, MD, POSTERS mature osteoclasts Frank J. Schwab, MD, and Virginie C. Lafage, PhD Hyun-Ju Kim, Hye-Jin Yoon, Shin-Yoon Kim BOS7 James Robert Gladden Orthopaedic Society (JRGOS) ICORS8 Taiwan Orthopaedic Research Society (TORS) Grafting Articular Defects in the Acetabulum: The use of demineralized bone matrix for anterior Is the Medial Tibial Plateau a Suitable Donor Site cruciate ligament reconstruction: a radiographic, for Osteochondral Allografts? histologic, and immunohistochemical study in rabbits P erry S. Bradford, BA, Hugh L. Jones, BS, Jesal N. Parekh, Shan-Ling Hsu , Ching-Jen Wang PhD, Melvyn A. Harrington, MD, Philip C. Noble, PhD

ICORS9 Taiwan Orthopaedic Research Society (TORS) A facile approach toward protein-resistant biointerfaces based on photo definable poly-p-xylylene coating Chih-Hao Chang, Chiao-Tzu Su, Bing-Heng Lee, Pin-Chun Chou, Hsien-Yeh Chen 51 BOS8 Pediatric Orthopaedic Society of North America (POSNA AAO OS W MEN’S HEALTH ISSUES Angiographic Documentation of Restoration of Blood ADVISORY BOARD (WHIAB) Flow to an Ischemic Proximal Femoral Epiphyisis by ModifiedD unn Procedure for Unstable Slipped Capital BEST POSTER Femoral Epiphysis J. Benjamin Jackson, III, Steven L. Frick, Scott Broadwell, Eric Wang, Brian K. Brighton, Virginia F. Casey This poster will be presented at the podium on Monday, March 30 in Session 30: BOS9 Orthopaedic Trauma Association (OTA) Genetics: Bone Development, Bone Aging In Vivo Chemistry and Implantable Biomaterial for Targeting Therapeutics WHIAB José M. Mejía Oneto, MD, PhD; Munish C. Gupta, MD; Identification ofN ew Models for Bone Research Kent Leach, PhD; Mark A. Lee, MD; Maksim Royzen, PhD via High-Throughput Screening of Mice from the Knockout Mouse Project Douglas J Adams, Renata Rydzik, Dana A Godfrey, Li Chen, Zhihua Wu, Caibin Zhang, Seung-Hyun Hong, Pujan Joshi, Xi Jiang, Dong Guk Shin, John P Sundberg, David W Rowe, Cheryl L Ackert-Bicknell AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (AAOS) BEST POSTERS ORTHOPAEDIC RESEARCH SOCIETY BEST POSTERS AAOS1 AAOS Best Hip Poster Reliability of Modern Ceramic Femoral Heads The following posters have been chosen as the “Best” of the ORS and in over 5.7 Million Hip Implants were displayed at the American Academy of Orthopaedic Surgeons Gwo-Chin Lee, MD, Raymond H. Kim, MD (AAOS) meeting, March 25-28 at the Venetian/Sands Expo.

AAOS2 AAOS Best Knee Poster Poster No. 0963 ORS Best Hip Poster Routine Examination of Tissue from Total Knee Modularity of Metal-on-Metal Hip Implants Increases Arthroplasty is Not Cost Efficient and does Cobalt:Chromium Ratio Not Affect Patient Care Kevin Ilo, Karim Aboelmagd, Harry Hothi, Robert David Liebelt, MD, PhD, Joseph Greene, MD, Theofanis Whittaker, Asaad Asaad, Gordon Blunn, John Skinner, Zois, PA-Cm Didi Omiyi, MD, Fred D. Cushner, MD, Alister Hart Giles R. Scuderi, MD Poster No. 0867 ORS Best Knee Poster AAOS3 AAOS Best Foot & Ankle Poster Factors InfluencingTKR Joint Mechanics in the Varus Advanced Glycation End Products Inhibitor Protects Knee Against Diabetic Skeletal Muscle Atrophy Clare K Fitzpatrick, Sherrod Woods, Paul J Rullkoetter Rong-Sen Yang, MD, Shing-Hwa Liu, PhD Poster No. 1902 ORS Best Foot and Ankle Poster AAOS4 AAOS Best Hand and Wrist Poster Predicting Tibial Stress Fields Around Total Ankle An Outcome Analysis of 75 Consecutive Cases of Replacements Revision Proximal Interphalangeal Arthroplasty Matthew A Hamilton, Phong Diep, James Nunley, James Robert Van Demark, MD DeOrio, Mark Easley, Victor Valderrabano

AAOS5 AAOS Best Shoulder and Elbow Poster

POSTERS Poster No. 1117 ORS Best Hand and Wrist Poster Quantification of the Position, Orientation, and Multidimensional Ultrasound Imaging of the Wrist: Surface Area of Posterior Bone Loss in Type B2 Changes of Shape and Displacement of the Median Glenoids Nerve and Tendons in Carpal Tunnel Syndrome N ikolas Knowles, Louis Ferreira, MSc, Jay D. Keener, MD, Anika Filius, Peter C. Amadio, Marjan Scheltens, Hans George S. Athwal, MD G. Bosch, Pieter A. van Doorn, Henk J. Stam, Steven E.R. Hovius, Ruud W. Selles AAOS6 AAOS Best Spine Poster Do Upper Instrumented Vertebra Selection Poster No. 1013 ORS Best Shoulder and Elbow Poster Recommendations Predict Shoulder Imbalance? Are The Brains Of Patients With Complex Shoulder Benjamin Bjerke-Kroll, MD, Zoe B. Cheung, BS, MS, Grant Instability Wired Differently? Shifflett, MD, Sravisht Iyer, MD, Peter Derman, MD, Joseph Anthony Howard, Joanne Powell, David Hawkes, Alison Liu, MD, Matthew E. Cunningham, MD, PhD Kinghorn, Jo Gibson, Omid Alizadehkhaiyat, Graham Kemp, Simon Frostick AAOS7 AAOS Best Tumor Poster Impact of Advanced Age and Comorbidity Burden on Morbidity and Mortality after Musculoskeletal Tumor Surgery Koichi Ogura, MD, Hideo Yasunaga, MD, PhD, Yusuke Shinoda, MD, PhD, Hirotaka Kawano, MD, PhD, Sakae Tanaka, MD, PhD 52 Poster No. 0697 ORS Best Spine Poster Poster No. 0030 Progressive Pattern of Vertebral Deformity in Aptamer-Functionalized Delivery System for a Population-based Cohort Study of Vertebral Osteogenic siRNAs to Achieve Osteoblast-Specific RNA Fracture: Association with Bone Mineral Density Interference for Bone Anabolic Therapy Junichi Yamada, Koji Akeda, Norihiko Takegami, Toshihiro Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Kato, Koichiro Murata, Akinobu Nishimura, Ko Kato, Aiping Lu, Ge Zhang Akihiro Sudo Poster No. 0031 Poster No. 1060 ORS Best Tumors Poster Macrophage-associated Osteoactivin/gpnmb Mediates The Epigenetic Regulation Of SOX9 By MiR-145 Mesenchymal Stem Cell Survival, Proliferation and In Human Chondrosarcoma Migration via a CD44-dependent Mechanism Isabella Mak, Shalini Singh, Robert Turcotte, Michelle Bing Yu, Gregory Sondag, Christopher Malcuit, Min-Ho Ghert Kim, Fayez F Safadi Poster No. 0032 Therapeutic Inhibition Of Mir-214 By (asp-ser-ser)6- New Investigator Recognition liposome Encapsulating Antagomir-214 In Osteogenic Award (NIRA) Posters Cells For Promoting Bone Formation In Aged Osteoporotic Rats Baosheng Guo, Aiping Lu, Baoting Zhang, Ge Zhang

The following posters will also be presetned in the NIRA Presentations NIRA 7 - Joint Physiology & Mechanics on Saturday, March 28 from 1:15 PM - 2:15 PM Poster No. 0033 NIRA 6 - Bone Biology & Repair Orthopaedic Grade Cobalt Chromium Alloy Particle Corrosion and Biological Evaluation Poster No. 0025 Danielle de Villiers, Agata Nyga, Terry Tetley, Akramul SDF-1/CXCR4 Axis in Tie2-lineage Cells Including Hoque, Alister Hart, Julia C Shelton Endothelial Progenitor Cells Regulates Bone Fracture Healing Poster No. 0034 Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Early Phase of Wear Particle Induced Inflammation was Tomoya Kuroda, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, inhibited by NF-κB Decoy Oligodeoxynucleotide Takayuki Asahara, Masahiro Kurosaka T aishi Sato, Jukka Pajarinen, Tzu-Hua Lin, Florence Loi, Kensuke Egashira, Zhenyu Yao, Stuart B Goodman Poster No. 0026 Collagen-Based Bone Sialoprotein Implants Promote Poster No. 0035 Cranial Bone Repair by Stimulating Osteoblastic Gender Differences in Knee Laxity and Stiffness: nA In Differentiation of Dura-Derived Osteoprogenitor Cells Vitro Study of Age Matched Specimens from a Younger Paul C. Cowan, Yan Wang, Qinghua Lu, John G. Yost, Yi Population Feng, Andrew H. Miller, Jinxi Wang Daniel Boguszewski, Edward Cheung, Nirav Joshi, Keith Markolf, David McAllister Poster No. 0027 Identification of a Novel Regulatory Mechanism Poster No. 0036 underlying PTH Anabolic Action on Bone Mass and Molecular Characteristics Proving Femoroacetabular Injury Repair via Induction of Tob Required for RANKL Impingement As The Precursor To Hip Osteoarthritis Expression Nobuak i Chinzei, Shingo Hashimoto, Takaaki Fujishiro, Shuichi Moriya, Yoichi Ezura, Tadayoshi Hayata, Yayoi Izu, Shinya Hayashi, Noriyuki Kanzaki, Masahisa Hatakeyama, Kazuo Kaneko, Masaki Noda Shuhei Sakata, Shinsuke Kihara, Katsuhiko Haneda, Soshi Uchida, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 0028 Organ Culture Based Real-time Luminescence Imaging Poster No. 0037

Revealed The Circadian Clock Exists In A Fracture Sex Differences in Knee Cartilage Pressure Distribution POSTERS Healing Site Of A Mouse Femur Under Functional Loading Conditions: Implications for T atsuya Kunimoto, Hiroyoshi Fujiwara, Naoki Okubo, Yoichi Knee Osteoarthritis Risk Minami, Toshihiro Hosokawa, Ryo Oda, Toshikazu Kubo, A ta M Kiapour, Carmen E Quatman, Samuel C Wordeman, Kazuhiro Yagita Vijay K Goel, Timothy E Hewett, Constantine K Demetropoulos Poster No. 0029 MT1-MMP Mediates Plasticity and Divergence of the Poster No. 0038 Osteoblast and Adipocyte Lineages Through Cleavage Estimation Of Optimal Shoulder Orientation During of DLK1 The Acceleration Phase In Baseball Pitching From Jason A Horton, Heba Degheidy, Teresa Yang, Nozomi Minimal Shoulder Joint Load Viewpoint Sakakibara, Steven R Bauer, Pamela G Robey, Kenn H iroshi Tanaka, Toyohiko Hayashi, Hiroaki Inui, Yohei Holmbeck Takagi, Takanori Oi, Katsuya Nobuhara

53 Poster No. 0039 Poster No. 0048 Validation of MRI Quantification for Meniscus Volume The Effect of Continuous and Local IL-4 Delivery on Resection Following Partial Meniscectomy Systemic Macrophage Trafficking andP olyethylene Shiree Segev, Brian T Feeley, Sharmila Majumdar, Richard Particle Induced Bone Loss B. Souza Jukka Pajarinen, Taishi Sato, Tzu-hua Lin, Florence Loi, Ruth Zhang, Changchun Fan, Zhenyu Yao, Stuart B Goodman Poster No. 0040 Identification Of An Evolutionarily Conserved Host NIRA 9 - OA & Cartilage Response Against IsdA And IsdB As A Virulence Factor Associated With Death In Patients With Staphylococcus Poster No. 0049 aureus Musculoskeletal Infections Mechanotransduction in Articular Chondrocytes: High- Kohei Nishitani, Alexander F Rosenberg, Christopher A Strain Activates Piezo1 and Piezo2 Channels Beck, Hiromu Ito, Stephen L Kates, John L Daiss, Edward M. W. Lee, H. A. Leddy, Y. Chen, S. Lee, N. Zelenski, A. L. Schwarz McNulty, J. Coles, J. Grandl, S. Zauscher, F. Sachs, W. Liedtke, F. Guilak NIRA 8 - Cell Differentiation Fibrosis & Cancer Poster No. 0050 Poster No. 0041 Protective Mechanism Adopted by Chondrocytes Distinct Patterns Of 5hmC Acquisition Mark through Unfolding of Surface Ruffles during Chondrogenic Differentiation Mechanical Compression Sarah E. B. Taylor, Ye Henry Li, Piera Smeriglio, Madhusikta Eng Kuan Moo, Walter Herzog Rath, Wing H Wong, Nidhi Bhutani Poster No. 0051 Poster No. 0042 Feasibility and Reproducibility of a Displacement Human Mesenchymal Stem Cell and Endothelial Cell Controlled MRI-Compatible Loading Device for Interaction through Endothelin-1 Assessing Knee Articular Cartilage Deformation in Tsung-Lin Tsai, Bowen Wang, Matthew Squire, Lian-Wang Human Knees Guo, Wan-Ju Li Hongsheng Wang, Matthew F Koff, Hollis Potter, Russell Warren, Scott Rodeo, Suzanne Maher Poster No. 0043 Ex-vivo Gene Therapy-induced Cartilage Regeneration: Poster No. 0052 Comparison of Different Subpopulations of Primary Legg-Calvé-Perthes Disease Produces Chronic Hip Muscle-Derived Cells Synovitis and Elevation of Interleukin-6 in the Synovial Hongshuai Li, Aiping Lu, Ying Tang, MaCalus V Hogan, Fluid Johnny Huard Ryosuke Yamaguchi, Nobuhiro Kamiya, Naga Suresh Adapala, Elena Chen, David Neal, Hicham M Drissi, Harry Poster No. 0044 Kim Inhibitory Effect of Photodynamic Therapy with a Novel Indocyanine Green-labeled Nanoparticle and Poster No. 0053 Near-infrared Light on the Growth of Bone Metastasis Bone Marrow Stimulation Technique Augmented By of a Human Breast Cancer in vivo Ultrapurified AlginateG el Enhances Osteochondral Toshinori Tsukanishi, Masataka Sakane, Tetsuya Abe, Toru Repair In A Rabbit Osteochondral Defect Model Funayama, Shinzo Onishi, Eiichi Ozeki, Isao Hara, Masashi R ikiya Baba, Tomohiro Onodera, Daisuke Momma, Yamazaki Masatake Matsuoka, Kazutoshi Hontani, Norimasa Iwasaki

Poster No. 0045 Poster No. 0054 POSTERS RPN2 Gene Confers Osteosarcoma Lethal Phenotypes Administrations Of Tenascin-c Delay Cartilage and Determines Clinical Prognosis Degeneration In Murine Models Of Osteoarthritis T omohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Yutaka H ironori Unno, Masahiro Hasegawa, Yuriyo Matsui, Nezu, Aki Yoshida, Koji Uotani, Kazuhisa Sugiu, Toshiki Yoshiaki Suzuki, Takahiro Iino, Toshimichi Yoshida, Akihiro Omori, Takehiro Uehara, Yasuaki Yamakawa, Akira Kawai, Sudo Takahiro Ochiya, Toshifumi Ozaki Poster No. 0055 Poster No. 0046 Endogenous Stores of Latent TGF-β Serve to Maintain Oral Administration of Losartan significantly Improves the Integrity and Viability of Articular Cartilage Over Muscle Healing after Compartment Syndrome-Like Long Term Culture in Response to Physiologic and Muscle Injury Excessive Dynamic Mechanical Loading Makoto Kobayashi, Yohei Kawakami, Takanobu Otsuka, Michael B Albro, Krista M Durney, Jay J Shim, Akaljot Singh, Freddie H. Fu, Johnny Huard Gerard A Ateshian, Molly M Stevens

Poster No. 0047 Poster No. 0056 κv Integrin Depletion Inhibits Profibrotic Cell The Synovial Lymphatic System Plays a Critical Role in Activation And Skeletal Muscle Fibrosis the Pathogenesis of Osteoarthritis Iain R Murray, Zaniah Gonzalez, John Iredale, Hamish Hao Xu, Wensheng Wang, Echoe Bouta, Ronald Wood, Simpson, Bruno Peault, Neil Henderson Hengwei Zhang, Edward M. Schwarz, Micheal Zuscik, Yongjun Wang, Lianping Xing 54 NIRA 10 - Stem Cells & Tissue Repair POSTER SESSION 1 Poster No. 0057 Wnt5a Treatment Of Embryonic Stem Cell Progenitors Posters Will Be Displayed Saturday And Sunday Promotes Cartilage Repair In A Rat Chondral Defect Model PS1 Biomaterials - Other Jason D Gibson, Farhang Alaee, David N. Paglia, Ryu Yoshida, Thomas DeBerardino, Rosa Guzzo, Hicham Drissi Poster No. 0263 Mechanical And Chemical Analyses In Highly Cross- Poster No. 0058 linked Polyethylene By Raman Spectroscopy TGFβ1 Signalling in Human Mesenchymal Stem Cells is Yoshihiro Miura, Masahiro Hasegawa, Leonardo Puppulin, regulated by the Primary Cilium Akihiro Sudo, Giuseppe Pezzotti Marie-Noelle Labour, David Hoey Poster No. 0264 Poster No. 0059 Metallic Surface Modifications Reduce Immune Intervertebral Disc Regeneration Using Mesenchymal Response to Orthopedic Implants Stem/Stromal Cells Transplanted Via The End-Plate Kelly M Hotchkiss, Sharon L Hyzy, John J Ryan, Route in a Large Animal Model Zvi Schwartz, Barbara D Boyan, Rene Olivares-Navarrete Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Francesca De Strobel, Marco Bernardini, Giulia De Poster No. 0265 Benedictis, Luca Denaro, Domenico D’Avella, Rosaria Investigation Of Fretting-corrosion Behavior Of Giordano, Vincenzo Denaro Peek-metal Interfaces And Comparison With Fretting- Corrosion of Metal-metal Interfaces Poster No. 0060 Sevi Kocagoz, Eric Ouellette, Sachin A Mali, Synovial Mesenchymal Stem Cells Enhance Healing of Jeremy L Gilbert, Steven M Kurtz Meniscal Repair In The Avascular Zone of Longitudinal Tear Using A Pig Poster No. 0266 Y usuke Nakagawa, Takeshi Muneta, Shimpei Kondo, An Impact Testing Protocol for Evaluating the Masafumi Horie, Hideyuki Koga, Ichiro Sekiya Fracture Resistance of Ceramic Femoral Components for Use in TKA Poster No. 0061 M arcel E Roy, Leo A Whiteside, Kasisin Klunklin, Total Disc Replacement Using Tissue Engineered Christina M Schmidt, Paul Begeman Intervertebral Discs In An In-vivo Beagle Model Yu Moriguchi, Rodrigo Navarro, Peter Grunert, Jorge Poster No. 0267 Mojica, Katherine Hudson, Thamina Khair, Marjan Alimi, Decellularized Pericardium as a Biologic Patch for Lawrence Bonassar, Roger Hartl Annulus Fibrosus Repair Rachel McGuire, Sanjitpal Gill, Dan Simionescu, Jeremy Poster No. 0062 Mercuri The Role of Prostanoid Receptor EP4 on Adhesion Formation in Flexor Tendon Healing - Differential Poster No. 0268 Effects of Tendon-SpecificD eletion Versus Systemic Reduced Taper Fretting Corrosion Using a Zirconia- Antagonism toughened Alumina Femoral Head in a Hip Joint M ichael B Geary, Caitlin Orner, Fatima Bawany, Warren C Simulator Study Hammert, Regis J O’Keefe, Alayna E Loiselle Masayuki Kyomoto, Yuichi Shoyama, Junji Ikeda, Mikio Iwamoto Poster No. 0063 The Role of Hedgehog Signaling in Enthesis Healing Poster No. 0269 Andrea G Schwartz, Leesa M Galatz, Stavros Thomopoulos The Apatite-forming Ability of The New Ti-Nb-Sn Alloy With low Young’S Modulus Via Anodic Oxidation And Poster No. 0064 Hot Water Treatment Human, Muscle-derived Induced Pluripotent Stem H idetatsu Tanaka, Yu Mori, Atsushi Noro, Norikazu Yamada, POSTERS Cells Loaded Onto Coral Scaffolds Are Osteoinductive Shuji Hanada, Naoya Masahashi, Eiji Itoi In An Ectopic Mouse Model K arim Oudina, Joseph Paquet, Emmanuelle Massourides, Poster No. 0270 Morad Bensidhoum, Nathanael Larochette, Peter Upex, Mechanically Assisted Crevice Corrosion on CoCrMo Mickael Deschepper, Delphine Logeart, Christian Pinset, Heads after Long-term Hip Simulator Wear Testing Herve Petite Chenxi Li, Amit Parikh, Jeff Sprague, Vivek Pawar

Poster No. 0271 Metal Ion Release In Urine And Blood From Titanium Cups Cith Different Surface A lessandro Bistolfi, Andrea Cimino, davide deledda, alessandro masse, filippo castoldi, giuseppe massazza

55 PS1 Biomaterials - Cartilage Poster No. 0281 A Simulated Long-Term Degradation Study of a Novel Poster No. 0272 Artificial Medial MeniscusI mplant Functionalizing Fibrin Hydrogels with Cartilage ECM Jonathan J Elsner, Maoz Shemesh, Adaya Shefy-Peleg, Eyal Microparticles Enhances Chondrogenesis of Human Zylberberg, Eran Linder-Ganz Infrapatellar Fat Pad Stem Cells In Vitro and In Vivo Henrique V Almeida, Rajalakshmanan Eswaramoorthy, Poster No. 0282 Grainne Cunniffe, Fergal J O’Brien, Daniel J Kelly Synthetic PAMPS Gel Activates TGF-beta/BMP Signaling Pathway During The Chondrogenic Poster No. 0273 Differentiation Of ATDC5 Cells Ex Vivo Performance of an Injectable Zwitterionic Keiko Goto, Nobuto Kitamura, Taichi Kimura, Shingo Polymer Network to Supplement the Tribological Semba, Takayuki Kurokawa, Jian P Gong, Shinya Tanaka, Properties of Articular Cartilage Kazunori Yasuda Benjamin G Cooper, Brian D Snyder, Mark W Grinstaff Poster No. 0283 Poster No. 0274 C ontrolled Release Of Raav Vectors From Alginate- Real Time Assessment Of A New Hydrolytically poloxamer Complex Systems Degradable And Photo-clickable Hydrogel For Patricia Diaz-Rodriguez, Ana Rey Rico, Henning Madry, Cartilage Tissue Engineering Mariana Landin, Magali Cucchiarini Alexander J Neumann, Timothy Quinn, Stephanie Bryant PS1 Biomaterials - Bone

Poster No. 0275 Poster No. 0284 Superior Tribological Performance of Poly(vinyl Inflammatory Responses of Osteocytes to Mechanical alcohol) Hydrogels for Artificial Cartilage Perturbation and Wear Particles Teruo Murakami, Seido Yarimitsu, Kazuhiro Nakashima, Heon Goo Lee, Lee Song, Jungho Back, Francis Y Lee Tetsuo Yamaguchi, Yoshinori Sawae, Nobuo Sakai, Atsushi Suzuki Poster No. 0285 Does Locally Delivered Zoledronate Influence Poster No. 0276 Peri-implant Bone Formation? - Spatio-temporal 3d-printed ABS And PLA ScaffoldsF or Cartilage And Monitoring Of Bone Remodeling In Vivo Intervertebral Disc Tissue Regeneration Ulrike Kettenberger, Julien Ston, Eric Thein, Philip Procter, D erek H Rosenzweig, Eric Carelli, Thomas Steffen, Peter Dominique Pioletti Jarzem, Lisbet Haglund Poster No. 0286 Poster No. 0277 Enhanced Peri-implant Osteogenesis by Synthetic In Vitro Maturation and In Vivo Delivery of Cartilage Peptide Conjugation Repair Composites composed of Minced Cartilage in a Jeong Joon Yoo, Ji-Hye Lee, Jinwoo Nam, Soong Joon Lee, Photopolymerizable Hyaluronic Acid Hydrogel Hee Joong Kim Christian G Pfeifer, Anish G.R. Potty, Vishal Saxena, Alexander L. Neuwirth, Minwook Kim, Niobra M. Keah, Poster No. 0287 Rebekah S. Decker, Matthew B Fisher, Maurizio Pacifici, The Interactions Between BMP-2 and Hydrogel Robert L. Mauck Stiffness in Stimulating Bone Formation Shih Jye Tan, Josephine Fang, Zhi Yang, Marcel Nimni, Poster No. 0278 Bo Han Development of a Cartilage-interpenetrating Hydrogel POSTERS For Augmentation of Equilibrium and Time-dependent Poster No. 0288 Mechanical Properties Intraosseous Injections of rhBMP-2 Induces Periosteal A ndrea M Simi, Shikha Sharma, Benjamin G Cooper, Rachel Bone Formation in a Mouse Model of Osteogenesis C Stewart, Mark W Grinstaff, Brian D Snyder Imperfecta Tegan L Cheng, Aaron Schindeler, Craig M Munns, David G Poster No. 0279 Little Chondrogenic Differentiation Of Genetically Modified hMSC Via Controlled Release Of rAAV Vectors From Poster No. 0289 Self-assembling Peptide Hydrogels Spinal Fusion With Bone Morphogenetic Protein-2 Ana Rey Rico, Jagadeesh Venkatessan, Janina Frisch, Delivered by hydroxyapatite/collagen in a Rabbit Gertrud Schmitt, Amália Monge-Marcet, Alvaro Mata, Yasuda Hiroaki, Tomokazu Masaoka, Takashi Taniyama, Carlos Semino, Henning Madry, Magali Cucchiarini Tsuyoshi Yamada, Wei Xuetao, Toshitaka Yoshii, Atsushi Okawa, Shinichi Sotome Poster No. 0280 Ibuprofen Impairs Capsulolabral Healing in a Rat Poster No. 0290 Model of Anterior Glenohumeral Instability Enrichment of DBM with BMP-2: Burst Release Jonathan D Packer, Arya V Varthi, Frances Javier, David Combined with Long Term Binding Zhu, Jennifer V. Garver, Steven M Tommasini, Theodore A Nicole Bormann, Philipp Schwabe, Britt Wildemann Blaine

56 Poster No. 0291 Poster No. 0301 Osseoinductive, Osseoconductive And Antimicrobial Cell Behaviors on Grit-blasted Titanium Disc with Acrylate Hydrogel As Bone Graft Material or without Platelet-rich Plasma Pretreatment Nathanael G Morris, Stefano Perni, Polina Prokopovich Ji-H ye Lee, Jinwoo Nam, Soong Joon Lee, Hee Joong Kim, Jeong Joon Yoo Poster No. 0292 Elution Characteristics of PMMA Bone Cement Poster No. 0302 IM Spacers Impregnated with Vancomycin and The Effects Of Cobalt Chromium Molybdenum Surface Tobramycin Topography On Mesenchymal Stromal Cells In Vitro Andrew G Patton, Brandon A. Perez, William L. Buford, Jr. N iall Logan, Alison Traynor, Laurent Bozec, Peter Brett

Poster No. 0293 Poster No. 0303 Surface Construction Of Zn Doped Hydroxyapatite/ Effect Of Calcination Temperature On phase mgf2 Multilayer Coatings For The Biomedical Mg transformatiopn, Corrosion Resistance And Materials By A Novel Conversion/sol-gel Method Cytocompatibility Of CaP-coated Magnesium Heng Jui Liu, Da Jun Lin, Subhaini Jakfar, Fei Yi Hung, Materials For Orthopaedic Application Ming-Long Yeh Da-Jun Lin, Subhaini Jakfar, Fei-Yi Hung, Ming-Long Yeh

Poster No. 0294 Poster No. 0304 Implant Coating Technology with New Intramedullary Boron Containing Nano- Bioadhesive Materials Hydroxyapatite Bioceramic Application Improves Yohei Kagawa, Kentaro Yamane, Kensuke Shinohara, Bone Mineral Density, Volume and Surface of Noriyuki Watanabe, Aki Yoshida, Akihiro Matsukawa, Ovariectomized Rabbit Femurs Toshifumi Ozaki E da Çiftci, Feza Korkusuz, Petek Korkusuz, Hakan Hamdi Çelik, Alper Mehmet Çetinkaya Poster No. 0295 Implantation of an Osteoconductive Additive Poster No. 0305 Manufactured Titanium Alloy Implant Leads to Mesenchymal Stem Cell Response To Osteointegration Outside the Bone Envelope in Rats Uv-photofunctionalized Tio2 Coated Cobalt- and Rabbits chromium-molybdenum David J Cohen, Alexander Whitehead, Sharon L Hyzy, N iall Logan, Alison Cross, Alison Traynor, Laurent Bozec, Barbara D Boyan, Zvi Schwartz Ivan Parkin, Peter Brett

Poster No. 0296 Poster No. 0306 Engineerd Magnesium-based Resorbable Porous Is Nano-Rough Topography A Solution For Scaffold For Bone Tissue Engineering Enhanced And Stable Femoral Bone-Implant Hoi Man Wong, Paul K Chu, Frankie KL Leung, Kenneth MC Interface In A Hip Implant? Cheung, Keith DK Luk, Kelvin Wai Kwok Yeung S weetu B Patel, Farid Amirouche, Mathew Mathew, Tolou Shokuhfar Poster No. 0297 Collagen Plasma Treatment Of Poly-(ether-ether)- Poster No. 0307 ketone For Improved Outcomes Of Osseointegration Allograft Bone Tissue Reconstitution Time Jessica S Hayes, Seán Gaynard, Declan M Devine, Mary and Associated Compressive Strength: Murphy A Biomechanical Analysis M ark D Barton, Amir H. Qureshi, Loren Latta, Poster No. 0298 H. Thomas Temple Mechanical Properties of Rough and Surface Porous Polyether-ether-ketone Poster No. 0308 Na than Evans, David Safranski, F Brennan Torstrick, Development of a Novel Method for the Strengthening Christopher S.D. Lee, Kenneth M Dupont, W. Chang, Annie and Toughening of Irradiation-Sterilized Bone

Macedo, Jennifer Boothby, Angela Lin, Kenneth Gall Allografts used in Orthopaedic Reconstructions POSTERS Tarik Attia, Marc Grynpas, Thomas Willett Poster No. 0299 The Effects Of Hyaluronic Acid And Poly-d,l-lactic Acid Poster No. 0309 Coatings On Titanium Implant Fixation In Sheep Intramedullary Wire Fixation of Bone Allograft for Christina M Andreasen, Susan S. Henriksen, Ming Ding, Reconstruction of Critically-Sized Radius Segmental Thomas Levin Andersen, Soeren Overgaard Defect in a New Zealand White Rabbit Model S am Si-Hyeong Park, Kate Banks, Peter Salat, Adeline H Ng, Poster No. 0300 Christopher Kim, Marc Grynpas, Thomas Willett The Optimization of Porosity and Pore Patterning for Ti-6Al-4V Bone Constructs Using Additive Poster No. 0310 Manufacturing Cortical Bone Mimetic Matrix for Regeneration of Glenn Sanders, Matthew DiCaprio, Ronald Bucinell, Segmental Bone Defects Stephen A Paolicelli Danial Barati, Jeremiah T Easley, Ross H Palmer, Cecily Broomfield, Kirk McGilvray, EJ Ehrhart, Esmaiel Jabbari

57 Poster No. 0311 PS1 Cartilage, Synovium & Osteoarthritis - Combined Use of Platelet-rich Plasma (PRP) and Cell and Molecular Imaging Autologous Bone Grafts for Regeneration of Long Bone Critical-size Defects Poster No. 0320 Pascal Jungbluth, Johannes Schneppendahl, Simon Applying Three-Dimensional Confocal Imaging Thelen, Mohssen Hakimi, Joachim Windolf, Jan Grassmann to Study Articular Cartilage Minjie Zhang, S. Balaji Mani, Amber Hall, Lin Xu, Yefu Li, Poster No. 0312 David Zurakowski, Gregory Jay, Matthew Warman Fluid Shifts And Microvascular Blood Flow In The Tibia Using Body Tilt And Lower Body Negative Pressure Poster No. 0321 Jamila H Siamwala, Paul Lee, Brandon Macias, Alan 3-D Organization of Cells and Matrix in Human Hargens Articular Cartilage Neil Chang, Van Wong, Esther Cory, Felix Hsu, Robert Sah Poster No. 0313 WITHDRAWN Poster No. 0322 Contrast-enhanced μCT Arthrography (CE-μCTA) Poster No. 0314 Of Musculoskeletal Tissues In Mice Faster Bone Healing Can Be Achieved By Using a Bone Luis Cardoso, Daniel Leong, Hui Bin Sun Marrow Stem Cells Concentrate Glass-Reinforced Hydroxyapatite Scaffold: An In Vivo Ovine Study Poster No. 0323 Joao Torres, Manuel Gutierres, Luis Atayde, Paulo Cortez, Raman Spectrographic Characterization of Cartilage Maria Ascencao Lopes, Jose Domingo Santos, Abel Trigo Matrix Swelling via Lysyl Oxidase Inhibition in Cabral, Carola F van Eck Immature Explants and Tissue Constructs Krista M. Durney, Robert J Nims, Michael Albro, Tingyi Gu, PS1 Biomaterials - Tendon and Ligament Lucie Karbowski, Akaljot Singh, Sinisa Vukelic, Clark Hung, Gerard Ateshian Poster No. 0315 Effect of Two Terminal Sterilization Techniques Poster No. 0324 on the Functional Performance of Extracellular Pathological and MR Imaging Evaluation of Matrix Scaffolds Articular Cartilage Degeneration in the Gabriel S Perrone, Benedikt L. Proffen, Braden Fleming, Human Zygapophysial Joint Jakob Sieker, Joshua Kramer, Michael Hawes, Gary Badger, Daisuke Yamabe, Hideki Murakami, Hirooki Endo, Martha Murray Koou Choukan, Itsuko Tsukimura, Minoru Doita

Poster No. 0316 PS1 Cartilage, Synovium & Osteoarthritis - ACL Replacement Using a Decellularised Post Traumatic OA Xenograft Tendon Karin Hing, Gordon W Blunn Poster No. 0325 Serum Biomarkers In A Novel In Vivo Model Of Poster No. 0317 Post-traumatic Osteoarthritis Human Fascia Lata ECM Scaffold Augmented with Carin E Ahner, Aaron Stoker, Ferris Pfeiffer, Farrah Monibi, Immobilized Hyaluronan: Inflammatory Response and Seth Sherman, Chantelle Bozynski, James L Cook Remodeling in the Canine Body Wall and Shoulder Implantation Sites Poster No. 0326 Diane Leigh, Myung-Sun Kim, David Kovacevic, Andrew In vivo Evidence of a Shift in Tibiofemoral Contact in Baker, Carmela Tan, Anthony Calabro, Kathleen Derwin ACL-Reconstructed Knees During Dynamic Motion POSTERS Jarred Kaiser, Richard Kijowski, Geoffrey Baer, Poster No. 0318 Darryl Thelen Biomechanical Properties of an Artificial Ligament Produced from Demineralized Bone for Anterior Poster No. 0327 Cruciate Ligament Reconstruction IL-10 Reduces Apoptosis And Extracellular Matrix Anita Vijapura, Ali Alhandi, David Kaimrajh, Edward Milne, Degeneration After Injurious Compression Of Bovine Loren Latta, H. Thomas Temple Articular Cartilage Peter Behrendt, Andre Preusse-Prange, Alan J Grodzinsky, Poster No. 0319 Bodo Kurz Effect of Electron Beam Sterilization on the In Vivo Function of Extracellular Matrix Scaffolds Poster No. 0328 Gabriel S Perrone, Benedikt L. Proffen, Braden Fleming, Analysis of the Metabolic Response of Cartilage Tissue Jakob Sieker, Joshua Kramer, Michael Hawes, Gary Badger, to Injury and Inflammation in vitro Martha Murray Aaron Stoker, Kathleen James, Ferris Pfeiffer, Keiichi Kuroki, Chantelle Bozynski, James Cook

58 Poster No. 0329 Poster No. 0338 P38 Mitogen-activated Protein Kinase Regulates Lubricin/Proteoglycan 4 Binding to Cluster HDAC4 Degradation In Growth Plate Chondrocytes Determinant-44 (CD 44) Receptor and The Jingming Zhou, Pengcui Li, Qian Chen, Xiaochun Wei, Ting Contribution of Central Mucin Domain Glycosylations Zhao, Zhengke Wang, Lei Wei Maha Jamal, Tannin Schmidt, Gregory Jay, Khaled A Elsaid

Poster No. 0330 Poster No. 0339 Influence of ACL Reconstructive Surgery on Matrilin-3 Is An Inhibitor Of Angiogenesis In Vivo Tibiofemoral and Patellofemoral Kinematics: Linda H Chao, Samir K Trehan, Qian Chen A Dynamic MRI Study Jarred Kaiser, Arezu Monawer, Richard Kijowski, Poster No. 0340 Geoffrey Baer, Darryl Thelen Hyaluronidase Pre-treatment Inhibits Sox9 Expression Induced By Trpv4 Agonist Gsk1016790a Poster No. 0331 In Chondrogenic Atdc5 Cell The Correlation Of Cartilage Damage With Mechanical Yoshikazu Ogawa, Toshihisa Kojima, Nobunori Takahashi, Properties In Early Stages Of Osteoarthritis Using Toki Takemoto, Naoki Ishiguro A Mechanical Loaded Mouse Model Hongsik Cho, Yong-Hoon Jeong, Do-Gyoon Kim, PS1 Cartilage, Synovium & Osteoarthritis - Karen A Hasty Focal Defect Repair

Poster No. 0332 Poster No. 0341 Bone Morphological Changes Correlate with Reduction The Functional Assessment Of A Bi-layered Implant in PTA after Articular Fracture in the MRL/MpJ Mouse For The Repair Of Osteochondral Defects Kelly A Kimmerling, Bridgette D Furman, Tyler J Vovos, Tony Chen, Caroline Brial, Hongsheng Wang, Janet L Huebner, Virginia B Kraus, Farshid Guilak, Russell Warren, Suzanne Maher Steven A Olson Poster No. 0342 Poster No. 0333 Platelet-rich Plasma Impregnated Porous PVA Abnormal Mechanical Loading Induces Cartilage Scaffolds Improve Integration With Cartilage Explants Degeneration By Accelerating Meniscus Hypertrophy In A Dose-dependent Manner And Mineralization After Acl Injury In Vivo Tony Chen, Supansa Yodmuang, Kyra Caldwell, Guoqinq Du, Hongsheng Zhan, Shaowei Wang, Fangyuan Miguel Otero, Erik Attia, Russell Warren, Suzanne Maher Wei, Jianzhong Zhang, Xiaochun Wei, Anthony M Reginato, Braden C Fleming, Bahar Bilgen, Lei Wei Poster No. 0343 Detection and Characterization of Local Interfacial Poster No. 0334 Mechanics in a Cartilage Defect Repair Model Conditional And Cartilage-specific Expression Of Darvin Griffin, Amanda M Meppelink, Mark A Randolph, Mechanosensitive Microrna-365 Accelerates Meniscus Itai Cohen, Lawrence Bonassar Injury Induced Osteoarthritis In A Murine Model Rajiv J Iyengar, Kun Yang, Yun Gao, Zehong Yang, Wentian Poster No. 0344 Yang, Qian Chen Design and Fabrication of Minced Engineered Cartilage Fragments for Joint Repair Poster No. 0335 Andrea R Tan, Eben G Estell, Jack Farr, Christopher Ahmad, Characterization of Cartilage-specific IKKβ and IKKκ Gerard Ateshian, James L Cook, Clark Hung Inducible Knockout Mice in a Surgical Model of Osteoarthritis Poster No. 0345 Kirsty L Culley, Miguel Otero, Eleonora Olivotto, Jun Chang, Chondroprotection of Tissue-Engineered Cartilage Cecilia Dragomir, Kenneth B Marcu, Mary B Goldring via Internal Delivery of Dexamethasone Brendan L Roach, Arta Kelmendi-Doko, Elaine C Balutis, PS1 Cartilage, Synovium & Osteoarthritis - Matrix Brian K Jones, Gerard A Ateshian, Kacey G. Marra,

Proteins, Collagen and Proteoglycans Clark T Hung POSTERS

Poster No. 0336 Poster No. 0346 Galectin-3 Enhances Cartilage Lubrication Validation of Long-Term Preservation of via Lubricin Binding Osteochondral Allografts at Room Temperature Heidi L. Reesink, Edward D Bonnevie, Sherry Liu, Aaron Stoker, Clark Hung, Eric G Lima, James P Stannard, Lawrence Bonassar, Alan J Nixon James L Cook

Poster No. 0337 Poster No. 0347 The Anabolic Effects Of Hif-1κ-induced Hsp70 In Rabbit The Effect of Using Collagen Vitrigel Containing Articular Chondrocyte Under Hypoxic Conditions Transforming Growth Factor Beta 1 on Articular Shohei Ichimaru, Shinji Tsuchida, Yuji Arai, Shuji Nakagawa, Cartilage Repair Hiroaki Inoue, Tomohiro Matsuki, Kuniaki Honjo, Keiichiro Hideyuki Maruki, Masato Sato, Toshiaki Takezawa, Yoshiki Ueshima, Osam Mazda, Toshikazu Kubo Tani, Munetaka Yokoyama, Miyuki Kobayashi, Mami Kokubo, Tomoko Kawake, Rie Okada, Joji Mochida, Yoshiharu Kato 59 Poster No. 0348 Poster No. 0358 Influence of Photosensitizer Concentration and Impact Of The Synovial Fluid On Temperature Increase Irradiance on Articular Cartilage Bond Strength Due To Cartilage Viscoelastic Properties Alberto L Arvayo, Chun Hua Zheng, Michelle Deng, Mohamadreza Nassajian Moghadam, Philippe Abdel- Marc Levenston Sayed, Valérie Malfroy Camine, Dominique P Pioletti

PS1 Cartilage, Synovium & Osteoarthritis - Mechanics Poster No. 0359 Relevance of the Spatial Distribution Pattern of Poster No. 0349 Mechanical Properties of Articular Cartilage in Boundary Lubrication by Synovial Fluid in TMJ Disc Animal Studies and Condylar Cartilage Sotcheadt Sim, Insaf Hadjab, Martin Garon, Hunter Bachman, Brandon K Zimmerman, Eric J Granquist, Eric Quenneville, Michael D Buschmann David L Burris, X. Lucas Lu PS1 Cartilage, Syovium & Osteoarthritis - Gene Therapy Poster No. 0350 Deleterious Effects of Blood on Cartilage Lubrication Poster No. 0360 by Synovial Fluid: Friction and Wear are Impaired Improved Conditions To Enhance The Chondrogenic but not Correlated Differentiation Processes In Human Primary Bone Michele M Temple-Wong, Ellie A Hofer, Haoran Qiu, Marrow Aspirates Via rAAV-mediated Gene Transfer Robert L Sah Ana Rey Rico, Janina Frisch, Jagadeesh Venkatessan, Gertrud Schmitt, Henning Madry, Magali Cucchiarini Poster No. 0351 Customized Osteochondral Grafts for Cartilage Poster No. 0361 Resurfacing: Effects of Contour and Placement on Enhanced Chondrogenic Differentiation Processes Biomechanics of Femoro-Tibial Contact in the Goat In Bone Marrow Aspirates From Minipigs Following Jason P Caffrey, Bradley C Hansen, Kristina L Shia, Daniel rAAV-mediated Gene Transfer And Overexpression P Arnold, Karen E Samy, Albert C Chen, Esther Cory, Shyni Of The Transcription Factor Sox9 Varghese, Koichi Masuda, William D Bugbee, Robert L Sah Janina Frisch, Ana Rey-Rico, Jagadeesh K Venkatesan, Gertrud Schmitt, Henning Madry, Magali Cucchiarini Poster No. 0352 Sprifermin (rhFGF18) Preserves Articular Cartilage Poster No. 0362 Depth-Dependent Properties During in Vitro Culture Influence Of IGF-I Overexpression Via rAAV Gene Gregory R Meloni, Alexandra Farran, Bhavana Mohanraj, Transfer Upon The Chondrogenic Differentiation Anne Gigout, Robert L Mauck, George R Dodge Potential Of Human Bone Marrow Aspirates Janina Frisch, Ana Rey-Rico, Jagadeesh K Venkatesan, Poster No. 0353 Gertrud Schmitt, Henning Madry, Magali Cucchiarini Cartilage Deformation in ACL-Deficient Knees: A Dynamic In Vitro Model Poster No. 0363 Justin W Arner, James N. Irvine, Liying Zheng, Margaret Effect Of Inhibiting Mmp13 And Adamts5 Small Hankins, Robert E. Carey, Eric D Thorhauer, Scott Tashman, Interference Rna (sirna) By Intra-articular Injection Christopher D Harner, Xudong Zhang In A Surgically Induced Osteoarthritis Model Of Mice Hiroko Hoshi, Takahisa Sasho, Ryuichiro Akagi, Yuta Poster No. 0354 Muramatsu, Yorikazu Akatsu, Joe Katsuragi, Taisuke Mechanically Aided Transport of Antibodies Fukawa through Articular Cartilage Chris DiDomenico, Zhen Xiang Wang, Lawrence Bonassar PS1 Cartilage, Synovium & Osteoarthritis - Matrix POSTERS Degradation Poster No. 0355 Subject-Specific 3D T2 Relaxation Mapping Of The Poster No. 0364 Tibiofemoral Cartilage Contact Regions During Detection of Elevated CTXII Levels within the Knee Walking: A Dual Fluoroscopy And Magnetic Resonance Joint of a Rat Monoiodoacetate OA Model using a Imaging Approach Novel Magnetic Capture Technique Gulshan B Sharma, Gregor Kuntze, Jillian E Beveridge, Elena G Yarmola, Yash Shah, David P. Arnold, Jon Dobson, Chris Bhatla, Richard Frayne, Janet L Ronsky Kyle D Allen

Poster No. 0356 Poster No. 0365 Fabella Size: A Marker for Specific Compartment Multi-scale Delineation of Articular Cartilage Osteoarthritis and Mechanics Deterioration in Aging and Osteoarthritis Douglas D Robertson, Jr., Elie Harmouche, Jad Chamieh, Neil Chang, Esther Cory, Albert C Chen, Martin K Lotz, Walter Carpenter, Michael Terk, Scott A Banks Robert Sah

Poster No. 0357 Poster No. 0366 Contrast Agent’s Transport Across Healthy Articular In vitro Degradation and In Vivo Deterioration Analysis Cartilage Under Various Bath Conditions of a Bioluminescent Cartilage Reporter Mouse Model Behdad Pouran, Vahid Arbabi, Joaquin Villamar, Amir Sarah Mailhiot, Garcia Allen, Donald Zignego, Ronald June Abbas Zadpoor, Harrie Weinans 60 Poster No. 0367 Poster No. 0375 Intra-articular Injection Of Rebamipide Prevents Comparison and Characterization of In Vitro and Articular Cartilage Degeneration In Murine Models In Vivo Treatments of Lubricin-Mimetics on Of Osteoarthritis Articular Cartilage Yoshiaki Suzuki, Masahiro Hasegawa, Yuriyo Matsui, Kirk J Samaroo, Mingchee Tan, Marco Demange, Ashley Hironori Unno, Takahiro Iino, Toshimichi Yoshida, Titan, Camila Carballo, Marco Sisto, Scott Rodeo, David Akihiro Sudo Putnam, Lawrence Bonassar

Poster No. 0368 Poster No. 0376 Low Dosage Of Monoiodoacetic Acid Induces TGF-β induced Synergy Between Chondrocytes and Arthritis Without Bone Defect In A Rat Model Stem Cells for Articular Cartilage Repair In Vivo Mio Udo, Ichiro Sekiya, Kunikazu Tsuji, Nobutake Ozeki, Janice H Lai, Lisa Su, R Lane Smith, William Maloney, Yusuke Nakagawa, Toshiyuki Ohara, Ryusuke Saito, Fan Yang Katsuaki Yanagisawa, Takeshi Muneta Poster No. 0377 PS1 Cartilage, Synovium & Osteoarthritis - Tissue Enzymatically Treated Adult Cartilage Fragments for Engineering and Repair Cartilage Regeneration - Is Fibrin Glue Appropriate for Cartilage Repair? Poster No. 0369 Alex J McNally, Jennifer Van Deven, Chris Chapman, Active: Preliminary Results At 5 Years Of A Randomized Steve Lin, Kurt Sly Trial Of Autologous Chondrocyte Implantation In The Knee Where Previous Surgery Has Failed Poster No. 0378 James B Richardson, Jan Herman Kuiper, Martyn Snow, Hypoxia Enhances Colony Formation And Proliferation Hamish Simpson With Chondrogenic Potential In Passage 0 Human Synovial Mesenchymal Stem Cells Poster No. 0370 Toshiyuki Ohara, Takeshi Muneta, Yu Matsukura, IdentificationO f Prognostic Biomarkers For Kunikazu Tsuji, Ichiro Sekiya Autologous Chondrocyte Implantation In Cartilage Repair Poster No. 0379 Karina T Wright, James B Richardson, Heidi Fuller, Sally Unraveling Chondrocyte and MSC Cocultures: Roberts Direct Cell-Cell Contact is Essential for Optimal Cartilage Regeneration Poster No. 0371 Tommy S de Windt, Daniel B Saris, Ineke C Slaper- Cartilage Regenerative Capacity of Amnion-derived Cortenbach, Mattie H van Rijen, Wouter J Dhert, ECM-coated PLGA Scaffold in aC artilage Defect Lucienne A Vonk Model in Nonhuman Primates Makiko Nogami, Shoji Seki, Hiraku Motomura, Ryuichi Poster No. 0380 Gejo, Hiroto Makino, Toshio Nikaido, Tomoatsu Kimura Towards an Extracellular Matrix Based, In-situ Crosslinkable Scaffold for Cartilage Repair Poster No. 0372 Emma Cavalli, Claudia Loebel, David Eglin, Scaffold-free Cell-matrix Bead-type Autologous Marcy Zenobi-Wong Chondrocyte Implantation, Cartilifetm For Cartilage Repair: Early Clinical Results Poster No. 0381 Kee Yun Chung, Sahnghoon Lee, Jungsun Lee, Jin-Yeon O ptimization of a Novel Scaffold for Cartilage Repair Lee, Byung-Chul Chae, Youngsook Son, Kyoung Ho Yoon, Sarav Shah, Sandeep Pandit, Z Parikh, John A. Schwartz, Myung Chul Lee Todd A Goldstein, L.P. Lavelle, Arindam Datta, Haixiang Liang, Daniel Grande Poster No. 0373 The Repair Of Articular Cartilage Defects Using A Poster No. 0382 Transglutaminase 4 And Hydrogel Embedded With WITHDRAWN

Synovium-derived Stem Cells In Rabbit Model POSTERS Hyunjin Min, Sun Young Wang, Hee Jung Park, Yu Jung Poster No. 0383 Kim, Kee Yun Chung, Hyuk Soo Han, Sahnghoon Lee, T reatment of Cartilage Defects With 3D Bio-Printed Myung Chul Lee Scaffolding Todd A Goldstein, Benjamin Smith, John A. Schwartz, Poster No. 0374 Jonathan Berkowitz, Daniel Grande Repair Of Chronic Osteochondral Defect Using Magnetically Labeled Mesenchymal Stem Cells Poster No. 0384 Elhussein Elbadry Mahmoud, Goki Kamei, Yohei Harada, Enhanced Expression of Type II Collagen with a Naosuke Kamei, Nobuo Adachi, Mitsuo Ochi Micronized Cartilage Matrix and Platelet Derived Growth Factor James R Mullen, Kevin Myers, Zalak Parikh, Haixiang Liang, Daniel Grande

61 Poster No. 0385 Poster No. 0395 Magnetic Targeting of Chondrocyte Sheet The Effect On Articular Cartilage Repair Using for the Treatment of Osteoarthritis Collagen Vitrigel And Chondrocyte Sheets Seiju Hayashi, Yasunari Ikuta, Ryo Shimizu, Naosuke Kamei, Yoshiki Tani, Masato Sato, Toshiaki Takezawa, Nobuo Adachi, Masataka Deie, Mitsuo Ochi Munetaka Yokoyama, Miyuki Kobayashi, Eriko Toyoda, Tomoko Kawake, Eri Okada, Joji Mochida Poster No. 0386 Age Independent Cartilage Generation for Synovium PS1 Cartilage, Synovium & Osteoarthritis - Genetics/ Based Autologous Chondrocyte Implantation Genomics and Proteomics Nahoko Shintani, Marius J.B. Keel, Kurt Lippuner, Ernst B Hunziker Poster No. 0396 Depletion Of GD3 Synthase Enhances Poster No. 0387 Osteoarthritis Development In Mice Tissue Engineered Human Cartilage Sheets Dausuke Momma, Tomohiro Onodera, Fumio Sasazawa, are Significantly Stiffer When Re-Differentiated Masatake Matsuoka, Shinji Matsubara, Norimasa Iwasaki at Low Oxygen Tension Thomas J Kean, G A Whitney, Geoff Traeger, Poster No. 0397 Russell J Fernandes, James E Dennis A Transcriptomic and Proteomic Analysis of Acute Changes in a Pig Model of Post-Traumatic Poster No. 0388 Osteoarthritis Physical Forces Modulate the Tissue Engineered Ugur M Ayturk, Carla M Haslauer, Tue Bennike, Jakob T Cartilage Ultrastructure Sieker, Benedikt L. Proffen, Matthew L Warman, Braden C Erica Kahn, Amy X Mei, Robert Stefani, Carol Ayala, Fleming, Martha M Murray Roy K Aaron, Bahar Bilgen Poster No. 0398 Poster No. 0389 Endoplasmic Reticulum Stress-induced Apoptosis Chondrogenic Differentiation Of Bone Marrow- Contributes To Articular Cartilage Degeneration derived Mesenchymal Stem Cells Regulated By Via C/EBP Homologous Protein Wnt/beta-catenin Signaling Pathway Yusuke Uehara, Jun Hirose, Hiroshi Mizuta Peng Cheng, Anmin Chen, Fengjing Guo, Hui Huang, Qing Yang, Weikai Zhang Poster No. 0399 Genome-wide MicroRNA Expression Profiling And Poster No. 0390 Pathway Analysis Reveal Progressive Changes In D ynamic Axial Loading Disrupts Lateral Integration Epidermal Growth Factor Signaling In Experimental of Arthritic Human Articular Cartilage and Synthetic Osteoarthritis Tissue Engineered Scaffolds in an Ex Vivo Ring Model Paul J Fanning, Christopher Raskett, Yukiko Maeda, Benjamin R Mintz, Dean Papaliodis, Smelker Jordan, Nicholas Farina, Ellen Gravallese, Gary Stein, Janet Stein, Garrett Leonard, Michael Mulligan, James A Cooper David Ayers, Jane Lian

Poster No. 0391 Poster No. 0400 Kartogenin Enhance Chondrogenic Differentiation of Deletion of the PH-domain and Leucine Rich Repeat MSCs in 3-D Tri-copolymer Scaffold and Functional- Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Closed Perfusion System Growth Factor (Fgf) 18 Expression and Protects Chun-Ching Li, Ching-Yun Chen, Cherng-Jyh Ke, Feng-Hui Against Surgically-Induced Osteoarthritis Lin, Jui-Sheng Sun Elizabeth W. Bradley, Meghan E McGee-Lawrence, Lomeli R. Carpio, Derek F. Amanatullah, Sanjeev Kakar, Lauren E. POSTERS Poster No. 0392 Ta, Alexandra C. Newton, Jennifer J. Westendorf MIAMI Cell hyaline cartilage formation is enhanced by TGF-β3-Releasing Pharmacologically Active PS1 Cartilage, Synovium & Osteoarthritis - Growth Plate Microcarriers And Human Cartilage Microparticles and Endochondral Ossification Gaetan J Delcroix, Gianluca D’Ippolito, Teresita Reiner, Theodore Malinin, H. Thomas Temple, Claudia N Poster No. 0401 Montero-Menei, Paul C Schiller Meclozine, Motion Sickness Medicine, Has The Therapeutic Potential In Achondroplasia Poster No. 0393 Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Development Of An Ex-vivo Organ Culture Yoshihiro Nishida, Naoki Ishiguro, Kinji Ohno Model Of The Femoral-tibial Joint Natalie Fox, Martin Stanley, Daniel S Thomas, John Fisher, Poster No. 0402 Eileen Ingham L oss Of Tet1 Impairs Endochondral Ossification In The Embryonic Growth Plate Poster No. 0394 Piera Smeriglio, Sarah E. B. Taylor, Madhusikta Rath, D evelop Surface Treated Biphasic Poly Nidhi Bhutani (lattice-co-glycolic) Acid (PLGA) Scaffold to Maintain Chondrocyte Phenotype and Interface Integration Meng-Chian Wu, Wen-Hui Cheng, Hsueh-Chun Wang, Tzu- Hsiang Lin, Jhih-Jhan Lin, Horng-Chaung Hsu, Ming-Long 62 Yeh Poster No. 0403 Poster No. 0413 Promoting Endogenous Repair in a Rat Growth Plate The Role of Prenatal Movements in Injury Model by Enhancing Mesenchymal Stem Cell Promoting Postnatal Hip Joint Stability Recruitment and Chondrogenesis Mario Giorgi, Alessandra Carriero, Niamh C. Nowlan, Nichole Shaw, Michelle Sauque, Michael S Riederer, Sandra Shefelbine Nancy Hadley-Miller, Melissa D Krebs, Karin A Payne Poster No. 0414 Poster No. 0404 How Does The Actin Cytoskeleton Modulate The Zonal and Regional Variations in Growth Plate Local Elastic And Time-dependent Properties Of Chondrocyte Deformation under Compression Chondrocytes During AFM Nanoindentation? as Predicted by 3D Multiscale Simulations Cristina Florea, Mika E Mononen, James M Fick, Janne Jie Gao, Esra Roan, John L Williams Ylärinne, Cheng J Qu, Mikko J Lammi, Rami K Korhonen

Poster No. 0405 Poster No. 0415 Bone-Like Microenvironment Induces Hypertrophy Morphology Of Chondrocytes Within Articular in Phenotypically Stable Nasal Chondrocytes Cartilage AffectsT he Solid But Not The Fluid Melika Sarem, Andrea Barbero, Neha Arya, Ivan Martin, Microenvironment Under Compression V. Prasad Shastri Hongqiang Guo, Suzanne Maher, Peter Torzilli

Poster No. 0406 PS1 Cartilage, Synovium & Osteoarthritis - Cytokines, Characterization Of A 3d Model Of Mineralization Inflammation In Atdc5 Cells Biming Wu, Rhima M Coleman Poster No. 0416 A Smart Aptamer Facilitates The Conjugated-Triptolide Poster No. 0407 Selectively Targeting Joint To Enhance Efficacy And Growth Plate Chondrocyte Biomechanics and Reduce Hepatotoxicity In Mice Mechanobiology: A Multi-Scale Study Biao Liu, Junzhe Huang, Jun Lu, Defang Li, Xiaojuan He, Jie Gao, Esra Roan, John L Williams Ge Zhang, Aiping Lu

PS1 Cartilage, Synovium & Osteoarthritis - Poster No. 0417 Mechanobiology Bmp-2 Stimulation Works In A Cox-2 Dependent Manner To Promote Chondrocyte Maturation Poster No. 0408 Jessica Cottrell, James O’Connor A Novel Mechanism of Chondrocyte Death in Cartilage Subjected to Extreme Loads Poster No. 0418 Alexander Kotelsky, Andrea Lee, Mark Buckley S ynovial Macrophages Promote TGF-β Activation After Intra-Articular Injections of Oxidized LDL in Poster No. 0409 Naïve Murine Knee Joints, Preventing Production of Age Dependent Cartilage Repair and Subchondral Pro-Inflammatory Factors S100A8/9, Chemokines and Bone Remodeling in a Minipig Defect Model Aggrecanase-Induced Neo-Epitopes Christian G Pfeifer, Matthew B Fisher, Vishal Saxena, Wouter de Munter, Arjen B Blom, Peter M van der Kraan, Minwook Kim, Elizabeth A. Henning, George R Dodge, Johannes Roth, Thomas Vogl, Wim B van den Berg, David R. Steinberg, Robert L. Mauck Peter L van Lent

Poster No. 0410 Poster No. 0419 Flux Calculations Based on Metabolomic Data for N otch1 Negatively Mediates Mesenchymal Progenitor Human Chondrocyte Central Energy Metabolism in Cell Chondrogenic differentiation Mainly through Response to Applied Compression Up-Regulation of Twist1 Daniel Salinas, Cody Minor, Ross Carlson, Brendan Mumey, Bo Tian, Yongjun Wang, John Marymont, Yufeng Dong Ronald June

Poster No. 0420 POSTERS Poster No. 0411 T he Role Of The Tetraspanin CD9 In A Mouse Model Of Mechano-regulation Of NFATc In Articular Cartilage Antigen-induced Arthritis Ayesha Al-Sabah, Vic Duance, Emma Blain Norihiko Sumiyoshi, Shigeru Miyaki, Hiroyuki Ishitobi, Tomoyuki Nakasa, Kenji Miyado, Mitsuo Ochi Poster No. 0412 O a Chondrons: A Biosynthetically Active Cell Poster No. 0421 Population Capable Of Responding To Biomechanical P rogranulin Protects Against Osteoarthritis Loads Within The Implant Through Interacting With Tnf-κ And β-catenin Miriam Rothdiener, Tatiana Uynuk-Ool, Tino Felka, Signaling Pathway Bjoern Gunnar Ochs, Ulrich Stoeckle, Alan J Grodzinsky, Jianlu Wei, Yunpeng Zhao, Qingyun Tian, Chuanju Liu Bernd Rolauffs Poster No. 0422 S alubrinal Suppresses Cartilage Degeneration in a Murine Knee Osteoarthritis Model Akinobu Nishimura, Kazunori Hamamura, Masahiro Hasegawa, Akihiro Sudo, Hiroki Yokota 63 Poster No. 0423 PS1 Cartilage, Synovium & Osteoarthritis - Aging High Systemic LDL Cholesterol Levels during Experimental Osteoarthritis Lead to Increased Poster No. 0432 Synovial Activation and Ectopic Bone Formation at Proteomic Analysis Of Mesenchymal Stem Cell Ageing End-Stage Osteoarthritis, While Excessive Levels And Their Musculoskeletal Differentiation Accelerate Development of Joint Pathology Already Mandy J Peffers, John Collins, Peter D Clegg at Early-Stage Osteoarthritis Wouter de Munter, Martijn H van den Bosch, Annet W Poster No. 0433 Sloetjes, Peter M van der Kraan, Thomas Vogl, Johannes Methylation Profiling Of Mesenchymal Stem Cells And Roth, Wim B van den Berg, Peter L van Lent Their Musculoskeletal Differentiation With Ageing Mandy J Peffers, John Collins, Peter D Clegg Poster No. 0424 Interaction With Macrophages Attenuates Fibroblast- Poster No. 0434 like Synoviocyte Adamts5 (aggrecanase-2) Gene Effect of Osmotic Stress on Intracellular Calcium Expression Following Inflammatory Stimulation Signaling of In Situ Juvenile and Mature Chondrocytes Rhiannon E Morgan, Peter D Clegg, John A Hunt, Yilu Zhou, Michael A. David, Jie Ma, Liyun Wang, Simon R Tew X. Lucas Lu

Poster No. 0425 Poster No. 0435 Characterization of a Model System to Study Synovial Comprehensive Transcriptome Analysis of Aging- Membrane Transport Properties related Change in Early Phase of Post-traumatic Robert Stefani, Andrea R Tan, Adam B Nover, Osteoarthritis J Chloe Bulinski, Gerard Ateshian, Clark Hung Tomoaki Fukui, Alesha B Castillo, Ashley Russell, Jasper HN Yik, Dominik R Haudenschild Poster No. 0426 Cdk9 Inhibitors Preserve the Mechanical Properties PS1 Cartilage, Synovium & Osteoarthritis - of Osteochondral Explants After Prolonged Storage Osteoarthritis - Therapies Jasper Yik, Nina Liu, Kie Shidara, Derek Cissell, Kyriacos A Athanasiou, Dominik R Haudenschild Poster No. 0436 C annabinoid Receptor Expression in OA cartilage Poster No. 0427 Sara L Dunn, Aileen Crawford, J Mark Wilkinson, Rowena Endocannabinoid Anandamide and Fatty Acid Amide A.D Bunning, Christine L Le Maitre Hydrolase Inhibitor URB597 Prevent Interleukin- 1β-Induced Cartilage Degradation While Enhancing Poster No. 0437 Mesenchymal Stem Cell Chondrogenesis T hermally Responsive Pluronic-Chitosan-Small Stephen D Thorpe, Aoife Gowran, Jung H Kim, David A Lee Molecular Drug Conjugated Nanocapsules with Controlled Dual Release for Combined Therapy of Poster No. 0428 Osteoarthritis L ow-Dose Preconditioning of Engineered Cartilage Mi Lan Kang, Ji Eun Kim, Gun-Il Im with Interleukin-1κ Provides Sustained Protection Against Subsequent Cytokine Exposure Poster No. 0438 Andrea R Tan, Mukundan Attur, Steven Abramson, Martin Intra-articular Injection Of Magnesium Chloride M Knight, J Chloe Bulinski, Gerard Ateshian, Clark T Hung (MgCl2) Attenuates The Progression Of Osteoarthritis Through Suppressing The Expression Of Nucleostemin Poster No. 0429 Jerry Jiankun Xu, Yifeng Zhang, Jiali Wang, Kelvin Ho, Effects of Oxidized Low Density Lipoprotein on Bruma Saichuen Fu, Kaiming Chan, Ling Qin POSTERS an in vitro Model of Canine Osteoarthritis Keiichi Kuroki, Chris Kennedy, Aaron Stoker, James L Cook Poster No. 0439 S ynergistic Regulation of Chondrocytes by Progranulin Poster No. 0430 Growth Factor and Low Intensity Pulsed Ultrasound The Neuropeptide Substance P Suppresses Articular Sardar Muhammad Zia Uddin, Chuanju Liu, Brendon Chondrocyte Differentiated Activity Richbourgh Yurong Ouyang, Juan Taboas Poster No. 0440 Poster No. 0431 Flavopiridol Restores Global Metabolome in Symptomatic Characterization Of Animal Model Mouse Post-Traumatic Ostearthritis With Lumber Facet Joint Osteoarthritis Induced By Ronald June, Dominik R Haudenschild, Donald Zignego, Non-invasive Needle Puncture Ziang Hu, Jasper Yik Jae-Sung Kim, Jeffrey Kroin, Hong-Moon Sohn, Jae-Won You, Sang Soo Park, Dahye Oh, In-A Cho, Kyeong-Rok Poster No. 0441 Kang, Sook-Young Lee, Do Kyung Kim, Chun Sung Kim, Green Tea Polyphenol Treatment Is Chondroprotective, Su-Gwan Kim, Hee-Jeong Im Anti-inflammatory AndP alliative In A Mouse Post-traumatic Osteoarthritis Model Daniel Leong, Marwa Choudhury, Regina Hanstein, Lin Xu, David Hirsh, Sun J Kim, Robert J. Majeska, Mitchell B Schaffler, John A Hardin, David Spray, Mary B Goldring, 64 Neil Cobelli, Hui Bin Sun Poster No. 0442 Poster No. 0451 Intra-articular Delivery of Kartogenin Conjugated Induced Pluripotent Stem Cells Derived From Human Chitosan Nano/microparticles for Cartilage Repair Articular Chondrocytes Are A Source Of Chondrogenic Mi Lan Kang, Ji-Yun Ko, Ji Eun Kim, Gun-Il Im Progenitor Cells Rosa M. Guzzo, Hicham Drissi PS1 Cartilage, Synovium & Osteoarthritis - Osteoarthritis - Clinical Poster No. 0452 The Effects of Constant Hypoxia on the Expansion and Poster No. 0443 Differentiation Of Human Mesenchymal Stem Cells Correlations between Patient Reported Outcome Marcel Betsch, Regina Wehrle, Brian Johnstone and Gait Alterations Pre- and Post- Anterior Cruciate Ligament Reconstruction PS1 Meniscus - Mechanics Aisia R Azus, Hsiang-Ling Teng, Lauren Tufts, Benjamin Ma, Richard Souza, Xiaojuan Li Poster No. 0453 Alterations in Regional Loading Patterns on Articular Poster No. 0444 Cartilage Following Meniscectomy and Meniscal Effect Of Obesity And Vitamin E On Mitochondrial Transplantation Function In Human Chondrocytes Hongsheng Wang, Tony Chen, Albert O Gee, Ian D Saran Tantavisut, Mitchell C Coleman, James A Martin, Hutchinson, Kirsten Stoner, Russell Warren, Scott Rodeo, John Callaghan Suzanne Maher

Poster No. 0445 Poster No. 0454 Strenuous Running Enhances Degeneration Evaluation of Meniscal Extrusion with Posterior Root Of Articular Cartilage In A Rat Mia-induced Disruption and Repair using Ultrasound Arthritis Model Grant M Rowland, Damon E Mar, Stephanie Nance, Ryusuke Saito, Ichiro Sekiya, Nobutake Ozeki, Yusuke Terence E McIff, Gary W Hinson, Joshua D Nelson Nakagawa, Mio Udo, Katsuaki Yanagisawa, Kunikazu Tsuji, Takeshi Muneta Poster No. 0455 An Anteriorized Posterior Root Position Does Not Poster No. 0446 Alter Lateral Meniscal Transplant Kinematics When A Prospective Evaluation of Three Serum Biomarkers Compared To Anatomic Root Placement in Hip Arthroscopy Patients and Matched Controls Philip C Noble, Hugh Jones, Andrea Gale, Michael Hogen, Austin V. Stone, Christopher Stem, Elizabeth A Howse, Jason Alder, Patrick McCulloch Allston J. Stubbs Poster No. 0456 PS1 Cartilage, Synovium & Osteoarthritis - Progenitors E ffect of Intramedullary Tibial Nailing on Attachment and Stem Cells Area and Ultimate Strength of the Anterior Medial Meniscal Root: Is the Safe Zone Really Safe? Poster No. 0447 Matthew D LaPrade, Christopher M LaPrade, After Repeated Division, Bone Marrow Stromal Mark G. Hamming, Michael B Ellman, Travis L Turnbull, Cells Express Inhibitory Factors With Osteogenic Matthew T Rasmussen, Robert F LaPrade, Coen A Wijdicks Capabilities, And Epha5 Is A Primary Candidate. Tsuyoshi Yamada, Shinichi Sotome, Toshitaka Yoshii, Poster No. 0457 Atsushi Okawa 3D Meniscal Kinematics and Deformation with Knee Flexion and Loading: A Novel In-Vivo MRI Poster No. 0448 Study of the Knee In Vivo Kinetics of Mesenchymal Stromal Cell Daniel Watling, David Williams, Gemma M Whatling, Transplanted into The Knee Joint in A Rat Model – Cathy A Holt In Vivo Fluorescence Imaging and 3D Computed Tomographic Evaluation Poster No. 0458

Yasunari Ikuta, Naosuke Kamei, Masakazu Ishikawa, Meniscal and Tibio-femoral Kinematics POSTERS Mitsuo Ochi after Meniscal Transplantation Philip C Noble, Donald Dulce, Hugh Jones, Andrea Gale, Poster No. 0449 Michael Hogen, Jason Adler, Patrick McCulloch Comparison Of The Immunosuppressive Properties Of Allogeneic And Autologous Equine Bone Marrow PS1 Meniscus - Biology and Repair Derived Mesenchymal Stem Cells Aimee C Colbath, Jennifer N Phillips, Frank Barry, Poster No. 0459 C Wayne McIlwraith, Steven Dow, Laurie R Goodrich B iodegradable Tissue Glues For Meniscus Tears Agnieszka I Bochynska, Tony G van Tienen, Gerjon Poster No. 0450 Hannink, Pieter Buma, Dirk W Grijpma Inflammatory Suppression of Galectins Decreases Mesenchymal Stem Cell Adhesion and Motility Heidi Reesink, Carolyn Shurer, Michael Davidson, Alan Nixon

65 Poster No. 0460 Poster No. 0469 PLLA Fiber-Reinforced Scaffold forT otal Anterior Cruciate Ligament (ACL) Derived Stem Cells Meniscus Replacement in an Ovine Model Transduced Ex-vivo with BMP2 Accelerates Tendon- Jay M Patel, Aaron R Merriam, Michael G Dunn, Bone Healing in ACL Reconstruction Charles J Gatt Yohei Kawakami, Makoto Kobayashi, Ying Tang, Bing Wang, Koji Takayama, Yutaka Mifune, Tomoyuki Poster No. 0461 Matsumoto, James Cummins, Ryosuke Kuroda, Effect Of Centralization For Extruded Masahiro Kurosaka, Freddie H Fu, Johnny Huard Meniscus Extrusion In A Rat Model Kenichi Kawabata, Nobutake Ozeki, Hideyuki Koga, Poster No. 0470 Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Katsuaki Biological Augmentation of Rotator Cuff Repair with Yanagisawa, Toshiyuki Ohara, Kunikazu Tsuji, Takeshi Endothelial Progenitor Cells Muneta, Ichiro Sekiya Tony Lin, Erica Giles, Michael Glick, Charles Godbout, Sarah Ketcheson, Vladimir Iakovlev, Emil H Schemitsch, Poster No. 0462 Aaron Nauth The Effect Of Fibrin Clot Derived From Bone Marrow On Human Meniscal Healing In An Poster No. 0471 Organ Culture Model Cited2 Is A Principal Regulator Of Telomerase Takeshi Shoji, Tomoyuki Nakasa, Naosuke Kamei, Expression, A Representative Feature Of A Functionally Takuma Yamasaki, Yuji Yasunaga, Mitsuo Ochi Active Tendon Stem Progenitor Cell Population Fawzy Saad, Daniel Leong, Zhiyong He, Lin Xu, Robert J. Poster No. 0463 Majeska, Tony S. Wanich, Konrad Gruson, Evan L Flatow, A Novel Approach to Tissue Engineering Hui Bin Sun Meniscus to Bone Interface Mary Clare McCorry, Daniel Coppola, Jonathan Lee, PS1 Tendon/Ligament - Repair and Tissue Engineering Lawrence Bonassar Poster No. 0472 Poster No. 0464 Platelet Rich Plasma Protects Rat Achilles Tendon From Region-SpecificE ffect of Decellularized Meniscus The Deleterious Effects Of Steroid Extracellular Matrix on Mesenchymal Stem Tomoyuki Muto, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Cell-Based 3D Meniscus Tissue Engineering Inui, Yoshifumi Harada, Fumiaki Takase, Yassuhiro Ueda, Kazunori Shimomura, Benjamin B Rothrauff, Rocky S. Tuan Masahiro Kurosaka

Poster No. 0465 Poster No. 0473 Matrix Microstructure and Micromechanics Influence Exogenous Administration Of Fibroblast Growth the Repair Potential of the Knee Meniscus Factor-2 Enhances The Expansion Of A Tenogenic Feini Qu, Michael P Pintauro, John L Esterhai, Progenitor Cell Population In A Rat Rotator Cuff Matthew B Fisher, Robert L Mauck Repair Model Takuya Tokunaga, Junji Ide, Hiroshi Mizuta Poster No. 0466 Concurrent Lateral Meniscal Repair and Anterior Poster No. 0474 Cruciate Ligament Reconstruction Significantly A Canine Non-Weight-Bearing Model with Increases the Lateral Meniscal Width Percentage Radial Neurectomy for Rotator Cuff Repair and Extrusion Xiaoxi Ji, Nirong Bao, Kai-Nan An, Peter C Amadio, Naoko Kashihara, Takayuki Furumatsu, Shinichi Miyazawa, Scott P Steinmann, Chunfeng Zhao Takaaki Tanaka, Masataka Fujii, Hiroto Inoue, Toshifumi POSTERS Ozaki Poster No. 0475 R otator CuffR epair Augmentation in a Rat Model with PS1 Tendon/Ligament - Progenitors and Stem Cells Use of a Combination of Multilayer Xenograft Tendon Scaffold and Bone Marrow Stromal Cells Poster No. 0467 Rei Omi, Anne Gingery, Scott P Steinmann, Peter C Biceps Tendon Tenocytes from Patients Undergoing Amadio, Kai-Nan An, Chunfeng Zhao Rotator CuffR epair Induce Adipose Derived Stem Cell Differentiation - Towards Tendon Engineering in the Poster No. 0476 Operating Room Improving Soft Tissue To Bone Healing: Intercellular Sandra J Siatkowski, Taylor Pate, Richard J Hawkins, Communication Between Tendon-Derived Cells And Michael Kissenberth, Stefan Tolan, Gregory P Colbath, Cells Involved In The Early Development Of Tendons Jeremy Mercuri Corina A Ghebes, Nathalie Groen, Hugo A M Fernandes, Daniel B F Saris Poster No. 0468 Comparison of Human Mesenchymal Stem Cells Derived from Various Spinal Tissues: Superiority of Facet Joint and Interspinous Ligament Baldur Kristjánsson, Worawat Limthongkul, Sittisak Honsawek

66 Poster No. 0477 Poster No. 0487 Cell-free Biodegradable Synthetic Artificial Ligament Differential Regulation of Growth and Differentiation for the Reconstruction of Anterior Cruciate Ligament Factor-5-induced Tenogenic and Osteogenic (ACL) in a Rat Model Differentiation In Tendon-derived Stem Cells Yohei Kawakami, Kazuhiro Nonaka, Koji Takayama, Yuan-Hung Chao, Jui-Sheng Sun, Yang-Hwei Tsuang Antonio D’Amore, Tomoyuki Matsumoto, Yutaka Mifune, James Cummins, Ryosuke Kuroda, Masahiro Kurosaka, PS1 Tendon/Ligament - Mechanics William R Wagner, Freddie H Fu, Johnny Huard Poster No. 0488 Poster No. 0478 Investigating Extensibility And Plastic Deformation siRNA-mediated Gene Silencing of PAI-1 Rescues In Isolated Type-I Collagen Fibrils Using Atomic Force Plasmin and MMP Activity in TGF-beta1 Treated Microscopy Flexor Tenocytes Andrew S Quigley, Laurent Kreplak, Samuel P Veres Margaret A Thomas, Youssef M Farhat, John C Elfar, Hani A. Awad Poster No. 0489 In situ Analysis of Anterior Cruciate Ligament Shape Poster No. 0479 and Morphology Tape Versus Suture - A Biomechanical Analysis In Eric Thorhauer, Yoshimasa Fujimaki, Ruben O’Hara-Plotnik, An Ovine Model And Post-operative Outcomes In Scott Tashman, Freddie H. Fu Arthroscopic Rotator Cuff Repair Patrick H Lam, RuiWen Liu, Henry Shepherd, Poster No. 0490 George AC Murrell Three-dimensional Anatomy And A Histological Study Of Equine Superficial Digital Flexor Tendon Poster No. 0480 Othman Ali, Peter Clegg, Eithne Comerford, Elizabeth In Vivo Evaluation of Heparin Mediated Growth Canty-Laird Factor Release from Tissue-Engineered Constructs for Anterior Cruciate Ligament Reconstruction Poster No. 0491 Natalie L Leong, Armin Arshi, Nima Kabir, Azadeh Nazemi, Evaluation of Work of Flexion in Flexor Tendon Graft Frank A Petrigliano, Benjamin Wu, David R McAllister with Different Junction Repair Techniques Jingheng Wu, Andrew Thoreson, Kai-Nan An, Peter C. Poster No. 0481 Amadio, Chunfeng Zhao Platelet-rich Plasma (PRP) Accelerates Murine Patellar Tendon Healing Through Enhancement Of Poster No. 0492 Angiogenesis And Collagen Synthesis The Biomechanical Role Of Fibre Twist Yohei Kobayashi, Yoshitomo Saita, Masashi Nagao, In The Achilles Tendon Hiroshi Ikeda, Kazuo Kaneko Vickie Shim, Justin Fernandez, Bruce Gardiner, David Smith, David Lloyd, Thor F Besier Poster No. 0482 Characterization of a Human MSC Population Poster No. 0493 Utilized to Fabricate Scaffold-less Ligament High-Load Preconditioning Protocols for Soft Tissue Constructs for ACL Repair Grafts Minimize Graft Elongation and Confer Stiffness Michael J Smietana, Pablo Moncada-Larrotiz, Equivalent to Native Anterior Cruciate Ligament under Ellen M Arruda, Lisa Larkin Simulated Early Rehabilitation Loading Jeffrey R. Jaglowski, Brady T. Williams, Travis L Turnbull, Poster No. 0483 Robert F LaPrade, Coen A Wijdicks Sticky Sutures: Improved Suture Repair Mechanics Through the Use of Adhesives Poster No. 0494 Stephen W Linderman, Ioannis Kormpakis, Richard Mechanical Properties of Semitendinosus H Gelberman, Victor Birman, Guy M Genin, Stavros Tendon Recover with Time Post Transection for Thomopoulos ACL Reconstruction

Stephen M Suydam, Daniel H Cortes, Thomas S Buchanan POSTERS Poster No. 0484 D ifferential Responses of Embryonic and Postnatal Poster No. 0495 Tendon Cells to Mechanical and Biochemical Wound Regional Mechanical Properties of the Long Head Healing Factors of the Biceps Tendon Kaori L Graybeal, Catherine K Kuo Christopher W Kolz, Thomas Suter, Heath B Henninger

Poster No. 0485 Poster No. 0496 WITHDRAWN The Effect of Fibrin Formulation on Initial Strength of Tendon Repair In Vitro Poster No. 0486 Kosuke Uehara, Chunfeng Zhao, Anne Gingery, Andrew T he Immunomodulatory Effect of Silver Nanoparticles Thoreson, Kai-Nan An, Peter C. Amadio is Critical for Promotion of Tendon Repair Karen Kwan, Kelvin Yeung, Kenneth Cheung, Michael To

67 Poster No. 0497 Poster No. 0507 Biomechanics And Micro-ct Scanning Of How Does BMP-7 Signal In Tenocytes? Normal Mouse Knee Ligaments Franka Klatte-Schulz, Gerry Giese, Karen Ruschke, Camila Carballo, Xiangyu Gu, Zoe Album, Scott Rodeo Jr, Regina Puts, Petra Knaus, Britt Wildemann Michael Mosca, Arielle Hall, Hongsheng Wang, Lilly Ying, Xiang-Hua Deng, Scott Rodeo Poster No. 0508 Differential Mechanical Regulation of Nuclear Poster No. 0498 Morphology in Wavy Structures Crimp Morphology In The Ovine ACL And How It Varies Chien An Chen, Pen-hsiu Grace Chao With Knee Position And In Relation To Its Double- bundle Structure Poster No. 0509 Lei Zhao, Neil Broom, Ashvin Thambyah Replicating In-vivo Behaviour Of Tenocytes Using A Cyclic Mechanical Strain Stimulator Poster No. 0499 Jungjoo Kim, Jillian Cornish, David Musson, Iain Anderson, Physical Activity and Bone Strength of Mice with an Vickie Shim Acute Ankle Lateral Ankle Sprain Nigel Zheng, Tracia Hubbart-Turner, Hollis Owens, Jeffery Poster No. 0510 Thousand, Erik Wikstrom, Mike Turner High CCN-1 Levels In Aging Tendons Promote Tendon Stem Cell Senescence And Tendon Degeneration PS1 Tendon/Ligament - Cell Biology Jianying Zhang, James Wang

Poster No. 0500 Poster No. 0511 Antioxidant’s Cytoprotective Effects on Rotator Characterization of Novel Tendon Phenotype in CuffT enofibroblasts Exposed to Aminoamide Local CCN1 Conditional Knockout Mice Anesthetics Jie Jiang, Jaime V Tan, Tien Phan, Nancy Morones, Ra Jeong Kim, Young-Sool Hah, Jae-Ran Kang, Karen M Lyons Hyung Bin Park Poster No. 0512 Poster No. 0501 Changes In The Inflammatory Cell Population Matrix-Specific Anchors: A Novel Concept for Targeted During Tendon Healing Delivery and Retention of Therapeutic Cells Parmis Sepanloo, Robert Blomgran, Jan Ernerudh, Mark L Wang, Pedro K Beredjiklian, Maulik D Shah, Per Aspenberg Ryan Hoffman, Andrzej Fertala Poster No. 0513 Poster No. 0502 Cell-Cell Junction Proteins and Embryonic Tendon Apoptotic Bodies from Tenocytes Enhance the Progenitor Cell Behavior are Influenced by Substrate Proliferation and Migration of Tenocytes and Bone Elastic Modulus and Protein Composition Marrow Mesenchymal Stem Cells In Vitro Canine Model Nathan Robert Schiele, Steven C Bench, Nicole A Danek, Chenhui Dong, Anne Gingery, Ramona Reisdorf, Kai-Nan Ava M Sanayei, Catherine K Kuo An, Peter C. Amadio, Chunfeng Zhao Poster No. 0514 Poster No. 0503 Il-1β Inhibits Tenogenic Differentiation And Lipid Raft and Caveolin Polarization Guide Fibroblast Accelerates Glycolysis Activity In Injured Tendon- Directional Migration in Electric Fields derived Progenitor Cells Shun-Hao Tsao, Bo-Jiang Lin, Pen-hsiu Grace Chao Kairui Zhang, Motomi Enomoto-Iwamoto POSTERS Poster No. 0504 Poster No. 0515 Prp On Inflammation Of Tenocytes Bone Marrow Derived Mesenchymal Stem Cells Seung Yeon Lee, Hyang Kim, Hyeyoun Kim, Ji Sun Shin, Transduced With SOX-9 Improve Rotator Cuff Healing Won Kee Park, Kang Sup Yoon, Chris Hyunchul Jo at an Early Time Point in a Rat Rotator Cuff Model Michael Schaer, Richard Ma, Will Gu, Marco Sisto, Ashley Poster No. 0505 Titan, Xiang-Hua Deng, Scott Rodeo P rp And Corticosteroid In Tenocyte Seung Yeon Lee, Hyang Kim, Hyeyoun Kim, Ji Sun Shin, Poster No. 0516 Won Kee Park, Kang Sup Yoon, Chris Hyunchul Jo MT3-MMP is Mediated by Elastic Modulus and Actin Cytoskeleton in Mouse Embryonic Tendon Progenitor Poster No. 0506 Cells In Vitro E ffect Of Hyperglycemia On Degeneration And Steven C Bench, Nathan R Schiele, Catherine K Kuo Inflammation Of Rat Tenocytes Yasuhiro Ueda, Atsuyuki Inui, Takeshi Kokubu, Yutaka Poster No. 0517 Mifune, Tomoyuki Muto, Yoshifumi Harada, Fumiaki Takase, Differential Effects of Growth Factors on Neonatal and Masahiro Kurosaka Adult Achilles Tenocytes Julianne Huegel, Robert Mauck, Louis Soslowsky, Andrew F Kuntz

68 PS1 Muscle - Mechanics Poster No. 0528 Fatty Infiltration Of Rotator Cuff Muscles fterA Poster No. 0518 Tenotomy Is Associated With Desensitation Of Measuring Hydraulic Permeability of Skeletal Muscles Androgen Receptor Signalling Lijian Peng, Michael Schenk, Xingyu Chen, Brandon K Martin Flück, Severin Ruoss, Céline Ferrié, Christoph Möhl, Zimmerman, Xin Lu, Liyun Wang Hans Hoppeler, Mario Benn, Brigitte von Rechenberg, Mazda T Farshad, Karl Wieser, Dominik C Meyer, Poster No. 0519 Christian Gerber changes in Muscle Thickness During Contraction on Return to Sports After a Hamstring Muscle Poster No. 0529 Strain Injury Muscle Atrophy in Osteosarcoma-Induced Yasuharu Nagano, Ayako Higashihara, Mutsuaki Edama Cancer Cachexia Xiaodong Mu, Adam Rothenberg, Clifford Voigt, PS1 Muscle - Biology Johnny Huard, Kurt Weiss

Poster No. 0520 Poster No. 0530 Sclerostin Deficient MiceD isplay Sarcopenia But Also Collagen,Proteoglycan and SLRP Contribute to Resistance To Bone Loss During Hind Limb Suspension Stiffness in Human Skeletal Muscle Contractures Andrew R Krause, Henry Donahue, Charles Lang, Jennifer Rajeswari Pichika, Rachel Meza, Lucas Smith, Steiner, Toni Speacht, Yue Zhang, Peter M Govey Samuel R Ward, Richard L Lieber

Poster No. 0521 Poster No. 0531 Prenatal and Pre-weaning Exposure to Low-dose T he Role of Muscle Satellite Cells in Contracture of Benzo(a)pyrene, a Cigarette Smoke-Associated Pathophysiology following Neonatal Brachial Hydrocarbon, Impairs Skeletal Muscle Development in Plexus Injury F1 Generation Mice Athanasia Nikolaou, Liangjun Hu, Roger Cornwall Rong S Yang, Chen Y Chiu, Shing H Liu Poster No. 0532 Poster No. 0522 Volumetric Muscle Loss: Persistent Functional Losartan Improve The Muscle Regeneration Deficits Beyond Frank Loss Of Tissue Potential Of Muscle Derived Stem Cell Koyal Garg, Catherine L Ward, Brady Hurtgen, Jason Makoto Kobayashi, Yohei Kawakami, Satoshi Tateda, Wilken, Daniel J. Stinner, Joseph Wenke, Johnny G. Owens, Shusuke Ota, Takanobu Otsuka, Freddie H Fu, Benjamin T Corona Johnny Huard Poster No. 0533 Poster No. 0523 T ype 2 Diabetes Associated Beta-Adrenergic Receptor Concomitant Musculoskeletal Injury Results in Polymorphisms Are Independently Associated with Delayed Fracture Healing and Heightened and BMI and Physical Activity in College-Age Populations Prolonged Immune Response Zachary Kendrick, Courtney A Sprouse, Heather Gordish- Brady J. Hurtgen, Koyal Garg, Catherine L Ward, Joseph C. Dressman, Michael Liu, Elizabeth Hedges, Elizabeth Wenke, Benjamin T Corona Dominic, Jackie McKesey, Dustin Hittel, Gina M Many, Whitney L Barfield, Eric Hoffman, Laura L. Tosi, Joseph M. Poster No. 0524 Devaney H uman Myogenic Reserve Cells: A Source of Quiescent Muscle Stem Cell That Improves Muscle Regeneration Poster No. 0534 Thomas Laumonier, Flavien Bermont, Pierre Hoffmeyer, P rogranulin Deficiency And Chronic Systemic Jacques Menetrey Inflammation In Muscular Dystrophic Mice Xiaodong Mu, Ying Tang, Bing Wang, Kurt Weiss, Poster No. 0525 Johnny Huard ErbB’s Palsy? A Molecular Link between Afferent

Innervation, Muscle Spindles, and Contractures Poster No. 0535 POSTERS following Neonatal Brachial Plexus Injury S tructural and Biological Response of Peripheral Athanasia Nikolaou, Liangjun Hu, Roger Cornwall Nerves to Tensile Mechanical Loading Sameer B. Shah, Kenneth M Vaz, Ian Foran, Poster No. 0526 James M Love, Ting-Hsien Chuang VEGF Gene Transfer Enhances Human Myogenic Precursor Cell Survival After Transplantation in Poster No. 0536 Injured Skeletal Muscles C ol5a1 Variant Is Associated With Body Composition Thomas Laumonier, Flavien Bermont, Pierre Hoffmeyer, And Physical Activity In Males Jacques Menetrey Elizabeth Dominic, Courtney A Sprouse, Heather Gordish- Dressman, Zachary Kendrick, Michael Liu, Elizabeth Poster No. 0527 Hedges, Jacqueline McKesey, Eric Hoffman, Laura L Tosi, The Effect of Microgravity on Mouse Shoulder Muscle Joseph M. Devaney mRNA and Protein Expression Hua Shen, Chanteak Lim, Andrea G Schwartz, Stavros Thomopoulos 69 PS1B Bone/ one Biology - Skeletal Development Poster No. 0547 Design and Proof of Concept for a Single Cell Poster No. 0537 Electromagnetic Loading Device Development and Validation of a 3D Printed Chemical Emily Noonan, Sarah Ferrell, Phillip Leopold, Screening System for Osteoactive Compound Antonio Valdevit Discovery in the Regenerating ZebrafishT ail Fin Adrian T Monstad-Rios, Ronald Y Kwon Poster No. 0548 Assessment of the Effect of Systemic Delivery of Poster No. 0538 Sclerostin Antibodies on WNT Signaling in Distraction Prediction Of The Role Of Stenotic Sutures In The Osteogenesis Using Immunohistochemistry Pathological Growth Of Newborns Skulls Mohammad M Alzahrani, Asim M Makhdom, Dominique Florian Jalbert, Jérôme Briot, Frédéric Lauwers, Lauzier, Maria Kotsiopriftis, Reggie C Hamdy Pascal Swider Poster No. 0549 Poster No. 0539 Long Bones of Growing Thrombospondin-2 Null Mice Pinpointing the Earliest Manifestations of Skeletal Display Altered Collagen Fibril Morphology and a Disease in Mucopolysaccharidosis Disorders Brittle Phenotype Sun H Peck, Philip J.M. O’Donnell, Joseph A Chiaro, Eileen Andrea I Alford, Joseph E Perosky, Kenneth M Kozloff, M Shore, Maurizio Pacifici, Mark E Haskins, Neil R. Malhotra, Basma Khoury Lachlan J Smith Poster No. 0550 Poster No. 0540 The Carboxy Terminus of Secreted Phosphoprotein 24 M ethylphenidate Impairs Skeletal Development kD (spp24) Contains a Second BMP/TGF-β Binding Site In Adolescent Female Rats and Can Independently AffectB MP-2 Activity Evan Chernoff, Lisa S Robinson, Michalis P Michaelos, Haijun Tian, Chen-Shuang Li, Ke-Wei Zhao, Jeffrey C Wang, Jason Gandhi, Panayotis K Thanos, Michael Hadjiargyrou, M. Eugenia L Duarte, Cynthia L David, Kevin Phan, Elisa David E Komatsu Atti, Elsa J Brochmann, Samuel S Murray

Poster No. 0541 PS1 Bone/Bone Biology - Osteoblasts Markers Of Bone Health In Pediatric Patients With Fractures Compared With Healthy Controls Poster No. 0551 Ashley Olson, Sara Merwin, Selina Poon, Jahn Avarello A Mechanism to Explain the Bone Loss in Metal-on- Metal Cobalt-containing Implants Poster No. 0542 Edward Puzas, Edward M. Schwarz, Tzong-Jen Sheu Greater Heritability in Bone Structural versus Bone Matrix Properties Poster No. 0552 Ryan D Ross, Meghan M Moran, Maleeha Mashiatulla, The Regulation of Bone Formation by the Lisa Miller, D. Rick Sumner Met-5-enkephalin-Opioid Growth Factor Receptor Signaling Axis PS1 Bone/Bone Biology - Bone Aging N ikhil Thakur, Sean D DeBoyace, Bryan S Margulies

Poster No. 0543 Poster No. 0553 Age-Dependent Recovery of Bone During Reloading The Regulation of Bone Formation and Bone Following a Period of Hindlimb Unloading in Rats Re-absorption by the Repulsive Guidance Molecules Hailey C Cunningham, Daniel WD West, Leslie M Baehr, S ean D DeBoyace, Adrienne M Parsons, Jessica SS Ee, Keith Baar, Sue C Bodine, Blaine A Christiansen Bryan S Margulies POSTERS

Poster No. 0544 Poster No. 0554 Calcium- and Phosphorus-Supplemented Diet and Evaluation of Bioburden on the Development of Exercise Prevent Loss of Cortical and Trabecular Bone Heterotopic Ossification in anE stablished Rat Model with Aging in Mice Gabriel J Pavey, Donald N. Hope, Dana M. Golden, Ammar Michael A Friedman, Robert Szczepankiewicz, David Kohn T. Qureshi, Benjamin K Potter, Rebecca L. Pavlicek, Thomas A. Davis, Jonathan A. Forsberg Poster No. 0545 Muscle And Bone Regeneration Upon Poster No. 0555 Castration And Treadmill Exercise Evaluation of the Effect of Vancomycin Powder on Ioannis Stratos, Konrad Schröpfer, Katharina Hink, Philipp Bone Healing in a Rat Spinal Arthrodesis Model Herlyn, Mario Bäumler, Tina Histing, Michael D. Menger, Marco C Mendoza, Kevin Sonn, Sharath S Bellary, Abhishek Sven Bruhn, Thomas Mittlmeier, Brigitte Vollmar Kannan, Gurmit Singh, Christian Park, Stuart R Stock, Erin L Hsu, Wellington Hsu PS1 Bone/Bone Biology - Matrix Proteins

Poster No. 0546 Cd44 Signaling Mediates Osteoactivin/gpnmb Effects On Bone Homeostasis Gregory R Sondag, Thomas Mbimba, Fouad Moussa, 70 Kimberly Novak, Bing Yu, Fayez Safadi PS1B Bone/ one Biology - Osteoclasts Poster No. 0566 Microgravity during 30 Days Space Flight Induced Poster No. 0556 Bone Morphological Changes and Bone Mineral Tmem178 Is A Negative Regulator Of Bone Density Decrease in the Mouse Lumbar Spine Homeostasis And Osteoclast Activation In Mice Kevin Cheng, Brandon R Macias, Alan R Hargens, Esther And Humans Via A Novel Negative Feedback Loop Cory, Keianne D Yamada, Jeffrey Lotz, Robert L Sah, Targeting Endoplasmic Reticulum Ca2+ Mobilization Koichi Masuda Corinne Decker, Roberta Faccio Poster No. 0567 Poster No. 0557 Osteopenia Uncovered By Micro-mechanical Osteoclasts Are Significantly Affected By The Moduli In The Cortical Mid-diaphysis Concentration Of Advanced Glycation End Kartikey Grover, Minyi Hu, Liangjun Lin, Jesse Muir, Products (AGEs) In Medium Released From Yi-Xian Qin Bone Resorption Process Xiao Yang, Evan Veregge, Mark R Appleford, Xiaodu Wang Poster No. 0568 Loading Induced Mechanobiological Modulation Poster No. 0558 of In Situ Osteocytic Ca2+ Oscillations in an Intact Metabolic Regulation of Osteoclast Differentiation Mouse Femur by Hif1κ in Human Osteoclastgenesis Minyi Hu, Guowei Tian, Yi-Xian Qin Koichi Murata, Kyung-Hyun Park-Min, Lionel B Ivashkiv Poster No. 0569 Poster No. 0559 Osteocyte Ca2+ Signaling In Response To Effect Of Repeated Oral Administration Of A Mechanical Loading In Vivo Cathepsin k Inhibitor On Bone Turnover And Bone K arl J Lewis, Dorra Benayed, David Spray, Mia Thi, Robert J. Quality In Healthy Adult Exercising Horses Majeska, Sheldon Weinbaum, Mitchell B. Schaffler Hayam Hussein, Jennifer Dulin, Lauren Smanik, Alicia L Bertone Poster No. 0570 Estrogen Loss Causes Mitochondrial Electron Poster No. 0560 Transport Chain Dysfunction in Osteocytes in vivo SubAB Prevent Joint Inflammation And Destruction D orra Frikha-Benayed, Jelena Basta-Pljakic, Robert J. Via Er Stress In Collagen Induced Arthritis Majeska, Mitchell Schaffler Kensuke Koyama, Tetsuro Ohba, Atsuhito Nakao, Hirotaka Haro Poster No. 0571 Assessment of MMP-2, MMP-3, And Osteocyte Poster No. 0561 Apoptosis in The Lacunar-canalicular Network of Siglec15 Mediates Periarticular Bone Loss But Not Estrogen-deficientR ats Joint Destruction In Murine Antigen induced Arthritis Divya Sharma, Andrew Moon, Damien M Laudier, Stephen Tomohiro Shimizu, Masahiko Takahata, Yusuke Kameda, B Doty, Mitchell B Schaffler, Susannah P Fritton Hiroki Hamano, Norimasa Iwasaki Poster No. 0572 PS1 Bone/Bone Biology - Bone Osteocytes and Femoral Cortical Bone Quality And Osteocyte Network Mechanobiology Characteristics In Young, Aged, Osteoporotic And Alendronate-treated Individuals Poster No. 0562 Petar Milovanovic, Elizabeth Zimmermann, Christoph Development Of A Computational Model To Study Riedel, Annika vom Scheidt, Matthias Krause, Danijela Tissue Evolution In 3D Biodegradable Scaffolds Djonic, Michael Hahn, Maria Djuric, Michael Amling, Chaochao Zhou, Ryan Willing Robert Ritchie, Klaus Pueschel, Björn Busse

Poster No. 0563 Poster No. 0573 Osteocyte-Mediated Remodeling of the Perilacunar Exposure to Cobalt and Chromium Ions Reduces

Bone Matrix is Repressed by Glucocorticoids Osteocyte Response to Mechanical Loading POSTERS Faith Hall-Glenn, Aaron J. Fields, Hrishikesh Bale, Ian Eigl, Peter Orton, Karan M Shah, J. Mark Wilkinson, Alison Robert Ritchie, Thomas Vail, Jeffrey Lotz, Tamara Alliston Gartland

Poster No. 0564 PS1 Bone/Bone Biology - Progenitors and Stem Cells Osteocytes’ Response to Mechanical Loading Supports Breast and Prostate Cancer Cell Growth and Migration Poster No. 0574 Yu-Heng Ma, Shreyash Dalmia, Peter Gao, Chao Liu, Do Mesenchymal Stromal Cells Abrogate The Host Lidan You Immune Response In Massive Cortical Allograft Recipients? Poster No. 0565 Kaitlyn McNamara, John Coy, Amanda Guth, Steve Dow, Dramatic Effects Of High And Low Glucose Nicole Ehrhart On Osteocytes: A Model For The Effects Of Glucose On Bone Loss Donna Pacicca, Tammy Brown, Karen Kover, Lynda F Bonewald 71 Poster No. 0575 PS1 Bone/Bone Biology - Osteoporosis, Metabolic Bone NF-κB Decoy Oligodeoxynucleotide Enhanced Disease, Biomarkers Osteogenesis in Mesenchymal Stem Cells Exposed to Polyethylene Particle Poster No. 0584 Tzu-Hua Lin, Taishi Sato, Florence Loi, Ruth Zhang, Jukka Does Long-term Bisphosphonate Therapy Pajarinen, Zhenyu Yao, Stuart B Goodman Cause Brittle Fractures? Andi Jin, Jianmo Li, Ulrich Hansen, Rajarshi Bhattacharya, Poster No. 0576 Justin Cobb, Richard Abel Human Mesenchymal Stem Cell (hMSC) Spheroids Promote Large Bone Defect Repair Poster No. 0585 Ashley B Allen, Joshua A Zimmermann, Laura D Cox, Hazel Novel Assessment Of Bone Using Raman Spectroscopy Y Stevens, Todd C McDevitt, Robert E Guldberg To Detect Changes Associated With Osteogenesis Imperfecta In Mice Bones Poster No. 0577 Benan M Dala-Ali, Jemma Kerns, Panos Gikas, Kevin Reduced Anabolic Response To Parathyroid Hormone Buckley, Anthony W Parker, Pavel Matousek, Pascale In Periosteal Mesenchymal Stem Cells From Aged Mice Guillot, Allen E Goodship Li Yue, Alayna Loiselle, Jennifer Jonason, Regis O’Keefe Poster No. 0586 Poster No. 0578 Comparison Of Rankl Blockade And Bisphosphonate Differential Signaling Through BMP Type 1 Receptors Therapies In A Growing Mouse Model Of OI - ALK2 and ALK3 in the Formation of Trauma-Induced Implications Of Prolonged Treatment On Bone Health Heterotopic Ossification J Marino, N Pleshko, E Carter, K Jepsen, S Doty, A Boskey, C Jonathan R Peterson, Oluwatobi N Eboda, Agustin H Raggio Mohedas, Shawn Loder, Robert C Brownley, Shailesh Agarwal, Kavitha Ranganathan, Steven R Buchman, Poster No. 0587 Paul S Cederna, Yuji Mishina, Stewart C Wang, Paul B Yu, Sclerostin Antibody Dose-dependently Increases Benjamin Levi Bone Mass And Strength In Brtl/+ Oi Mice David K. Barton, Benjamin P. Sinder, Michael S. Ominsky, Poster No. 0579 Terese Jenks, Joan C. Marini, Michelle S. Caird, Pericytes Support Bone Regeneration by Kenneth M Kozloff Complementary Mechanisms - an in vitro Investigation into the Angiogenic and Osteogenic Properties of Poster No. 0588 Pericytes Derived from Multiple Tissue Sources Brittleness in Osteoblast-derived BMP2 Knockout Marietta Herrmann, Jennifer J Bara, Ursula Menzel, Jagoda Bones is Due to Increased Porosity Cellularity M Jalowiec, Rik Osinga, Arnaud Scherberich, Mauro Alini, Zachary Toth, Sarah Howe McBride Sophie Verrier Poster No. 0589 Poster No. 0580 Increased Concentration Of Indian Hedgehog (ihh) In Ips Cells Can Be Efficiently Differentiated Back Synovial Fluid (sf) Is Associated With Joint Injury And To Mscs Using A Short Exposure To Tgfβ Early Cartilage Degradation In Human Knee Joint Dmitriy Sheyn, Shiran Ben-David, Sandra Ann De Mel, Congming Zhang, Yunming Zhang, Renqi Jiang, Jun Wang, Loren Ornelas, Anais Sahabian, Dhruv Sareen, Xiaoyu Da, Qi Pei, Qian Chen, Lei Wei Wafa Tawackoli, Dan Gazit, Zulma Gazit Poster No. 0590 Poster No. 0581 Type 1 Diabetes Impairs Long Bone SIRT1-SOX2 Axis Is Important for Maintaining Response to Exercise in Mice POSTERS Self-renewal and Multipotency in Bone Marrow- Zeynep Seref-Ferlengez, Hui Bin Sun, derived Mesenchymal Stem Cells Mitchell B. Schaffler, Sylvia O Suadicani, Mia M Thi Dong Suk Yoon, Yoorim Choi, Yeonsue Jang, Woo Jin Choi, Sung-Hwan Kim, Jaewan Suh, Moses Lee, Jin Woo Lee Poster No. 0591 Sheep Model Reflecting Glucocorticoid-induced Poster No. 0582 Osteoporosis In Postmenopausal Women B acterial Toxin-activated Leukocytes As A Christina M Andreasen, Ming Ding, Soeren Overgaard, Model For Inflammation-induced Differentiation Peter Bollen, Thomas Levin Andersen Of Mesenchymal Stem Cells Manfred Koeller, Christina Sengstock, Dominik Sybold, Poster No. 0592 Jan Gessmann, Thomas A Schildhauer Inhibiting Mirna-100 Is Associated With Increased Osteogenesis In Osteoblasts From Poster No. 0583 Osteoporotic Patients L-WNT3a Enhances Bone Regeneration Sarah Kelch, Claudine Seeliger, Marina Unger, In A Murine Model Of Osteonecrosis Martijn van Griensven Jingtao Li, Chelsey A Johnson, Benjamin Salmon, Marie Ezran, Jill A Helms Poster No. 0593 The Axial Dependence of Bone Density and Ultrasound at the Radius Jonathan J. Kaufman, Grant Nagaki, Gangming Luo, Alfred 72 Rosenbaum, Robert S. Siffert Poster No. 0594 Poster No. 0603 Age-related Changes in the Microstructural In Vivo Mechanical Loading in Murine Tibiae as a Organization of the Femoral Neck Suggest Function of Applied Strain Results in Differential Degradation in Bone Quality Independent of Changes in Microstructure and Fatigue Response Cortical Thinning and Increased Porosity Creasy A Clauser, Alycia Berman, Caitlin Wunderlin, Kendra E Keenan, Chad S Mears, Tanner D Langston, Joseph M Wallace Colton M Phippen, Scott M Litton, S. Taylor Brady, Roy D Bloebaum, John G Skedros Poster No. 0604 Improvements in Bone’s Biomechanical Poster No. 0595 Properties with Short-Term Whole Body Vibration Susceptibility to Obesity and Bone Mineral Density are Independent of Amplitude and Confined ot in Young African American Populations Cancellous Bone Michael Liu, Courtney A Sprouse, Heather Gordish- William Runge, Laurence Dahners, Denis Marcellin-Little, Dressman, Elizabeth Hedges, Zachary Kendrick, Elizabeth Ola Harrysson, David Ruppert, Paul Weinhold Dominic, Jacqueline McKesey, Leticia Ryan, David Rowlands, Kevin Bell, Joseph M. Devaney, Laura L Tosi Poster No. 0605 Removing or Truncating Connexin 43 in Osteocytes PS1 Bone/Bone Biology - Bone Mechanics and Finite Alters Nanoscale Composition and Microscale Element Analysis Mechanics Max A Hammond, Rafael Pacheco-Costa, Hannah M Davis, Poster No. 0596 Lilian I. Plotkin, Joseph M. Wallace A Novel Anterior Transpedicular Screw Artificial Vertebral Body System For Lower Cervical Spine Poster No. 0606 Fixation: A Finite Element Study Initiation and Propagation of Microdamage in Jun Ouyang, Weidong Wu Cancellous Bone Occurs Preferentially Distant from Resorption Cavities Poster No. 0597 Jonathan B Matheny, Ashley M Torres, Matthew G Goff, A Validated FE Model for Proximal Tibia Bone Grafting: Clare M Rimnac, Christopher J Hernandez The Study of the Effect of Window Size on Tibia Stability and Mechanics Poster No. 0607 David QK Ng, Chin Tat Lim, Wilson Wang, Ken Jin Tan, Intermittent PTH after Prolonged Bisphosphonate Desmond YR Chong Treatment Improves Bone Structure by Inducing Substantial New Bone Formation with Decoupled, Poster No. 0598 Inhibited Bone Resorption in Ovariectomized Rats A Cadaveric Study of Bone Tissue Temperature During Allison R Altman, Carina Lott, Chantal M de Bakker, Wei-Ju Pin Site Drilling Utilizing Fluoroptic Thermography Tseng, Ling Qin, X. Sherry Liu Matthew T Muffly, Corbett Winegar, Gregory T Altman PS1 Bone/Bone Biology - Bone Tissue Engineering and Poster No. 0599 Repair Biomechanical Comparison of the Human Cadaveric Pelvis with a 4th Generation Composite Model Poster No. 0608 Brandon L. Girardi, Tarik Attia, David Backstein, Oleg Safir, P ro-inflammatoryT Cells Stimulate Osteoblast Thomas L. Willett, Paul R. T. Kuzyk Maturation In Vitro Michiel Croes, Cumhur F Öner, Moyo C Kruyt, Wouter JA Poster No. 0600 Dhert, Jacqueline Alblas Stress Analysis At The Boundary Of The Necrotic Lesion Kazuyuki Karasuyama, Takuaki Yamamoto, Goro Poster No. 0609 Motomura, Ryosuke Yamaguchi, Kazuhiko Sonoda, Yusuke P orous Growth Plate Extracellular Matrix-derived Kubo, Yukihide Iwamoto Scaffolds Facilitate Osteogenesis of MSCs In Vitro and Accelerate Host-mediated Bone Healing In Vivo

Poster No. 0601 Grainne M Cunniffe, Pedro J Diaz-Payno, Emmet POSTERS Assessment Of Lumbar Vertebral Strength In Bone Thompson, Fergal J O’Brien, Daniel J Kelly Metastasis Patients With Vertebral Lesions Before And After Anti-RANKL Antibody Administration; Poster No. 0610 Pilot Study D evelopment of a Novel Self-Organizing, Cell-Based Katsuhisa Kawanami Bone Graft Substitute: Control of Bone Dimension and Structure Poster No. 0602 Yijia Hong, Pooja Desai, Bernard Halloran, Alan B.C. Dang Effects Of Fixation And Demineralization On Bone Collagen D-spacing As Analyzed By Atomic Force Poster No. 0611 Microscopy W nt5a-BMP2 Crosstalk Regulates Spontaneous Joseph Michael Wallace Stem Cell-Osteoblastic Differentiation on Micro- Nanostructured Titanium Rene Olivares-Navarrete, David Haithcock, Christy Wasilewski, Caitlin A Cundiff, Sharon L Hyzy, Zvi Schwartz, Barbara D. Boyan 73 Poster No. 0612 Poster No. 0621 microRNA-activated Scaffolds for Enhancing Enhanced Formation of Mechanically Functional Bone Formation by Mesenchymal Stem Cells Engineered Bone by Hypertrophic Chondrocytes through the Regulation of Osteogenic Genes Jonathan C Bernhard, Sarindr Bhumiratana, Ming Li, Irene Mencía Castaño, Caroline M Curtin, Georgina Shaw, Gordana Vunjak-Novakovic Mary J Murphy, Garry P Duffy, Fergal J O’Brien Poster No. 0622 Poster No. 0613 Heritable Differential Bone Regeneration is Present An Immediate Source Of Purified utologousA As Early As Seven Days after Marrow Ablation in the Mesenchymal Stem Cells For Musculoskeletal Mouse Model Regeneration Meghan M Moran, Amarjit Virdi, Steven Mazzone, D. Rick Iain R Murray, Christopher West, Winters Hardy, Mirko Sumner Corselli, Hamish Simpson, Xinli Zhang, Chia Soo, Bruno Peault PS1 Bone/Bone Biology - Computational Modeling

Poster No. 0614 Poster No. 0623 Comparative Analysis of Rat Mesenchymal Stem Cells A Semi-automated Method For Defining Cortical Derived from Slow and Fast Skeletal Muscle in Vitro Bone Breaks In Cadaveric Finger Joints Using High- Sang Yang Lee, Etsuko Okumachi, Takahiro Niikura, resolution Peripheral Quantitative Ct And Microct Takashi Iwakura, Yoshihiro Dogaki, Shunsuke Takahara, Michiel Peters, Andrea Scharmga, Chris Arts, Astrid van Takeshi Ueha, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Tubergen, Jeroen Williams, Joop Van den bergh, Bert Kurosaka Rietbergen, Piet Geusens

Poster No. 0615 Poster No. 0624 Positive Effect Of Platelet-derived Growth Factor Experimental And Computational Micro-mechanics At Bb On Adipose-derived But Not Marrow-derived The Tibial Cement-bone Interface Mesenchymal Stem Cells Priyanka Srinivasan, Mark A Miller, Nico Verdonschot, Ben P Hung, Daphne L Hutton, Kristen L Kozielski, Corey Kenneth A. Mann, Dennis Janssen J Bishop, BIlal Naved, Jordan J Green, Arnold I Caplan, Jeffrey M Gimble, Amir H Dorafshar, Warren L Grayson Poster No. 0625 Loading Induced 2nd Messenger and Transcriptional Poster No. 0616 Interactions Mediate Multiple Measures of Bone The Healing Of Tibial And Calvarial Defect Using Adaptation Runx2-transfected Adipose Stem Cells Sundar Srinivasan, Edith Gardiner, Brandon J Ausk, Ronald Jong-Min Lee, Eun-Ah Kim, Gun-Il Im Y Kwon, Ted Gross

Poster No. 0617 Poster No. 0626 A Predictive Model for Understanding Stem Cell Predicting Wrist Biomechanics During Scapholunate Response on Allograft Bone through DLX5, RUNX2 and Ligament Dissociation Using a 3D Computational SP7 Production Model Mary E Blackmore, Cody W Saylor, Shawn A Hunter Edward J Tremols, Jennifer S Wayne

Poster No. 0618 Poster No. 0627 Mapping in situ Tissue Genesis by Stem Cells and R at Cortical and Trabecular Bone: Hierarchical Analysis Potential Implications of Intrinsic Implant Mechanical and Multi-Scale Modeling Stress Ramin Oftadeh, Vahid Entezari, Guy Spörri, Juan C Villa, POSTERS Celine Heu, Ulf Knothe, Stefan Milz, Melissa Knothe Tate Henry Krigbaum, Elsa Strawich, Lila Graham, Christian Rey, Hank Chiu, Ralph Müller, Hamid Nayeb Hashemi, Ashkan Poster No. 0619 Vaziri, Ara Nazarian Platelet Rich Plasma Gel As An Autologous Delivery System Of Growth Factors And Cells PS1 Bone Fracture - Biology Jagoda M Jalowiec, Marietta Herrmann, Ursula Menzel, Matteo D’Este, Jennifer J Bara, Mauro Alini, Sophie Verrier Poster No. 0628 Cannabidiol, a Major Non-Psychotrophic Cannabis Poster No. 0620 Constituent Enhances Fracture Healing and Stimulates Fibromodulin Reprogrammed Cells for Bone Lysil Hydroxylase Activity in Osteoblasts Regeneration Eitan Melamed, Natalya M Kogan, Yankel Gabet, Elad Zhong Zheng, Pu Yang, Chen-Shuang Li, Elizabeth L Lord, Wasserma, Batya Raphael, Aviva Breuer, Kathryn S Stok, Kambiz Khalilinejad, Juyong Park, Caroline Chung, Tara Ana Veronica Villarreal Escudero, Rachel Sondergaard, Aghaloo, Xinli Zhang, Kang Ting, Chia Soo Malka Attar-Namdar, Silvina Friedlander-Barenboim, Raphael Mechoulam, Ralph A Müller, Alon Bajayo, Itai Bab

74 Poster No. 0629 Poster No. 0637 (-)-epigallocatechin-3-gallate (egcg) Enhances Bone Loss of Anterior Stability of Shoulder Across Defect Healing a Range of Motion Due to Combined Bony Defects: Chung-Hwan Chen, Yi-Shan Lin, Yin-Chih Fu, Mei-Ling Ho, A Cadaveric Study Je-Ken Chang, Chih-Kuang Wang, Lin Kang Piyush Walia, Lionel Gottschalk, Ronak Patel, Matthew Kuklis, Morgan Jones, Stephen Fening, Anthony Miniaci Poster No. 0630 Systemically Administered Micelles Containing Poster No. 0638 Simvastatin Improve Fracture Healing in Aged Mice The Effects of Latarjet Reconstruction on Alexia Hernandez-Soria, Yen Hsun Chen, Adam L. Johnson, Glenohumeral Instability in the Presence Yijia Zhang, Dong Wang, Marjolein C.H. van der Meulen, of Combined Bony Defects Mathias P.G. Bostrom, Chitra L. Dahia, Ed Purdue, Steven Piyush Walia, Ronak Patel, Lionel Gottschalk, Matthew Goldring, Aaron Daluiski Kuklis, Morgan Jones, Stephen Fening, Anthony Miniaci

Poster No. 0631 Poster No. 0639 Age-related Emergence of Deleterious Buckling Ratio Trends in the Burden of Hip Fractures - in the Femoral Neck Fails to Maintain the Coupling What Does the Past Tell Us? with Predominant Collagen Fiber Orientation and Kevin L Ong, Edmund Lau, Steven Kurtz Osteon Morphotypes Seen in Younger Bones Chad S Mears, Kendra E Keenan, Tanner D Langston, Poster No. 0640 Colton M Phippen, Scott M Litton, S. Taylor Brady, Roy D Effects Of Preoperative Nutritional Status On 30-day Bloebaum, John G Skedros Mortality In Elderly Patients Undergoing Operative Management Of Hip Fractures Poster No. 0632 Adam Graver, Bin Yang, Sara Merwin, Michael O’Connor, Heterogeneity and Fragility Fracture Risk: Ariel Goldman An FTIRI Study Adele L Boskey, Eve L. Donnelly, Zhen Xiang Wang, Poster No. 0641 Lyudmilla Spevak, Yan Ma, Wei Zhang, Robert Recker Biomechanics of Acute Total Hip Arthroplasty after Acetabular Fracture: Plate vs Cable Fixation Poster No. 0633 Mina Aziz, Omar Dessouki, Saeid Samiezadeh, Habiba Association Of Serum Vitamin D Levels With Risks For Bougherara, Radovan Zdero, Emil H Schemitsch Surgical Pediatric Fracture Barbara Minkowitz, Tim U. Leier, Joseph T Nguyen, Eileen Poster No. 0642 Poletick, Nicole D Formoso, Barbara Cerame, Sherri L T he Utility of Taper-wedged Stem for Bipolar Luxenberg, Joseph M Lane Hemiarthroplasty in Patients with Displaced Femoral- neck Fractures: A Morphological and Clinical Study Poster No. 0634 Satoshi Ikemura, Taro Mawatari, Takahiro Iguchi, Gen Cartilage To Bone Transformation Through Matsui, Hiroaki Mitsuyasu Reactivation Of Pluripotent Stem Cell Programs: A New Paradigm In Endochondral Fracture Repair Poster No. 0643 Diane P Hu, Federico Ferro, Aaron J Taylor, Frank Yang, The Novel Method Of External Fixation Theodore Miclau, Wenhan Chang, Ralph S Marcucio, In Unstable Pelvic Ring Fracture Chelsea S Bahney Keisuke Oe, Kouki Nagamune, Takahiro Niikura, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 0634A Sost Antibody Treatment Improves Fracture Poster No. 0644 Healing in Type 1 Diabetes Experimental Investigations On Three Fixation Cristal Yee, Liqin Xie, Sarah Hatsell, Deepa Murugesh, Aris Methods (CSs, DHS+DS, And PFLP) Of Femoral N Economides, Gabriela Loots, Nicole Collette Neck Fractures In Young Adults Shabnam Samsami, Sadegh Saberi, Nima Bagheri, Nazanin

PS1 Bone Fracture - Biomechanics/Clinical Daneshvar H, Mohammad J Ein-Afshar, Golamreza Rouhi POSTERS

Poster No. 0635 Poster No. 0645 Mini Fragment Fixation of Clavicle Fractures: A Biomechanical Comparison Of Four Methods Of A Biomechanical Study Treatment For Periprosthetic Distal Femur Fractures Ali Alhandi, Jason Lowe, Edward Milne, David Kaimrajh, Tatu J Makinen, Gil Fichman, Herman Dhotar, Matthew Jason Albert, Loren Latta Gunton, Mitchell Woodside, Oleg Safir, David Backstein, Thomas L Willett, Paul R Kuzyk Poster No. 0636 Stability of the Glenohumeral Joint with Combined Poster No. 0646 Humeral Head and Glenoid Defects: A Cadaveric Study Axial and Rotational Mal-Reduction (Golf Club Lionel J Gottschalk, Piyush Walia, Ronak Patel, Matthew Deformity) in Distal Femur Fractures Kuklis, Morgan Jones, Stephen D Fening, Anthony Miniaci Ali Alhandi, Willard Moore, Jason Lowe, Edward Milne, David Kaimrajh, Loren Latta

75 PS1 Bone Fracture - Repair/Therapeutics Poster No. 0656 C annulated Lag Screw Fixation of Displaced Poster No. 0647 Lateral Humeral Condyle Fractures is Associated Local Application of a Proteasome Inhibitor with Lower Rates of Open Reduction and Infection Enhances Fracture Healing in Rats than Pin Fixation Toshitaka Yoshii, Jeffry S Nyman, Gloria Gutierrez Benjamin E Stein, Alim F Ramji, Hamid Hassanzadeh, Jared M Wohlgemut, Michael C Ain, Paul D Sponseller Poster No. 0648 The Effects of the Duration of Transcutaneous Poster No. 0657

CO2 Application on the Facilitatory Effect Human Psuedoarthrosis Tissue Contains in Rat Fracture Healing Osteoprogenitor Cells in Vitro Takashi Iwakura, Takahiro Niikura, Sang Yang Lee, Shunsuke Takahara, Takahiro Niikura, Sang Yang Lee, Etsuko Okumachi, Takahiro Waki, Shunsuke Takahara, Takashi Iwakura, Etsuko Okumachi, Takahiro Waki, Michio Michio Arakura, Yoshitada Sakai, Ryosuke Kuroda, Arakura, Ryosuke Kuroda, Masahiro Kurosaka Masahiro Kurosaka Poster No. 0658 Poster No. 0649 Assessment of Methods for Rapid Intraoperative Histomorphometric Comparison of Graft Efficacy Concentration and Selection of Marrow-Derived Using a Caprine Chronic Tibial Defect Model Connective Tissue Progenitors for Bone Regeneration AlexAnne Weinzierl, Ferenc Toth, Grace Elizabeth Pluhar, using the Canine Femoral Multi-Defect Model George Muschler, Joan Bechtold, Viviane Luangphakdy, Viviane Luangphakdy, Cynthia Boehm, Hui Pan, Phil Zaveri, Cathy S Carlson James Herrick, George Muschler

Poster No. 0650 Poster No. 0659 C haracterization of Composition and Structure of R everse Dynamization Efficiently Heals Large Callus Tissue in Fractures Treated with BMP-7 and Segmental Bone Defects Using a Reduced Dose Zoledronate in an Osteoporotic Rat Model of BMP-2 Neashan Mathavan, Mikael Turunen, Martin Bech, Florian Vaida Glatt, Nicole Loechel, Nicholas Quirk, Michael Schaff,U lf Olsson, Magnus Tagil, Hanna Isaksson Schuetz, Chris Evans

Poster No. 0651 Poster No. 0660 O steogenic Potential of Teriparatide Adjuvant Therapy D evitalized Cartilage Allografts Promote Improved in Surgical Treatment of Femoral Fracture Vascular Remodeling Compared to Bone Allograft in Hong Suk Kwak, Soong Joon Lee, Hee Joong Kim, Jeong Murine Tibia Defects Joon Yoo Aaron J Taylor, Yotvat Marmor, Diane P Hu, Jaselle Perry, Hayley M Britz, Avi D Stricker, Benedikt Hallgrimsson, Poster No. 0652 Theodore Miclau, Ralph S Marcucio, Chelsea S Bahney N ormobaric Oxygen Treatment Improves Fracture Healing After A Blunt Chest Trauma In Mice Poster No. 0661 Julia Kemmler, Ronny Bindl, Florian Wagner, Oscar L ocal Transplantation Of CD31+ Cells From Peripheral MacCook, Katja Wagner, Michael Gröger, Enrico Calzia, Blood Improves Biologically Impaired Bone Healing By Peter Radermacher, Anita Ignatius Modulation Of Early Inflammation And Angiogenesis Anke Dienelt, Andrea Sass, Katharina Schmidt-Bleek, Poster No. 0653 Sebastian Filter, Agnes Ellinghaus, Georg Duda Inhibition Of Microrna-222 Expression Accelerates Bone Fracture Healing With Enhancement Of Poster No. 0662 POSTERS Angiogenesis And Osteogenesis In Atrophic Electronic Distraction Force Measurements to Non-union Model In Rat Optimize Segmental Transport in an Ilizarov Fixator Masaaki Yoshizuka, Tomoyuki Nakasa, Matthias Muench, Klaus DE Seide, Birgitt Kowald, Ulf J Yoshitaka Kawanishi, Mitsuo Ochi Gerlach

Poster No. 0654 PS1 Bone Fracture - Mechanics and Computational E ffect of Plates in Proximity to Empty External Fixation Modeling Pin Sites on Long Bone Torsional Strength Fred L Speck, Randal P. Morris, Ronald W. Lindsey Poster No. 0663 T he Relationship Between Elevated Contact Stress and Poster No. 0655 Clinical Outcome Following Intra-Articular Calcaneal B iomechanical Comparison of Conventional versus Fractures Cable Pin Fixation for Transverse Patellar Fractures Kevin N Dibbern, Saran Tantavisut, Andrew M Kern, J. L. Aaron D Schrayer, Randal P. Morris, Andrew G. Patton, Marsh, Donald Anderson William L. Buford, Ronald W. Lindsey Poster No. 0664 O steochondral Allograft Matching by Radius of Curvature Craig O’Neil, Jesal Parekh, Derick Bernstein, Hugh L Jones, Philip C Noble, Patrick McCulloch 76 Poster No. 0665 PS1 Spine - Scoliosis Would A Proximal Tibial Locked Plating System Or Cannulated Screws Allow Postoperative Weight Poster No. 0676 Bearing On A Surgically Stabilized Schatzker I Tibial Clinical Sagittal Spinal Balance Reliably Quantified Plateau Fracture? An In Silico Pre-check with Center of Mass in Surface Topography for Gaetan Chary, Ion Carrera, Pablo E Gelber, Joan Carles Adolescent Idiopathic Scoliosis Monllau, Jerome Noailly Jessica Küpper, Gulshan Sharma, Chukwudi Chukwunyerenwa, Adrienne Kline, Jason Howard, Ron Poster No. 0666 El-Hawary, Ali Melia, Tyler Dubetz, Elaine Joughin, James Use of Finite Element Analysis to Predict the Fatigue Harder, Janet Ronsky Strength of Cephalomeduallary Nail Systems Michael Bushelow, Stanley J. Kmiec, Brian Shultzabarger, Poster No. 0677 Roderick McMillan, Dana J Coombs, Michael Blauth Association of Vertebral Bone Marrow Edema with Low Back Pain in Degenerative Lumbar Scoliosis in the Poster No. 0667 Elderly: A Cross-sectional Observational Study Comparison of Statically Locked Proximal Lag Toshio Nakamae, Yoshinori Fujimoto, Kiyotaka Yamada, Screws in Cephalomedullary Nail Systems Osami Suzuki, Takashi Hashimoto, Masaki Matsuura, Taiki Brian Shultzabarger, Michael Bushelow, Dana Pappalardo, Morisako Robert Harris Poster No. 0678 Poster No. 0668 Wear Of Spinal Guided Growth Sliding Titanium Lsz-4d Dynamic Hip Screw Hole Placement vs Bone Strain Implants For Early Onset Scoliosis Treatment Dana J Coombs, Michael Bushelow Elena Lukina, Mikhail Kollerov, Jay Meswasnia, Peter Mason, Paul Wagstaff, Aleksandr Laka, David Wertheim, Poster No. 0669 Hilali Noordeen, Wai Yoon, Gordon Blunn Comparison of Intra-operative Radiation Exposure during Intramedullary Nailing between Free-hand Poster No. 0679 Technique and Electromagnetic Assisted Technique Does Pedicle Fill Affect Pull-out Strength after Rod Hiroki Kobayashi Reduction during Scoliosis Surgery? Kevin Albanese, Nathaniel R Ordway, Brandon Clair, Poster No. 0670 Stephen A Albanese, William F Lavelle Time Course of Bone Screw Fixation Following a Local Delivery of Zoledronate in a Rat Femoral Model Poster No. 0680 Ulrike Kettenberger, Adeliya Latypova, Alexandre Terrier Factors Affecting the Interface Strength of Pedicle Screws in the Thoracolumbar Spine Poster No. 0671 Nathaniel R Ordway, Kevin M. Albanese, Development of a Novel Augmentation Pattern of Stephen A. Albanese, William F Lavelle Femoroplasty to Prevent Hip Fracture-Using Finite Element Methods Poster No. 0681 Qiang Luo, Frankie Leung Influence Of Back Extensor Strength On The Natural History Of Kyphosis Without Fresh Vertebral Fractures PS1 Spine - Computational Modelling Michio Hongo, Naohisa Miyakoshi, Yuji Kasukawa, Yoshinori Ishikawa, Daisuke Kudo, Yoichi Shimada Poster No. 0672 A Computational Model of Annulus Fiber Deformation Poster No. 0682 in Cervical Discs During In Vivo Dynamic Flexion\ Spine Growth Modulation Using Titanium Extension, Rotation and Lateral Bending Clip/Screw Device: Curvature, Vertebral and William Anderst, Mara Palmer, Joon Lee, William Disc Height Changes at 1 Year Donaldson, James D Kang Donita I Bylski-Austrow, Nana Entsuah, David L Glos, Joseph E Reynolds, Eric Wall

Poster No. 0673 POSTERS S everity of Adjacent Disc Disease Due to Lower Poster No. 0683 Lumbar Fusion Depends on the Adjacent Segment’s Comparison of Uniplanar Versus Fixed Pedicle Degenerative Grade Screws in the Restoration of Thoracic Kyphosis in the Raghu N Natarajan, Gunnar B Andersson Treatment of Adolescent Idiopathic Scoliosis (AIS) Siddarth Badve, Ryan C Goodwin, David Gurd, Thomas Poster No. 0674 Kuivila, William F Lavelle C hanges in Adjacent Segment Biomechanics After Laminectomy and Laminotomy in Lumbar Spine PS1 Spine - Peripheral Nerve and Spinal Cord Injury Shady Elmasry, Shihab Asfour, Joseph Gjolaj, Loren Latta, Francesco Travascio, Frank Eismont Poster No. 0684 Amiloride Promotes Oligodendrocyte Survival And Poster No. 0675 Remyelination After Spinal Cord Injury In Rats Pedicle Subtraction Osteotomy Rods: Takeshi Imai Surgical Skills Module Robin Parrish, William Camisa, Jeremi Leasure 77 Poster No. 0685 Poster No. 0694 Local Application Of The Sympathetic Nerve Blocker Quantifying the Spatial Distribution of Intradiscal Around The Dorsal Root Ganglion Reduces Painful Pressure and its Assessment via Non-Invasive Behavior In A Lumbar Radiculopathy Model Estimates of Intervertebral Disc Degeneration Izaya Ogon, Tsuneo Takebayashi, Katusmasa Tanimoto, Alexander M DelMonaco, Timothy M Jackman, Paul M Fein, Yoshinori Terashima, Tsuyoshi Miyakawa, Takehito Iwase, Alexander M Adams, Kamil K Makhnejia, Elise F Morgan Takeshi Kobayashi, Noritsugu Tohse, Toshihiko Yamashita Poster No. 0695 Poster No. 0686 Influence of Trypsin Induced Protein Denaturation on Circulating Microrna Expression As A Biomarker For Dynamic Mechanical Properties of Intervertebral Disc Early Diagnosis Of Severity In Spinal Cord Injury Zong-Xing Chen, Yun-Chen Chiu, Yu-Chun Hsu, Pen-hsiu Susumu Hachisuka, Naosuke Kamei, Satoshi Ujigo, Shigeru Grace Chao, Andy Chien, Jaw-Lin Wang Miyaki, Mitsuo Ochi Poster No. 0696 Poster No. 0687 Biomechanical Analysis of the Effect of Posterior Changes in Systemic Biomarkers are Correlated with Compared with Anterior Interbody Cage Positioning Improvement in Pain in Patients Treated with Epidural on Sacral Screw Strain in Long Posterior Spinal Steroid Injection for Lumbar Disc Disorders Fixation Constructs for Anterior Lumbar Shina Satoh, Shaheda Quraishi, KT Weber, Justin Vironjapa, Interbody Fusion Bruce Volpe, Ona Bloom, Nadeen Chahine Ryan Larsen, William Camisa, Jeremi Leasure

Poster No. 0688 PS1 Spine - Spine Therapeutics (Clinical) Histological Comparison Between Pre- And Postganglionic Injuries Of The Brachial Plexus Poster No. 0697 ORS Best Spine Poster In A Rat Model Progressive Pattern of Vertebral Deformity in a Takashi Noguchi, Souichi Ohta, Yukitoshi Kaizawa, Ryosuke Population-based Cohort Study of Vertebral Fracture: Ikeguchi, Hiroki Oda, Ryosuke Kakinoki, Shuichi Matsuda Association with Bone Mineral Density Junichi Yamada, Koji Akeda, Norihiko Takegami, Toshihiro Poster No. 0689 Kato, Koichiro Murata, Akinobu Nishimura, Ko Kato, Receptor-interacting Protein Kinases Mediate Akihiro Sudo Necroptosis In Neural Tissue Damage After Spinal Cord Injury Poster No. 0698 Haruo Kanno, Hiroshi Ozawa, Satoshi Tateda, Changes Of Residual Disc Bulging After Kenichiro Yahata, Eiji Itoi Successful Lumbar Microdiscectomy On Postoperative MR Imaging PS1 Spine - Disc Mechanics Shigeru Kobayashi, Tsuyoshi Miyazaki, Riya Kosaka, Katsuhiko Hayakawa, Adam Meir Poster No. 0690 Muscle Activity Costs of Cervical Sagittal Imbalance Poster No. 0699 Saeed Khayatzadeh, Robert M. Havey, Muturi Muriuki, Spinous Process Fractures after Placement of an Dale Schuit, Leonard I. Voronov, Alexander J. Ghanayem, Interspinous Process Spacer Device: Insight into the Avinash G. Patwardhan Mode of Action of an Interspinous Device William F Lavelle, Fred H Geisler Poster No. 0691 Differential Effects of Nucleolytic Insults on Poster No. 0700 Intervertebral Disc and Function Assessed by Anatomical Evaluation Of The Screw Placement With POSTERS 3-Dimensional Contrast-enhanced Micro-computed Sacral Plate Related To Nerve Injury In Lumbosacral tomography Fixation - Comparison Of Clinical With Cadaver Study Kevin Lin, Simon Y Tang Seiji Otsuka, Muneyoshi Fukuoka, Jun Mizutani, Nobuyuki Suzuki, Yoshihisa Matsumoto, Takanobu Otsuka Poster No. 0692 P opulation Average T2 MRI Maps Reveal Quantitative Poster No. 0701 Regional Transformations in the Degenerating Rabbit Single Level Lumbar Fusion For Degenerative Disc Intervertebral Disc that Vary by Lumbar Level Disease Is Associated With Worse Outcomes Compared John T Martin, Christopher M Collins, Kensuke Ikuta, To Fusion For Spondylolisthesis In A Workers’ Robert L Mauck, Dawn M Elliott, Yejia Zhang, D. Greg Compensation Setting Anderson, Alexander R Vaccaro, Todd J Albert, Vincent Joshua T Anderson, Peter A. Surace, Uri M. Ahn, Nicholas U. Arlet, Harvey E Smith Ahn

Poster No. 0693 Poster No. 0702 Effect of Glycation on the Biochemical and The Difference of Regional Bony Quality in Cervical Biomechanical Properties of Intervertebral Disc Vertebra to Find a Trajectory for Freehand Technique Li-Yu Lin, Yun-Chen Chiu, Yu-Chun Hsu, Pen-hsiu Grace of Pedicle Screw Fixation Chao, Jaw-Lin Wang Dai-Soon Kwak, Moon-Kyu Kim

78 Poster No. 0703 Poster No. 0711 Extreme Lateral Interbody Fusion For Unilateral GDF -6, Hypoxia and Load Act Synergistically to Symptomatic Vertical Foraminal Stenosis Promote Matrix Formation in Mesenchymal Stem Cell Marjan Alimi, Christoph Hofstetter, Apostolos J Tsiouris, Tissue Engineered Nucleus Puloposus Constructs Eric E Elowitz, Roger Härtl Louise E Clarke, Stephen M Richardson, Judith A Hoyland

Poster No. 0703A Poster No. 0712 Can Internet Information on Vertebroplasty be a D ynamic Loading, Matrix Maintenance And Cell Reliable Means of Patient Self-education? Injection Therapy Of Human Intervertebral Discs T. Barrett Sullivan, Joshua T Anderson, Peter A. Surace, Cultured In A Bioreactor. Uri M. Ahn, Nicholas U. Ahn Derek H Rosenzweig, Janet Moir, Rahul Gawri, David Eglin, Michael Weber, Jean Ouellet, Thomas Steffen, Lisbet PS1 Spine - Spine Therapeutics (In vivo Preclinical) Haglund

Poster No. 0704 Poster No. 0713 Acute Hyperglycemia Is A Treatable Risk Factor T hermally Triggered Injectable Hydrogel Which For Spinal Cord Injury: Animal Experiment And Induces Mesenchymal Stem Cell Differentiation To Human Cohort Study Promote Regeneration Of The Intervertebral Disc Kazu Kobayakawa, Kensuke Kubota, Kazuya Yokota, Abbey A Thorpe, Victoria Boyes, Chris Sammon, Christine L Seiji Okada, Yukihide Iwamoto Le Maitre

Poster No. 0705 Poster No. 0714 Inhibition of NF-κB Signaling in Annulus Fibrosus Effect of Priming and Structured Co-culture of Cells Decreases Prostaglandin E2 Production in Microencapsulated Bone Marrow and Adipose Tissue Response to Combined Mechanical Loading and Derived Stem Cells for Disc Repair Inflammatory Stimulation Syeda Masooma Naqvi, Conor T Buckley Robert Tisherman, David Phillibert, Joao P Coelho, Nam Vo, Gwendolyn Sowa, James D Kang Poster No. 0715 P reconditioning Stem Cells to Maximize Regenerative Poster No. 0706 Potential in the Challenging Microenvironment of the Rapamycin Suppresses Microglial Activation and Intervertebral Disc Reduces inflammation after Spinal Cord Injury in Mice Katherine E Lothstein, Philip J.M. O’Donnell, Sun H Peck, Satoshi Tateda, Haruo Kanno, Hiroshi Ozawa, Akira George R Dodge, Robert L Mauck, Neil R Malhotra, Lachlan Sekiguchi, Kenichiro Yahata, Seiji Yamaya, Eiji Itoi J Smith

Poster No. 0707 Poster No. 0716 Clonal Human Embryonic Progenitor Cell Line C rosslinking Density Impacts Human Mesenchymal Injections Facilitate Intervertebral Disc Repair and Stem Cell Differentiation and Associated Reduce Nerve Root Pain in In Vivo Animal Models Nucleus Pulposus-like Matrix Assembly in Daisuke Sakai, Rajeswari Pichika, Tomonori Yamaguchi, Carboxymethylcellulose Hydrogels Shintaro Shoju, Hitoshi Nemoto, Won Bae, Carol Huizi Anna Lin, Michelle S Gupta, Devika M Varma, Steven Muehleman, Joji Mochida, Hal Sternberg, B Nicoll Francois Binette, Koichi Masuda Poster No. 0717 Poster No. 0708 T he Role of MHC Class Receptors on the Function of PDGF-BB Treatment for Mid-stage IVD Degeneration Tissue Engineered IVDs Made with Human MSCs Inhibits Apoptosis and Preserves Disc Katherine Hudson, Peter Grunert, Sara Towne, Roger Hartl, Architecture In a Rabbit Model Lawrence Bonassar David N. Paglia, Teja Karukonda, Hicham Drissi, Isaac L Moss Poster No. 0718

P re-differentiation of Human Adipose Mesenchymal POSTERS PS1 Spine - Disc, Tissue Engineering and Repair Stem Cells to a Discogenic Phenotype Protects Against the Catabolic Effects of IL-1 Poster No. 0709 Louise E Clarke, Stephen M Richardson, Judith A Hoyland Human Mesenchymal Stem Cells Display Anti- inflammatory and Anti-catabolic Properties in Poster No. 0719 Response to Degenerate Human Nucleus Pulposus Synergic Effects of Hypoxic Isolation-Expansion and Cells within a Degenerate Intervertebral Disc-Like Lovastatin Pretreatment on Human Degenerative Microenvironment Nucleus Pulposus Cells Improves Properties of Stephen M Richardson, Pauline Baird, Judith A Hoyland Regenerative Matrix Shu-Hua Yang, Ming-Hsiao Hu, Yuan-Hui Sun Poster No. 0710 T he Influence of TGF-β3 on the Maturation of Tissue Engineered IVDs Containing Highly Contractile Human MSCs Katherine Hudson, Priya Baraniak, Jon Rowley, Lawrence Bonassar 79 Poster No. 0720 Poster No. 0729 Long-term Efficacy of Cell Therapy for Intervertebral Disc Gene Therapy: Development Of A Novel Disc Repair: Quantitative Analysis Inducible System To Regulate Expression Of The Qiaoqiao Zhu, Xin Gao, Thomas H Temple, Therapeutic Transgene Timp1 Mark Brown, Weiyong Gu Zhihua Ouyang, Wenjun Wang, Adam H Richman, Qing Dong, Wan Huang, Ying Tang, Bing Wang, Nam Vo, Poster No. 0721 Gwendolyn Sowa, James D Kang Dynamic Tracking Of Il-6 Transcription In Nucleus Pulpous Cells In Vitro Poster No. 0730 Xinyan Tang, Dezba Coughlin, Erik Waldorff, Characterization Of Senescent Intervertebral Disc James Ryaby, Tamara Alliston, Jeffrey Lotz Cells: Secretion Of Catabolic Factors And Proteolysis Of Matrix Aggrecan Poster No. 0722 Kevin Ngo, Gwendolyn Sowa, James D Kang, Nam Vo Hepatocyte Growth Factor/c-Met Has Proliferation- promoting And Anti-apoptosis Effects On Rabbit Poster No. 0731 Nucleus Pulposus Cells In Vitro Rapamycin, a mTORC1 Inhibitor, Protects the Hidenobu Ishibashi, Takumi Ikeda, Hitoshi Tonomura, Intervertebral Disc Against Cellular Apoptosis, Munehiro Sakata, Masateru Nagae, Yasuo Mikami, Senescence, and Extracellular Matrix Degradation Hiroyoshi Fujiwara, Takashi Tanida, Ken-ichi Matsuda, Through Akt Activation Rather Than Mitsuhiro Kawata, Toshikazu Kubo Autophagy Induction Takashi Yurube, Thomas P Lozito, Robert A Hartman, Pedro Poster No. 0723 H. I. Pohl, Zhongying Zhang, Kotaro Nishida, Masahiro A Quantitative Analysis of Lumbar Discectomy Kurosaka, Nam V Vo, James D Kang, Gwendolyn A Sowa Using Two Surgical Techniques During a Simulated TLIF Procedure Poster No. 0732 Nathaniel R Ordway, William F Lavelle, Ali Araghi, Chloroquine Increases Disc Cellular Apoptosis, Rudolph Buckley, Amir H Fayyazi Senescence, and Extracellular Matrix Degradation: Possible Adverse Effects of Inhibiting Autophagic Flux Poster No. 0724 Takashi Yurube, Thomas P Lozito, Kotaro Nishida, Masahiro Accuracy of Fluoroscopy vs. Computer-Assisted Kurosaka, James D Kang, Gwendolyn A Sowa Navigation for the Placement of Anterior Cervical Pedicle Screws Poster No. 0733 Andrew G Patton, Randal P. Morris, Yong-Fang Kuo, Gene Expression ProfilingI dentifies Interferon Ronald W. Lindsey Signaling and IGFBP3 as Mediators in Human Intervertebral Disc Degeneration PS1 Spine - Disc Biology Zepur Kazezian, Rahul Gawri, Lisbet Haglund, Jean Ouellet, Fackson Mwale, Peadar OGaora, Poster No. 0725 Abhay Pandit, Mauro Alini, Sibylle Grad T he Role of Class 3 Semaphorins in Innervation and Angiogenesis within the Degenerate Poster No. 0734 Human Intervertebral Disc Proinflammatory Cytokines Regulate Abbie L A Binch, Ashley A Cole, Lee M Breakwell, Antony Mineralization in Bovine Nucleus Pulposus Cells LR Michael, Neil Chiverton, Alison K Cross, Robert J Frawley, Agata K Krzyzanowska, Sheela Damle, Christine L Le Maitre Matthew Cunningham

Poster No. 0726 Poster No. 0735 POSTERS Large Cohort Investigation of Nerve and Blood Vessel Tnfκ Is Correlated With Trpv4 Expression Ingrowth into Human Intervertebral Discs In The Intervertebral Disc Abbie L A Binch, Ashley A Cole, Lee M Breakwell, Benjamin A Walter, Jessica Occhiogrosso, Devina Antony L R Michael, Neil Chiverton, Laura B Creemers, Purmessur, Damien M Laudier, Andrew Moon, Alison K Cross, Christine L Le Maitre Andrew C Hecht, James C Iatridis

Poster No. 0727 Poster No. 0736 The Effects of Substance P Administration on the Progranulin Deficiency Causes Intervertebral Disc Intervertebral Disc in a Rat Organ Culture Model Degeneration in Aging Mice John D Koerner, Dessislava Markova, Gregory D Schroeder, Jianlu Wei, Yunpeng Zhao, Qingyun Tian, Chuanju Liu Alexander R Vaccaro, Todd J Albert, D. Greg Anderson, Christopher K Kepler Poster No. 0737 The Effect of Omega-3 Fatty Acids on the Poster No. 0728 Responses of Intervertebral Disc Cell to Inflammation Matrix Metalloproteinase MMP12 is Associated with Zhongying Zhang, Carolyn Moore, Nam Vo, James D Kang, Intervertebral Disc Degeneration Gwendolyn A Sowa Fengjuan Lv, Yan Peng, Foon Liam Lim, Yi Sun, Lixiong Zhou, Kenneth Cheung, Victor Leung

80 Poster No. 0738 Poster No. 0746 ProinflammatoryC ytokines Modulate the Chemokine Anterior Cervical Decompression and Fusion: Influence CCL2 (MCP-1) in Human Annulus Cells in Vitro: CCL2 of Surgical Levels and Morphological Factors on the Expression and Production Range of Motion and Kinematical Changes Helen Elizabeth Gruber, Gretchen Hoelscher, Synthia Chia-Hao Hsieh, Dar-Ming Lai, Andy Chien, Chia-Ching Lin, Bethea, Jane Ingram, Michael Cox, Edward Hanley Wen-Kai Chou, Zong-Xing Chen, Jaw-Lin Wang

Poster No. 0739 Poster No. 0747 High-Mobility Group Box-1 Gene, a Potent Comparative Analysis of Cervical Kinematics, Pain and Proinflammatory Mediator, Is Upregulated in More Functional Disability Between Single- and Two-level Degenerated Human Discs in Vivo and Its Receptor Is Anterior Cervical Discectomy and Fusion Upregulated by TNF-κ Exposure in Vitro Andy Chien, Dar-Ming Lai, Shwu-Fen Wang, Wei-Li Hsu, Helen Elizabeth Gruber, Gretchen Hoelscher, Synthia Chih-Hsiu Cheng, Jaw-Lin Wang Bethea, Jane Ingram, Michael Cox, Edward Hanley Poster No. 0748 Poster No. 0740 Intervertebral Cervical Spine Kinematics During In Degenerating Discs Secrete Increased Concentrations Vivo Dynamic Loading: Continuous Motion Paths of CHI3L1 and CHI3L2, Which Are Regulated by Defined Using Bootstrap Prediction Bands Inflammatory Cytokines and Toll-like Receptors W illiam Anderst, Maya McKeown Emerson Krock, Joan B Currie, Michael H Weber, Peter Jarzem, Anneliese D Recklies, Jean A Ouellet, Poster No. 0749 Lisbet Haglund Variable Stiffness Cervical Plates Affect Load Sharing in the Interbody Space In Vitro Poster No. 0741 Joshua Peterson, Carolyn Chlebek, Karl Meier, Eric H Ledet Effects of Nicotine on Inflammasome ctivationA in Human Nucleus Pulposus and Annulus Fibrosus Cells Poster No. 0750 Frank J. Brand III, Francesco Travascio, Intervertebral Kinematics Correlate with T2 Relaxation Juan Pablo de Rivero Vaccari Times in the Lower Human Cervical Spine Sean J. Driscoll, Shaobai Wang, Weiye Zhong, Martin Poster No. 0742 Torriani, Guoan Li, Kirkham B Wood, Thomas D Cha Correlation of Outcomes and Intradiscal Cytokine Expression in Lumbar Fusion Patients Poster No. 0751 Christopher K Kepler, Dessislava Markova, John D Koerner, Loss of Cervical Deep Muscle Function Is Associated Joseph Mendelis, Gregory Schroeder, Alexander R Vaccaro, with An Increase in Cervical Kyphosis after D. Greg Anderson Laminoplasty Surgery: In-Vitro Experimental Spine Model with Muscle Function Simulation Poster No. 0743 Wen-Kai Chou, Andy Chien, Zong-Xing Chen, Chia-Hao Effects of Toll-Like Receptor 4 Activation on the Hsieh, Li-Yu Lin, Jaw-Lin Wang Nucleus, Cytoskeleton and Mechanobiology of Intervertebral Disc Cells Poster No. 0752 Paula Hernandez, Timothy Jacobsen, Victoria Wei, Influence Of Stepwise Removal Of UHMWPE Nadeen O. Chahine Sublaminar Wires On Segmental Stability In Long Segment Instrumentation For Early Poster No. 0744 Onset Scoliosis Correction M1 and M2c Macrophage Phenotypes in Alex K Roth, Albert van der Veen, Rob Bogie, Intervertebral Disc Degeneration Paul Willems, Chris Arts, Lodewijk W van Rhijn Kenneth R Nakazawa, Benjamin A Walter, Thomas P Naidich, Kara L Spiller, James C Iatridis Poster No. 0753 Evaluation Of Trunk Kinematics Asymmetry Poster No. 0744A Between Convex Side And Concave Side In

Role Of Circulating Signals In The Control Of Postnatal Degenerative Lumber Scoliosis POSTERS Intervertebral Disc Growth And Differentiation Kaoruko Ito, Mitsuhiro Nishida, Kota Watanabe, Morio Sarah Loh, Eric Mahoney, Christopher Wylie, Chitra L Dahia Matsumoto, Yoshiaki Toyama, Takeo Nagura

PS1 Spine - Mechanics Poster No. 0754 Maintaining Lordosis Angle Is a Critical Factor for Safe Poster No. 0745 Disc Decompression in Conservative Spine Traction In-vivo Motion Characteristics Of The C5-C6 And C6-C7 Exercise for Treating Low Back Pain Cervical Spine Segments During Dynamic Weight- Won Man Park, Dae Kyung Choi, Kyungsoo Kim, bearing Flexion-Extension Yoon Hyuk Kim, Jae Lak Yang Sean J. Driscoll, Shaobai Wang, Weiye Zhong, Guoan Li, Kirkham B Wood, Thomas D Cha

81 Poster No. 0755 Poster No. 0764 Thoracic Spine Motion as a Function of Sex-Specific Variations in Passive Knee Rotation Disc Degeneration and Posterior under Unconstrained Axial Plane Torques Destabilization Procedures A ta M Kiapour, Samuel C Wordeman, Vijay K Goel, Sean L Borkowski, Sophia N Sangiorgio, Patricia A Carmen E Quatman, Timothy E Hewett, Campbell, Timothy L Tan, Richard E Bowen, Anthony A Constantine K Demetropoulos Scaduto, Edward Ebramzadeh Poster No. 0765 Poster No. 0756 Can Medial Compartment Contact Forces in an The Influence of Previous Low Back Pain and ACL DeficientK nee Be Lower Despite Higher Muscle Sex on Trunk Flexor Endurance at Various Work Loads Co-contraction? Lauren C Thomas, Seth Oberst, Christopher Wall, Lindsey Ashutosh Khandha, Elizabeth Wellsandt, Kurt Manal, Adam Russell, Kerry McFadden, David Russ, Brian Clark, Marmon, Lynn Snyder-Mackler, Thomas Buchanan James S Thomas Poster No. 0766 Poster No. 0757 The Joint Moment Distributions of the Lower Extremity Fretting Corrosion Response of Spinal Fixation Devices during Gait in Patients after Open Reduction and with CoCrMo Rods of Different Surface Roughness Internal Fixation of Acetabular Fractures Sachin A Mali, Aarti A Shenoy, Vaneet Singh, William Tucker, Justin McCormick, Aaron Mates, Wei Liu, Jeremy L Gilbert Jorge Alonso

Poster No. 0758 Poster No. 0767 Axial Torsion Alters Load Distribution Alterations in Knee Contact Forces and Contact Centers Among Spinal Components In Flexion/extension During Gait in Normal, OA and Varus-Valgus Altered In Rabbit Lumbar Spinal Segments Subjects -A Detailed Lower Extremity Musculoskeletal Robert A Hartman, Robert T Tisherman, Kevin M Bell, Model Study Richard E Debski, James D Kang, Gwendolyn Sowa M Adouni, A Shirazi-Adl

PS1 Spine - Biology Poster No. 0768 The Accuracy of Personal Activity Monitoring Devices Poster No. 0759 Andrew K. Battenberg, Donohoe Steven, Nicholas Making Connections In Spinal Mechanobiology: Robertson, Thomas P Schmalzried Mechanical Properties As Predictors Of Biological Responses Poster No. 0769 Robert A Hartman, Bryan Brown, Richard E Debski, In-vivo Kinematics of Posterior-Stabilized Total Knee James D Kang, Gwendolyn Sowa Prosthesis Designed For Japanese Toshifumi Watanabe, Takeshi Muneta, Ichiro Sekiya, Poster No. 0760 Hideyuki Koga, Masafumi Horie, Tomomasa Nakamura, P athogenesis Of The Hypertrophied Koji Otabe, Scott A Banks Ligamentum Flavum In LSCS Yutaka Yabe, Yoshihiro Hagiwara, Akira Ando, Masahiro Poster No. 0770 Tsuchiya, Takashi Minowa, Taro Takemura, Masahito Sex Differences in Knee Valgus Rotation under Honda, Kazuaki Sonofuchi, Kenji Kanazawa, Masashi Koide, Unconstrained Single- and Multi-Planar Loading: Takuya Sekiguchi, Nobuyuki Itaya, Eiji Itoi Implications for Valgus Collapse ACL Injury Mechanism Ata M Kiapour, Carmen E Quatman, Samuel C Wordeman, Poster No. 0761 Vijay K Goel, Constantine K Demetropoulos, POSTERS India Hedgehog is correlated to Human Timothy E Hewett Endplate Cartilage Degeneration Shaowei Wang, Yaqiong Chang, Lei Wei, Poster No. 0771 Guoqing Du, Shunwu Fan Knee Osteoarthritis AffectsT he Recovery Stepping Response Following A Large Postural Perturbation PS1 Knee - Kinematics and Gait Mackenzie L Pater, Noah J Rosenblatt, Mark D Grabiner

Poster No. 0762 Poster No. 0772 The Hip Internal Rotation is Negatively Correlated to Biomechanical Assessment of Three Patellar Valgus Knee Motion and Internal Tibial Rotation in the Advancement Procedures for the Treatment of Patella Early Phase during a Landing Task in Drop Jumping Alta in Children with Cerebral Palsy Tomoya Ishida, Masanori Yamanaka, Shohei Taniguchi, Ryo Adam Seidl, Todd Baldini, Jason Rhodes, James Carollo Ueno, Shigeyuki Minami, Yuta Koshino, Mina Samukawa, Hiroshi Saito, Takumi Kobayashi, Hisashi Matsumoto, Poster No. 0773 Yoshimitsu Aoki, Harukazu Tohyama Knee Function Classification: Is it Possible To Identify Factors That Contribute To Total Knee Replacement Poster No. 0763 Outcome? Gait Normalizes At Fast Walking Speeds In Daniel Watling, Paul Biggs, Andrew Metcalfe, Christopher People With Knee Osteoarthritis Wilson, Gemma M Whatling, Cathy A HOLT Victoria L Manning, Michela Zanotto, Adeel Aqil, 82 Justin Cobb Poster No. 0774 Poster No. 0784 The Effect of Contralateral Cane on the Knee Three-dimensional Lower Extremity Alignment and Thorax Biomechanics in Patients after In The Weight-bearing Standing Position In Total Knee Arthroplasty Osteoarthritis Subjects Hidenori Tanikawa, Tomonori Muto, Ryo Ogawa, Toshihide Fujii, Takashi Sato, Satoshi Watanabe, Kengo Harato, Kazunari Okuma, Takeo Nagura Naoto Endo

Poster No. 0775 Poster No. 0785 Single Radius Versus Multi Radii CR TKA Kinematics Tibiofemoral Contact Mechanics following a Trevor F Grieco, Harold Cates, Adrija Sharma, Horizontal Cleavage Lesion in the Posterior William Hamel, Richard D Komistek Horn of the Medial Meniscus Sally Arno, Christopher Bell, Carlos Uquillas, Poster No. 0776 Ilya Borukhov, Peter S Walker Relationships Between Femoral Tunnel position and Dynamic Knee Function After ACL Reconstruction Poster No. 0786 Yuichiro Nishizawa, Eric Thorhauer, James J Irrgang, Evaluation Of The Compositional And Functional Freddie H Fu, Scott Tashman Properties Of Articular Cartilage Using T1rho And T2 Relaxation Imaging Poster No. 0777 Amber T. Collins, Sophia Y Kim, Courtney E Cox, Sophia In Vivo Kinematics for Subjects Implanted With Either a Ziemian, Charles E Spritzer, Farshid Guilak, Amy L McNulty, Traditional or a Customized, Individually Made TKA Louis E DeFrate Ian M Zeller, William B Kurtz, William R Hamel, Matthew A Young, Mathew R Anderle, Richard D Komistek Poster No. 0787 The Porcine Knee as a Sex-Specific Model to Study Poster No. 0778 Human Anterior Cruciate Ligament Pathology Quantitative Assessment Of Cluster Methods Against Ata M Kiapour, Matthew R Shalvoy, Martha M Murray, Bi-plane Fluoroscopic Method In Measuring Knee Braden C Fleming Kinematics During Treadmill Walking Young-jun Koo, Yoon Kwak, Seungbum Koo Poster No. 0788 Design and Validation of a Smart Knee Fixture for Poster No. 0779 Measuring Knee Balancing Condyle Motion Characteristics of the Knee during Christopher Bell, Patrick A Meere, Peter S Walker, Ilya Dynamic Flexion-Extension Borukhov Yong Feng, Tsung-Yuan Tsai, Jing-Sheng Li, Shaobai Wang, Hai Hu, Changqing Zhang, Harry E Rubash, Guoan Li Poster No. 0789 Does Venting Knee Joint Capsule Affect Laxity in TKA? Poster No. 0780 Erik L. Woodard, Casey T Hebert, Wade C. Gobbell, Preoperative Knee Kinematics Impacts William M. Mihalko Upon Postoperative Knee Kinematics In Total Knee Arthroplasty Poster No. 0790 Naoki Seito, Tomohiro Onodera, Yasuhiko Kasahara, Yusuke Difference Of Graft Tension Pattern Between The Intra- Nishio, Eiji Kondo, Norimasa Iwasaki, Tokifumi Majima And Extra-articular Graft Portion In Anatomic Anterior Cruciate Ligament Reconstruction Poster No. 0781 Kanto Nagai, Ryosuke Kuroda, Yuichi Hoshino, Yuichiro Correlations Between Knee Anatomy and Nishizawa, Daisuke Araki, Shinya Oka, Naoki Nakano, Joint Laxity Using Principle Component Analysis Takehiko Matsushita, Tomoyuki Matsumoto, Koji Sami Shalhoub, Lowell M Smoger, Adam J Cyr, Takayama, Kouki Nagamune, Masahiro Kurosaka Paul J Rullkoetter, Peter J Laz, Lorin P Maletsky PS1 Knee - Computational Modelling PS1 Knee - Mechanics

Poster No. 0791 POSTERS Poster No. 0782 Fluid Flow Properties Of Articular Cartilage Change C an the Entire Boundary of Knee Laxity be Most In Very Early Osteoarthritis Determined by a Few Specific Laxity Measures? Janne TA Mäkelä, Sang Kuy Han, Walter Herzog, Sami Shaloub, Adam J Cyr, Fallon Fitzwater, Rami Korhonen Lorin P Maletsky Poster No. 0792 Poster No. 0783 Importance of Patella, Quadriceps Forces and Depth- The Evaluation Of Intra- And Extra-articular Tension Wise Cartilage Structure on Knee Joint Motion and Of The Graft During The Graft Fixation In Anterior Cartilage Response During Patient-Specific Gait Cycle Cruciate Ligament Reconstruction K immo S Halonen, Mika E Mononen, Jukka S Jurvelin, Kanto Nagai, Ryosuke Kuroda, Yuichi Hoshino, Yuichiro Juha Töyräs, Adam Klodowski, Juha-Pekka Kulmala, Nishizawa, Daisuke Araki, Shinya Oka, Naoki Nakano, Rami Korhonen Takehiko Matsushita, Tomoyuki Matsumoto, Koji Takayama, Kouki Nagamune, Masahiro Kurosaka

83 Poster No. 0793 Poster No. 0804 Predicting Tibial rotation using Biomechanics and Mechanobiology of Osteochondral Multiple Anatomic Landmarks Graft Insertion: Cartilage Damage is Associated with Philip C Noble, Kevin Hwang, Sabir Ismaily, Delivered Energy and Reduced by a Waisted Morteza Meftah, Stephen Incavo, Kenneth Mathis Graft Geometry Alvin W. Su, Dustin H Wailes, Yunchan Chen, Van Wong, Poster No. 0794 Esther Cory, Albert C Chen, William D Bugbee, Robert Sah The Effect of Surgical Placement Parameters on Implant Micromotion with Heterogeneous Patient Poster No. 0805 Specific Bone Properties: a Probabilistic FEA Study Factors Affecting Femoral Tunnel Morphology and Robert Davignon, Michael Ferko, Stuart Axelson Graft Bone Block Healing after Anterior Cruciate Ligament Reconstruction Poster No. 0795 Eric Thorhauer, Yuichiro Nishizawa, James J Irrgang, Laxity Characteristics of the Medial and Lateral Freddie H. Fu, Scott Tashman Compartment in Normal Female and Male Knees Marc Bandi, Eik Siggelkow, Amit M Mane, Iris Sauerberg, Poster No. 0806 Fred Wentorf Can the Area and Distribution of the Bone Marrow Edema in Knee Osteoarthritis be Reduced by a Poster No. 0796 Rotational Knee Exercise Program? WITHDRAWN Kenji Hoshi, Tsukasa Kanda, Akira Nagao, Megumi Yamamoto, Yasuhiko Ohkura, Kazuyoshi Gamada Poster No. 0797 Validation of Patellofemoral Joint Contact Pressure Poster No. 0807 Distribution Driven by Accurate Knee Joint Kinematics Fresh Meniscus with Hemi-Plateau Osteoarticular Jonathan A Gustafson, Kyle A Berkow, Zhaochun Yang, Allografts: Validation and Initial Clinical Results Richard E Debski, Shawn Farrokhi Ferris M. Pfeiffer, James P. Stannard, James L Cook

Poster No. 0798 Poster No. 0808 T he Effect of Cartilage Thickness on Tibiofemoral T he Femorotibial Compressive Force in Total Knee Contact Pressure During Gait Arthroplasty: A Novel Intraoperative Predictor of the Colin R Smith, Rachel Lenhart, Jarred Kaiser, Postoperative Flexion Angle Kwang Choi, Darryl Thelen Go Iida, Tsuyoshi Jotoku, Mikio Nakajima, Yoshinori Okamoto, Shuhei Otsuki, Shyhei Oda, Yoshiaki Hoshiyama, Poster No. 0799 Hidetsugu Ohara, Masashi Neo, Mutsumi Ohue, Hideki Morphological Analysis of Proximal Tibia Using Matsuda, Yoshiaki Miyata Statistical Shape Models Yifei Dai, Jeffery Bischoff Poster No. 0809 Validation of a Portable System for Monitoring Knee Poster No. 0800 Motion During Physical Rehabilitation Knee Bone Shape Features Are Correlated Daniel R Freer, Abhigyan Mukherjee, William D Anderton, With Abnormal Tibial Translation After ACL Robert A Hartman, Shawn Farrokhi, Kevin M Bell Injury And Reconstruction Valentina Pedoia, Keiko Amano, Drew Lansdown, Musa Poster No. 0810 Zaid, Brian Lau, Richard Souza, C Benjamin Ma, Xiaojuan Li R elationships Between Clinical Laxity Measurement and Dynamic Knee Kinematics PS1 Knee - Surgical Repair and Rehabilitation After ACL Reconstruction POSTERS Yuichiro Nishizawa, Eric Thorhauer, James J Irrgang, Poster No. 0801 Freddie H Fu, Scott Tashman The Effect of Different Preconditioning Protocols on Anterior Knee Laxity After ACL Reconstruction PS1 Knee - Knee Ligament with Four Commonly Used Grafts Daniel Boguszewski, Nirav Joshi, Dean Wang, Poster No. 0811 Keith Markolf, Frank Petrigliano, David McAllister P reservation of Remnant Tissue Improves Knee Stability and Graft Healing after Anterior Cruciate Poster No. 0802 Ligament Reconstruction in Sheep Does Mechanism of Injury Affect Gait Biomechanics Tsuneari Takahashi, Eiji Kondo, Yasuyuki Kawaguchi, in Athletes At Return to Activity after ACLR? Jun Onodera, Shin Miyatake, Norimasa Iwasaki, Mathew Failla, David Logerstedt, Lynn Snyder-Mackler Kazunori Yasuda

Poster No. 0803 Poster No. 0812 Smart Patellar Implant for In Vivo Force Reproduction of In-Vivo Gait Using a Novel Measurement Across the Patellofemoral Joint Robotic Manipulator and Accuracy of the Matthew K Dion, Colleen P Healey, Jared Roberts, Tissue Forces Determined Eric H Ledet Mohammad Atarod, Joshua M Rosvold, Cyril Frank, Nigel Shrive

84 Poster No. 0813 Poster No. 0822 Age-dependent Healing Potential Of Anterior Cruciate Utility of Instrumented Knee Laxity Testing in Ligament Remnant-derived Cells Diagnosis of Partial Anterior Cruciate Ligament Tears Naoki Nakano, Tomoyuki Matsumoto, Koji Takayama, Ata M Kiapour, Ali Kiapour, Timothy E Hewett, Vijay K Goel Takehiko Matsushita, Daisuke Araki, Atsuo Uefuji, Kanto Nagai, Shurong Zhang, Takao Inokuchi, Kyohei Nishida, Poster No. 0823 Ryosuke Kuroda, Masahiro Kurosaka The Microscopic Anatomy of the Human ACL Entheses: A Quantitative Analysis Poster No. 0814 Melanie L. Beaulieu, Grace E. Carey, Stephen H. Schlecht, Contribution from Collateral Ligaments to Edward M Wojtys, James A. Ashton-Miller Overall Knee Joint Constraint Adam J Cyr, Sami S Shalhoub, Fallon G Fitzwater, Poster No. 0824 Lauren A Ferris, Lorin P Maletsky Reliability of a 2D Simple Image Analysis Method to Predict 3D Bony Motion of the Lateral Knee Poster No. 0815 Compartment During the Pivot Shift Test Histological Analyses of Early Onset of Fetal Fabio V Arilla, Ata Azar, Benjamin Scott, Daniel Guenther, Double-Bundle Anterior Cruciate Ligament Carlos Yacuzzi, Ricahrd Debski, Volker Musahl Weifeng Yin, Kostas Michail, Jian Li, Monica Linde-Rosen, Fengjin Guo, Ying Tang, Freddie Fu, Bing Wang Poster No. 0825 WITHDRAWN Poster No. 0816 Anterolateral Ligament Injury Increases Poster No. 0826 Tibiofemoral Kinematic Changes Following ACL Injury: Oral Contraceptive Use Predicts Fewer Cruciate A Simulation Study Ligament Reconstructions in Young Females Nicholas A Early, Michael J Kelly, Alexis K Schlosser, Aaron M. Gray, Zbigniew Gugala, Jacques Baillargeon Danielle E Filipkoswski, John J Elias Poster No. 0827 Poster No. 0817 Changes in Cross-Sectional Area of The Human Analysis of Adiopokine mRNAs in Canine Cranial Posterior Cruciate Ligament during Knee Motion Cruciate Ligament and Their Associations with Masataka Fujii, Yoshimasa Fujimaki, Yusuke Sasaki, Cartilage Matrix Markers Takayuki Furumatsu, Shinichi Miyazawa, Toshifumi Ozaki, Wipawee Saengsoi, Simon R. Tew, Chen Bing, Monica Linde-Rosen, Patrick Smolinski, Freddie H Fu Brandan G. Wustefelds-Janssens, Eithne J. Comerford, Alexander J. German Poster No. 0828 Effect Of Graft Size And Insertion Site Area In Single Poster No. 0818 Bundle And Double Bundle Anterior Cruciate Ligament Bone Bridge Between Femoral Bone Tunnels Affects Reconstruction: A Human Cadaver Study Bone Tunnel Enlargement After Anatomic Double- Yusuke Sasaki, Fujii Masataka, Daisuke Araki, Monica Bundle Anterior Cruciate Ligament Reconstruction Linde-Rosen, Patrick Smolinski, Freddie H Fu Daisuke Araki, Ryosuke Kuroda, Yosuke Uozumi, Kouki Nagamune, Takehiko Matsushita, Tomoyuki Matsumoto, Poster No. 0829 Koji Takayama, Yuichi Hoshino, Masahiro Kurosaka Factors Associated with Characteristics of Stem-like Cells Derived from Anterior Cruciate Ligament Poster No. 0819 Shurong Zhang, Tomoyuki Matsumoto, Atsuo Uefuji, Evaluation of Partial Transection Versus Synovial Naoki Nakano, Takao Inokuchi, Takehiko Matsushita, Koji Debridement of the ACL as Novel Canine Models for Takayama, Ryosuke Kuroda, Masahiro Kurosaka Management of ACL Injuries Chantelle Bozynski, Keiichi Kuroki, James P Stannard, Poster No. 0830 Patrick Smith, Aaron Stoker, Cristi Cook, James Cook Gait Is a Poor Task Choice for Identifying Kinematic Deficits After CLA Reconstruction

Poster No. 0820 Ruben OHara-Plotnik, Eric Thorhauer, Andrew POSTERS C omparisons of Angular Velocities of Knee Abduction Sivaprakasam, James Irrgang, Freddie Fu, Scott Tashman and Internal Rotation between Female and Male Subjects during a Landing Task PS1 Hip - Disease Process Ryo Ueno, Masanori Yamanaka, Tomoya Ishida, Shohei Taniguchi, Harukazu Tohyama Poster No. 0831 Bone Apatite Composition Of Osteonecrotic Trabecular Poster No. 0821 Bone From The Femoral Head Of Immature Pigs Joint and Epiphyseal Progenitor Cells Revitalize Olumide O Aruwajoye, Harry KW Kim, Pranesh B Aswath Tendon Graft and Form Mineralized Insertion Sites in Murine ACL Reconstruction Model Poster No. 0832 Yusuke Hagiwara, Nathaniel A Dyment, Douglas J Adams, Femoral Perfusion After Electromagnetic Field Shinro Takai, David W Rowe Stimulation In A Steroid-induced Osteonecrosis Model Akira Ikegami, Keiichiro Ueshima, Kazuya Ikoma, Mikihiro Fujioka, Masazumi Saito, Shigeki Hayashi, Masashi Ishida, Masaaki Kuribayashi, Osam Mazda, Toshikazu Kubo 85 Poster No. 0833 Poster No. 0842 Effect Of Corticosteroid In The Development The Influence Of Cartilage Fibrillation On The Contact Of Osteonecrosis Of The Femoral Head Mechanics Of A Biphasic Finite Element Hip Model Shunichiro Okazaki, Satoshi Nagoya, Junya Shimizu, Mikito Junyan Li, Alison Jones, Sophie Williams, Zhongmin Jin, Sasaki, Kenji Tateda, Hiromasa Inoue, Toshihiko Yamashita John Fisher, Ruth Wilcox

PS1 Hip - FAI and Morphology Poster No. 0843 Finite Element Analysis Of Osteonecrosis Of Poster No. 0834 The Femoral Head And Material-characteristics Biomechanical Evaluation of Capsulotomy and Measurement Of Osteonecrosis Capsular Repair in the Hip: Restoring Stability Masamitsu Tomioka, Yutaka Inaba, Naomi Kobayashi, Sang H Song, Thomas H Wuerz, Jeffrey S Grzybowski, Hiroyuki Ike, Haruka Suzuki, Tomoyuki Saito Mitchell J Greenberg, Alejandro A Espinoza-Orias, Shane J Nho Poster No. 0844 In Vivo Kinematic Evaluation Of Cementless Total Hip Poster No. 0835 Arthroplasty During Step-up Activity Radial Imaging Evaluation for Two Types of Cam-Type Dimitris Dimitriou, Tsung-Yuan Tsai, Jing-Sheng Li, Kwan K Femoroacetabular Impingement Hips Park, Kwang W Nam, Harry E Rubash, Guoan Li, Kunihide Muraoka, Masatoshi Naito, Koichi Kinoshita, Young-Min Kwon Tomonobu Hagio, Tetsuya Sakamoto, Norihito Watanabe, So Minokawa, Tomohiko Minamikawa, Hajime Seo, Poster No. 0845 Tetsuro Ishimatsu, Sodai Ishii Development of a Large Animal Model of Local Non-Weight-Bearing to Study its Effects on Poster No. 0836 Musculoskeletal Conditions Biochemical and Histological Characterisation of Olumide O Aruwajoye, Matthew Phipps, Tracy Wassell, the Porcine Acetabular Labrum and Labral-Cartilage Harry KW Kim Junction and its Relationship to Function R achel L Pallan, Joanne Tipper, John Fisher, Poster No. 0846 Sophie Williams Analysis Of The Role Of Piriformis In Hip Joint Stability: Intraoperative Gap Measurement Using A Tensor Poster No. 0837 Isao Matsushita, Yoshiaki Ito, Hiraku Motomura, Hip Joint Contact Force In Femoroacetabular Tomoatsu Kimura Impingement Population During Walking: An Exploratory Study Poster No. 0847 Giulia Mantovani, Mario Lamontagne, Paul E Beaule Effect of Capsulotomy on Hip Stability and Range of Motion: Should Capsules be Repaired after Hip Poster No. 0838 Arthroscopy? Side to Side Asymmetry of the Proximal Femoral Suenghwan Jo, Alexander W Hooke, Kai-Nan An, Anatomy: 3D CT Analysis of 122 Hips Rafael J Sierra, Robert T Trousdale Dimitris Dimitriou, Tsung-Yuan Tsai, Kwan K Park, Kwang W Nam, Harry E Rubash, Young-Min Kwon, Poster No. 0848 Guoan Li Simultaneous Hip Head-Stem Taper Junction Measurements of Electrochemical Corrosion and Poster No. 0839 Micromotion: A Comparison of Taper Geometry Subchondral Bone Properties Of Cam-type and Stem Material Femoroacetabular Impingement Deformities Laur a Scholl, Viswanathan Swaminathan, Reginald Lee, POSTERS Ahmed Alnabelseya, Ifaz Haider, Andrew D Speirs, Lokesh K Raja, Ahmad Faizan, Mayur Thakore, Paul E Beaule, Hanspeter Frei Kevor TenHuisen

Poster No. 0840 PS1 Hip and Knee Arthroplasty - Kinematics Redefining the Acetabular Component Safe Zone for Posterior Approach Total Hip Arthroplasty Poster No. 0849 Jacob Bobman, Jonathan Danoff, Gregory Cunn, Katie Anatomically Contoured Dual Mobility Insert Mitigates Peyser, Calvin Zhu, Jeffrey Geller, William Macaulay Soft-tissue Impingement and Insert Entrapment: A Cadaver Verification Study PS1 Hip - Mechanics - Kinematics Kartik Mangudi Varadarajan, Thomas Zumbrunn, Michael Duffy, Harry Rubash, Henrik Malchau, Poster No. 0841 Andrew A Freiberg, Orhun Muratoglu A Validated Robotic System for Native Hip Biomechanical Analysis Poster No. 0850 Mary T Goldsmith, Matthew T Rasmussen, Travis Lee Gait Asymmetry in Patients with a Dual Mobility Total Turnbull, Christiano A.C. Trindade, Robert F LaPrade, Marc Hip Arthroplasty: a Randomized Clinical Trial J Philippon, Coen A Wijdicks Danilo S Catelli, Sarah Reynolds, Mario Lamontagne, Paul E Beaule

86 Poster No. 0851 Poster No. 0860 Can Simulated Activities Confirm the Need of Effects of Impaction Assembly Forces on Micromotion Anatomical Articular Surface Together with ACL and Electrochemical Performance of Taper Junctions Preservation to Restore Normal Activity Dependent David Pierre, Viswanathan Swaminathan, Laura Scholl, Knee Kinematics? Philip Williams, Kevor TenHuisen Thomas Zumbrunn, Kartik Mangudi Varadarajan, Harry E Rubash, Henrik Malchau, Guoan Li, Orhun Muratoglu Poster No. 0861 Design Features and Kinematic Behaviour of a Poster No. 0852 Customized Surface-Guided Knee Implant Effect of Tibial Posterior Slope on the Kinematic and Shabnam Pejhan, Olivia Essex, Eric Bohm, Jan-Mels Brandt, Patellofemoral Contact Force After Posterior-stabilized Urs Wyss Total Knee Arthroplasty Hideki Mizu-uchi, Ken Okazaki, Shigetoshi Okamoto, PS1 Hip and Knee Arthroplasty - Infection Satoshi Hamai, Umito Kuwashima, Koji Murakami, Yukihide Iwamoto Poster No. 0862 Epidemiology of Infecting Microorganism at First Time Poster No. 0853 Revision of Primary Hip Arthroplasty for Infection Knee Extension Limitation At Heel Strike Will Lead To Richard J Holleyman, Paul N Baker, Andre Charlett, The Increase Of Toe Out Angle During Gait In The Early Kate Gould, David J Deehan Postoperative Period After Total Knee Arthroplasty Kengo Harato, Yasuo Niki, Takeo Nagura, Yoshiaki Toyama, Poster No. 0863 Yasunori Suda Pathophysiologic Differences In TLR4 Vs. TLR2 Activation Associated With Co-alloy Implant Debris: Poster No. 0854 Implications For Implant Associated Infections Ml Stability In Early Flexion May Be More Important Lauryn Samelko, Kyron McAllister, Joshua Jacobs, Than Normal Kinematics After Tkr Nadim Hallab Philip C Noble, Shigeki Asada, Yafei Ouyang, Hugh Jones, Sabir Ismaily Poster No. 0864 C ombined Local And Systemic Antibiotic Treatment Poster No. 0855 Effective Against Peri-implant Biofilm Infection With Kinematic and Wear Performance of a Novel Cruciate Staphylococcus aureus Retaining Biomimetic Implant Manufactured from Anna S van der Horst, Ethan Ledbetter, Alexander Liu, Advanced Vitamin-E Stabilized Material Paul Weinhold, Daniel Del Gaizo, Laurence Dahners Kartik Mangudi Varadarajan, Thomas Zumbrunn, Harry E Rubash, Henrik Malchau, Guoan Li, Orhun Muratoglu Poster No. 0865 Obesity Increases Risk of Mixed vs. Single Organism Poster No. 0856 Genus Infection in Primary Knee Arthroplasty Comparison of Robotic Assisted Gait Training versus Revised for Infection Conventional Physical Therapy after Total Hip Richard J Holleyman, Paul N Baker, Andre Charlett, Replacement - a Prospective Clinical Study Kate Gould, David J Deehan Kohei Yabuno, Noriyoshi Sawada, Tadashi Kameyama, Shuichi Hamamoto, Motonori Kanazawa Poster No. 0866 Bacterial Contamination Of Diathermy Tips Poster No. 0857 Used During Orthopaedic Procedures Dynamic Hip Kinematics During Golf Swing In Patients Ali Abdulkarim, Peter Coffey, Eoin Sheehan After Total Hip Arthroplasty Daisuke Hara, Yasuharu Nakashima, Satoshi Hamai, PS1 Hip and Knee Arthroplasty - Computational Hidehiko Higaki, Satoru Ikebe, Takeshi Shimoto, Masanobu Modeling Hirata, Masayuki Kanazawa, Yusuke Kohno, Yukihide Iwamoto Poster No. 0867 ORS Best Knee Poster

F actors InfluencingTKR Joint Mechanics POSTERS Poster No. 0858 in the Varus Knee R otational Alignment Of Femorotibial Joint Before Clare K Fitzpatrick, Sherrod Woods, Paul J Rullkoetter And After Mobile-bearing TKA Yoshikazu Tsuneizumi, Tae-Hyun Lee, Tadashi Tsukeoka Poster No. 0868 E fficient Computational Framework for Population- Poster No. 0859 Based Evaluation of TKR-Implanted Joint Mechanics Assessment Of The Mechanisms Of Rim Damage In Azhar A Ali, Chadd W Clary, Lowell M Smoger, Dual Mobility Polyethylene Inserts Using Retrievals Clare K Fitzpatrick, Paul J Rullkoetter, Peter J Laz And Cadaver Models Audrey K Nebergall, Andrew A Freiberg, Meridith Greene, Poster No. 0869 Jean Langlois, Henrik Malchau, Orhun Muratoglu, T hermoelastic Stress Analysis For Surface Stress Shannon Rowell, Anders Troelsen, Thomas Zumbrunn, Imaging Predicts Clinical Outcome Of The Total Hip Kartik Mangudi Varadarajan Arthroplasty Hiroshi Wada, Hajime Mishima, HIsashi Sugaya, Tomofumi Nishino, Masashi Yamazaki, Koji Hyodo 87 Poster No. 0870 PS1 Hip and Knee Arthroplasty - Implant Wear Digital Component Size Prediction for Total Knee Arthroplasty Poster No. 0880 Takayuki Murayama, Joseph Maratt, Tomoharu Mochizuki, Cobalt Ions Result in the Release of Intracellular Toshihide Fujii, John D Blaha Calcium in Endothelial Cells and Lead to Increased Angiogenesis Poster No. 0871 Jeanette H Man, Janine Struve, Dorothee Weihrauch, Simulations Based on Various In Vivo Activities to Hsiang-En Wu, James T Ninomiya Analyze Micro-Separation in Total Hip Implants Thomas Zumbrunn, Kartik Mangudi Varadarajan, Michael Poster No. 0881 Duffy, Harry E Rubash, Henrik Malchau, Andrew A Freiberg, Quantifying Material Loss in Dual Taper Orhun Muratoglu Hip Arthroplasty Douglas Van Citters, Dylan Assael, John H Currier, Poster No. 0872 Michael B Mayor, Stephen S. Tower How Does Acetabular Component Orientation Influence Iliopsoas Impingement in THA? Poster No. 0882 In-vivo 3D Modeling Study Cell-Induced Corrosion on Titanium Alloys Kwan Kyu Park, Tsung-Yuan Tsai, Dimitris Dimitriou, Shiril Sivan, Kathleen G Pieri, Jeremy L Gilbert Harry E Rubash, Guoan Li, Young-Min Kwon Poster No. 0883 Poster No. 0873 Corrosion of Modular Acetabular Liners Precision of Low Dose CT Localization of RSA Markers Harry Hothi, Kevin Ilo, Robert Whittaker, Antti Eskelinen, Cyrus D Brodén, Henrik Olivecrona, Buster Sandgren, Jay Meswania, Shiraz Sabah, Johann Henckel, Gerald Q. Maguire Jr, Marilyn E. Noz, Michael P. Zeleznik, Gordon Blunn, John Skinner, Alister Hart Lars Weidenhielm Poster No. 0884 Poster No. 0874 Durability Of Ceramic Coatings On Metallic Implant Validation of Three Dimensional Models of the Distal Bearing Surfaces Characterized Via Quantitative Femur Created from Surgical Navigation Data Scratch Testing Pia Bücher, David A Wilson, Carl Martin Grewe, Valentin Alex Stoller, Jeff Anderson Mocanu, Stefan Zachow, Carolyn Anglin, Michael Dunbar Poster No. 0885 Poster No. 0875 The Degree of Periprosthetic Tissue Metallosis Does Morphometrical Measurement Of Resected Surface Of Not Correlate with the Degree of Tissue Necrosis Anterior Femoral Condyle For Chinese Population Patricia Campbell, Sean Borkowski, Edward Ebramzadeh, Chang-Hung Huang, Lin-I Hsu, Kun-Jhih Lin, Yung-Chang Scott D Nelson Lu, Wen-Haur Pu, Ting-Kuo Chang, Hung-Wen Wei Poster No. 0886 Poster No. 0876 Assessment of Damage on a The Effect of Unicondylar Knee Arthroplasty Dual Mobility Acetabular System Alignment on Ligament Loads is Subject Specific Chelsea Koch, Marcella Elpers, Christina Esposito, Mohammad Kia, Kevin Cassidy, Joseph Lipman, Geoffrey Geoffrey Westrich, Timothy Wright Westrich, Michael Cross, David J Mayman, Andrew D Pearle, Timothy Wright, Carl Imhauser Poster No. 0887 Metal Release in Ceramic and CoCr Heads at the Poster No. 0877 Modular Junction: a Matched Cohort Retrieval Study POSTERS A Lateralized Anterior Flange Improves Femoral Sevi B Kocagoz, Richard Underwood, Daniel MacDonald, Component Bone Coverage in Total Knee Arthroplasty Jeremy L Gilbert, Clare M Rimnac, Steven M Kurtz Shinya Kawahara, Ken Okazaki, Shigetoshi Okamoto, Umito Kuwashima, Koji Murakami, Yukihide Iwamoto, Poster No. 0888 Scott A Banks Effect of Molybdate Ion on the Fretting Corrosion of a CoCrMo - Titanium Alloy Couple Poster No. 0878 Johnny Dufils, Dmitry Royhman, Mathew Mathew, Numerical Evaluation, Experimental Validation, and Markus A Wimmer, Michel P Laurent Model-Based Human Body Scaling of RF-Related Heating For Hip Replacement Devices Under 3-T MRI Poster No. 0889 Laura Scholl, Jianfeng Zheng, Mayur Thakore, Rob Ledger, In Vivo Metal Hypersensitivity is dependent Karen Ariemma, Margaret Klippel, Ji Chen on the NALP3 Inflammasome Lauryn Samelko, Marco Caicedo, Kyron McAllister, Poster No. 0879 Joshua Jacobs, Nadim Hallab The Distance From The Skin Surface To The Extramedullary Cutting Guide Is A Practical Useful Poster No. 0890 Reference Guide For Tibial Slope In Total Knee T he Influence Of Patellofemoral Degenerative Arthroplasty Changes On The Outcome Of The Tadashi Tsukeoka, Yoshikazu Tsuneizumi, Tae-Hyun Lee Unicompartmental Knee Replacement Ali Abdulkarim, Nicola Motterlini, TM O’Donnell, MJ Neil 88 Poster No. 0891 Poster No. 0900 Differences in Head Taper Corrosion between Simulator Kinematic Inputs and Experimental Two MOM-THR Designs from a Single Manufacturer Setup Influence the Wear of Knee Replacements using the Same Femoral Stem Design Claire L Brockett, Abdellatif Abdelgaied, Tony Harry Hothi, Robert Whittaker, Jay Meswania, Paul Bills, Haythornthwaite, Cath Hardaker, John Fisher, Liam Blunt, Radu Racasan, Gordon Blunn, John Skinner, Louise M Jennings Alister Hart Poster No. 0901 Poster No. 0892 Anatomical and Ultrastructural Aspects of Surface Cross-linked Ultra High Molecular Weight Well-functioning Retrieved Total Knee Polyethylene by Diffusion of Dicumyl Peroxide Arthroplasty Specimens Sanem Kayandan, Brinda Doshi, Ebru Oral, Erik L. Woodard, Casey T Hebert, Robert Skinner III, Orhun Muratoglu William Michael Mihalko

Poster No. 0893 Poster No. 0902 Wear of Crossed-Linked UHMWPE using Evaluation of Electrochemically Treated Proteinaceous Electromechanical and Pneumatic Hip Joint Simulators Film Formation on CoCrMo Alloy for Hip Prostheses Murat Ali, Susan Partridge, Mazen Al-Hajjar, Shelley Kerwell, David Baer, Elizabeth Martin, Markus A Sophie Williams, John Fisher, Louise M Jennings Wimmer, Kenneth Shull, Mathew Mathew

Poster No. 0894 Poster No. 0903 Characterizing Large-scale Fretting-corrosion Performance of Biolox Delta Ceramic Bearings with Damage At Modular Hip Junctions: A Parametric Titanium Adapter Sleeves in Revision Hip Arthroplasty: And Mechanistic Study A Retrieval Analysis Megha Patel, Dmitry Royhman, Maria Runa, Markus A Mark Figgie Jr., Marcella Elpers, Douglas Padgett Wimmer, Joshua Jacobs, Mathew Mathew, Nadim Hallab Poster No. 0904 Poster No. 0895 Development of a Clinically Grounded Protocol for Analysis Of The Interface Ti6Al4V/MG-63 Osteoblasts Creating Standardized Femoral Head Damage for Use Under Different Applied Potentials: Simulating Hip in Hip Simulator Wear Testing Stem Environment Karen M Kruger, Nishant Tikekar, Anneliese Heiner, John J Maria Runa, Eik-lang (Jenny) Lau, Luis Rocha, Lannutti, John Callaghan, Thomas D Brown Tolou Shokuhfar, Mathew Mathew Poster No. 0905 Poster No. 0896 The Influence of Stem Taper Re-Use and Head/Stem Titanium Alloy Sleeves Do Not Prevent Fretting Taper Mismatch on the Failure Load of Ceramic Heads Corrosion in Modular THA Julian Gührs, Florian Witt, Annika Krull, Mandy Körner, Daniel W MacDonald, Galen Clarkin-Wright, Javad Parvizi, Michael M Morlock Gwo-Chin Lee, Gregg R Klein, Matthew Kraay, Clare M Rimnac, Jeremy L Gilbert, Steven M Kurtz Poster No. 0906 Mechanistic Transitions in Fretting-corrosion Poster No. 0897 Behavior of Various Metal Couples in Hip Vitamin E Grafted Highly Crosslinked Polyethylene Hip Implant Modular Junctions Acetabular Liners Exhibit Stable, Ultra Low Wear after Dmitry Royhman, Megha Patel, Maria Runa, Robin Pourzal, 85 Million-Cycles of In Vitro Wear Testing Markus A Wimmer, Nadim Hallab, Joshua Jacobs, Diego A Orozco Villasenor, Darcy Marshall, Alicia Rufner Mathew Mathew

Poster No. 0898 Poster No. 0907 Material Loss at the Head Taper Junction of Metal-on- Estimation of In Vivo Positioning of Femoral Metal Pinnacle Total Hip Replacements Head Dislocation Retrievals for Case-Specific

Harry Hothi, Robert Whittaker, Jay Meswania, Reshid Retrieval Wear Simulations POSTERS Berber, Antti Eskelinen, Gordon Blunn, John Skinner, Karen M Kruger, Anneliese Heiner, Nishant Tikekar, Alister Hart John J Lannutti, John Callaghan, Thomas D Brown

Poster No. 0899 Poster No. 0908 Different levels of Rotational and Translational Sequentially Irradiated And Annealed Polyethylene: Surgical Mal-Positioning Affects the Occurrence Analysis Of 11 Years Of Wear Simulation Results and Severity of Edge Loading and Wear in Total Hip LaQuawn Loving, Lizeth Herrera, Aaron Essner Replacements Mazen Al-Hajjar, Oscar O’Dwyer Lancaster-Jones, Sophie Poster No. 0909 Williams, Louise M Jennings, Jonathan Thompson, Graham Dynamic Mechanical Properties And Cyclic Creep H Isaac, Eileen Ingham, John Fisher Response Of Swine Cartilage In Comparison To Pva Hydrogels Orkun Kaymakci, Hatice Bodugoz-Senturk, David Bichara, Amy Moreira, Orhun Muratoglu

89 Poster No. 0910 Poster No. 0919 Wear Rates Of Highly Cross-linked Versus Conventional Does Component Alignment Affect Gait Symmetry Polyethylene Within The Same Knee Design: in Unilateral Total Hip Arthroplasty Patients? Retrieval Study Of 3 Implant Series Tsung-Yuan Tsai, Dimitris Dimitriou, Jing-Sheng Li, John H Currier, Xiaotian Wu, Daniel Santana, Joseph Cook, Kwang-Woo Nam, Guoan Li, Young-Min Kwon Barbara H. Currier, Douglas Van Citters Poster No. 0920 Poster No. 0911 Eliminating Blood Transfusion in Primary Total Hip What is the Impact of Manufacturer Component and Knee Arthroplasty: An Achievable Goal? Mixing and Matching on Taper Material Loss Joshua Holt, Benjamin Miller, John Callaghan, in Total Hip Replacements? Charles Clark, Melissa Willenborg, Nicolas Noiseux Robert K Whittaker, Harry Hothi, Jay Meswania, Kevin Ilo, Shiraz Sabah, Johann Henkel, Gordon Blunn, John Skinner, Poster No. 0921 Alister Hart Mid-term Radiological Results Of Rotational Acetabular Osteotomy In 93 Hips With More PS1 Hip and Knee Arthroplasty - Clinical Outcomes Than 5 Years’ Follow-up Research Masamitsu Tomioka, Yutaka Inaba, Naomi Kobayashi, Hiroyuki Ike, Tomoyuki Saito Poster No. 0912 The Use of Noninvasive Endothelial Dysfunction Poster No. 0922 Test for Prediction of Deep Vein Thrombosis Does Unicompartmental Knee Arthroplasty after Total Hip Arthroplasty Component Alignment Affect In-Vivo Articular Kentaro Shinohara, Naoto Mitsugi, Naoya Taki, Masato Contact at Standing Position? Aratake, Hirohiko Ota, Hiroyuki Suzuki, Kazuo Kimura, Tsung-Yuan Tsai, Andrew A Freiberg, Guoan Li, Tomoyuki Saito Young-Min Kwon

Poster No. 0913 Poster No. 0923 Short Stems Promote Positive Bone Remodeling; Positional And Chronological Change In Pelvic A DEXA And FEA Study Tilt 5 Years After Total Hip Arthroplasty ~ Ahmed Ercan, Alison Traynor, David Simpson, Jorg Jerosch A Three-dimensional Analysis Haruka Suzuki, Yutaka Inaba, Naomi Kobayashi, Yohei Poster No. 0914 Yukizawa, Takashi Ishida, Hiroyuki Ike, Masamitsu Tomioka, Percutaneous Cryoneurolysis Nerve Block for Total Tomoyuki Saito Knee Arthroplasty to Reduce Postoperative Pain and Improve Patient Outcomes Poster No. 0924 Ryan Bliss, Gabe Lensing, Miles Parsons, Justin Harris, Intraoperative Lateral Gapping Associated with Vinod Dasa Improved Subjective Pain and Function Scores 2-5 Years after TKA Poster No. 0915 Cale Jacobs, Christian Christensen Cited Causes of TKR Failure in the United States and the Associated Financial Burden Poster No. 0925 Nicholas C Marais, Eric M. Lucas, Taylor Gambon, The Implications of Surgical Approach on the John D DesJardins Location of Moderate and Severe Adverse Local Tissue Reactions Following Metal-on-Metal Hip Arthroplasty Poster No. 0916 Rami Madanat, Daniel K Hussey, Gabrielle S Donahue, Differences Between Observed and Patient-Reported Charles Bragdon, Orhun Muratoglu, Henrik Malchau POSTERS Functional Status Following Primary Total Joint Arthroplasty Poster No. 0926 Robin M Queen, A Jordan Grier, Robert J Butler, Navigated Femur First Total Hip Arthroplasty leads to Samuel S Wellman, Michael P Bolognesi, David E Attarian improved Biomechanical Outcome after surgery Tim A Weber, Sebastian Dendorfer, Sjoerd K. Bulstra, Poster No. 0917 Joachim Grifka, Gijsbertus J. Verkerke, Tobias Renkawitz S hort-Term Complications and Revision following Unicondylar Knee Arthroplasty Poster No. 0927 Kevin L Ong, Edmund Lau, Steven Kurtz, Erik Hansen, Cementless Hip Arthroplasty In The Very Elderly: Jess Lonner Does Stem Design Matter? A Radiological Study Of 607 Cases Poster No. 0918 Tim Boymans, Rachel Senden, Martijn Schotanus, 5 Year Outcome of Randomised Trial Comparing Ide Heyligers, Bernd Grimm Large Metal-metal to Standard Polyethylene Bearings In Hip Replacement Poster No. 0928 Richard J Holleyman, Jayasree Ramaskandhan, Multi-Component Rehabilitation Following Total Hip Michelle Bardgett, Russell Bowmann, Jim P Holland Arthroplasty: A Randomized Controlled Trial Douglas A Dennis, Dana L Judd, Joshua Winter, Todd M Miner, Michael R. Dayton, Jennifer E. Stevens-Lapsley, Jason M Jennings, Bradley Davidson 90 Poster No. 0929 PS1 Hip and Knee Arthroplasty - Polyethelene and Perioperative Outcomes of Total Knee Arthroplasty Biomaterials in Patients with Major Depression Sapan Shah, David Mossad, Olivia Wang, Mark H Gonzalez Poster No. 0940 Oxidation Mechanisms in Highly Cross-linked Poster No. 0930 and Conventional Gamma-inert Sterilized Improvement of Endothelial Dysfunction in Patients UHMWPE Tibial Inserts Who Have Undergone Total Knee and Hip Arthroplasty Barbara H Currier, John H Currier, Steven Reinitz, Kentaro Shinohara, Naoto Mitsugi, Naoya Taki, Masato Douglas Van Citters Aratake, Hirohiko Ota, Tomoyuki Saito Poster No. 0941 Poster No. 0931 White Band as an Indicator for Polyethylene Does Stem Design Affect Periprosthetic Bone Density: Oxidation - Fact or Artifact A Systematic Review of Clinical Outcome Studies Jacob Blitz, Kim-Phuong Le, Carlos Aponte, Nicole Lau, Ashleen Knutsen, Edward Ebramzadeh, Vorawut Ammatathongchai, Lin Song Sophia Nicole Sangiorgio Poster No. 0942 Poster No. 0932 In Vivo Oxidation in Remelted Highly Cross-linked Excessive Bone Resection Angle Outliers Following Bearings: A Clinical Concern? Conventional Total Knee Arthroplasty Techniques Steven D Reinitz, Barbara H Currier, Rayna A Levine, Can Be Improved With Intraoperative X-rays John P Collier, Douglas W Van Citters Ryutaku Kaneyama, Hidetaka Higashi, Hideaki Shiratsuchi, Kazuhiro Oinuma, Yoko Miura, Tatsuya Tamaki Poster No. 0943 Variation of Oxidation with Irradiation Dose and Poster No. 0933 Source in Highly Crosslinked Remelted UHMWPE Association between Physical Therapy Modalities Mitchell Fung, Rayna A Levine, Barbara H Currier, and Complications after Primary TKA Steven D Reinitz, Douglas W Van Citters Kevin L Ong, Paul Lotke, Edmund Lau, Michael Manley, Steven Kurtz Poster No. 0944 Surface Topography and Damage Grading of Modern Poster No. 0934 Total Hip Arthroplasty Modular Head-Neck Junctions Intraoperative Stability Test of Total Hip Arthroplasty Nguyen Q Ha, Robin Pourzal, Deborah J. Hall, Robert M Hiromasa Tanino, Tatsuya Sato, Yasuhiro Nishida, Urban, Brett R. Levine, Hannah J Lundberg Hiroshi Ito Poster No. 0945 Poster No. 0935 Peak Stress Dictates Fatigue Crack Growth in a Technique and Operator Reliability in CMM Volume Hindered Phenol Antioxidant UHMWPE Loss Measurement of Head Bores Krista Parran, Venkat Narayan, Clare M Rimnac Bridget E Shaia, Rayna A Levine, John H Currier, John Collier, Douglas Van Citters Poster No. 0946 Effect Of Impact Assembly On The Interface Poster No. 0936 Deformation And Fretting Corrosion Of Modular Hip Radiographic, MicroCT, and Mechanical Evaluation of Tapers: An In Vitro Study Implant Stability in a Percutaneous Osseointegrated Anna Panagiotidou, Timothy E Cobb, Jay Meswania, John Docking System for Above Knee Amputees Skinner, Alister Hart, Fares Haddad, Gordon Blunn Alex J Drew, Erik N Kubiak, Joseph Longo, Kent N Bachus Poster No. 0947 Poster No. 0937 Notch Fatigue of Untreated and Crosslinked UHMWPE: Clinical Analysis Of Preoperative Deep Vein A Linear Elastic Fracture Mechanics Approach Thrombosis Risk Factors In Patients Undergoing Farzana Ansari, Michael Ries, Lisa Pruitt

Total Hip Arthroplasty POSTERS Hiroki Wakabayashi, Masahiro Hasegawa, Poster No. 0948 Rui Niimi, Akihiro Sudo S hort Term and Long Term Chemical Effects of Micro-CT on UHMWPE Poster No. 0938 Steven D Reinitz, Megan N Mishra, Rayna A Levine, Relationship Between The Muscle Atrophy And Robot Barbara H Currier, Douglas W Van Citters Gait Walking In Total Hip Arthroplasty Shuichi Hamamoto, Kohei Yabuno, Tadashi Kameyama, Poster No. 0949 Noriyoshi Sawada, Motonori Kanazawa Squeaking And Microcracks In A Delta-delta Ceramic Coupling: Pin-on-disc Study Poster No. 0939 Kiyokazu Fukui, Ayumi Kaneuji, Tadami Matsumoto, C hronological Changes Of Functional Cup Kazuhiro Shintani Positioning At A Minimum Follow-up Of 7 Years After Total Hip Arthroplasty Yusuke Okanoue, Teruhiko Kawakami, Koji Aso, Natsuki Sugimura, Masahiko Ikeuchi 91 Poster No. 0950 Poster No. 0960 Reasons for Revision, Surface Damage, and In Vivo S urgeon Accuracy in Utilizing Anatomic Landmarks for Oxidation for Retrieved Sequentially Annealed HXLPE Femoral Component Positioning in TKA in Total Knee Arthroplasty Philip C Noble, Fadi Saied, Rikin Patel, Sabir Ismaily, Daniel MacDonald, Michael A Mont, William Hozack, Melvyn A. Harrington, Glenn Landon, Brian Parsley Peter Sharkey, Arthur Malkani, Steven Kurtz Poster No. 0961 Poster No. 0951 D oes Robot-Assisted Total Hip Arthroplasty Better Fretting Corrosion of Silicon Nitride against Cobalt Restore Native Hip Anteversion? Chromium and Titanium Medical Alloys Tsung-Yuan Tsai, Dimitris Dimitriou, Harry E Rubash, Maria Pettersson, Abimbola Oladokun, Michael Bryant, Guoan Li, Young-Min Kwon Håkan Engqvist, Cecilia Persson, Anne Neville Poster No. 0962 Poster No. 0952 Assessment Of Accuracy In Acetabular Cup NF-ΚB Decoy Oligodeoxynucleotide Increases Placement Using A Smartphone -cadaveric Study Bone Mineral Density in the Murine Femur during With Image Free Navigation System Continuous Infusion of Polyethylene Particles Kenji Kurosaka, Shigeo Fukunishi, Shoji Nishio, Tzu-hua Lin, Taishi Sato, Jukka Pajarinen, Changchun Fan, Tomokazu Fukui, Yuki Fujihara, Shinichi Yoshiya Florence Loi, Ruth Zhang, Zhenyu Yao, Kensuke Egashira, Stuart B Goodman PS1 Hip and Knee Arthroplasty - Osteolysis and Adverse Soft Tissue Reaction Poster No. 0953 Is There In-vivo Oxidation In Crosslinked UHMWPE? Poster No. 0963 ORS Best Hip Poster Celia E Macias Gupta, Michelle A Ross, David B Warner, Modularity of Metal-on-Metal Hip Implants Venkat S Narayan Increases Cobalt:Chromium Ratio Kevin Ilo, Karim Aboelmagd, Harry Hothi, Robert PS1 Hip and Knee Arthroplasty - Finite Element Analysis Whittaker, Asaad Asaad, Gordon Blunn, John Skinner, Alister Hart Poster No. 0954 WITHDRAWN Poster No. 0964 Utility of Metal Ion Level in Patients with Corrosion of Poster No. 0955 Dual Taper Modular THA: Sensitivity and Specificity for Development of a Subject SpecificT otal Knee Predicting “Pseudotumours” Replacement Contact Model using Finite Element Young-Min Kwon, Tsung-Yuan Tsai, William Leone, Analysis and Marker-Based Gait Analysis Guoan Li, Andrew A Freiberg, Harry E Rubash Steven P Mell, Markus A Wimmer, Hannah J Lundberg Poster No. 0965 Poster No. 0956 The Infrapatellar Fat Pad Is A Key Focal Point F inite Element Analysis of the Deformation For The Development Of Arthrofibrosis Following Behavior and Fixation Stability of Newly Total Knee Arthroplasty Monolithic Ceramic Cups Nicole G Abdul, David Dixon, Andrew Walker, David Weir, Christian Schulze, Rainer Bader Nigel Brewster, David Deehan, Derek Mann, Lee Borthwick

Poster No. 0957 Poster No. 0966 Cup Stability of Decreased Radius Metal on Metal Macrophage Cytokine Release in Response to Acetabular Cups: a Finite Element Analysis Gelsolin in the Presence of Titanium Particles POSTERS Mark Gonzalez, Farid Amirouche, Giovanni F Solitro Charlie Xie, Paramjeet Cheema, Richard Smith, William M Mihalko PS1 Hip and Knee Arthroplasty - Surgical Navigation Outcomes and Robotics Poster No. 0967 Validating a Simplified Method for Assessing Poster No. 0958 THA Taper Corrosion Susceptibility with a C ontact Force Changes After Surgical 15 year Retrieval Database Balancing Corrections In TKR Patrick Aldinger, Bob Jones, Jacob L Cartner Patrick A Meere, Tom Y.T. Lin, Christopher Bell, Svenja Schneider, Peter S Walker Poster No. 0968 Automated Segmentation of Hip Abductor Muscles in Poster No. 0959 Patients with Hip Arthroplasty to Aid Surgical Planning Active Shape Modelling Accurately Characterizes Knee Christian Klemt, Marc Modat, Johann Henckel, Manuel Cartilage Geometry in the Design of CT-based Patient- Jorge Cardoso, Alister Hart, Sebastien Ourselin SpecificC utting Guides for Knee Arthroplasty Richard P Courtis, Luke Aram, Corey Stauffer, Graham Vincent, Adam J Cyr, Michael Bowes, Lorin P Maletsky

92 Poster No. 0969 Poster No. 0978 Biological Response to Highly Cross-linked and Bone Attachment in a Series of Explanted Vitamin E-doped Polyethylene - A Wear Particle- Cementless Monobloc Cups induced Osteolysis Animal Study Michael S Kung, John Scudiero, Edward Ebramzadeh, Yung-Chang Lu, Chang-Hung Huang, Ting-Kuo Chang, Patricia Campbell Su-Ting Yeh, Yi-Ling Hsiao, Hsu-Wei Fang, Wen-Haur Pu, Chun-Hsiung Huang Poster No. 0979 Torsional Strength and Tribocorrosion PS1 Hip and Knee Arthroplasty - Implant Fixation of Modular Hip Replacement Tapers Lauren Kark, Melissa Knothe Tate, Anne Simmons Poster No. 0970 Post-implantation Intermittent PTH Enhances Poster No. 0980 Cancellous Osseointegration in a Physiologically- Broaching of the Proximal Femur in Preparation for a Loaded Murine Tibial Implant Femoral Hip Prosthesis: Congruency between Broach Xu Yang, Aleksey Dvorzhinskiy, Benjamin F. Ricciardi, and Resulting Cavity Caroline Brial, Joseph Choi, Adam L. Johnson, Suhail Dan Huff, Alex Maile, Niklas B Damm, Nicholas E Bishop, Khokhar, Robert Chojnowski, F. Patrick Ross, Marjolein C.H. Michael Morlock van der Meulen, Mathias P.G. Bostrom PS1 Shoulder and Elbow - Computational Modeling Poster No. 0971 Using 18f-fluoride Pet/ct-scans To Assess Longitudinal Poster No. 0981 Bone Metabolism Activity Around Two Different T he Contributions of Muscle Activity Imbalance and Acetabular Components After Total Hip Arthroplasty Impaired Muscle Growth to Postural and Osseous Marloes Peters, Boudewijn Brans, Emiel Beijer, Roel Wierts, Shoulder Deformity following Brachial Plexus Birth Rene ten Broeke, Chris Arts Palsy: A Computational Simulation Analysis Wei Cheng, Roger Cornwall, Dustin L Crouch, Poster No. 0972 Katherine R Saul Modification ofT i6Al4V Substrates with Well-defined Zwitterionic Polymer Brushes for Improved Surface Poster No. 0982 Mineralization Finite Element Analysis of Effects of Surgical Pingsheng Liu, David C Ayers, Jie Song Variations on Joint Stability and Contact Pressures in Total Shoulder Arthroplasty Poster No. 0973 with Severe Glenoid Retroversion Design Of A Novel Functional Hip Prosthesis William Conaway, H. Mike Kim, Hwa Bok Wee, Created Through Additive Manufacturing For Gregory S Lewis Use In A Rodent Model Of Osseointegration Adam DM Paish, Hristo N Nikolov, Ian D Welch, Poster No. 0983 David W Holdsworth Evaluation Of Humeral Head Cartilage Using Mri T1rho Mapping In Patients With Rotator CuffT ears Poster No. 0974 Hidehiko Yuge, Takamitsu Okada, Takuaki Yamamoto, The Role Of Third-body Wear In Metal-on-polyethylene Ken Okazaki, Yukihide Iwamoto Thr On Tribo-corrosion Of The Head-neck Junction Philip C Noble, Xavier Pereira, Jerry Alexander, Poster No. 0984 Sabir Ismaily, Ryan Kim Tight Medial-Knot Tying May Increase the Risk of Re-tearing after Transosseous Equivalent Repair Poster No. 0975 of Rotator CuffT endon Comparison of Cruciate Retaining and Substituting Hirotaka Sano, Masako Tokunaga, Moriyuki Noguchi, Designs for Uncemented Application Takashi Inawashiro, Taichi Irie, Hiroo Abe Michael T Lowry, Heather Rosenbaum, Peter S Walker Poster No. 0985

Poster No. 0976 The Effect Of The Humeral Tray Component Positioning POSTERS Constraint Evaluation of Constrained Posterior for Onlay Reverse Shoulder Arthroplasty Designs Stabilized and Constrained Condylar Knee Articular Julien Berhouet, Lawrence Gulotta, Daniel Choi, Surfaces During Gait Andreas Kontaxis James Wernle Poster No. 0986 Poster No. 0977 Reverse Total Shoulder Arthroplasty Can Significantly What Implant Factors Affect Bone Ingrowth in Change the Shoulder Center of Rotation Retrieved Porous Tantalum Hip Implants? David R Walker, Aimee Struk, Thomas Wright, Scott A Banks Josa A Hanzlik, Judd Day, Gregg R Klein, Harlan M Levine, Mark A Hartzband, Javad Parvizi, Matthew Kraay, Poster No. 0987 Clare M Rimnac, Steven M Kurtz The Effect of Shoulder Humeral Component Length on Bone Stresses: A Finite Element (FE) Analysis Najmeh Razfar, Jacob M Reeves, Dan Langohr, Ryan Willing, George S Athwal, James A Johnson

93 PS1 Shoulder and Elbow - Arthoplasty PS1 Shoulder and Elbow - Kinematics and Mechanics

Poster No. 0988 Poster No. 0998 The Effect Of Prosthetic Radial Head Geometry On Effect of Arthroscopic Stabilization on In-Vivo Radiocapitellar Joint Contact Area And Pressure Glenohumeral Joint Motion and Clinical Daniel R Bachman, Sutee Thaveepunsan, Sangeun Park, Outcomes in Patients with Anterior Instability James S Fitzsimmons, Kai-Nan An, Shawn W O’Driscoll Cathryn Peltz, Tim Baumer, Renato Familara, Nima Mehran, Vasilios Moutzouros, Michael Bey Poster No. 0989 Elbow Reaction Loads in a Sit-to-Stand Activity Poster No. 0999 are Quite High and are Unaffected byT otal Elbow Relationship Between Throwing Plane And Arthroplasty Shoulder Posture During The Early Cocking Daniel Choi, Mark Figgie, Joseph Lipman, Sherry Backus, Phase In Baseball Pitching Darrick Lo, Robert Hotchkiss, Timothy Wright Yohei Takagi, Hiroshi Tanaka, Takanori Oi, Hiroaki Inui, Juichi Tanaka, Katsuya Nobuhara, Shinichi Yoshiya Poster No. 0990 X-ray Based Quantification Of Implant Placement Poster No. 1000 In Shoulder Arthroplasty Effects Of Exercise Therapy For Treatment Jeff Bischoff, Lara Vigneron, Danielle Beski Of Symptomatic Full-thickness Tears Of The Supraspinatus Tendon On In Vivo Poster No. 0991 Glenohumeral Kinematics Analysis of Severely Fractured Glenoid Components: R Matthew Miller, Adam Popchak, Dharmesh Vyas, Scott Clinical Consequences of Radiation Sterilization and Tashman, James J Irrgang, Volker Musahl, Richard E Debski Crosslinking in UHMWPE Farzana Ansari, Louis G Malito, Taylor A Lee, Poster No. 1001 Stephen B Gunther, Tom R Norris, Michael Ries, Lisa Pruitt The Relationship between Critical Shoulder Angle and In-Vivo Glenohumeral Joint Motion in Healthy Poster No. 0992 and Pathologic Shoulders Effects of Deltoid Lengthening on Functional Cathryn Peltz, Anne Drake, Vasilios Moutzouros, Outcomes Following Reverse Shoulder Arthroplasty Michael Bey Vani Sabesan, Daniel J Lombardo, Danya Josserand, Andrew Schrotenboer, J Michael Wiater Poster No. 1002 Three-dimensional Kinematic Analysis Of The Poster No. 0993 Throwing Motion Focusing On Trunk Bending, Pelvic Mechanical and Wear Characterization of Rotation, And Horizontal Abduction Of The Shoulder Polycarbonate Urethane as a Viable Option Takanori Oi, Yohei Takagi, Hiroshi Tanaka, Hiroaki Inui, for Total Shoulder Replacements Katsuya Nobuhara, Shinichi Yoshiya Hannah Gramling, Amrita Srinivasan, Lisa Pruitt Poster No. 1003 Poster No. 0994 Relationship between Humeral Torsion and Career Mechanically Assisted Crevice Corrosion Damage of Pitcher in Elementary and Junior-high Schools in Total Shoulder Arthroplasty is Comparable Yasuo Itami, Teruhisa Mihata, Masashi Neo to Total Hip Arthroplasty Judd Day, Daniel MacDonald, Joseph Abboud, Poster No. 1004 Gerald R Williams, Clare M Rimnac, Matthew Kraay, Study of Wrist Extensor-Flexor Torque Ratio Reagan McCloskey, Steven M Kurtz in Isokinetic Contractions and Architecture POSTERS Change of Common Extensor Tendon in the Poster No. 0995 Lateral Elbow Tendinopathy Biomechanical Benefits of nteriorA Offsetting of Su-Ya Lee, Yi-Hsien Liu, Chien-Ju Lin, Hsiao-Feng Chieh, Humeral Head Component in Posteriorly Unstable Li-Chieh Kuo, Fong-Chin Su Total Shoulder Arthroplasty: A Cadaveric Study Gregory S Lewis, Alexander Chacon, Seth Andrews, Poster No. 1005 Evan Roush, William Conaway, Edward Cho, H. Mike Kim Effect of Radial Tuberosity Preservation on Supination and Flexion Strength following a Distal Biceps Repair Poster No. 0996 Brandon T Brown, Michael N Nakashian, Benjamin Migration of Stemless and Stemmed Humeral Williams, James Rubright, Pat Schimoler, Daniel Schmidt, Components in Total Shoulder Arthroplasty - Andrew Pic, Patrick Smolinski, Christopher C Schmidt, A Cadaveric Study Mark Carl Miller Stephen Swope, Shouchen Dun, David Warlop Poster No. 1006 Poster No. 0997 The Effect of Physical Therapy on Glenohumeral The Influence of Reverse Shoulder Arthroplasty Joint Motion, Strength, and Clinical Outcome in Implant Variables on Muscle Activation and Joint Load Patients with Rotator CuffT ears Joshua William Giles, Dan Langohr, James A Johnson, Tim Baumer, Cathryn Peltz, Veronica Mende, George Athwal Vasilios Moutzouros, Michael Bey

94 Poster No. 1007 Poster No. 1016 Effect of Scapular Dyskinesis on Supraspinatus Effect of Tamoxifen on Fatty Degeneration of Tendon Healing in a Rat Model Rotator Cuff Muscles In Chronic Rotator CuffT ear: Katherine E Reuther, Jennica J Tucker, Stephen J Thomas, An Animal Model Study Rameen P Vafa, Joshua A Gordon, Sarah M Yannascoli, Edward Cho, Yue Zhang, Charles Lang, Anne Pruznak, Adam C Caro, Andrew F Kuntz, Louis J Soslowsky Henry J Donahue, H. Mike Kim

Poster No. 1008 Poster No. 1017 Defining Loading and Moments on Joint with Primary Versus Revision Arthroscopic Rotator Cuff Crutch Ambulation: A Biomechanical Study Repair - An Analysis In 350 Consecutive Patients Ali Alhandi, Sarah Pastoriza, Francesco Travascio, Moataz Aminudin Shamsudin, Karin Peters, Imants Rubenis, Eltoukhy, Loren Latta, Shihab Asfour, Gregory Gregory Patrick H Lam, George AC Murrell

Poster No. 1009 Poster No. 1018 Articular Contact Pressures During Prosthetic The Effect of Concomitant Glenohumeral Joint Capsule Radial Head Subluxation Release During Rotator CuffR epair: A Comparative Dipit C. Sahu, James S. Fitzsimmons, Andrew R. Thoreson, Study of 195 Arthroscopic Rotator Cuff Repairs Daniel R. Bachman, Kai-Nan An, Shawn W O’Driscoll Jordan McGrath, Patrick H Lam, Martin TS Tan, George AC Murrell Poster No. 1010 Re-attachment Site Anatomy and Supinator Muscle Poster No. 1019 Fatty Infiltration Predict Supination Strength Collagen Scaffolds are a Safe Intra-articular Following Distal Biceps Repair Drug Delivery Vehicle in a Novel Rabbit Brandon T Brown, Carmen R Latona, Michael Nakashian, Model of Arthrofibrosis Rafal Z Stachowicz, Christopher C Schmidt, Justin A Walker, Timothy Ewald, Mark Morrey, Matthew Mark Carl Miller Philip Abdel, Bernard Morrey, Joaquin Sanchez-Sotelo

Poster No. 1011 Poster No. 1020 Optimizing Deltoid Efficiency with Reverse Shoulder The Secreted Aggrecanases From Synovium In Rotator Arthroplasty Using a Novel Glenosphere Geometry CuffT ear Participate In Progression Of Cartilage Christopher Patterson Roche, Matt Hamilton, Phong Diep, Degradation In The Shoulder Joint Thomas Wright, Pierre Henri Flurin, Joseph Zuckerman, Takahiro Iino, Masaya Tsujii, Toru Wakabayashi, Howard Routman Naoki Kokubu, Hirokazu Yokoyama, Takuya Nakanishi, Masahiro Hasegawa, Akihiro Sudo Poster No. 1012 A Biomechanical Analysis On The Effect Of Poster No. 1021 Glenohumeral Abduction On Supraspinatus Repair Is the Neural Control Different in Complex Shoulder Tension And Clinical Outcomes Of Abduction Pillow Instability Patients? Usage On CuffI ntegrity Following Arthroscopic Anthony Howard, Joanne Powell, David Hawkes, Omid Rotator CuffR epair Alizadehkhaiyat, Jo Gibson, Graham Kemp, Simon Frostick Jacqueline R Hawthorne, Elise M Carpenter, Patrick H Lam, George AC Murrell PS1 Hand and Wrist - Infection and Truma

PS1 Shoulder and Elbow - Disease Process Poster No. 1022 Are the New Generation of Dorsal Plates still Poster No. 1013 ORS Best Shoulder and Elbow Poster a Greater Risk than Volar Fixed Angle Plating? Are The Brains Of Patients With Complex Results of a Meta-Analysis Shoulder Instability Wired Differently? Mitchell S Fourman, Deidre L Bielicka, Robert J Goitz, Anthony Howard, Joanne Powell, David Hawkes, John R Fowler Alison Kinghorn, Jo Gibson, Omid Alizadehkhaiyat,

Graham Kemp, Simon Frostick Poster No. 1023 POSTERS Predictive Factors of Neurovascular and Tendon Poster No. 1014 Injuries Following Dog Bites to the Upper Extremity Regulation of Rotator CuffT ear Regeneration Ram K Alluri, William Pannell, Nathanael Heckmann, by P38 MAPK Signaling Michael Bauschard, Alidad Ghiassi Jeffrey M Wilde, Jeremy A Grekin, Stuart M Roche, Jonathan Gumucio, Max E Davis, Asheesh Bedi, Poster No. 1024 Christopher L Mendias Capitate-based Angles Can Better Characterize Carpometacarpal Fracture and Dislocation Poster No. 1015 Kaicheng Wu, Vishnu Potini, Virak Tan, Kang Li Influence of Bone Loss on Stability of Base Plate Components in Reverse Shoulder Arthroplasty Charles Penninger, Jeffrey Bischoff, Mehul A Dharia

95 PS1 Hand and Wrist - Mechanics PS1 Foot and Ankle - Adult

Poster No. 1025 Poster No. 1034 Role of the Interosseous Membrane in Preventing Model-Based Validation of a Graphics Processing Radial Head Displacement during Forearm Rotation Unit Algorithm to Track Foot Bone Kinematics Frederick W Werner, Ashley Anderson, Brian J Harley Using Fluoroscopy Matthew Kindig, Grant Marchelli, Joseph M Iaquinto, Poster No. 1026 Duane Storti, David Haynor, Bruce J Sangeorzan, In Vivo Thumb Carpometacarpal (CMC) William R Ledoux Motion is Highly-Complex, with Coupled Rotations and Translations Poster No. 1035 Joseph J. Crisco, Eni Halilaj, Tarpit Patel, Douglas Moore, The Effect of Normal Aging on the Biomechanical Amy L Ladd, Arnold-Peter C Weiss Properties of Rat Achilles Tendons Emily C Vafek, Eric Friedman, Aaron T Scott, Poster No. 1027 Sandeep Mannava, Kerry A Danelson A Biomechanical Comparison Of The Thumb- tip Trajectory With/Without Trapeziometacarpal Poster No. 1036 Joint Fusion: A Cadaveric Study Regeneration of Foot Fat Pad with Autologous Yusuke Kawano, Toshiyasu Nakamura, Mitsunori Tada, Adipose Tissue Derived Mesenchymal Stem Cells Yusaku Kamata, Shinjiro Sueda, Dinesh Pai, Takeo Nagura, Zijun Zhang, Reed Mitchell, Jeremy Molligan, Lew Schon Yoshiaki Toyama Poster No. 1037 Poster No. 1028 Biomechanical Evaluation of Mini-Open and Compressive Loading across the Wrist Changes the Percutaneous Achilles Repair Techniques During Morphology and Position of the Carpal Arch and Simulated Early Progressive Rehabilitation Median Nerve Thomas O Clanton, C Thomas Haytmanek, Brady T Tamara L Marquardt, Joseph N. Gabra, Zong-Ming Li Williams, David M Civitarese, Travis L Turnbull, Robert F LaPrade, Coen A Wijdicks Poster No. 1029 High Resolution Motion Analysis for Identification PS1 Foot and Ankle - Infection and Trauma of Primary Trapeziometacarpal Joint Stabilizers During Grip Motion Poster No. 1038 Christina Salas, Deana Mercer C haracterization of Syndesmotic Behavior During External Rotation Stress Test PS1 Hand and Wrist - Soft Tissue and Nerve Joshua T Bunch, Benjamin D. Westerhaus, Evan C Glidewell, Terence E McIff, Michael B Tilley Poster No. 1030 MicroRNA Profiles Of Diseased Dupuytren’S Fascia Poster No. 1039 Reveal Increased Extracellular Matrix Synthesis Via Impact of Clamp Placement on Reduction Downregulation Of Collagen Targeting MicroRNAs of the Ankle Syndesmosis Scott Riester, Emily Camilleri, Amel Dudakovic, Diren Arsoy, Joshua T Bunch, Benjamin D Westerhaus, Evan C Glidewell, Eric Lewallen, Andre van Wijnen, Sanjeev Kakar Terence E McIff, Michael B Tilley

Poster No. 1031 PS1 Foot and Ankle - Mechanics Involvement Of Bmp7/smad Signale In De-differentiated Schwann Cells During Poster No. 1040 POSTERS Peripheral Nerve Regeneration After Injury Influence of Patient and Surgical Variability on Naoki Kokubu, Masaya Tsujii, Takahiro Iino, Loading Across a Cuneiform Osteotomy Hirokazu Yokoyama, Akihiro Sudo Mehul A Dharia, Jeffrey Bischoff, James Woodburn, Scott Tefler, Amir Al-Munajjed Poster No. 1032 Bridging A 20mm Rat Sciatic Nerve Gap Using An Poster No. 1041 UndifferentiatedB one Marrow-derived Mesenchymal Cyclic Loading of Achilles Tendon Repairs Through Stem Cell-laden Conduit Containing Vessels And Forces Simulating Early Functional Rehabilitation Decellularized Allogenic Basal Lamina Heather E. Gotha, Jack Anavian, Todd A Fellars, Sarath C. Yukitoshi Kaizawa, Ryosuke Kakinoki, Ryosuke Ikeguchi, Koruprolu, Ryan R. Rich, Christopher W DiGiovanni Souichi Ohta, Takashi Noguchi, Hiroki Oda, Shuichi Matsuda Poster No. 1042 Injuries Observed in a Prospective Transition from Poster No. 1033 Traditional to Minimalist Footwear: A Protective Effect Unique Genetic Signature and Therapeutic Targets for of High Impact Transient Forces? Diabetic Carpal Tunnel Patients Matthew J Salzler, Hollie J Kirwan, Donna M Scarborough, Anne Gingery, Tai-Hua Yang, Sandra Passe, Kai-Nan An, James T Walker, Anthony J Guarino, Eric Berkson Chunfeng Zhao, Peter C. Amadio

96 Poster No. 1043 Poster No. 1052 Can Fixation Methods for First MTP Joint A Persister Population of Biofilm Remains Arthrodesis Allow Full Weight-bearing? on the Surface of TKA Materials after Bradley C Campbell, Stephen F Conti, Mark Carl Miller, Extended Antibiotic Treatment Adam Mandel, Sudhir C Belagaje, Pat Schimoler Kenneth Urish, Peter Demuth, Brian Kwan, Hani Haider, David Craft, Thomas Wood, Charles Davis PS1 Infection PS1 Trauma - Clinical Outcomes Methodologies Poster No. 1044 Elucidating The Natural History Of Staphylococcus Poster No. 1053 aureus BiofilmF ormation And Maturation During The Effect of Balanceshoes Training on the Knee The Establishment Of Chronic Implant-associated Kinematics during Athletic Tasks Associated with Osteomyelitis In A Quantitative Murine Model Anterior Cruciate Ligament Injury Kohei Nishitani, Karen de Mesy Bentley, Sheila N Bello- Satoshi Kubota, Kohei Koresawa, Kazuyoshi Gamada Irizarry, John J Varrone, Hiromu Ito, Stephen L Kates, John L Daiss, Edward M. Schwarz Poster No. 1054 Distal Femoral Fracture Fixation: Poster No. 1045 Locking Plates Vs. Retrograde Nails CERAMENT Bone Void Filler Impregnated with Anthony Howard, Alexander Wibberley, Gentamicin Increases Bone Formation and Aafreen Rahman, Nick Kanakaris, Peter Giannoudis Decreases the Rate of Detectable Infection After Debridement in a Rat Model of Osteomyelitis Poster No. 1055 Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, A Technique to Measure Intrarticular Marjolein C.H. van der Meulen, F. Patrick Ross, Displacement on CT After Fracture of the Calcaneus Mathias P.G. Bostrom, Xu Yang Saran Tantavisut, John Lawrence Marsh, Matthew D Karam, Phinit Phisitkul, Kevin Dibbern, Poster No. 1046 Yubo Gao, Brian O Westerlind Altering Polymerization Temperature of Antibiotic-Laden Cement Can Increase Poster No. 1056 Porosity and Subsequent Antibiotic Elution Radiographic Analysis of Korean Proximal Femur Jeffrey Sundblad, Jeffrey C. Flynn, Christopher Bergum, for Lateral Impingement in Pertrochanteric Nancy Jackson, David C. Markel Fracture: PFNA vs PFNA II Wonchul Shin, Sangmin Lee, Seunghun Woo, Kuentak Suh Poster No. 1047 A Novel Murine Model of Established Staphylococcal PS1 Trauma - Pathophysiology Bone Infection in the Presence of a Fracture Fixation Plate to Study Therapies Utilizing Antibiotic-laden Poster No. 1057 Spacers After Revision Surgery Degeneration of the Cervical Spine Influences Jason A Inzana, Edward M. Schwarz, Stephen L Kates, the Risk of Sustaining Dens Fractures Hani A. Awad Marcel Betsch, Sabina Blizzard, Jung U Yoo

Poster No. 1048 Poster No. 1058 IL-12 Enhances Bacterial Killing Efficacy of Testing the Utility of Engineered Anti-Collagen Macrophages against Intracellular Bacteria I Antibody to Limit the Formation of Collagen- Bingyun Li, Therwa Hamza Rich Fibrotic Deposits in a Rabbit Model of Posttraumatic Joint Stiffnes Poster No. 1049 Andrzej Steplewski, Jolanta Fertala, Jonathan Barlow, Electrical Stimulation as an Adjunct to Antibiotic Pedro Beredjiklian, Joseph Abboud, Mark Wang, Surena Treatment During Periprosthetic Joint Infection Namdari, William Arnold, James Kostas, Cheryl Hou, Scott R Nodzo, Menachem Tobias, Ross Cole, Andrzej Fertala

Lisa Hansen, Nicole Luke-Marshall, Anthony Campagnari, POSTERS Mark Ehrensberger Poster No. 1059 The Amplitude of Pulse-Synchronous Oscillations Poster No. 1050 correlates with the Level of Intramuscular Pressure Cytokine levels following surgical sepsis: Association Andreas Nilsson, Qiuxia Zhang, Jorma Styf with Tumor Necrosis Factor Gene Polymorphisms Rajeshwar N Srivastava, Kavita Baghel, Abhijit Chandra, PS1 Cancer, Tumors Jyotsna Agrawal, Aditya Bhusan Pant, Saloni Raj Poster No. 1060 ORS Best Tumors Poster Poster No. 1051 The Epigenetic Regulation Of SOX9 By Dual Rifampin and Vancomycin Delivery from 3D MiR-145 In Human Chondrosarcoma Printed Calcium Phosphate ScaffoldsI mproves Isabella Mak, Shalini Singh, Robert Turcotte, Outcomes of Implant-associated Osteomyelitis Michelle Ghert Jason A. Inzana, Ryan P. Trombetta, Edward M. Schwarz, Stephen L Kates, Hani A. Awad

97 Poster No. 1061 Poster No. 1070 RANKL Blockade Prevents And Antagonistic Pleotropy and its Effects on Angiogenic Treats Aggressive Osteosarcomas In Mice Capacity to Promote Osteosarcoma Tumor Progression Yan Chen, Rama Khokha Stephanie N Moore, Tetsuro Oba, Heather Cole, Jonathan Schoenecker Poster No. 1062 Development of New Hybrid Treatment for Poster No. 1071 Osteosarcoma Using Sustainded-release Tearubicin Identification of Circulating miRNA Conjugated Endothelial Progenitor Cells Signatures in Osteosarcoma Patients Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Koji Uotani, Tomohiro Fujiwara, Aki Yoshida, Kazuhisa Yasuhiko Tabata, Takayuki Asahara, Ryosuke Kuroda, Sugiu, Takaaki Uehara, Toshinori Omori, Yasuaki Masahiro Kurosaka Yamakawa, Ken Takeda, Toshiyuki Kunisada, Akira Kawai, Takahiro Ochiya, Toshifumi Ozaki Poster No. 1063 Netrin-, RGM- and Slit-Ligands Do Not Poster No. 1072 Increase Proliferation in Ewing’s Sarcoma Combined Effect Of Zoledronic Acid And Telomerase- or Osteosarcoma Tumor Cells specificO ncolytic Adenovirus For Human Bryan S Margulies, Connor G Policastro, Benjamin Craxton, Osteosarcoma Cells Adrienne M Parsons, Judith A Strauss, Timothy A Damron Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Shuhei Osaki, Toshinori Omori, Kazuhisa Sugiu, Tomohiro Fujiwara, Poster No. 1064 Toshiyuki Kunisada, Aki Yoshida, Yasuo Urata, Toshiyoshi Apoptosis And Anti-tumor Effect Induced By Fujiwara, Toshifumi Ozaki Mtor Inhibitor And Autophagy Inhibitor In Human Osteosarcoma Cells Poster No. 1073 Ryosuke Horie Parathyroid Hormone Confers Transient Protection Against Radiotherapy-Induced Bone Fragility Poster No. 1065 and Trabecular Loss AICAR Induces Apoptosis in Human Osteosarcoma Megan Elizabeth Oest, Kenneth A. Mann, Nicholas D Cells through AMPK-dependent Zimmerman, Nicholas Allen, Timothy Damron PGC-1κ/TFAM/Mitochondrial Pathway Masayuki Morishita, Teruya Kawamoto, Hitomi Hara, Poster No. 1074 Yasuo Onishi, Takeshi Ueha, Masaya Minoda, Etsuko A Novel Mouse Model of Enchondromatosis by Kamata, Masahiro Kurosaka, Toshihiro Akisue Cartilage Specific Expression of Mutant Idh1 Makoto Hirata, Masato Sasaki, Qingxia Wei, Shingo Sato, Poster No. 1066 Yuning J Tang, Jay Wunder, Tak Mak, Benjamin Alman CD146 IdentifiesT umor Propagating Cells In Soft Tissue and Bone Sarcoma Yuning J Tang, Qingxia Wei, David Shih, Veronique Voisin, Poster No. 1075 Makoto Hirata, Shingo Sato, Gary D Bader, Laurie Ailles, Tumor Infiltrating PD1-Positive Lymphocytes and Jay Wunder, Benjamin Alman theExpression of PD-L1 Predict Poor Prognosis of Soft Tissue Sarcomas Poster No. 1067 Jung Ryul Kim, Kyu Yun Jang Expression of PIM1 Kinase in Osteosarcoma and the Clinical Significance Poster No. 1076 Yong Feng, Yan Gao, Jackson Shen, Gregory Cote, Increased Insulin mRNA Binding Protein-3 Expression Edwin Choy, Henry Mankin, Francis Hornicek, Correlates with Vascular Enhancement of Renal Cell POSTERS Zhenfeng Duan Carcinoma by Dynamic Multidetector-CT and is Associated with Bone Metastasis Poster No. 1068 Chao Xie, Yaying Li, Qingqing Li, Yu Chen, Regis J O’Keefe, Inhibition Of Gli2 And Smo By Clinical Edward M. Schwarz, Wakenda Tyler Agents Prevents Osteosarcoma Metastasis Masahito Nagata, Takao Setoguchi, Hiroko Nagao- Poster No. 1077 Kitamoto, Shunsuke Nakamura, Satoshi Nagano, Clinicopathologic, Prognostic And In Vitro Evaluation Masahiro Yokouchi, Yasuhiro Ishidou, Setsuro Komiya To Assess The Rationale For Mtor Inhibition In Malignant Peripheral Nerve Sheath Tumors Poster No. 1069 Makoto Endo, Nokitaka Setsu, Kenichi Kohashi, Hidetaka Tumor-suppressive Microrna-let-7a Inhibits Yamamoto, Michiyuki Hakozaki, Tomoya Matsunobu, Cell Proliferation Via Targeting Of E2f2 In Yoshihiro Matsumoto, Katsumi Harimaya, Yukihide Osteosarcoma Cells Iwamoto, Yoshinao Oda Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tstsuya Iwasaki, Hiroshi Tsumura Poster No. 1078 Association Between The Micrornas Derived From Round Cell Component And Cancer Malignancy In Myxoid Liposarcoma Yutaka Nezu, Kosuke Matsuo, Akira Kawai, Tomoyuki Saito, Takahiro Ochiya 98 Poster No. 1079 PS1 Diagnostic Imaging - Tendons, Ligaments Programmed Cell Death Ligand 1 Expression in Chordoma Poster No. 1087 Yong Feng, Jackson K Shen, Yan Gao, Gregory Cote, Choy Quantitative Evaluation of Elasticity in the Edwin, Henry Mankin, Francis Hornicek, Zhenfeng Duan Posteroinferior Shoulder Joint Capsules of Collegiate Baseball Players Using Shear-Wave Ultrasound Poster No. 1080 Elastography Stromal Cell Proliferation And Recurrence Tetsuya Takenaga, Hideyuki Goto, Katsumasa Sugimoto, Of Giant Cell Tumor Of Bone Following Masahiro Nozaki, Masahito Yoshida, Atsunori Murase, Neoadjuvant Denosumab Treatment Hiroto Mitsui, Masaaki Kobayashi, Yuko Nagaya, Isabella Mak, Nathan Evaniew, Snezana Popovic, Hirotaka Iguchi, Takanobu Otsuka Michelle Ghert Poster No. 1088 Poster No. 1081 Ultrasound Based Tendon Micromorphology Predicts A Grooved Hydroxyapatite Coated Ingrowth Collar Mechanical Characteristics of Degenerated Tendons Reduces Aseptic Loosening of Cemented Distal Yu-Jen Chang, Gregory R Bashford, Kornelia Kulig Femoral Massive Bone Tumour Prostheses: A Radiographic Pair Matched Study Poster No. 1089 Melanie J Coathup, Anish P Sanghrajka, William J Aston, The Effect of Freeze-Thawing on Magnetic Panagiotis D Gikas, Robin C Pollock, Stephen R Cannon, Resonance Imaging T2* of Freshly Harvested John A Skinner, Tim WR Briggs, Gordon W Blunn Bovine Patellar Tendon Sarah L. Pownder, Parina H. Shah, Hollis G. Potter, Poster No. 1082 Matthew F Koff Distinct Clinicopathologic Features Of Nab2-stat6 Fusion Gene Variants In Solitary Fibrous Tumor PS1 Diagnostic Imaging - Biomarkers With Emphasis On The Acquisition Of Highly Malignant Potential Poster No. 1090 Keisuke Akaike, Aiko Kurisaki-Arakawa, Kieko Hara, 18F-NaF Pet-CT Is A Good Early Clinical Marker Yoshiyuki Suehara, Tatsuya Takagi, Kazuo Kaneko, For High Bone Stress In The Lower Lumbar Spine Takashi Yao, Tsuyoshi Saito Justin Fernandez, Shasha Yeung, Andi Liu, Amanjeet Toor, Ju Zhang, Vickie Shim, Thor Besier, Jacob Munro, Peter Poster No. 1083 Robertson, Gerard Deib Does Simulating Activities of Daily Living Improve Fracture Prediction for Patients with Metastatic Poster No. 1091 Femoral Lesions? Heterogeneity in the Mechanical Response of Jacklyn Goodheart, Timothy Damron, Ara Nazarian, Differentiating Adipose-Derived Stem Cells Brian Snyder, Kenneth A. Mann Nicholas R Labriola, Eric M Darling

Poster No. 1084 Poster No. 1092 Targeting Skeletal Metastases Using HPMA Distribution Of Podoplanin In Synovial Tissues Copolymer Nanoparticle Delivery and Retention Of Rheumatoid Arthritis And Osteoarthritis Alexander B Christ, Chloe Horowitz, Yen H Chen, Yuya Takakubo, Hiroharu Oki, Tomoyuki Hirayama, Dong Wang, Ed Purdue, Steven Goldring, John H Healey Yasunobu Tamaki, Yasushi Naganuma, Suran Yang, Akiko Sasaki, Kan Sasaki, Michiaki Takagi Poster No. 1085 The Combined Effect Of Tumor-specific Oncolytic PS1 Diagnostic Imaging - Bone Adenovirus And Radiation On Bone And Soft Tissue Sarcoma Cells Poster No. 1093 Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Mineral Density Of Subchondral Bone May Be Hiroshi Tazawa, Shuhei Osaki, Tsuyoshi Sasaki, Kazuhisa Quantitatively Evaluated Using A Clinical Cone Beam

Sugiu, Aki Yoshida, Toshiyuki Kunisada, Yasuo Urata, Computed Tomography Scanner POSTERS Toshiyoshi Fujiwara, Toshifumi Ozaki Mikael J Turunen, Juha Töyräs, Harri Kokkonen, Jukka S Jurvelin Poster No. 1086 YM155, A Novel Small Molecule Survivin Poster No. 1094 Suppressant, Reduces Tumor Progression of Increased Posterior Tibial Slope Is a Risk Factor for Human Musculoskeletal Malignancies Anterior Cruciate Ligament Injuries: A Quantitative Masaya Minoda, Teruya Kawamoto, Toshihiro Akisue, Three Dimensional Study Hitomi Hara, Yasuo Onishi, Masayuki Morishita, Takayuki Murayama, Takashi Sato, Hiroshi Yamagiwa, Etsuko Kamata, Masahiro Kurosaka Satoshi Watanabe, Osamu Tanifuji, Tomoharu Mochizuki, Go Omori, Yoshio Koga, John D Blaha, Naoto Endo

99 Poster No. 1095 Poster No. 1105 Evaluation of Bone Mineral Density of the Necrotic Contrast-enhanced Computed Tomography Area in Osteonecrosis of the Femoral Head Using Distinguishes Osteoarthritic Disease State in an Equine Quantitative Computed Tomography Patellofemoral Joint So Kubota, Yutaka Inaba, Naomi Kobayashi, Hiroyuki Ike, Rachel C Stewart, Brad Nelson, Chris Kawcak, Brian Snyder, Taro Tezuka, Masaki Kawamura, Tomoyuki Saito Laurie R Goodrich, Mark Grinstaff

Poster No. 1096 Poster No. 1106 Dual Ultrasound Can Measure Kinematic Motion and Evaluation of the Acetabular Labrum in Patients Intervertebral Disc Deformation of Cervical Spine with Acetabular Dysplasia Using T2 Mapping with Mingxin Zheng, Aidin Masoudi, Sagar Umale, Daniel Arthroscopic Verification Buckland, Narayan Yoganandan, Brian Stemper, Thomas Tomonobu Hagio, Masatoshi Naito, Yoshinari Nakamura, Szabo, Brian Snyder Koichi Kinoshita, Tetsuya Sakamoto, Kunihide Muraoka, Norihito Watanabe, So Minokawa, Tomohiko Minamikawa, Poster No. 1097 Hajime Seo, Tetsuro Ishimatsu Visualization of Experimental Bone Defects by Computed Tomography at Reduced Radiation Doses Poster No. 1107 Jamie J Alexander, Zbigniew Gugala, Ronald Lindsey, John Predicting Early Osteoarthritis in the Human A. Hipp, Nathan K. Priddy, Jay S. Croley Knee: Pattern Recognition and Machine Learning Classification of Magnetic Resonance Images Poster No. 1098 Beth G. Ashinsky, Mustapha Bouhrara, Kenneth L. Urish, WITHDRAWN Christopher E. Coletta, Ilya G. Goldberg, Richard G. Spencer

Poster No. 1099 Poster No. 1108 Quantitative Analysis of Bone Texture Using Determining the Composition of Human Meniscus Digital Tomosynthesis in Spontaneous using Near Infrared Spectroscopy Osteonecrosis of the Knee (SONK) Isaac O Afara, Juuso T Honkanen, Elvis K Danso, Rami K. Yener N Yeni, Omaima Bokhari, Daniel Oravec, Woong Kim, Korhonen, Jukka S Jurvelin, Juha Töyräs Michael J Flynn, Catherine Lumley, Fred Nelson Poster No. 1109 Poster No. 1100 Cartilage MR T1ρ And T2 Quantifications: Longitudinal Analysis Of Postoperative Intertrochanteric Fracture Reproducibility And Variations Using Different Coils Based On 3d-mpr Images Of The Cortical Bone Contact And Scanners At Single And Multi-sites Site In The Fractured Area Xiaojuan Li, Valentina Pedoia, Deepak Kumar, Drew Tomohiro Yasuda Lansdown, Cory Wyatt, Julien Rivorie, Narihiro Okazaki, Dragana Savic, Matthew F Koff, Joel Felmlee, Steven PS1 Diagnostic Imaging - Cartilage (Articular and Williams, Sharmila Majumdar Meniscal) Poster No. 1110 Poster No. 1101 Effects of Articular Cartilage Constituents on Posterolateral Tibia Cartilage Condition, Age and Phosphotungstic Acid Enhanced Micro-CT Imaging Gender as Predictors of Patient-Reported Outcomes Sakari Karhula, Mikko Finnilä, Sami Kauppinen, Heikki J at 1 Year Following ACL Reconstruction Nieminen, Simo Saarakkala Brian C Lau, Favian Su, Richard Souza, Christina R Allen, Brian T Feeley, Xiaojuan Li, C Benjamin Ma Poster No. 1111 Quantification of Glycosaminoglycans (GAG) POSTERS Poster No. 1102 Concentration in Articular Cartilage by micro Functional Imaging of Biomechanics and Relaxivity Computed Tomography (μCT) Following Articular Cartilage Injury In Vitro Daniel J Mittelstaedt, David J Kahn, Yang Xia Kateri Gilliland, Logan Worke, Nancy Emery, Corey Neu Poster No. 1112 Poster No. 1103 True Four Dimensional Imaging Technology With Contrast-Enhanced Computed Tomography Correlates Advanced Tissue Geometry Fusion Methods For with the Equilibrium Modulus of Tibial Plateau Musculoskeletal Diagnosis Cartilage in a Destabilized Medial Meniscus Mouse George Papaioannou, Christos Mitrogiannis Model of Osteoarthritis Benjamin Lakin, Joshua Shelofsky, Michele Sidler, Poster No. 1113 Gisela Kuhn, Daniel Ellis, Brian Snyder, Kathryn S Stok, MRI Detection of Early Lesions of Surgically-induced Mark Grinstaff Osteochondrosis in Goats Ferenc Toth, Mikko J. Nissi, Luning Wang, Jutta M Poster No. 1104 Ellermann, Cathy S Carlson Use of the Human Metacarpophalangeal Joint as an Ideal Model of a Discreet Synovial Joint that Develops OA and is Appropriate for High Resolution Imaging, Mechanical Testing and Biochemical Analysis Benjamin Lakin, Joshua Shelofsky, Daniel Ellis, Mark 100 Grinstaff, Brian Snyder PS1 Diagnostic Imaging - Muscle, Nerve, Vasculature PS1 Policies/Guidelines/Leadership

Poster No. 1114 Poster No. 1123 Automating the Diagnosis of Peripheral Nerve Injury R evisions to Federal Guidelines for Human via Second Harmonic Generation Imaging Experimentation and the Public Response Surabhi Vijayaraghavan, Nikki M Verberne, Asad Ashraf, Jennifer Racine, Roy Aaron Michael R Hausman Poster No. 1124 Poster No. 1115 The Role of Chairman and Research Director in Changes In Central Nervous System Activity After InfluencingS cholarly Productivity and Research Peripheral Nerve Injury: A Functional MRI Study Funding in Academic Orthopaedic Surgery Tetsuro Yamasaki, Kazuya Ikoma, Ryo Oda, Masateru Alexandra Stavrakis, Ankur Patel, Zachary Burke, Amanda Nagae, Takumi Ikeda, Yasuo Mikami, Hiroyoshi Fujiwara, Loftin, Erik Dworsky, Mauricio Silva, Anthony Scaduto, Toshikazu Kubo Nicholas Bernthal

Poster No. 1116 Change In ADC and FA Values of the Normal Lumbar POSTER SESSION 2 Spinal Root as a Function of Distance From the Junction of the Dura Mater Ryo Miyagi, Toshinori Sakai, Eiko Yamabe, Hiroshi Yoshioka Posters Will Be Displayed Monday And Tuesday PS1 Diagnostic Imaging - Novel and Functional Imaging, Artifacts PS2 Biomaterials - Other

Poster No. 1117 ORS Best Hand and Wrist Poster Poster No. 1125 Multidimensional Ultrasound Imaging of the Wrist: In Vivo Safety Testing Of A Fully Reacted, Changes of Shape and Displacement of the Median Injectable Platform Hydrogel For Use In Nerve and Tendons in Carpal Tunnel Syndrome Musculoskeletal Regeneration Anika Filius, Peter C. Amadio, Marjan Scheltens, Hans Abbey A Thorpe, Christine Freeman, Paula Farthing, Paul G. Bosch, Pieter A. van Doorn, Henk J. Stam, Steven E.R. Hatton, Ian Brook, Chris Sammon, Christine L Le Maitre Hovius, Ruud W. Selles Poster No. 1126 Poster No. 1118 Customized Platelet-Rich Plasma to Promote Skeletal Quantitating the Effect of Prosthesis Design on Muscle Healing while Reducing Fibrosis Femoral Remodeling Using High-Resolution Region- Hongshuai Li, Justin Hicks, Nick Oyster, MaCalus V Hogan, Free Densitometric Analysis (DXA-RFA) Johnny Huard Richard M Morris, Jeannette O Penny, Lang Yang, Miguel A Martin-Fernandez, Jose M Pozo, Soren Overgaard, Poster No. 1127 Alejandro Frangi, J Mark Wilkinson Effects Of High Molecular Weight Hyaluronan For Joint Capsule In An Immobilized Rat Knee Model Poster No. 1119 Kenji Kanazawa, Yoshihiro Hagiwara, Masahiro Tsuchiya, A New MRI-Based 3D Bone-marrow Yutaka Yabe, Kazuaki Sonofuchi, Masashi Koide, Akira Model for In Vivo Spine Kinematics Ando, Yoshihumi Saijo, Eiji itoi Sayuri Kitahata, Kresten Rickers, Alejandro A Espinoza Orias, Steffen Ringgaard, Gunnar BJ Andersson, Cody E Poster No. 1128 Bünger, Jenna Peterson, Bruce Robie, Nozomu Inoue Oxygen Delivery from Hyperbarically Loaded Biomaterials Enhances Cell Survival Under Anoxia Poster No. 1120 Colin A Cook, Kathryn Hahn, Garret Ma, Justin Morrissette- A Novel Approach to Determine Accuracy of McAlmon, Joshua Temple, Warren L Grayson Radiographic Measurements Utilizing Three-

Dimensional Hip Implant Models Poster No. 1129 POSTERS Chris Nocera, Paul Lichstein, Thies Wuestemann, Adam Epigenetic Reprogramming Through the Manipulation Bastian, Javad Parvizi, Richard Rothman of Hydrogen Stiffness Shih Jye Tan, Josephine Yen Fang, Zhi Yang, Marcel Nimni, Poster No. 1121 Bo Han Rapid Throughput, Seamless Imaging of Human Hip Joint Tissue Across Length Scales to Elucidate Poster No. 1130 Emergent Structure-Function Relationships Where Are Our Stem Cells? Facts And Fate Of Ulf Knothe, Dirk Zeidler, Anna-Lena Keller, Autologous Stem Cells From Adipose Tissue Or Melissa Knothe Tate Medullary Blood For Orthopaedic Use Riccardo Ferracini, Raimondo Piana, Marco Busso, Poster No. 1122 Alessandro Masse’ Measuring Internal Deformation of the In Vivo Rat Spinal Cord During Traumatic Spinal Cord Injury Tim Bhatnagar, Jie Liu, Andrew Yung, Peter Cripton, Piotr Kozlowski, Wolfram Tetzlaff, Thomas Oxland 101 Poster No. 1131 Poster No. 1141 Canine Infra-patellar and Subcutaneous Adipose Chondrogenic Regeneration Using Bone Marrow Tissue Derived Multipotent Stromal Cells have Similar Clots And A Porous Polycaprolactone-hydroxyapatite In Vitro Behavior Before and After Cryopreservation Scaffold By 3d Printing Wei Duan, Nan Zhang, Mandi J Lopez Qingqiang yao, Chenshuang Li, Nancy Liu, Zorica Buser, Xinli Zhang, Liming Wang Poster No. 1132 Importance of Structural Alignment in Myogenic Cell Poster No. 1142 Delivery for Regeneration of Skeletal Muscle Proteoglycan and Cellularity Declined with Storage Michael J McClure, David J Cohen, Yen C Huang, MoonHae Time in Human Osteochondral Allograft Cartilage Sunwoo, Barbara D Boyan, Zvi Schwartz being Refrigerated for Over 25 Days But Proteoglycan Levels were Maintained in a Normal Range Poster No. 1133 Lei Ding, Keewoong Jang, Biagio Zampogna, Sebastiano Continuous Expansion Culture Enhances Vasta, Francesca De Caro, Annunziato Amendola, The Phenotype Of Nucleus Pulposus James A Martin Cells In Monolayer Culture Julien Tremblay Gravel, Derek H Rosenzweig, Poster No. 1143 Lisbet Haglund rAAV-based Genetic Modification Of Human Bone Marrow Aspirates Seeded In 3d Woven Poster No. 1134 Poly(epsilon-caprolactone) (PCL) Scaffolds The Effect Of ModifiedH yaluronan Hydrogel On The Janina Frisch, Ana Rey-Rico, Jagadeesh K Venkatesan, Prevention Of Epidural Fibrosis - In Vitro Cell Culture Frank Moutos, Gertrud Schmitt, Farshid Guilak, And Rat Laminectomy Model Henning Madry, Magali Cucchiarini Ming-Hsiao Hu, Shu-Hua Yang, Ching-Hsiao Yu, Yuan-Hui Sun, Feng-Huei Lin Poster No. 1144 Effects of ECM Removal on Decellularization Poster No. 1135 of Articular Cartilage Non-Injected Illicit Drug Use and Infectious Catherine Bautista, Hee Jun Park, Matthew Akelman, Disease Risk of Donor Tissue: Bahar Bilgen A Single Institution Retrospective Review Mark D Barton, Amir H. Qureshi, Anita Vijapura, Poster No. 1145 Loren Latta, H. Thomas Temple In Vivo Chondrogenesis Using Chondrogenic Induced Human Bone Marrow Stromal Cells (BMSCs) Mixed PS2 Biomaterials - Cartilage With a Novel Ultra-purified Alginate Gel; a Report Of Preliminary Study Poster No. 1136 Sameh Elmorsy, Tadanao Funakoshi, Norimasa Iwasaki Benefits Of Biomedical Versus Nonbiomedical Grade Alginates For The Durable And Safe Modification Of Poster No. 1146 hMSC Via rAAV-mediated Gene Transfer Coupled Finite Element Model-artificial Neural Christian Hunneshagen, Ana Rey Rico, Henning Madry, Networks Can Predict Mechanical Properties Of Magali Cucchiarini Articular Cartilage Vahid Arbabi, Behdad Pouran, Harrie Weinans, Poster No. 1137 Amir Abbas Zadpoor Effects of Freezing on the Depth-dependent Stiffness of rticularA Cartilage Poster No. 1147 David Kahn, Daniel Mittelstaedt, Clifford Les, Yang Xia The Combined Effects Of Cyclic Hydrostatic Pressure POSTERS And Continuous Passive Motion On Osteochondral Poster No. 1138 Regeneration Using Autologous Endothelial Layered Alginate Constructs: Platform Development Progenitor Cells In Rabbit Model for Co-cultures of Heterogenous Cell Populations Hsueh Chun Wang, Tzu-Hsiang Lin, Nai-Jen Chang, Meng- Poonam Sharma, Michelle Patkin, Adam H Hsieh Chian Wu, Da Jun Lin, Shu Wei Wu, Horng-Chaung Hsu, Ming-Long Yen Poster No. 1139 Characterization of Biodegradable Castor Oil Based PS2 Biomaterials - Bone Polyurethane of Different Chemical Compositions: Comparison of Solid and Porous Samples Poster No. 1148 Yasaman Ganji, Mehran Kasra Keratin Hydrogel Delivery of rhBMP-2 Promotes Healing of a Critical-Size Femur Defect in an Poster No. 1140 Osteopenic Rodent Model Bioprinting De Novo Cartilage with ECM-based Bioink Lindsey P Rau, Seth Tomblyn, Luke R Burnett Matti Kesti, Daniel Grande, Marcy Zenobi-Wong

102 Poster No. 1149 Poster No. 1160 Effects Of Myo9b Knockout On Skeletal Capillary Formation Through The Bone Substitute Is Growth And Quality A Key Factor Of Rapid New Bone Formation And Bone Yonghoon Jeong, Brooke K McMichael, Seth Nye, Seung E Remodeling In Unidirectional Porous Hydroxyapatite Yu, Ryan Sedlar, Choongsoo Shin, Martin Bähler, Beth Lee, Takeshi Makihara, Masataka Sakane, Hiroshi Noguchi, Do-Gyoon Kim Kenta Uemura, Toshinori Tsukanishi, Masashi Yamazaki

Poster No. 1150 Poster No. 1161 Effects of Microporosity and Local rhBMP-2 Nucleation and Growth of Bone-Like Hydroxyapatite Administration on Bioresorption of Beta-tricalcium via Controlled Conformational Changes in Highly Phosphate and New Bone Formation Phosphorylated Proteins Atsuhito Kakuta Melika Sarem, Steffen Lüdeke, Ralf Thomann, V. Prasad Shastri Poster No. 1151 A Novel Fixative Needle Carried Mg Can Promote Poster No. 1162 Fracture Healing In Ovx Rats A Carboxy-Methyl Cellulose Carrier Reduces Bone Zhang Yifeng Formation within a Silicate-Substituted Calcium Phosphate Scaffold Poster No. 1152 Melanie J Coathup, Charlie R Campion, Gordon W Blunn Covalently Immobilized Nacre Proteins Induce Osteogenesis in Mesenchymal Stem Cells and Poster No. 1163 Osteoblasts Bioactive Glass Ionic Dissolution Products Increase Kristopher White, Ronke Olabisi Human Osteoblast and hMSC Proliferation and Osteogenic Expression in vitro Poster No. 1153 Annie Reza, Stephen McIlhenny Critical Parameters For Drug Delivery Implant Materials In Bone Regeneration Poster No. 1164 Patricia Diaz-Rodriguez, Mariana Landin Biodegradation Of Phosphopullulan-cement For Bone Regeneration In Vitro And In Vivo Poster No. 1154 Aki Yoshida, Kentaro Yamane, Yohei Kagawa, Eri Sakaguchi, Distribution and Retention of Self-Assembling Peptide Mariko Nakamura, Yasuhiro Yoshida, Akihiro Matsukawa, Hydrogel in the Femoral Head Epiphysis Following Toshifumi Ozaki Local Intra-Osseous Infusion Matthew Phipps, Harry KW Kim Poster No. 1165 Covalent Linking Of Growth Factors To Nanocomposite Poster No. 1155 Scaffolds AndT heir Effect On Bone Formation Additive Manufactured Prevascularized Tissue Declan M Devine, Jessica S Hayes, Eilish Hoctor, Sean Engineering Constructs Gaynard, Dimitra Kotsougiani, Clement L Higginbotham, Yaser Shanjani, Yunqing Kang, Yunzhi Peter Yang Christopher H Evans

Poster No. 1156 Poster No. 1166 Using Tissue Engineering To Develop An In Vitro 3D Development of a Composite PolyD,L-lactic acid / Bone Model Calcium Phosphate Electrospun Fibrous Scaffold Gifty Tetteh, Ihtesham U. Rehman, Gwendolen C. Reilly for Bone Tissue Regeneration Marie-Noelle Labour, Marie Cavaignac, Eamonn deBarra, Poster No. 1157 David Hoey Novel Macroporous Calcium Phosphate ScaffoldT o Improve Cell Infiltration and Osseous Integration Poster No. 1167 Siddhesh R Angle, Michael R Strunk Coaxial Polycaprolactone/Polyvinyl Alcohol Electrospun NanofibersE nhance Implant

Poster No. 1158 Osseointegration in a Rat Tibial Pin Model POSTERS Developing Aligned 3D Fibrous Networks from Praveen Kanneganti, Christopher Bergum, Weiping Ren, Phenylalanine and Its Composite Nanofibers for David Markel Orthopaedic Applications Bingyun Li, Xianfeng Wang Poster No. 1168 Fabrication of 3d Printed β-tcp/pcl ScaffoldF or Bone Poster No. 1159 Tissue Engineering Does Silicon Substitution Encourage Earlier Bone Su A Park, Ji Sun Park, Jun Hee Lee, Jung Woog Shin, Formation By Hydroxyapatite Or TCP? Wandoo Kim Sorousheh Samizadeh, Melanie J Coathup, Karin Hing, Gordon Blunn Poster No. 1169 Effect Of Salidroside On Healing Of A Critical Size Segmental Bone Defect Stefan Zwingenberger, Jennifer Frehe, Angela Jacobi, Corina Vater, Eik Niederlohmann, Robert Langanke, Stefan Rammelt, Michael Gelinsky, Klaus-Peter Günther, Stuart B Goodman, Maik Stiehler 103 Poster No. 1170 Poster No. 1180 Novel Multifunctional Ester Crosslinked Acrylate Based Time Course of Peri-Implant Bone Regeneration Hydrogel As Bone Graft Material Around Loaded and Unloaded Implants in a Giacomo Tommasi, Stefano Perni, Polina Prokopovich Rat Model: A Pilot Study Shailly H Jariwala, Hwa Bok Wee, Evan Roush, Poster No. 1171 Tiffany Whitcomb, Christopher Murter, April Armstrong, Influence Of Chemistry On The In Vivo Resorption And Gregory Lewis Bone Formation Of Calcium Phosphate Ceramics. Marianne Koolen, Davide Barbieri, Cumhur Öner, Joost de Poster No. 1181 Bruijn, Harrie Weinans, Huipin Yuan Preserving Vascular Pathways while Structurally Augmenting Femoral Neck Fractures Poster No. 1172 in Osteopenic Femurs Bioactive Glass Granules And Morselized Cancellous Marc C Jacofsky, Timothy Browne, Jerry Chang, Bone Allograft In Load Bearing Defects; Colleen Hartwell, Siddhesh R Angle, Thomas A Russell A Mechanical Study Dennis Hulsen, Jan Geurts, Bert Rietbergen, Chris Arts PS2 Biomaterials - Tendon and Ligament

Poster No. 1173 Poster No. 1182 A Novel Biologic Composite for Use in Orthopaedic Development Of A New Animal Model Surgery: A Viable Alternative to Bone Cement Of Overuse Tendinopathy Amir H. Qureshi, Mark D Barton, David Kaimrajh, Ting Yuan, G Zhao, Jianying Zhang, James H-C. Wang Edward Milne, Loren Latta, H. Thomas Temple Poster No. 1183 Poster No. 1174 Chronic Tear and Rotator Cuff Repair in a Rat Model Tissue Mineral Density Dependent Mechanical Christopher Chen, Fuxin Wei, Zachary Shirley, William Properties of Individual Trabecular Plates and Rods Shelton, Michael Khazzam Do Not Differ in Anatomic Directions but Individual Trabecular Directions Poster No. 1184 Y. Eric Yu, Ji Wang, Bin Zhou, Zhengdong Zhang, Development of a Controlled Drug Delivery System X. Edward Guo in Anterior Cruciate Ligament Reconstruction with mPEG/PLGA Hydrogel Coating on Tendon Graft Poster No. 1175 Wai Yin Vivien Chiu, Sai Chuen Fu, Shu Hang Yung, Wei Assessment of Cortical Mechanical Properties Under Chuan Chen, Hsia Wei Liu, Chih Hwa Chen, Kai Ming Chan Physiological Strain Rates Reveals Favorable Collagen and Mineral Characteristics Following Bisphosphonate Poster No. 1185 Treatment Evaluation Of A PLLA Device In-vitro And In An Ovine Elizabeth Zimmermann, Bernd Gludovatz, Eric Schaible, Model Of Acute Rupture Of The Rotator Cuff Michael Hahn, Klaus Pueschel, Michael Amling, Robert William R Walsh, Nicky Bertollo, Phillip Heuberer, Ritchie, Björn Busse Chris Christou, Robert Stanton, Robert Poggie

Poster No. 1176 Poster No. 1186 Assessing Fatigue Resistance of Human Cortical Bone Material Properties of the Ovine Stifle Cruciate with 1H NMR Measurements and Collateral Ligaments Mathilde Granke, Kuniko Hunter, Sasidhar Uppuganti, Rajshree Mootanah, Nicolas Berchet, Franziska Reisse, Akhmal Hakim Zainal Ariffin, Mark D Does, Jeffry S Nyman Diagarajen Carpanen, Howard Hillstrom POSTERS Poster No. 1177 PS2 Cartilage, Synovium and Osteoarthritis - Cell and The Effect of Overall Limb Alignment on Tibial Bone Molecular Imaging Properties at Mechanical and Anatomic Orientations Robert Davignon, Paul Rochette, Michael Ferko, Stuart Poster No. 1187 Axelson F ourier Transform Infrared (FTIR) microspectroscopy of Human Articular Cartilage With Different Grades of Poster No. 1178 Osteoarthritis Characteristics of Human Mandibular Joonas Oinas, Mikko Finnilä, Sami Kauppinen, Maarit Condyle Bone Tissue Valkealahti, Petri Lehenkari, Simo Saarakkala Yonghoon Jeong, Amanda Agnew, Robert Nichol, David W McComb, Heungsoo Shin, William M Johnston, Poster No. 1188 Do-Gyoon Kim Calcium Signaling Of In Situ Chondrocytes During The Stress-relaxation Of Cartilage Explant Poster No. 1179 Mengxi Lv, Jie Ma, Michael Schenk, Lea Fang, Liyun Wang, The Effect of Frictional Conditions at the Bearing X. Lucas Lu Surface on Relative Motion of the Head-Neck Taper Junction in THR Philip C Noble, Jesal Parekh, Jonathan E Gold

104 Poster No. 1189 Poster No. 1198 Characterization Of Zinc And Calcium Spatial Quantitative MRI-T2 Mapping of Articular Cartilage Distribution At The Fibrocartilage Of Rabbit Patella- following Anatomic Anterior Cruciate Ligament patellar Tendon Complex: A Synchrotron Radiation Reconstruction: Relationship to Patient Reported Micro X-ray Fluorescence Study Measures of Symptoms, Activity, and Participation Lu Hongbin, Chen Can, Hu Jianzhong, Zheng Yi Rajan Manmohan, Nikhil Kurapati, Eric Thorhauer, Freddie H. Fu, Scott Tashman, James J Irrgang Poster No. 1190 N-acetyl Cysteine Protect Cell from Chondrocyte Poster No. 1199 Death Induced by Local Anesthetics The Effect of Inhibitors of Brd4 and CDK9 on Early Hyung Bin Park, Ra Jeong Kim, Jae-Ran Kang, Phase of Post Traumatic Osteoarthritis Young-Sool Hah Tomoaki Fukui, Jasper Yik, Dominik R Haudenschild

Poster No. 1191 Poster No. 1200 Serum Pentosidine AffectsT he Size Of Osteophyte In Intraarticular Administration of N-Acetylcysteine Knee Osteoarthritis: Ultrasonographic Evaluation and Glycyrrhizin Alleviates Acute Oxidative Stress In A Japanese Population Following Intraarticular Fracture Daisuke Chiba, Eiichi Tsuda, Yuji Yamamoto, Shugo Maeda, Mitchell C Coleman, James A Martin, Douglas C Fredericks, Eiji Sasaki, Ippei Takahashi, Shigeyuki Nakaji, Yasuyuki Mary S Bergh, Jessica E Goetz Ishibashi Poster No. 1201 PS2 Cartilage, Synovium and Osteosrthritis - Post The Role Of FoxA Factors In The Onset And Traumatic OA Development Of Osteoarthritis Andreia M Ionescu, Lin Xu, Elena Kozhemyakina, Yefu Li, Poster No. 1192 Klaus Kaestner, Vicki Rosen, Andrew Lassar Detailed Quantification of Early Articular Cartilage Structural Changes in the Murine Destabilized Medial Poster No. 1202 Meniscus Model of Post-Traumatic Osteoarthritis NFAT1 DeficiencyP romotes the Initiation and Michael A David, Melanie K Smith, Avery T White, Progression of Posttraumatic Osteoarthritis Induced Ryan T Locke, Christopher Price by Meniscal Destabilization Yi Feng, Qinghua Lu, William C. Kramer, Nicholas C. Poster No. 1193 Barnthouse, Jinxi Wang Biomechanical Characterization of a New, Noninvasive Model of Anterior Cruciate Ligament Poster No. 1203 Rupture in the Rat Changes in Knee Joint Following Non-Invasive Tibial Tristan Maerz, Michael Kurdziel, Abigail Davidson, Compression in Genetic Mouse Strains Kevin Baker, Kyle Anderson, Howard Matthew Xin Duan, Muhammad F Rai, Nilsson Holguin, Matthew J Silva, Linda J Sandell Poster No. 1194 Chondro-protective Effects of Bisphosphonate for PS2 Cartilage, Synovium and Osteoarthritis - Matrix PTOA Could Attribute to the Inhibition of Chondrocyte Proteins, Collagen and Proteoglycans Mevalonate Pathway Yilu Zhou, Miri Park, Monideepa Chatterjee, Jie Ma, Lea Poster No. 1204 Fang, Liyun Wang, X. Lucas Lu L ocal intra-articular Injection of Rapamycin Delays Articular Cartilage Degeneration Poster No. 1195 in a Murine Model of Osteoarthritis Establishment Of Surgical Destabilization Model Of Koji Takayama, Yohei Kawakami, Makoto Kobayashi, Mouse Ankle Osteoarthritis Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka, Song Ho Chang, Tetsuro Yasui, Sakae Tanaka, Taku Saito Freddie H Fu, Johnny Huard

Poster No. 1196 Poster No. 1205 POSTERS Impact-induced Fissuring at High Strain Rates Rock Inhibitor Prevents Mmp-3 Expression And in Adult Equine Hock Cartilage Maintains Aggrecan Production in Human Corinne R. Henak, Lena R. Bartell, Lisa A. Fortier, Articular Chondrocytes Itai Cohen, Lawrence J. Bonassar Hiroto Inoue, Takayuki Furumatsu, Shinichi Miyazawa, Takaaki Tanaka, Toshifumi Ozaki Poster No. 1197 Changes of Cartilage Composition and Surface Poster No. 1206 Roughness One Week After MMT Surgery Aggrecan Core Protein Length Is Reduced In David S Reece, Tanushree Thote, Angela Lin, Nick J Willett, Intervertebral Disc Compared With Articular Cartilage Robert E Guldberg Derived Aggrecan Russell James Craddock, Michael J Sherratt, Sarah H Cartmell, Judith A Hoyland

105 Poster No. 1207 Poster No. 1215 Topographical Investigation Of Changes In Depth- Topological Match of Medial and Lateral Femoral wise Proteoglycan Distribution Of Rabbit Articular Condyle Donor Osteochondral Grafts to Medial Cartilage 4 Weeks After Transection Of The Anterior Femoral Condyle Recipient Sites Cruciate Ligament Bradley C Hansen, Esther Cory, Matthew T Provencher, James M Fick, Mikko E Arokoski, Jukka S Jurvelin, William D Bugbee, Timothy S. Mologne, Robert L Sah Rami Korhonen Poster No. 1216 Poster No. 1208 Intra-articular Injection of Synovium-Derived Adjunctive Intra-articular OPF Scaffolds Loaded Mesenchymal Stem Cells with HA Can Repair Articular with Either Celecoxib or DKK-1 (Wnt/β-Catenin Cartilage Defects in a Canine Model Pathway Inhibitor) Do Not Improve The Results of Shinya Miki, Masato Takao, Takashi Matsushita Surgical Contracture Release in a Rabbit model of Arthrofibrosis PS2 Cartilage, Synovium and Osteoarthritis - Mechanics Suenghwan Jo, Luke B Morrey, Matthew Philip Abdel, Joaquin Sanchez-Sotelo, Bernard F Morrey, Mark E Morrey Poster No. 1217 C hondrocyte Mechanics in Intact and Meniscectomy PS2 Cartilage, Synovium and Osteoarthritis - Focal Human Knee Joints During Walking Defect Repair Petri K. Tanska, Mika E Mononen, Rami K Korhonen

Poster No. 1209 Poster No. 1218 Small Subchondral Drill Holes Improve Marrow Kinematics of Ligament-Transected Mouse Knees using Stimulation of Articular Cartilage Defects Controlled Tibial Compressive Loading Mona Eldracher, Patrick Orth, Magali Cucchiarini, Dieter Olufunmilayo O Adebayo, Frank C Ko, Steven R Goldring, Michael Kohn, Dietrich Pape, Henning Madry Mary B Goldring, Timothy M Wright, Marjolein C.H. van der Meulen Poster No. 1210 Cartilage Repair With Mesenchymal Stem Cells Is Poster No. 1219 Accelerated By Loading After Temporal Distraction Nanomechanical Properties of Murine Arthroplasty In Rabbits Temporomandibular Joint Cartilaginous Tissues Yohei Harada, Tomoyuki Nakasa, Elhussein Elbadry Basak Doyran, Xingyu Chen, Qing Li, Eiki Koyama, Mahmoud, Goki Kamei, Nobuo Adachi, Masataka Deie, Hyun-Duck Nah, X. Lucas Lu, Lin Han Mitsuo Ochi Poster No. 1220 Poster No. 1211 A Confocal Microscope-Based Method for Mapping Depletion Of Gangliosides Accelerated The Articular Compressive Strains in Murine Cartilage Cartilage Repair In Mice Alexander Kotelsky, Michael Richards, Mark Buckley Masatake Matsuoka, Tomohiro Onodera, Fumio Sasazawa, Daisuke Momma, Rikiya Baba, Kazutoshi Hontani, Poster No. 1221 Norimasa Iwasaki The Effect of Hemiarthroplasty Implant Shape on Early Cartilage Wear in Linear Reciprocal Sliding Poster No. 1212 Alana A Khayat, Dan Langohr, John B Medley, Graham Acetabular Lablum Blood Flow during Periacetabular King, James A Johnson Osteotomy: An Intraoperative In vivo Study using Laser Doppler Flowmetry Poster No. 1222 So Minokawa, Masatoshi Naito, Kouichi Kinoshita, Cartilage Surface Roughness is a Better Predictor of POSTERS Kunihide Muraoka, Tomonobu Hagio, Tetsuya Sakamoto, Coefficient of Friction than Traditional Measures of Tomoko Nagano, Norihito Watanabe, Hajime Seo, Cartilage Wear Tomohiko Minamikawa, Tetsuro Ishimatsu, Satohiro Ishii Benjamin Lakin, Luai Zakaria, Daniel Grasso, Mark Grinstaff, Brian Snyder Poster No. 1213 Pre-clinical Small Animal Model for Osteochondritis Poster No. 1223 Dissecans of the Knee T he Effect of Sliding Speed and Congruence on the Giuliana E. Salazar-Noratto, Nick Willett, Hazel Y Stevens, 24 h Friction Response of Human Glenohumeral Joints Angela Lin, Greg Gibson, Robert E Guldberg Brian Jones, Gerard Ateshian

Poster No. 1214 Poster No. 1224 Articular Cartilage Progenitor Cells for the Repair of Relationship between Quantitative T1ρ and Articular Defects: A Long-Term Strenuous Exercise T2 Relaxation Times and the Biochemical and Model in Horses Biomechanical Properties of Osteoarthritic Cartilage David D Frisbie, Helen McCarthy, Charles Archer, Myra Courtney E Cox, Sophia Y Kim, Amber T. Collins, Sophia N Barrett, C Wayne McIlwraith Ziemian, Charles E Spritzer, Farshid Guilak, Louis E DeFrate, Amy L McNulty

106 Poster No. 1225 PS2 Cartilage, Synovium and Osteoarthritis - Matrix Quantifying Diffusion of Fluorescent Solutes in Degradation Strained Porous, Viscoelastic Materials Using Correlation Spectroscopy Poster No. 1233 Janty Shoga, Christopher Price Early Changes in Synovial Protease Gene Expression after Surgical Induction of Post-Traumatic Poster No. 1226 Osteoarthritis in a Porcine Large Animal Model A Technique For Determining The Equilibrium Jakob T Sieker, Ugur M Ayturk, Benedikt L Proffen, Braden Properties of Articular Cartilage From The Short-term C Fleming, Martha M Murray Indentation Poster No. 1234 Xingyu Chen, Brandon K Zimmerman, Michael Furr, X. Magnetic Resonance-Guided Focused Ultrasound for Lucas Lu Treatment of Arthritic Pain in a Sheep Model Adam Wilson, Xuejun Du, Chunxi Yang, Arik Hananel, Poster No. 1227 Xinlin Yang, Jourdan Cancienne, Richard Price, Abhijit Multi-scalar Mechanical Testing of the Calcified Dighe, Quanjun Cui Cartilage and Subchondral Bone Comparing Healthy versus Early Degenerative states Poster No. 1235 Emily Hargave-Thomas, Neil Broom, Ashvin Thambyah Wisp1 Aggravates Osteoarthritis By Modulation Of TGF-β Signaling And Positive Regulation Poster No. 1228 Of Canonical Wnt Signaling Correlation of Non-destructive Electromechanical Martijn H van den Bosch, Arjen B Blom, Azusa Maeda, Probe (Arthro-BST) Assessment with Histological Tina M Kilts, Esmeralda N Blaney Davidson, Wim B van den Scores and Mechanical Properties in Berg, Floris P Lafeber, Peter L van Lent, Marian F Young, Human Tibial Plateau Peter M van der Kraan Sotcheadt Sim, Anik Chevrier, Martin Garon, Eric Quenneville, Michael D Buschmann Poster No. 1236 Nrf2 Is A Novel Regulator Of Sox-9 In Chondrocytes PS2 Cartilage, Synovium and Osteoarthritis - Gene Athanassios Fragoulis, Rainer Beckmann, Claudius Therapy Conrads, Mersedeh Tohidnezhad, Thomas Pufe, Christoph J Wruck, Mary B Goldring, Holger Jahr Poster No. 1229 Effect of Binding Peptide Length and Concentration on Poster No. 1237 Augmentation of IGF-I Gene Therapy for Chondrocytes Akt Activation by Type II Collagen Peptide Leading Izath N Aguilar, Stephen B Trippel, Shuiliang Shi, to Nuclear Factor-κB Up-regulation in Osteoarthritic Lawrence J Bonassar Chondrocytes: Its Inhibition by Hyaluronan Tadashi Yasuda Poster No. 1230 Effects Of Static Versus Dynamic Culture Conditions PS2 Cartilage, Synovium and Osteoarthritis - Tissue Upon The Chondrogenic Differentiation Potentialof Engineering and Repair Human Bone Marrow Aspirates Following rAAV- mediated Overexpression Of sox9 Poster No. 1238 Jagadeesh K Venkatesan, Ana Rey-Rico, Janina Frisch, Acute Injury induced Fibrosis Is Medated Gertrud Schmitt, Henning Madry, Magali Cucchiarini By Lysophosphatidic Acid Ling Wu, Frank Petrigliano 1, Siyoung Lee 1, Poster No. 1231 David McAllister, Denis Evseenko Effects Of rAAV Sox9 Gene Transfer Upon The Chondrogenic Differentiation Of Hmscs Seeded In Poster No. 1239 Polyurethane Scaffolds Comparative Analysis of Human Amnion and Jagadeesh K Venkatesan, Ana Rey -Rico, Oliver Gardner, Adipose Derived Stem Cells for Regenerating Gertrud Schmitt, David Eglin, Mauto Alini, Martin Stoddart, Orthopaedic Tissues

Magali Cucchiarini, Henning Madry Natasha Topoluk, Renae Keeley, Jeremy Mercuri POSTERS

Poster No. 1232 Poster No. 1240 Benefits Of Using PEO-PPO Copolymers For The Delayed Mechanical Loading for The Rehabilitation of Effective Delivery Of rAAV Vectors In Human Bone Microfracture Surgery Marrow-derived Mesenchymal Stem Cells Monideepa Chatterjee, Miri Park, Brandon K Zimmerman, Ana Rey Rico, Alvarez-Lorenzo Carmen, Angel Concheiro, X. Lucas Lu Henning Madry, Magali Cucchiarini Poster No. 1241 Cell-Cell Interactions Enhance Cartilage Formation in Gradient Hydrogels that Mimic Tissue Zonal Organization Danqing Zhu, Pavin Trinh, Fan Yang

107 Poster No. 1242 Poster No. 1251 Overexpression of hsa-miR-7 Enhances Cartilage Glucose- and TGF-β-Dependent Matrix Synthesis Regeneration by Osteoarthritic Chondrocytes Models Explain Heterogeneous Matrix Lucienne A Vonk, Margit W Bleijs, Angela H Kragten, Deposition in Large Engineered Tissues Wouter J Dhert, Daniel B Saris, Laura B Creemers Robert J Nims, Alexander D. Cigan, Michael B Albro, Clark T. Hung, Gerard A. Ateshian Poster No. 1243 Exploring the Chondrogenic Effects and Mechanisms Poster No. 1252 of Suramin on Mesenchymal Stem Cells Cartilage Mechanobiology: Is It Governed By Monica P McNerney, Andrew J Steward, Diane R Wagner Solid- Or Fluid-dependent Phenomena? Philippe Abdel-Sayed, Stefania Rissone, Dominique Pioletti

Poster No. 1244 Poster No. 1253 The Effect Of Superimposed Vibrations On Genome Engineering Using CRISPR/Cas9 To Generate Chondrocytes Subjected To Dynamic Il-1-resistant Induced Pluripotent Stem Cells For Compressive Loding Cartilage Tissue Engineering Joanna Weber, Stephen Waldman Jonathan M Brunger, Ananya Zutshi, Vincent P. Willard, Charles A. Gersbach, Farshid Guilak Poster No. 1245 Controlling The Formation Of Mechanically Strong Poster No. 1254 Cartilage By Self-assembly Of hMSCs On Substrate Evaluation of Micro and Nano-scale Scaffold Coated Membrane Inserts Architectures For Osteochondral Tissue Engineering Johnathan Ng, Sarindr Bhumiratana, Ming Li, Liliana F. Mellor, Saahil Mehendale, Mahsa Mohiti-Asli, Gordana Vunjak-Novakovic Michael A. Taylor, Christian Pedersen, Rohan A. Shirwaiker, Elizabeth G. Loboa Poster No. 1246 Heterogeneous Growth of Engineered Cartilage Poster No. 1255 Results From Gradients of Media Supplemented Active Scaling Media to Construct Surface Area Improves TGF-β and is Ameliorated Through the Alternative Functional Maturation of Mesenchymal Stem-Based Supplementation of Latent TGF-β Engineered Cartilage Michael B Albro, Robert J Nims, Krista M Durney, Elizabeth A Henning, Megan J Farrell, David R Steinberg, Alexander D Cigan, Jay J Shim, Gordana Vunjak-Novakovic, Robert L Mauck Clark T Hung, Gerard A Ateshian Poster No. 1256 Poster No. 1247 Biphasic Finite Element Modeling Reconciles Comparison of Insulin, ITS And ITS+ On The Mechanical Properties of Engineered Cartilage Development of Tissue-Engineered Cartilage Constructs Derived from Different Testing Modalities Terri-Ann N Kelly, Paola A Lopez, Andrea R Tan, Michael K Gregory R Meloni, Brendan D Stoeckl, Matthew B Fisher, Dermksian, Christine Chen, Aaron M Stoker, James L Cook, George R Dodge, Robert L Mauck Gerard A Ateshian, Clark T Hung Poster No. 1257 Poster No. 1248 Anatomic Mesenchymal Stem Cell-Seeded Engineered Modulation of Hydrogel Crosslinking Density to Cartilage Constructs for Biologic Joint Replacement Promote Development of Functional Mechanical Vishal Saxena, Minwook Kim, Robert L. Mauck Properties in Engineered Cartilage Eben G Estell, Andrea Tan, Sonia Bansal, Poster No. 1258 POSTERS Gerard Ateshian, Clark T. Hung Human Amniotic Fluid-derived Stem Cells As A Novel Cell Type To Enhance Cartilage Repair In Combination Poster No. 1249 With Hypoxia And A Collagen-hyaluronic Acid Scaffold Characterization of a Human Chondrocyte-Agarose Cai Lloyd-Griffith, Amos Matsiko, Garry P Duffy, System for Engineering Cartilage: The Importance of Fergal J O’Brien Cell Seeding Density Alexander D Cigan, Robert J Nims, Michael B Albro, Poster No. 1259 Brian K Jones, Hadley J Feingold, Gordana Vunjak- The Bioengineering Chondrocyte Sheets Novakovic, Clark T Hung, Gerard A Ateshian Serves As Cell Sourse For Cartilage Repair Ryo Shimizu, Naosuke Kamei, Nobuo Adachi, Mitsuo Ochi Poster No. 1250 Long-Term Storage and Preservation of Tissue Poster No. 1260 Engineered Articular Cartilage Improved Collagen Type II Expression In Adam B Nover, Stephanie L Lee, William T Yu, Robert M Chondrocytes Under Physiological Osmolarity Stefani, Gerard A Ateshian, Aaron M Stoker, James L Cook, Upon Tgfβ2 Knockdown Clark T Hung Ufuk Tan Timur, Anna van der Windt, Esther Haak, Harrie Weinans, Jenny Visser, Tim J Welting, Marjolein Caron, Pieter J Emans, Holger Jahr

108 Poster No. 1261 Poster No. 1270 Novel Infrared Parameters for Assessment of Full- Ligand Dependent RARγ Signaling Regulates depth Matrix Changes in Engineered Cartilage Chondrocyte Maturation in Growth Plate Uday P Palukuru, Cushla McGoverin, Ramya Ailavajhala, Kenta Uchibe, Agnese Di Rocco, Rebecca Berger, Sayantani Farzad Yousefi, Nicholas Cacesse, Padraig Glenn, Nancy Sinha, Colleen Larmour, Motomi Enomoto-Iwamoto, Pleshko Masahiro Iwamoto

Poster No. 1262 Poster No. 1271 Friction-Based Detection of Damage Resulting Hypoxia-Inducible Factor 3-alpha Expression is From the Application of Frictional-Shear Stress on Associated with the Stable Chondrocyte Phenotype in Engineered Cartilage Human Chondrogenic Cells and Tissues G. Adam Whitney, Joseph Mansour, James E Dennis Brandon D Markway, Holly Cho, Jevgenia Zilberman- Rudenko, Paul Holden, Audrey McAlinden, Brian Poster No. 1263 Johnstone Hybrid 3-Dimensional Nanofiber Scaffold For Articular Cartilage Engineering Philip Tatman, William Gerull, Jeffrey Davis, Poster No. 1272 Sean Sweeney-Easter, Albert O Gee, Deok-Ho Kim Early Detection Of Growth Plate Change Using MR Images After Growth Plate Injury Poster No. 1264 Masashi Nakase, Wook-Cheol Kim, Kazuya Ikoma, Motoo Effect of Molecular Weight Of Hyaluronan on Hosokawa, Takashi Yoshida, Yoshinobu Oka, Naotake Chondrogenic Effect in Adipose Derived Stem Cells Yamada, Yoshihiro Kotoura, Atsushi Nishida, Kouichi Shun Cheng Wu, Je Ken Chang, Mei Ling Ho Yokozeki, Mitsuhiro Kawata, Toshikazu Kubo

Poster No. 1265 Poster No. 1273 Measurement Of Residual Enzyme And Role of Apoptosis in Development of Early Enzyme Penetration Depth In Partially Osteochondrosis Digested Cartilage Tissue Stacy Semevolos, Katja Duesterdieck-Zellmer, Powei Lee, Chunan Chen, Alex McNally, Kurt Sly, Maureen Larson Chris Chapman, Steve Lin PS2 Cartilage, Synovium and Osteoarthritis - PS2 Cartilage, Synovium and Osteoarthritis - Growth Mechanobiology Plate and Endochondral Ossification Poster No. 1274 Poster No. 1266 Seamless Multiscale Imaging and Computational Nell-1 Restores Delayed Chondrocyte Maturation Modeling of Molecular Communication in the Caused by Runx2 Deficiency Osteoarthritic Knee Joint Chen-Shuang Li, Caroline Chung, Jie Jiang, Xinli Zhang, Lauren Kark, Lucy Armitage, Dan Hageman, Roy K Aaron, Kang Ting, Chia Soo Melissa L. Knothe Tate

Poster No. 1267 Poster No. 1275 Contrast Enhanced Micro-Computed Tomography of Osteoarthritis-like Phenotype Induced By Advanced Growth Plate Injury Glycation Endproducts Alters Chondrocyte Lauren M Mangano, Louis Gerstenfeld, Elise F Morgan Cytoskeleton Organization, Mechanical Properties, And Metabolic Activity Poster No. 1268 Jenny Liu, Alisa Moyer, Kaixi Wang, Simon Tang 3T MRI, Histologic and Second Harmonic Generation Microscopic Evaluation of Femoral Poster No. 1276 Trochlear Epiphyseal Growth Cartilage Matrix Effect of Counterface on Cartilage Boundary and Vascularization of Foals Predisposed To Lubricating Ability by Proteoglycan 4 and Hyaluronan:

Osteochondrosis Cartilage-Glass vs Cartilage-Cartilage POSTERS Gabrielle Martel, Sabrina Kiss, Charles-André Couture, Saleem Abubacker, Allison E McPeak, Sam G Dorosz, Philip Guillaume Gilbert, Hélène Richard, Thomas Moser, François Egberts, Tannin A Schmidt Légaré, Sheila Laverty Poster No. 1277 Poster No. 1269 Metabolic Activities in Mevalonate Pathway could Histological Characterization of Joint Lesions in a affect theI ntracellular Calcium Signaling of In Situ Feline Model of SandhoffD isease Chondrocytes Cathy S Carlson, Elizabeth R. Nussbaum, Patricia Jie Ma, Yilu Zhou, Liyun Wang, X. Lucas Lu Beadlescomb, Miguel Sena-Esteves, Ashley N. Randle, Aime K Johnson, D. Ray Wilhite, Douglas R. Martin, Poster No. 1278 Margaret McNulty Mechanical Activation of the Mammalian Target of Rapamycin Complex 2 Signaling is Required for Stimulation of the Hypertrophic Marker Type X Collagen in Chondrocytes Yingjie Guan, Xu Yang, Qian Chen 109 Poster No. 1279 Poster No. 1289 Confined Compression of Chondrocyte-Hydrogel Increased Synovial-Based Inflammation in Construct Leads to Highly Inhomogeneous Strain Glenohumeral Rotator CuffT ears and Osteoarthritis Distribution Within Geoffrey D Abrams, Ayala Luria, Rebecca A Carr, Sophia Leung, Susan McGlashan, Jillian Cornish, David Christopher Rhodes, William H Robinson, Jeremy Sokolove Musson, Iain Anderson, Vickie Shim Poster No. 1290 Poster No. 1280 Cyclic Compressive Load To Three-dimensional A Stoichiometric Matrix Model of the Biochemical Cultured Tissue Derived From Human Synovial Network of Central Energy Metabolism in Human Cells Cells Up-regulates Prostaglandin E2 Production for Understanding Chondrocyte Mechanotransduction Through Il6 Signaling Cody Minor, Daniel Salinas, Ross P Carlson, Brendan Yuzuru Ueda, Yasukazu Yonetani, Shinya Yatani, Tomoko Mumey, Ronald June Okamoto, Fuminori Kawano, Naoya Nakai, Tatsuo Mae, Hideki Yoshikawa, Ken Nakata Poster No. 1281 Whole Body Vibration Increases Cartilage Thickness Poster No. 1291 Without Histopathologic Changes IL-15 Induces Increased Matrix Metalloproteinase-1 William Runge, Laurence Dahners, Denis Marcellin-Little, and -3 release from Human Articular Cartilage Stephen Kallianos, Paul S Weinhold Anjali Nair, Arnavaz Hakimiyan, Lev Rappaport, Arkady Margulis, Susanna G Chubinskaya, Carla R Scanzello Poster No. 1282 Proliferation And Metabolic Function Regulated With Poster No. 1292 Hydrostatic And Compressive Distortional Stresses In Reduced Expression of Circadian Rhythm Genes in Human Articular Chondrocytes In Vitro Human Osteoarthritis Cartilage: Suppression of NR1D1 Takahiro Ogura, Akihiro Tsuchiya, Andreas Gomoll, Tom and BMAL1 Alters TGF-β Signaling in Chondrocytes Minas, Thomas S Thornhill, Shuichi Mizuno Ryuichiro Akagi, Kathleen M Fisch, Oscar Alvarez-Garcia, Takeshi Teramura, Yuta Muramatsu, Masahiko Saito, PS2 Cartilage, Synovium and Osteoarthritis - Cytokines, Takahisa Sasho, Andrew I Su, Martin Lotz Inflammation Poster No. 1293 Poster No. 1283 Hyperglycemia-induced Inflammatory Responses Responses of Infrapatellar Fat Pad to Cytokine and Collagen Degradation in Human Chondrocytes Stimulation In Vitro and Diabetic Mouse Cartilages via a PPARγ Signaling Aaron Stoker, Catherine Jones, James L Cook Pathway Shing H Liu, Ying-Ju Chen, Chen Y Chiu, Rong S Yang Poster No. 1284 Effects of PRP on Subacromial Bursal Synoviocytes Poster No. 1294 Hyang Kim, Seung-Yeon Lee, Hye-Youn Kim, Ji-Sun Shin, Effects Of PRP And Dexamethasone On Synoviocytes Won-Kee Park, Kang Sup Yoon, Chris Hyunchul Jo Hyang Kim, Seung-Yeon Lee, Hye-Youn Kim, Ji-Sun Shin, Won-Kee Park, Kang Sup Yoon, Chris Hyunchul Jo Poster No. 1285 Synovium-Derived Mesenchymal Stem Cells Poster No. 1295 Inhibit Inflammatory Processes of Chondrocytes Hyaluronan Inhibits Tlr-4 Dependent Rankl And From Osteoarthritis Patients in Noncontact Cathepsin K Expression In Human Rheumatoid Coculture Systems Arthritis Synovial Fibroblasts EH Lee, Kee Yun Chung, HJ Min, SY Wang, HJ Park, Hyuksoo Tatsuo Watanabe, Toshihisa Kojima, Nobunori Takahashi, POSTERS Han, Sahnghoon Lee, Myung Chul Lee Naoki Ishiguro

Poster No. 1286 Poster No. 1296 Indication of IRE1 Endonuclease Specific Biological Effect of Regulatory T Cells by Tocilizumab Inhibitor for Rheumatoid Synovitis and Its Predictive Therapeutic Gain Factor in Soutarou Izumi, Tomoyuki Nakasa, Shigeru Miyaki, Rheumatoid Arthritis Patients Mitsuo Ochi Tomoaki Yoshikawa, Toru Yamakawa, Kunikazu Ogawa, Mamoru Matsumoto, Satoshi Hosoi, Akihiro Sudo Poster No. 1287 Centrosomal Protein 70kda Is Down-regulated Poster No. 1297 By Decoy Receptor 3 In Specifically Rheumatoid Β Induced Smad1/5 And Smad2/3 Phosphorylation Is Synovial Fibroblasts Both Alk5 And Tak1 Dependent in Chondrocytes Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Arjan van Caam, Wojciech Madej, Esmeralda Blaney Hayashi, Masahiro Kurosaka Davidson, Peter van der Kraan

Poster No. 1288 Poster No. 1298 Lubricin/Proteoglycan-4 Inhibits Pro-inflammatory Vitamin D Analogue For The Inhibition Of Matrix Cytokine Induced Synoviocyte Proliferation via Metalloproteinases (mmps) In Treatment Of CD44-Interaction Osteoarthritis Afnan Al-Sharif, Tannin Schmidt, Gregory Jay, Hongsik Cho, Alexander Hicks, Keith Nord, Margaret 110 Khaled A Elsaid Powell, Andrzej Slominski, Karen A Hasty Poster No. 1299 Poster No. 1309 Comparison of Synovial and Infrapatellar Fat Pad Link N Suppresses Interleukin-1β Induced Human Tissue Response to Cytokine Stimulation Using an In Osteoarthritic Cartilage Degradation Through Down- Vitro Co-culture Model regulation of NF-κB Signalling Nicole Walden, Aaron Stoker, Nikki Werner, James L Cook Omar Salem, Motaz Alaqeel, Michael P Grant, Laura Mery Epure, Olga L Huk, John Antoniou, Fackson Mwale Poster No. 1300 Synovial Stimulation of Sensory Neurons by Nerve Poster No. 1310 Growth Factor Augments Osteoarthritic Pain Restoration of Chondroprotection by rhPRG4 in IL-1κ Xin Li Stimulated Cartilage Explants Katherine Larson, Gregory Jay, Braden Fleming, Tannin PS2 Cartilage, Synovium and Osteoarthritis - Aging Schmidt, Khaled A Elsaid

Poster No. 1301 Poster No. 1311 Tristetraprolin Is A Negative Regulator Of SOX9 mRNA scAAVIL-1ra Dosing Trial in a Large Animal Model And Binds To Sequences Within Its 3’UTR and Validation of Long-Term Expression with Repeat Ben T McDermott, Peter D Clegg, Simon R Tew Administration for Osteoarthritis Therapy Laurie R Goodrich, Joshua Grieger, Jennifer Phillips, Nadia Poster No. 1302 Khan, Steven Gray, C Wayne McIlwraith, R. Jude Samulski Endoplasmic Reticulum (er) Stress Induces Mitochondrial Dysfunction In Chondrocytes PS2 Cartilage, Synovium and Osteoarthritis - Raghunatha Yammani Osteoarthritis - Clinical

Poster No. 1303 Poster No. 1312 Decreased Hdac4 Plays A Critical Role In Human Oa Hypercoagulability and Arterial Cartilage Degeneration By Releasing Hdac4 Inhibition Pathology in Human Osteoarthritis Of Runx2 And Increasing Oa-related Genes Roy K Aaron, Manuel Garcia Toca, Anne Voisinet, Kun Cao, Xiaochun Wei, Li Guo, Shaowei Wang, Pengcui Li, Jennifer Racine Changqi Sun, Lei Wei Poster No. 1313 Poster No. 1304 Bone Turnover Markers In The Synovial Fluid are Potent Role Of Sirt6 In The Crosstalk Between Correlated With The Articular Cartilage Loss In The Metabolic Syndrome And Osteoarthritis Patients With Knee Osteoarthritis Ailixiding Maierhaba, Aibibula Zulipiya, Iwata Munetaka, Kenichi Kurata, Yoshitomo Saita, Taisuke Satou, Ryo Jinying Piao, Guangwen Jin, Daisuke Koga, Atsushi Okawa, Sadatsuki, Yohei Kobayashi, Syunya Kamano, Susumu Sadao Morita, Yoshinori Asou Fukasaku, Kazuo Kaneko, Masayuki Nemoto

PS2 Cartilage, Synovium and Osteoarthritis - Poster No. 1314 Osteoarthritis - Therapies Chondrotoxic Effects of Local Analgesics: Effect of Lidocaine on chondrocytes under Low Osmotic Poster No. 1305 Conditions As Seen in Osteoarthritis NBQX, An AMPA-Kainate Glutamate Receptor Shigeru Kobayashi, Tsuyoshi Miyazaki, Kenichi Takeno Antagonist, Alleviates Inflammation And Pain Related Behaviour In Two Models Of Osteoarthritis PS2 Cartilage, Synovium and Osteoarthritis - Cleo S Bonnet, Sophie J Gilbert, Anwen S Williams, David A Progenitors and Stem Cells Walsh, Deborah J Mason Poster No. 1315 Poster No. 1306 Effect Of Parathyroid Hormone On Early Chondrogenic Effect of Preparation Technique on Anti-inflammatory Differentiation From Mesenchymal Stem Cells Properties of Autologous Therapies Ken Kumagai, Yun Zhang, Tomoyuki Saito

William King, Kathleen Steckbeck, Krista O’Shaughnessey POSTERS Toler, Jennifer Woodell-May Poster No. 1316 Chondrogenesis Of Human Embryonic Stem- Poster No. 1307 derived Progenitor Cells In A High-throughput Thermal Therapy with a Resonant Cavity Applicator for Three-dimensional Culture System: Application To A Osteoarthritis Metabolic Study Akiko Sato, Kenji Takahashi, Yasuhiro Shindo, Kazuo Kato, Shintaro Shoju, Mary Lenz, Hal Sternberg, Francois Binette, Hiroshi Nakamura, Shinro Takai Koichi Masuda

Poster No. 1308 Poster No. 1317 Gro-alpha Induces Il-6 Production In Human Synovial Characterizing the Cellular Response of the Fibroblasts Through Fak, Mapk And Ap-1 Pathways Articular Cartilage at the Ankle to Injury by Cyclical Ju-Fang Liu, Sheng Mou Hou, Chun Han Hou Compression in a Mouse Tarik S Onur, Ruobin Wu, Stacey T. Chu, Cole Sitron, Wenhan Chang, Alexis B.C. Dang

111 Poster No. 1318 PS2 Meniscus - Biology and Repair Clinical Reaction After Repeated Intra-articular Injection Of Allogeneic Mscs Compared To Poster No. 1327 Autologous In Normal Joints Intra-articular Injection Of Synthetic Microrna-210 Ashlee Watts, Amanda-Jo Joswig, Roger Smith, Accelerates Avascular Meniscal Healing In Rat Chad Marsh, Kevin Cummings Medial Meniscal Injured Model Yoshitaka Kawanishi, Tomoyuki Nakasa, Takeshi Shoji, Poster No. 1319 Michio Hamanishi, Ryo Shimizu, Naosuke Kamei, Reconstruction Of Osteochondral Defects Using Muhammad Andry Usman, Mitsuo Ochi A Microenvironment Created From Autologous Endothelial Progenitor Cells And Porous Plga Poster No. 1328 Scaffolds In A Rabbit Model Seamless Healing of Inner Meniscus Tears by Temporal Tzu-Hsiang Lin, Nai-Jen Chang, Horng-Chaung Hsu, Control of Stem Cells Recruitment and Step-Wise Ming-Long Yeh Fibrocartilaginous Differentiation Chang H Lee, Kristy Kao, Yena Jun, David Joo Poster No. 1320 Mesenchymal Stem Cell Differentiation in Agarose Poster No. 1329 Scaffolds is Superior to Differentiation in Collagen Meniscal Regeneration using a Bovine Scaffolds for Cartilage Tissue Engineering Applications Dermal Collagen Matrix Jose L Ramirez-GarciaLuna, Antonio A Gordillo-Moscoso, Mark A Randolph, Sanford C Edwards, Juan M Shiguetomi-Medina, America S Mares-Garcia, Amanda M Meppelink, Thomas J Gill Jorge F Toro-Vazquez, Mauricio Pierdant-Perez Poster No. 1330 PS2 Meniscus - Mechanics Photochemical Tissue Bonding of Fibrocartilage: A Potential Tool for Enhancing Meniscus Repair Poster No. 1321 Joy A Franco, Alberto L Arvayo, Marc E Levenston A Statistically-Augmented Computational Platform For Designing And Optimizing Meniscal Replacements Poster No. 1331 Hongqiang Guo, Thomas J Santner, Tony Chen, Hongsheng Mesenchymal Stem Cell Phenotype Changes in Wang, Caroline Brial, Susannah Gilbert, Matthew F Koff, 3D Co-Culture with Meniscus Fibrochondrocytes Amy L Lerner, Suzanne A Maher Mary Clare McCorry, Lawrence Bonassar

Poster No. 1322 Poster No. 1332 Micromechanical Heterogeneity and Anisotropy Hyaluronan Modulates Gene Expression And of the Meniscus Extracellular Matrix Proliferative Activity In Human Meniscus Cells Qing Li, Feini Qu, Biao Han, Robert Mauck, Lin Han Takaaki Tanaka, Takayuki Furumatsu, Shinichi Miyazawa, Masataka Fujii, Hiroto Inoue, Naoko Kashihara, Poster No. 1323 Toshifumi Ozaki Meniscal Material Properties Obtained From In Vitro MRI Data Poster No. 1333 Maren Freutel, Fabio Galbusera, Anita Ignatius, The Role of the Hypoxia-inducible Factor (HIF) Lutz Dürselen Pathway in Normal and Osteoarthritic Meniscus Austin V Stone, Richard F Loeser, Michael Callahan, Kadie Poster No. 1324 S Vanderman, David L Long, Margaret A McNulty, Raghu Strain-Dependent and Anistropic Diffusion of Yammani, Cristin M Ferguson Glucose in Meniscus Fibrocartilage POSTERS Kelsey L Kleinhans, Lukas M Jaworski, Alicia R Jackson Poster No. 1334 Histopathologic Analysis of Degenerative Meniscal Poster No. 1325 Root Tears; Emphasis on Fibrocartilage Formation Comparing the Transient Osmotic Swelling of and Calcification Articular Cartilage and Meniscal Fibrocartilage in Do Young Park, Byoung-Hyun Min ConfinedC ompression Eva G Baylon, Marc E Levenston Poster No. 1335 Analysis of the Metabolic Response of Meniscal Poster No. 1326 Tissue to Injury and Inflammation in vitro Biomechanics of the Transitional Zone between the Alex Cook, Aaron Stoker, Ferris Pfeiffer, James L Cook Meniscus and Its Ligamentous Attachments Lutz Dürselen, Natalie B Scholz, Andreas M Seitz, Anita Ignatius, Maren Freutel

112 PS2 Tendon/Ligament - Progenitors and Stem Cells Poster No. 1345 Fibrin Glue Does Not Improve Rotator Cuff Poster No. 1336 Healing in a Rat Model Hypoxic Culture Conditions Induce Increased Michael Schaer, Richard Ma, Marco Sisto, Will Gu, Metabolic Rate and Collagen Expression in Ashley Titan, Xiang-Hua Deng, Scott Rodeo ACL-derived Cells Tomasz J Kowalski, Natalie Leong, Ling Wu, Nima Kabir, Poster No. 1346 Adam Khan, Andrew Pedron, Ashant Karayant, Siyoung Comparison Of Cellular Composition and Cytokine- Siyoung, Benjamin Wu, Denis Evseenko, David R McAllister, release Kinetics according to the Platelet-rich Plasmas Frank A Petrigliano (PRPs) Preparation Joo Han Oh, Young Hak Roh, Woo Kim Poster No. 1337 Effects Of High Glucose On Cell Apoptosis, Cell Poster No. 1347 Proliferation And Tenogenic Marker Expression Of The Effect of PRP with Gelatin Hydrogel Tendon-derived Stem Cells In Vitro Sheets on Rotator Cuff Repair Yu-Cheng Lin, Chen Wang, Xin Zhang, Liu Shi, Yukichi Kabuto, Toru Morihara, Tsuyoshi Sukenari, Yun-Feng Rui Yoshikazu Kida, Hiroyoshi Fujiwara, Ryo Oda, Yuji Arai, Ken-ichi Matsuda, Mitsuhiro Kawata, Yasuhiko Tabata, Poster No. 1338 Toshikazu Kubo The Effects of Fibrin Gel on Viability of Bone Marrow Stem Cells Poster No. 1348 Kosuke Uehara, Chunfeng Zhao, Anne Gingery, Flat and 3D Electrospun Scaffolds for Ligament Tissue Andrew Thoreson, Kai-Nan An, Peter C. Amadio Engineering: Mechanical Properties and Cellular Response Poster No. 1339 Hannah Pauly, Ketul Popat, Daniel Kelly, Tammy Donahue An Irradiation-And-Injection Approach to Study TSC Differentiation in a Mouse Treadmill Running Model Poster No. 1349 Jianying Zhang, James H-C. Wang Evaluation of Bioadhesive Mesh Construct to Augment Achilles Tendon Repair in a Rabbit Model PS2 Tendon/Ligament - Repair and Tissue Engineering Yan Lu, Brett Nemke, Jackie Kondratko, Vicki kalscheur, Gino Bradica, Ray Vanderby, Mark D. Markel Poster No. 1340 Multidisciplinary Evaluation of Treatments for Poster No. 1350 Achilles Tendon Ruptures During Early Healing Characterization And In Vivo Response Of A in an Animal Model Mechanically-active Shape-Memory Fabric For Soft- Benjamin R Freedman, Joshua A Gordon, Stephen J tissue Repair Thomas, Pankti B Bhatt, Corinne N Riggin, Joseph J Sarver, David L. Safranski, Kenneth M Dupont, Cambre Kelly, Jennica J Tucker, Robert Zanes, Adam Pardes, Dong Y Lee, Jennifer Boothby, Angela Lin, Hazel Y Stevens, Robert E Michael W Hast, Louis Soslowsky Guldberg

Poster No. 1341 Poster No. 1351 Modulation of Rat Ligament Healing using Primed Synergistic Effects of Mechanical Stimulation and Mesenchymal Stem Cells PDGF Nanoparticles on Tenocyte Differentiation of Erin Saether, Connie Chamberlain, Stacey Brickson, Erdem Adipose-Derived Stem Cells on Aligned Collagen Aktas, Ray Vanderby Scaffolds Douglas A. Cornet, Larry D. Swain, David D Dean, Xingguo Poster No. 1342 Cheng, Daniel P Nicolella, Ramesh C. Srinivasan, Victor In Vivo Evaluation of Tissue-Engineered Constructs for Louis Sylvia Anterior Cruciate Ligament Reconstruction Natalie L Leong, Nima Kabir, Armin Arshi, Azadeh Nazemi, Poster No. 1352

Frank A Petrigliano, Benjamin Wu, David R McAllister BMP13 Up-regulates Genes Critical To Early Tendon POSTERS Healing In Immortalized Tenocytes Poster No. 1343 Sahitya K Denduluri, Bryan Scott, Joseph Daniel Lamplot, Silk/Hydroxyapatite Composite Scaffold for Soft- Tong-Chuan He to-Hard Tissue Interface Regeneration in Anterior Cruciate Ligament Reconstruction Poster No. 1353 Thomas K.H. Teh, Pujiang Shi, Kelei Chen, Xiafei Ren, Siew 3D Microarchitecture Quantification Of Bone Lok Toh, James H Hui, Jun Li, James CH Goh Regeneration During Bone-tendon Junction Healing By SR-μCT Poster No. 1344 Daqi Xu, Cheng Zheng, Zhanwen Wang, Can Chen, Huabin What Are The Proteomic Differences Between Tendon, Chen, Jianzhong Hu, Hongbin Lu Ligament And 3D Tissue Engineered Tendon And Ligament Constructs? Yalda Ashraf Kharaz

113 Poster No. 1354 Poster No. 1364 Rotator CuffR epair with a Tendon-Fibrocartilage- WITHDRAWN Bone Composite Bridging Patch Xiaoxi Ji, Qingshan Chen, Andrew R Thoreson, Jin Qu, Poster No. 1365 Kai-Nan An, Peter C. Amadio, Scott P Steinmann, Effect of Short and Long Durations of Systemic Chunfeng Zhao Apoptotic Inhibition on Apoptotic Activity of Fatigue Damaged Patellar Tendons PS2 Tendon/Ligament - Cell Biology Meagan Robles-Harris, Alison Pruzan, Damien Laudier, Evan L Flatow, Nelly Andarawis-Puri Poster No. 1355 Epigenetic Changes In A Murine Model Of Poster No. 1366 Tendinopathy Accumulation Of Pentosidine And Receptors For Katie J Trella, Jun Li, Jonathan Frank, Katalin Mikecz, Advanced Glycation End Products (RAGE) In Jorge Galante, John Sandy, Vincent M Wang, Anna Plaas, The Native Tendon Of Type 2 Diabetes Rat Robert Wysocki Atsushi Yokota, Hiroshi Katoh, Naomune Yamamoto

Poster No. 1356 Poster No. 1367 Probing Potential Mechanisms of Collagen Crimp Three Dimensional Ultrastructural Analysis Of The Formation During Embryonic Tendon Development Postnatal Development At The Supraspinatus Zachary L Tochka, Nathan R Schiele, Catherine K Kuo Insertion With FIB/SEM Tomography Tomonoshin Kanazawa, Masafumi Gotoh, Poster No. 1357 Keisuke Ohta, Kei-ichiro Nakamura, Naoto Shiba Cathepsin Activity in Supraspinatus Tendinopathy: Identification in Human Chronic Tears and Temporal Poster No. 1368 Induction in a Rat Overuse Model Angiopoietin-like Protein 2 Contributes To The Akia N Parks, Song Seto, Jennifer McFaline-Figueroa, Louis Degeneration And Hypertrophy Of Ligamentum J. Soslowsky, Spero Karas, Timothy Ghattas, Harris Slone, Flavum In Lumbar Spinal Canal Stenosis Gregory Tayrose, Manu O. Platt, Johnna Temenoff Takayuki Nakamura, Toru Fujimoto, Takafumi Nakamura, Hiroshi Mizuta Poster No. 1358 Biologic Environment of MRL/MpJ Tendon Healing Poster No. 1369 Correlates With Extent of Ear Punch Regeneration Genome-wide DNA Methylation Analysis David Shiovitz, Harmandeep Singh, Meagan Robles- Of Ligamentum Flavum In Patients With Harris, Rebecca Bell, Arun Fricker, Damien Laudier, Nelly Lumber Spine Stenosis Andarawis-Puri Sadayuki Ito, Ken Watanabe, Taiki Mori, Eri Arai, Yae Kanai, Atsushi Harada, Shumpei Niida, Yoshihito Sakai Poster No. 1359 Ablation Of Hyaluronan Synthase 1 Or 3 Primarily Poster No. 1370 AffectsT he Phenotype Of The Achilles Rather Than Differences in Elements Between Intact and Disrupted The Flexor Digitorum Longus Tendon In Skeletally Human Ligamenta Capitum Femorum Mature Mice Yasushi Shinohara, Tsukasa Kumai, Ichiro Higashiyama, Katie J Trella, Jun Li, Carol DeLa Motte, John Sandy, Anna Yasuhito Tanaka Plaas, Vincent M Wang Poster No. 1371 Poster No. 1360 A Comparison of the Effects of Using Radiofrequency Influence Of Lidocaine On Torn Rotator CuffT endon Energy Compared to Sharp Transection for Tenoscopic POSTERS Hirokazu Honda, Masafumi Gotoh, Tomonoshin Kanazawa, Desmotomy of the Superior Check Ligament in Horses Hidehiro Nakamura, Hiroki Ohzono, Hisao Shimokobe, Brad B Nelson, Chris E. Kawcak, E. J. Ehrhart, Laurie R Naoto Shiba Goodrich

Poster No. 1361 PS2 Tendon/Ligament - Mechanics The Proteome and Turnover rate of the Tendon Interfascicular Matrix Alters with Ageing Poster No. 1372 Chavaunne T Thorpe, Mandy J Peffers, Deborah Simpson, P2 Porous Titanium Implants Improve Early Tendon Elizabeth Halliwell, Hazel RC Screen, Peter Clegg Healing in a Rat Supraspinatus Repair Model Jennica J Tucker, Joshua A Gordon, Robert C Zanes, Poster No. 1362 Andrey Zuskov, James M Cirone, John Vinciguerra, Age-related Changes in Mouse Intrasynovial Tendons Roy D Bloebaum, Louis J Soslowsky Masanori Hayashi, Kazutaka Uemura, Shigeharu Uchiyama, Masatoshi Komatsu, Hiroyuki Kato Poster No. 1373 Tendon Healing in a Supraspinatus Tear and Repair Poster No. 1363 Rat Model is not Altered by Overuse-Induced Overload Damage Results In Early Tendinopathy Inflammation In Tendon Jennica J Tucker, Brianne K Connizzo, Corinne N Riggin, Ewa M Spiesz, Chavaunne T Thorpe, Saira Chaudhry, Robert L Mauck, David R Steinberg, Andrew F Kuntz, Louis Graham P Riley, Helen L Birch, Peter Clegg, Hazel RC J Soslowsky, Joseph Bernstein 114 Screen Poster No. 1374 PS2 Muscle - Biology What Is The Best Candidate Allograft For Acl Reconstruction? An In Vitro Gliding Characteristics Poster No. 1384 And Histological Study In A Canine Model Expression Of Intracellular MMP-2 After Muscle Injury Jin Qu, Andrew Thoreson, Kai-Nan An, Peter C. Amadio, Does Not Increase With Aging Thomas M. Schmid, Chunfeng Zhao Lawrence Lee, Xuhiu Liu, David H Lovett, Hubert Kim

Poster No. 1375 Poster No. 1385 Mechanical Over-loading Induced Non-tenocyte Intronic Transcriptional Regulation of Intracellular Differentiation Of Tscs Is Not Reversible By Rest Matrix Metalloproteinase-2 in Skeletal Muscle Jianying Zhang, James H-C. Wang Ischemia-Reperfusion Injury Sunil Kumar Joshi, Lawrence Lee, Heejae Kang, David Poster No. 1376 Lovett, Christopher Owens, Hubert Kim, Xuhui Liu Elastin Governs the Extracellular Mechanical Response of Ligament Poster No. 1386 Heath B Henninger, William R Valdez, Sara A Scottt, Muscle Atrophy and Fatty Infiltration After an Acute Jeffrey A Weiss Rotator CuffR epair in a Sheep Model Tammy Luan, Xuhui Liu, Jeremiah T Easley, Bharat Poster No. 1377 Ravishankar, Christian Puttlitz, Brian Feeley Functionally Distinct Tendons have Dissimilar Collagen Fibril Architectures and Crosslinking, Leading to Poster No. 1387 Differing Nanoscale Fatigue Damage Susceptibility P21 DeficiencyI mpaired The Regeneration Tyler W Herod, Neil C Chambers, Samuel P Veres Of Skeletal Muscle Nobuaki Chinzei, Shinya Hayashi, Takeshi Ueha, Takaaki Poster No. 1378 Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Shuhei The Effect of Recombinant Human Parathyroid Sakata, Shinsuke Kihara, Katsuhiko Haneda, Yoshitada Hormone (rhPTH) on Tendon-to-Bone Healing Sakai, Ryosuke Kuroda, Masahiro Kurosaka in a Rat Rotator Cuff Model Kyle R Duchman, Jessica Goetz, Bastian Uribe, Andrew Poster No. 1388 Amendola, Joshua Barber, Allison Malandra, A Screening To Identify A Clinically Applicable Drug Carolyn Hettrich Enhancing Muscle Growth For Sarcopenia And Other Muscle Wasting Diseases Poster No. 1379 Tetsuro Hida, Bisei Ohkawara, Masaki Matsushita, Mikito Comparison of EDC and Genipin Crosslinking to Tsushima, Shiro Imagama, Naoki Ishiguro Stabilize Tendon Allografts after Sterilization Justin W Rice, Aaron U. Seto, Christopher Mino, David Poster No. 1389 Macknet, Charles J Gatt, Michael G Dunn Resveratrol Regulates RhoA GTPase And Decreases ROS Induced Apoptosis In Muscle Stem Cells Isolated Poster No. 1380 From A Mouse Model Of Accelerated Aging Anisotropic Nonlinear Material Characterization Xiaodong Mu, Aiping Lu, Mitra Lavasani, Seth David Of The Human Anterior Longitudinal Ligament Thompson, Kurt Weiss, Johnny Huard Mitchell Hortin, Sarah Graham, Kara Boatwright, Peter Hyoung, Anton E Bowden Poster No. 1390 The Role Of Non-myogenic Mesenchymal Stem Poster No. 1381 Cells (nmMscs) In The Skeletal Muscle Pathology Of Tendon Rupture At The Nanoscale: Damage To Muscular Dystrophy Collagen Fibrils Varies Substantially With Both Rupture Jihee Sohn, Ying Tang, Anthony M Ascoli, Aiping Lu, Bing Speed And Tendon Type Wang, Johnny Huard Neil C Chambers, Tyler W Herod, Samuel P Veres Poster No. 1391

Poster No. 1382 Use Of Pulsed Electromagnetic Fields (PEMF) To POSTERS A Novel Study by Confocal Raman Micro-spectroscopy Improve Tenocyte Production Of Fibrotic-related in the Rabbit Bone-tendon Junction of the Patella- Genes In An In Vitro Model patellar Tendon Dominique Laron, Xuhui Liu, Erik Waldorff, James Ryaby, Hongbin Lu, Wang Zhanwen, Jianzhong Hu Jeffrey C Lotz, Brian Feeley

Poster No. 1383 Poster No. 1392 Effect of High Fat Diet and Forced Exercise on Male Effect Of Platelet Rich Plasma On Fatty Degeneration C57BL/6 Achilles Tendon Biomechanical Properties Of Rotator Cuff Muscles In Vitro And In Vivo. Gregory P Boivin, Ryan Roberts, Shawn A Hunter Fumiaki Takase, Atsuyuki Inui, Yutaka Mifune, Tomoyuki Muto, Yoshifumi Harada, Yasuhiro Ueda, Takeshi Kokubu, Masahiro Kurosaka

115 Poster No. 1393 Poster No. 1403 Anabolic Steroids Reduce Muscle Degeneration Hbm Mice Have Altered Bone Compostion Caused by Rotator CuffT endon Release in Sheep Ryan D Ross, Maleeha Mashiatulla, Randy Smith, Lisa Christian Gerber, Dominik C Meyer, Martin Flück, Brigitte Miller, Mark L Johnson, D. Rick Sumner von Rechenberg, Mario Benn, Karl Wieser Poster No. 1404 Poster No. 1394 The Anabolic Effects of Electrical Stimulation Interaction between Myogenic and Non-myogenic on Endochondral Bone Progenitor Cells during Muscle Regeneration Suzanne Lababidi, Ryan Fitzgerald, Kimberly Novak, Aiping Lu, Jihee Sohn, Berkcan Akpinar, Johnny Huard Fouad Moussa, Cale Crowder, Melanie Morscher, Rebecca Kuntz Willits, Dennis Weiner, Fayez Safadi Poster No. 1395 Effects of Platelet-Rich Plasma on Musculotendenious Poster No. 1405 Structure and Limb Function After Induced Tibialis Periosteal Primary Cilia Are Necessary for Postnatal Anterior Strain in Rats Longitudinal Growth in the Appendicular Skeleton Nasr A Abdel-Kader, Aliaa Rehan Youssef, Dina Sabry, Emily Moore, Julia Chen, Christopher Jacobs Lubna O Abdel-Salam, Soheir M Mahfouz, Alaadeen A Balbaa Poster No. 1406 Modulation Of Bone Homeostasis And Suppression Poster No. 1396 Of Adipogenic Differentiation By Sulforaphane, Fatty Degeneration and wnt10b Expression in A Naturally Occurring Isothiocyanate Supraspinatus Muscle after Surgical Repair of Torn Roman Thaler, Scott Riester, Markus Schreiner, Rotator Cuff Tendon. Klaus Klaushofer, Franz Varga, Andre van Wijnen Yoshiyuki Kuwahara, Koshi N Kishimoto, Yoshiaki Itoigawa, Eiji Itoi Poster No. 1407 Viperin Expression in Chondrocytes is Linked Poster No. 1397 to Expression of Col2a1 ASC Myogenesis Within A 3D Fibrin-Nanofiber Mandy M.F. Steinbusch, Marjolein M.J. Caron, Franziska Construct Eckmann, Ekkehart Lausch, Lodewijk W. van Rhijn, Jordana E. Gilbert, Brian Ginn, Pinar Yilgor Huri, Colin A. Bernhard Zabel, Tim J.M. Welting Cook, Joshua P. Temple, Tracy Y. Zhang, Jeffrey M. Gimble, Kathryn Wagner, Hai-Quan Mao, Warren L. Grayson PS2 Bone/Bone Biology - Bone Aging

Poster No. 1398 Poster No. 1408 Reduced Muscle Stem Cells In Situ In Contractures A Bayesian Approach to Assess the Tanscriptome From Children With Cerebral Palsy of Bone Aging and the Role of the Brd2 Gene in the Sudarshan Dayanidhi, Peter B Dykstra, Vera Lyubasyuk, Regulation of Sex Linked Bone Loss Bryon R McKay, Henry Chambers, Richard L Lieber Amira I Hussein, Joseph Wu, Mayetri Gupta, Louis Gerstenfeld Poster No. 1399 Transcutaneous Application Of CO2 Accelerates Poster No. 1409 Muscle Injury Repair In Rat Models Increased CKIP-1 within Osteoblast Suppress BMP Shiho Akahane, Yoshitada Sakai, Takeshi Ueha, Hanako Signaling to Inhibit Bone Formation During Aging Nishimoto, Keisuke Oe, Takahiro Niikura, Ryosuke Kuroda, Jin Liu, Baosheng Guo, Defang Li, Chao Liang, Lei Dang, Masahiro Kurosaka Xiaojuan He, Baoting Zhang, Xiaohua Pan, Lingqiang Zhang, Aiping Lu, Ge Zhang POSTERS Poster No. 1400 Spinal Muscle Quality Changes in Physically Active Poster No. 1410 Individuals with Disc Degeneration Age Diminishes the Upregulation of Wnt Ligands and Ana E Rodriguez Soto, Jessica R Stambaugh, Jeannie Su, the Anabolic Response of Bone to Single and Multiple David B Berry, Sara P Gombatto, Laura Palomno, Karen R Loading Bouts Kelly, Samuel R Ward Nilsson Holguin, Michelle Sanchez, Michael D Brodt, Matthew J Silva Poster No. 1401 Myokines Augment Wnt Signaling By Repressing PS2 Bone/Bone Biology - Genetics, Genomics and Sost Expression Proteomics William Foster, Damian Genetos Poster No. 1411 PS2 Bone/Bone Biology - Skeletal Development An Interleukin-15 Gene Polymorphism Is A Genetic Risk For Radiographic Progression Of Joint Destruction Poster No. 1402 In Anti-citrullinated Peptide Antibody-negative Mechanosensitive MicroRNA-365 Regulates Orofacial Rheumatoid Arthritis Development and Targets Satb2, a Determinant Shinji Yoshida, Katsunori Ikari, Koichiro Yano, Yoshiaki of Craniofacial Patterning and Bone Formation, in Toyama, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Chondro-Lineage Cells Momohara Yun Gao, Kun Yang, Qian Chen 116 Poster No. 1412 Poster No. 1421 Early Histological and Molecular Characterization Exosome-encapsulated miR-214 Secreted from of the Local Tissue Microenvironment Following Osteoclast to Inhibit Osteoblastic Activity Blast-Related Post-Traumatic Injury in a Rat Model of Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Heterotopic Ossification Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang Ammar T Qureshi, Erica Crump, Donald Hope, Gabriel J Pavey, Elizabeth C Martin, Jeffrey Gimble, Jonathan A Poster No. 1422 Forsberg, Thomas A Davis PI3K Signaling Regulates SDF-1-Mediated Recruitment Of Osteoclast Precursors In Poster No. 1413 Homeostasis And During Fracture Genetic Variation in Neuromedin U Influences Lean Vanessa M Scanlon, Do Yu Soung, Naga Suresh Adapala, Body Mass and Bone Morphometry in Males Mark Hansen, Hicham M Drissi, Archana Sanjay Elizabeth A Hedges, Courtney Sprouse, Heather Gordish- Dressman, Michael Liu, Zachary Kendrick, Elizabeth Poster No. 1423 Dominic, Jacqueline McKesey, Leticia M Ryan, Eric Effects Of Megavoltage Irradiation On The Formation Hoffman, Joseph M Devaney, Laura L Tosi And Resorptive Activity Of Osteoclasts In Vitro Elizabeth R. Helffrich, Meagan R. Williams, Eric R. Green, PS2 Bone/Bone Biology - Osteoblasts Matthew J. Allen

Poster No. 1414 Poster No. 1424 Inhibition Of Tgf-β Signaling In Osteoblasts Leads To Notch Signaling is Required for Osteoclast Activation Of Sost And Axin, Sciliosis-like Pathological Differentiation and Function Defects In Mice Jason W Ashley, Jaimo Ahn, Kurt D Hankenson Hsin-Chiu Ho, Shanshan Shi, Tzong-Jen Sheu Poster No. 1425 Poster No. 1415 RING Finger Protein RNF114 Inhibits Pulsed Electromagnetic Fields Stimulate RANKL-induced Osteoclast Maturation Osteogenic Differentiation of MG63 cells by Boren Lin, Qi Ke, Douglas Leaman, Vijay Goel, Modulating Notch Pathway Anand Agarwal Alessia Ongaro, Agnese Pellati, Leila Bagheri, Giorgio Aquila, Paola Rizzo, Stefania Setti, Ruggero Cadossi, PS2 Bone/Bone Biology - Bone Osteocytes and Monica De Mattei Mechanobiology

Poster No. 1416 Poster No. 1426 A Novel Role of miR-150 in Bone Homeostasis OB-Cadherin and N-Cadherin Adhesion Junctions Fouad M. Moussa, Gregory R. Sondag, Kimberly Novak, Differentially Influence the Mechanical Properties of Thomas S. Mbimba, Bing Yu, Fayez F. Safadi 3D Osteogenic Mesenchymal Stem Cell Spheroids Fiona E Griffin, Patrick McGarry, Todd C. McDevitt, Poster No. 1417 Laoise M McNamara (-)-epigallocatechin Gallate Attenuates The Induction Of Hsp27 Stimulated By Sphingosine 1-phosphate Poster No. 1427 Via Suppression Of Phosphatidylinositol 3-kinase/akt Thermally Induced Osteocyte Apoptosis Pathway In Osteoblasts Initiates Pro-osteoclastic And Pro-osteoblastic Jun Mizutani, Takanobu Otsuka, Osamu Kozawa Signaling Responses Eimear B Dolan, Muriel C Voisin, Matthew G Haugh, Poster No. 1418 David Tallon, Laoise M McNamara Pulsed Electromagnetic Field Regulation of TGF-beta Pathway and microRNA21 in Differentiating Human Poster No. 1428 Bone Marrow Stromal Cells towards Osteoblasts Osteocyte-driven Responses To Thermal Zhiming He, Nagarajan Selvamurugan, Jawed A Siddiqui, Elevations In Vivo

Erik I. Waldorff, James T. Ryaby, Nicola C Partridge Eimear B Dolan, David Tallon, Wing-yee Cheung, POSTERS Mitchell B Schaffler, Oran D Kennedy, Laoise M McNamara PS2 Bone/Bone Biology - Osteoclasts Poster No. 1429 Poster No. 1419 LMNA Gene Expression Serves As A Novel Biomarker Bisphosphonates Inhibit Osteosarcoma-mediated For Characterizing Mechanical Phenotype Osteolysis Via Attenuation of Tumor Expression Rafael D Gonzalez Cruz, Vera Fonseca, Manisha Kanthilal, of MCP 1 and RANKL Jessica S Sadick, Eric M Darling Tetsuro Oba, Hirotaka Haro Poster No. 1430 Poster No. 1420 Intracellular and Endoplasmic Reticulum Calcium A Delivery System To Approache Bone Resorption Dynamics in Osteocyte Mechanobiology Surfaces For SpecificallyT argeting Osteoclasts In Vivo Genevieve Brown, Prajesh Desai, X. Edward Guo Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang, Zicai Liang, Aiping Lu, Ge Zhang 117 Poster No. 1431 Poster No. 1441 Bone Cells with Primary Cilia Exhibit High Localized Pigment Epithelium Derived Factor Suppresses Strains Near the Cilium Base when Subjected to Expression Of Sost/sclerostin By Human Osteocytes: Dynamic Fluid Flow A Possible Mechanism By Which It Regulates Matrix Kenneth A. Mann, Megan Elizabeth Oest, Astrid Bakker, Mineralization Anna Fahlgren Feng Li, Na Song, Joyce Tombran-Tink, Christopher Niyibizi

Poster No. 1432 PS2 Bone/Bone Biology - Progenitors and Stem Cells Analyzing the Effect of the Reynolds Number of Flow on Osteocytes Poster No. 1442 Avinash Kondiboyina, Kevin Middleton, Calcium signalling in Response to Fluid Flow Michael Borrett, Xueting Mei, Lidan You within the Primary Cilium Microdomain of Mesenchymal Stem Cells Poster No. 1433 Michele A Corrigan, Kristen L Lee, Marie-Noelle Labour, Mechanical Loading System to Apply Concurrent Christopher R. Jacobs, David A. Hoey Physiological Pressure and Shear to Osteocytes Chao Liu, Frank X Sun, Lidan You Poster No. 1443 Identifying the Role of CD146 in Bone Poster No. 1434 Marrow Stroma in Mice Oscillatory Fluid Flow Represses Sost Expression Andrew J Maul, Luis F. de Castro, Brian J. Sworder, Through The ECR5 Enhancer Paolo Bianco, Pamela G. Robey, Kenn Holmbeck William H. Foster, Gabriela Loots, Damian Genetos Poster No. 1444 Poster No. 1435 Mesenchymal Progenitor Cells Demonstrate Increased Effect Of Two Different Mechanical Stimuli, Osteogenic Differentiation And Enhanced Isolation Shear Stress And Hydrostatic Pressure, On Collagen Nanofiber On Early Humscs Response Ronald Goodlett, Patrick E Jones, Husain Bharmal, Pierre Becquart, Magali Cruel, Herve Petite, Thierry Hoc, Youngmi Ji, Gregory Christopherson, Leon J Nesti Rena Bizios, Delphine Logeart-Avramoglou, Morad Bensidhoum Poster No. 1445 Perlecan/HSPG2 DeficiencyE nhances the Poster No. 1436 Differentiation and Mineralization of Mesenchymal A Microfluidic System to Study Cross-Talk Stromal Cells but Reduces Their Intracellular Calcium between Osteocytes and Osteoclasts Signaling Responses to Fluid Flow Stimulation Kevin Middleton, Xueting Mei, Lidan You Xiaohan Lai, Mengxi Lv, Catherine Kirn-Safran, X. Lucas Lu, Liyun Wang Poster No. 1437 Comparison Of Micro-CT Sampling Methods For Poster No. 1446 The Analysis Of Trabecular Bone Density In A A Simple In-Vitro Fluid Flow Stimulation Platform Rat ACL-transection Model To Enhance Osteogenesis Of Human Mesenchymal Kaitlyn E Chin, Tarpit K Patel, Douglas C Moore, Stem Cells Matthew R Akelman, Benedikt L. Proffen, Martha M Elena Stavenschi, Marie-Noelle Labour, David Hoey Murray, Braden C Fleming Poster No. 1447 Poster No. 1438 G protein-Coupled Estrogen Receptor-1 (GPER-1) The Role of Subchondral Bone Microdamage in Positively Regulates cell proliferation via cAMP/ POSTERS PTOA Following ACL Rupture PKA pathway In Murine Bone Marrow Mesenchymal Matin Lendhey, Bryan Beutel, Oran D Kennedy Stem Cells Shu-Chun Chuang, Po-Lun Hsiao, Mei-Ling Ho, Je-Ken Poster No. 1439 Chang Microdamage and Mechanical Loading Have an Interactive Effect on Remodeling Signals Produced Poster No. 1448 by Osteocyte Transient Receptor Potential Melastatin 7 Is Chao Liu, Xiaoqing Zhang, Michael Wu, Lidan You Mechanosensitive To Shear Flow And Modulates Osteogenic Differentiation Of Mesenchymal Stem Cells Poster No. 1440 Through Osterix Pathway Inhibiting BMP 2/4 Signaling Increases Cancellous Yi-Shiuan Liu, Yu-An Liu, Chin-Ching Huang, Meng-Hua Bone Mass and Reduces Bone’s Response to Yen, Shu Chien, Oscar K. Lee Mechanical Loading in Female Mice Katherine M Melville, Gina Surita, Natalie H. Kelly, R. Scott Poster No. 1449 Pearsall, John C Schimenti, F. Patrick Ross, Marjolein C.H. Bone Marrow-Derived MSC Osteogenesis Requires van der Meulen Endogenous BMP Activity Melody Martychenko, Sushmitha Durgam, Matthew Stewart

118 Poster No. 1450 Poster No. 1459 Macrophages Co-Cultured with MC3T3 Cells Enhanced The Potential of Reference Point Osteogenic Differentiation Microindentation for Fracture Risk Assessment Florence Loi, Ruth Zhang, Katherine Barcay, Heather Thomas Jenkins, Louise V. Coutts, Douglas G. Dunlop, Rogan, Tzu-hua Lin, Jukka Pajarinen, Changchun Fan, Richard O.C. Oreffo, Cyrus Cooper, Nicholas C Harvey, Taishi Sato, Jordan Raphel, Zhenyu Yao, Stuart B Goodman Philipp J Thurner

Poster No. 1451 Poster No. 1460 Dexamethasone Inhibits Production Of Angiogenic Direct and Indirect Raman Signatures of Advanced Factors Associated With Bone Formation By Glycation End Products in Bone Microencapsulated Adipose Stem Cells Cultured In Bo Gong, Erin M McNerny, David H Kohn, Michael D Morris Osteogenic Media Shirae K Leslie, Barbara D Boyan, Zvi Schwartz Poster No. 1461 A Novel Image Transformation Scheme Minimizes PS2 Bone/Bone Biology - Osteoporosis, Metabolic Bone Interpolation Artifact and Allows Reproducible Disease, Biomarkers Measurement of Trabecular Bone Remodeling through μCT-Based In Vivo Dynamic Bone Histomorphometry Poster No. 1452 Chantal M de Bakker, Allison Altman, Connie Li, Mary Beth Parathyroid Hormone, But Not Melatonin, Resets Tribble, Wei-Ju Tseng, X. Sherry Liu The Bone Circadian Clock Naoki Okubo, Yoichi Minami, Hiroyoshi Fujiwara, Tatsuya Poster No. 1462 Kunimoto, Toshihiro Hosokawa, Ryo Oda, Toshikazu Kubo, Analysis Of Signal-to-noise Ratio On Cortical Bone Of Kazuhiro Yagita The Ovariectomized Rats At Primary Stage By Using Mri With Swift Technique Poster No. 1453 Tsuyoshi Sukenari, Motoyuki Horii, Kazuya Ikoma, Keratin Biomaterial for Delivery of rhBMP-2 Masamitsu Kido, Shigeki Hayashi, Yusuke Hara, Promotes Healing of Nonunion Bone Defect in Tetsuro Yamasaki, Ken-ichi Matsuda, Mitsuhiro Kawata, Osteoporotic Model Toshikazu Kubo Ornusa Chalayon, Theresa Pham, Seth Tomblyn, Lindsey Pattison, Luke Burnett Poster No. 1463 45Calcium Used as a Marker of Bone Poster No. 1454 Formation and Metabolism A Non-Weight Bearing Model of Osteoporosis for Nicole Collette, Nicholas Hum, Deepa Murugesh, Michael Histomorphometric and Mechanical Evaluation of Malfatti, Sarah Hatsell, Aris N Economides, Gabriela Loots Bone Repair Using Bone Graft Substitutes Deborah J. Hall, Thomas M Turner, Stephanie M McCarthy, Poster No. 1464 Steven Gitelis, Robert M Urban Females and Males Achieve Equivalent Cortical Bone Mechanical Properties through Different Poster No. 1455 Combinations of Bone Traits Adipose Stem Cell Mediated Calvarial Defect Repair Daniel P Nicolella, Arthur E. Nicholls, Donald Moravits, In An Osteoporotic Rat Model Jennifer A.K. Harris, Shayna M Levine, Matthew R Allen, Ming Pei, Jingting Li, David McConda, Nina Clovis, Jeffry S Nyman, Todd L Bredbenner, Lorena Havill Suzanne Danley PS2 Bone/Bone Biology - Bone Mechanics and Finite Poster No. 1456 Element Analysis Quantal Energy Alters the Rate of Maturation and Enhances the Proliferation and Mineralization of Poster No. 1465 Osteoblasts B iomechanical Numerical Research of Josh M Kolz, Patrick J Hughes, Janine Struve, Scott Disc Displacements Marshall, Richard Davidson, Dorothee Weihrauch, Zhan Liu, Ying-Li Qian, Yu-Bo Fan

James T Ninomiya POSTERS Poster No. 1466 Poster No. 1457 DTS Derived Fractal, LFD and MIL Parameters Fucoidan Inhibits Osteoclast Differentiation Contribute to Prediction of Whole Vertebral Strength And Function By Modulating RANKL Signaling and Energy to Fracture Independent From Bone Mass Seung-Hoon Baek, Young Woo Kim, Tae-Ho Kim, Woong Kim, Daniel Oravec, Angela Xiao, Ellen Yang, Shin-Yoon Kim George Divine, Michael J Flynn, Yener N Yeni

Poster No. 1458 Poster No. 1467 Absence of Complement Component 3 Protects Application and Validation of Multiscale Modeling to Against Bone Loss in a Murine Model of the Distal Radius Postmenopausal Osteoporosis Joshua E. Johnson, Karen L. Troy Danielle L MacKay, Thomas J Kean, Kristina G Bernardi, Feng Lin, James E Dennis

119 Poster No. 1468 PS2 Bone/Bone Biology - Bone Tissue Engineering and Finite Element Analysis of Different Repair Methods Repair of Greater Tuberosity Fractures Under Different Bone Mineral Densities Poster No. 1478 Heng-Jui Liu, Yu-Chih Wang, Wei-Ren Su, Ming-Long Yeh Investigation of Vitreous Carbon Foam as a Bone Graft Substitute in Critical Defects Poster No. 1469 Nora Strong, Stephen Miller, Joel White, Prashanta In-vivo Range Of Motion Of The Tibiotalar And Shrestha, Kim Reuter, Andrea Meyer, Paul Wooley Subtalar Joints During Treadmill Walking And Toe-rise Koren E Roach, Bibo Wang, Ashley Lynn Kapron, Niccolo Poster No. 1479 Fiorentino, Andrew Anderson Vitreous Carbon Foams for Orthopedic Surgeries Stephen Miller, Nora Strong, Joel White, Prashanta Poster No. 1470 Shrestha, Andrea Meyer, Kim Reuter, Paul Wooley, Michael Optical Mechanical And Biochemical Characterization Heggeness Of Trabecular Bone Grazia Spatafora, Ilaria Bargigia, Markus Malo, Federico Poster No. 1480 Tortelli, Mohamad Shahgholi, Marco Agnoletto, Marco Co-delivery of Amniotic Membrane and BMP-2 for Domenicucci, Giuseppe M Peretti, Jeoffrey A Hubbell, Regeneration of Segmental Bone Defects Jukka S Jurvelin, Antonio Pifferi, Paola Taroni, Lauren B Priddy, Nikhil Gupte, Laxminarayanan Krishnan, Federica Boschetti Marian Hettiaratchi, Robert E Guldberg

Poster No. 1471 Poster No. 1481 The Changing Microarchitecture of Trabecular Characterization of Gene Expression in Bone During Compression BMP-2 Mediated Bone Regeneration Robert J Wallace, Krishna Manda, Erika Sales, Lauren B Priddy, Laxminarayanan Krishnan, Pankaj Pankaj, Hamish Simpson Hazel Y Stevens, Robert E Guldberg

Poster No. 1472 Poster No. 1482 Spatial Correlations Between Microdamage and Finite Age-related Differences in BMP-2-mediated Element Derived Local Tissue Strain in Cancellous Bone Bone Repair Matthew G Goff, Floor M Lambers, Rachel M Sorna, Tony M Albert Cheng, Laxminarayanan Krishnan, Lisa Tran, Keaveny, Christopher J Hernandez Robert E Guldberg

Poster No. 1473 Poster No. 1483 Fracture Response of Human Cortical Bone with Combinatorial Gene Therapy Accelerates Bone Reduced Compositional Heterogeneity Regeneration: Non-viral Dual Delivery Of VEGF And Alexandra Abel, Ani Ural BMP2 In A Collagen-nanohydroxyapatite Scaffold Erica Grace Tierney, Caroline M Curtin, Kevin McSorley, Poster No. 1474 Sally Ann Cryan, Garry P Duffy, Fergal J O’Brien Viscoelastic Creep Properties of Bone at Various Degrees of Mineralization Poster No. 1484 Gavriel Feuer, Subrata Saha BMP-2 Gene & Cell-functionalized 3D Scaffolds for the Repair of Cranial Bone Defect Poster No. 1475 Hang Lin, Ying Tang, Jingwen Xue, Weifeng Yin, Association between Reference Point Indentation Bing Wang, Rocky S Tuan Measures, Bone Composition, and Mechanical POSTERS Properties in Human Cortical Bone Poster No. 1485 Lamya Karim, Daniel J Brooks, Rachel Adams, Gregory Oligochitosan-pDNA Activated Collagen Scaffolds as a Dadourian, Garrett Easson, Mary L Bouxsein Platform For Bone and Cartilage Tissue Regeneration Rosanne M Raftery, Caroline M Curtin, Sally Ann Cryan, Poster No. 1476 Fergal J O’Brien A Multi-level Finite Element Analysis of Fluid/Solute Flow in Mechanically Loaded Bone Poster No. 1486 Lixia Fan, Xiaohan Lai, Shaopeng Pei, Liyun Wang An Injectable Complex Of Beta-Tricalcium Phosphate Granules, Hyaluronate, And RhFGF-2 On Repair Of Poster No. 1477 Long-Bone Fractures With Large Fragments Influence of Vascular Porosity Morphology on Takaaki Tanaka, Yoshio Kumagae, Masaaki Chazono, Loading-Induced Interstitial Fluid Flow in the Lacunar- Hirokazu Komaki, Seiichiro Kitasato, Atsuhito Kakuta, Canalicular Porosity of Estrogen-DeficientR ats Keishi Marumo Vittorio Gatti, Evan M. Azoulay, Luis Cardoso, Susannah P. Fritton Poster No. 1487 Extracellular Matrix Modification by Microsecond- Pulsed Dielectric Barrier Discharge Plasma Treatment Enhances Bone Formation Peter Eisenhauer, Qian-shi Zhang, Natalie Chernets, Theresa A Freeman 120 Poster No. 1488 Poster No. 1498 Bone Tissue Regeneration: Effect of Low Intensity Mesenchymal Stem Cells-derived Exosomes Promote Pulse Ultrasound on MC3T3 Cells in Bovine Trabecular Bone Repair In Mouse Model Bone Scaffold under Dynamic Flow Bioreactor Taisuke Furuta, Shigeru Miyaki, Hiroyuki Ishitobi, Naosuke Surinder S Moonga, Yi-Xian Qin Kamei, Mitsuo Ochi

Poster No. 1489 Poster No. 1499 Does Femoral Osteochondroplasty Restore Adequate Scleraxis Modulates Cortical Morphology Motion for All Athletes to Perform Their Sports And Fracture Healing without Bony Impingement Megan Leigh Killian, Adam C Abraham, Jennifer A Philip C Noble, Joshua Harris, Sabir Ismaily, McKenzie, Evan G Buettmann, Michael J Gardner, Matthew Jonathan E Gold J Silva

Poster No. 1490 PS2 Bone Fracture - Biomechanics/Clinical Vitamin D Status Interrelationship Of Bone Health And Fusion Consolidation Poster No. 1500 Ruben Maldonado, Mark T Svet, Linda E A Kanim, Study of Phalangeal Fracture Threshold and Design David Schultz, Melodie F Metzger of a Surrogate for Human Finger Ming Shen, Ariana Mostafa, Paul C Begeman, Poster No. 1491 Tal Saif, King H Yang In Vivo Heat-stimulus Triggered Osteogenesis Kunihiro Ikuta, Hiroshi Urakawa, Eiji Kozawa, Shunsuke Poster No. 1501 Hamada, Naoki Ishiguro, Yoshihiro Nishida Development Of A Novel Model System To Study Compressive Immature Rib Fractures Poster No. 1492 Nicola Beadle, Michael J Sherratt, Timothy L Burnett, Judith Test The Clinical Viability Of Chondrogenically Primed A Hoyland, Anthony J Freemont Pre-vascularised Cellular Aggregates Using An Subcutaneous In Vivo Rat Model Poster No. 1502 Fiona E Freeman, Ashley B Allen, Hazel Y Stevens, Are 3.5mm Plates and Screws Ideal Forearm Fixation? Robert E Guldberg, Laoise McNamara Biomechanical Analysis of Diaphyseal Forearm Refracture PS2 Bone Fracture - Biology Jeffrey Shub, Charles M Lawrie, Stephen M Quinnan, Shahrose Hussain, Loren Latta, Edward Milne Poster No. 1493 ESET Histone Methyltransferase Plays An Essential Poster No. 1503 Role In Fracture Healing Are Left and Right the Same? Contralateral Liu Yang, Jacques Hacquebord, Sean Haloman, Andrew Microstructural and Biomechanical Differences in Ghatan, Ning Li, Howard A Chansky Radius and Tibia Bin Zhou, Y. Eric Yu, Ji Wang, Zhengdong Zhang, Fernando Poster No. 1494 Rosete, Kyle Nishiyama, Elizabeth Shane, X. Edward Guo Impaired Fracture Healing Caused By Deficiency Of The Immunoreceptor Adaptor Protein DAP12 Poster No. 1504 Masayuki Kamimura Comprehensive Validations of HR-pQCT Based Morphological and Biomechanical Measures Poster No. 1495 of Human Distal Radius and Tibia Conditional Deletion of Runx3 in Prx-positive Cells Bin Zhou, Ji Wang, Y. Eric Yu, Zhendong Zhang, Ruoyu Resulted in Accelerated Fracture Healing Sheng, Alexander Wang, Kyle Nishiyama, Elizabeth Shane, David N. Paglia, Do Yu Soung, Jayne Gavrity, Vanessa X. Edward Guo Scanlon, Archana Sanjay, Hani Awad, Hicham Drissi Poster No. 1505

Poster No. 1496 The Transmission Of Whole Body Sinusoidal And POSTERS The Complement Receptor C5aR On Osteoblasts Has Stochastic Vibration Signals To Bone An Immune Modulatory Function In Fracture Healing Daniel L Miranda, Ruby Kandah, Adam Roy, Eugene Stephanie Baur, Anna Kovtun, Thorsten Schinke, Michael Goldfield, David Paydarfar, Brian Snyder, Melissa Putman Amling, Markus Huber-Lang, Anita Ignatius Poster No. 1506 Poster No. 1497 Three-dimensional Analyses of Proximal Humeral Interruption Of Glycosphingolipid Synthesis Fractures using Computed Tomography with Decelerates Endochondral Ossification Multiplanar Reconstruction: The Relationship In Fracture Healing between Preoperative Bone Quality and Results of Dausuke Momma, Masahiko Takahata, Yusuke Kameda, Osteosynthesis Tomohiro Shimizu, Norimasa Iwasaki Satoshi Ikemura, Koki Ueda, Taro Mawatari

121 Poster No. 1507 Poster No. 1517 Comparison of Stochastic Predictors and Trabecular WITHDRAWN Bone Score (TBS) in Predicting the Risk of Hip Fracture for Postmenopausal Women Poster No. 1518 Rajeshwar Pinninti, Patricia Cussen, Timothy Lowe, Anti-RANKL Treatment Improves Screw Fixation Joyce E Ballard, David Di Paolo, Mukul Shirvaikar, In Cancellous Bone In Rats Xuanliang Neil Dong Magnus Bernhardsson, Olof Sandberg, Per Aspenberg

Poster No. 1508 Poster No. 1519 Mechanism of Extremity Pathologic Fracture is Doxycycline Inducible Adenoviral Delivery Of Bmp- Different from Osteoporotic Fracture 2 With Mesenchymal Stem Cells And A Calcium Heli K. Shah, Kenneth A. Mann, Timothy A. Damron Phosphate Ceramic For The Repair Of Critically-sized Bone Defects In A Rat Model Poster No. 1509 Jennifer Bara, Dirk Nehrbass, David Eglin, Martina Anton, Multidirectional Poroelastic Ultrasound (PeUS)and Guy Daculsi, Mauro Alini, Martin Stoddart Fabric-Anisotropy Predict Elastic and Yield Mechanical Properties of Trabecular Bone Poster No. 1520 Paolo E Palacio-Mancheno, Sankha Ghatak, Promoting in vivo Osteogenesis using Lansoprazole Mohammad F Souzanchi, Stephen C Cowin, Luis Cardoso Kenichi Mishima, Hiroshi Sugiura, Masaki Matsushita, Hiroshi Kitoh, Naoki Ishiguro, Kinji Ohno Poster No. 1510 Structural Strength of Bovine Cancellous Cubic Poster No. 1521 Specimens Under Cyclic Compression The Masquelet Induced Membrane Technique with Kaori Endo, Satoshi Yamada, Masahiro Todoh, BMP and a Synthetic Scaffold Can Heal a Rat Shigeru Tadano, Masahiko Takahata, Norimasa Iwasaki Femoral Critical Size Defect Magnus Tagil, Per Bosemark, Christina Perdikouri, Poster No. 1511 Mea Pelkonen, Hanna Isaksson Optimizing Bone Grafting Procedures in Proximal Tibial Bone Grafting- A Biomechanical Study Poster No. 1522 Chin Tat Lim, David QK Ng, Wilson Wang, Ken Jin Tan, Large Autologous Bone Graft Augmented By Desmond YR Chong Mesenchymal Stromal Cell Or Fibroblast Growth Factor-2 Accelerates Bone Union In Rat Model Poster No. 1512 Hiroaki Murakami, Tomoyuki Nakasa, Mitsuo Ochi Mini Plate Can Influence the Primary Healing of a Long Bone Fracture Fixed with a Compression Plate Poster No. 1523 Jihui Li, Cary Schwartzbach, Ilia A Iliev, Ryan Westbrook, N-acetyl Cysteine (NAC) Restores Normal Onset of Mark Theiss Osteogenesis in a Fracture Model of Chronic Ethanol- Fed Rats PS2 Bone Fracture - Repair/Therapeutics Dennis A Chakkalakal, Geoffrey M Thiele, Anand Dusad, Michael J Duryee, Joseph D Bruenjes, Karen C Easterling, Poster No. 1513 Justin C Siebler Osthole, an Anabolic Small Molecule, Enhances Bone Regeneration in Fracture Healing Poster No. 1524 Zhongrong Zhang, Ho Yee Cheung, Wing Nang Leung, Local Administration of Non-diabetic hMSCs to Gang Li, Chun Wai Chan Diabetic Murine Femoral Fractures Enhances Callus Remodeling and Deposition of Reparative Bone POSTERS Poster No. 1514 Luke Watson, Xi Zhe Chen, Aideen E. Ryan, Paul G. Loftus, Stimulation of Osteoblast Differentiation and Timothy O’Brien, Cynthia M Coleman Increased Rate of Bone Defect Repair by a Novel Potent Lactam Acetylene EP4 Receptor Agonists Poster No. 1525 Stephen Barrett, Jim O’Malley, Gregory Endres, Adam Fibrin Gel And β-tcp Granules Loaded With Bmp-2 Uzieblo, Bradley Germain, Andrei Kornilov, Joseph Messenger Rna Lipoplexes For Local Gene Delivery Colombo, James Kramer, Liyue Huang, Jeffrey Johnson, Elizabeth Rosado Balmayor, Johannes-Peter Geiger, Ross Sanfilippo, Thomas A Owen Manish Kumar Aneja, Christian Koch, Carsten Rudolph, Christian Plank Poster No. 1515 Delayed Fracture Healing in a Mouse Model Poster No. 1526 of Saethre-Chotzen Syndrome Pre-Clinical Evaluation of the Local Delivery of Sharon L Hyzy, Gireesh B. Reddy, Rene Olivares-Navarrete, Rifamycins Against Staphylococcus aureus Biofilms Barbara D. Boyan, Zvi Schwartz Sharanda K Hardy, Kevin S Akers, Joseph C Wenke, Carlos J Sanchez Poster No. 1516 Profiling MicroRNA Expression in Fracture Healing in Poster No. 1527 Diabetic Rat Delivery of Osteoporosis Drugs From Mesoporous Shunsuke Takahara, Sang Yang Lee, Takahiro Niikura, Coatings and Bone Remodelling in Rat Models Takashi Iwakura, Etsuko Okumachi, Takahiro Waki, Michio Necati Harmankaya, Johan Karlsson, Anders Palmquist, 122 Arakura, Ryosuke Kuroda, Masahiro Kurosaka Mats Halvarsson, Martin Andersson, Pentti Tengvall Poster No. 1528 Poster No. 1538 Effect Of Dedifferentiated Fat Cell Transplantation Fabric-Microarchitecture Predicts Anisotropic Combined With Parathyroid Hormone Administration Elastic and Anisotropic Yield Shear Behavior of On Bone Formation In A Rat Nonunion Model Trabecular Bone Gouki Kinoshita, Shinsuke Kikuta, Tomohiko Kazama, Paolo E Palacio-Mancheno, Christina Moawad, Melvin Taro Matsumoto Mejia, Mohammad F Souzanchi, Stephen C Cowin, Luis Cardoso Poster No. 1529 The Effect of Teriparatide on Femoral Neck Fracture PS2 Spine - Computational Modeling Healing in Men and Postmenopausal Women Mohit Bhandari, Marc Swiontkowski, Ling Jin, Kyoungah Poster No. 1539 See, Russel T Burge, Kelly D Krohn, Margaret R Warner, Comparative Analysis on the Implications of Anterior Qasim I Ahmad, Bruce Mitlak Lumbar Interbody Fusion and Posterior Lumbar Interbody Fusion on Adjacent Segment Biomechanics: PS2 Bone Fracture - Mechanics and Computational a Finite Element Study Modeling Shihab Asfour, Shady Elmasry, Loren Latta, Joseph Gjolaj, Francesco Travascio, Frank Eismont Poster No. 1530 Finite Element Modeling of the Ovine Hindlimb Poster No. 1540 for the Investigation of Microgravity-Related Virtual Stress Testing of Pedicle Screws in a Large Mechanobiological Alterations Sample of Women Using Patient-Specific Finite Benjamin C Gadomski, Zachary F Lerner, Element Analysis Raymond C Browning, Christian M Puttlitz Tony Keaveny, Kwang Lee

Poster No. 1531 Poster No. 1540A QCT-Based Finite Element Models Do Not Accurately Variation in Lumbar Anatomy for Healthy and Predict Vertebral Failure Under Anterior Flexion Disc Degenerated Populations Timothy M Jackman, Elise F Morgan Justin F.M. Hollenbeck, Christopher M Cain, Jill Fattor, Clare K Fitzpatrick, Paul J Rullkoetter, Peter J Laz Poster No. 1532 Development of a Reference Database for Proximal Poster No. 1541 Femoral Strength in Men and Women Age 27 to 96 Effect Of Varying Geometrical And Material Properties Joyce H Keyak, Tadashi S Kaneko, Sundeep Khosla, And Fixation Techniques In Posterior Lumbar Spinal Shreyasee Amin Instrumentation On Spine Biomechanics: A Finite Element Study Poster No. 1533 Raghu N Natarajan, Kazuhiro Hasegawa Finite Element Representation of Bone-Screw Pull-Out Sean Hu, Dana J Coombs, Michael Bushelow, Andy Poster No. 1541A Freeman, P J Laz, Paul J Rullkoetter Validation of an Automated Method for Generating Subject-Specific Finite Element Models Poster No. 1534 of the Lumbar Spine Damage Mechanisms in Cortical Bone Julius Q Campbell, Paul J Rullkoetter, Anthony Petrella During RPI Testing Bryan Beutel, Matin Lendhey, Oran D Kennedy Poster No. 1542 Cervical Spinal Cord Stress: A Comprehensive Poster No. 1535 FE Model of the Cervical Spine and Cord How Much Trabecular Bone Damage Kirsten E Stoner, Kingsley Abode-Iyamah, Stephanus Is Induced By Screw Insertion? Viljoen, Douglas C Fredericks, Matthew Howard, Juri A Steiner, Harry G van Lenthe, Stephen J Ferguson Nicole Grosland

Poster No. 1536 Poster No. 1542A POSTERS Bone Fracture under Wedge Indentation in Bovine Lordotic Endplate Balancing Cages May Provide Cortical Bone with Finite Element Analysis Greater Stability than Non-balanced Cages in Posterior Kevin Hoffseth, Connor Randall, Srinivasan Chandrasekar, Lumbar Interbody Fusion: A Finite Element Study Paul Hansma, Henry T Yang Amanda Zakeri, Aakash Agarwal, Anand Agarwal, Vijay Goel Poster No. 1537 Trabecular Microarchicture Predicts Fabric Tensor and PS2 Spine - Scoliosis Anisotropic Mechanical Behavior of Trabecular Bone in Compression and Shear Poster No. 1543 Annalisa De Paolis, Stephen Cowin, Luis Cardoso Kinematic Comparison of the Osteo-ligamentous Adolescent Idiopathic Scoliosis Spine with the Normative: A Finite Element Modeling Study Prasannaah Hadagali, Aditya Belwadi, John P Dougherty, Sriram Balasubramanian

123 Poster No. 1544 Poster No. 1554 HSPG2 Variant Associated with 3D Angioarchitecture of Spinal Cord in a Rat Model Familial Idiopathic Scoliosis Detected by Synchrotron Radiation Micro-computed Erin E. Baschal, Cambria I Wethey, Kandice Swindle, Tomography (SR-MicroCT) Robin M Baschal, Katherine Gowan, Nelson L. S. Tang, Hongbin Lu, Yong Cao, Tianding Wu, Jianzhong Hu Matthew B Dobbs, Matthew R. G. Taylor, Christina A. Gurnett, Kenneth L. Jones, Nancy Hadley-Miller Poster No. 1555 Role Of Fgf18 In Motor Neurons Of The Spinal Cord Poster No. 1545 Kenyu Ito, Bisei Ohkawara, Shiro Imagama, Kinji Ohno, Stability Analysis of A Self-Adaptive Growing Naoki Ishiguro Rods System for Early Onset Scoliosis Frank Li, Po-Liang Lai, Andy Chien, Wen-Kai Chou, Poster No. 1556 Jaw-Lin Wang Validation of a Novel Animal Model of Thoracolumbar Burst Fracture-Induced Spinal Cord Injury - Poster No. 1546 The Impactor Study Phase Bone Metabolism And Trabecular Bone Micro- Rory Petteys, Steven Spitz, Rachel Sarabia-Estrada, Hasan architecture In Adolescent Idiopathic Scoliosis Syed, Robert Rice, Daniel Sciubba, Brett Freedman Hironori Tanabe, Yoichi Aota, Naoyuki Nakamura, Masafumi Machida, Tomoyuki Saito Poster No. 1557 Synergistic Neurogenic and Angiogenic Effects of Poster No. 1547 Combined Biologic (PTH, EGF & bFGF) and Analytical Method to Reduce Pedicle Exogenous Mesenchymal Stem Cell Therapy During Screw Complications Spinal Cord Hemisection Healing in a Murine Model Giovanni F Solitro, Farid Amirouche Qingqing Li, Hai Liu, Yu Chen, Longze Zhang, Guoyong Yin, Regis J O’Keefe, Edward M. Schwarz, Chao Xie Poster No. 1548 A Mouse Model of Scoliosis PS2 Spine - Disc Mechanics Xing-Ming Shi, Jun Zheng, Jay Cao, Nianlan Yang, Kehong Ding, Mark Hamrick, Carlos Isales Poster No. 1558 Net Transport Into the Degenerated Intervertebral Poster No. 1549 Disc Is Enhanced via Low Rate Loading Induced An Endplate-Based Joint Coordinate System for Convection In Vivo Measuring Kinematics in Normal and Abnormally Sarah Gullbrand, Jenna Ahlborn, Timothy Roberts, Shaped Lumbar Vertebrae Joseph Glennon, Mostafa Absousayed, David B Berry, Ana E Rodriguez-Soto, Jana R Tokunaga, James P Lawrence, Eric H Ledet Sara P Gombatto, Samuel R Ward Poster No. 1559 Poster No. 1550 Spectroscopic Analysis of Human Endplate Cartilage: A Novel Surface Reconstruction Method for Comparison to Articular Cartilage and Correlation with the Deformed Thoracic Cage Using Biplanar Biomechanical Properties Projections and 3D Statistical Priors Aaron J Fields, Harsh Goel, Deanna Necula, Jeffrey C. Lotz, James R Peters, Sriram Balasubramanian Galateia J. Kazakia

PS2 Spine - Peripheral Nerve and Spinal Cord Injury Poster No. 1560 Is Cervical Sagittal Imbalance an Independent Poster No. 1551 Risk Factor for Adjacent Segment Disease After POSTERS Effect of Bone Fragment Impact Velocity by Multilevel Fusion? Burst Fracture on Biomechanical Parameters Avinash G Patwardhan, Saeed Khayatzadeh, Ngoc-Lam Associated to Spinal Cord Injury Nguyen, Robert M Havey, Leonard I. Voronov, muturi Batbayar Khuyagbaatar, Kyungsoo Kim, Yoon Hyuk Kim muriuki, Gerard Carandang, Alexander J. Ghanayem, Alpesh A. Patel, Zachary A. Smith, William Sears Poster No. 1552 Dislocation Spinal Cord Injury in a Rodent Poster No. 1561 Model - Identifying Variability using In Vivo Deformation Of L4-5 And L5-s1 Discs During High-Speed X-Ray Imaging A Weight-lifting Extension Thomas Oxland Zhan Liu, Minfei Wu, Sean Driscoll, Shaobai Wang, Tsung- Yuan Tsai, Thomas D Cha, Kirkham B Wood, Guoan Li Poster No. 1553 Transcription Factor Decoy NFκΒ Inhibits the Poster No. 1562 Expression of Cytokines and Pain Markers in Rat Mr Diffusion Is Sensitive To Mechanical Loading In Dorsal Root Ganglion Organ Cultures Human Intervertebral Discs Shintaro Shoju, Mary Lenz, Sameer B. Shah, Mitsuru Naiki, Ron N Alkalay, Carl-Fredrik Westin, David Hackney Koichi Masuda

124 Poster No. 1563 Poster No. 1572 Time-dependent Biomechanical Behaviour of a Anterior Cervical Discectomy And Fusion (ACDF): Hydrogel-based Disc Arthroplasty Comparison Between Zero Profile Implants And Weng-Pin Chen, Chien-Yu Lin, Shih-Youeng Chuang, Yang- Anterior Cervical Plate And Spacer Hwei Tsuang, Chang-Jung Chiang Marjan Alimi, Innocent Njoku, Christoph Hofstetter, Kartik Kesavabhotla, Apostolos J Tsiouris, John Boockvar, Roger Poster No. 1564 Hartl DiffusionT ensor Imaging Detects The Spatial Variation In Fiber Angle and Lamellar Number PS2 Spine - Spine Therapeutics (In vivo Preclinical) In Intact Human Disc Joint Ron N Alkalay, Carl-Fredrik Westin, Dominik Meier, Poster No. 1573 David B Hackney A Novel AAV Vector-based Combinatorial Gene Therapy Ameliorates Spine Abnormalities in a Severe PS2 Spine - Spine Therapeutics (Clinical) DMD Murine Model Robert Kang, Ying Tang, Qing Dong, Kara Imbrogno, Poster No. 1565 Qing Yang, James Kang, Bing Wang Anatomical Analysis of Artery Variations for the Lower Lumbar Spine Poster No. 1574 Toshinori Sakai, Fumitake Tezuka, Toshihiko Nishisho, Pre-operative Lumbar Axial Rotation in Disc Yoichiro Takata, Kosaku Higashino, Shoichiro Takao, Herniation Patients Predicts Post-operative Low Masafumi Harada, Koichi Sairyo Back Pain Kresten Rickers, Sayuri Kitahata, Alejandro A Espinoza Poster No. 1566 Orias, Steffen Ringgaard, Finn B Christensen, Gunnar BJ Severity of Stenosis Correlation Using MRI, Dural Cross Andersson, Cody E. Bünger, Jenna Peterson, Haisheng Li, Sectional Area and Owestry Disability Index Nozomu Inoue, Bruce Robie Satyajit Marawar, Mark Palumbo, Richard A Tallarico, Ian Madom, Dongliang Wang, Nathaniel R Ordway, Poster No. 1575 William F Lavelle Teriparatide Improves Trabecular Osteoporosis but Simultaneously Promotes Spinal Ankylosis in Poster No. 1567 the twy Mice Model for Diffuse Idiopathic Skeletal Three-dimensional Analysis of the Occipital Condyle Hyperostosis Considering the Internal Hypoglossal Canal Structure Hiroki Hamano, Masahiko Takahata, Masahiro Ota, Jinsong Zhou, Alejandro A Espinoza Orias, Howard S An, Shigeto Hiratsuka, Tomohiro Shimizu, Yusuke Kameda, Nozomu Inoue Norimasa Iwasaki

Poster No. 1568 Poster No. 1576 Targeted Therapy of Low Back Pain Associated with Comparison Of A Novel Porous Titanium-Nickel de novo Degenerative Lumbar Scoliosis in the Elderly: Intervertebral Fusion Device And A Poly-ether-ether- Observation Cohort Study ketone Intervertebral Fusion Device In A Sheep Toshio Nakamae, Yoshinori Fujimoto, Kiyotaka Yamada, Lumbar Fusion Study Osami Suzuki, Takashi Hashimoto, Masaki Matsuura, Carl Lauryssen, Gary S Fanton, EJ Ehrhart, Dana Ruehlman, Taiki Morisako Howard Seim, Jeremiah T Easley

Poster No. 1569 Poster No. 1577 Characteristics of Postural Control Dynamics in Nell-1 Promotes Spinal Fusion In Non-human Primates Patients with Cervical Spondylotic Myelopathy after Jia Shen, Aaron W James, Kevork Khadarian, Weiming Li, Surgery and Post-Surgery Exercise Training Jinny Kwak, Min Lee, Benjamin Wu, Kang Ting, Chia Soo, Chih-Hsiu Cheng, Hao-Tsung Su, Jaw-Lin Wang, Xinli Zhang Dar-Ming Lai, Shwu-Fen Wang, Wei-Li Hsu, Yu-Lin Chang, Hui-Chu Chung PS2 Spine - Disc, Tissue Engineering and Repair POSTERS Poster No. 1570 Poster No. 1578 The Relationship Between Transversus Abdominis A Novel in Vitro Model of the Annulus and Lumbar Multifidus During the Lifting Task Fibrosus-Cartilage Endplate Interface Takuya Miura, Masanori Yamanaka, Yasuhiro Morii, Hiroshi Elisabeth Rok, Marc Grynpas, J Paul Santerre, Rita Kandel Saito, Mina Samukawa, Takumi Kobayashi, Takumi Ino, Harukazu Tohyama Poster No. 1579 Visualization of Collagen Crimp in Multilayer Annulus Poster No. 1571 Fibrosus using Ultra-High Field 9.4T MRI WITHDRAWN Scott Moorman, Jeff Dunn, John Matyas, Neil Duncan

Poster No. 1580 E ffects of Depth of Annular Injury and Tumor Necrosis Factor-alpha on Disc Degeneration and Pain Alon Lai, Andrew Moon, Devina Purmessur, Branko Skovrlj, Beth Winkelstein, Samuel Cho, Andrew C Hecht, James C Iatridis 125 Poster No. 1581 Poster No. 1591 Fibrin-Genipin Annulus Fibrosus Sealant Genipin-Crosslinked Gelatin Hydrogel Injection as a Delivery System for Anti-TNFκ Drug Recovers the Functional Integrity of Intervertebral Morakot Likhitpanichkul, Yesul Kim, Eugene See, Disc Secondary to a Needle Puncture: An in vitro Olivia M Torre, Zepur Kazezian, Abhay Pandit, Porcine Model Using Quantitative Andrew C Hecht, James C Iatridis Discomanometry Examination Jui-Jung Yang, Wen-Kai Chou, Andy Chien, Jaw-Lin Wang Poster No. 1582 Structural, Chemical and Cellular Enhancements Poster No. 1592 to Improve Adhesive and Bulk properties of Fibrin- Sustained Cellular, Structural, and Mechanical Genipin in Sealing the Annulus Fibrosus Integrity of Murine Functional Spine Units in Michelle A Cruz, Svenja Illien-Junger, David Eglin, Controlled Culture Andrew C Hecht, James C Iatridis Adam C Abraham, Jennifer W Liu, Simon Tang

Poster No. 1583 PS2 Spine - Disc Biology Fibrin Based Annular Sealant Has Low Risk of Herniation in Bending in Bovine IVD Injury Model Poster No. 1593 Rose G Long, Diana C Litsas, David Eglin, Sebastien B Follistatin-like Protein 1 Attenuates Catabolic Effects Blanquer, Dirk W Grijpma, Andrew C Hecht, Of Tumor Necrosis Factor-κ (TNF-κ) Through Nuclear James C Iatridis Factor κB (NF-ΚB) Signaling In Notochordal Cells Ryuichi Watanabe, Nobuyuki Fujita, Satoshi Suzuki, Poster No. 1584 Tomohiro Hikata, Kota Watanabe, Ken Ishii, Keisuke Effect Of A Selective Inhibitor Of c-Fos/activator Horiuchi, Takeshi Miyamoto, Yoshiaki Toyama, Protein-1 On Intervertebral Disc Degeneration Morio Matsumoto Induced By Needle Puncture In Rats Hiroto Makino, Shoji Seki, Hiraku Motomura, Poster No. 1594 Yasuhito Yahara, Makiko Nogami, Shunichi Shiozawa, Cadherin 2 Is Essential To Tie2+ Notochordal Cell Tomoatsu Kimura Maintenance In Nucleus Pulposus Foonlian Lim, Wai-Kit Tam, Changli Zhang, Tiffany YL Au, Poster No. 1585 Danny Chan, Kathryn S Cheah, Rocky Tuan, Kenneth M Dynamic Loading Improves Intervertebral Disc Cheung, Victor YL Leung Metabolic Activity And Nutrient Exchange Under Low Glucose Conditions Poster No. 1595 Derek Rosenzweig, janet Moir, Thomas Steffen, Glucose Consumption Rate of Notochordal Nucleus Lisbet Haglund Pulposus Cells Following Prolonged Exposure to Various Nutrient Concentrations Poster No. 1586 Lukas M Jaworski, Kelsey L Kleinhans, Alicia Jackson Small-molecule Suppressors of Proteoglycan Catabolism in Degenerative Disc Cells Poster No. 1596 Yi Sun, Koichi Masuda, Danny Chan, Kenneth Cheung, Assessing The Effect of Notochord-specific Deletion Victor Leung of Ccn2 on Intervertebral Disc Degeneration and Behavior Associated with Back Pain Poster No. 1587 Jake Bedore, Sunny Jang, Matthew Veras, Developing a Minimally Invasive Nucleus Replacement Amanda Sauvé, Andrew Leask, Cheryle Séguin Procedure Using High Intensity Focussed Ultrasound (HIFU): Effect of Hyperthermia on Collagen Integrity Poster No. 1597 POSTERS and Cell Viability in the Intervertebral Disc Is There A True Nucleus Pulpous Marker Which Can Be Olga A Boubriak, Jill P.G. Urban, Delphine Elbes, Shan Qiao, Used To Determine Stem Cell Differentiation Towards A Robin O. Cleveland, Constantin Coussios Nucleus Pulposus Phenotype Rather Than Chondrocytes? Poster No. 1588 Abbey A Thorpe, Laura Creemers, Ashley A Cole, Effect of Scaffold Density and Crosslinking on Alginate Lee M Breakwell, Antony L R Michael, Neil Chiverton, and Collagen Tissue-Engineered Intervertebral Discs Chris Sammon, Christine L Le Maitre Jorge A Mojica-Santiago, Yu Moriguchi, Peter Grunert, Roger Hartl, Lawrence J Bonassar Poster No. 1598 Role of Collagen Substrate Configuration and Poster No. 1589 Stiffness on Nucleus Pulposus Cell Morphology WITHDRAWN Lauren Resutek, Hyunchul Kim, Adam H Hsieh

Poster No. 1590 Poster No. 1599 Methacrylated Gelatin Hydrogel in Intervertebral Effects of Adenosine Treatment on Extracellular Matrix Disc Tissue Engineering Biosynthesis and Intracellular ATP Production in Karl Henrikson, Pedro Pohl, Hang Lin, Gwendolyn Sowa, Intervertebral Disc Cells Rocky Tuan, James D Kang Silvia D Gonzales, Chong Wang, Carlos Barrera, Brittany Rodriguez, Chun-Yuh Huang

126 Poster No. 1600 Poster No. 1610 Advanced Glycation Endproducts induce Effects of Diurnal Loading on Interverterbral Disc Hypertrophy and Osteogenic Differentiation using a Whole Organ In vitro Culture Model in Nucleus Pulposus Cells James T Stannard, Aaron Stoker, Ferris Pfeiffer, Svenja Illien-Junger, Alexander Real, Olivia Torre, Theodore Choma, James L Cook William Kindschuh, Sheeraz A Qureshi, Andrew C Hecht, James C Iatridis Poster No. 1611 Intervertebral Disc Degeneration following Poster No. 1601 Impact Injury - A Rat Ex Vivo Model RANK/RANKL/OPG System in the Rat Fuxin Wei, Christopher T. Chen Intervertebral Disc Norihiko Takegami, Koji Akeda, Koichiro Murata, Poster No. 1612 Junichi Yamada, Akihiro Sudo A Biomechanical Model Simulating Vertebral Compression Fracture and Proximal Junctional Poster No. 1602 Kyphosis The Contribution Of ANKH, ENPP1 And TNAP Robin Parrish, William Camisa, Jeremi Leasure, On The Mineralization Of Nucleus Pulposus Jon Park, Christopher Ames Agata K Krzyzanowska, Robert Frawley, Sheela Damle, Tony Chen, Miguel Otero, Matthew Cunningham PS2 Spine - Mechanics

Poster No. 1603 Poster No. 1613 The Expression of Adiponectin Receptor Biomechanical Stability of the Metastatic Spine 1 and 2 of Rat Intervertebral Disc Cells Post-treatment with Bone-targeted Radiofrequency Yoshiki Terashima, Kenichiro Kakutani, Koichiro Maeno, Ablation (RFA) Alone and in Combination with Toru Takada, Takashi Yurube, Takuto Kurakawa, Shingo Percutaneous Vertebroplasty (PVP) Miyazaki, Masaaki Ito, Masahiro Kurosaka, Kotaro Nishida Padina S Pezeshki, Sean RH Davidson, Margarete Akens, Claire C McCann, Kieran Murphy, Michael Sherar, Poster No. 1604 Albert J Yee, Cari Whyne The Effect Of Recombinant Human Sirt1 On Apoptosis And Autophagy Of Human Nucleus Pulposus Cell Poster No. 1614 With Low Nutritional Condition Vertebral Body Response to Elevated Shingo Miyazaki, Kenichiro Kakutani, Koichiro Maeno, Frequency Fatigue Loading Toru Takada, Zhongying Zhang, Takashi Yurube, Takuto Rebecca Chung, Kaitlynn Pugliese, Gabrielle Vandergaag, Kurakawa, Yoshiki Terashima, Masaaki Ito, Koki Uno, Teppei Arthur Ritter, Antonio Valdevit Suzuki, Masahiro Kurosaka, Kotaro Nishida Poster No. 1615 Poster No. 1605 Analysis of Failures after Three Column Gene Expression of Notochordal Nucleus Osteotomies of the Spine Pulposus Cells Following Prolonged Culture Niranjan Kavadi, Richard A Tallarico, Mike Sun, at Varied Nutrient Levels William F Lavelle Lukas M Jaworski, Kelsey L Kleinhans, Alicia Jackson Poster No. 1616 Poster No. 1606 Relationship Between Material and Mechanical Is Acidic pH The Initiator For The Aberrant Nucleus Properties of Osteophytes and Non-osteophytic Pulposus Cell Function Observed In Intervertebral Cortical Bone: A Preliminary Study Disc Degeneration? Fred Xavier, rozan winter, martin pendola, Gavriel Feuer, Hamish T Gilbert, Nathan Hodson, Stephen M Richardson, Westley Hayes, Subrata Saha Judith A Hoyland Poster No. 1617 Poster No. 1607 The Effect of Vertebral Body Geometry on Pedicle

Alterations in Intervertebral Disc Matrix Homeostasis Screw Fixation Biomechanics in Human Lumbar Spine POSTERS in the UCD-T2DM Rat Model of Type 2 Diabetes Ata M Kiapour, Laura E Buckenmeyer, Kristophe J Karami, Aaron J. Fields, Stephanie Miller, Lionel N Metz, James L Vijay K Goel, Teck M Soo, Constantine K Demetropoulos Graham, Peter J Havel, Jeffrey C Lotz Poster No. 1618 Poster No. 1608 WITHDRAWN WITHDRAWN Poster No. 1619 Poster No. 1609 The Degenerative State Of The Intervertebral Disc Effects of Static Loading on Interverterbral Disc using a Independently Predicts The Failure Of Osteoporotic Whole Organ In vitro Culture Model Human Lumbar Spines Under High Rate Loading James T Stannard, Aaron Stoker, Alexis Zallas, Ferris Simulating A Backward Fall Event Pfeiffer, Theodore Choma, James Cook Ron N Alkalay, David Hackney

127 Poster No. 1620 Poster No. 1629 Improvement in Physical Performance in Patients with Laminar Thickness: Correlation Against Degenerative Facet Osteoarthropathy Lumbosacral Symptoms of Spinal Stenosis and Changes with Age Spine following Paravertebral Facet Injection Hamed Shalikar, Sean L Borkowski, Juan Pablo Villablanca, Tzu-Chuan Yen, Nima Toosizadeh, Michael Dohm, Sophia N Sangiorgio, Edward Ebramzadeh, Arya N Shamie Cindy Fastje, Bijan Najafi PS2 Knee - Kinematics and Gait Poster No. 1621 In-vivo Dynamic Changes of Dimensions Poster No. 1630 in the Lumbar Intervertebral Foramen A Low-Cost Multi-Sensor Device for Unsupervised Weiye Zhong, Sean Driscoll, Tsung-Yuan Tsai, Large Animal Activity Monitoring Shaobai Wang, Jing-Sheng Li, Zhan Liu, Thomas D Cha, Feini Qu, Peter M Gebhard, Christian G Pfeifer, Kirkham B Wood, Guoan Li Emily L Miedel, Robert L Mauck

Poster No. 1622 Poster No. 1631 Biomechanical Analysis of the Intact Sacroiliac Joint The Influence of Bony Landmark Identification on Following Posterior Ligament Injury Combined with Knee Kinematics Using Point Cluster Technique: Rigid Instrumentation and the Influence of Unilateral An In Vivo 3D-CT Study and Bilateral SIJ Screws Takumi Ino, Harukazu Tohyama, Kensaku Kawakami, Bruce E. Dall, Noel Goldthwaite, Sonia Eden, Toshinori Yoshida, Yuhei Ohsumi, Satoshi Kotake, Sho’ji Mark Moldavsky, Soumya Yandamuri, Brandon Bucklen Suzuki, Tatsunori Maeda, Kou Suzuki, Yasumitsu Ohkoshi

Poster No. 1623 Poster No. 1632 Regional Biomechanical Variations within The Center of Axial Rotation of the Femorotibial Joint the Vertebral Body Under Fatigue Loading in Osteoarthritic Knees - Medial Pivot vs Lateral Pivot - in Sagittal Plane Takumi Ino, Kensaku Kawakami, Satoshi Kotake, Yuuhei Constance Maglaras, Emily Noonan, Ohsumi, Toshinori Yoshida, Sho’ji Suzuki, Tatsunori Maeda, Arthur Ritter, Antonio Valdevit Kou Suzuki, Yasumitsu Ohkoshi

Poster No. 1624 Poster No. 1633 Interpedicular Kinematics in an In Vitro A Novel Volumetric-Data Based 2D to 3D Image Biomechanical Assessment of a Bilateral Registration Method Using MRI Scan Data and Lumbar Spondylolytic Defect Radiography Uphar Chamoli, Alan S Chen, Ashish D Diwan Koichi Kobayashi, Makoto Sakamoto, Yuji Tanabe, Takashi Sato, Go Omori, Yoshio Koga Poster No. 1625 Increase in Stability by Design Parameter Change in Poster No. 1634 Stand-alone Cage for Direct Lateral Interbody Fusion The Center of Axial Rotation during Walking in Yong Woo Kim, Won Man Park, Dae Kyung Choi, Kyungsoo the Anterior Cruciate Ligament-Deficient Knees Kim, Yoon Hyuk Kim Yuhei Ohsumi, Yasumitsu Ohkoshi, Kensaku Kawakami, Takumi Ino, Tatsunori Maeda, Ko Suzuki, Satoshi Kotake, Poster No. 1626 Kengo Ukishiro, Toshinori Yoshida, Sho’ji Suzuki, Facet Stabilization for Lumbar Posterior Harukazu Tohyama Stability- Facet Screw Versus Facet Spacer Ching-Lung Tai, Wen-Huang Liang, Po-Liang Lai Poster No. 1635 High Accuracy of Joint Kinetics Prediction in Lower POSTERS PS2 Spine - Biology Extremity with Wearable Sensor System during Walking Consistent to Optical Motion Capture System Poster No. 1627 with Force Plates Enrichment Of Committed, Chondroitin Sulfate- Tsolmonbaatar Khurelbaatar, Ariunzaya Dorj, expressing Human Nucleus Pulposus Cells Over Kyungsoo Kim, Yoon Hyuk Kim, Moonkee E Kim Progenitors Under Alginate Encapsulation Yi Sun, Minmin Lv, Zhaomin Zheng, Danny Chan, Poster No. 1636 Kenneth Cheung, Victor Leung Kinematic Accuracy of CT-Based and MRI-Based Bone Models for Model-Based Tracking When Using Biplanar Poster No. 1628 Videoradiography to Measure Knee Joint Kinematics Neuropeptide Y And Fear Avoidance Beliefs Emily R Robbins, Tarpit K Patel, Michael J Rainbow, Are Associated With Self-Reported Disability Braden C Fleming In Acute Low Back Pain Patients Gwendolyn Sowa, Wan Huang, Alhaji Buhari, Michael Poster No. 1637 Schneider Kinematics of Varus Thrust during Stepping Activity: a Pilot Study using a 3D-to-2D Registration Technique Kenji Hoshi, Goro Watanabe, Chikane Fujihira, Ryuji Tanaka, Yasuo Kurose, Jiro Fujii, Kazuyoshi Gamada

128 Poster No. 1638 Poster No. 1648 Three-dimensional In Vivo Motion Analysis of Anterior Comparison Between Parameterisation And Principle Cruciate Ligament Deficient Knees Using Single-plane Component Analysis In The Classification Of Fluoroscopy: Comparison to Contralateral Uninjured Osteoarthritic Gait Knees and Normal Control Knees Paul R Biggs, David Williams, Catherine A Holt, Takayuki Murayama, Takashi Sato, Satoshi Watanabe, Gemma M Whatling Osamu Tanifuji, Koichi Kobayashi, Tomoharu Mochizuki, Hiroshi Yamagiwa, Yoshio Koga, Go Omori, Naoto Endo Poster No. 1649 Three-Dimensional Knee Joint Kinematics in Obese Poster No. 1639 Individuals with Knee Pain during Treadmill Gait Axial Rotation Center of the Knee Changes Jing-Sheng Li, Tsung-Yuan Tsai, Katie Brentzel, Yoo Jin Ahn, along the Flexion-Extension Path David T Felson, Guoan Li, Cara L Lewis Yong Feng, Tsung-Yuan Tsai, Jing-Sheng Li, Shaobai Wang, Hai Hu, Changqing Zhang, Harry E Rubash, Guoan Li PS2 Knee - Mechanics

Poster No. 1640 Poster No. 1650 The Effects of Foot Orthoses on Sagittal Preliminary Evidence Supporting Shared Plane Energetics in Lower Extremity during Mechanical Abnormalities In ACL-Deficient Single-leg Landing Human And Ovine Knees Yu Ito, Masanori Yamanaka, Hisashi Matsumoto, Jillian E Beveridge, Christopher Bhatla, Gulshan Sharma, Tomoya Ishida, Yoshimitsu Aoki Gregor Kuntze, Nigel G Shrive, Cyril B Frank, Janet L Ronsky

Poster No. 1641 Poster No. 1651 Comparison Of Gait Biomechanics Between Accuracy And Efficacy Of Patient-specific Kinematically Aligned And Neutrally Aligned Instrumentations For Total Knee Arthroplasty: Total Knee Arthroplasty Analyses Of Three Different Systems Takeo Nagura, Yasuo Niki, Kengo Harato, Yoshiaki Toyama, Claudio Belvedere, Michele d’Amato, Paolo Barbadoro, Yasunori Suda Alessandro Feliciangeli, Alberto Leardini, Sandro Giannini, Andrea Ensini Poster No. 1642 Low-Cost Motion Capture: A Comparison to Vicon Poster No. 1652 Julia K Nichols, Mark P Sena, Oliver M. O’Reilly, Sex Differences in Knee Flexion Angle During Brian T Feeley, Jeffrey C Lotz a Rapid Change of Direction While Running Christopher L Sheu, David Brown, Aaron M. Gray, Poster No. 1643 Brian A. Smith Quantification of Rolling and Sliding in the Knee during Passive Flexion Motion using Bi-Plane Poster No. 1653 Fluoroscopic System The Effect of Malrotation of the Tibial Component of Cong-Bo Phan, Ho-Jung Jung, Seungbum Koo Total Knee Arthroplasty on the Tibial Insert Comparing Different Prosthesis: A Finite Element Analysis Poster No. 1644 Kei Osano, Ryuji Nagamine, Mitsugu Todo, Reduction in Muscle Co-contraction during Walking Makoto Kawasaki after Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis Poster No. 1654 Ariunzaya Dorj, Kyungsoo Kim, Kyung Wook Nha, An Investigation of the Relationship between Yoon Hyuk Kim, Moonkee Eric Kim Plantar Weight Distribution and the Condition of Osteoarthritic Knees During Quiet Standing Poster No. 1645 Brian Sutterer, Eric Reyes, Michael E Berend, Scott Small, Impact of Tibia Bearing Surface and Femoral Renee D Rogge Component Design on Flexion Kinematics

during Lunge Poster No. 1655 POSTERS Eik Siggelkow, Nick Drury, Iris Sauerberg, Marc Bandi Contralateral Knee Joint Contact Pressure after Unicondylar Knee Arthroplasty Poster No. 1646 Roy Rusly, Julia Lee, Michael Stokes, Xin Xie, Kyle Walker, A Gait Analysis and Proprioception Assessment Brandon Broome, Stephanie Tanner, John D DesJardins of Patients with Knee-sparing Massive Bone Tumour Implants Poster No. 1656 R Poursaeidi, M Coathup, M Thornton, I McCarthy, K Shah, Where Is The Appropriate Proximal Reference Point J Bhamra, P Unwin, G Blunn Of The Tibia In Total Knee Arthroplasty? Kenichiro Takashiba, Gen Uehara, Ryuji Nagamine Poster No. 1647 Differences In Knee Mechanics Between Customized, Individually Made BKR And Off-the-shelf TKR Patients During Walking Henry Wang, Jonathan Foster, Natasha Francksen, Jill Estes, Lindsey Rolston 129 PS2 Knee - Computational Modeling Poster No. 1666 Poplitues Tendon and Popliteofibular Ligament Are Poster No. 1657 Indispensable for More Reliable Computational Knee Integrated Modeling and Sensitivity Analysis Identify Joint Models Critical Parameters Associated with Subject-specific Tserenchimed Purevsuren, Kyungsoo Kim, Yoon Hyuk Kim Knee Function: Applications in ACL Injury and Reconstruction Poster No. 1667 Mohammad Kia, Kevin Schafer, Kyle Stone, Joseph Lipman, Effect Of Partial Meniscectomy On Cartilage Shear Anil Ranawat, Daniel Green, Michael Cross, David J Stress: Walking Versus Running Mayman, Andrew D Pearle, Thomas Wickiewicz, Diagarajen Carpanen, Robert Walker, Howard Hillstrom, Timothy Wright, Thomas Santner, Carl W Imhauser Franziska Reisse, Matthew F Koff, Mark Lenhoff, Rajshree Mootanah Poster No. 1658 Variation in Knee Shape Predicts the Future Onset PS2 Knee - Surgical Repair and Rehabilitation of Radiographic Knee Osteoarthritis (RKOA) and this Variation is Different in Males Compared to Females Poster No. 1668 Daniel P Nicolella, Todd L Bredbenner, Lorena Havill, Femoral Bowing is Main Determinant of the Proper Jose Tamez-Pena, Patricia Gonzalez, Ed Schreyer, Saara Alignment to Restore Mechanical Axis in Total Knee Totterman, C. Kent Kwoh Arthroplasty Philip C Noble, Sabir Ismaily, Gregory Stocks, Poster No. 1659 Romy Megahed Knee Bone Shape Features Predict The Progression Of Cartilage T1ρ 1 Year After ACL Reconstruction Poster No. 1669 Valentina Pedoia, Favian Su, Drew Lansdown, Musa Zaid, Rigid vs. Flexible Screwdriver for Femoral Interference Richard Souza, C Benjamin Ma, Xiaojuan Li Screw Placement: Comparison of Divergence and Fixation Strength Poster No. 1660 Mark E Steiner, Kempland C. Walley, Aidin Masoudi, Specimen-Specific Validation of Patellofemoral Joint Ohan S. Manoukian, Miguel E Perez-Viloria, Stephen Mechanics in a Finite Element Model of the Knee Okajima, Jeffrey Spalazzi, Araz Chiloyan, Maria Drazek, Azhar Ali, Adam J Cyr, Michael Harris, Sami Shalhoub, David W Wing, Ara Nazarian Clare K Fitzpatrick, Paul J Rullkoetter, Kevin B Shelburne Poster No. 1670 Poster No. 1661 Virtual Bone Analysis Determines Quantitative Assessment of Asymmetric and Metaphyseal Augment Fit Symmetric Tibial Baseplate Design with the Evan leibowitz, Daniel Lipschutz, Mohamed Soliman, Virtual Surgery Technique R. Michael Meneghini Jae Won Kim, Oui Sik Yoo, Jung Sung Kim, Doo Hun Sun, Yong Sik Kim Poster No. 1671 Load To Failure At The Femoral Cortex Using Transtibial Poster No. 1662 Versus Anteromedial Based ACL Tunnel Positions In Ligament Resting Length: A Method for Patient Human Cadaveric Specimens SpecificD etermination Michael J Feldstein, Thomas E Stephens, Alexis B.C. Dang Antonis Stylianou, Swithin Razu, Hamidreza Jahandar, Katherine H Bloemker, Akin Cil, Trent Guess Poster No. 1672 Biomechanical Comparison of Screw and Spiked Poster No. 1663 Washer versus Suture-Post for Tibial Sided Fixation in POSTERS The Effect of Patellar Height on Patellofemoral ACL Reconstruction Contact Pressure and Area after Medial Patellofemoral Dean Wang, Daniel V Boguszewski, Nirav B Joshi, Keith L Ligament Reconstruction: A Finite Element Analysis Markolf, Frank A Petrigliano, David R McAllister Nicole A DeVries Watson, Matthew J Bollier, Nicole M Grosland Poster No. 1673 Fabrication and Function of a Passive, Wireless Force Poster No. 1664 Sensor for Orthopedic Implants Trochlear Groove Geometry Prior To And After Total John F Drazan, Aleksandra A. Gunko, Omar T Abdoun, Knee Arthroplasty - Are The Preoperative Conditions Reena Dahle, Nathaniel C Cady, Kenneth A Connor, Restorable? Eric H Ledet Enrico Mick, Joerg Luetzner, Stephan Kirschner, Richard Bieck, Robert Souffrant, Rainer Bader Poster No. 1674 Relationship of the Posterior Femoral Axis of the Poster No. 1665 “Kinematically Aligned” Total Knee Arthroplasty Importance of Inhomogeneous Elastic Properties of to the Posterior Condylar, Transepicondylar, and Bone on Mechanical Responses of Articular Cartilage Anteroposterior Femoral Axes in Human Knee Joint - Combination of CT Imaging and Denis Nam, Andrew Park, Stephen Duncan, Computational Modeling Ryan Nunley, James Keeney, Robert L Barrack Mikko S Venäläinen, Mika E Mononen, Jukka S Jurvelin, Juha Töyräs, Tuomas Viren, Rami K Korhonen 130 Poster No. 1675 Poster No. 1685 3D Analysis of Uniplanar and Biplanar Opening- Influences Of Knee Flexion Angle And Portal Position Wedge High Tibial Osteotomies On The Location Of Femoral Tunnel Outlet In Anterior Gareth G Jones, Martin Jaere, Anthony Leong, Cruciate Ligament Reconstruction Rory McMillan, Justin Cobb Kanji Osaki, Ken Okazaki, Hideki Mizu-uchi, Satoshi Hamai, Umito Kuwashima, Koji Murakami, Yukihide Iwamoto Poster No. 1676 Measurement Of Soft Tissue Balance In Tka With Poster No. 1686 Preoperative Flexion Contracture Does Pre-surgical Treatment Affect Joint Loading and Masato Aratake, Naoto Mitsugi, Naoya Taki, Hirohiko Ota, Motion Five years after ACL-Reconstruction? Kentaro Shinohara Zakariya H Nawasreh, Adam Marmon, David Logerstedt, Lynn Snyder-Mackler Poster No. 1677 A Cortical Suspension Technique for Distal Pole Patella Poster No. 1687 Tendon Repair: Biomechanical Evaluation Versus Effect Of Graft Inclination Angle In Single Bundle Transosseous Tunnel Suture Repair and Suture Anchor Anterior Cruciate Ligament Reconstruction On Knee Repair Techniques Kinematics Gabriella Ode, Dana Piasecki, Nahir Habet, Richard Peindl Paulo H Araujo, Shigehiro Asai, Mauricio Pinto, Thiago Protta, Kellie K Middleton, James J Irrgang, Monica Linde- Poster No. 1678 Rosen, Patrick Smolinski, Freddie H. Fu Investigating the Transverse Cross-section of the Lateral Hinge in Medial Opening Wedge High Tibial Poster No. 1688 Osteotomy Commonly Used Acl Autografts Size Are Not Correlated James Liston, Martin Jaere, Gareth Jones, Anthony Leong, With The Size Of Acl Footprint And Femoral Condyle Justin Cobb Takanori Iriuchishima, Keinosuke Ryu, Shin Aizawa, Freddie H Fu PS2 Knee - Knee Ligament Poster No. 1689 Poster No. 1679 The Most Important Fibers In The Femoral Attachment Neuromuscular Training Following ACLR Affects Of The Anterior Cruciate Ligament For Resisting Tibial Kinematics and Kinetics at 1 year Displacements Ryan Zarzycki, David Logerstedt, Lynn Snyder-Mackler Yasuyuki Kawaguchi, Eiji Kondo, Ryo Takeda, Camilla Halewood, Keiichi Akita, Kazunori Yasuda, Andrew A Amis Poster No. 1680 Quantitative Assessment Of The Pivot-shift Test For Poster No. 1690 Anterior Cruciate Ligament Injuries Using A Gyroscope Graft Shift In The Femoral Tunnel In Anterior Cruciate Atsunori Murase, Masahiro Nozaki, Masaaki Kobayashi, Ligament Reconstruction; An Experimental Study Hideyuki Goto, Tetsuya Takenaga, Yuko Nagaya, Hiroto Masataka Fujii, Yusuke Sasaki, Daisuke Araki, Takayuki Mitsui, Hideki Okamoto, Hirotaka Iguchi, Takanobu Otsuka Furumatsu, Shinichi Miyazawa, Toshifumi Ozaki, Monica Linde-Rosen, Patrick Smolinski, Freddie H Fu Poster No. 1681 Steeper Tibial Posterior Slope is a Risk Factor in ACL Poster No. 1691 Injury - Gait Simulation by a Lower Extremity Model Development of a Novel “Hybrid” Double-bundle ACL H Marouane, A. Shirazi-Adl, M Adouni, J. Hashemi Reconstruction Technique in a Translational Large Animal Model Poster No. 1682 Farrah A Monibi, Patrick Smith, James P Stannard, Keiichi Reconstruction of the Anterior Cruciate Ligament: Kuroki, Chantelle Bozynski, Ferris Pfeiffer, Cristi Cook, Characterization in a New Murine Model James Cook Brian M Grawe, Xiangyu Gu, Camila Carballo, Boyce Collins, Jeffrey Willey, Liang Ying, Ian D Hutchinson, Xiang-Hua Poster No. 1692

Deng, Scott Rodeo ACL Graft Movement Relative to a Bone Tunnel Differs POSTERS with Tunnel Orientation Poster No. 1683 Alexander Kharlamov, Thomas W Jordan, Sam Akhavan, Intra-articular Graft Length In Double Bundle Posterior Mark C Miller Cruciate Ligament Reconstruction Masahiro Nozaki, Masaaki Kobayashi, Hideyuki Goto, Poster No. 1693 Atsunori Murase, Tetsuya Takenaga, Yuko Nagaya, Hiroto Macroscopic Anatomic, Histologic, and Magnetic Mitsui, Hirotaka Iguchi, Takanobu Otsuka Resonance Imaging Correlation of the Lateral Capsule of the Knee Poster No. 1684 Malcolm Dombrowski, Joanna Costello, Bruno Ohashi, Three-Dimensional CT Analysis of Posterolateral Christopher D Murawski, Nicole Friel, Fabio Arilla, Ben Femoral Tunnel in Double Bundle ACL Reconstruction. Rothrauff, Freddie H. Fu, Volker Musahl Comparison of Ourside-in and Transportal drilling Techniques Shunichiro Kambara, Hiroshi Nakayama, Motoi Yamaguchi, Akio Matsumoto, Ken Sasaki, Kaori Kashiwa, Tomoya Iseki, Shinichi Yoshiya 131 Poster No. 1694 PS2 Hip - FAI and Morphology Evaluation of a Multivariate Risk Model for ACL Injury Johanna Kelley, Erin C Argentieri, Daniel Robert Sturnick, Poster No. 1703 Pamela M Vacek, Robert J Johnson, James Slauterbeck, Evaluation of Bone Turnover in Femoroacetabular Timothy W Tourville, Bruce Beynnon Impingement by 18F-Fluoride Positron Emission Tomography Poster No. 1695 Naomi Kobayashi, Yutaka Inaba, Taro Tezuka, Hiroyuki Ike, Respective In-Situ Length Change of Two Functional So Kubota, Masaki Kawamura, Tomoyuki Saito Bundles of the Anterior Cruciate Ligament Under Various Knee State Poster No. 1704 Yoshimasa Fujimaki, Eric D Thorhauer, Christopher D Does Acetabular Morphometry Differ Between Murawski, Yusuke Sasaki, Scott Tashman, Patrick Smolinski, Symptomatic And Asymptomatic Cam-type Freddie H Fu Femoroacetabular Impingement? Kathryn Culliton, Paul E Beaule, Andrew D Speirs Poster No. 1696 Radiographic Landmarks for Identifying the Poster No. 1705 Anterolateral Ligament Effect of Cam Femoroacetabular Lakshmanan Sivasundaram, Nathanael D Heckmann, Impingement on Hip Translation Diego Villacis, Matthew Kleiner, Anthony Yi, Eric White, Laura E Callan, Michael Gilbart, David R Wilson George F Hatch Poster No. 1706 Poster No. 1697 Diagnostic Effectiveness of Ultrasound Examination in Biomechanical And Histological Evaluation Of Normal Patients with Risk Factors for Developmental Dysplasia Rat Knee Ligaments And Patellar Tendon of the Hip Xiangyu Gu, Zoe M Album, Scott Rodeo Jr, Michael Mosca, Thu-Ba Leba, Kelly D. Carmichael, Leonard E. Swischuk Arielle J Hall, Hongsheng Wang, Lilly Ying, Xiang-Hua Deng, Scott Rodeo Poster No. 1707 Vibratory Sense Deficits in Subjects with Symptomatic Poster No. 1698 Femoroacetabular Impingement Effects of Anterolateral Capsular Injury and Extra- Gary J Farkas, Najia Shakoor, Renee Kawecki, Simon Lee, Articular Tenodesis on Knee Kinematics During Kharma Foucher, Alejandro Espinoza-Orias, Shane J Nho Physical Examination Fabio V Arilla, Ata Azar, Benjamin Scott, Carlos Yacuzzi, PS2 Hip - Mechanics - Kinematics Daniel Guenther, Freddie Fu, Richard Debski, Volker Musahl Poster No. 1708 Evaluation of Variability in Head Impaction Forces PS2 Hip - Disease Process Among Multiple Orthopaedic Surgeons Gregg Schmidig, Laura Scholl, Mayur Thakore, Poster No. 1699 Ahmad Faizan Effects of Erythropoietin and GCSF on Traumatic Osteonecrosis of the Femoral Head in Rabbits Poster No. 1709 AliSina Shahi, Timothy Tan, Mohammad Ghoraishian, Joint Angle and Minimum Bone-to-Bone Distance Peter Park, Hamid Reza Seyyed Hosseinzadeh Changes in the Hip Joint during Inclined Walking Niccolo Fiorentino, Michael Kutschke, Penny Atkins, Poster No. 1700 Justine Goebel, Ashley Lynn Kapron, Kenneth B Foreman, Volumetric Assessment of Muscle Andrew E Anderson POSTERS Atrophy After Hip Arthroplasty Christian Klemt, Johann Henckel, Marc Modat, Shiraz Poster No. 1710 Sabah, Reshid Berber, Keshthra Satchithananda, Does Ligamentum Teres Contribute to Hip Stability? Sebastien Ourselin, Alister Hart Suenghwan Jo, Alexander W Hooke, Kai-Nan An, Rafael J Sierra, Robert T Trousdale Poster No. 1701 Nerve Growth Factor AffectsC haracteristics Of Sensory Poster No. 1711 Innervation And Synovia Of The Hip In Rat Effect of Various Surgical Approaches on the Patterns Takanori Omae, Junichi Nakamura, Shigeo Hagiwara, and Magnitudes of Hip Separation Shuichi Miyamoto, Shunji Kishida Michael LaCour, Bradley A Meccia, Adrija Sharma, Richard D Komistek Poster No. 1702 Native Combined Anteversion Influenced Onset of Pain Poster No. 1712 in Patients with Hip Dysplasia Comparison of Different Test Models to Measure Yusuke Kohno, Yasuharu Nakashima, Mio Akiyama, Frictional Torque Generated on the Articulating Masanori Fujii, Yukihide Iwamoto Surfaces of THR Laura Scholl, Lokesh K Raja, Jim Nevelos, Jason Longaray, Lizeth Herrera, Gregg Schmidig, Mayur Thakore

132 Poster No. 1713 Poster No. 1722 Differences in Hip and Knee Mechanics during Three Asymmetrical Hip Kinematics during Gait in Variations of the Single Leg Squat in Healthy Females Unilateral Total Hip Arthroplasty Patients Anne Khuu, Eric Foch, Cara L Lewis Tsung-Yuan Tsai, Jing-Sheng Li, Dimitris Dimitriou, Harry E Rubash, Guoan Li, Young-Min Kwon PS2 Hip and Knee Arthroplasty - Kinematics Poster No. 1723 Poster No. 1714 Does Implant Orientation Influence Functional Pelvic Navigation-based In Vivo Knee Kinematics Stability In Female Patients With Unilateral Total Hip Of The New Gradually Reducing Radii Design Arthroplasty? Total Knee Arthroplasty Donna Moxley Scarborough, Tova L Kosowsky, Tsung-Yuan Hiroshi Takagi, Atsushi Sato, Soshi Asai, Takashi Atsumi Tsai, Young-Min Kwon

Poster No. 1715 Poster No. 1724 Kinematic Analysis Of Stair-climbing In Cruciate- A Surgical Concept to Restore the Natural Flexion retaining And Posterior-stabilized Total Coronal Alignment of the Lower Extremity with Well- Knee Arthroplasties Balanced Flexion Gap in Posterior-stabilized Total Satoshi Hamai, Ken Okazaki, Hideki Mizu-uchi, Hiroyuki Knee Arthroplasties Nakahara, Takeshi Shimoto, Hidehiko Higaki, Yukihide Hitoshi Nochi, Satomi Abe, Takuya Ruike, Yusuke Sasaki, Iwamoto Hiroshi Ito Poster No. 1716 PS2 Hip and Knee Arthroplasty - Infection Mobile-bearing Tka Reduced The Postoperative Anteroposterior Laxity Comparing To Fixed-bearing Poster No. 1725 TKA In The Same Patients The Incidence Of Bacterial Contamination Inside Yukihide Minoda, Shegekazu Mizokawa, Yoichi Ohta, The Leg Bag, During The Hip Surgery With Lateral Mitsuhiko Ikebuchi, Maki Itokazu, Kazumasa Yamamura, Approach In Lateral Decubitus Position Suguru Nakamura, Hiroaki Nakamura Tomokazu Fukui, Shigeo Fukunishi, Konan Tsuchiyama, Yu Poster No. 1717 Three Dimensional Assessment of Medial- Poster No. 1726 lateral Stability after TKA with A Femoral The Usefulness of New Multiplex real-time PCR Single-radius Design in Diagnosing Periprosthetic Joint Infection Hayato Mine, Ryuichi Gejo, Makiko Nogami, Kazuhito Masaki Kawamura, Yutaka Inaba, Naomi Kobayashi, Yushi Sugimori, Hiraku Motomura, Tomoatsu Kimura Miyamae, Hiroyuki Ike, Taro Tezuka, So Kubota, Tomoyuki Saito Poster No. 1718 Tibiofemoral Articular Contact Kinematics Of The Poster No. 1727 Knee After A Posterior Cruciate Substitue Total Knee Revision Total Hip and Knee Arthroplasty Arthroplasty - A Comparison Between Caucasian And Following Documented Deep Infection: Asian Patients The Utility of Frozen Sections Ji Hoon Bae, Ali Hosseini, Kyung Wook Nha, Sang Eun Park, Grayson A Moore, Malone V. Hill, Ronald W. Lindsey, Andrew A Freiberg, Harry E Rubash, Guoan Li Kelly Stephenson

Poster No. 1719 Poster No. 1728 Does Knee Osteoarthritis AffectT he Femoral Demographic Characteristics Of Patients With Infected Component Position During Total Hip Arthroplasty? Knee Arthroplasty By Organism Genus 3D Model Analysis Richard J Holleyman, Paul N Baker, Andre Charlett, Kwang Woo Nam, Dimitris C Dimitriou, Tsung-Yuan Tsai, Kate Gould, David J Deehan Jing-Sheng Li, Kwan-Kyu Park, Harry E Rubash, Guoan Li,

Young-Min Kwon Poster No. 1729 POSTERS The Utility of MRI with Metal Artifact Reduction Poster No. 1720 Sequencing in Diagnosing Periprosthetic Joint Recovery of Gait and Changes of Pelvic Motion After Infection after Total Hip Arthroplasty Total Hip Arthroplasty Kaitlin M Carroll, Erik Schnaser, Hollis Potter, Michael B Masaya Ueno, Riki Tanaka, Shuichi Eto, Masatsugu Cross Tsukamoto, Shunsuke Kawano, Masaru Kitajima, Motoki Sonohata, Masaaki Mawatari PS2 -Hip and Knee Arthroplasty - Computational Modeling Poster No. 1721 Gap Changes of Medial Osteoarthritic Knees Poster No. 1730 before and after a CR TKA: In-vivo Geometric A Preliminary Colloidal Boundary Lubrication Model Condylar Axis Analyses for Wear Prediction in Total Joint Replacements Kwan Kyu Park, Ali Hosseini, Tsung-Yuan Tsai, Young-Min Sean T O’ Brien, Yunhua Luo, Jan-M. Brandt Kwon, Andrew A Freiberg, Harry E Rubash, Guoan Li

133 Poster No. 1731 PS2 Hip and Knee Arthroplasty - Implant Wear A Comparison Of Femoral Bone-cut Angles Determined By Kinematic Alignment-based Poster No. 1740 Planning And Cylindrical Axis-based Planning Manufacturing Inventory Problems: Implant Tomoki Sassa, Yasuo Niki, Kengo Harato, Takeo Nagura, Adjustability Comes at a Cost, Recall of the Yoshiaki Toyama, Yasunori Suda R3 Acetabular System Kevin Ilo, Emma Derby, Harry Krishnan, Harry Hothi, Poster No. 1732 Robert Whittaker, Gordon Blunn, John Skinner, Alister Hart Predicting the 3D Hip Centre of Rotation Using Contralateral Pelvic Anatomy Poster No. 1741 Matthieu Durand-Hill, Johann Henckel, Keshthra What Effect Does the Strength of the Taper Satchithananda, Jia Hua, John Skinner, Alister Hart Connection Have on Taper Damage in Retrieved Total Hip Devices? Poster No. 1733 Genymphas Higgs, Ryan Siskey, Jeremy L Gilbert, Population-Based Evaluation of Patellar Component William Michael Mihalko, Clare M Rimnac, Steven M Kurtz Design on Size, Coverage and Median Ridge Position Charlie C Yang, Raymond H Kim, Patrick G. Davenport, Poster No. 1742 Todd M. Miner, Douglas A Dennis, Derek R Johnson, Profiling 3rd-body Abrasion In A 10-cycle MOM Peter J Laz Simulator Study - Alumina And Hydroxyapatite Ceramic Particles Compared To PMMA And CoCr Poster No. 1734 As Control Debris No Lift-off Motion Occurs with Proper Coronal Thomas Halim, Ian C Clarke, Michelle Burgett, Thomas K Alignment Regardless of Excessive Collateral Donaldson, Jean Yves Lazennec, Christina Savisaar, Ligament Laxity in Total Knee Arthroplasty John G Bowsher Shinichi Kuriyama, Masahiro Ishikawa, Moritoshi Furu, Hiromu Ito, Shuichi Matsuda Poster No. 1743 Influence of Stem Type on Material Loss Poster No. 1735 at the Metal-on-Metal Pinnacle Taper Junction Incidence of Undesired Collateral Ligament Imbalance Harry Hothi, Robert Whittaker, Jay Meswania, Kevin Ilo, and Instability between Extension and Flexion Reshid Berber, Antti Eskelinen, Gordon Blunn, in Neutrally Aligned Total Knee Arthroplasty for John Skinner, Alister Hart Japanese Patients Yasuo Niki, Kengo Harato, Tomoki Sassa, Takeo Nagura, Poster No. 1744 Shu Kobayashi, Yoshiaki Toyama, Yasunori Suda Frictional Torque In Highly Cross-liked Acetabular Liners After In Vivo Service Poster No. 1736 Shannon Rowell, Michael Duffy, Thomas Zumbrunn, Design and Placement of Unicompartmental Tibial Kartik Mangudi Varadarajan, Orhun Muratoglu Components Based on Morphological Analysis Miriam Chaudhary, Hao Yang Chan, Sally Arno, Aaron Poster No. 1745 Lerner, Christopher Bell, Ravinder Regatte, Peter S Walker Development Of A Wear Model For Lubricated Metal-on-Metal Hip Joints Poster No. 1737 Leiming Gao, Rob W Hewson Evaluation Of Femoral Neck Anteversion Based On Clinical Epicondylar Axis Using The Three-dimensional Poster No. 1746 Preoperative Planning Software “Athena” A Proposed Classification System for Taper Surface Ryuji Ichimura, Makoto Kondo, Yasuo Higuma, Takahiro Morphology: Smooth Vs. Micro-grooved POSTERS Noguchi, Kazuhide Tomari Christina M Arnholt, Richard Underwood, Steven M Kurtz

Poster No. 1738 Poster No. 1747 Evaluation of the Position of the Cup Center and the The Effect Of High Bending Moment On Fretting Flexion Range of Motion after Total Hip Arthroplasty Corrosion And Wear At The Modular Head-Stem Naoya Taki, Naoto Mitsugi, Yuichi Mochida, Masato Junction of Metal On Metal Total Hip Replacements Aratake, Hirohiko Ota, Kentaro Shinohara, Tomoyuki Saito Anna Panagiotidou, Konstantinos Tsitskaris, Jay Meswania, John Skinner, Alister Hart, Fares Haddad, Gordon Blunn Poster No. 1739 Three Dimensional Assessments Of Distal Femur Poster No. 1748 Geometry With Resection Level For Total Knee Is Linear Penetration an Accurate Surrogate Measure Arthroplasty With Asian Peoples for Volumetric Wear in TKR Tibial Liners? Tetsuya Tomita, Yasuo Kunugiza, Yu-Shu Lai, Kazuma Futai, Elmira Moslemi Rad, Christopher B Knowlton, Hideki Yoshikawa, Kazuomi Sugamoto Robin Pourzal, Hannah J Lundberg, Markus A Wimmer

Poster No. 1749 Corrosion and Damage Mechanisms in Retrieved Long-Term TKA Femoral Components Christina M Arnholt, Sevi B Kocagoz, Daniel MacDonald, Jeremy L Gilbert, Arthur Malkani, Gregg R Klein, Clare M 134 Rimnac, Steven M Kurtz Poster No. 1750 Poster No. 1760 Relationship Between TKR Polyethylene Liner Metal Transfer on Ceramic and Metal Heads: Volumetric Wear Rate And Periprosthetic Osteolysis a Retrieval Study Robin Pourzal, Johannes Cip, Christopher B Knowlton, Eliza K Fredette, Daniel MacDonald, Richard Underwood, Elmira Moslemi Rad, Markus A Wimmer Steven M Kurtz

Poster No. 1751 Poster No. 1761 Uhmwpe Particle Delivery And Analgesia Induce Effects of CoCrMo Surface Finishing on Walking Track Alterations In A Murine Tibial UHMWPE Wear In A Pin-On-Disk Test Particle-induced Osteolysis Model Elizabeth Hippensteel, Jason Langhorn Jean Langlois, David Bichara, Daniel Copeland, Moussa Hamadouche, Orhun Muratoglu Poster No. 1762 Medial versus Lateral Thinning in Retrieved Poster No. 1752 Knee Bearings: Fixed-Bearings and Mobile Tribocorrosion in Hard-on-Hard Total Hip Bearings Wear Differently Replacement Bearing Couples John H Currier, Xiaotian Wu, Daniel Santana, Andrew R Beadling, Michael G Bryant, Duncan Dowson, Joseph Cook, Douglas Van Citters Anne Neville Poster No. 1763 Poster No. 1753 Characterizing Head-Neck Junction Wear Helps Knee Wear Measurement Using CMM Scanning: Understand the Mechanism of Failure of Metal A Novel Method Shows Promise on Metal Total Hip Replacements Byoungwook Jang, John H Currier, John Collier, Andreas C Panagiotopoulos, Harry Hothi, Robert Douglas Van Citters Whittaker, Jay Meswania, Paul Bills, Radu Racasan, Gordon Blunn, John Skinner, Alister Hart Poster No. 1754 Corrosion of Cemented Femoral Stems may Poster No. 1764 Contribute to Implant Failure Patient-specific Wear Testing For TKR: The Influence Harry Hothi, Andreas Panagiotopoulos, Reshid Berber, Of Gait And Implant Alignment On Wear Robert Whittaker, Shiraz Sabah, Johann Henckel, Scar Size And Location Gordon Blunn, John Skinner, Alister Hart Ryan Freed, Robin Pourzal, Hannah Lundberg, Markus A Wimmer Poster No. 1755 Tibial Backside Wear Predicted By Cross-shear Model; Poster No. 1765 A Retrieval Study Vitamin E Grafted UHMWPE Knee Inserts Exhibit Kathleen Lewicki, Rayna A Levine, John H Currier, SignificantW ear and Delamination Resistance Douglas Van Citters under Activities of Daily Living Diego A Orozco Villasenor, Jerry Parcell, Alicia Rufner Poster No. 1756 Is There A Difference In Wear Performance Between Poster No. 1766 Scratched Cocr And Ceramic Femoral Heads? Modifications toW ear Particle Analysis Procedure to Kimberly Mimnaugh, Diego A Orozco Villasenor, Improve Percent Yield for Third Body Particles Alicia Rufner Anneliese Heiner, Iraklis Papageorgiou, Kruger Karen, Eileen Ingham, Joanne Tipper, Thomas D Brown Poster No. 1757 How Do Positive and Negative Taper Mismatches Poster No. 1767 Affect theI nterface Mechanics of Modular Modular Junctions in Knee Arthroplasty Devices Head-Neck Junctions? Show Notable Corrosion and Fretting Philip C Noble, Jesal Parekh, Newton Chan John H Currier, Scott Mitchell, John Collier, Michael B Mayor, Rayna A Levine, Douglas Van Citters

Poster No. 1758 POSTERS The Role of Femoral Head Size and Offset Poster No. 1768 on Corrosion in the Bore Is Particle-induced Osteolysis Age Related? Bridget E Shaia, John H Currier, John Collier, Jean LANGLOIS, Amine Zaoui, David Bichara, Morad Douglas Van Citters Bensidhoum, Hervé Petite, Orhun Muratoglu, Moussa Hamadouche Poster No. 1759 Increased Torque in Hip Replacement Bearings Poster No. 1769 due to Translational Surgical Mal-Positioning Three THAs Paired With Highly Cross-linked UHMWPE Mazen Al-Hajjar, Philippa Clarkson, Sophie Williams, Liners Revised For Taper Junction Corrosion Louise M Jennings, Jonathan Thompson, Graham H Isaac, Shannon Rowell, Christopher Reyes, William Tomford, Eileen Ingham, John Fisher Young-Min Kwon, Dennis Burke, Henrik Malchau, Orhun Muratoglu

135 Poster No. 1770 Poster No. 1780 A Novel Material “Carbide-Derived-Carbon (CDC)” to Defining High Activity in Arthroplasty Patients Improve Tribological Properties of MoM Hip Implants Nicholas B Robertson, Andrew Battenberg, Michael Eik-lang Lau, Maria Runa, Michael Mcnallan, Kertzner, Thomas P Schmalzried Mathew Mathew Poster No. 1781 Poster No. 1771 Correlation Between a Dedicated Orthopedic Validation Study for a Quantitative Method to Measure Complication Grading System and Early Adverse the Volumetric Material Loss from Taper Surfaces Outcomes in Joint Arthroplasty Sevi B Kocagoz, Richard Underwood, Daniel MacDonald, Dorothy Y Harris, Jillian McAngus, Yong-Fang Kuo, Doruk Baykal, Judd Day, Steven M Kurtz Ronald W. Lindsey

PS2 Hip and Knee Arthroplasty - Clinical Outcomes Poster No. 1782 Research Unicondylar Knee Arthroplasty in the U.S. Patient Population: Prevalence and Epidemiology Poster No. 1772 Kevin L Ong, Edmund Lau, Steven Kurtz, Erik Hansen, Comparison of Patient Function Six Weeks after Jess Lonner Surgery Between Balanced and Unbalanced Total Knee Arthroplasties Poster No. 1783 Cale Jacobs, Christian Christensen Assessing And Quantifying Instability In Revision Total Knee Arthroplasty Poster No. 1773 David F Hamilton, Richard Burnett, James T Patton, Rotational Alignment Of Tibial Prosthesis Using Medial Colin R Howie, Hamish Simpson Border Of Tibial Tubercle In Mobile-bearing TKA Yoshinori Ishii, Junko Sato, Hideo Noguchi Poster No. 1784 Comparative Survival Analysis of Two Porous Metal Poster No. 1774 Acetabular Components in Total Hip Arthroplasty Intra-operative Procedures for Factors Influencing Peter Hsiue, Emil Vutescu, Wayne Paprosky, Sumon Nandi Flexion Angle Before and After PS-TKA Ryuji Nagamine, Makoto Kawasaki, Mitsugu Todo, Poster No. 1785 Weijia Chen To Brace Or Not To Brace: Association Between Pre- And Post- Tka Brace Use And Short-term Outcomes Poster No. 1775 Kevin L Ong, Edmund Lau, Michael A Mont, Michael Retention Of The Posterior Cruciate Ligament Does Manley, Steven Kurtz Not AffectF emoral Rotational Alignment In TKA Using A Gap-balance Technique Poster No. 1786 Yoshinori Ishii, Hideo Noguchi, Junko Sato Peri-prosthetic Bone Mineral Density after Bilateral TKA: Mobile vs. Fixed Bearing prostheses Poster No. 1776 Suguru Nakamura, Yukihide Minoda, Shigekazu Mizokawa, Orthopedic Surgeons Rank Low in Total Medicare Yoichi Ohta, Maki Itokazu, Kazumasa Yamamura, Hiroaki Payments: Evaluation of the Medicare Provider Nakamura Utilization and Payment Database Daniel A Belatti, Andrew James Pugely, Phinit Phisitkul, Poster No. 1787 Annunziato Amendola, John Callaghan Functional Outcomes of Direct Anterior Approach and Mini-Posterior Approach for Total Hip Arthroplasty Poster No. 1777 Kenton Kaufman, Michael Taunton, Melissa Morrow, Rafael POSTERS Total Joint Arthroplasty in Patients with Chronic J Sierra, Robert Trousdale, Mark Pagnano Renal Disease: Is It Worth the Risk? Lucian Warth, Andrew James Pugely, Christopher Martin, Poster No. 1788 Yubo Gao, Nicolas Noiseux, Melissa Willenborg, THA Functional Outcomes Are Independent John Callaghan of Acetabular Component Orientation When a Polyethylene Liner is Employed Poster No. 1778 Jacob Bobman, Jonathan Danoff, Oladapo Babatunde, What Can Be Learned From Minimum 20 Year Katie Peyser, Calvin Zhu, Jeffrey Geller, William Macaulay Follow-Up Studies ofHip Replacement? Christopher Martin, John Callaghan, Lucian Warth, Steve Poster No. 1789 Liu, Devon Goetz, Andrew James Pugely, Nicolas Noiseux, Are There Any Good Patient Reported Outcome Melissa Willenborg, Yubo Gao, Richard Johnston Questionnaires For Patients Undergo Total Hip Arthroplasty? Systematic Reviews On Psychometric Poster No. 1779 Property Evaluations And Methodological Quality Osseous Response Of Four Different Types Of Assessments Cementless Stems In Primary Total Hip Arthroplasty Hsiaomin Huang, Megan Mullins, Heather Stone, Anna Taro Tezuka, Yutaka Inaba, Naomi Kobayashi, Hiroyuki Ike, Ghambaryan, Kevin Troyer, Nilsa Loyo-Berrios, Benjamin So Kubota, Masaki Kawamura, Tomoyuki Saito Eloff, Manuel Bayona, Danica Marinac-Dabic, Faisal Mirza, Joel Gagnier

136 Poster No. 1790 PS2 Hip and Knee Arthroplasty - Polyethelene and The Relationship Between Alignment, Function And Biomaterials Loading In Total Knee Replacement: In-Vivo Analysis Of A Unique Patient Population Poster No. 1800 David E Williams, Andrew Metcalfe, June Madete, Gemma Silver Chromium Nitride Coatings for the Whatling, Paul Biggs, Alexis Roux, Peter J Kempshall, Generation of Particulate Silver Kathleen Lyons, Mark Forster, Catherine A Holt Danielle de Villiers, Agata Nyga, Terry Tetley, Sarah Banfield, Jonathan Housden, Alister Hart, Alison Traynor, Poster No. 1791 Julia C Shelton Differences in Total Hip Replacement Outcomes based on Age Poster No. 1801 Leslie Harrold, David Ayers, Wenjun Li, Courtland Lewis, Hip Simulator Study on the effect of Acetabular Philip C Noble, Regis J O’Keefe, Jeroan Allison, Bearing Design on Frictional Torque Patricia Franklin Jason A Longaray, Reginald Lee, Lizeth Herrera, Amber Schweitzer, Aaron Essner Poster No. 1792 What Are Important Surgical Factors Affecting Poster No. 1802 Wound Healing after Primary Total Knee Arthroplasty? Corrosion Behavior of Medical-Grade Ti-6Al-4V Kengo Harato, Yasuo Niki, Takeo Nagura, Toshiro Otani, Exposed to Tensile Loads Yoshiaki Toyama, Yasunori Suda Pooja Panigrahi, Amir Poursaee, Melinda Harman

Poster No. 1793 Poster No. 1803 Post-Recall Retrieval Analysis of Metal-on- Retrieval Analysis of Short - Term Anti-Oxidant Metal Total Hips Stabilized Highly Crosslinked UHMWPE Used in Patricia Campbell, Sang-Hyun Park, Zhen Lu Knee and Hip Arthroplasty Komal Mehta, Daniel MacDonald, Gregg R Klein, Poster No. 1794 Mark A Hartzband, Harlan M Levine, Michael A Mont, Patient Reported Outcome Questionnaires For Steven M Kurtz Total Knee Arthroplasty: A Systematic Review Of Psychometric Property Evaluations And Poster No. 1804 Methodological Quality Assessments Quantification of Antioxidant Megan Mullins, Hsiaomin Huang, Faisal Mirza, Manuel Concentration in UHMWPE Bayona, Heather Stone, Kevin L Troyer, Anna Ghambaryan, Michelle A Ross, David B Warner, Nilsa I Loyo-Berrios, Benjamin Eloff, Danica Marinac-Dabic, Celia E Macias Gupta, Venkat S Narayan Joel J Gagnier Poster No. 1805 Poster No. 1795 Assesment of Methods for Quantification of Gender Role in Perioperative Outcomes Antioxidant Stabilized UHMWPEs in Total Knee Arthroplasty Michelle A Ross, David B Warner, Celia E Macias Gupta, Sapan Shah, David Mossad, Olivia Wang, Mark H Gonzalez Venkat S Narayan

Poster No. 1796 Poster No. 1806 Use of a Computerized Arthroplasty Registry Variation of Mechanical Properties with Oxidation in to Generate Operative Notes Decreases Highly Crosslinked Remelted UHMWPE Transcription Errors Mitchell Fung, Steven D Reinitz, Douglas W Van Citters Todd M Miner, Raymond H Kim, Charlie C Yang, Douglas A Dennis, David N Conrad, Justin Duke Poster No. 1807 Reduction of In Vivo Oxidation induced by Lipid Poster No. 1797 Absorption by Phospholipid Polymer Grafting on Impact of Intravenous Ketorolac on Orthopedic Bearings

Complications after Total Knee Arthroplasty Masayuki Kyomoto, Toru Moro, Shihori Yamane, Kenichi POSTERS Clifford K. Boese, Leslie Centeno, Ryan Walters, Watanabe, Sakae Tanaka, Kazuhiko Ishihara Brian Cooley, Bridget Scherrer Poster No. 1808 Poster No. 1798 Tibial Insert Retrievals Allow Comparison of Wear and Assymentric Tibial Component Reduced Oxidation in Conventional and Highly Cross-linked The Risk Of Malrotation In TKA UHMWPE Yukihide Minoda, Shegekazu Mizokawa, Yoichi Ohta, Barbara H Currier, John H Currier, Xiaotian Wu, Rayna A Maki Itokazu, Kazumasa Yamamura, Suguru Nakamura, Levine, Douglas Van Citters Hiroaki Nakamura Poster No. 1809 Poster No. 1799 Dynamic Mechanical Analysis As A Tool For Differences in Total Knee Replacement Understanding Entanglements And Outcomes based on Age Cross-links In UHMWPE Leslie Harrold, David Ayers, Wenjun Li, Vincent Pellegrini, Steven D Reinitz, Anna M Gottardi, Kathleen A Lewicki, John Grady-Benson, Jeroan Allison, Patricia Franklin Douglas W Van Citters 137 Poster No. 1810 Poster No. 1819 A Comparison of Wear and Wear Particles Generated Effects Of Repetitive Training Practices Using A by Injection Molded PEEK-based Materials with Computer-assisted Guidance System On Cognitive Cross Linked Polyethylene Sliding Against Metal And Technical Skills and Ceramic Counterface in a Simple Configuration Laurent Angibaud, Ralph Liebelt, Bo Gao, Xeve Silver Wear Simulation Salah Hammouche, Joanne L. Tipper, John Fisher, Poster No. 1820 Sophie Williams Evaluation Of Knee Deformity On Alignment Discrepancies During Total Knee Arthroplasty Poster No. 1811 Using A Computer-assisted Guidance System PEEK And CFR-PEEK As An Alternative To Laurent Angibaud, Ralph Liebelt, Bo Gao, Xeve Silver UHMWPE In Total Knee Replacement Claire L Brockett, Silvia Carbone, John Fisher, Poster No. 1821 Louise Jennings Patient Factors Influencing Mediolateral Compartment Force Imbalances During Total Knee Arthroplasty Poster No. 1812 Cale Jacobs, Christian Christensen Effects Of Absorbed Lipids On Fatigue Crack Growth Rates Of Ultra-high Molecular Weight Polyethylene. Poster No. 1822 Hideyuki Sakoda, Shingo Niimi Accuracy Of Component Orientation And Leg Length Adjustments Using A Revised Version Image-free Poster No. 1813 Navigation In Total Hip Arthroplasty Molecular Weight Characterization To Assess Aging In Yu Takeda, Shigeo Fukunishi, Shoji Nishio, Yuki Fujihara, Ultra High Molecular Weight Polyethylene Tomokazu Fukui, Shinichi Yoshiya Norma Turner, Stephen H Spiegelberg, Kim-Phuong Le, Jacob Blitz, Lin Song PS2 Hip and Knee Arthroplasty - Osteolysis and Adverse Soft Tissue Reaction PS2 Hip and Knee Arthroplasty - Finite Element Analysis Poster No. 1823 Poster No. 1814 Murine Model Of Particle-induced Osteolysis Using Do Modeling Choices Have a Large Influence on A Titanium Tibial Implant To Test The Influence Of the Prediction of “Fretting Wear” at the Cone-Head Aging On Bone Turnover Interface? Jean Langlois, David Bichara, Bertrand David, Herve Petite, Thom Bitter, Dennis Janssen, Berend W. Schreurs, Keith Wannomae, Moussa Hamadouche, Orhun Muratoglu Gerjon Hannink, Timothy E Marriott, Imran Khan, Nico Verdonschot Poster No. 1824 Teriparatide vs. Alendronate For The Preservation Poster No. 1815 Of BMD Around Femoral Implant And In The Lumbar Prediction of the Long-term Course of the Cementless Spine After Total Hip Arthroplasty Femoral Stem Based on Finite Element Analysis and Makoto Uchiyama, Yutaka Inaba, Naomi Kobayashi, Mid-term Radiological Evaluation Hiroyuki Ike, Taro Tezuka, Satoshi Kubota, Masaki Kanehiro Matsuyama, Yasuhiro Ishidou, Yong-Ming Guo, Kawamura, Tomoyuki Saito Hironori Kakoi, Naohiro Shinohara, Yuhei Yahiro, Ichiro Kawamura, Takao Setoguchi, Shingo Maeda, Setsuro Poster No. 1825 Komiya Immunophenotypic Analysis of Peripheral Blood Lymphocytes in Patients with Hip Implant-Related Poster No. 1816 Metal Hypersensitivity POSTERS Bone Grafting With An Acetabular Reinforcement Eric A Lehoux, Ian Hurda, Stephen J Baskey, Paul E Beaulé, Ring: Effects Of The Graft Location According To Isabelle Catelas 3-dimensional Finite Element Analysis Koji Totoribe, Etsuo Chosa, Go Yamako, Xin Zhao, Shinji Poster No. 1826 Watanabe, Hiroaki Hamada, Gang Deng Do Metal Ion Levels Normalize Following Revision Surgery for ‘Pseudotumours’ in Patients with Corrosion Poster No. 1817 of Dual Taper Modular THA? Investigation of Novel Unicompartmental Knee Young-Min Kwon, Tsung-Yuan Tsai, William Leone, Guoan Component Designs for Medial Osteoarthritis Li, Harry E Rubash, Andrew A Freiberg Miriam E. Chaudhary, Joseph Bosco, Chih-Shing Wei, Peter S Walker Poster No. 1827 Histopathology of Pseudotumours in Corrosion of PS2 Hip and Knee Arthroplasty - Surgical Navigation Dual Taper Modular Femoral Stem: Hypersensitivity or Outcomes and Robotics Dose-Dependent Reaction? Young-Min Kwon, Kenneth Urish, Tsung-Yuan Tsai, Guoan Poster No. 1818 Li, Andrew A Freiberg, Harry E Rubash Bone Preservation in a Customized, Individually Made Total Knee Replacement John E Slamin, William B Kurtz, Scott Doody

138 Poster No. 1828 Poster No. 1838 The Effect of Wear Particles from Hard-on-Hard Total How Does Ambient Temperature and Time to Hip Replacements on the Cell Plasma Membrane Implantation AffectI ntrusion Depth? A Comparative Ruth Craven, Lars Jeuken, Sophie Williams, Joanne Tipper Bone Cement Study Andrew Pytiak, Nathaniel Jove, Laryssa A Korduba- Poster No. 1829 Rodriguez, Shulin He, Frank Sagato, Marc Esformes, Immunohistochemical Localization And Cellular David C Markel Reaction Of Tlr2 And Nlrp3 Cascades In Aseptic Loosening Of Totally Replaced Hip Joints Poster No. 1839 Yasushi Naganuma, Tomoyuki Hirayama, HIroharu Oki, Mediolateral Subsidence Assessment of a Novel Suran Yang, Yasunobu Tamaki, Yuya Takakubo, Kan Sasaki, Unicondylar Porous Baseplate Keel Design Michiaki Takagi Gokce Yildirim, Robert Davignon, Laura Scholl, Gregg Schmidig PS2 Hip and Knee Arthroplasty - Implant Fixation Poster No. 1840 Poster No. 1830 The Position of Components using the Modified Practical Method to Dynamically Measure 3-D Gap-Balancing Technique after Posterior Stabilized Implant Motion In Cadaveric Specimens Type Total Knee Arthroplasty Nicholas J Stroud, Cameron Staunch Makoto Kawasaki, Ryuji Nagamine, Kei Osano, Koichiro Tanaka, Mitsugu Todo, Akinori Sakai Poster No. 1831 Is The Anterior Approach Associated With A Higher PS2 Shoulder and Elbow - Computational Modeling Risk Of Femoral Component Migration? Paul E Beaule, Alex Page, Ashley Drodge, Peter Breithaupt Poster No. 1841 A Finite Element Analysis of Mechanical Trade-Offs Poster No. 1832 Encountered In Changing Centers of Rotation In Acid Etch To Increase Debonding Strength At PMMA Reverse Shoulder Arthroplasty Cement And CoCrMo Interface Vijay N Permeswaran, Donald D Anderson, Jessica E Goetz, Weidong Tong, Steve Leisinger Carolyn M Hettrich

Poster No. 1833 Poster No. 1842 Rim Defect Repair in Healthy and Osteoporotic Glenohumeral Anatomy Study: A Comparison Patients Using Cement Augmentation Of Male And Female Shoulders With Similar Farid Amirouche, Giovanni F Solitro, Mark Gonzalez, Average Age And Bmi Wayne M Goldstein Amanda Jacobson, Matt Hamilton, Alex Greene, Pierre Henri Flurin, Thomas Wright, Joseph Zuckerman, Poster No. 1834 Christopher Patterson Roche Broaching of the Proximal Femur in Preparation for a Femoral Hip Prosthesis: Density of Cancellous Bone in Poster No. 1843 Region Immediately Around Broach Canal Shoulder Instability Computer Model Replicates Dan Huff, Alex Maile, Niklas B Damm, Nicholas E Bishop, Patient Range of Motion When Simulating Michael Morlock Capsular Plication Charlie Yongpravat, Eugene W Brabston, Daniel Briggi, Poster No. 1835 Charles A Popkin, Charles M Jobin, William N Levine, Migration Of Trident Tritanium Ingrowth Actebular Thomas R Gardner, Christopher S Ahmad Components Assessed With RSA Rene ten Broeke, Jan Geurts, Elisabeth Jutten, Boudewijn Poster No. 1844 Brans, Lennard Koster, Marloes Peters, Bart Kaptein, WITHDRAWN Chris Arts Poster No. 1845

Poster No. 1836 WITHDRAWN POSTERS Can the Pre-operative Femoral Neck Geometry Be Used to Predict Post-operative Femoral Stem Poster No. 1846 Anteversion in THA Patients? WITHDRAWN Kwan Kyu Park, Tsung-Yuan Tsai, Dimitris Dimitriou, Harry E Rubash, Guoan Li, Young-Min Kwon Poster No. 1847 T he Effect of Cement Morphology on Surrounding Poster No. 1837 Stress of Implanted Cadaveric Glenoids: Initial Stability of Cementless Femoral Stems: An In Micro-Finite Element Analysis Vitro Technique to Measure Micromotion and Gap Hwa Bok Wee, April Armstrong, Wesley Flint, Around the Loaded Stem Gregory S Lewis Valérie Malfroy Camine, Hannes A Rüdiger, Dominique P Pioletti, Alexandre Terrier Poster No. 1848 Influence Of Length On The Biomechanical Performance Of Humeral Stems In Shoulder Arthroplasty Jeff Bischoff, Charles L Penninger 139 PS2 Shoulder and Elbow - Arthroplasty Poster No. 1858 Association Between Shoulder Subluxation Poster No. 1849 And Rotator Cuff MusclesD egeneration Biomechanical Effectiveness Of Glenohumeral In Osteoarthritic Shoulders Tendon Transfers Performed With Reverse Shoulder Alexandre Terrier, Julien Ston, Alain Farron Arthroplasty To Restore External Rotation Jean-David Werthel, Alexander Hooke, Taku Hatta, Eric PS2 Shoulder and Elbow - Kinematics and Mechanics W agner, Kai-Nan An, John Sperling, Bassem Elhassan Poster No. 1859 Poster No. 1850 What Shoulder Motions Are Safe After Rotator Changes in Glenohumeral Muscle Moment Arms CuffR epair? - A Biomechanical Study For Safe Following Reverse Shoulder Arthroplasty: Rehabilitation Protocols a Biomechanical Study Satoshi Oki, Noboru Matsumura, Yoshimori Kiriyama, Jean-David Werthel, Alexander Hooke, Taku Hatta, Yoshiaki Toyama, Takeo Nagura Eric Wagner, Kai-Nan An, Bassem Elhassan, John Sperling Poster No. 1860 Poster No. 1851 Joint Motion Remains Altered Following Factors Related to Improved Quality of Life in Remobilization in an Animal Model of Operative and Non-operative Patients Post-Traumatic Elbow Contracture Joel J Gagnier, Bruce S Miller, James E Carpenter, Ryan M Castile, Leesa Galatz, Spencer Park Lake Asheesh Bedi, Christopher B Robbins Poster No. 1861 Poster No. 1852 Biomechanical Comparison of Traditional Anchors The Effect of Material Selection and Implant to All-Suture Anchors in a Double-Row Rotator Positioning on Cartilage Stresses Following Partial CuffR epair Cadaver Model Joint Resurfacing: A Finite Element Study Todd Baldini, Andrew Goschka, Jason Hafer, Monica Jacob M Reeves, Najmeh Razfar, Dan Langohr, George S Hawkins, Kirk Reynolds, Nicholas Aberle, Eric McCarty Athwal, Graham J King, James A Johnson Poster No. 1862 Poster No. 1853 Strain of the Tendon After Tranosseous Reliability Of Assessment Of Component Position With Equivalent Repair: A Cadaveric Study Three-dimensional Computed Tomography Imaging Hideaki Nagamoto, Nobuyuki Yamamoto, Yuki Shiota, Following Total Shoulder Arthroplasty; Comparison Jun Kawakami, Takayuki Muraki, Eiji Itoi Of Analysis Techniques Eric T Ricchetti, Bong Jae Jun, Richard A Cain, Eric J Poster No. 1863 Rodriguez, David Kusin, Naveen Subhas, Thomas E Impact of Humeral Offset on Muscle Length Patterson, Joseph P Iannotti with Reverse Shoulder Arthroplasty Christopher Patterson Roche, Phong Diep, Matt Hamilton, Poster No. 1854 Thomas Wright, Pierre Henri Flurin, Joseph Zuckerman, Sequential Three-dimensional Computed Howard Routman Tomography Analysis Of Implant Position Following Total Shoulder Arthroplasty Poster No. 1864 Eric T Ricchetti, Richard A Cain, Bong Jae Jun, Ari Tracking Shoulder Implant Motion Using Biplanar Youderian, Eric J Rodriguez, David Kusin, Naveen Subhas, Videoradiography: An Accuracy Study Thomas E Patterson, Joseph P Iannotti Tarpit Patel, Alexia Stylianou, Joel Schwartz, Andrew Green, Joseph Trey Crisco POSTERS Poster No. 1855 Factors Associated with Rotator CuffT ears in Total Poster No. 1865 Shoulder Arthroplasty (TSA) Explored Minimal Effect of Compressive Loading on the Matthew T Binkley, Scott Nodzo, Philip Stegemann, Glenohumeral Joint Stability Ratio Thomas Duquin Piyush Walia, Ronak Patel, Lionel Gottschalk, Matthew Kuklis, Morgan Jones, Stephen Fening, Anthony Miniaci Poster No. 1856 Accuracy Of Pre-operative Glenoid Correction In Poster No. 1866 Reverse Shoulder Arthroplasty: Comparison Of Biceps Detachment Alters Rotator CuffT endon 3d-interactive And Traditional Methods Properties and Joint Function in a Supraspinatus Julien Berhouet, Lawrence Gulotta, Xiang Chen, Daniel Tendon Tear Rat Model Choi, Andreas Kontaxis Jennica J Tucker, Stephen J Thomas, Katherine E Reuther, Chancellor F Gray, Chang S Lee, David L Glaser, Poster No. 1857 Louis J Soslowsky The Effect of Bone Density on Migration of Stemless and Stemmed Humeral Components - Poster No. 1867 A Cadaveric Study Contact Analysis Of The Glenohumeral Joint David M Warlop, Shouchen Dun, Steve Swope, During Simulated Throwing Motion Amit Vasanji Hiroaki Inui, Hiroshi Tanaka, Katsuya Nobuhara

140 Poster No. 1868 Poster No. 1878 Effects of Margin Convergence on Gleno-Humeral Mast Cell Tryptase ModifiesT he Contraction Of Human Joint Contact Area and Contact Pressures Joint Capsule Cells In Vitro Anand Murthi, Vikram Sathyendra, Daniel Acevedo, Kevin A Hildebrand, Lindsey M Logan, Mei Zhang, David A Joseph Abboud Hart, Paul T Salo, A. Dean Befus

Poster No. 1869 Poster No. 1879 Alteration Of Stress Distribution Patterns A Prospective, Quantitative MRI-Based Assessment In The Elbow Medial Collateral Ligament Injury on the Progression of Fatty Infiltration after Tadanao Funakoshi, Kozo Furushima, Naomi Oizumi, Rotator Cuff Repair Yuichiro Abe, Norimasa Iwasaki Drew Lansdown, Sonia Lee, Craig Sam, Roland Krug, Brian T Feeley, C Benjamin Ma Poster No. 1870 Kinematic and Mechanical Analysis of Reverse PS2 Hand and Wrist - Mechanics Shoulder Arthroplasty Glenn Sanders, Mark S Caruso, George Zanaros Poster No. 1880 Side-to-side Versus Pulvertaft Extensor Tendon Repair Poster No. 1871 - Biomechanical Study Measuring Three-Dimensional Thorax Motion Michael Rivlin, Ali Hosseini, Amir Reza Kachooei, Kyle Using Biplane X-Ray Imaging: Technique and Eberlin, Nikola Zivaljevic, Guoan Li, Chaitanya S Mudgal Accuracy Assessment Tim Baumer, Joshua William Giles, Anne Drake, Poster No. 1881 Megan VanLuven, Michael Bey Looped versus Single Stranded Flexor Tendon Repairs: A Cadaveric Mechanical Study PS2 Shoulder and Elbow - Disease Process Ryan P Calfee, Sean Boone, Jeffrey G Stepan, Daniel A Osei, Stavros Thomopoulos, Martin I Boyer Poster No. 1872 Tryptase as a Biomarker of Post-Traumatic Joint Poster No. 1882 Contracture in a Rabbit Model Reducing Radiation Exposure in CT Image-Based Michaela Kopka, Mei Zhang, Michaela J Monument, Kinematic Analysis: Influence on Segmentation and Marvin J Fritzler, David A Hart, A. Dean Befus, Paul T Salo, Automated Kinematic Analysis Kevin A Hildebrand Tarpit Patel, Eni Halilaj, Michael Rainbow, Scott McAllister, Joseph J Crisco, Douglas C Moore Poster No. 1873 The Ability Of Ultrasound To Determine Rotator Poster No. 1883 Cuff Tear Reparability Stepwise Releases of the Flexor Retinaculum Affect Andrew KH Tse, Patrick H Lam, Lisa Hackett, Carpal Tunnel Structural Properties George AC Murrell Kaihua Xiu, Xin Guo, Peter J. Evans, William H Seitz Jr., Zong-Ming Li Poster No. 1874 Can Rotator Cuff Repair Prevent The Progression Poster No. 1884 Of The Osteoarthritis? Characterization of the Hyperelastic Material Tsuyoshi Sasaki, Atsushi Yamamoto, Hitoshi Shitara, Properties of Subsynovial Connective Tissue Tsuyoshi Ichinose, Daisuke Shimoyama, Tsutomu Yusuke Matsuura, Andrew Thoreson, Chunfeng Zhao, Peter Kobayashi, Toshihisa Osawa, Kenji Takagishi C. Amadio, Kai-Nan An

Poster No. 1875 Poster No. 1885 Bone Morphogenetic Proteins Signaling in Rotator Biomechanical Evaluation of Isolated Cuff MusclesF ollowing Massive Tendon Tears Scapholunate Ligament Disruption on Xuhui Liu, Bharat Ravishankar, Dominique Laron, Sunil Dynamic Scapholunate Instability

Kumar Joshi, Tammy Luan, Hubert Kim, Brian T Feeley Matthew E. Hiro, Muturi Muriuki, Corey J. Schiffman, POSTERS Julia Graham, Robert M Havey, Leonard I. Voronov, Poster No. 1876 Avinash G. Patwardhan, Randipsingh Bindra Side-specific Differences In The Supraspinatus Muscle And Tendon Morphological Properties In Collegiate PS2 Hand and Wrist - Reconstruction Baseball Players With And Without Shoulder Injuries Tomonobu Ishigaki, Masanori Yamanaka, Motoki Poster No. 1886 Hirokawa, Yuya Ezawa, Mina Samukawa, Hiroshi Saito, Proximal Tendon-Prosthesis Junction for Active Makoto Sugawara Tendon Implants of the Hand: A Biomechanical Comparison of Two Techniques Poster No. 1877 Matthew J Thompson, John R Owen, Jennifer S Wayne, Musclular Fatty Infiltration Is Mediated By Mmp-13 Charles M McDowell In A Mouse Model Of Rotator CuffT ears Bharat Ravishankar, Tammy Luan, Dominique Laron, Hubert Kim, Brian T Feeley, Xuhui Liu

141 Poster No. 1887 Poster No. 1896 Biomechanical Analysis of Internal Fixation Methods Tarsal Navicular Bone Collapse in Diabetics for Distal Interphalangeal Joint Arthrodesis Douglas D Robertson, Jr, Elie Harmouche, Geza Kogler, Stephanie Rigot, Rafael Diaz-Garcia, Richard E Debski, John Minzhi Xing, Michael Terk Fowler Poster No. 1897 Poster No. 1888 WITHDRAWN Force in the Scapholunate Interosseous Ligament during Physiological Wrist Loading PS2 Foot and Ankle - Mechanics Frederick W Werner, Craig Dimitris, Donald A Joyce, Brian J Harley Poster No. 1899 Reconstruction of the Superior Aspect of the Poster No. 1889 Midfoot Provides Greater Correction than an Secondary And Tertiary Axial Stabilization Of The Anatomic Reconstruction of the Spring Ligament Forearm, A Biomechanical Study Of The Interosseous in a Simulated Flatfoot Deformity Membrane And Triangular Fibrocartilage Complex Josh R Baxter, Jeremy M LaMothe, Raymond J Walls, Daniel R Bachman, Kai-Nan An, Shawn W O’Driscoll Marcelo P Prado, Susannah Gilbert, Jonathan T Deland

Poster No. 1890 Poster No. 1900 Fixation for Metacarpal Neck Fracture: Statistical Assessment Of Load Variations A Biomechanical Study Across Osteotomies In The Foot Pramote Malasitt, John R Owen, Marc A Tremblay, Jeffrey Bischoff, Mehul A Dharia, Jim Woodburn, Scott Jennifer S Wayne, Jonathan E Isaacs Telfer, Amir Al-Munajjed

PS2 Hand and Wrist - Soft Tissue and Nerve Poster No. 1901 Changes in Energy Recovery Following Poster No. 1891 Total Ankle Replacement Electrophysiological Changes of Median Nerve Robin M Queen, Tawnee Sparling, Induced by An Intraoperative Phalen’s Test on Carpal Abigail L Carpenter, Daniel Schmitt Tunnel Syndrome Shigeru Kobayashi, Takafumi Yayama, Kousuke Awara, PS2 Foot and Ankle - Reconstruction and Arthroplasty Adam Meir, Katsuhiko Hayakawa Poster No. 1902 ORS Best Foot and Ankle Poster Poster No. 1892 P redicting Tibial Stress Fields Around Cell-Seeded Contraction Gel Model to Assess TGF-β Total Ankle Replacements and Fibroblast Biomechanics in an Established Rabbit Matthew A Hamilton, Phong Diep, James Nunley, Model of Carpal Tunnel Syndrome James DeOrio, Mark Easley, Victor Valderrabano Tai-Hua Yang, Andrew Thoreson, Anne Gingery, Dirk Larson, Sandra Passe, Kai-Nan An, Chunfeng Zhao, Poster No. 1903 Peter C. Amadio Effect of a Supramalleolar Osteotomy in a Novel Asymmetric Ankle Arthritis Model Poster No. 1893 Jack Anavian, Todd A Fellars, Heather E. Gotha, Light Activated Sealing of Nerve Graft Coaptation Sites Sarath C. Koruprolu, Ryan R. Rich, David Paller, Improves Outcome Following Large Gap Nerve Injury Christopher W DiGiovanni Neil G Fairbairn, Joanna H Ng-Glazier, Amanda M Meppelink, Mark A Randolph, Jonathan M Winograd, Ian L Poster No. 1904 POSTERS Valerio, Mark E Fleming, Robert W Redmond Effect of a Calcaneal Osteotomy in a Novel Asymmetric Ankle Arthritis Model PS2 Foot and Ankle - Adult Jack Anavian, Todd A Fellars, Heather E. Gotha, Sarath C. Koruprolu, Ryan R. Rich, David J. Paller, Poster No. 1894 Christopher W DiGiovanni E xaminations In Relation To Intra-articular Pressure Force Of Talocrural Joint By The Use Of Miniature Poster No. 1905 Pressure Sensor: Comparison Of Three Types Of Screws The Impact of Nitinol Staples on the Compressive On Arthroscopic Ankle Arthrodesis Forces, Contact Area and Mechanical Properties Satoshi Kamijo, Tsukasa Kumai, Shogo Tanaka, Tuyoshi in Comparison to a Claw Plate for the Mano, Yasuhito Tanaka Lapidus Arthrodesis Amiethab A Aiyer, Nicholas A Russell, Matthew H Poster No. 1895 Pelletier, Mark S Myerson, William Robert Walsh Posterior Tibial Dysfunction: Imaging Diagnosis When No MRI Detectable Tendon Pathology Is Present Elie Harmouche, Douglas D Robertson, Jr., Aparna Kakarala, Seth Means, Minzhi Ming, Michael Terk

142 PS2 Infection PS2 Trauma - Clinical Outcomes Methodologies

Poster No. 1906 Poster No. 1915 Next Generation type Silver-containing T he Amplitude of Pulse-Synchronous Intramuscular Hydroxyapatite Coating Pressure Oscillations ascertains the Diagnosis of Iwao Noda, Hiroshi Miyamoto, Masaya Ueno, Shuichi Chronic Compartment Syndrome of the Leg Eto, Masatsugu Tsukamoto, Shunsuke Kawano, Motoki Andreas Nilsson, Qiuxia Zhang, Jorma Styf Sonohata, Masaaki Mawatari Poster No. 1916 Poster No. 1907 Correlation Of NIRS And Histological Muscle Damage IDR-1018: An Immunodulatory Host Defense Peptide In A Prolonged Trauma/infusion Model Of Extremity that Decreases Bacterial Burden and Preserves Compartment Syndrome (ECS) - Assessing NIRS Ability Osseointegration in a Murine Model of Orthopaedic To Detect The Clinical Consequence Of Delayed ECS Implant Infection Steven Budsberg, Michael Shuler, Mellisa Roskosky, Hyonmin Choe, Arvind S Narayanan, David J Corn, Bryan Elizabeth Uhl, Megan Hansen, Brett Freedman S Hausman, Sona Haku, Hani A Essber, Steve H Marshall, Zhenghong Lee, Robert A Bonomo, Edward M Greenfield Poster No. 1917 Biomechanical Evaluation of the Risk of Secondary Poster No. 1908 Fracture around Short vs. Long Femoral Bacterial Suture Adherence and BiofilmF ormation Intramedullary Nails in an In-vivo Contaminated Wound Model William E Daner, John R Owen, Jennifer S Wayne, Michael R Morris, Christopher Bergum, Nancy Jackson, Ryan B Graves, Mark C Willis David Markel Poster No. 1918 Poster No. 1909 Pressure Characteristics of Pelvic Circumferential Comparison of Gown Contamination in Simulated Compression Devices: A Cadaveric Study Total Joint Surgery Brandon T Bucker, John R Owen, Marc A Tremblay, Jamie Fraser, Simon Young, Kimberly Valentine, Nicholas Jennifer S Wayne, Mark C Willis Probst, Mark Spangehl PS2 Trauma - Pathophysiology Poster No. 1910 Impact of Silver Deposition on Staphylococcus aureus Poster No. 1919 Colonization in a Rat Fracture Osteomyelitis Model D elayed Treatment of Critically-sized Femoral Defects Duane A. Robinson, Anne Nicholson, Zach Quanback, in a Rat Model of Chronic Non-union Joan E Bechtold, Lewis G Zirkle, Cathy S Carlson, Dean Albert Cheng, Laxminarayanan Krishnan, Robert E Tsukayama, Andrew Schmidt Guldberg

Poster No. 1911 Poster No. 1920 Antimicrobial Surface By Thin Coating With Ag-silicate The Effects of Ketorolac Tromethamine on Tendons - Platelet Nanohybrids And Waterborne Polyurethane An In Vitro and In Vivo Study on Metal plate Ting Yuan, Jianying Zhang, Guangyi Zhao, Binghua Zhou, Chih-Hao Chang, Yi-Hsiu Huang, Mark Hung-Chih Chen James Wang

Poster No. 1912 Poster No. 1921 Development of a Hematogenous Implant-Related Is It Only Athletes That Tear Their Hamstrings? Osteomyelitis Model A Systematic Review Stefanie M Shiels, Katherine M Bedigrew, Joseph C Wenke David F Hamilton, Barbara Kuske, Sam Pattle, Hamish Simpson Poster No. 1913 The Effect of Postmortem Interval on Human Cadaveric Poster No. 1922

Tissue Seropositivity: A retrospective donor chart Sex-Related Differences in Sports Performance POSTERS review and Injury Amir H. Qureshi, Mark D Barton, Anita Vijapura, H. Thomas Marcia Newby-Goodman, Zbigniew Gugala Temple PS2 Cancer, Tumors Poster No. 1914 False Positive Rate of Serological Screening Poster No. 1923 of Cadaveric Tissue Donors for Human T-cell H ypoxia-induced Transmembrane Carbonic Anhydrase Lymphotrophic Virus 9 Enzyme Inhibitor Suppresses Cell Proliferation, Anita Vijapura, Amir H. Qureshi, Mark D Barton, H. Thomas Migration And Invasion Of Osteosarcoma Temple Kazuma Okuno, Takao Matsubara, Akihiko Matsumine, Kunihiro Asanuma, Tomoki Nakamura, Takahiro Iino, Akihiro Sudo

143 Poster No. 1924 Poster No. 1933 Isocitrate Dehydrogenase 2 Mutation Bone Morphogenetic Protein (BMP) Signaling Induces In Giant Cell Tumor Of Bone the Imprinted Paternally Expressed Gene 10 (PEG10) Masato Sugawara, Xing Liu, Hiroharu Oki, Takashi Tsuchiya, to Regulate Expression of Matrix Metalloproteinase Mika Kaneko Kato, Yukinari Kato, Michiaki Takagi (MMP)-1 and -13 in Chondrosarcoma Cells Naohiro Shinohara, Shingo Maeda, Kanehiro Matsuyama, Poster No. 1925 Yuhei Yahiro, Katsuyuki Imamura, Ichiro Kawamura, Takao The Tyrosine Kinase Inhibitor, R428, Reduces Setoguchi, Satoshi Nagano, Masahiro Yokouchi, Yasuhiro Progression of In Vitro Models of Osteosarcoma Ishidou, Setsuro Komiya Micrometastasis William Z Morris, Christopher T. Manuszak, Ashley N Poster No. 1934 Rettew, Hani A Essber, Christopher Collier, Patrick J. Getty, Microarray and RNA Sequencing Analysis of Pericyte- Edward M Greenfield derived Sarcomas in a Novel Sarcoma Mouse Model Shingo Sato, Qingxia Wei, Makoto Hirata, Yuning Tang, Shu Poster No. 1926 Takeda, Jay Wunder, Benjamin Alman Microrna Mir-326 Promotes Tumor Growth Of Human Synovial Sarcoma Poster No. 1935 Yusuke Minami, Masumi Tsuda, Shinji Kohsaka, Akio Differentiate Human Ovarian Cancer Cell Line with MInami, Shinya Tanaka, Norimasa Iwasaki Different Metastasis Characteristics by Cell Mechanical Properties Poster No. 1927 Chih-Chan Lin, Tzu-Hsiang Lin, Tsung-Hsien Wu, Hsueh- Isocitrate Dehydrogenase 2 Mutation Is Frequently Chun Wang, Meng-Chian Wu, Ho-kai Huang, Yu-Chen Liu, Observed In Osteosarcoma Horng-Chaung Hsu, Ming-Long Yeh Masato Sugawara, Xing Liu, Yasushi Naganuma, Takashi Tsuchiya, Mika Kaneko Kato, Yukinari Kato, Michiaki Takagi Poster No. 1936 A Novel Intraoperative Laser Ablation System for Poster No. 1928 Treatment of Residual Sarcoma Cadherin-11 Has Interactions With Osteoblasts And Alexander L Lazarides, Melodi Whitley, David Strasfeld, Enhances Bone Metastases In Ewing’s Sarcoma Family Diana Cardona, David Kirsch, Brian Brigman, Jorge Ferrer, Of Tumors Suzanne Bartholf DeWitt, William Eward Mihoko Hatano, Yoshihiro Matsumoto, Jun-ich Fukushi, Tomoya Matsunobu, Kunio Iura, Yoshinao Oda, Akira Poster No. 1937 Nabeshima, Nobuhiko Yokoyama, Suguru Fukushima, microRNA-based Therapy For Osteosarcoma Yukihide Iwamoto Hani A. Essber, Eldra W. Daniels, Christopher T. Manuszak, Michael P. Perisa, Xin Chen, Ashley N. Rettew, Patrick J. Poster No. 1929 Getty, Edward M. Greenfield The Overexpression Of Bone Morphogenetic Protein And Activin Membrane-bound Inhibitor In Human Poster No. 1938 Osteosarcoma Cells The Correlation of Malignant Potential with NELL-1 Jung Ryul Kim, Kyu Yun Jang Expression in Benign and Malignant Bone Tumors Gregory Y LaChaud, Jia Shen, Kevork Khadarian, Greg Poster No. 1930 Asatrian, Xinli Zhang, Sarah Dry, Kang Ting, Chia Soo, Proteomic Approaches For DefiningT he Protein Aaron W James ProfilesO f EWS/Fli1 In Ewing’s Sarcomas Yoshiyuki Suehara, Shinji Kohsaka, Kenta Mukaihara, Poster No. 1939

POSTERS Keisuke Akaike, Midori Ishii, Daisuke Kubota, Saiko Kazuno, The Influence of Physical and Physiological Cues Reiko Mineki, Tsutomu Fujimura, Kazuo Kaneko, on Atomic Force Microscopy-Based Cell Stiffness Marc Ladanyi, Tsuyoshi Saito Assessment Yu-Ren Chen, Yu Wei chiou, Ming Lung Yeh Poster No. 1931 Effect of Recombinant Human Bone Morphogenetic Poster No. 1940 Protein-2 on Lung Cancer Spine Metastasis in Rodents Hsp90 Inhibitor Induced Autophagy And Apoptosis In Kevin A Sonn, Sharath S Bellary, Chawon Yun, Sohaib Z Osteosarcoma Cells Hashmi, John Nelson, Michael S Nickoli, Jason H Ghodasra, Masaki Mori Abhishek Kannan, Amruta Ashtekar, Christian Park, Anjan Ghosh, Stuart Stock, Erin L Hsu, Wellington K Hsu Poster No. 1941 Oncolytic Measles Virus (MV) expressing Poster No. 1932 Sodium Iodine Symporter Gene as a Therapy for Myc Target 1 (MYCT1) Gene is a Novel Target of Neurofibromatosis Type I Associated Tumors TGF-β Signaling to Promote Differentiation of David Deyle, Scott Riester, Kah-Whye Peng, Dusica Chondrosarcoma Cells Babovic--Vuksanovic Yuhei Yahiro, Shingo Maeda, Naohiro Shinohara, Kanehiro Matsuyama, Ichiro Kawamura, Takao Setoguchi, Poster No. 1942 Satoshi Nagano, Masahiro Yokouchi, Yasuhiro Ishidou, Epigenetic Regulation of Metastatic Osteosarcoma Setsuro Komiya Cells with HDAC Inhibitor Xiaodong Mu, Daniel Brynien, Johnny Huard, Kurt Weiss 144 Poster No. 1943 Poster No. 1952 Preclinical Activity Of KPT-330, An Inhibitor Of Crm1/ Shear Wave Elastography _ A Promising Diagnostic xpo1, In Several Models Of Sarcoma Subtypes Tool For Evaluating Tendon Regeneration In Chronic Robert Nakayama, Yi-Xiang Zhang, Ewa Sicinska, Tendinopathy George D Demetri, Andrew J Wagner Valentin M Quack, Matthias Gatz, Timm Dirrichs, Marcel Betsch, Björn Rath, Christian Lüring, Markus Tingart, Poster No. 1944 Simone Schrading GSK-3 Inhibitor Inhibits Cell Proliferation And Induces Apoptosis In Human Osteosarcoma Cells Poster No. 1953 Hideki Nishimura Increased Transverse Carpal Ligament Stiffness in Pianists Poster No. 1945 Christiane Mhanna, Tamara L Marquardt, Zong-Ming Li A Platelet Aggregation-inducing Factor Podoplanin Is Highly Expressed In Metastatic Legions Of PS2 Diagnostic Imaging - Biomarkers Osteosarcoma Hiroharu Oki, Mika Kato Kaneko, Satoshi Ogasawara, Yuta Poster No. 1954 Tsujimoto, Xing Liu, Masato Sugawara, Yuya Takakubo, Noninvasive, Sensitive, And Real-time Detection Takashi Tsuchiya, Michiaki Takagi, Yukinari Kato Of Adamts5 Mrna Induction During Injury Induced Osteoarthritis In Vivo Poster No. 1946 Hongchuan Yu, Yupeng Chen, Qian Chen Targeting Cancer Stem Cell Marker miR302C in Human Chondrosarcoma Determines the Antiproliferative Poster No. 1955 Activity of Proline Rich Polypeptide 1 Evaluation of Anti-interleukin-6 Therapy In Patients Karina Galoian, Amir Qureshi, H.T Temple With Rheumatoid Arthritis Using FDG-PET/CT Koichi Okamura, Yukio Yonemoto, Takahito Sudo, Chisa Poster No. 1947 Okura, Kenji Takagishi Amino Acid Deprivation Therapy Targeting Metabolic Pathway Dysregulated in Bone and Soft Tissue Poster No. 1956 Sarcomas In Vivo Evaluation Of Arthritis By Mmp Activatable Eisuke Kobayashi, Daisuke Kubota, Yongji Kim, Probe In A Rat Mia-induced Model Shigehisa Kitano, Akira Kawai Mio Udo, Ichiro Sekiya, Kunikazu Tsuji, Nobutake Ozeki, Yusuke Nakagawa, Toshiyuki Ohara, Ryusuke Saito, Poster No. 1948 Katsuaki Yanagisawa, Takeshi Muneta Middle-term Clinical Outcome of Myxoid Liposarcoma and Efficacy of Hyperthemia with Radiotherapy Poster No. 1957 Nobuhiko Yokoyama, Tomoya Matsunobu, Akira Correlation of T1ρ and T2 Relaxation Times Values with Nabeshima, Mihoko Hatano, Yuko Fujiwara, Keiichiro Iida, Glycosaminoglycan and Water Content of Articular Yoshihiro Matsumoto, Jun-ichi Fukushi, Katsumi Harimaya, Cartilage Yukihide Iwamoto Ali Hosseini, Yang Wang, Martin Torriani, Alan J Grodzinsky, Guoan Li Poster No. 1949 The Emerging Role of p38 for expression of Sclerostin PS2 Diagnostic Imaging - Bone in Giant Cell Tumor Jocelyn Compton, Dawn Maldonado, Hyunwoo Kang, Poster No. 1958 Jungho Back, Lee Song, Heon Goo Lee, Francis Y Lee C omparison Of Gd-DTPA-BMA Vesus Gd-DOTA Gadolinium Retention In Human Bone Tissue Poster No. 1950 Toshihiro Akisue, Hitomi Hara, Teruya Kawamoto, Takaki A Potential Biomarker Predicting Sensitivities of Maeda, Hajimu Goto, Yasuo Onishi, Kazuro Sugimura, Synovial Sarcoma Cells to a Selective c-MET Inhibitor, Masahiro Kurosaka INC280

Yoshinori Imura, Hidetatsu Outani, Kenichiro Hamada, Poster No. 1959 POSTERS Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Variability in Fluoroscopic Image Acquisition during Itoh, Hideki Yoshikawa, Norifumi Naka Operative Fixation of Ankle Fractures at an Academic Institution PS2 Diagnostic Imaging - Tendons, Ligaments Dorothy Y Harris, Ronald W. Lindsey

Poster No. 1951 Poster No. 1960 MRI Derived Parameters Of Volume And Signal Methods And Guidelines For Ex-vivo Dxa Scanning Intensity Predict Clinical, Functional And Patient- Brian T Graham, Jessica Penman, Daniel Whitney, oriented Outcome Measures Following ACL Christopher Modlesky, Jeremi Leasure, Jenni Buckley Reconstruction Alison M Biercevicz, Matthew R Akelman, Paul D Fadale, Poster No. 1961 Michael J Hulstyn, Robert M Shalvoy, Gary J Badger, Glenn X-ray Reliability to Detect Spinous Process Fractures A Tung, Heidi L Oksendahl, Braden C Fleming after Placement of Interspinous Process Spacer William F Lavelle, Mark Palumbo, Aaron Bianco, Richard Tallarico, Mauricio Valdes 145 Poster No. 1962 Poster No. 1972 Blumensaat-Epiphyseal Containment of the Knee Analysis Of Mechanical Strength In Talus Using (BECK): A New Radiological Guide to Determine CT-osteoabsorptiometry; In Vivo Study Patellar Height Yusuke Hara, Kazuya Ikoma, Masamitsu Kido, Kan Imai, Daniel Boguszewski, Nirav Joshi, Edward Cheung, Agneish Yukiko Tokumoto, Masahiro Maki, Keiichiro Ueshima, Dutta, Richard Bowen, William Oppenheim, Jennifer Beck Daisaku Tokunaga, Nozomu Inoue, Toshikazu Kubo

Poster No. 1963 Poster No. 1973 The Role of Bone Marrow Edema in the Prognosis for Discrimination of Connective Tissue Cell Types Subchondral Insufficiency Fracture of the Hip Joint by Infrared Spectroscopic Imaging Satoshi Ikemura, Taro Mawatari Padraig B Glenn, Nicholas J Caccese, Theresa Freeman, Deepa Shankar, Nancy Pleshko Poster No. 1964 Femoral Geometry and BMD in Patients With Hip Poster No. 1974 Osteoarthritis and Those With Hip Fracture During Quantitative Analysis Of T2 Relaxation Times of the a Six-year Follow-up Knee Cartilage 3 Years After ACL Reconstruction Jukka Hirvasniemi, Yaw Adjei, Jérôme Thevenot, Mikko Ji Hoon Bae, Ali Hosseini, Yang Wang, Naveen Jasty, Martin Määttä, Pasi Pulkkinen, Risto Ojala, Raija Korpelainen, Torriani, Thomas J Gill, Alan J Grodzinsky, Guoan Li Simo Saarakkala, Timo Jämsä Poster No. 1975 Poster No. 1965 Is the Contralateral Hip at Risk in Patients with Bone Quality Of The Calcaneus 5 Years After Unilateral Symptomatic Cam FAI? A Quantitative T1ρ Total Knee Arthroplasty MRI Study Yoshinori Ishii, Hideo Noguchi, Junko Sato Scott McGuffin, Gerd Melkus, Kawan Rakhra, Arturo Cardenas-Blanco, Paul E Beaulé PS2 Diagnostic Imaging - Cartilage (Articular and Meniscal) Poster No. 1976 A Trial To Detect Early Degenerative Changes Of Poster No. 1966 Rabbit Knee Cartilage In Vivo Using MR Imaging In-vitro and In-vivo Imaging of Mmp Activity in With A Double-contrast Agent Cartilage and Joint Injury Shigeki Hayashi, Kazuya Ikoma, Masamitsu Kido, Yusuke Tomoaki Fukui, Elizabeth Tenborg, Jasper H. N. Yik, Hara, Yuji Arai, Masazumi Saito, Tetsuro Yamasaki, Tsuyoshi Dominik R Haudenschild Sukenari, Okihiro Onishi, Keiichiro Ueshima, Osam Mazda, Toshikazu Kubo Poster No. 1967 Reliability of Radial MRI with Biochemical and Poster No. 1977 Morphological MR Sequences in Painful Hips: Development Of A New Tool To Predict Outcome Of Comparison to Arthroscopic Findings Hip Arthroscopy: Worms- Whole Organ Magnetic Hidetoshi Hamada, Takashi Nishii, Masaki Takao, Takashi Resonance Score Sakai, Hideki Yoshikawa, Nobuhiko Sugano Helen Anwander, Nathan Sacevich, Kawan Rakhra, Mark Schweitzer, Paul E Beaulé Poster No. 1968 Diffusion Rate And Equilibrium Partition Of An Anionic Poster No. 1978 Contrast Agent Are Different In Cartilage And Meniscus T2 Quantitative Magnetic Resonance Imaging Juuso T Honkanen, Mikael Turunen, Virpi Tiitu, Jukka S Identifying Femoral Head Cartilage Degeneration Jurvelin, Juha Töyräs As A Result Of Corticosteroid Treatment And POSTERS Osteoporosis Poster No. 1969 Shigeo Hagiwara, Junichi Namakura, Atsuya Watanabe, Is Worms A Suitable Analysis To Quantify The Status Shunji Kishida, Takanori Omae, Shuichi Miyamoto Of Osteoarthritis? Heide Boeth, Felix Eckstein, Benedetta Rigoni, Gerd PS2 Diagnostic Imaging - Muscle, Nerve, Vasculature Diederichs, Arne Schlausch, Wolfgang Wirth, Tobias Jung, Georg Duda Poster No. 1979 C an Soft Tissues Structures Differentiate Poster No. 1970 Between Fai And Dysplasia? Effect Of Soft Tissue On Ultrasound Characterization Anne Le Bouthillier, Kawan Rakhra, Jae-Jin Ryu, Paul E Of Articular Cartilage Degeneration: Experimental Beaule, Ryan Foster Study With Clinical Ultrasound Device Wajiha Bano, Jana Podlipská, Joonas Oinas, Sakari Karhula, Poster No. 1980 Simo Saarakkala Variance of Cervical Vertebral Artery Measured by CT Angiography and Its Influence on C7 Pedicle Anatomy Poster No. 1971 Norimitsu Wakao, Mikinobu Takeuchi, Mitsuhiro Kamiya, Multivariate Analysis of OCT Signal Enhances Atsuhiko Hirasawa, Katsuhisa Kawanami, Keiji Sato, Prediction of Articular Cartilage Health Masakazu Takayasu Pia H Puhakka, Nikae C.R. te Moller, Isaac O. Afara, Harold Brommer, Virpi Tiitu, Tuomas Viren, Jukka S. Jurvelin, Juha 146 Töyräs PS2 Diagnostic Imaging - Novel and Functional Imaging, Poster No. 1994 Artifacts In Vivo Drug Release Behavior And Bone Biocompatibility Of Doxorubicin-loaded Tissue- Poster No. 1981 engineered Scaffold Three-dimensional, Sub-micron Imaging Of Bone Ming Sun, Muwan Chen, Miao Wang, Jakob Hansen, Dang And Fluorescent Markers Of Bone Formation At The Q.S. Le, Anette Baatrup, Frederik Dagnaes-Hansen, Jan Bone-implant Interface Rölfing, Jonas Jensen, Helle Lysdahl, Mogens Johannsen, Amanda R Bouman, Floor M Lambers, Erin N Litts, Jørgen Kjems, Cody E. Bünger Christopher J Hernandez Poster No. 1995 Poster No. 1982 Decelluarized Tendon Slices With An Inductive Calcaneal Impingement on the Achilles Tendon Microenvironment For Enhancing Rat Tendon-derived and the Effect of Heel Lifts Quantified Using Stem Cells Proliferation And Tenogenic Differentiation a Novel, Non-invasive Tool Liangju Ning, Yajing Zhang, Yi Zhang, Quan Qing, Yanlin Ruth Chimenti, Michael Richards, Ibrahima Bah, Jiang, Jieliang Yang, Jingcong Luo, Tingwu Qin Samuel Kwak, Jeff Houck, Samuel Flemister, John Ketz, Mark Buckley Poster No. 1996 The Acute and Chronic Biologic Response following Poster No. 1983 Noninvasive Anterior Cruciate Ligament Rupture 3D Molecular And Morphological Characterization compared to Surgical Transection as Models for Post- of the Intervertebral Disc Using Affinity- And Traumatic Osteoarthritis (PTOA) Exclusion-based Contrast-enhanced MicroCT Tristan Maerz, Perry Altman, Michael Kurdziel, Michael Tristan Maerz, Michael Newton, Shannon Timmons, Newton, Kyle Anderson, Kevin Baker, Howard Matthew Nathan Delaney, Michael Pirrone, Daniel Park, Kevin Baker Poster No. 1997 Poster No. 1984 Cholesterol Homeostasis mediates Hedgehog Use of Dual-energy X-ray Absorptiometry Region- Signaling in Osteoarthritis Free Analysis (DXA-RFA) to Resolve Bone Remodeling Shabana A Ali, Mushriq Al-Jazrawe, Heather Whetstone, around Non-Standard Prosthesis Designs Benjamin Alman Richard M Morris, Lang Yang, Miguel A Martin-Fernandez, Jose M Pozo, Alejandro Frangi, Marci Maheson, J. Mark Poster No. 1998 Wilkinson Diet Induced Obesity Leads to Increased Expression of Adipokines by Intraarticular tissues and Poster No. 1985 Osteoarthritis-like changes in the Rat Knee In Vivo Measurement of Vertebral Endplate Kelsey H Collins, David A Hart, Raylene A Reimer, Walter Surface Area in the Whole Spine Herzog Maho Kishimoto, Koji Akeda, Koichiro Murata, Akihiro Sudo, Alejandro A Espinoza Orias, Nozomu Inoue Poster No. 1999 Epigenetic Analysis of Adipose Stem Cells in Obesity Identifies Dysregulation of Critical Pathways in Musculoskeletal Regeneration and Disease La te Breaking Posters Dianne Little, Chia-Lung Wu, Reid D’Amico, David Corcoran, Simon Gregory, Farshid Guilak

Poster No. 2000 Poster No. 1992 Biomechanical Analysis of Tibiofemoral Contact A Biphasic Apatite/ Sulphate Bone Substitute and Pressures After Novel Repair of Meniscus Horizontal Osteoblast Cell Factory Harvested Bone Active Cleavage Tears Proteins Induce TransdifferentiationO f Skeletal Muscle Brandon Beamer, Kempland C. Walley, Stephen Okajima, Cells Ohan Manoukian, Miguel Perez-Viloria, Joseph P

D eepak Raina, Ankur Gupta, Werner Hettwer, Michael DeAngelis, Arun J Ramappa, Ara Nazarian POSTERS Petersen, Martin Mc Nally, Magnus Tagil, Ming Hao Zheng, Ashok Kumar, Lars Lidgren Poster No. 2001 Crosstalk between Sensory Neuropeptides Regulating Poster No. 1993 Heterotopic Ossification inT endon A Biphasic Apatite/Sulphate Injectable Bone Ceren Tuzmen, Lee Weiss, Phil G Campbell Substitute As a Carrier for Bone Morphogenic Protein-2 and Zoledronic Acid: In- Vitro and In-Vivo Poster No. 2002 Analysis Biaxially Aligned Tendon-derived Matrix-Poly(Ε- Deepak Bushan Raina, Hanna Isaksson, Werner Hettwer, caprolactone) (PCL) Electrospun ScaffoldsF or Rotator Ashok Kumar, Magnus Tagil, Lars Lidgren Cuff Tendon Tissue Engineering Tiffany Tseng, Sean Meehan, Abby Chainani, Steven B. Orr, Christopher L. Gilchrist, Dianne Little

147 Poster No. 2003 Poster No. 2012 Delivery of Recombinant Indian Hedgehog Protein Co-transplantation Of VEGF-transfected Adipose to the Healing Patellar Tendon Enthesis Does Not Derived Stromal Cells To Enhance Bone Regeneration Improve Biomechanical Outcomes in a Murine Model And Neovascularization From Bone Marrow Stromal Steven D Gilday, E. Chris Casstevens, Heather M Powell, Cells Keith Kenter, David L Butler, Jason T Shearn Mi Lan Kang, Ji Eun Kim, Chan Hee Park, Gun-Il Im

Poster No. 2004 Poster No. 2013 Costamere Remodeling And Interstitial Reactions In An T ip Apex Distance May Not Be Appropriate To Predict Experimental Model Of Tendon Release In Sheep The Risk Of Cutout Of Helical Neck Blade Martin Flück, Severin Ruoss, Christoph Möhl, Brigitte von Kun-Jhih Lin, Jeu-Ying Li, Hung-Wen Wei, Kang-Ping Lin, Rechenberg, Mario C Benn, Karl Wieser, Dominik C Meyer, Pei-Yuan Lee Christian Gerber Poster No. 2014 Poster No. 2005 In Vivo Measurement of Two-Dimensional Strain in Wnt-beta-Catenin Controls The Chondrocyte To Adjacent Human Intervertebral Discs during Flexion Osteoblast Lineage Transition In Endochondral Bone Woong Kim, Luyao Cai, David McMillan, Gregory Tamer, Formation Corey Neu Kathryn S Cheah, Horace SW Tsang, Kwok Yeung Tsang, Danny Chan, Yingzi Yang Poster No. 2015 To Excise Or Not To Excise: Raman Spectroscopy To Poster No. 2006 Detect Peripheral Nerve Damage In Humans Controlling for Tissue Age During Raman Spectroscopy Katherine E Cilwa, Tiffani Slaughter, Eric A Elster, Benjamin and Nanoindentation to Assess Changes with Scl-Ab K Potter, Jonathan A Forsberg, Nicole J Crane Therapy, Mouse Aging, and Osteogenesis Imperfecta Benjamin P Sinder, William Lloyd, Joseph Salemi, Joan Poster No. 2016 Marini, Michelle Caird, Michael Morris, Kenneth M Kozloff Functionalized Polyethylene Glycol (PEG) and Poly(trimethylene carbonate) (PTMC) Block Poster No. 2007 Copolymers Demonstrate High Adhesion Strength for Pge2 Receptor Subtype 1 (ep1) Down Regulation Intervertebral Disc Repair Enhances Periosteal-derived Mesenchymal Stem Cell Rose Long, Stijn G Rotman, Dirk W Grijpma, James C (pdmscs) Differentiation And Accelerates Fracture Iatridis Healing Marina E Feigenson, Jennifer Jonason, Hani E Awad, Poster No. 2017 Alayna Loiselle, Regis J O’Keefe The Effect of Dosing and Cryopreservation on Efficacy and Safety of a Novel Cell Therapy for Degenerative Poster No. 2008 Disc Disease Using a Porcine Model: Sub-Acute and Chemokine Receptor Mutated In All Affected Chronic Timepoints Members of a Large Multigeneration Family with Lara I Silverman, Galina Dulatova, Kavita Gupta, Terry DDH Affects Acetabular Morphology In the CX3CR1 Tandeski, Antwain Howard, Subba Chintalacharuvu, Knockout Mouse Kevin Foley Hind Sawan, Theresa Freeman, Javad Parvizi, George J Feldman Poster No. 2018 Analyzing The Cellular Contribution Of Periosteum Poster No. 2009 To Fracture Healing Using A Membrane-targeted A Genome-Wide Association Study of Osteolysis Tdtomato Transgenic Mouse Model POSTERS Following Total Hip Arthroplasty Tao Wang, Daniel D Bikle, Xudong J Li, Alicia Menendez Scott J MacInnes, Anne-Marie Fenstad, Kallia Panoutsopoulou, Lorraine Southam, Geir Hallan, Havard Poster No. 2019 Dale, Ove Furnes, Eleftheria Zeggini, J. Mark Wilkinson Does Taper Size Have an Effect on Taper Damage in Retrieved Total Hip Devices? Poster No. 2010 Genymphas B Higgs, Daniel W MacDonald, Antonia F A Whole Genome Association Study of Susceptibility to Chen, Gregg R Klein, Brian R Hamlin, Gwo-Chin Lee, Heterotopic Ossification AfterT otal Hip Arthroplasty Michael A Mont, Harold E Cates, Arthur L Malkani, Scott J MacInnes, Kallia Panoutsopoulou, Lorraine Matthew J Kraay, Jeremy L Gilbert, Clare M Rimnac, Steven Southam, Eleftheria Zeggini, J. Mark Wilkinson M Kurtz

Poster No. 2011 Poster No. 2020 Phosphate Restriction Leads to Global Inhibition of The Effect of Simulated Inflammatory Conditions on Mitochondrial Oxidative Function in Fracture Healing the Corrosion and Fretting Corrosion of CoCrMo alloy Amira I Hussein, Serkalem Demissie, Kyle Lybrand, Heather Yangping Liu, Jeremy L Gilbert Matheny, Brenna Hogue, Anthony De Giacomo, Louis Gerstenfeld

148 Poster No. 2021 Poster No. 2030 Patient Outcomes Following Revision Total Knee Imaging Collagen-associated Water In Bone By Arthroplasty With Total Stabiliser Prostheses Are Magnetic Resonance Imaging And Near Infrared Similar To Those Achieved Following Primary Knee Spectroscopy Arthroplasty: A Longitudinal Cohort Study Mugdha V Padalkar, Eric Greco, Hee Jin Yang, Michale David F Hamilton, Philip Simpson, James T Patton, Colin R Inspiryan, Nancy Pleshko, Chamith S Rajapkse Howie, Hamish RW Simpson, Richard Burnett Poster No. 2031 Poster No. 2022 Functional Neuroplasticity Related With Shoulder IL-10 Ameliorates Titanium-particles induced Proprioception In Patients With Recurrent Shoulder Inflammation through Macrophage Polarization Instability Jianhao Jiang, Joanna Rodriguez, Taylor Oakes, Shang-You H itoshi Shitara, Daisuke Shimoyama, Tsuyoshi Ichinose, Yang Atsushi Yamamoto, Tsutomu Kobayashi, Toshihisa Osawa, Kenji Takagishi Poster No. 2023 A Comparison and Correlation of Clinical Outcome Metrics in Anatomic and Reverse Total Shoulder Arthroplasty Christopher Patterson Roche, Pierre Henri Flurin, Yann Marczuk, Thomas Wright, Diane Johnson, Yassaman Najmabadi, Joseph Zuckerman

Poster No. 2024 The Anatomic Relationship Between The Morphology Of The Greater Tubercle Of The Humerus And The Insertion Of The Infraspinatus Tendon Nimura Akimoto, Taiki Nozaki, Keiichi Akita

Poster No. 2025 Defining the Role of Fibro-Adipogenic Progenitor Cells in Fibrosis and Fatty Infiltration of Muscle After Rotator Cuff Tears Anne Y Ning, Bharat Ravishankar, Mengyao Liu, Hubert Kim, Xuhui Liu, Brian T Feeley

Poster No. 2026 Bacterial Inhibition By Chitosan Coatings Loaded With Silver-decorated Calcium Phosphate Microspheres Jessica Amber Jennings, Jegdish Babu, Diego Velasquez, Daniel Carpenter, Sanjay Mishra, Joel D Bumgardner

Poster No. 2027 Clinical And Histological Predictors Of Heterotopic Ossification In Warfighters From OIF And OEF Brad M Isaacson, Thomas Swanson, Benjamin K Potter, Richard T Epperson, Roy D Bloebaum, Paul F Pasquina

Poster No. 2028 MRI Assessment of Oral CSF1-Receptor Inhibition with PLX3397 for Tenosynovial Giant Cell Tumor/Pigmented

Villonodular Synovitis using Novel Modified RECIST, POSTERS Tumor Volume Scoring, and Tissue Damage Scoring Methods Charles Peterfy, William D. Tap, Julie DiCarlo, Zev A. Wainberg, Chao Zhang, Arthur P. Staddon, Allen Lee Cohn, Geoffrey Shapiro, Igor Puzanov, Eunice L. Kwak, Henry H. Hsu, Paul S. Lin, Sandra Tong, John H Healey

Poster No. 2029 Doxorubicin Induced Oxidative Stress is a Double Edged Sword for Life and Death of Cancers Regulated by p53- Dependent Dual Function of SRC kinase SungWook Seo, Dami Shim, YunSun Lee, YoungJoon Choi

149 AccelLAB Applied Test Systems Bone & Joint Research (BJR) 1635 Blvd. Lionel-Bertrand 154 East Brook Lane 22 Buckingham Street Boisbrend, Québec J7H1N8 Butler, PA 18002 London WC2 N 6ET Canada Phone (724)283-1212 United Kingdom Phone (450)435-9482 Fax (724)283-8670 Phone +44 (0) 20 7782 0010 Fax (450)435-4795 www.atspa.com Fax +44 (0) 20 7782 0995 www.accellab.com www.bjr.boneandjoint.org.uk Applied Test Systems is a leading AccelLAB is a one-stop preclinical CRO manufacturer of process heating Bone & Joint Research is an open access that conducts Regulatory Testing with and material testing equipment. ATS journal indexed in PubMed Central and high-quality safety and efficacy studies manufactures equipment designed for PubMed, and tracked for a 2014 Impact for the evaluation of medical devices Creep and Tensile Testing, Burst Testing, Factor. BJR accepts papers across the and biologics following GLP regulations. Sealant Testing, Asphalt Testing, and a whole spectrum of the musculoskeletal Highly specialized services under one variety of Process Heating applications. sciences. Visit us on booth 333 for a free roof include: study designs, sophisticated Our service department is A2LA USB flash drive and find out more! surgical suites and imaging technology accredited. You can be assured that ATS (incl. CT-Scan, MRI, Radiography and equipment will meet your needs and Bose Corporation µCT), blood assays, histomorphometry, expectations. 10250 Valley View Road histopathology and report production Eden Prairie, MN 55344 by full-staff pathologists. Successfully ATI Industrial Automation Phone (952)278-3070 audited by the FDA in 2012, AccelLAB is 1031 Goodworth Drive Fax (952)278-3071 Fully Accredited by AAALAC and CCAC. Apex, NC 27539 www.bose-electroforce.com Phone (919)772-0115 Active Life Scientific,I nc. Fax (919)772-8259 Your success is our mission at Bose. 32 Anacapa St., Suite D www.ATI-IA.com We provide biomechanical testing and Santa Barbara, CA 93101 bioreactor solutions to leading research Phone (805)770-2600 ATI Industrial Automation’s Multi-Axis institutions worldwide. Our ElectroForce® Fax (805)770-2606 Force/Torque Sensors measure all zero-friction motor technology provides www.activelifescientific.com components of force and torque (Fx, Fy, exceptional performance and simplicity Fz, Tx, Ty, and Tz) and are used in a wide for sterile and non-sterile orthopaedic Active Life Scientific, Inc., creators variety of applications including; robotic applications. Visit our booth to learn of Reference Point Indentation (RPI) surgery, haptics, rehabilitation, and about Bose Access and 3DCulturePro – technology, develops translational tools neurology. Key features include: High the newest solutions from Bose! to measure the material properties overload protection, high-speed output, of bone. This innovative technology span temperature compensation, and Bruker BioSpin enables scientists to measure bone high signal-to-noise ratio. 15 Fortune Drive in situ, both in vivo and ex vivo. The Billerica, MA 01821 flag ship products are BioDent™ and Biomomentum Inc. Phone (978)667-9580 OsteoProbe® RUO (research use only). 970 Michelin Street, Suite 200 Fax (978)667-0985 Laval, Québec H7L5C1 www.bruker.com AMTI Canada 176 Waltham Street Phone (450)667-2299 Being one of the world’s leading Watertown, MA 02472 www.biomomentum.com analytical instrumentation companies, Phone (617)926-6700 Bruker offers advanced preclinical Fax (617)926-5045 Biomomentum provides instruments and imaging solutions for a broad spectrum www.amti.biz services for biomechanical testing. The of application fields, such as cancer Mach-1™ is a mechanical tester designed research, functional and anatomical

E AMTI’s new VIVO™ testing system for compression, tension, shear, and neuroimaging, cardiac imaging and X

HIBITORS dramatically increases simulation torsion testing. It can be configured for orthopedics. The range of techniques realism for orthopaedic research. automatic mapping on articular cartilage includes Magnetic Resonance Imaging, Innovations include six axes with force surfaces through indentation. The micro-CT, 3D optical microscopy and or displacement control, expanded Arthro-BST™ is a medical device for the optical imaging. ranges of motion, and patented Virtual measurement of compression-induced Soft Tissue control. Digital Fixturing™ streaming potentials of articular cartilage simulates joint malalignment and during arthroscopy. adverse postsurgical outcomes. VIVO tests implants or cadaveric specimens from any joint in the body.

150 C-Motion Inc. Cleveland Clinic BioRobotics Core Elsevier BV 20030 Century Blvd, Suite 104A 9500 Euclid Ave., ND-2O Radarweg 29 Germantown, MD 20874 Cleveland, OH 44195 Amsterdam 1043 NX Phone (301)540-5611 Phone (216)399-6743 Netherlands Fax (301)540-5613 http://mds.clevelandclinic.org/services/ Phone +31204852308 www.c-motion.com biorobotics.aspx www.elsevier.com

C‐Motion provides the world’s leading The Cleveland Clinic BioRobotics Core is ELSEVIER is a leading publisher of health research tools for understanding the a center of excellence for biomechanical science publications, advancing medicine mathematically complex nature 3D testing of biological structures and by delivering superior reference movements. Our software Visual3D biomaterials. We provide robotic testing information and decision support tools is hardware independent, marker set capabilities for tissues, joints, and to doctors, nurses, health practitioners independent and provides clinically multi-articular units, such as knees, hips, and students. With an extensive media validated consistent results from any shoulders, foot/ankle complexes, and spectrum — print, online and handheld, motion capture data which makes spines. We also develop and sell robotic we are able to supply the information it a compelling product for clinical testing systems using our simVITRO you need in the most convenient format. assessments, visualizing 3D data and software. other applications. Faxitron Collagen Solutions US Inc. 3440 E. Britannia Drive, Suite 150 Cambridge Polymer Group 5941 Optical Court Tucson, AZ 85706 56 Roland Street, Suite 310 San Jose, CA 95138 Phone (520)399-8180 Boston, MA 02129 Phone (408)960-2205 Fax (520)399-8182 Phone (617)629-4400 Fax (866)935-9288 www.faxitron.com Fax (617)629-9100 www.collagensolutions.com www.campoly.com As the world’s only fully vertically Collagen Solutions US Inc. provides integrated and dedicated cabinet Cambridge Polymer Group, Inc. is a a highly skilled team offering both X-ray company, Faxitron is the industry contract research laboratory specializing standard and customized collagen raw standard. Faxitron offers compact, fully- in materials and products. Our services material supply of ultra-purified soluble shielded digital imaging systems with the range from routine analytical testing to collagen, powders, and dispersions in highest resolution (up to 100 lp/mm) and new product research and development. addition to expert development services. the largest field of view in the market. We provide a high-quality rapid Contract manufacturing is done under turnaround resource with our multi- BSI certified ISO 13485 and produces Flexcell International Corporation disciplined experienced team in all sizes product used in FDA and CE approved 2730 Tucker Street, Suite 200 of projects. devices worldwide. Burlington, NC 27215 Phone (800)728-3714 CellScale Biomaterials Testing Delsys, Inc. Fax (919)732-5196 3B – 572 Weber Street N. 23 Strathmore Road www.flexcellint.com Waterloo, Ontario N2L 5C6 Natick, MA 01760 Phone (519)342-6870 Phone (508)545-8200 Flexcell International Corporation www.cellscale.com Fax (508)975-4551 specializes in designing and www.delsys.com manufacturing products to apply CellScale manufactures biomaterial mechanical loads, including tension, and mechanobiology test systems. Our Delsys is a world leader in the design, compression, and fluid shear, to cells mechanical test systems are specifically manufacture and marketing of a in monolayer and 3D culture. Flexcell designed for biomaterials testing and broad portfolio of high-performance has high-throughput culture plates, incorporate temperature-controlled Electromyography, physiological/ equipment for making 3D cell-seeded media baths, image capture and analysis biomechanical sensors used in constructs, software for analyzing 3D software, and a range of gripping movement measurement research gel compaction, microscope devices mechanisms. Our cell culture systems and education. Our wired and wireless for viewing real-time response to enable mechanically active environments sensors and software solutions are mechanical load, and a state of the art in 2D or 3D. designed to meet the needs of our broad microfluidic pump. HIBITORS

customer base in over 85 countries. X E

151 H istion iovera° health Kubtec Digital X-ray 2615 W. Casino Road 1600 Seaport Blvd., Suite 450 270 Rowe Avenue, Unit E Everett, WA 98204 Redwood City, CA 94063 Milford, CT 06461 Phone (425)347-0439 Phone (650)465-9709 Phone (203)364-8544 Fax (425)353-3604 www.ioverahealth.com Fax (203)255-7494 www.histion.com www.kubtec.com ISIS Services Histion specializes in evaluation of 1031 Bing Street Kubtec’s DIGIMUS digital X-ray system medical devices (including drug/device San Carlos, CA 94070 offers high-resolution small animal and biologic/device combinations) with a Phone (510)704-0140 imaging with BMD measurements proven track record of success providing www.isisservices.com available in seconds. Rapid acquisition, data to support regulatory submissions. automatic calibration, a 12x15 Services include consulting, design and With over 25 years of experience in cm detector and 5X geometric execution of preclinical studies, soft and experimental surgery, ISIS Services is magnification, and ports for anesthesia hard tissue histology, precision cutting/ a leader in preclinical medical device and monitoring devices makes DIGIMUS grinding, immunohistochemistry, contract research. ISIS is fully equipped the ideal tool for animal research. histopathology, histomorphometry, to handle all of your needs from research Available as compact bench-top or micro-CT analysis and mechanical and development to non-GLP and GLP portable system. testing. studies. Our state-of-the-art facility consists of four surgical suites with Lifecore Biomedical Instron imaging systems including a cath lab, 3515 Lyman Blvd 825 University Avenue c-arms, ultrasound, endo and lap towers. Chaska, MN 55318 Norwood, MA 02062 Phone (952)368-6321 Phone (800)564-8378 The Japanese Orthopaedic Association Fax (952)368-4278 Fax (781)575-5725 2-40-8 Hongo, Bunkyo-ku www.lifecore.com www.instron.com Tokyo 113-8418 Japan Lifecore Biomedical, LLC, specializes Instron® TGT instruments are uniquely Phone +81-3-3816-3671 in aseptic filling and manufacturing of designed for all aspects of tissue Fax +81-3-3818-2337 hyaluronan by fermentation and recently engineering & regenerative medicine. www.joa.or.jp introduced Corgel™ BioHydrogel kits to Test applications range from condition & the research community. Hyaluronan engineer developing tissues to providing The Japanese Orthopaedic Association is used and Corgel is being evaluated an in vitro testbed for drugs and cell was founded in 1926 (Year 15 of the in applications that range from therapy development. Instron TGT Taisho era) in order to promote studies ophthalmology and tissue engineering provides customers with comprehensive of orthopaedics, presentation of study to orthopedics, wound healing and solutions for all their research, quality results, and to strengthen contact and aesthetics, along with several others. and testing requirements. cooperation among organizations and individuals specializing in this Materialise IOP Publishing discipline. Our goal is to facilitate the 44650 Helm Court 150 S. Independence Mall W., Suite 929 maintenance and improvement of bone Plymouth, MI 48170 Philadelphia, PA 19106 and joint function. To achieve this, it Phone (734)259-6445 Phone (215)627-0880 will be necessary to produce medical Fax (734)259-6441 Fax (215)627-0879 specialists who are adept at diagnosis http://biomedical.materialise.com/ www.ioppublishing.com and treatment, including conservative treatments such as therapeutic exercise, Materialise has extensive experience in IOP Publishing is an international, not- as well as pharmacotherapeutics and medical imaging processing with the for-profit, learned society publisher. We surgery. Mimics Innovation Suite, which provides E are a world leader in scientific publishing surgeons, researchers and engineers with X

HIBITORS and the electronic dissemination of peer- the most detailed and precise anatomical reviewed scientific research. Stop by our models available. The MIS is a powerful, booth for a sample copy of one of our user‐friendly image processing software renowned journals, such as Biomedical that translates medical images to CAD Materials (www.iopscience.iop.org/bmm) models, STL files or FEA meshes and Biofabrication (www.iopscience.iop. within minutes. org/bf).

152 Micro Photonics, Inc. MTS Systems Corporation National Institute of Arthritis and 4972 Medical Center Circle 14000 Technology Drive Musculoskeletal and Skin Diseases Allentown, PA 18106 Eden Prairie, MN 55344 1 AMS Circle Phone (610)366-7103 Phone (952)937-4000 Bethesda, MD 20892-3675 Fax (610)366-7105 Fax (952)937-4515 Phone (301)495-4484 www.microphotonics.com www.mts.com Fax (301)718-6366 www.niams.nih.gov Micro Photonics, and partner Bruker Orthopaedic researchers and MicroCT are leading the advancement manufacturers worldwide depend The mission of the National Institute of in high resolution micro-CT solutions on MTS to provide test systems that Arthritis and Musculoskeletal and Skin for bone, biomaterials, orthopedics, and offer precision control for testing and Diseases is to support research into the other life science research with a focus simulation. MTS delivers innovative causes, treatment, and prevention of on bone morphology and BMD. The solutions for kinematics research, trauma arthritis and musculoskeletal and skin SkyScan product line meets the high- studies, biomaterial testing and more. By diseases; the training of basic and clinical resolution and versatility required for any choosing MTS, you gain a partner who scientists to carry out this research; and demanding research laboratory. understands how to optimize test design the dissemination of information on and speed development. research progress in these diseases. The MotionMonitor 3711 North Ravenswood, Suite 150 N2 Biomedical Northern Digital Inc. (NDI) Chicago, IL 60613 One Patriots Park 103 Randall Drive Phone (773)244-6470 Bedford, MA 01730 Waterloo, Ontario N2V 1C5 Fax (773)244-6473 Phone (781)275-2727 Canada www.themotionmonitor.com www.n2bio.com Phone (877)634-6340 Fax (519)884-5184 Innovative Sports Training, Inc is proud N2 Biomedical is a leading provider www.ndigital.com/lifesciences to provide The MotionMonitor®, a fully- of surface modification services for integrated 3D motion analysis system for improving the performance of medical For over 30 years, Northern Digital use in biomechanical, orthopaedic, and devices. We offer customized coatings Inc. (NDI) has been a global-leading clinical applications. Data from various and surface treatments to meet a variety innovator and manufacturer of advanced kinematic tracking systems, EMG, force of performance improvement needs, 3D measurement systems. Our high- plates, video, and other analog devices including reduced wear, enhanced bone speed Optotrak Certus optical tracker are collected through one platform, in-growth, higher lubricity, antimicrobial captures the position and complex synchronized, and presented in real-time. properties, radiopacity, and electrical motion of a specimen under applied CT/MRI registration capabilities offer conductivity/insulation. force, recording real-time 3D/6DOF subject-specific models and tracking of measurements with exceptional accuracy internal landmarks. National Disease Research Interchange and spatial resolution. (NDRI) MPI Research 1628 John F. Kennedy Blvd, Novel Inc. 54943 N. Main Street 8 Penn Center, 15th Floor 964 Grand Avenue Mattawan, MI 49071 Philadelphia, PA 19103 St. Paul, MN 55105 Phone (269)668-3336 Phone (215)557-7361 Phone (651)221-0505 Fax (269)668-4151 www.ndriresource.org Fax (651)221-0404 www.mpiresearch.com www.novelusa.com The National Disease Research MPI Research is a full-service Interchange (NDRI) is a 501(c)(3) not- Novel is quality in pressure distribution preclinical CRO. Our experienced for-profit, NIH-funded organization measurement and manufactures staff offers Sponsors extensive that provides project-driven human pressure measurement systems that cardiovascular, orthopedic, neurologic, biospecimen service to academic and are accurate and reliable for all testing gastroenterological, urologic, wound corporate scientists. NDRI has over 30 requirements. Novel offers three different healing, drug delivery, and medical years of experience globally distributing systems; the emed platform, the pedar device capabilities, within industry human biospecimens for research. in-shoe, and the pliance system, which leading surgical facilities. Learn more Our extensive recovery network has measures intraarticular pressure at HIBITORS about how we can exceed your the expertise to provide anatomical the patella and tibia, hand/gripping X E expectations at www.mpiresearch.com. structures, organs, and tissues with pressures, and much more. Please visit annotated data. www.novelusa.com for more detailed information.

153 OsteoMetrics Pre-Clinical Research Services, Inc. Qualisys Motion Capture System 1240 Clairmont Road, Suite 100 1512 Webster Court 1630 Old Deerfield Road, #206 Decatur, GA 30030 Fort Collins, CO 80524 Highland Park, IL 60035 Phone (404)276-6558 Phone (970)232-1122 Phone (847)945-1411 Fax (404)876-6004 Fax (970)232-1126 Fax (224)636-9832 www.osteometrics.com www.preclinicalresearch.com www.qualisys.com

OsteoMetrics, Inc., with 300 Pre-Clinical Research Services, Inc., Qualisys Motion System is the leading OsteoMeasure systems worldwide, has located in Ft. Collins, Colorado, mocap company that can manufacturer been redefining Bone Histomorphometry provides pre-clinical services including: and supply high quality (12mg / 300 hz, since 1989. OsteoMeasure is now osteoarthritis models, antigen- 3mg / 1100 hz …) digital–optical and available with outstanding live digital induced arthritis, experimental video cameras that operate: outdoors, camera support, on-screen pen surgery (surgical/ medical device in a video mode, has passive and active measurement, thresholding, a complete development, biomaterial implants, markers and traditionally indoors. set of Cortical Bone measurements, a orthopedics, selective catheterization Qualisys technology can be found greatly expanded set of non-specific and angiography), medical imaging: in most clinical labs where accuracy measurements, and a comprehensive MRI, ultrasound/echo, and intra- and precision are equal to outcome GLP validation package. OsteoMetrics is operative fluoroscopy, toxicology and performance and ease of use. Visit us at proud that OsteoMeasure is the system pharmacokinetics. Species include swine, ORS and at www.qualisys.com. of choice of most of the pioneers, the small ruminants, rodents, rabbits, dogs, most prominent and the most published cats. RISystem AG scientists in bone research today. Talstr. 2A Preclinical Surgical Research CH-7270 Davos Platz PharmaLegacy Laboratories Laboratory (PSRL) Switzerland (Shanghai) Co., Ltd Colorado State University Phone +41 81 511 5600 Building 7, 388 Jialilue Road 300 W. Drake Road Fax +41 81 511 5601 Shanghai 201203 Fort Collins, CO 80523 www.risystem.com China Phone (970)682-0079 Phone +86-21-61002280 *2621 http://csu-cvmbs.colostate.edu RISystem AG provides high standard Fax +86-21-61002270 academics/clinsci/surgical-research- implant technology for research purpose. www.pharmalegacy.com laboratory/Pages/default.aspx RISystem implants are exclusively made out of medical grade materials to ensure PharmaLegacy is a preclinical specialty The Preclinical Surgical Research biocompatibility. The small dimensions CRO that has strong track records Laboratory (PSRL) at Colorado State are demanding but with the innovative in services to worldwide companies University conducts pilot and pre-clinical design, the surgical technique is simple committing R & D in therapeutics for research studies with sheep, goats, and easy to learn. To address your study Bone Metabolism/Orthopaedics and rodents, and rabbits as validated animal requirements, the available RISystem kits Tissue Engineering, besides Immune models. The laboratory collaborates can be customized. If you need a new Diseases/Inflammation and Tumor. We with industry and academic institutional implant system, we can give you advice provide quality, timely and cost saving partners to evaluate a wide variety of and/or develop and produce them execution for experiments under GLP medical devices for treatment of spinal, for you. operation and AAALAC certification. orthopaedic, sports medicine and soft tissue conditions. Metabolic disorders RoosterBio, Inc. such as osteoporosis are also commonly 4539 Metropolitan Court studied at the PSRL. Frederick, MD 21704 Phone (301)678-9497 www.roosterbio.com E X

HIBITORS RoosterBio is focused on building a robust and sustainable Regenerative Medicine industry. Our products are high quality, affordable, standardized cells and media, manufactured and delivered in formats that simplify research and product development efforts and accelerate clinical translation and shorten time to market of cell therapies and tissue engineering technologies.

154 S awbones Worldwide Simpleware Ltd. Thelkin AG 10221 SW 188th Street Bradninch Hall, Castle Street Technoparkstrasse 2 Vashon, WA 98070 Exeter EX4 3PL Winterthur 8406 Phone (206)463-5551 United Kingdom Switzerland www.sawbones.com Phone +44 1392 428750 Phone +41-79-8435596 Fax +44 1392 428769 www.thelkin.com SAWBONES WORLDWIDE offers a www.simpleware.com complete range of biomechanical THELKIN offers the next generation composite analogue bones and blocks Simpleware develops world-leading of test systems for the mechanical for mechanical testing. Designed to software solutions for processing and characterization of orthopedic implants simulate the physical properties of converting 3D image data (MRI, CT, and their materials. Our technology human bone; these materials offer a Micro-CT...) into high-quality models provides great precision and flexibility, more reliable test bed for biomechanical suitable for CAD, CAE and 3D Printing. together with significant savings in studies than cadaveric specimens. The software is used in fields such as the time and costs, helping researchers Life Sciences, Materials Science, Industrial and implant manufacturers in the Scanco Medical RE and NDE, to name a few. Easy-to-learn development of safe, effective and PO Box 646 and use, the software offers a robust successful products. Southeastern, PA 19399 bridge between the latest imaging Phone (610)688-1440 technologies and multiple design and THINK Surgical, Inc. Fax (610)688-4976 simulation applications. 47320 Mission Falls Court www.microCT.com Fremont, CA 94539 Tekscan, Inc. Phone (510)249-2318 Scanco Medical (www.microCT.com) 307 West First Street www.thinksurgical.com is the leading global provider of high- South Boston, MA 02127 resolution micro-CT systems from Phone (617)464-4500 Think Surgical, Inc. develops, mouse to man. Scanco also provides Fax (617)464-4266 manufactures, and markets the TSolution contract based scanning services for www.tekscan.com One™ Surgical System which includes: non-destructive scanning applications TPLAN - a 3D planning workstation for at locations in the USA and Switzerland. Tekscan manufactures a broad range pre-surgical planning and TCAT – an GPU-based reconstruction, 3D image of tools for better pressure offloading active robotic, computer-assisted tool for analyses, 3D visualization, Finite Element and enhanced gait analysis. Our precise cavity and surface preparation for Analysis, Image/Data archiving solutions systems use paper-thin, high-resolution joint replacement surgeries, supporting and mechanical loading stage are sensors to measure plantar pressure surgeon selected implants. Visit www. available for all systems. distribution, timing and Center of Force thinksurgical.com for more information. (CoF) trajectory in dynamic evaluations. Simi Reality Motion Systems GmbH The unique information these systems Veterinary Transplant Services, Inc. Max-Planck-Strasse 11 provide helps you objectively validate 215 East Titus Street Unterschleissheim 85716 treatments and improve outcomes. Kent, WA 98032 Germany Phone (253)520-0771 Phone +49-89-321459-0 Test Resources Inc. Fax (253)856-1830 Fax +49-89-321459-16 701 Canterbury Road www.vtsonline.com www.simi.com/en/ Shakopee, MN 55379 Phone (952)944-6534 VTS provides animal-sourced DBM and SIMI® manufactures high-end image- Fax (952)233-3682 other bone graft materials for product based Motion Capture and Analysis www.testresources.net development and pre-clinical studies. Systems for movement and behavior We offer customizable processing & analysis. SIMI® systems are high-speed TestResources is a manufacturer of packaging of graft materials for a wide camera based systems using state of smart design electrodynamic and static variety of animal models. Researchers the art industrial image processing test systems for biomedical/orthopedic can rely on VTS to produce animal tissues technology. Our mission is to develop testing applications. New products processed to their unique product high end image based movement include our electriodynamic planar development or pre-clinical project analysis technology with a clear focus on biaxial and axial/torsion testing system specifications. HIBITORS the user friendliness. Our products and for orthopedic research, a micro-force X E applications range from top research test system for tissue research, and a facilities to practical applications in daily variety of new specimen grips, fixtures activities. Our solutions are tailored to and accessories for biomaterials our customer’s needs and we foster engineering. a very close cooperation with our customers.

155 Vi TRAK Systems Inc. Wake Forest Innovations 91 Water Street, 3rd Floor 575 Patterson Avenue, Suite 550 Charlottetown, Prince Edward Island Winston-Salem, NC 27101 C1A 1A5 Canada Phone (336) 713-1111 Phone (902)626-4248 www.wakepreclinical.com/ Fax (902)626-3781 http://stepscan.com/ Wake Forest Innovations commercializes the great ideas, discoveries and ViTRAK Systems Inc. has developed a capabilities of Wake Forest Baptist Medical pressure sensitive flooring system with Center. It helps to accelerate research & sophisticated footprint analytic development through quality preclinical software for gait research/analysis. testing of medical devices, surgical Branded Stepscan™ the technology procedures and therapeutics, taking measures under foot pressure distribution advantage of the extensive experience and other movement parameters of its internationally renowned scientists, (stride and speed of movement) other veterinarians and surgeons. applications include security/sports training, medicine, clinical drug trials and Wiley various forms of research. 350 Main Street Malden, MA 02148 VOLMO Phone (877)762-2974 45 Stoney Lane Fax (800)597-3299 Newbury RG14 2NG www.wiley.com United Kingdom Phone +91 0755 4064049 Wiley is the leading society publisher. http://volmopl.com We publish on behalf of more societies and membership associations than VOLMO is a medical image processing and anybody else, and offer libraries and modelling software company committed individuals 1250 online journals, to application and utilization of advanced thousands of books and e-books, reviews, image processing techniques and open reference works, databases, and more. For source libraries to develop an innovative more information, visit www.wiley.com, software platform for converting 3D scan or our online resource: onlinelibrary.wiley. data (CT/MRI/US) into surface (STL) and com. volume meshes for finite element (FE)/ computational fluid dynamics (CFD) analysis. E X HIBITORS

156 EXHIBIT HALL MAP TION MA INFOR

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157 158 SUNDM AY, arch 29, 2015 ConT.

P rofessional Advancement Total Hip & Knee Replacement: Session: Finding a Partner Clinical Perspectives and in Research Biomechanics 4:45m P -6:00Pm 7:00m P -10:00Pm Room 121 - 122 Room 113 - 114 P oster Reception I ORS Awards Gala Reception PTOA: Studies (authors present) and Dinner* in Preclinical Models Innovation Central/ Vista Ballroom 3:45m P -4:45Pm Spotlight Session Marquee Ballroom TION Diagnostic Imaging: Room 118 - 120 From Spine to Cartilage MA Spine Therapeutics Room 111 - 112 Room 121 – 122 INFOR

MONDAY, arch 30, 2015 L 6:30m a -7:45am 9:15A m-9:45Am 12:30m P -1:30Pm JOR Workshop A Room 117 Research Interest Group (RIG): Refreshment Break P oster Walking Tours Good and Bad Animal Models Innovation Central/ Innovation Central/ Professional Advancement

Room 106 - 107 Marquee Ballroom Marquee Ballroom Session: Rising to the Top: GENER Leadership Success New Investigator Networking in Academics Session: Position OUT Yourself for Room 121-122 7:00m a -9:45am 10:00m a -11:00AM a Successful Career: Setting P resent Your Science: G eneral Session: Shands Lecture, SOLDFoundational Early Career Goals Transforming Technical Talks with Presidential Address, 1st Vice Room 121-122 3:30m P -4:15Pm Melissa Marshall Presidential Address, and ORS Industry Connect Room 117 Business Meeting G eneral Session: Urist Lecture, Room 115 Room 118 - 120 OUT NIRA Awards, Video Outreach Competition Awards, Harris 8:00m a -9:00am SOLD Award, WLF Award, ORS/OREF 1:45m P -3:15Pm Collaborative Exchange Award, Mediators of Joint Repair 11:15m a -12:45Am ORS/POSNA Key Concepts of Distinguished Investigator Room 118-120 Aging & OA Musculoskeletal Infection Award, ORS Outstanding Room 118-120 Osteocytes and Mechanobiology Room 113 - 114 Achievement in Mentoring Award Room 111-112 Genetics: Bone Development, Room 118 - 120 Animal Welfare in Orthopaedic Bone Aging Shoulder and Elbow Arthroplasty Research: Focus on Refinement Room 111-112 Room 113-114 and Reduction 4:15m P -5:30Pm Shoulder and Elbow - Disease Room 116 Tendon/Ligaments - Mechanics Process P oster Reception II Room 121-122 The Realities of Commercializing Room 113-114 (authors present) Orthopaedic Technologies: Biglycan in Bone Healing Innovation Central/ Spine Disc Biology and Repair Business Strategies, Funding, Spotlight Session Marquee Ballroom Room 121-122 Partnerships, and Juggling Room 116 Academic & Corporate Roles Muscle/Tendon Biology and Room 111-112 Repair 7:30m P -10:00Pm 9:00m a -5:30Pm Room 116 ORS/MSTS The Osteoclast W omen’s Leadership Forum and Bone Diseases P oster and Exhibit Hall Open Reception Room 118 - 120 Innovation Central/ Vista Ballroom Marquee Ballroom

TUESDM AY, arch 31, 2015

6:00m a -3:30Pm 9:15m a -9:45Am 11:30m a -12:30Pm 2:00m P -2:30Pm P oster Hall Open (no exhibits) Refreshment Break P oster Walking Tours P osters Innovation Central/ Innovation Central/ Innovation Central/ Innovation Central/ Marquee Ballroom Marquee Ballroom Marquee Ballroom Marquee Ballroom

8:00m a -9:00Am 9:45m a -11:15Am 12:45m P -1:45Pm 2:30m P -3:30Pm Tendon/Ligament - T he Intervertebral Disc: From Ankle Arthritis, Arthroplasty, Knee - Mechanics and Modeling Collagen Structure – Function Development to Regeneration and Arthrodesis Room 111-112 Spotlight Session Room 121 - 122 Room 111-112 Bone Mechanics and Room 111-112 Functional Imaging of Title To Be Determined Finite Element Analysis Bone Tissue Engineering Articular Cartilage by MRI Late Breaking Session Room 113-114 Room 113-114 Room 113 - 114 Room 113-114 Knee Ligaments and Meniscus Biomolecular Approaches Hip Evo Devo: Adaptation of the Repair of Bone Fractures Room 116 to Bone Fragility Hip in Phylogeny and Ontogeny Spotlight Session Cartilage Mechanobiology Spotlight Session Room 116 Room 116 Room 118-120 Room 116 Acute Cartilage Injury: AO Chondro-Progenitors and Biomaterials for Cartilage Repair Cartilage Matrix Biology Foundation Collaborative Chondrogenesis Room 121-122 Spotlight Session Research Project Room 118-120 Room 118-120 Room 111 - 112 Tissue Engineering: Models of Spine Mechanics Bone Injury 159 Room 121-122 Room 121-122 daily meeting highlights F riday, March 27, 2015 7:00m a -6:00pm 6:00m P -8:00pm AAOS 2015 Annual Meeting Research Interest Group: Venetian/Sands EXPO Bone Regeneration Room 106 - 107 Saturday, March 28, 2015

8:00m a -10:30am 12:00m P -8:00Pm Cell Differentiation Fibrosis & ORS/The HIP Society - Biological Poster and Exhibit Hall Open Cancer Aspects of Modular Implant Research Interest Group: Growth Innovation Central/ Room 116 Tribocorrosion Factors New Horizon Workshop Marquee Ballroom OA & Cartilage Room 106 - 107 Room 113 - 114 12:00m P -1:00Pm Room 118 – 120 Research Interest Group: Trials, Tribulations and Stem Cells & Tissue Repair Mechanobiology Bone Disease Triumphs of Conducting Room 121 – 122 Room 115 Room 111 – 112 Prospective Clinical Research Research Interest Group: Knee Kinematics and Gait 2:00m P -6:00Pm Studies: The How and Why Room 116 Orthopaedic Evidence Room 113-114 ORS/OREF Basic Room 117 Hip Disease, Kinematics, FAI Science Course: Part I * Quantitative MR Imaging: Research Interest Group: Tendon Room 116 Room 117 Research Applications and Clinical Translation Room 121 - 122 2:30Pm-3:00Pm Advanced Articular Cartilage Room 118 - 120 Research Interest Group: Imaging Techniques Refreshment Break Professional Advancement Spine Research Community Spotlight Session Innovation Central/ Session-Career Advancement: Room 116 (concludes at 10am) Room 118 - 120 Marquee Ballroom Winning the Uphill Battle for ORS Advocacy Roundtable Intervertebral Disc: Research Funding Room 111 - 112 Degeneration, Room 121 - 122 Pain and Treatment 2:45m P -3:00Pm Spotlight Session I nnovation Theater Presentation: 11:00m a -12:00Pm Room 121 – 122 THINK Surgical 4:45m P -5:45Pm TCAT™ as a Research Tool New Investigator Networking W elcome Session – OUT Innovation Central/ Session: Strategic Lab and Time Guest Nation, Patient Story, 1:15m P -2:15Pm Marquee Ballroom SOLDManagement Presidential Guest Speaker Room 117 NIRA Presentations: Room 118 – 120 Mentor ConnecOUTt Bone Biology & Repair 3:00m P -4:30Pm Room 115 Room 111 – 112 SOLD Hot Topics in Regulatory 6:00m P -8:00Pm Joint Physiology & Mechanics Challenges within Orthopaedics P resident’s Welcome Reception Room 113 - 114 Room 111 - 112 Innovation Central/ Marquee Ballroom SUNDM AY, arch 29, 2015

8:00m a -11:15am 9:15m a -10:15Pm 11:15A m-12:30Pm 1:30m P -1:45Pm ORS/OREF Basic Science Course: Osteoblasts/Progenitor Cells Kappa Delta, OREF, CORR® I nnovation Theater Presentation: Part II* Room 111 - 112 ORS Award Paper Presentations AMTI Room 117 Room 118 - 120 Refining Simulation in a Total Hip Replacement Bio-fedelic Testing Environment Metal Wear Reactions 12:45m P -1:45Pm Innovation Central/ Room 113 – 114 8:00m a -9:00am P oster Walking Tours Marquee Ballroom Imaging and Bone Healing Innovation Central/ Biomaterials for Bone Repair Spotlight Session Marquee Ballroom Room 111-112 Room 116 New Investigator Networking 12:45m P -5:00Pm Knee - Mechanics Knee OA Repair Session: An Inside Look at C linical Research Forum- Room 113-114 Spotlight Session Research Funding OUT Opportunities The Basis for Clinical Decision Bone Necrosis Room 118-120 SOLDwith the National Institutes of Making in Orthopaedics Spotlight Session Health (NIH) Room 116 Tendon/Ligament - Room 116 Room 115 Repair and Tissue Engineering Pain Pathways and Therapies Room 121 – 122 ORS Translational Research in Experimental OA Symposium: Cartilage Repair: 2:00m P -3:30Pm Spotlight Session Is it Possible? ORS/OTA - Systemic Inflammation Room 118 - 120 10:30m a -11:00am Room 121-122 and Organ Dysfunction in Multiply Injured Patients Tendon/Ligament Cell Biology Refreshment Break New Horizon Workshop Room 121-122 Innovation Central/ Room 113 - 114 Marquee Ballroom 1:00m P -1:15Pm I nnovation Theater ORS/SOMOS - How an Integrated 9:00m a -6:00Pm Presentation: Orthosis and Rehabilitation National Disease Research Initiative has Improved Outcomes P oster and Exhibit Hall Open 10:45AM-11:00AM Interchange (NDRI) for Lower Extremity Limb Salvage Innovation Central/ I nnovation Theater Presentation: Project-driven Human Patients Marquee Ballroom Micro Photonics Biospecimen Service for Room 111 - 112 Advancements in Nano- Biomedical Research Computed Tomography for Improving the Translational Innovation Central/ Orthopedic Applications Success of Cell-Based Therapies Marquee Ballroom 160 Innovation Central/ Room 118 – 120 Marquee Ballroom