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Sociedad Española De Virología VIROLOGÍA Publicación Oficial de la Sociedad Española de Virología XI CONGRESO SOCIEDAD ESPAÑOLA DE VIROLOGÍA NACIONAL D VIROLOGÍA GRANADA 201 1 Volumen 14 Número 1/2011 EXTRAORDINARIO XI CONGRESO NACIONAL D VIROLOGÍA GRANADA 2011 COMITÉ EDITORIAL COMITÉ CIENTÍFICO Comité Organizador Junta Directiva de la SEV Jose María Navarro Tomas Pumarola Presidente: Presidente: Alfredo Berzal Diego Arroyo Alfredo Berzal Herranz Esteban Domingo Solans Enrique Moriones Raul Ortiz de Lejarazu Secretario: Vicepresidente: Mercedes Pérez Francisco Martín José María Navarro Marí Ricardo Flores Pedauyé Cecilio López Ramón Alemany Vocales: Secretario: Juan Antonio García Antonio Villaverde Jordi Gómez Castilla Antonio Talavera Díaz Purificación Fortes Jordi Gómez Carles Suñé Negre Vicesecretario: Jesús Navas Margarita del Val Mercedes Pérez Ruiz Fernando de Ory Manchón Ramón Soriguer Carles Suñé Javier Rodríguez Granger Tesorero: Juan Carlos Saiz José Antonio Darós Enrique Moriones Josep Quer Sivila Amelia Nieto Juan María Torres Isabel Mª Cuadrado Vocales: Eduardo Bejarano Rafael Fernandez Alfonso Ruiz Bravo Juan Carlos Alonso Navarro José María Casasnovas Xavi Bosch Juan Carlos Saiz Rafael Blasco Lozano José Maria Almendral Santiago Elena Alberto Bosch Navarro Vicente Pallás Susanna C. Manrubia Ana María Doménech Gómez Ana Angulo Jordi Reina Rafael Fernández Muñoz Joseph Quer Julián de la Torre Juan García Costa Luis Enjuanes David Navarro Esperanza Gómez-Lucía y Duato Francisco Sobrino Mª Ángeles Muñoz Fernández Ricardo Flores Amelia Nieto Martín Antonio Mas Pilar Pérez Breña Encarnación Martínez Fernando Rodríguez González Juana Díez Javier Romero Cano Carlos Briones Luis Valenciano Clavel Fernando García Nuria Verdaguer Mauricio García Fernando Rodríguez Juan Emilio Echevarría Albert Bosch Concepción Gimeno Gloria Trallero Mariano Cambra Virología. Publicación Oficial de la Sociedad Española de Virología Volumen 14 - Número 01/2011 - Extraordinario XI CONGRESO NACIONAL D VIROLOGÍA GRANADA 2011 ÍNDICE ÍNDICE COMITÉ EDITORIAL SESIÓN PLENARIA (V): Comité Organizador INTERACCIÓN VIRUS-HUESPED (II) Junta Directiva SEV Comité Científico SESIÓN PARALELA VII: RepLICACIÓN VÍRICA (II) ÍNDICE SESIÓN PARALELA VIII: CONFERENCIAS EVOLUCIÓN VIRAL Conferencia Inaugural Conferencia Extraordinaria SESIÓN PARALELA IX: Conferencia de Clausura MecANISMOS DE PATOGENIA Y PERSISTENCIA VÍRICA SESIÓN PLENARIA (I) SESIÓN PARALELA X: PATROCINADO POR FIPSE: RespUESTA INMUNE Y VACUNAS (II) ESTRATEGIAS MOLECULARES Y CELULARES EN LA LUCHA CONTRA EL SESIÓN PARALELA XI: HIV VIRUS EN TERAPIA Y CÁNCER SESIÓN PLENARIA (II): SESIÓN PARALELA XII: PEQUEÑOS RNAs, EXPRESIÓN Y SILENCIAMIENTO GÉNICO MORFOGÉNESIS Y ESTRUCTURA DEL VIRIÓN SESIÓN PLENARIA (III): SesiÓN PLenARIA (VI): INTERACCIÓN VIRUS-HUÉSPED (I) SESIÓN CONJUNTA CON LA SOCIEDAD ESPAÑOLA DE SESIÓN PARALELA I: MicROBIOLOGÍA (SEM): RepLICACIÓN VÍRICA (I) MeTAGENÓMICA AMBIENTAL Y CLÍNICA SESIÓN PARALELA II: POSTERS INTERACCIÓN VIRUS-HUÉSPED (III) INFORMACIÓN SEV SESIÓN PARALELA III: Próximo número Revista SEV EPIDEMIOLOGÍA Y CONTROL DE INFECCIONES VÍRICAS Máster en Virología SESIÓN PARALELA IV: RESPUESTA INMUNE Y VACUNAS (I) SESIÓN PARALELA V: SEÑALES VÍRICAS. DOMINIOS GENÓMICOS SESIÓN PARALELA VI: AcTUALIZACIÓN EN TÉCNICAS DE DIAGNÓSTICO VIROLÓGICO SESIÓN PLENARIA (IV): BROTES, EMERGENCIA Y SEGURIDAD VÍRICA Virología. Publicación Oficial de la Sociedad Española de Virología Volumen 14 - Número 01/2011 - Extraordinario XI CONGRESO NACIONAL D VIROLOGÍA GRANADA 2011 ÍNDICE ÍNDICE COMITÉ EDITORIAL SESIÓN PLENARIA (V): Comité Organizador INTERACCIÓN VIRUS-HUESPED (II) Junta Directiva SEV Comité Científico SESIÓN PARALELA VII: RepLICACIÓN VÍRICA (II) ÍNDICE SESIÓN PARALELA VIII: CONFERENCIAS EVOLUCIÓN VIRAL Conferencia Inaugural Conferencia Extraordinaria SESIÓN PARALELA IX: Conferencia de Clausura MecANISMOS DE PATOGENIA Y PERSISTENCIA VÍRICA SESIÓN PLENARIA (I) SESIÓN PARALELA X: PATROCINADO POR FIPSE: RespUESTA INMUNE Y VACUNAS (II) ESTRATEGIAS MOLECULARES Y CELULARES EN LA LUCHA CONTRA EL SESIÓN PARALELA XI: HIV VIRUS EN TERAPIA Y CÁNCER SESIÓN PLENARIA (II): SESIÓN PARALELA XII: PEQUEÑOS RNAs, EXPRESIÓN Y SILENCIAMIENTO GÉNICO MORFOGÉNESIS Y ESTRUCTURA DEL VIRIÓN SESIÓN PLENARIA (III): SesiÓN PLenARIA (VI): INTERACCIÓN VIRUS-HUÉSPED (I) SESIÓN CONJUNTA CON LA SOCIEDAD ESPAÑOLA DE SESIÓN PARALELA I: MicROBIOLOGÍA (SEM): RepLICACIÓN VÍRICA (I) MeTAGENÓMICA AMBIENTAL Y CLÍNICA SESIÓN PARALELA II: POSTERS INTERACCIÓN VIRUS-HUÉSPED (III) INFORMACIÓN SEV SESIÓN PARALELA III: Próximo número Revista SEV EPIDEMIOLOGÍA Y CONTROL DE INFECCIONES VÍRICAS Máster en Virología SESIÓN PARALELA IV: RESPUESTA INMUNE Y VACUNAS (I) SESIÓN PARALELA V: SEÑALES VÍRICAS. DOMINIOS GENÓMICOS SESIÓN PARALELA VI: AcTUALIZACIÓN EN TÉCNICAS DE DIAGNÓSTICO VIROLÓGICO SESIÓN PLENARIA (IV): BROTES, EMERGENCIA Y SEGURIDAD VÍRICA Virología. Publicación Oficial de la Sociedad Española de Virología Volumen 14 - Número 01/2011 - Extraordinario XI CONGRESO NACIONAL D VIROLOGÍA GRANADA 2011 CONFERENCIAS CONFERENCIA INAUGURAL por primera vea hace unos quince años, abrió las puertas al diseño de nuevas vacunas ate- El virus respiratorio sincitial nuadas bien definidas, algunas de las cuales 25 años después se encuentran en fases avanzadas de ensayos clínicos. Así mismo, el estudio de la entrada del Dr. José Antonio Melero virus en la célula y de los mecanismos de re- Centro Nacional de Microbiología, Instituto plicación y transcripción del genoma viral han de Salud Carlos III, Majadahonda, Madrid dado a la luz moléculas prometedoras que es- tán siendo desarrolladas en varios laboratorios, Hace aproximadamente 25 años decidimos entre ellos el nuestro. afrontar en nuestro laboratorio el desafío de trabajar con el virus respiratorio sincitial (VRS), Por último, uno de los aspectos más caracterís- uno de los patógenos virales más relevantes y ticos de la infección por el VRS es la respuesta del que desconocíamos gran parte de los as- inmune/inflamatoria, cuya modulación resulta pectos básicos de su ciclo infectivo. Desde en- imprescindible para evitar los efectos inmuno- tonces se ha avanzado sustancialmente en el patológicos adversos evidenciados en el pa- conocimiento de la biología molecular del VRS, sado. El estudio de la interacción virus-célula sin que por ello hayamos podido mejorar aún y de la respuesta del organismo a la infección significativamente la prevención o la terapia de por VRS también está aportando resultados las infecciones causadas por este virus. Un re- prometedores que, sin duda, terminarán con- ciente metanálisis a nivel mundial estimaba que tribuyendo a nuevas líneas de defensa frente las infecciones graves por RSV afectan a 20- al virus. 40 millones de niños menores de 5 años, con alrededor de 3-4 millones que requieren hospi- En definitiva, lo que pensábamos hace 25 años talización y un número de fallecidos de 60-170 sobre el VRS ha resultado bastante más com- mil/año. El 99% de estas muertes ocurren en plejo de lo, quizá ingenuamente, habíamos países en vías de desarrollo. A pesar de estas previsto. Pero la tarea a la que nos hemos de- cifras, todavía hoy no se dispone de ningún an- dicado estos años también nos ha aportado al- tiviral específico para el tratamiento de las in- gunas satisfacciones y sin duda hoy estamos fecciones por este virus, ni hay ninguna vacuna mejor posicionados para abordar los retos que para prevenirlas. El único producto comerciali- quedan para controlar más eficazmente una de zado es un anticuerpo monoclonal que usado las infecciones más graves y prevalentes que profilácticamente reduce en un 50% el número siguen afectando al ser humano. de hospitalizaciones por RSV en niños con alto riesgo de tener una enfermedad grave. Sin em- bargo, el elevadísimo coste de este tratamiento impide el uso generalizado del mismo. CONFERENCIA EXTRAORDINARIA Aun con estos precedentes, pensamos que la Flaviviral host factors: an investigación sigue siendo la única manera de RNA-centric view avanzar en el conocimiento del VRS y que tarde o temprano terminará aportando compuestos Katell Bidet (1), Brandt Levitt (2), Alex Ward químicos o biológicos que servirán para la pro- (1) Caroline LeSommer (2), Sharon Jamison filaxis o la terapia de las infecciones por VRS. (2), and Mariano A. Garcia-Blanco (1),(2) En este sentido, el rescate de virus a partir de Program in Emerging Infectious Diseases, copias de cDNA del genoma viral, conseguido Duke-NUS Graduate Medical School, Volumen 14 - Número 01/2011 - Extraordinario CONFERENCIAS Singapore (1), Center for RNA Biology, ha mantenido activo el interés de la comunidad Departments of Molecular Genetics científica tratando de descifrar las heterodoxas and Microbiology, and Medicine, Duke propiedades de este nuevo agente patógeno. University, Durham, NC USA (2) Recientemente la hipótesis ha sido demostra- Dengue and yellow fever viruses (DENV and da. La prueba definitiva ha requerido del desa- YFV) require an extensive number of factors, rrollo de la replicación de priones en un tubo yet only a limited number have been identified. de ensayo mediante la técnica de PMCA (del To discover these factors we have employed inglés: Protein Misfolding Cyclic Amplification), two complementary strategies: viral RNA-affinity un método que permite que el agente infeccio- chromatography/proteomics, and identification so pueda ser amplificado a expensas de una host proteins required for efficient viral propa- proteína que, de forma endógena, se encuen- gation using RNA interference-based functional tra fundamentalmente
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