Long-term retrospective observation reveals stabilities and variations of hantavirus infection in Hebei, China Shiyou Liu Hebei Center for Disease Control and Prevention https://orcid.org/0000-0002-7329-9731 Yamei Wei Hebei Center for Disease Control and Prevention Xu Han Hebei Center for Disease Control and Prevention Yanan Cai Hebei Center for Disease Control and Prevention Zhanying Han Hebei Center for Disease Control and Prevention Yanbo Zhang Hebei Center for Disease Control and Prevention Yonggang Xu Hebei Center for Disease Control and Prevention Shunxiang Qi Hebei Center for Disease Control and Prevention Qi Li (
[email protected] ) Research article Keywords: Hemorrhagic fever with renal syndrome, Hantavirus, Epidemiology Posted Date: May 28th, 2019 DOI: https://doi.org/10.21203/rs.2.9234/v2 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Version of Record: A version of this preprint was published on September 2nd, 2019. See the published version at https://doi.org/10.1186/s12879-019-4402-8. Page 1/15 Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic infectious disease caused by hantaviruses which circulate worldwide. So far, it was still considered as one of serious public health problems in China. The present study aimed to reveal the stabilities and variations of hantavirus infection in Hebei province located in North China through a long-term retrospective observation. Methods The epidemiological data of HFRS cases from all eleven cities of Hebei province since 1981 through 2016 were collected and descriptively analyzed. The rodent densities, species compositions and virus-carrying rates of different regions were collected from six separated rodent surveillance points which set up since 2007.