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PPIF / Cyclophilin F Antibody (Aa86-135) Rabbit Polyclonal Antibody Catalog # ALS15105

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PPIF / Cyclophilin F Antibody (Aa86-135) Rabbit Polyclonal Antibody Catalog # ALS15105 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 PPIF / Cyclophilin F Antibody (aa86-135) Rabbit Polyclonal Antibody Catalog # ALS15105 Specification PPIF / Cyclophilin F Antibody (aa86-135) - Product Information Application WB, IHC Primary Accession P30405 Reactivity Human, Mouse, Rat Host Rabbit Clonality Polyclonal Calculated MW 22kDa KDa PPIF / Cyclophilin F Antibody (aa86-135) - Additional Information Western blot of extracts from Gene ID 10105 HepG2/HeLa/293 cells, using PPIF Antibody. Other Names Peptidyl-prolyl cis-trans isomerase F, mitochondrial, PPIase F, 5.2.1.8, Cyclophilin D, CyP-D, CypD, Cyclophilin F, Mitochondrial cyclophilin, CyP-M, Rotamase F, PPIF, CYP3 Target/Specificity PPIF Antibody detects endogenous levels of total PPIF protein. Reconstitution & Storage Store at -20°C for up to one year. Precautions Anti-PPIF / Cyclophilin F antibody IHC of PPIF / Cyclophilin F Antibody (aa86-135) is for research use only and not for use in human adrenal. diagnostic or therapeutic procedures. PPIF / Cyclophilin F Antibody (aa86-135) - Background PPIF / Cyclophilin F Antibody (aa86-135) - Protein Information PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline Name PPIF imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability Synonyms CYP3 transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding Function site for inhibiting inorganic phosphate (Pi) and PPIase that catalyzes the cis-trans promotes the open probability of the mPTP isomerization of proline imidic peptide leading to apoptosis or necrosis; the bonds in oligopeptides and may therefore assist protein folding (PubMed:<a href="htt requirement of the PPIase activity for this Page 1/2 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 p://www.uniprot.org/citations/20676357" function is debated. In cooperation with target="_blank">20676357</a>). Involved mitochondrial TP53 is involved in activating in regulation of the mitochondrial oxidative stress- induced necrosis. Involved in permeability transition pore (mPTP) modulation of mitochondrial membrane (PubMed:<a href="http://www.uniprot.org/c F(1)F(0) ATP synthase activity and regulation itations/26387735" of mitochondrial matrix adenine nucleotide target="_blank">26387735</a>). It is levels. Has anti-apoptotic activity proposed that its association with the mPTP independently of mPTP and in cooperation with is masking a binding site for inhibiting BCL2 inhibits cytochrome c-dependent inorganic phosphate (Pi) and promotes the apoptosis. open probability of the mPTP leading to apoptosis or necrosis; the requirement of PPIF / Cyclophilin F Antibody (aa86-135) - the PPIase activity for this function is References debated (PubMed:<a href="http://www.unip rot.org/citations/26387735" Bergsma D.J.,et al.J. Biol. Chem. target="_blank">26387735</a>). In cooperation with mitochondrial p53/TP53 is 266:23204-23214(1991). involved in activating oxidative Ota T.,et al.Nat. Genet. 36:40-45(2004). stress-induced necrosis (PubMed:<a href=" Deloukas P.,et al.Nature 429:375-381(2004). http://www.uniprot.org/citations/22726440" Mural R.J.,et al.Submitted (JUL-2005) to the target="_blank">22726440</a>). Involved EMBL/GenBank/DDBJ databases. in modulation of mitochondrial membrane Johnson N.,et al.Eur. J. Biochem. F(1)F(0) ATP synthase activity and 263:353-359(1999). regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:<a href="http://www.uniprot.org/c itations/19228691" target="_blank">19228691</a>). Cellular Location Mitochondrion matrix Volume 50 µl PPIF / Cyclophilin F Antibody (aa86-135) - Protocols Provided below are standard protocols that you may find useful for product applications. • Western Blot • Blocking Peptides • Dot Blot • Immunohistochemistry • Immunofluorescence • Immunoprecipitation • Flow Cytomety • Cell Culture Page 2/2 Powered by TCPDF (www.tcpdf.org).
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