bioRxiv preprint doi: https://doi.org/10.1101/090860; this version posted June 29, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 5 New genes and functional innovation in mammals José Luis Villanueva-Cañas1,#, Jorge Ruiz-Orera1, M.Isabel Agea1, Maria Gallo2, David Andreu2, 1,2,3,* M.Mar Albà 10 1Evolutionary Genomics Group, Research Programme in Biomedical Informatics, Hospital del Mar Research Institute (IMIM), Barcelona, Spain; 2Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; 3Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. 15 Key words: de novo gene, species-specific gene, lineage-specific gene, evolutionary innovation, adaptive evolution, mammals Running title: New genes in mammals #Current address: Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Barcelona, Spain * Corresponding author:
[email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/090860; this version posted June 29, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. ABSTRACT The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions 5 they are selected for. To address these questions we have obtained a large collection of mammalian-specific gene families that lack homologues in other eukaryotic groups.